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1. Sociodemographic profile, health-related behaviours and experiences of healthcare access in Italian transgender and gender diverse adult population

Author

Marconi, M., Pagano, M. T., Ristori, J., Bonadonna, S., Pivonello, R., Meriggiola, M. C., Motta, G., Lombardo, F., Mosconi, M., Oppo, A., Cocchetti, C., Romani, A., Federici, S., Bruno, L., Verde, N., Lami, A., Crespi, C. M., Marinelli, L., Giordani, L., Matarrese, P., Ruocco, A., Santangelo, C., Contoli, B., Masocco, M., Minardi, V., Chiarotti, F., Fisher, A. D., and Pierdominici, M.

Published
2024
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6. A comment from SIGIS, SIE and SIAMS: “Puberty blockers in transgender adolescents—a matter of growing evidence and not of ideology”

Author

Ristori, J., primary, Motta, G., additional, Meriggiola, M. C., additional, Bettocchi, C., additional, Crespi, C., additional, Falcone, M., additional, Lombardo, F., additional, Maggi, M., additional, Morelli, G., additional, Colao, A. M., additional, Isidori, A. M., additional, and Fisher, A. D., additional

Published
2023
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8. Pegylated interferon α plus ribavirin for the treatment of chronic hepatitis C: A multicentre independent study supported by the Italian Drug Agency

Author

Mascolo, M.C., Cursaro, C., Scuteri, A., Ranieri, J., Monti, M., Bellentani, S., Gasbarrini, A., Pompili, M., Puoti, C., Bellis, L., Regazzetti, A., Maffezzini, E., Pietrangelo, A., Abbati, G., Raimondo, G., Scribano, L., Martines, D., Baroni, G. Svegliati, Faraci, G., Schianchi, S., Fornaciari, G., Fabris, P., Madonia, S., Civitavecchia, G., Pirisi, M., Smirne, C., Borghi, A., Sardini, C., Andreoletti, M., Morisco, F., Caporaso, N., Fargion, S., Fatta, E., Masutti, F., Bonaventura, M.E., Autolitano, A., Russello, M., Bellia, A., Toniutto, P., Bitetto, D., Mecenate, F., Pasulo, L., Lucà, M.G., Picardi, A., Vespasiani, U., Grattagliano, I., Palasciano, G., Romagno, D., Crespi, C., Gianstefani, A., Gobbo, G., Monti, V., Giannelli, G., Napoli, N., Nosotti, Raspanti, A., Cuccorese, Colombo, A.E., Floridia, Plattella, M.S., Cassano, P., Gentile, I., Blanc, P.L., Messina, V., Bonfante, S., Bellissima, P., Toti, M., Vecchiet, J., Falasca, K., Portelli, V., De Stefano, G., Pietromatera, G., Viganò, P., Re, T., Andreoni, M., Raineri, G., Massari, M., Grossi, P.A., Caputo, S., Cassola, G., Feasi, M., Foti, G., Kunkar, A., Corti, G., Baragli, F., Caterini, L., Migliorini, D., Chiodera, A., Calleri, G., Spezia, C., Baiguera, C., Puoti, M., Brancaccio, G., Gaeta, G.B., Vento, S., Di Biagio, A., Nicolini, L., Liberti, A., Iannece, M.D., Contini, C., Tacconi, D., Caremani, M., Almi, P., Chimenti, M., Cosco, Messeri, D., Esperti, F.C., Paffetti, A., Mastropietro, C., Moretti, A., Spagnolo, A.L., Lomonaco, L., Calì, A., Mandelli, G., Spinzi, G.C., Framarin, L., Berrutti, M., Boccia, S., Simone, L., Pazzi, P., Fornari, F., Comparato, G., Casetti, T., Foschi, F.G., Bertin, T., Salvagnini, M., Samori, A., Ferretti, E., Casiraghi, M.A., Marin, R., Ciancio, A., Campo, N., Testa, R., Rocco, A., Federico, A., Loguercio, C., Rizzo, S., Giannini, E.G., Corbo, M., Riegler, G., Esposito, P., Ricci, G.L., Rosina, Floriano, Tosti, Maria Elena, Borghesio, Elisabetta, Masocco, Maria, Mele, Alfonso, Coppola, Carmine, Milella, Michele, Borgia, Guglielmo, Andreone, Pietro, Koch, Maurizio, Zignego, Anna Linda, Romano, Mario, Carrara, Maurizio, Almasio, Piero Luigi, Azzola, Emilio, Nardone, Gerardo, Benedetti, Antonio, Carosi, Giampiero, Mazzotta, Francesco, Sagnelli, Evangelista, and Rizzetto, Mario

