8 results on '"Crestelo-Vieitez, Anxela"'
Search Results
2. Gender-Based Differences by Age Range in Patients Hospitalized with COVID-19: A Spanish Observational Cohort Study
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Josa Laorden, Claudia, Crestelo Vieitez, Anxela, García Andreu, María, Rubio-Rivas, Manuel, Sánchez, Marcos, Toledo Samaniego, Neera, Arnalich Fernández, Francisco, Iguaran Bermudez, Rosario, Fonseca Aizpuru, Eva, Vargas Núñez, Juan Antonio, Pesqueira Fontan, Paula Maria, Serrano Ballesteros, Jorge, Freire Castro, Santiago, Pestaña Fernández, Melani, Viana García, Alba, Nuñez Rodriguez, Victoria, Giner Galvañ, Vicente, Carrasco Sánchez, Francisco, Hernández Milián, Almudena, Cobos Siles, Marta, Napal Lecumberri, Jose, Herrero García, Virginia, Pascual Pérez, Maria, Millán Núñez-Cortés, Jesús, Casas Rojo, José, SEMI-COVID-19 Network, UAM. Departamento de Medicina, and Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)
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medicine.medical_specialty ,Multivariate analysis ,Medicina ,medicine.medical_treatment ,coronavirus ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Lower risk ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,medicine ,Factors sexuals en les malalties ,030212 general & internal medicine ,Espanya ,Mechanical ventilation ,business.industry ,SARS-CoV-2 ,Mortality rate ,lcsh:R ,COVID-19 ,General Medicine ,Intensive care unit ,gender differences ,Spain ,Sex factors in disease ,Observational study ,Complication ,business ,Cohort study - Abstract
There is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12,063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; p < 001). Bilateral condensation was more frequent among men than women (31.8% vs. 29.9%; p = 0.007). The men needed non-invasive and invasive mechanical ventilation more frequently (5.6% vs. 3.6%, p < 0.001, and 7.9% vs. 4.8%, p < 0.001, respectively). The most prevalent complication was acute respiratory distress syndrome, with severe cases in 19.9% of men (p < 0.001). In men, intensive care unit admission was more frequent (10% vs. 6.1%; p < 0.001) and the mortality rate was higher (23.1% vs. 18.9%; p < 0.001). Regarding mortality, the differences by gender were statistically significant in the age groups from 55 years to 89 years of age. A multivariate analysis showed that female sex was significantly and independently associated with a lower risk of mortality in our study. Male sex appears to be related to worse progress in COVID-19 patients and is an independent prognostic factor for mortality. In order to fully understand its prognostic impact, other factors associated with sex must be considered.
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- 2021
- Full Text
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3. Severity scores in COVID-19 pneumonia: a multicenter, retrospective, cohort study
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Artero, Arturo, Madrazo, Manuel, Fernández-Garcés, Mar, Muiño Miguez, Antonio, González García, Andrés, Crestelo Vieitez, Anxela, García Guijarro, Elena, Fonseca Aizpuru, Eva María, García Gómez, Miriam, Areses Manrique, María, Martinez Cilleros, Carmen, Fidalgo Moreno, María Del Pilar, Loureiro Amigo, José, Gil Sánchez, Ricardo, Rabadán Pejenaute, Elisa, Abella Vázquez, Lucy, Cañizares Navarro, Ruth, Solís Marquínez, Marta Nataya, Carrasco Sánchez, Francisco Javier, González Moraleja, Julio, Montero Rivas, Lorena, Escobar Sevilla, Joaquín, Martín Escalante, María Dolores, Gómez-Huelgas, Ricardo, Ramos-Rincón, José Manuel, and SEMI-COVID-19 Network
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Male ,community-acquired pneumonia ,Organ Dysfunction Scores ,medicine.medical_treatment ,01 natural sciences ,Severity of Illness Index ,law.invention ,Cohort Studies ,0302 clinical medicine ,qSOFA ,Community-acquired pneumonia ,law ,PSI ,030212 general & internal medicine ,Hospital Mortality ,Original Research ,CURB-65 ,food and beverages ,Prognosis ,Intensive care unit ,Community-Acquired Infections ,Intensive Care Units ,Viral pneumonia ,Female ,COVID-19 ,COVID-19, CURB-65, PSI, community-acquired pneumonia, qSOFA ,medicine.medical_specialty ,Communicable Diseases ,03 medical and health sciences ,Internal medicine ,Internal Medicine ,medicine ,Humans ,0101 mathematics ,Aged ,Retrospective Studies ,Mechanical ventilation ,Receiver operating characteristic ,business.industry ,SARS-CoV-2 ,fungi ,010102 general mathematics ,Retrospective cohort study ,Pneumonia ,medicine.disease ,business - Abstract
