180 results on '"Crickx, Etienne"'
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2. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials
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Hermine, Olivier, Mariette, Xavier, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Resche-Rigon, Matthieu, Tharaux, Pierre-Louis, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Porcher, Raphaël, Pourchet-Martinez, Valerie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Raked, Nabil, Mameri, Lakhdar, Montlahuc, Claire, Biard, Lucie, Alary, St.phanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Charreteur, Robin, Dupre, Céline, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Pavy, Stephan, Nocturne, Gaétane, Bitoun, Samuel, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stephane, Baudry, Elodie, Verny, Christiane, Lefevre, Edouard, Zaidan, Mohamad, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Grimaldi, Lamiae, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Soléne, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Le Tiec, Clotilde, Verstuyft, Céline, Roques, Anne-Marie, Georgin-Lavialle, Sophie, Senet, Patricia, Pialoux, Gilles, Soria, Angele, Parrot, Antoine, François, Helene, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadege, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, 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Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Héléne, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Chan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Marquis, Eric, Benoit, Philippe, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Helene, Mourad, Jean-Jacques, Sacco, Emmanuelle, Renet, Sophie, Ader, F., Yazdanpanah, Y., Mentre, F., Peiffer-Smadja, N., Lescure, F.X., Poissy, J., Bouadma, L., Timsit, J.F., Lina, B., Morfin-Sherpa, F., Bouscambert, M., Gaymard, A., Peytavin, G., Abel, L., Guedj, J., Andrejak, C., Burdet, C., Laouenan, C., Belhadi, D., Dupont, A., Alfaiate, T., Basli, B., Chair, A., Laribi, S., Level, J., Schneider, M., Tellier, M.C., Dechanet, A., Costagliola, D., Terrier, B., Ohana, M., Couffin-Cadiergues, S., Esperou, H., Delmas, C., Saillard, J., Fougerou, C., Moinot, L., Wittkop, L., Cagnot, C., Le Mestre, S., Lebrasseur-Longuet, D., Petrov-Sanchez, V., Diallo, A., Mercier, N., Icard, V., Leveau, B., Tubiana, S., Hamze, B., Gelley, A., Noret, M., D’Ortenzio, E., Puechal, O., Semaille, C., Welte, T., Paiva, J.A., Halanova, M., Kieny, M.P., Balssa, E., Birkle, C., Gibowski, S., Landry, E., Le Goff, A., Moachon, L., Moins, C., Wadouachi, L., Paul, C., Levier, A., Bougon, D., Djossou, F., Epelboin, L., Dellamonica, J., Marquette, C.H., Robert, C., Gibot, S., Senneville, E., Jean-Michel, V., Zerbib, Y., Chirouze, C., Boyer, A., Cazanave, C., Gruson, D., Malvy, D., Andreu, P., Quenot, J.P., Terzi, N., Faure, K., Chabartier, C., Le Moing, V., Klouche, K., Ferry, T., F, Valour, Gaborit, B., Canet, E., Le Turnier, P., Boutoille, D., Bani-Sadr, F., Benezit, F., Revest, M., Cameli, C., Caro, A., Um Tegue, MJ Ngo, Le Tulzo, Y., Laviolle, B., Laine, F., Thiery, G., Meziani, F., Hansmann, Y., Oulehri, W., Tacquard, C., Vardon-Bounes, F., Riu-Poulenc, B., Murris-Espin, M., Bernard, L., Garot, D., Hinschberger, O., Martinot, M., Bruel, C., Pilmis, B., Bouchaud, O., Loubet, P., Roger, C., Monnet, X., Figueiredo, S., Godard, V., Mira, J.P., Lachatre, M., Kerneis, S., Aboab, J., Sayre, N., Crockett, F., Lebeaux, D., Buffet, A., Diehl, J.L., Fayol, A., Hulot, J.S., Livrozet, M., Dessap, A Mekontso, Ficko, C., Stefan, F., Le Pavec, J., Mayaux, J., Ait-Oufella, H., Molina, J.M., Pialoux, G., Fartoukh, M., Textoris, J., Brossard, M., Essat, A., Netzer, E., Riault, Y., Ghislain, M., Beniguel, L., Genin, M., Gouichiche, L., Betard, C., Belkhir, L., Altdorfer, A., Centro, V Fraipont, Braz, S., Ribeiro, JM Ferreira, Alburqueque, R Roncon, Berna, M., Alexandre, M., Lamprecht, B., Egle, A., Greil, R., Joannidis, M., Patterson, Thomas F., Ponce, Philip O., Taylor, Barbara S., Patterson, Jan E., Bowling, Jason E., Javeri, Heta, Kalil, Andre C., Larson, LuAnn, Hewlett, Angela, Mehta, Aneesh K., Rouphael, Nadine G., Saklawi, Youssef, Scanlon, Nicholas, Traenkner, Jessica J., Trible, Ronald P., Jr., Walter, Emmanuel B., Ivey, Noel, Holland, Thomas L., Ruiz-Palacios, Guillermo M., Ponce de León, Alfredo, Rajme, Sandra, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Lee, Helen S., Kline, Susan, Billings, Joanne, Noren, Brooke, Kim, Hyun, Bold, Tyler D., Tapson, Victor, Grein, Jonathan, Sutterwala, Fayyaz, Iovine, Nicole, Beattie, Lars K., Wakeman, Rebecca Murray, Shaw, Matthew, Jain, Mamta K., Mocherla, Satish, Meisner, Jessica, Luque, Amneris, Sweeney, Daniel A., Benson, Constance A., Ali, Farhana, Atmar, Robert L., El Sahly, Hana M., Whitaker, Jennifer, Falsey, Ann R., Branche, Angela R., Rozario, Cheryl, Pineda, Justino Regalado, Martinez-Orozco, José Arturo, Lye, David Chien, Ong, Sean WX., Chia, Po Ying, Young, Barnaby E., Sandkovsky, Uriel, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Cantos, Valeria