Published
2014
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12. Impact of chronic exposure to 5-alpha reductase inhibitors on the risk of hospitalization for COVID-19: A case-control study in male population from two COVID-19 regional centers of Lombardy, Italy

Author

Lazzeri, M., Duga, S., Azzolini, E., Fasulo, V., Buffi, N., Saita, A., Lughezzani, G., Paraboschi, E. M., Hurle, R., Nobili, A., Cecconi, M., Guazzoni, G., Casale, P., Asselta, R., Accornero, S., Aghemo, A., Alfarone, L., Ali, H., Aloise, M., Angelini, C., Arcari, I., Arosio, P., Baccarin, A., Badalamenti, S., Baggio, S., Balzarini, L., Barbagallo, M., Barberi, C., Barbic, F., Barbieri, V., Barbone, A., Basciu, A., Benvenuti, C., Bianchi, I., Bocciolone, M., Bonifacio, C., Borea, F., Borroni, M., Bresciani, G., Brunetta, E., Bulletti, C., Cadonati, C., Calabro', L., Calatroni, M., Caltagirone, G., Calvetta, A. A., Cannata, F., Canziani, L., Capogreco, A., Capretti, G. L., Carlani, E., Carrone, F., Casana, M., Castelli, A., Ceribelli, A., Ceriotti, C., Ciccarelli, M. C., Cimino, M., Citterio, G., Ciuffini, L., Colaizzi, C., Colapiet-Ro, F., Costa, G., Cozzi, O., Craviotto, V., Crespi, C., Crippa, M., D'Antuono, F., D'Orazio, F., Da Rio, L., Dal Farra, S., D'Antonio, F., De Ambroggi, G., De Donato, M., De Lucia, F., De Nittis, P., De Santis, M., Delle Rose, G., Desai, A., Di Pilla, M., Dipaola, F., Dipasquale, A., Droandi, G., Altieri, V., Fazio, R., Fedeli, C., Ferrante, G., Ferrara, E. C., Ferrari, M. C., Ferri, S., Folci, M., Foresti, S., Franchi, E., Fraolini, E., Furfaro, F., Galimberti, P., Galtieri, A., Gavazzi, F., and Generali, E.

Subjects
Male, SARS-CoV-2, Urology, COVID-19, Middle Aged, 5-alpha reductase inhibitors, Androgens, Sex, Hospitalization, Nephrology, Case-Control Studies, Humans, Female, Aged
Abstract

There are sex differences in vulnerability to Coronavirus disease 2019 (COVID-19). The coronavirus S protein mediates viral entry into target cells employing the host cellular serine protease TMPRSS2 for S-protein priming. The TMPRSS2 gene expression is responsive to androgen stimulation and it could partially explain sex differences. We hypothesized that men chronically exposed to 5-alpha reductase inhibitors (5ARIs) for benign prostate hyperplasia (BPH) have a lower risk of hospitalization for COVID-19.This is a population-based case-control study on consecutive patients positive for SARS-CoV-2 virus who required hospitalization for COVID-19 (cases), age-matched to beneficiaries of the Lombardy Regional Health Service (controls). Data were collected by two high-volume COVID-19 regional centers of Lombardy (Italy). The primary outcome was to compare the prevalence of patients chronically exposed to 5ARIs, who required hospitalization for COVID-19, with the one of controls.Overall, 943 males were enrolled; 45 (4.77%) were exposed to 5ARI. COVID-19 patients aged55 years under 5ARI treatment were significantly less than expected on the basis of the prevalence of 5ARI treatment among age-matched controls (5.57 vs. 8.14%; P=0.0083, 95% CI: 0.75-3.97%). This disproportion was higher for men aged65 (7.14 vs. 12.31%; P=0.0001, 95% CI: 2.83-6.97%). Eighteen 5ARIs-patients died; the mean age of men who died was higher than those who did not: 75.98±9.29 vs. 64.78±13.57 (P0.001). Cox-regression and multivariable models did not show correlation between 5ARIs exposure and protection against intensive care unit admission/death.Men exposed to 5ARIs might be less vulnerable to severe COVID-19, supporting its use in disease prophylaxis.

