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1,008 results on '"Crescenzi M."'

2. Insulin Stimulates IL-23 Expression in Human Adipocytes: A Possible Explanation for the Higher Prevalence of Psoriasis in Obesity

Author

Di Vincenzo A, Granzotto M, Crescenzi M, Costa C, Piaserico S, Vindigni V, Vettor R, and Rossato M

Subjects
adipocyte, human, il-23, insulin, obesity, psoriasis, Specialties of internal medicine, RC581-951
Abstract

Angelo Di Vincenzo,1 Marnie Granzotto,1 Marika Crescenzi,1 Camilla Costa,1 Stefano Piaserico,2 Vincenzo Vindigni,3 Roberto Vettor,1 Marco Rossato1 1Department of Medicine – DIMED, Clinica Medica 3, University - Hospital of Padova, Padova, Italy; 2Department of Medicine - DIMED, Section of Dermatology, University - Hospital of Padova, Padova, Italy; 3Department of Neurosciences, Clinic of Plastic Reconstructive and Aesthetic Surgery, University – Hospital of Padova, Padova, ItalyCorrespondence: Marco Rossato, Department of Medicine – DIMED, Clinica Medica 3, University Hospital of Padova, Via Giustiniani 2, Padova, 35128, Italy, Tel +39 49 8218746, Fax +39 49 8213332, Email marco.rossato@unipd.itPurpose: Psoriasis is a chronic systemic inflammatory disease involving the production of many pro-inflammatory cytokines derived from immune cells and interacting with different tissues leading to the typical skin lesions. Psoriasis shows a higher prevalence and a worse progression in obese than in lean subjects. The IL-23/IL-17 immune axis has a pivotal role in the pathogenesis of psoriasis and anti-IL-23 monoclonal antibodies are highly effective in its treatment. Since obesity in frequently associated with elevated insulin plasma levels, we have investigated the ability of in vitro differentiated human adipocytes to produce IL-23 at basal conditions and after insulin stimulation.Material and Methods: In vitro differentiated human adipocytes were incubated in the absence and presence of different insulin concentrations and the expression of IL-23 was analyzed by real-time PCR and Western blotting.Results: The results of this study show that in vitro differentiated human adipocytes spontaneously express IL-23 mRNA and protein being stimulated by insulin in a dose-dependent manner. The stimulatory effects of insulin on IL-23 expression were specific since it did not stimulate the expression of other well-known cytokines involved in psoriasis pathogenesis such as Il-22 nor LL-37. Furthermore, lipopolysaccharide did not stimulate IL-23 expression in human adipocytes, thus highlightening the specific effects of insulin in the stimulation of IL-23 expression in human adipocytes.Conclusion: Here we show that human adipocytes spontaneously express IL-23 and that insulin stimulates IL-23 production by these cells in a specific manner as other stimuli, known to be involved in psoriasis pathophysiology, are ineffective. These observations could explain the association between psoriasis and obesity, a condition frequently characterized by a state of insulin hypersecretion.Keywords: adipocyte, human, IL-23, insulin, obesity, psoriasis

Published
2023

6. Electronic correlations in graphite and carbon nanotubes from Auger spectroscopy

Author

Perfetto, E., Cini, M., Ugenti, S., Castrucci, P., Scarselli, M., De Crescenzi, M., Rosei, F., and Khakani, M. A. El

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We have determined the screened on-site Coulomb repulsion in graphite and single wall carbon nanotubes by measuring their Auger spectra and performing a new theoretical analysis based on an extended Cini-Sawatzky approach where only one fit parameter is employed. The experimental lineshape is very well reproduced by the theory and this allows to determine the value of the screened on-site repulsion between $2p$ states, which is found to be 2.1 eV in graphite and 4.6 eV in nanotubes. The latter is robust by varying the nanotube radius from 1 to 2 nm., Comment: 5 pages, 3 figures, to appear in Phys. Rev. B

Published
2007
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8. Light induced tunnel effect in CNT-Si photodiode

Author

Aramo, C., Ambrosio, M., Bonavolontà, C., Boscardin, M., Castrucci, P., Crivellari, M., De Crescenzi, M., de Lisio, C., Fiandrini, E., Grossi, V., Maddalena, P., Passacantando, M., Santucci, S., Scarselli, M., Valentini, A., and Valentino, M.