D., Kelley, Colleen F., Rebolledo Esteinou, Paulina A., Kandiah, Sheetal, Doernberg, Sarah B., Crouch, Pierre-Cedric B., Jang, Hannah, Luetkemeyer, Anne F., Dwyer, Jay, Cohen, Stuart H., Thompson, George R., 3rd, Nguyen, Hien H., Finberg, Robert W., Wang, Jennifer P., Perez-Velazquez, Juan, Wessolossky, Mireya, Jackson, Patrick E.H., Bell, Taison D., West, Miranda J., Taiwo, Babafemi, Krueger, Karen, Perez, Johnny, Pearson, Triniece, Paules, Catharine I., Julian, Kathleen G., Ahmad, Danish, Hajduczok, Alexander G., Arguinchona, Henry, Arguinchona, Christa, Erdmann, Nathaniel, Goepfert, Paul, Ahuja, Neera, Frank, Maria G., Wyles, David, Young, Heather, Oh, Myoung-don, Park, Wan Beom, Kang, Chang Kyung, Marconi, Vincent, Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Kim, Eu Suk, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Tan, Seow Yen, Shafi, Humaira, Chien, Jaime, Fong, Raymond KC., Murray, Daniel D., Lundgren, Jens, Nielsen, Henrik, Jensen, Tomas, Zingman, Barry S., Grossberg, Robert, Riska, Paul F., Yang, Otto O., Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R., Hauser, Naomi, Campbell, James D., Short, William R., Tebas, Pablo, Baron, Jillian T., McLellan, Susan L.F., Blanton, Lucas S., Seashore, Justin B., Creech, C. Buddy, Rice, Todd W., Walker, Shannon, Thomsen, Isaac P., Lopez de Castilla, Diego, Van Winkle, Jason W., Riedo, Francis X., Pada, Surinder Kaur, Wang, Alvin DY., Lin, Li, Harkins, Michelle, Mertz, Gregory, Sosa, Nestor, Ann Chai, Louis Yi, Tambyah, Paul Anantharajah, Tham, Sai Meng, Archuleta, Sophia, Yan, Gabriel, Lindholm, David A., Markelz, Ana Elizabeth, Mende, Katrin, Mularski, Richard, Hohmann, Elizabeth, Torres-Soto, Mariam, Jilg, Nikolaus, Maves, Ryan C., Utz, Gregory C., George, Sarah L., Hoft, Daniel F., Brien, James D., Paredes, Roger, Mateu, Lourdes, Loste, Cora, Kumar, Princy, Thornton, Sarah, Mohanraj, Sharmila, Hynes, Noreen A., Sauer, Lauren M., Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Chambers, Susan E., Novak, Richard M., Wendrow, Andrea, Gupta, Samir K., Lee, Tida, Lalani, Tahaniyat, Holodniy, Mark, Chary, Aarthi, Huprikar, Nikhil, Ganesan, Anuradha, Ohmagari, Norio, Mikami, Ayako, Price, D. Ashley, Duncan, Christopher J.A., Dierberg, Kerry, Neumann, Henry J., Taylor, Stephanie N., Lacour, Alisha, Masri, Najy, Swiatlo, Edwin, Widmer, Kyle, Neaton, James D., Bessesen, Mary, Stephens, David S., Burgess, Timothy H., Uyeki, Timothy M., Walker, Robert, Marks, G. Lynn, Osinusi, Anu, Cao, Huyen, Cardoso, Anabela, de Bono, Stephanie, Schlichting, Douglas E., Chung, Kevin K., Ferreira, Jennifer L., Green, Michelle, Makowski, Mat, Wierzbicki, Michael R., Conrad, Tom M., El-Khorazaty, Jill Ann, Hill, Heather, Bonnett, Tyler, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Beigel, John H., Tomashek, Kay M., Ghazaryan, Varduhi, Beresnev, Tatiana, Nayak, Seema, Dodd, Lori E., Dempsey, Walla, Nomicos, Effie, Lee, Marina, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Voell, Jocelyn D., Davey, Richard, Serrano, Ruth C., Wiley, Zanthia, Phadke, Varun K., Goepfert, Paul A., Gomez, Carlos A., Sofarelli, Theresa A., Certain, Laura, Imlay, Hannah N., Wolfe, Cameron R., Ko, Emily R., Engemann, John J., Felix, Nora Bautista, Wan, Claire R., Elmor, Sammy T., Bristow, Laurel R., Harkins, Michelle S., Iovine, Nicole M., Elie-Turenne, Marie-Carmelle, Tapson, Victor F., Choe, Pyoeng Gyun, Mularski, Richard A., Rhie, Kevin S., Hussein, Rezhan H., Ince, Dilek, Winokur, Patricia L., Takasaki, Jin, Saito, Sho, McConnell, Kimberly, Wyles, David L., Sarcone, Ellen, Grimes, Kevin A., Perez, Katherine, Janak, Charles, Whitaker, Jennifer A., Rebolledo, Paulina A., Gharbin, John, Lambert, Allison A., Zea, Diego F., Bainbridge, Emma, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Ling, Evelyn, Go, Minjoung, Hubbard, Fleesie A., Chakrabarty, Melony, Laguio-Vila, Maryrose, Walsh, Edward E., Guirgis, Faheem, Marconi, Vincent C., Madar, Christian, Borgetti, Scott A., Levine, Corri, Nock, Joy, Candiotti, Keith, Rozman, Julia, Dangond, Fernando, Hyvert, Yann, Seitzinger, Andrea, Cross, Kaitlyn, Pettibone, Stephanie, Nayak, Seema U., Deye, Gregory A., Siempos, Ilias I., Belhadi, Drifa, Veiga, Viviane Cordeiro, Cavalcanti, Alexandre Biasi, Branch-Elliman, Westyn, Papoutsi, Eleni, Gkirgkiris, Konstantinos, Xixi, Nikoleta A., and Kotanidou, Anastasia
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- 2024
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3. JAK inhibitor treatment for inborn errors of JAK/STAT signaling: An ESID/EBMT-IEWP retrospective study
