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Your search keyword '"Crast LB Jr"' showing total 4 results
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4 results on '"Crast LB Jr"'

1. 3-Acylthiomethyl cephalosporins.

Author

Essery JM, Corbin U, Sprancmanis V, Crast LB Jr, Graham RG, Misco PF Jr, Willner D, McGregor DN, and Cheney LC

Subjects
Animals, Bacteria drug effects, Cephalexin pharmacology, Cephalosporins blood, Cephalosporins pharmacology, Chemical Phenomena, Chemistry, Mice, Microbial Sensitivity Tests, Sulfhydryl Compounds chemical synthesis, Time Factors, Cephalosporins chemical synthesis
Published
1974
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2. Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide.

Author

Gottstein WJ, Crast LB Jr, Graham RG, Haynes UJ, and McGregor DN

Subjects
Amoxicillin pharmacology, Animals, Chemical Phenomena, Chemistry, Clavulanic Acid, Escherichia coli Infections drug therapy, Mice, Mice, Inbred ICR, Penicillanic Acid pharmacology, Staphylococcal Infections drug therapy, Staphylococcus aureus drug effects, beta-Lactams pharmacology, Penicillanic Acid chemical synthesis, beta-Lactamase Inhibitors
Abstract

Potassium 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylate 1,1-dioxide (BL-P2013) and its pivaloyloxymethyl ester were prepared by the conversion of 6-aminopenicillanic acid to p-nitrobenzyl 6 alpha-bromo-2,2-dimethylpenam-3 alpha-carboxylate 1-oxide, which was rearranged with benzoyl chloride and quinoline to p-nitrobenzyl 6 alpha-bromo-2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylate in 65% yield. Oxidation and catalytic hydrogenation afforded BL-P2013, which was found to be a potent inhibitor of various bacterial beta-lactamases and has been found to protect amoxicillin from beta-lactamases in both in vitro and in vivo systems.

Published
1981
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3. Synthesis and in vitro activity of new semi-synthetic coumermycin analogs: chemical modification at the C-3 amide.

Author

Ueda Y, Chuang JM, Crast LB Jr, and Partyka RA

Subjects
Aminocoumarins, Anti-Bacterial Agents pharmacology, Chemical Phenomena, Chemistry, Coumarins chemical synthesis, Coumarins pharmacology, Gram-Positive Bacteria drug effects, Microbial Sensitivity Tests, Structure-Activity Relationship, Anti-Bacterial Agents chemical synthesis
Abstract

Several new semi-synthetic coumermycin analogs, which carry a polar substituent at the C-3 amide moiety have been prepared. In vitro antibacterial activity of these new analogs against Gram-positive organisms, particularly methicillin-resistant strains of Staphylococci species has been described.

Published
1989
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4. Synthesis of cephapirin and related cephalosporins from 7-(alpha-bromoacetamido)cephalosporanic acid.

Author

Crast LB Jr, Graham RG, and Cheney LC

Subjects
Acetamides pharmacology, Cephalosporins pharmacology, Escherichia coli drug effects, Klebsiella pneumoniae drug effects, Microbial Sensitivity Tests, Pyridines chemical synthesis, Pyridines pharmacology, Salmonella enteritidis drug effects, Staphylococcus drug effects, Streptococcus pneumoniae drug effects, Streptococcus pyogenes drug effects, Structure-Activity Relationship, Sulfides chemical synthesis, Sulfides pharmacology, Acetamides chemical synthesis, Cephalosporins chemical synthesis
Published
1973
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