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593 results on '"Cox, N. J."'

1. Large Interstellar Polarisation Survey. LIPS I: FORS2 spectropolarimetry in the Southern Hemisphere

Author

Bagnulo, S., Cox, N. J. L., Cikota, A., Siebenmorgen, R., Voshchinnikov, N. V., Patat, F., Smith, K. T., Smoker, J., Taubenberger, S., Kaper, L., Cami, J., and collaboration, the LIPS

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Polarimetric studies of light transmitted through interstellar clouds may give constraints on the properties of the interstellar dust grains. Traditionally, broadband linear polarisation (BBLP) measurements have been considered an important diagnostic tool for the study of the interstellar dust, while comparatively less attention has been paid to spectropolarimetric measurements. However, spectropolarimetry may offer stronger constraints than BBLP, for example by revealing narrowband features, and by allowing us to distinguish the contribution of dust from the contribution of interstellar gas. Therefore, we have decided to carry out a Large Interstellar Polarisation Survey (LIPS) using spectropolarimetric facilities in both hemispheres. Here we present the results obtained in the Southern Hemisphere with the FORS2 instrument of the ESO Very Large Telescope. Our spectra cover the wavelength range 380--950\,nm at a spectral resolving power of about 880. We have produced a publicly available catalogue of 127 linear polarisation spectra of 101 targets. We also provide the Serkowski-curve parameters, as well as the wavelength gradient of the polarisation position angle for the interstellar polarisation along 76 different lines of sight. In agreement with previous literature, we found that the best-fit parameters of the Serkowski-curve are not independent of each other. However, the relationships that we obtained are not always consistent with what was found in previous studies., Comment: Accepted by A&A (replaced on 12 October 2017 simply to correct a Metadata error)

Published
2017
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8. Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics

Author

Partanen, J. J. (Juulia J.), Häppölä, P. (Paavo), Zhou, W. (Wei), Lehisto, A. A. (Arto A.), Ainola, M. (Mari), Sutinen, E. (Eva), Allen, R. J. (Richard J.), Stockwell, A. D. (Amy D.), Leavy, O. C. (Olivia C.), Oldham, J. M. (Justin M.), Guillen-Guio, B. (Beatriz), Cox, N. J. (Nancy J.), Hirbo, J. B. (Jibril B.), Schwartz, D. A. (David A.), Fingerlin, T. E. (Tasha E.), Flores, C. (Carlos), Noth, I. (Imre), Yaspan, B. L. (Brian L.), Jenkins, R. G. (R. Gisli), Wain, L. V. (Louise V.), Ripatti, S. (Samuli), Pirinen, M. (Matti), I. I. (International IPF Genetics Consortium), G. B. (Global Biobank Meta-Analysis Initiative (GBMI)), Laitinen, T. (Tarja), Kaarteenaho, R. (Riitta), Myllärniemi, M. (Marjukka), Daly, M. J. (Mark J.), Koskela, J. T. (Jukka T.), Partanen, J. J. (Juulia J.), Häppölä, P. (Paavo), Zhou, W. (Wei), Lehisto, A. A. (Arto A.), Ainola, M. (Mari), Sutinen, E. (Eva), Allen, R. J. (Richard J.), Stockwell, A. D. (Amy D.), Leavy, O. C. (Olivia C.), Oldham, J. M. (Justin M.), Guillen-Guio, B. (Beatriz), Cox, N. J. (Nancy J.), Hirbo, J. B. (Jibril B.), Schwartz, D. A. (David A.), Fingerlin, T. E. (Tasha E.), Flores, C. (Carlos), Noth, I. (Imre), Yaspan, B. L. (Brian L.), Jenkins, R. G. (R. Gisli), Wain, L. V. (Louise V.), Ripatti, S. (Samuli), Pirinen, M. (Matti), I. I. (International IPF Genetics Consortium), G. B. (Global Biobank Meta-Analysis Initiative (GBMI)), Laitinen, T. (Tarja), Kaarteenaho, R. (Riitta), Myllärniemi, M. (Marjukka), Daly, M. J. (Mark J.), and Koskela, J. T. (Jukka T.)

Abstract

Summary The research of rare and devastating orphan diseases, such as idiopathic pulmonary fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the prevalence of IPF is only approximately four times the incidence, limiting the recruitment of patients to trials and studies of the underlying biology. Global biobanking efforts can dramatically alter the future of IPF research. We describe a large-scale meta-analysis of IPF, with 8,492 patients and 1,355,819 population controls from 13 biobanks around the globe. Finally, we combine this meta-analysis with the largest available meta-analysis of IPF, reaching 11,160 patients and 1,364,410 population controls. We identify seven novel genome-wide significant loci, only one of which would have been identified if the analysis had been limited to European ancestry individuals. We observe notable pleiotropy across IPF susceptibility and severe COVID-19 infection and note an unexplained sex-heterogeneity effect at the strongest IPF locus MUC5B.