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Fischer, Marco, Olbrich, Peter, Hadjadj, Jérôme, Aumann, Volker, Bakhtiar, Shahrzad, Barlogis, Vincent, von Bismarck, Philipp, Bloomfield, Markéta, Booth, Claire, Buddingh, Emmeline P., Cagdas, Deniz, Castelle, Martin, Chan, Alice Y., Chandrakasan, Shanmuganathan, Chetty, Kritika, Cougoul, Pierre, Crickx, Etienne, Dara, Jasmeen, Deyà-Martínez, Angela, Farmand, Susan, Formankova, Renata, Gennery, Andrew R., Gonzalez-Granado, Luis Ignacio, Hagin, David, Hanitsch, Leif Gunnar, Hanzlikovà, Jana, Hauck, Fabian, Ivorra-Cortés, José, Kisand, Kai, Kiykim, Ayca, Körholz, Julia, Leahy, Timothy Ronan, van Montfrans, Joris, Nademi, Zohreh, Nelken, Brigitte, Parikh, Suhag, Plado, Silvi, Ramakers, Jan, Redlich, Antje, Rieux-Laucat, Frédéric, Rivière, Jacques G., Rodina, Yulia, Júnior, Pérsio Roxo, Salou, Sarah, Schuetz, Catharina, Shcherbina, Anna, Slatter, Mary A., Touzot, Fabien, Unal, Ekrem, Lankester, Arjan C., Burns, Siobhan, Seppänen, Mikko R.J., Neth, Olaf, Albert, Michael H., Ehl, Stephan, Neven, Bénédicte, and Speckmann, Carsten
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- 2024
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4. SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals
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Sokal, Aurélien, Barba-Spaeth, Giovanna, Hunault, Lise, Fernández, Ignacio, Broketa, Matteo, Meola, Annalisa, Fourati, Slim, Azzaoui, Imane, Vandenberghe, Alexis, Lagouge-Roussey, Pauline, Broutin, Manon, Roeser, Anais, Bouvier-Alias, Magali, Crickx, Etienne, Languille, Laetitia, Fournier, Morgane, Michel, Marc, Godeau, Bertrand, Gallien, Sébastien, Melica, Giovanna, Nguyen, Yann, Canoui-Poitrine, Florence, Pirenne, France, Megret, Jérôme, Pawlotsky, Jean-Michel, Fillatreau, Simon, Reynaud, Claude-Agnès, Weill, Jean-Claude, Rey, Félix A., Bruhns, Pierre, Mahévas, Matthieu, and Chappert, Pascal
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- 2023
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5. Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
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Guillet, Stéphanie, Crickx, Etienne, Azzaoui, Imane, Chappert, Pascal, Boutin, Emmanuelle, Viallard, Jean-François, Rivière, Etienne, Gobert, Delphine, Galicier, Lionel, Malphettes, Marion, Cheze, Stéphane, Lefrere, François, Audia, Sylvain, Bonnotte, Bernard, Lambotte, Olivier, Noel, Nicolas, Fain, Olivier, Moulis, Guillaume, Hamidou, Mohamed, Gerfaud-Valentin, Mathieu, Marolleau, Jean-Pierre, Terriou, Louis, Martis, Nihal, Morin, Anne-Sophie, Perlat, Antoinette, Le Gallou, Thomas, Roy-Peaud, Frédérique, Robbins, Ailsa, Lega, Jean-Christophe, Puyade, Matthieu, Comont, Thibault, Limal, Nicolas, Languille, Laetitia, Zarrour, Anissa, Luka, Marine, Menager, Mickael, Belmondo, Thibault, Hue, Sophie, Canoui-Poitrine, Florence, Michel, Marc, Godeau, Bertrand, and Mahévas, Matthieu
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- 2023
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6. Clinical picture, outcomes and predictors of relapse in eosinophilia-associated coronary vasospasm: data from a European multicentric study
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Huang, Florent, primary, Khellaf, Lucas Rémi, additional, Lefèvre, Guillaume, additional, Berti, Alvise, additional, d’Humières, Thomas, additional, Sionis, Alessandro, additional, Ariza Solé, Albert, additional, Bello, Federica, additional, Bermeo Garrido, Juan Andres, additional, Crickx, Etienne, additional, Delvino, Paolo, additional, Emmi, Giacomo, additional, Gaillet, Antoine, additional, Garcia, Gilles, additional, Gavand, Pierre-Edouard, additional, George, Jean-Louis, additional, Gilles, Floriane, additional, Golden, Cécile, additional, de Groote, Pascal, additional, Guffroy, Aurélien, additional, Martis, Nihal, additional, Monti, Sara, additional, Mourlanette, Pierre, additional, Pineton de Chambrun, Marc, additional, Prunier, Fabrice, additional, Regola, Francesca, additional, Seret, Gabriel, additional, Terrier, Benjamin, additional, Tréfond, Ludovic, additional, Souteyrand, Géraud, additional, Varenne, Olivier, additional, Zilio, Filippo, additional, Haziza, Franck, additional, Benamer, Hakim, additional, Kahn, Jean-Emmanuel, additional, Vallée, Alexandre, additional, and Groh, Matthieu, additional
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- 2024
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7. Pericardial Abscess in an Immunocompromised Patient
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Larue, Marion, primary, Danjean, Maxime, additional, Lepeule, Raphaël, additional, Woerther, Paul-Louis, additional, and Crickx, Etienne, additional
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- 2024
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8. Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen : observational comparative study using routine care data
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Mahévas, Matthieu, Tran, Viet-Thi, Roumier, Mathilde, Chabrol, Amélie, Paule, Romain, Guillaud, Constance, Fois, Elena, Lepeule, Raphael, Szwebel, Tali-Anne, Lescure, François-Xavier, Schlemmer, Frédéric, Matignon, Marie, Khellaf, Mehdi, Crickx, Etienne, Terrier, Benjamin, Morbieu, Caroline, Legendre, Paul, Dang, Julien, Schoindre, Yoland, Pawlotsky, Jean-Michel, Michel, Marc, Perrodeau, Elodie, Carlier, Nicolas, Roche, Nicolas, de Lastours, Victoire, Ourghanlian, Clément, Kerneis, Solen, Ménager, Philippe, Mouthon, Luc, Audureau, Etienne, Ravaud, Philippe, Godeau, Bertrand, Gallien, Sébastien, and Costedoat-Chalumeau, Nathalie