Published
2022

13. Differential diagnosis in chronic psychosis: a case report.

Author

Alcalde-Diosdado Crespi, C., Almodóvar Rivera, M. D. P., and Vílchez Español, F.

Abstract

Introduction: A colombian woman aged 62, with previous diagnosis of paranoid schizophrenia. She retired from working 2 years ago, when she started taking care of her sick husband full-time. Objectives: To describe a chronic psychosis case and discuss the treatment options and differential diagnosis. Methods: We used the face-to-face interviews during her last hospitalization and her electronic medical history. We also made a brief research about the effectiveness of risperidone depot in Pubmed. Results: Psychiatric history She's had 3 hospitalizations, all of them coincided with stressful vital situations. The first one occurred when she was dealing with a job issue. In the second one she was having an economic conflict with her husband. And the third one has coincided with worries about her retirement pension and her caregiver burden. Current episode She came to my hospital emergency department distressed because she thought her husband and her were victims of an international drug trafficking plot. She said a colombian drug cartel had sent 9 prostitutes to her village in order to steal from them, by pretending they were cleaning assistants, as a reprisal against her husband, who used to be a military in Colombia. She explained the nature of this event with great details. Also, she said the electric company was involved and they had tried to intoxicate her. The psychopathological exploration was altered with a correct speech in its form but incoherent in its content. She presented a highly structured delusional plot of prosecution. No major affective disorders were detected. She suffered from reactive insomnia and anxiety. Evolution At first, it was torpid, she felt perspicacious and angry about the admission. Later, as the antipsychotic started to work, the symptoms improved and she became calm and collaborative. She has never criticized the delusion plot, but it was encapsulated, and the affective resonance disappeared. We tried oral aripiprazole and paliperidone but retired both due to bad tolerance. Then we tried risperidone, with good tolerance and response, and started her current monthly treatment with Risperidone 100 mg depot. After one year, she has kept stable with no relapses and good adherence to the treatment. Differential diagnosis The patient meets every diagnostic criteria of Delusional disorder (F22), as she has never experienced hallucinations and the functionality has not significantly decreased through the years. Also, she doesn't meet the second criteria for Schizophrenia (F20). Conclusions: It is important to explore the evolution of a psychotic disorder in order to differentiate between a schizophrenia and a delusional disorder, as the prognosis differs significantly. Using Risperidone monthly depot can be a good option for treating a psychotic disorder (Sampson et al. Cochrane Database Syst Rev 2016. 14;4(4)). Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Published
2024
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19. Shape Coexistence at Zero Spin in Ni 64 Driven by the Monopole Tensor Interaction

Author

N. Mărginean, D. Little, Y. Tsunoda, S. Leoni, R. V. F. Janssens, B. Fornal, T. Otsuka, C. Michelagnoli, L. Stan, F. C. L. Crespi, C. Costache, R. Lica, M. Sferrazza, A. Turturica, A. D. Ayangeakaa, K. Auranen, M. Barani, P. C. Bender, S. Bottoni, M. Boromiza, A. Bracco, S. Călinescu, C. M. Campbell, M. P. Carpenter, P. Chowdhury, M. Ciemała, N. Cieplicka-Oryǹczak, D. Cline, C.

Published
2020
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20. THE AUTHORS REPLY

Author

Kheifets, L., Ahlbom, A., Crespi, C. M., Feychting, M., Johansen, C., Monroe, J., Schüz, J., Murphy, M. F. G., Oksuzyan, S., Preston-Martin, S., Roman, E., Saito, T., Savitz, D., Simpson, J., Swanson, J., Tynes, T., Verkasalo, P., and Mezei, G.

Published
2011
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21. P-01-4 A New Tool to Explore Brain Functional Basis of Gender Disphoria: Validation of a Functional MRI Protocol to Investigate Patterns of Brain Activation Related to Body Image and Gender Identity

Author

Ceruti, C., primary, D'Agata, F., additional, Bergui, M., additional, Sibona, M., additional, Preto, M., additional, Gualerzi, A., additional, Crespi, C., additional, Cicerale, A., additional, Diano, M., additional, Timpano, M., additional, Falcone, M., additional, Sedigh, O., additional, Fontana, D., additional, Rolle, L., additional, Motta, G., additional, Manieri, C., additional, Lanfranco, F., additional, Gontero, P., additional, and Molo, M.T., additional

Published
2020
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26. Meeting abstracts