BACKGROUND: Identification of patients on admission to hospital with coronavirus infectious disease 2019 (COVID-19) pneumonia who can develop poor outcomes has not yet been comprehensively assessed. OBJECTIVE: To compare severity scores used for community-acquired pneumonia to identify high-risk patients with COVID-19 pneumonia. DESIGN: PSI, CURB-65, qSOFA, and MuLBSTA, a new score for viral pneumonia, were calculated on admission to hospital to identify high-risk patients for in-hospital mortality, admission to an intensive care unit (ICU), or use of mechanical ventilation. Area under receiver operating characteristics curve (AUROC), sensitivity, and specificity for each score were determined and AUROC was compared among them. PARTICIPANTS: Patients with COVID-19 pneumonia included in the SEMI-COVID-19 Network. KEY RESULTS: We examined 10,238 patients with COVID-19. Mean age of patients was 66.6 years and 57.9% were males. The most common comorbidities were as follows: hypertension (49.2%), diabetes (18.8%), and chronic obstructive pulmonary disease (12.8%). Acute respiratory distress syndrome (34.7%) and acute kidney injury (13.9%) were the most common complications. In-hospital mortality was 20.9%. PSI and CURB-65 showed the highest AUROC (0.835 and 0.825, respectively). qSOFA and MuLBSTA had a lower AUROC (0.728 and 0.715, respectively). qSOFA was the most specific score (specificity 95.7%) albeit its sensitivity was only 26.2%. PSI had the highest sensitivity (84.1%) and a specificity of 72.2%. CONCLUSIONS: PSI and CURB-65, specific severity scores for pneumonia, were better than qSOFA and MuLBSTA at predicting mortality in patients with COVID-19 pneumonia. Additionally, qSOFA, the simplest score to perform, was the most specific albeit the least sensitive.
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- 2020
4. ENFERMEDAD HEPATICA GRASA NO ALCOHÓLICA Y FIBROSIS HEPÁTICA; RELACIÓN CON EL RIESGO CARDIOVASCULAR EN UNA POBLACIÓN DE ZARAGOZA Y SU DIAGNÓSTICO MEDIANTE ÍNDICES INDIRECTOS
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Crestelo Vieitez, Anxela and Bandrés Nivela, Orosia
- Abstract
Introducción; La enfermedad de hígado graso no alcohólica (EHGNA) es una patología cada vez más prevalente en todo el mundo y afecta en torno a un 25% de la población adulta mundial. Esto es debido a su relación cada vez más demostrada con el síndrome metabólico que también ha presentado un importante aumento de su incidencia en los últimos años. Además de la morbimortalidad asociada a la enfermedad hepática, se ha demostrado que los pacientes con EGHNA presentan mayor morbimortalidad cardiovascular, según estudios recientes. por tanto, esta patología debe considerarse como una condición englobada dentro de un síndrome cardio-metabolico con implicaciones importantes para la estratificación de riesgos en estos pacientes.Material y métodos; Se diseñó un estudio de tipo observacional descriptivo-analítico para responder a los objetivos propuestos. El análisis comparativo trata de buscar una correlación positiva (o no) entre diferentes parámetros antropométricos y analíticos en aquellos pacientes que padecen EGHNA y su relación con factores de riesgo cardiovascular. Además, se pretende relacionar los diferentes índices o escalas que miden de forma indirecta la esteatosis y la fibrosis de los pacientes con pruebas más exactas que proporcionan un diagnóstico de mayor certeza.Resultados; Se incluyeron 119 pacientes, con edad media de 54,8 años, siendo un 61% mujeres. El porcentaje de pacientes que presentó un riesgo cardiovascular elevado medido por índice SCORE fue del 25,2%, y las variables edad > o = 65 (OR 126, p =0,000), sexo masculino (OR 46, p= 0,001) e HTA (OR 6,97, p=0,005), fueron las que mostraron asociación estadísticamente significativa con mayor riesgo cardiovascular en pacientes con esteatosis. El índice indirecto NAFLD presentó un alto valor predictivo negativo y una asociación significativa con una p 30, perímetro de cintura elevado e HTA. El Fibroscan© fue la prueba utilizada como gold standard en el estudio, y se observó que las variables peso elevado (p=0,021), IMC alto (p=0,05), y alteraciones de transaminasas (GOT (p=0,006) y GPT(p=0,004)), mostraron asociación estadísticamente significativa con la presencia de fibrosis.Conclusiones: La EGHNA se asocia con un mayor riesgo cardiovascular en la población, afectando a pacientes jóvenes. El índice FLI para predecir esteatosis es más sensible y el índice NAFLD para fibrosis es más específico cuando se comparan con elastografía. Es necesario plantear algoritmos de diagnóstico, seguimiento, y tratamiento mediante equipos multidisciplinares en la atención a estos pacientes, debido al importante riesgo cardiovascular que presentan.