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- 2020
9. Anti-CD20–mediated B-cell depletion in autoimmune diseases: successes, failures and future perspectives
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Crickx, Etienne, Weill, Jean-Claude, Reynaud, Claude-Agnès, and Mahévas, Matthieu
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- 2020
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10. JAK inhibitor treatment for inborn errors of JAK/STAT signaling: An ESID/EBMT-IEWP retrospective study
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Fischer, Marco, primary, Olbrich, Peter, additional, Hadjadj, Jérôme, additional, Aumann, Volker, additional, Bakhtiar, Shahrzad, additional, Barlogis, Vincent, additional, von Bismarck, Philipp, additional, Bloomfield, Markéta, additional, Booth, Claire, additional, Buddingh, Emmeline P., additional, Cagdas, Deniz, additional, Castelle, Martin, additional, Chan, Alice Y., additional, Chandrakasan, Shanmuganathan, additional, Chetty, Kritika, additional, Cougoul, Pierre, additional, Crickx, Etienne, additional, Dara, Jasmeen, additional, Deyà-Martínez, Angela, additional, Farmand, Susan, additional, Formankova, Renata, additional, Gennery, Andrew R., additional, Gonzalez-Granado, Luis Ignacio, additional, Hagin, David, additional, Hanitsch, Leif Gunnar, additional, Hanzlikovà, Jana, additional, Hauck, Fabian, additional, Ivorra-Cortés, José, additional, Kisand, Kai, additional, Kiykim, Ayca, additional, Körholz, Julia, additional, Leahy, Timothy Ronan, additional, van Montfrans, Joris, additional, Nademi, Zohreh, additional, Nelken, Brigitte, additional, Parikh, Suhag, additional, Plado, Silvi, additional, Ramakers, Jan, additional, Redlich, Antje, additional, Rieux-Laucat, Frédéric, additional, Rivière, Jacques G., additional, Rodina, Yulia, additional, Júnior, Pérsio Roxo, additional, Salou, Sarah, additional, Schuetz, Catharina, additional, Shcherbina, Anna, additional, Slatter, Mary A., additional, Touzot, Fabien, additional, Unal, Ekrem, additional, Lankester, Arjan C., additional, Burns, Siobhan, additional, Seppänen, Mikko R.J., additional, Neth, Olaf, additional, Albert, Michael H., additional, Ehl, Stephan, additional, Neven, Bénédicte, additional, and Speckmann, Carsten, additional
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- 2023
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11. High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura
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Canales-Herrerias, Pablo, Crickx, Etienne, Broketa, Matteo, Sokal, Aurelien, Chenon, Guilhem, Azzaoui, Imane, Vandenberghe, Alexis, Perima, Angga, Iannascoli, Bruno, Goff, Odile Richard-Le, Castrillon, Carlos, Motte, Guillaume, Sterlin, Delphine, Robbins, Ailsa, Michel, Marc, England, Patrick, Eyer, Klaus, Millo, Gael A., Baudry, Jean, Mahevas, Matthieu, and Bruhns, Pierre
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Autoimmunity -- Health aspects ,Plasma cells -- Health aspects ,Thrombocytopenic purpura -- Complications and side effects -- Drug therapy ,Health care industry - Abstract
The major therapeutic goal for immune thrombocytopenic purpura (ITP) is to restore normal platelet counts using drugs to promote platelet production or by interfering with mechanisms responsible for platelet destruction. Eighty percent of patients with ITP possess anti-integrin [alpha]IIb[beta]3 IgG autoantibodies that cause platelet opsonization and phagocytosis. The spleen is considered the primary site of autoantibody production by autoreactive B cells and platelet destruction. The immediate failure in approximately 50% of patients to recover a normal platelet count after anti-CD20 rituximab-mediated B cell depletion and splenectomy suggests that autoreactive, rituximab-resistant, IgG-secreting B cells (IgG-SCs) reside in other anatomical compartments. We analyzed more than 3,300 single IgG-SCs from spleen, bone marrow, and/or blood of 27 patients with ITP, revealing high interindividual variability in affinity for [alpha]IIb[beta]3, with variations over 3 logs. IgG-SC dissemination and range of affinities were, however, similar for each patient. Longitudinal analysis of autoreactive IgG-SCs upon treatment with the anti-CD38 mAb daratumumab demonstrated variable outcomes, from complete remission to failure with persistence of high-affinity anti-[alpha]IIb[beta]3 IgG-SCs in the bone marrow. This study demonstrates the existence and dissemination of high-affinity autoreactive plasma cells in multiple anatomical compartments of patients with ITP that may cause the failure of current therapies., Introduction Immune thrombocytopenic purpura (ITP) is an immune disorder characterized by a strong autoimmune response against platelet autoantigens that causes platelet destruction (1). Clinical manifestations often present as mild bleeding [...]