Published
2016
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23. High graphene permeability for silicon atoms during deposition at room temperature: the role of defects

Author

Ronci, F., Colonna, S., Flammini, R., De Crescenzi, M., Scarselli, M., Salvato, M., Berbezier, I., Jardali, F., Lechner, C., Pochet, P., VACH, HOLGER, Castrucci, P., Istituto di Struttura della Materia (CNR-ISM), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Dipartimento di Fisica [Roma Tor Vergata], Università degli Studi di Roma Tor Vergata [Roma], Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique des interfaces et des couches minces [Palaiseau] (LPICM), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Grenoble Alpes (UGA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Consiglio Nazionale delle Ricerche [Roma] (CNR), and Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
Condensed Matter::Materials Science, ab initio molecular dynamics, Physics::Atomic and Molecular Clusters, Silicene, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Graphene, Scanning tunneling microscopy, Graphene intercalation, 2D Si clusters
Abstract

International audience; Graphene (Gr) is known to be an excellent barrier preventing atoms and molecules to diffuse through it. This is due to the carbon atom arrangement in a two-dimensional (2D) honeycomb structure with a very small lattice parameter thus forming an electron cloud that prevents atoms and molecules crossing. Nonetheless at high temperature of annealing, intercalation of atoms through graphene occurs, opening the path for formation of vertical heterojunctions formed of two-dimensional layers. In this paper, we report on the ability of silicon atoms to penetrate the graphene network, fully epitaxially grown on a Ni(111) surface, even at room temperature. Our scanning tunneling microscopy (STM) shows that defects like vacancies and dislocations of the graphene lattice favor the Si intercalation below the Gr layer forming two-dimensional, flat and disordered islands. Ab-initio molecular dynamics calculations confirm that Gr defects are necessary for Si intercalation at room temperature and show that a hypothetical intercalated silicene layer cannot be stable for more than 8 ps and that the corresponding Si atoms completely lose their in-plane order resulting in a random planar distribution and form strong covalent bonds with Ni atoms.

Published
2020
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29. RECENT RESULTS IN SILICON-CNT PHOTODETECTORS

Author

ARAMO, C., primary, Ambrosio, A., additional, Ambrosio, M., additional, Cilmo, M., additional, Guarino, F., additional, Maddalena, P., additional, Grossi, V., additional, Passacantando, M., additional, Santucci, S., additional, Nappi, E., additional, Tinti, A., additional, Valentini, A., additional, Fiandrini, E., additional, Pignatel, G., additional, Castrucci, P., additional, De Crescenzi, M., additional, and Scarselli, M., additional

Published
2012
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37. Administration of human msc?derived extracellular vesicles for the treatment of primary sclerosing cholangitis: Preclinical data in mdr2 knockout mice

Author

Angioni, R, Calì, B, Vigneswara, V, Crescenzi, M, Merino Rodriguez, Ana, Sánchez?rodríguez, R, Liboni, C, Hoogduijn, Martin, Newsome, PN, Muraca, M, Russo, FP, Viola, A, Angioni, R, Calì, B, Vigneswara, V, Crescenzi, M, Merino Rodriguez, Ana, Sánchez?rodríguez, R, Liboni, C, Hoogduijn, Martin, Newsome, PN, Muraca, M, Russo, FP, and Viola, A

Published
2020

38. Gas sensing with solar cells: The case of NH3 detection through nanocarbon/silicon hybrid heterojunctions

Author

Drera, Giovanni, Freddi, Sonia, Freddi, T., De Poli, Federico Alberto, Pagliara, Stefania, De Crescenzi, M., Castrucci, P., Sangaletti, Luigi Ermenegildo, Drera G. (ORCID:0000-0002-3871-9227), Freddi S. (ORCID:0000-0002-5157-881X), De Poli A., Pagliara S. (ORCID:0000-0003-2966-3361), Sangaletti L. (ORCID:0000-0001-9312-5862), Drera, Giovanni, Freddi, Sonia, Freddi, T., De Poli, Federico Alberto, Pagliara, Stefania, De Crescenzi, M., Castrucci, P., Sangaletti, Luigi Ermenegildo, Drera G. (ORCID:0000-0002-3871-9227), Freddi S. (ORCID:0000-0002-5157-881X), De Poli A., Pagliara S. (ORCID:0000-0003-2966-3361), and Sangaletti L. (ORCID:0000-0001-9312-5862)

