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569 results on '"Cram, D."'

1. Do honey badgers and greater honeyguide birds cooperate to access bees' nests? Ecological evidence and honey‐hunter accounts

Author

van der Wal, J. E. M., primary, Afan, A. I., additional, Anyawire, M., additional, Begg, C. M., additional, Begg, K. S., additional, Dabo, G. A., additional, Gedi, I. I., additional, Harris, J. A., additional, Isack, H. A., additional, Ibrahim, J. I., additional, Jamie, G. A., additional, Kamboe, W.‐B. W., additional, Kilawi, A. O., additional, Kingston, A., additional, Laltaika, E. A., additional, Lloyd‐Jones, D. J., additional, M'manga, G. M., additional, Muhammad, N. Z., additional, Ngcamphalala, C. A., additional, Nhlabatsi, S. O., additional, Oleleteyo, T. T., additional, Sanda, M., additional, Tsamkxao, L., additional, Wood, B. M., additional, Spottiswoode, C. N., additional, and Cram, D. L., additional

Published
2023
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16. Noninvasive prenatal diagnosis for pregnancies at risk for β-thalassaemia: a retrospective study.

Author

Lv, W, Linpeng, S, Li, Z, Liang, D, Jia, Z, Meng, D, Cram, DS, Zhu, H, Teng, Y, Yin, A, Wu, L, and Cram, D S

Subjects
PRENATAL diagnosis, NONINVASIVE diagnostic tests, INVASIVE diagnosis, SINGLE molecules, PREGNANCY tests, CELL-free DNA, DIAGNOSIS of fetal diseases, PILOT projects, HEMOGLOBINS, MOLECULAR diagnosis, RETROSPECTIVE studies, FETAL diseases, GENOTYPES, RESEARCH funding, BETA-Thalassemia
Abstract

Objective: To evaluate the clinical feasibility of noninvasive prenatal diagnosis (NIPD) for β-thalassaemia using circulating single molecule amplification and re-sequencing technology (cSMART).Design: Through carrier screening, 102 pregnant Chinese couples carrying pathogenic HBB gene variants were recruited to the study. Pregnancies were managed using traditional invasive prenatal diagnosis (IPD). Retrospectively, we evaluated the archived pregnancy plasma DNA by NIPD to evaluate the performance of our cSMART assay for fetal genotyping.Setting: Chinese prenatal diagnostic centres specialising in thalassaemia testing.Population: Chinese carrier couples at high genetic risk for β-thalassaemia.Methods: Fetal cell sampling was performed by amniocentesis and HBB genotypes were determined by reverse dot blot. NIPD was performed by a newly designed HBB cSMART assay and fetal genotypes were called by measuring the allelic ratios in the maternal cell-free DNA.Main Outcome Measures: Concordance of HBB fetal genotyping between IPD and NIPD and the sensitivity and specificity of NIPD.Results: Invasive prenatal diagnosis identified 29 affected homozygotes or compound heterozygotes, 54 heterozygotes and 19 normal homozygotes. Compared with IPD results, 99 of 102 fetuses (97%) were correctly genotyped by our NIPD assay. Two of three discordant samples were false positives and the other sample involved an incorrect call of a heterozygote carrier as a homozygote normal. Overall, the sensitivity and specificity of our NIPD assay was 100% (95% CI 88.06-100.00%) and 97.26% (95% CI 90.45-99.67%), respectively.Conclusions: This study demonstrates that our cSMART-based NIPD assay for β-thalassaemia has potential clinical utility as an alternative to IPD for pregnant HBB carrier couples.Tweetable Abstract: A new noninvasive test for pregnancies at risk for β-thalassaemia. [ABSTRACT FROM AUTHOR]

Published
2021
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17. John Wallis. Teaching Language to a Boy Born Deaf: the Popham Notebook and Associated Texts : edited and introduced

Author

Cram, D., Maat, J., Logic and Language (ILLC, FNWI/FGw), and ILLC (FGw)