Author

Agnifili A., Gola P., Guadagni S., Verzaro R., Carducci G., Gianfelice F., Ibi I., Marino M., Mancini E., De Bernardinis G., Allegri C., Spoletini F., Mariotti V., Vari A., Polinari U., Altomare D. F., Brienza E., Rinaldi M., Vicente-Prieta R., Memeo V., Bertolino F., Ceccopieri B., Nasi P. G., Porcellana V., Mattio R., Forconi S., Dellepiane M., Biccari V., Tedesco M., Matrone A. M., Sirovich I., Nicolanti V., Stipa S., Bonalumi U., Galleano R., Baiardi A., Balbi P., Simoni G., Calleri G., Casaldi, V., Cosimelli, M., Giannarelli, D., Botti, C., Mannella, E., Wappner, G., Cavaliere, R., Casale, V., Fracasso, P., Grassi, A., Lapenta, R., Stigliano, V., Nasi P. G., Cianciulli A. M., Antonaci S., Casale V., Greco C., Gandolfo G. M., Coco, C., Giordano, A., Roncolini, G., Mattana, C., Coppola, R., Magistrelli, P., Crespi C., De Giorgio A. M., Giuliani A., Galasso V., Truglia S., De Ligio F., De Ligio S., Serafino L., Limiti R., Arrabito G., Guadagni S., Palumbo G., Pantaleoni G., D'Alessandro V., Agnifili A., Carducci G., Mancini E., Marino M., Gola P., Gianfelice F., Verzaro R., Ibi I., Ranalletta D., Fanini R., De Bernardinis G., Huscher, C., Chiodini, S., Zamboni, F., Montorsi, M., Marchese C., Bertolino F., Ceccopieri B., Locatelli L., Mareni C., Mattio R., Scaglione D., Vanzetti M., Mascagni, D., Di Matteo, G., Hojo, K., Moriya, Y., Sugihara, K., Massidda, B., Nicolosi, A., Tarquini, A., Natalini, G., Borgognoni, F., Ranieri, S., Menculini, M., Carioni, G., Botti C., Cosimelli M., Casaldi V., Cavaliere R., Caporossi M., Huguet C., Chiavellati L., Cavallaro A., Pietroletti, R., Cianca, G., Barnabei, R., Simi, M., Romano G., Di Carlo A., Mariano A., D'Alessandro V., Rotondano G., Macchia V., Secco, G. B., Fardelli, R., Zoli, S., Lapini, C., Cariati, A., Prior, C., Sironi, I., Mietti, G., Arisi, B. A., Ferrari, G. C., Gasbacortat, M., Brusamolino, R., Bauer, D., Russo, A., Spinelli C., Berti P., Gori L., Materazzi G., Mucci M., Pierallini S., Miccoli P., Cosimeili M., Mannella E., Valabrega, S., Pozzi, G., De Angelis, R., D'Angelo, F., Indinnimeo, M., Aurello, P., Tabbi, P., Fegiz, G., Venezia, P., Colella, R., Pitzalis, M. V., Pitzalis, M., Vuolo, G., Di Cosmo, L., Grimaldi, L., Maglio, C., Masellis, D., and Carli, A.

Published
1994
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30. La presa in carico Psicosessuologica nella disforia di genere: una rassegna della letteratura

Author

PRUNAS, ANTONIO, Crespi, C, Nadalin, DA, Prunas, A, Crespi, C, and Nadalin, D

Subjects
disforia di genere, trattamento ormonale, riassegnazione chirurgica del sesso, consulenza sessuologica
Abstract

Il trattamento ormonale e l’intervento di Riassegnazione Chirurgica del Sesso (RCS) sono da sempre considerati i trattamenti di scelta per le persone con Disforia di Genere ed entrambi i trattamenti hanno una ricaduta importante non solo sulla qualità della vita ma anche sull’equilibrio psicologico ed in particolare sulla funzione sessuale. Secondo le linee guida della World Professional Association Transgender Health (WPATH, 2011) emerge come da un lato vi siano molti individui che richiedono sia cure ormonali che chirurgiche per alleviare la loro disforia di genere, mentre altri necessitano solo di uno di questi trattamenti ed alcuni di nessuno (Bockting & Goldberg, 2006; Bockting, 2008; Lev, 2004). Quindi il trattamento della Disforia di Genere è diventato molto più specifico per ogni individuo ed anche le consulenze sessuologiche sono sempre più diversificate a seconda delle esigenze delle persone. La prima cosa da considerare è che ogni intervento medico e chirurgico effettuato insieme alla persona con Disforia di Genere porta con sé profonde ripercussioni non solo sulla vita psicologica e relazionale ma soprattutto sulla funzione sessuale e sulla conseguente qualità di essa. Quindi è importante effettuare consulenze sessuologiche specifiche a seconda delle esigenze delle persone discutendo con loro l’impatto della terapia ormonale e dell’intervento chirurgico sulla funzione sessuale