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- 2020
5. Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study.
- Author
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Artero, Arturo, Madrazo, Manuel, Fernández-Garcés, Mar, Muiño Miguez, Antonio, González García, Andrés, Crestelo Vieitez, Anxela, García Guijarro, Elena, Fonseca Aizpuru, Eva María, García Gómez, Miriam, Areses Manrique, María, Martinez Cilleros, Carmen, Fidalgo Moreno, María del Pilar, Loureiro Amigo, José, Gil Sánchez, Ricardo, Rabadán Pejenaute, Elisa, Abella Vázquez, Lucy, Cañizares Navarro, Ruth, Solís Marquínez, Marta Nataya, Carrasco Sánchez, Francisco Javier, and González Moraleja, Julio
- Subjects
COVID-19 ,OBSTRUCTIVE lung diseases ,ACUTE kidney failure ,ADULT respiratory distress syndrome ,RECEIVER operating characteristic curves - Abstract
Background: Identification of patients on admission to hospital with coronavirus infectious disease 2019 (COVID-19) pneumonia who can develop poor outcomes has not yet been comprehensively assessed. Objective: To compare severity scores used for community-acquired pneumonia to identify high-risk patients with COVID-19 pneumonia. Design: PSI, CURB-65, qSOFA, and MuLBSTA, a new score for viral pneumonia, were calculated on admission to hospital to identify high-risk patients for in-hospital mortality, admission to an intensive care unit (ICU), or use of mechanical ventilation. Area under receiver operating characteristics curve (AUROC), sensitivity, and specificity for each score were determined and AUROC was compared among them. Participants: Patients with COVID-19 pneumonia included in the SEMI-COVID-19 Network. Key results: We examined 10,238 patients with COVID-19. Mean age of patients was 66.6 years and 57.9% were males. The most common comorbidities were as follows: hypertension (49.2%), diabetes (18.8%), and chronic obstructive pulmonary disease (12.8%). Acute respiratory distress syndrome (34.7%) and acute kidney injury (13.9%) were the most common complications. In-hospital mortality was 20.9%. PSI and CURB-65 showed the highest AUROC (0.835 and 0.825, respectively). qSOFA and MuLBSTA had a lower AUROC (0.728 and 0.715, respectively). qSOFA was the most specific score (specificity 95.7%) albeit its sensitivity was only 26.2%. PSI had the highest sensitivity (84.1%) and a specificity of 72.2%. Conclusions: PSI and CURB-65, specific severity scores for pneumonia, were better than qSOFA and MuLBSTA at predicting mortality in patients with COVID-19 pneumonia. Additionally, qSOFA, the simplest score to perform, was the most specific albeit the least sensitive. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
6. La irisina y su relación con el metabolismo energético durante el ejercicio
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Crestelo Vieitez, Anxela and Soria Aznar, Marisol
- Abstract
Introducción: La irisina fue descubierta en el año 2012 por un grupo de investigadores que observaron una transformación del tejido adiposo blanco en tejido adiposo marrón a través de una vía hasta entonces desconocida, promovida por el ejercicio. Esto provocaba un aumento de la capacidad termogénica del tejido adiposo blanco, y todo ello fue atribuido a una nueva hormona a la que denominaron irisina. Los estudios pioneros le otorgaron unos efectos beneficiosos muy prometedores sobre el metabolismo energético, el glucolípidico, y también efectos protectores sobre enfermedades, como el alzheimer, y en consecuencia, numerosos estudios han intentado detallar la fisiología de la irisina, pero los resultados arrojados son contradictorios, llegando a cuestionarse la existencia de esta hormona. Esta revisión pretende actualizar la infomación sobre el tema y presentar y comparar los resultados de