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- 2022
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12. BAFF and CD4+ T cells are major survival factors for long-lived splenic plasma cells in a B-cell–depletion context
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Thai, Lan-Huong, Le Gallou, Simon, Robbins, Ailsa, Crickx, Etienne, Fadeev, Tatiana, Zhou, Zhicheng, Cagnard, Nicolas, Mégret, Jérôme, Bole, Christine, Weill, Jean-Claude, Reynaud, Claude-Agnès, and Mahévas, Matthieu
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- 2018
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13. Combining thrombopoietin receptor agonists with immunosuppressive drugs in adult patients with multirefractory immune thrombocytopenia, an update on the French experience
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Crickx, Etienne, primary, Ebbo, Mikael, additional, Rivière, Etienne, additional, Souchaud‐Debouverie, Odile, additional, Terriou, Louis, additional, Audia, Sylvain, additional, Ruivard, Marc, additional, Asli, Bouchra, additional, Marolleau, Jean‐Pierre, additional, Méaux‐Ruault, Nadine, additional, Gerfaud‐Valentin, Mathieu, additional, Audeguy, Philippe, additional, Hamidou, Mohamed, additional, Corm, Selim, additional, Delbrel, Xavier, additional, Fontan, Jean, additional, Lebon, Delphine, additional, Mausservey, Christelle, additional, Moulis, Guillaume, additional, Limal, Nicolas, additional, Michel, Marc, additional, Godeau, Bertrand, additional, and Mahévas, Matthieu, additional
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- 2023
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14. Single-cell RNA-sequencing of PBMCs from SAVI patients reveals disease-associated monocytes with elevated integrated stress response
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de Cevins, Camille, primary, Delage, Laure, additional, Batignes, Maxime, additional, Riller, Quentin, additional, Luka, Marine, additional, Remaury, Anne, additional, Sorin, Boris, additional, Fali, Tinhinane, additional, Masson, Cecile, additional, Hoareau, Benedicte, additional, Meunier, Catherine, additional, Parisot, Melanie, additional, Zarhrate, Mohammed, additional, Perot, Brieuc Pierre, additional, Garcia, Victor, additional, Carbone, Francesco, additional, Canard, Luc, additional, Boussard, Charlotte, additional, Crickx, Etienne, additional, Guillemot, Jean-Claude, additional, Fremont, Marie-Louise, additional, Neven, Benedicte, additional, Boldina, Galina, additional, Auge, Franck, additional, Fischer, Alain, additional, Dider, Michel, additional, Rieux-Laucat, Frederic, additional, and Menager, Mickael Mathieu, additional
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- 2023
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15. Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome
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Leiding, Jennifer W., primary, Vogel, Tiphanie P., additional, Santarlas, Valentine G.J., additional, Mhaskar, Rahul, additional, Smith, Madison R., additional, Carisey, Alexandre, additional, Vargas-Hernández, Alexander, additional, Silva-Carmona, Manuel, additional, Heeg, Maximilian, additional, Rensing-Ehl, Anne, additional, Neven, Bénédicte, additional, Hadjadj, Jérôme, additional, Hambleton, Sophie, additional, Ronan Leahy, Timothy, additional, Meesilpavikai, Kornvalee, additional, Cunningham-Rundles, Charlotte, additional, Dutmer, Cullen M., additional, Sharapova, Svetlana O., additional, Taskinen, Mervi, additional, Chua, Ignatius, additional, Hague, Rosie, additional, Klemann, Christian, additional, Kostyuchenko, Larysa, additional, Morio, Tomohiro, additional, Thatayatikom, Akaluck, additional, Ozen, Ahmet, additional, Scherbina, Anna, additional, Bauer, Cindy S., additional, Flanagan, Sarah E., additional, Gambineri, Eleonora, additional, Giovannini-Chami, Lisa, additional, Heimall, Jennifer, additional, Sullivan, Kathleen E., additional, Allenspach, Eric, additional, Romberg, Neil, additional, Deane, Sean G., additional, Prince, Benjamin T., additional, Rose, Melissa J., additional, Bohnsack, John, additional, Mousallem, Talal, additional, Jesudas, Rohith, additional, Santos Vilela, Maria Marluce Dos, additional, O’Sullivan, Michael, additional, Pachlopnik Schmid, Jana, additional, Průhová, Štěpánka, additional, Klocperk, Adam, additional, Rees, Matthew, additional, Su, Helen, additional, Bahna, Sami, additional, Baris, Safa, additional, Bartnikas, Lisa M., additional, Chang Berger, Amy, additional, Briggs, Tracy A., additional, Brothers, Shannon, additional, Bundy, Vanessa, additional, Chan, Alice Y., additional, Chandrakasan, Shanmuganathan, additional, Christiansen, Mette, additional, Cole, Theresa, additional, Cook, Matthew C., additional, Desai, Mukesh M., additional, Fischer, Ute, additional, Fulcher, David A., additional, Gallo, Silvanna, additional, Gauthier, Amelie, additional, Gennery, Andrew R., additional, Gonçalo