Published
2016

31. Immune inflammation indicators and ALBI score to predict occurrence and recurrence of hepatocellular carcinoma in HCV-related cirrhosis treated with direct-acting antivirals

Author

Gardini, A.C., primary, Foschi, F.G., additional, Conti, F., additional, Petracci, E., additional, Marisi, G., additional, Buonfiglioli, F., additional, Ravaioli, M., additional, Mazzella, G., additional, Muratori, P., additional, Lenzi, M., additional, Crespi, C., additional, Bolondi, L., additional, Badia, L., additional, Verucchi, G., additional, Vitale, G., additional, Vukotic, R., additional, Brillanti, S., additional, and Andreone, P., additional

Published
2018
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33. Nivel de sospecha de enfermedad de Fabry en profesionales de la salud en el primer nivel de atención : Buenos Aires, mayo 2015

Author

Arce, Mariana, Scoccia, A. M., Lembo, Julia, Crespi, C. A., and Moiso, Adriana

Subjects
Enfermedad de Fabry, Ciencias Médicas, Personal de Salud
Abstract

La enfermedad de Fabry es una enfermedad genética, hereditaria autosómica recesiva, de depósito lisosomal. Pertenece a los errores innatos del metabolismo. La incidencia varía de 1/40.000 a 1/117.000 nacidos vivos. Causa deficiencia total o parcial de la enzima alfa-galactosidasa A. Esta deficiencia interfiere en la degradación de globotriaosilceramida (Gb3), presente en muchos tipos de células, particularmente en las membranas de los eritrocitos. Los signos y síntomas sugestivos de E. de Fabry son: dolor intenso en manos y pies, dolor abdominal, angioqueratomas, opacidad corneal, facie tosca, proteinuria, entre otras. El compromiso vascular aumenta 12 veces el riego de ACV a partir de los 30 años, además de causar distintas afecciones cardíacas. La progresión del daño en el rinón evoluciona a insuficiencia renal crónica con necesidad de diálisis en la tercera década de la vida. Por todo lo expuesto es muy importante la detección temprana de esta enfermedad para instaurar un tratamiento adecuado con el objetivo de detener el deterioro de los órganos antes mencionados y reducir de esta forma la morbimortalidad de la Enfermedad de Fabry., Facultad de Ciencias Médicas

Published
2016

38. The Ekman 60-faces test: an italiana normative study

Author

Dodich, A, Cerami, C, Crespi, C, Canessa, N, Marcone, A, Arpone, M, Cappa, S., REALMUTO, Sabrina, Dodich, A, Cerami, C, Crespi, C, Canessa, N, Marcone, A, Arpone, M, Realmuto, S, and Cappa, S

Subjects
Settore MED/26 - Neurologia, ekman test
Published
2012

40. Pegylated interferon α plus ribavirin for the treatment of chronic hepatitis C: A multicentre independent study supported by the Italian Drug Agency