diferentes estudios sobre la irisina, y más específicamente, sobre su relación con el metabolismo energético durante el ejercicio. Material y métodos: se realiza una búsqueda bibliográfica en varios bases de datos, utilizando como herramienta principal PubMed, recopilando artículos originales, revisiones y metaanálisis recientes, pertenecientes a los últimos 10 años. Resultados: Los hallazgos contradictorios referentes a la función de la irisina y a sus mecanismos de regulación y secreción son una constante a lo largo de la bibliografía consultada. Los efectos del ejercicio sobre FNDC5/irisina en modelos animales han sido demostrados, pero en humanos estos efectos no son generalizables y sus funciones son cuestionables, por lo que es necesario un número mucho mayor de estudios para demostrarlo. Así mismo, los mecanismos de procesamiento y medición de la irisina así como la identificación de los receptores y las vías mediante las que esta hormona ejerce su acción requieren también mayor investigación. Aun así, la irisina parece tener efectos beneficiosos en el organismo, por lo que la investigación futura puede ser clave para su uso terapéutico. Conclusiones: la irisina es una hormona secretada en varios lugares del organismo con diferentes órganos diana, cuyos efectos beneficiosos han sido objetivados en modelos animales aunque con ciertas discrepancias en humanos. Por otro lado, a la vista de los resultados obtenidos en esta revisión, es probable que existan factores adicionales que ayuden y condicionen a la irisina en sus funciones sobre el metabolismo.
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- 2017
7. The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals.
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Mateos González, María, Sierra Gonzalo, Elena, Casado Lopez, Irene, Arnalich Fernández, Francisco, Beato Pérez, José Luis, Monge Monge, Daniel, Vargas Núñez, Juan Antonio, García Fenoll, Rosa, Suárez Fernández, Carmen, Freire Castro, Santiago Jesús, Mendez Bailon, Manuel, Perales Fraile, Isabel, Madrazo, Manuel, Pesqueira Fontan, Paula Maria, Magallanes Gamboa, Jeffrey Oskar, González García, Andrés, Crestelo Vieitez, Anxela, Fonseca Aizpuru, Eva María, Aranguren Arostegui, Asier, and Coduras Erdozain, Ainara
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COVID-19 ,PROGNOSIS ,BLOOD cell count ,ADULT respiratory distress syndrome ,BLOOD cells - Abstract
Objectives: A decrease in blood cell counts, especially lymphocytes and eosinophils, has been described in patients with serious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but there is no knowledge of their potential role of the recovery in these patients' prognosis. This article aims to analyse the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Design: This work was a retrospective, multicentre cohort study of 9644 hospitalised patients with confirmed COVID-19 from the Spanish Society of Internal Medicine's SEMI-COVID-19 Registry. Setting: This study examined patients hospitalised in 147 hospitals throughout Spain. Participants: This work analysed 9644 patients (57.12% male) out of a cohort of 12,826 patients ≥18 years of age hospitalised with COVID-19 in Spain included in the SEMI-COVID-19 Registry as of 29 May 2020. Main outcome measures: The main outcome measure of this work is the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Univariate analysis was performed to determine possible predictors of death, and then multivariate analysis was carried out to control for potential confounders. Results: An increase in the eosinophil count on the seventh day of hospitalisation was associated with a better prognosis, including lower mortality rates (5.2% vs. 22.6% in non-recoverers, OR 0.234; 95% CI, 0.154 to 0.354) and lower complication rates, especially regarding the development of acute respiratory distress syndrome (8% vs. 20.1%, p = 0.000) and ICU admission (5.4% vs. 10.8%, p = 0.000). Lymphocyte recovery was found to have no effect on prognosis. Treatment with inhaled or systemic glucocorticoids was not found to be a confounding factor. Conclusion: Eosinophil recovery in patients with COVID-19 who required hospitalisation had an independent prognostic value for all-cause mortality and a milder course. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
8. Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study.