Abstract

This book presents an edition of a previously unpublished notebook used by the seventeenth-century polymath John Wallis to teach language to the 'deaf mute' Alexander Popham. Under the terms of the law Popham would not have been able to inherit his family title and property if he had remained unable to speak. This is one of the most famous cases in the history of deaf education. The notebook, which has recently come to light in the Popham family mansion, provides fascinating insights into the details of the instruction. It is a rare example of a manual tailor-made for the instruction of a known individual and its author is one of the foremost scientists of the period. If it had not been lost the work would have been a key document in the dispute between John Wallis and William Holder, both distinguished fellows of the Royal Society, on whose method had been successful in teaching Popham to speak. The Popham Notebook provides essential evidence towards the resolution of a debate that has been widely discussed ever since. David Cram and Jaap Maat place the work in its personal, social, and scientific contexts. They include a range of additional contemporary texts and provide a clear text with helpful annotations. The edition provides the means for a thorough reassessment of the work's contemporary value. Their introduction also includes a discussion of the theoretical issues underpinning the teaching of language to the deaf.

Published
2017

18. Noninvasive fetal genotyping in pregnancies at risk for PKU using a comprehensive quantitative cSMART assay for PAH gene mutations: a clinical feasibility study.

Author

Lv, W, Li, Z, Wei, X, Zhu, H, Teng, Y, Zhou, M, Gong, Y, Cram, DS, Liang, D, Han, L, Wu, L, and Cram, D S

Subjects
HIGH-risk pregnancy, INVASIVE diagnosis, SINGLE molecules, PRENATAL diagnosis, FEASIBILITY studies, COMPARATIVE studies, DNA, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PHENYLKETONURIA, PREGNANCY complications, SECOND trimester of pregnancy, RESEARCH, RESEARCH funding, EVALUATION research, SEQUENCE analysis, GENOTYPES
Abstract

Objective: To assess the diagnostic performance of a novel circulating single molecule amplification and re-sequencing technology (cSMART) method for noninvasive prenatal testing (NIPT) of Phenylketonuria (PKU).Design: Blinded NIPT analysis of pregnancies at high risk for PKU.Setting: Shanghai Xinhua Hospital and Hunan Jiahui Genetics Hospital, China.Population: Couples (n = 33) with a child diagnosed with PKU.Methods: Trio testing for pathogenic PAH mutations was performed by Sanger sequencing. In second pregnancies, invasive prenatal diagnosis (IPD) was used to determine fetal genotypes. NIPT was performed using a PAH gene-specific cSMART assay. Based on the plasma DNA mutation ratio relative to the fetal DNA fraction, fetal genotypes were assigned using a maximum-likelihood algorithm.Main Outcome Measures: Concordance of fetal genotyping results between IPD and NIPT, and the sensitivity and specificity of the NIPT assay.Results: Compared with gold standard IPD results, 32 of 33 fetuses (96.97%) were accurately genotyped by NIPT. The sensitivity and specificity of the NIPT assay was 100.00% (95% CI 59.04-100.00%) and 96.15% (95% CI 80.36-99.90%), respectively.Conclusions: The novel cSMART assay demonstrated high accuracy for correctly calling fetal genotypes. We propose that this test has useful clinical utility for the rapid screening of high-risk and low-risk pregnancies with a known history of PKU on one or both sides of the family.Tweetable Abstract: NIPT of couples at high risk for PKU using a full-coverage cSMART PAH gene test. [ABSTRACT FROM AUTHOR]

Published
2019
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32. Do loanwords have sex?

Author

Awedyk, W., Fisiak, J., Hamans, C., Smelik, B., Hofman, R., Cram, D., and Generative linguistics

Published
2005

45. Safety of omacetaxine mepesuccinate (OM) subcutaneous (SQ) injection for the treatment of chronic myeloid leukemia (CML) patients (pts) resistant or intolerant to tyrosine kinase inhibitors (TKIs): Analysis of two phase II studies.

Author

Lipton, J. H., primary, Wetzler, M., additional, Nicolini, F., additional, Baccarani, M., additional, Baer, M. R., additional, Masszi, T., additional, Cram, D., additional, Benichou, A., additional, Nanda, N., additional, and Cortes, J. E., additional

Published
2010
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