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2 results on '"Crescencia López"'

1. Serological based monitoring of a cohort of patients with chronic Chagas disease treated with benznidazole in a highly endemic area of northern Argentina

Author

Leticia L Niborski, Vanina Grippo, Sonia O Lafón, Gabriela Levitus, Facundo García-Bournissen, Juan C Ramirez, Juan M Burgos, Margarita Bisio, Natalia A Juiz, Vilma Ayala, María Coppede, Verónica Herrera, Crescencia López, Ana Contreras, Karina A Gómez, Juan C Elean, Hugo D Mujica, Alejandro G Schijman, Mariano J Levin, and Silvia A Longhi

Subjects
Trypanosoma cruzi, chronic Chagas disease, benznidazole treatment, serological follow-up, adverse effects, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, was conducted from endemic areas of northern Argentina. Follow-up was possible in 107 out of them and blood samples were taken for serology and PCR assays before and 2, 3, 6, 12, 24 and 36 months after treatment initiation. Reactivity against Trypanosoma cruzi lysate and recombinant antigens was measured by ELISA. The rate of decrease of antibody titers showed nonlinear kinetics with an abrupt drop within the first three months after initiation of treatment for all studied antigens, followed by a plateau displaying a low decay until the end of follow-up. At this point, anti-B13, anti-1F8 and anti-JL7 titers were relatively close to the cut-off line, while anti-T. cruzi antibodies still remained positive. At baseline, 60.8% (45/74) of analysed patients tested positive for parasite DNA by PCR and during the follow-up period in 34 out of 45 positive samples (75.5%) could not be detected T. cruzi DNA. Our results suggest that these antigens might be useful as early markers for monitoring antiparasitic treatment in chronic Chagas disease.

Published
2016
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2. Serological based monitoring of a cohort of patients with chronic Chagas disease treated with benznidazole in a highly endemic area of northern Argentina

Author

Juan M. Burgos, Vilma Ayala, María Coppede, Natalia Anahí Juiz, Crescencia López, Alejandro G. Schijman, Mariano J. Levin, Margarita Bisio, Vanina Grippo, Hugo D Mujica, Leticia L. Niborski, Silvia Andrea Longhi, Facundo Garcia-Bournissen, Karina A. Gómez, Juan Carlos Ramirez, G Levitus, Juan C Elean, Sonia Lafon, Ana Contreras, and Verónica Herrera

Subjects
0301 basic medicine, Male, Time Factors, lcsh:QR1-502, Ciencias de la Salud, Antibodies, Protozoan, lcsh:Microbiology, Serology, Cohort Studies, 0302 clinical medicine, BENZNIDAZOLE TREATMENT, Parasitología, Prospective Studies, biology, Antibody titer, Articles, Middle Aged, Trypanocidal Agents, Benznidazole, Nitroimidazoles, Female, purl.org/becyt/ford/3 [https], Antibody, medicine.drug, Microbiology (medical), Chagas disease, Adult, serological follow-up, CIENCIAS MÉDICAS Y DE LA SALUD, lcsh:Arctic medicine. Tropical medicine, CHRONIC CHAGAS DISEASE, lcsh:RC955-962, Trypanosoma cruzi, 030231 tropical medicine, 030106 microbiology, Argentina, Antigens, Protozoan, Enzyme-Linked Immunosorbent Assay, 03 medical and health sciences, Young Adult, purl.org/becyt/ford/3.3 [https], Antigen, parasitic diseases, medicine, Humans, Chagas Disease, Seroconversion, SEROLOGICAL FOLLOW-UP, TRYPANOSOMA CRUZI, medicine.disease, biology.organism_classification, Virology, ADVERSE EFFECTS, Immunology, Chronic Disease, biology.protein, adverse effects, chronic Chagas disease, benznidazole treatment, Follow-Up Studies
Abstract

This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, was conducted from endemic areas of northern Argentina. Follow-up was possible in 107 out of them and blood samples were taken for serology and PCR assays before and 2, 3, 6, 12, 24 and 36 months after treatment initiation. Reactivity against Trypanosoma cruzi lysate and recombinant antigens was measured by ELISA. The rate of decrease of antibody titers showed nonlinear kinetics with an abrupt drop within the first three months after initiation of treatment for all studied antigens, followed by a plateau displaying a low decay until the end of follow-up. At this point, anti-B13, anti-1F8 and anti-JL7 titers were relatively close to the cut-off line, while anti-T. cruzi antibodies still remained positive. At baseline, 60.8% (45/74) of analysed patients tested positive for parasite DNA by PCR and during the follow-up period in 34 out of 45 positive samples (75.5%) could not be detected T. cruzi DNA. Our results suggest that these antigens might be useful as early markers for monitoring antiparasitic treatment in chronic Chagas disease. Fil: Niborski, Leticia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Grippo, Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Lafon, Sonia Olga. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Levitus, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: García Bournissen, Facundo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ramirez Gomez, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Burgos, Juan Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Bisio, Margarita María Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Juiz, Natalia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Ayala, Vilma. Centro Asistencial Cáritas Diocesana; Argentina Fil: Coppede, María. Centro Asistencial Cáritas Diocesana; Argentina Fil: Herrera, Verónica. Centro Asistencial Cáritas Diocesana; Argentina Fil: López, Crescencia. Centro Asistencial Cáritas Diocesana; Argentina Fil: Contreras, Ana. Centro Asistencial Cáritas Diocesana; Argentina Fil: Gomez, Karina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Elean, Juan C.. Centro Asistencial Cáritas Diocesana; Argentina Fil: Mujica, Hugo D.. Centro Asistencial Cáritas Diocesana; Argentina. Hospital Zonal de Añatuya; Argentina Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Levin, Mariano Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Longhi, Silvia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina

Published
2016

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