Published
2022

12. Daily Mean Sea Level Pressure Reconstructions for the European–North Atlantic Region for the Period 1850–2003

Author

Ansell, T. J., Jones, P. D., Allan, R. J., Lister, D., Parker, D. E., Brunet, M., Moberg, A., Jacobeit, J., Brohan, P., Rayner, N. A., Aguilar, E., Alexandersson, H., Barriendos, M., Brandsma, T., Cox, N. J., Della-Marta, P. M., Drebs, A., Founda, D., Gerstengarbe, F., Hickey, K., Jónsson, T., Luterbacher, J., Nordli, Ø., Oesterle, H., Petrakis, M., Philipp, A., Rodwell, M. J., Saladie, O., Sigro, J., Slonosky, V., Srnec, L., Swail, V., García-Suárez, A. M., Tuomenvirta, H., Wang, X., Wanner, H., Werner, P., Wheeler, D., and Xoplaki, E.

Published
2006

16. Rapid, climate-driven changes in outlet glaciers on the Pacific coast of East Antarctica

Author

Miles, B. W. J., Stokes, C. R., Vieli, A., and Cox, N. J.

Subjects
Glaciers -- Environmental aspects, Global temperature changes -- Environmental aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Multidecadal trends in the terminus position of outlet glaciers along the margin of the East Antarctic ice sheet reveal three epochal patterns of glacier retreat or advance consistent with a rapid and coherent response to air temperature and sea-ice trends. East Antarctic ice sensitive to climate variation It is widely known that glaciers in West Antarctica and Greenland have been discharging ice into the oceans in response to warming in recent years, and that sea levels have risen as a result. By contrast, we hear little about the much larger East Antarctic ice sheet, which has been viewed as being less vulnerable to climate change owing to its location in an extremely cold climate. Chris Stokes and colleagues have used satellite imagery to map a large sample of glaciers along the Pacific coast of East Antarctica and show that in fact, they are responding to decadal climate variability. In concert with climate, glaciers retreated in the 1970s and 1980s, advanced in the 1990s, and approximately split between advance and retreat since the 2000s. The authors conclude that parts of the world's largest ice sheet may be more responsive to external forcing than previously recognized. Observations of ocean-terminating outlet glaciers in Greenland and West Antarctica.sup.1,2,3,4,5,6 indicate that their contribution to sea level is accelerating as a result of increased velocity, thinning and retreat.sup.7,8,9,10,11. Thinning has also been reported along the margin of the much larger East Antarctic ice sheet.sup.1, but whether glaciers are advancing or retreating there is largely unknown, and there has been no attempt to place such changes in the context of localized mass loss.sup.7,9 or climatic or oceanic forcing. Here we present multidecadal trends in the terminus position of 175 ocean-terminating outlet glaciers along 5,400 kilometres of the margin of the East Antarctic ice sheet, and reveal widespread and synchronous changes. Despite large fluctuations between glaciers--linked to their size--three epochal patterns emerged: 63 per cent of glaciers retreated from 1974 to 1990, 72 per cent advanced from 1990 to 2000, and 58 per cent advanced from 2000 to 2010. These trends were most pronounced along the warmer western South Pacific coast, whereas glaciers along the cooler Ross Sea coast experienced no significant changes. We find that glacier change along the Pacific coast is consistent with a rapid and coherent response to air temperature and sea-ice trends, linked through the dominant mode of atmospheric variability (the Southern Annular Mode). We conclude that parts of the world's largest ice sheet may be more vulnerable to external forcing than recognized previously., Author(s): B. W. J. Miles [sup.1] , C. R. Stokes [sup.1] , A. Vieli [sup.1] [sup.2] , N. J. Cox [sup.1] Author Affiliations: (1) Department of Geography, Durham University, Science [...]

Published
2013
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17. Genome-wide association study of Tourette's syndrome

