1,049 results on '"Cowman, Alan F."'
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2. Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3
3. Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein
4. PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum
5. Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1
6. Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.
7. RhopH2 and RhopH3 export enables assembly of the RhopH complex on P. falciparum-infected erythrocyte membranes
8. Flp/FRT-mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver-stage development.
9. Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity
10. Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity
11. Reticulocyte Binding Protein Homologue 5 is a target of balancing selection in the Plasmodium falciparum population of Papua New Guinea
12. Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein
13. 4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
14. Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine
15. Aryl amino acetamides prevent the development ofPlasmodium falciparumrings via inhibition of the lipid transfer protein PfSTART1
16. Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics
17. Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex
18. Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte
19. Signal-Mediated Export of Proteins from the Malaria Parasite to the Host Erythrocyte
20. Molecular Mechanism for Switching of P. falciparum Invasion Pathways into Human Erythrocytes
21. Targeting Malaria Virulence and Remodeling Proteins to the Host Erythrocyte
22. Chemo‐proteomics in antimalarial target identification and engagement
23. The Cytoplasmic Domain of the Plasmodium flaciparum Ligand EBA-175 Is Essential for Invasion but Not Protein Trafficking
24. Erythrocyte-Binding Antigen 175 Mediates Invasion in Plasmodium falciparum Utilizing Sialic Acid-Dependent and -Independent Pathways
25. Vaccine Development
26. Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum
27. Functional Analysis of Plasmodium falciparum Merozoite Antigens: Implications for Erythrocyte Invasion and Vaccine Development
28. Targeted Disruption of an Erythrocyte Binding Antigen in Plasmodium falciparum Is Associated with a Switch toward a Sialic Acid-Independent Pathway of Invasion
29. Clag9: A Cytoadherence Gene in Plasmodium falciparum Essential for Binding of Parasitized Erythrocytes to CD36
30. The Adhesion of Plasmodium falciparum-Infected Erythrocytes to Chondroitin Sulfate A Is Mediated by P. falciparum Erythrocyte Membrane Protein 1
31. Nuclear-Encoded Proteins Target to the Plastid in Toxoplasma gondii and Plasmodium falciparum
32. Cryo-EM structure of an essential Plasmodium vivax invasion complex
33. Mutations in Dihydropteroate Synthase are Responsible for Sulfone and Sulfonamide Resistance in Plasmodium falciparum
34. 7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex
35. Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4
36. Nanobodies against Pfs230 block Plasmodium falciparum transmission
37. RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting
38. Characterization of Promoters and Stable Transfection by Homologous and Nonhomologous Recombination in Plasmodium falciparum
39. Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V
40. Different Regions of Plasmodium falciparum Erythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy
41. A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4
42. Guided STED nanoscopy enables super-resolution imaging of blood stage malaria parasites
43. The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria
44. Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362
45. Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria
46. Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton
47. Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity
48. Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax
49. The Plasmodium falciparum Genome: A Blueprint for Erythrocyte Invasion
50. A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial
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