Author

Rosina, Floriano, Tosti, Maria Elena, Borghesio, Elisabetta, Masocco, Maria, Mele, Alfonso, Coppola, Carmine, Milella, Michele, Borgia, Guglielmo, Andreone, Pietro, Koch, Maurizio, Zignego, Anna Linda, Romano, Mario, Carrara, Maurizio, Almasio, Piero Luigi, Azzola, Emilio, Nardone, Gerardo, Benedetti, Antonio, Carosi, Giampiero, Mazzotta, Francesco, Sagnelli, Evangelista, Rizzetto, Mario, Mascolo, M. C., Cursaro, C., Scuteri, A., Crespi, C., Gianstefani, A., Ranieri, J., Monti, M., Corti, G., Blanc, P. L., Baragli, F., Bellentani, S., Gasbarrini, A., Pompili, M., Mecenate, F., Picardi, A., Vespasiani, U., Nosotti, Null, Null, A. Picardi, Ricci, G. L., Paffetti, A., Mastropietro, C., Moretti, A., Spagnolo, A. L., Puoti, C., Bellis, L., Regazzetti, A., Maffezzini, E., Pietrangelo, A., Abbati, G., Borghi, A., Sardini, C., Raimondo, G., Scribano, L., Martines, D., Svegliati Baroni, G., Faraci, G., Schi anchi, S., Fornaciari, G., Massari, M., Fabris, P., Bertin, T., Salvagnini, M., Madonia, S., Calì, A., Civitavecchia, G., Pirisi, M., Smirne, C., Andreoletti, M., Morisco, F., Caporaso, N., Gentile, I., Brancaccio, G., Gaeta, G. B., Liberti, A., Iannece, M. D., Rocco, A., Federico, A., Loguercio, C., Riegler, G., Esposito, P., Fargion, S., Fatta, E., Masutti, F., Bonaventura, M. E., Autolitano, A., Russello, M., Bellia, A., Toniutto, P., Bitetto, D., Pasulo, L., Lucà, M. G., Grattagliano, I., Palasciano, G., Romagno, D., Giannelli, G., Napoli, N., Plattella, M. S., Cassano, P., Gobbo, G., Monti, V., Raspanti, A., Cuccorese, Null, Colombo, A. E., Mandelli, G., Spinzi, G. C., Floridia, Null, Messina, V., Bonfante, S., Bellissima, P., Toti, M., Vecchiet, J., Falasca, K., Portelli, V., Stefano, G. De, Pietromatera, G., Viganò, P., Re, T., Andreoni, M., Null, G. Raineri, Grossi, P. A., Caputo, S., Cassola, G., Feasi, M., Biagio, A. Di, Nicolini, LAURA AMBRA, Giannini, EDOARDO GIOVANNI, Corbo, M., Foti, G., Kunkar, A., Caterini, L., Migliorini, D., Chiodera, A., Calleri, G., Spezia, C., Framarin, L., Null, M. Berrutti, Ciancio, A., Baiguera, C., Puoti, M., Vento, S., Contini, C., Boccia, S., Casiraghi, M. A., Simone, L., Tacconi, D., Caremani, M., Almi, P., Chimenti, M., Cosco, Null, Messeri, D., Esperti, F. C., Lomonaco, L., Pazzi, P., Fornari, F., Comparato, G., Casetti, T., Foschi, F. G., Samori, A., Ferretti, E., Marin, R., Campo, N., Testa, R., Rizzo, S., Rosina, F, Tosti, ME, Borghesio, E, Masocco, M, Mele, A, Coppola, C, Milella, M, Borgia, G, Andreone, P, Koch, M, Zignego, AL, Romano, M, Carrara, M, Almasio, PL, Azzola, E, Nardone, G, Benedetti, A, Carosi, G, Mazzotta, F, Sagnelli, E, Rizzetto, M, Rosina, F., Tosti, M. E., Borghesio, E., Masocco, M., Mele, A., Coppola, C., Milella, M., Borgia, Guglielmo, Andreone, P., Koch, M., Zignego, A. L., Romano, M., Carrara, M., Almasio, P. L., Azzola, E., Nardone, GERARDO ANTONIO PIO, Benedetti, A., Carosi, G., Mazzotta, F., Sagnelli, E., Rizzetto, M., Aifa, Aisf, Simit, Aigo, Sige, Gentile, Ivan, Morisco, Filomena, Et, Al, Floriano Rosina, Maria Elena Tosti, Elisabetta Borghesio, Maria Masocco, Alfonso Mele, Carmine Coppola, Michele Milella, Guglielmo Borgia, Pietro Andreone, Maurizio Koch, Anna Linda Zignego, Mario Romano, Maurizio Carrara, Piero Luigi Almasio, Emilio Azzola, Gerardo Nardone, Antonio Benedetti, Giampiero Carosi, Francesco Mazzotta, Evangelista Sagnelli, and Mario Rizzetto