Marques, José, additional, Gottrand, Frédéric, additional, Grimbacher, Bodo, additional, Grunebaum, Eyal, additional, Haapaniemi, Emma, additional, Hämäläinen, Sari, additional, Heiskanen, Kaarina, additional, Heiskanen-Kosma, Tarja, additional, Hoffman, Hal M., additional, Gonzalez-Granado, Luis Ignacio, additional, Guerrerio, Anthony L., additional, Kainulainen, Leena, additional, Kumar, Ashish, additional, Lawrence, Monica G., additional, Levin, Carina, additional, Martelius, Timi, additional, Neth, Olaf, additional, Olbrich, Peter, additional, Palma, Alejandro, additional, Patel, Niraj C., additional, Pozos, Tamara, additional, Preece, Kahn, additional, Lugo Reyes, Saúl Oswaldo, additional, Russell, Mark A., additional, Schejter, Yael, additional, Seroogy, Christine, additional, Sinclair, Jan, additional, Skevofilax, Effie, additional, Suan, Daniel, additional, Suez, Daniel, additional, Szabolcs, Paul, additional, Velasco, Helena, additional, Warnatz, Klaus, additional, Walkovich, Kelly, additional, Worth, Austen, additional, Seppänen, Mikko R.J., additional, Torgerson, Troy R., additional, Sogkas, Georgios, additional, Ehl, Stephan, additional, Tangye, Stuart G., additional, Cooper, Megan A., additional, Milner, Joshua D., additional, Forbes Satter, Lisa R., additional, Aleshkevich, Svetlana, additional, Allende, Luis M., additional, Atkinson, T. Prescott, additional, Atschekzei, Faranaz, additional, Aydemir, Sezin, additional, Aygunes, Utku, additional, Barlogis, Vincent, additional, Baumann, Ulrich, additional, Belko, John, additional, Bezrodnik, Liliana, additional, Biebl, Ariane, additional, Broderick, Lori, additional, Bunin, Nancy J., additional, Caldirola, Maria Soledad, additional, Castelle, Martin, additional, Celmeli, Fatih, additional, Charbonnier, Louis-Marie, additional, Chatila, Talal A., additional, Chellapandian, Deepak, additional, Cokugras, Haluk, additional, Conlon, Niall, additional, Cox, Fionnuala, additional, Crickx, Etienne, additional, Dalgic, Buket, additional, ASH Dalm, Virgil, additional, Danielian, Silvia, additional, Dominguez-Pinilla, Nerea, additional, Dujovny, Tal, additional, Ebbo, Mikael, additional, Eken, Ahmet, additional, Esty, Brittany, additional, Fabre, Alexandre, additional, Fischer, Alain, additional, Hannibal, Mark, additional, Huppert, Laura, additional, Ikeda, Marc D., additional, Jolles, Stephen, additional, Jolly, Kent W., additional, Jones, Neil, additional, Kanariou, Maria, additional, Karakoc-Aydiner, Elif, additional, Karamantziani, Theoni, additional, Kelaidi, Charikleia, additional, Keogan, Mary, additional, Pac Kisaarslan, Ayşenur, additional, Kiykim, Ayca, additional, Kotsonis, Kosmas, additional, Kuzmenko, Natalia, additional, Leroy, Sylvie, additional, Lianou, Dimitra, additional, Longhurst, Hilary, additional, Lorenz, Myriam Ricarda, additional, Maffucci, Patrick, additional, Manson, Ania, additional, Marchal, Sarah, additional, Malphettes, Marion, additional, Marega, Lia Furlaneto, additional, Mauracher, Andrea A., additional, Miller, Holly, additional, Mombourquette, Joy, additional, Morgan, Noel G., additional, Mukhina, Anna, additional, Nathalie, Aladjidi, additional, Nelken, Brigitte, additional, Nolan, David, additional, Norlin, Anna-Carin, additional, Oleastro, Matias, additional, Ozcan, Alper, additional, Pasquet, Marlene, additional, Pegler, José Roberto, additional, Picard, Capucine, additional, Polychronopoulou, Sophia, additional, Quartier, Pierre, additional, Quesada, Juan Francisco, additional, Ramakers, Jan, additional, Randall, Katrina L., additional, Rao, V. Koneti, additional, Remiker, Allison, additional, Resin, Geraldine, additional, Richmond, Peter, additional, Rieux-Laucat, Frederic, additional, Rodina, Yulia, additional, Rohrlich, Pierre, additional, Sachs, Johnathan, additional, Sakovich, Inga, additional, Santarlas, Christopher, additional, Sari, Sinan, additional, Sawicki, Gregory, additional, Schauer, Uwe, additional, Scheffler Mendoza, Selma C., additional, Schvetz, Oksana, additional, Schmidt, Reinhold Ernst, additional, Schwarz, Klaus, additional, Sediva, Anna, additional, Sinclair, Kyle, additional, Slatter, Mary, additional, Sleasman, John, additional, Stergiou, Katerina, additional, Suratannon, Narissara, additional, Tanita, Kay, additional, Thompson, Grace, additional, Travis, Stephen, additional, Trojan, Timothy, additional, Tsinti, Maria, additional, Unal, Ekrem, additional, Urdinez, Luciano, additional, Vazquez-Gomez, Felisa, additional, Villa, Mariana, additional, Weinrich, Michael, additional, Weiss, Mitchell J., additional, Wright, Benjamin, additional, Yilmaz, Ebru, additional, Zachova, Radana, additional, and Zhang, Yu, additional
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- 2023
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16. COVID‐19 and splenectomy: Education matters
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Crickx, Etienne, primary