Abstract

Photovoltaic (PV) cells based on single-walled carbon nanotube (SWCNT)/silicon (Si) and multiwalled carbon nanotube (MWCNT)/Si junctions were tested under exposure to NH3 in the 0–21 ppm concentration range. The PV cell parameters remarkably changed upon NH3 exposure, suggesting that these junctions, while being operated as PV cells, can react to changes in the environment, thereby acting as NH3 gas sensors. Indeed, by choosing the open-circuit voltage, VOC, parameter as read-out, it was found that these cells behaved as gas sensors, operating at room temperature with a response higher than chemiresistors developed on the same layers. The sensitivity was further increased when the whole current–voltage (I–V) curve was collected and the maximum power values were tracked upon NH3 exposure.

Published
2020

39. Dramatic efficiency boost of single-walled carbon nanotube-silicon hybrid solar cells through exposure to ppm nitrogen dioxide in air: An ab-initio assessment of the measured device performances

Author

Freddi, Sonia, Achilli, S., Soave, R., Pagliara, Stefania, Drera, Giovanni, De Poli, A., De Nicola, F., De Crescenzi, M., Castrucci, P., Sangaletti, Luigi Ermenegildo, Freddi S. (ORCID:0000-0002-5157-881X), Pagliara S. (ORCID:0000-0003-2966-3361), Drera G. (ORCID:0000-0002-3871-9227), Sangaletti L. (ORCID:0000-0001-9312-5862), Freddi, Sonia, Achilli, S., Soave, R., Pagliara, Stefania, Drera, Giovanni, De Poli, A., De Nicola, F., De Crescenzi, M., Castrucci, P., Sangaletti, Luigi Ermenegildo, Freddi S. (ORCID:0000-0002-5157-881X), Pagliara S. (ORCID:0000-0003-2966-3361), Drera G. (ORCID:0000-0002-3871-9227), and Sangaletti L. (ORCID:0000-0001-9312-5862)

Abstract

We observed a 73% enhancement of the power conversion efficiency (PCE) of a photovoltaic cell based on a single wall carbon nanotube/Si hybrid junction after exposing the device to a limited amount (10 ppm) of NO2 diluted in dry air. On the basis of a computational modeling of the junction, this enhancement is discussed in terms of both carbon nanotube (CNT) p-doping, induced by the interaction with the oxidizing molecules, and work function changes across the junction. Unlike studies so far reported, where the PCE enhancement was correlated only qualitatively to CNT doping, our study (i) provides a novel and reversible path to tune and considerably enhance the cell efficiency by a few ppm gas exposure, and (ii) shows computational results that quantitatively relate the observed effects to the electrostatics of the cell through a systematic calculation of the work function. These effects have been cross-checked by exposing the cell to reducing molecules (i.e·NH3) that resulted to be detrimental to the cell efficiency, consistently with the theoretical ab-initio calculations.

Published
2020

46. Development of new photon detection device for Cherenkov and fluorescence radiation

Author

Tinti A., Scarselli M., Santucci S., Pignatel G., Passacantando M., Nappi E., Guarino F., Grossi V., Maddalena P., Fiandrini E., Cilmo M., De Crescenzi M., Castrucci P., Ambrosio M., Battiston R., Aramo C., Ambrosio A., and Valentini A.

Subjects
Physics, QC1-999
Abstract

Recent progress on the development of a new solid state detector allowed the use of finely pixelled photocathodes obtained from silicon semiconductors. SiPM detectors seem to be an ideal tool for the detection of Cherenkov and fluorescence light in spite of their not yet resolved criticism for operating temperature and intrinsic noise. The main disadvantage of SiPM in this case is the poor sensitivity in the wavelength range 300-400 nm, where the Cherenkov light and fluorescence radiation are generated. We report on the possibility to realize a new kind of pixelled photodetector based on the use of silicon substrate with carbon nanotube compounds, more sensitive to the near UV radiation. Also if at the very beginning, the development of such detector appears very promising and useful for astroparticle physics, both in the ground based arrays and in the space experiments. The detectors are ready to be operated in conditions of measurements without signal amplification.

Published
2013
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