Author

Scharf, J M, Yu, D, Mathews, C A, Neale, B M, Stewart, S E, Fagerness, J A, Evans, P, Gamazon, E, Edlund, C K, Service, S K, Tikhomirov, A, Osiecki, L, Illmann, C, Pluzhnikov, A, Konkashbaev, A, Davis, L K, Han, B, Crane, J, Moorjani, P, Crenshaw, A T, Parkin, M A, Reus, V I, Lowe, T L, Rangel-Lugo, M, Chouinard, S, Dion, Y, Girard, S, Cath, D C, Smit, J H, King, R A, Fernandez, T V, Leckman, J F, Kidd, K K, Kidd, J R, Pakstis, A J, State, M W, Herrera, L D, Romero, R, Fournier, E, Sandor, P, Barr, C L, Phan, N, Gross-Tsur, V, Benarroch, F, Pollak, Y, Budman, C L, Bruun, R D, Erenberg, G, Naarden, A L, Lee, P C, Weiss, N, Kremeyer, B, Berrío, G B, Campbell, D D, Cardona Silgado, J C, Ochoa, W C, Mesa Restrepo, S C, Muller, H, Valencia Duarte, A V, Lyon, G J, Leppert, M, Morgan, J, Weiss, R, Grados, M A, Anderson, K, Davarya, S, Singer, H, Walkup, J, Jankovic, J, Tischfield, J A, Heiman, G A, Gilbert, D L, Hoekstra, P J, Robertson, M M, Kurlan, R, Liu, C, Gibbs, J R, Singleton, A, Hardy, J, Strengman, E, Ophoff, R A, Wagner, M, Moessner, R, Mirel, D B, Posthuma, D, Sabatti, C, Eskin, E, Conti, D V, Knowles, J A, Ruiz-Linares, A, Rouleau, G A, Purcell, S, Heutink, P, Oostra, B A, McMahon, W M, Freimer, N B, Cox, N J, and Pauls, D L

Published
2013
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18. Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants

Author

Gamazon, E R, Badner, J A, Cheng, L, Zhang, C, Zhang, D, Cox, N J, Gershon, E S, Kelsoe, J R, Greenwood, T A, Nievergelt, C M, Chen, C, McKinney, R, Shilling, P D, Schork, N J, Smith, E N, Bloss, C S, Nurnberger, J I, Edenberg, H J, Foroud, T, Koller, D L, Scheftner, W A, Coryell, W, Rice, J, Lawson, W B, Nwulia, E A, Hipolito, M, Byerley, W, McMahon, F J, Schulze, T G, Berrettini, W H, Potash, J B, Zandi, P P, Mahon, P B, McInnis, M G, Zöllner, S, Zhang, P, Craig, D W, Szelinger, S, Barrett, T B, and Liu, C

Published
2013
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25. Guidelines for investigating causality of sequence variants in human disease

Author

MacArthur, D. G., Manolio, T. A., Dimmock, D. P., Rehm, H. L., Shendure, J., Abecasis, G. R., Adams, D. R., Altman, R. B., Antonarakis, S. E., Ashley, E. A., Barrett, J. C., Biesecker, L. G., Conrad, D. F., Cooper, G. M., Cox, N. J., Daly, M. J., Gerstein, M. B., Goldstein, D. B., Hirschhorn, J. N., Leal, S. M., Pennacchio, L. A., Stamatoyannopoulos, J. A., Sunyaev, S. R., Valle, D., Voight, B. F., Winckler, W., and Gunter, C.

Published
2014
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47. Fan-Surface Evidence for Debris-Flow Avulsion Controls and Probabilities, Saline Valley, California

Author

de Haas, T., Densmore, A. L., den Hond, T., Cox, N. J., Landdegradatie en aardobservatie, and Landscape functioning, Geocomputation and Hydrology

Subjects
Atmospheric Science, Ecology, Palaeontology, Soil Science, Forestry, Aquatic Science, Oceanography, alluvial fan, Mojave Desert, Geophysics, Geochemistry and Petrology, Space and Planetary Science, debris flow, Earth and Planetary Sciences (miscellaneous), avulsion, Water Science and Technology, Earth-Surface Processes
Abstract

Debris-flow fans form by shifts of the active channel, termed avulsions. Field and experimental evidence suggest that debris-flow avulsions may be induced by depositional lobes that locally plug a channel or superelevation of the channel bed above the surrounding fan surface, by analogy to fluvial fans. To understand debris-flow avulsion processes, we differentiate between these controls by quantifying the spatial distribution of debris-flow lobe and channel dimensions, along with channel-bed superelevation, on nine debris-flow fans in Saline Valley, California, USA. Channel beds are generally superelevated by 2–5 channel depths above the fan surface, and locally by more than 7 channel depths, thereby substantially exceeding superelevation on fluvial fans. Depositional-lobe thickness and channel depth decrease with distance from the fan apex, although both are highly variable across the fans. Median channel depths roughly correspond to the 50th–75th percentiles of lobe thicknesses, while minimum channel depths roughly correspond to the 10th–25th percentiles. In contrast, the thicknesses of lobes that have triggered avulsions roughly equal local channel depths and are on average twice as thick as the local median lobe thickness. The spatial correspondence between avulsion locations and thick lobe deposits, and the lack of correlation with channel-bed superelevation, leads us to infer that avulsions on these fans are mostly caused by thick lobes forming channel plugs. Although results may vary with climatic and tectonic setting, our findings indicate that avulsion hazard assessment on populated fans should include mapping and monitoring of channel depths relative to typical deposit thicknesses on a given fan.

Published
2019

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