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- 2023
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17. Omicron BA.1 breakthrough infection drives long-term remodeling of the memory B cell repertoire in vaccinated individuals
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Sokal, Aurélien, primary, Barba-Spaeth, Giovanna, additional, Hunault, Lise, additional, Fernández, Ignacio, additional, Broketa, Matteo, additional, Meola, Annalisa, additional, Fourati, Slim, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Lagouge-Roussey, Pauline, additional, Broutin, Manon, additional, Roeser, Anais, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Languille, Laetitia, additional, Fournier, Morgane, additional, Michel, Marc, additional, Godeau, Bertrand, additional, Gallien, Sébastien, additional, Melica, Giovanna, additional, Nguyen, Yann, additional, Canoui-Poitrine, Florence, additional, Noizat-Pirenne, France, additional, Megret, Jérôme, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Reynaud, Claude-Agnès, additional, Weill, Jean-Claude, additional, Rey, Félix A., additional, Bruhns, Pierre, additional, Mahévas, Matthieu, additional, and Chappert, Pascal, additional
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- 2023
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18. Older Adults and Immune Thrombocytopenia: Considerations for the Clinician
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Crickx, Etienne, primary, Mahévas, Matthieu, additional, Michel, Marc, additional, and Godeau, Bertrand, additional
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- 2023
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19. Omicron BA.1 breakthrough infection drives long-term remodeling of the memory B cell repertoire in vaccinated individuals
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Sokal, Aurélien, Barba-Spaeth, Giovanna, Hunault, Lise, Fernández, Ignacio, Broketa, Matteo, Meola, Annalisa, Fourati, Slim, Azzaoui, Imane, Vandenberghe, Alexis, Lagouge-Roussey, Pauline, Broutin, Manon, Roeser, Anais, Bouvier-Alias, Magali, Crickx, Etienne, Languille, Laetitia, Fournier, Morgane, Michel, Marc, Godeau, Bertrand, Gallien, Sébastien, Melica, Giovanna, Nguyen, Yann, Canoui-Poitrine, Florence, Noizat-Pirenne, France, Megret, Jérôme, Pawlotsky, Jean-Michel, Fillatreau, Simon, Reynaud, Claude-Agnès, Weill, Jean-Claude, Rey, Félix, Bruhns, Pierre, Mahévas, Matthieu, Chappert, Pascal, Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CIC - CHU Henri Mondor, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Virologie Structurale - Structural Virology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Physiologie, physiopathologie et thérapeutique (ED 394), Sorbonne Université (SU), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Henri Mondor [Créteil], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Cochin [AP-HP], IMRB - CEPIA/'Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Etablissement Français du Sang [Créteil], Structure Fédérative de Recherche Necker (SFR Necker - UMS 3633 / US24), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and This work was funded by the CAPNET (Comité ad-hoc de pilotage national des essaisthérapeutiques et autres recherches, French government) and by the Fondation PrincesseGrace. Assistance Publique – Hôpitaux de Paris (AP-HP, Département de la Recherche Cli-nique et du Développement) was the promotor and sponsor of MEMO-COV-2. Work in theUnit of Structural Virology was funded by Institut Pasteur, Urgence COVID-19 FundraisingCampaign of Institut Pasteur. PB acknowledges funding from the Institut Pasteur and InsitutNational de la Santé et de la Recherche Médicale (INSERM). AS was supported by a Posted’accueil from INSERM.
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[SDV]Life Sciences [q-bio] ,[SDV.IMM]Life Sciences [q-bio]/Immunology - Abstract
SummaryHow infection by a viral variant showing antigenic drift impacts a preformed mature human memory B cell (MBC) repertoire remains an open question. Here, we studied the MBC response up to 6 months after Omicron BA.1 breakthrough infection in individuals previously vaccinated with three doses of mRNA vaccine. Longitudinal analysis, using single-cell multi-omics and functional analysis of monoclonal antibodies from RBD-specific MBCs, revealed that a BA.1 breakthrough infection mostly recruited pre-existing cross-reactive MBCs with limitedde novoresponse against BA.1-restricted epitopes. Reorganization of clonal hierarchy and new rounds of germinal center reaction, however, combined to maintain diversity and induce progressive maturation of the MBC repertoire against common Hu-1 and BA.1, but not BA.5-restricted, SARS-CoV-2 Spike RBD epitopes. Such remodeling was further associated with marked improvement in overall neutralizing breadth and potency. These findings have fundamental implications for the design of future vaccination booster strategies.