Subjects
Registrie, Male, Cirrhosis, medicine.disease_cause, Polyethylene Glycol, Gastroenterology, Polyethylene Glycols, chemistry.chemical_compound, Hepatitis Viruses, Hepatitis Viruse, Prospective Studies, Viral, Registries, Chronic, Prospective cohort study, Drug Carrier, Drug Carriers, Settore MED/12 - Gastroenterologia, Medicine (all), Recombinant Protein, Middle Aged, Hepatitis C, Recombinant Proteins, Treatment Outcome, Italy, Combination, RNA, Viral, Population study, Drug Therapy, Combination, Female, Human, medicine.medical_specialty, Genotype, Hepatitis C virus, Alpha interferon, Ribavirin, Sustained virological response (SVR), Treatment, Antiviral Agents, Follow-Up Studie, Hepatology, Drug Therapy, Internal medicine, medicine, Humans, Antiviral Agent, business.industry, Interferon-alpha, HCV therapy, Hepatitis C, Chronic, medicine.disease, Clinical trial, Prospective Studie, chemistry, Immunology, RNA, Follow-Up Studies, business
Abstract

a b s t r a c t Background: Data on the efficacy of Peg-interferon/ribavirin therapy for chronic hepatitis C are mostly derived from treatment of selected patients enrolled in clinical trials. This study aimed to assess the effectiveness of Peg-interferon/ribavirin therapy in “real world” chronic hepatitis C patients in Italy. Methods: Independent observational multicentre study including consecutive patients receiving Peginterferon/ribavirin in the 18 months before (retrospective phase) and after (prospective phase) the start of the study. Results: 4176 patients were eligible. The final study population consisted of 2051 patients in the retrospective and 2073 in the prospective phase. Sustained virological response was achieved by 1036 patients (50.5%) during the retrospective phase: 325 were genotypes 1/4 (34.1%) and 684 were genotypes 2/3 (67.2%) and by 800 patients (38.6%) during the prospective phase: 300 were genotypes 1/4 (28.4%) and 473 were genotypes 2/3 (51.5%). During multivariate analysis genotypes 2/3 were significantly associated with higher sustained virological response rates; cirrhosis and -glutamil-transpeptidase >2 times the normal limit were associated with poorer response. Conclusions: The response to Peg-interferon/ribavirin therapy in “real world” clinical practice is distinctly lower than in registration trials. The difference in response rates was more pronounced among easy-totreat than among difficult-to-treat hepatitis C virus genotypes.

Published
2014

41. Direct acting antivirals for the treatment of elderly patients with HCV advanced disease in the real life practice

Author

Conti, F., primary, Scuteri, A., additional, Vitale, G., additional, Lazzarini, G., additional, Porro, A., additional, Muratori, P., additional, Serio, I., additional, Buonfiglioli, F., additional, Badia, L., additional, Lanzi, A., additional, Mastroroberto, M., additional, Appolloni, L., additional, Morotti, M., additional, Morelli, M.C., additional, Foschi, F.G., additional, Verucchi, G., additional, Brillanti, S., additional, Crespi, C., additional, Lenzi, M., additional, Mazzella, G., additional, and Andreone, P., additional

Published
2016
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42. Treatment with direct acting antiviral agents-based regimen in HCV patients with advanced liver disease: Analysis of an Italian multicenter observational study

Author

Conti, F., primary, Scuteri, A., additional, Di Donato, R., additional, Lazzarini, G., additional, Porro, A., additional, Muratori, P., additional, Serio, I., additional, Buonfiglioli, F., additional, Badia, L., additional, Lanzi, A., additional, Mastroroberto, M., additional, Appolloni, L., additional, Morotti, M., additional, Morelli, M.C., additional, Foschi, F.G., additional, Verucchi, G., additional, Brillanti, S., additional, Crespi, C., additional, Lenzi, M., additional, Mazzella, G., additional, and Andreone, P., additional

Published
2016
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44. Patents and literature

Author

Linhardt, Robert J., Baker P. E., Crespi C. L., Thilly W. G., Daemer R. J., Feinstone S. M., Gust I. D., Purcell R. H., Fabricius H., Stahn R., Fischer H., Kickhofen B., Vaubel E., Healy G. M., Curry K. D., Horodniceanu F., LeFur R., Izawa M., Tatsukawa S., Jacobson B., Raymond L., Kasai S., Akaike T., Miyata T., Maldonado R. L., Rosanoff K. A., Mears D. C., Meyers W. E., Beck L. R., Montagnon B. J., Fanget B. J. C., Nees S., Nobuhara M., Yamaguchi K., Mochida E., Noll L. A., O’Connell D. M., Ooi K., Morita M., Suzuki K., Hashizume S., Yoshizawa H., Peterson A., Walum E., Rotman M. B., Tolbert W. R., Feder J., Lewis C., Yamane I., Kan M., and Minamoto Y.

Published
1986
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