- Author
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Artero A, Madrazo M, Fernández-Garcés M, Muiño Miguez A, González García A, Crestelo Vieitez A, García Guijarro E, Fonseca Aizpuru EM, García Gómez M, Areses Manrique M, Martinez Cilleros C, Fidalgo Moreno MDP, Loureiro Amigo J, Gil Sánchez R, Rabadán Pejenaute E, Abella Vázquez L, Cañizares Navarro R, Solís Marquínez MN, Carrasco Sánchez FJ, González Moraleja J, Montero Rivas L, Escobar Sevilla J, Martín Escalante MD, Gómez-Huelgas R, and Ramos-Rincón JM
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- Aged, Cohort Studies, Female, Hospital Mortality, Humans, Intensive Care Units, Male, Organ Dysfunction Scores, Prognosis, Retrospective Studies, SARS-CoV-2, Severity of Illness Index, COVID-19, Communicable Diseases, Community-Acquired Infections diagnosis, Community-Acquired Infections epidemiology, Pneumonia diagnosis, Pneumonia epidemiology
- Abstract
Background: Identification of patients on admission to hospital with coronavirus infectious disease 2019 (COVID-19) pneumonia who can develop poor outcomes has not yet been comprehensively assessed., Objective: To compare severity scores used for community-acquired pneumonia to identify high-risk patients with COVID-19 pneumonia., Design: PSI, CURB-65, qSOFA, and MuLBSTA, a new score for viral pneumonia, were calculated on admission to hospital to identify high-risk patients for in-hospital mortality, admission to an intensive care unit (ICU), or use of mechanical ventilation. Area under receiver operating characteristics curve (AUROC), sensitivity, and specificity for each score were determined and AUROC was compared among them., Participants: Patients with COVID-19 pneumonia included in the SEMI-COVID-19 Network., Key Results: We examined 10,238 patients with COVID-19. Mean age of patients was 66.6 years and 57.9% were males. The most common comorbidities were as follows: hypertension (49.2%), diabetes (18.8%), and chronic obstructive pulmonary disease (12.8%). Acute respiratory distress syndrome (34.7%) and acute kidney injury (13.9%) were the most common complications. In-hospital mortality was 20.9%. PSI and CURB-65 showed the highest AUROC (0.835 and 0.825, respectively). qSOFA and MuLBSTA had a lower AUROC (0.728 and 0.715, respectively). qSOFA was the most specific score (specificity 95.7%) albeit its sensitivity was only 26.2%. PSI had the highest sensitivity (84.1%) and a specificity of 72.2%., Conclusions: PSI and CURB-65, specific severity scores for pneumonia, were better than qSOFA and MuLBSTA at predicting mortality in patients with COVID-19 pneumonia. Additionally, qSOFA, the simplest score to perform, was the most specific albeit the least sensitive.
- Published
- 2021
- Full Text
- View/download PDF
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