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- 2023
20. Severe SARS‐CoV‐2 infection in rituximab‐treated patients with autoimmune cytopenia: A multicenter observational study.
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Sorin, Boris, Gaigne, Léa, Garzaro, Margaux, Moulis, Guillaume, Mageau, Arthur, Lopez, Carine, Roy‐Peaud, Frédérique, Jeandel, Pierre‐Yves, Crickx, Etienne, Dossier, Antoine, Gobert, Delphine, Hadjadj, Jérôme, Puyade, Mathieu, Languille, Laetitia, Rasmussen, Camille, Terrier, Benjamin, Ebbo, Mikael, Bonnotte, Bernard, Audia, Sylvain, and Galicier, Lionel
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- 2023
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21. La néoplasie myéloïde associée à un réarrangement de PDGFRB : une pathologie rare de diagnostic difficile
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Bontoux, Christophe, primary, Badaoui, Bouchra, additional, Abermil, Nassera, additional, Tarfi, Sihem, additional, Guermouche, Hélène, additional, Dubois, Sydney, additional, Roy, Lydia, additional, Xuan, Juliette Vo, additional, Quang, Violaine Tran, additional, Wang, Luojun, additional, Favre, Loetitia, additional, Poullot, Elsa, additional, Michel, Marc, additional, Sloma, Ivan, additional, Crickx, Etienne, additional, and Pécriaux, Adrien, additional
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- 2022
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22. Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting
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Chappert, Pascal, primary, Huetz, François, additional, Espinasse, Marie-Alix, additional, Chatonnet, Fabrice, additional, Pannetier, Louise, additional, Da Silva, Lucie, additional, Goetz, Clara, additional, Mégret, Jérome, additional, Sokal, Aurélien, additional, Crickx, Etienne, additional, Nemazanyy, Ivan, additional, Jung, Vincent, additional, Guerrera, Chiara, additional, Storck, Sébastien, additional, Mahévas, Matthieu, additional, Cosma, Antonio, additional, Revy, Patrick, additional, Fest, Thierry, additional, Reynaud, Claude-Agnès, additional, and Weill, Jean-Claude, additional
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- 2022
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23. A Mauritanian Woman With a Swollen Knee
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Crickx, Etienne, Buffet, Pierre, Caumes, Éric, and Jauréguiberry, Stéphane
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- 2013
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24. Analysis of mRNA vaccination-elicited RBD-specific memory B cells reveals strong but incomplete immune escape of the SARS-CoV-2 Omicron variant
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Sokal, Aurélien, primary, Broketa, Matteo, additional, Barba-Spaeth, Giovanna, additional, Meola, Annalisa, additional, Fernández, Ignacio, additional, Fourati, Slim, additional, Azzaoui, Imane, additional, de La Selle, Andrea, additional, Vandenberghe, Alexis, additional, Roeser, Anais, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Languille, Laetitia, additional, Michel, Marc, additional, Godeau, Bertrand, additional, Gallien, Sébastien, additional, Melica, Giovanna, additional, Nguyen, Yann, additional, Zarrouk, Virginie, additional, Canoui-Poitrine, Florence, additional, Noizat-Pirenne, France, additional, Megret, Jérôme, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Simon-Lorière, Etienne, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, Rey, Félix A., additional, Bruhns, Pierre, additional, Chappert, Pascal, additional, and Mahévas, Matthieu, additional
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- 2022
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25. De novo and relapsed immune thrombocytopenia after COVID-19 vaccines: results of French safety monitoring
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Moulis, Guillaume, Crickx, Etienne, Thomas, Laure, Massy, Nathalie, Mahévas, Matthieu, Valnet-Rabier, Marie-Blanche, Atzenhoffer, Marina, Michel, Marc, Godeau, Bertrand, Bagheri, Haleh, and Salvo, Francesco
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- 2022
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26. Dynamic Interactions Within the Splenic Niche and Long-Lasting Germinal Center Imprinting Define Human Anti-Vaccinia Long-Lived Memory B Cells
- Author
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Chappert, Pascal, primary, Huetz, François, additional, Espinasse, Marie-Alix, additional, Chatonnet, Fabrice, additional, Pannetier, Louise, additional, Da Silva, Lucie, additional, Goetz, Clara, additional, Megret, Jérôme, additional, Sokal, Aurélien, additional, Crickx, Etienne, additional, Nemazanyy, Ivan, additional, Jung, Vincent, additional, Guerrera, Chiara, additional, Storck, Sébastien, additional, Mahévas, Matthieu, additional, Cosma, Antonio, additional, Revy, Patrick, additional, Fest, Thierry, additional, Reynaud, Claude-Agnès, additional, and Weill, Jean-Claude, additional
- Published
- 2022
- Full Text
- View/download PDF
27. Immune escape of SARS-CoV-2 Omicron variant from mRNA vaccination-elicited RBD-specific memory B cells.
- Author
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Sokal, Aurelien, primary, Broketa, Matteo, additional, Meola, Annalisa, additional, Barba-Spaeth, Giovanna, additional, Fernandez, Ignacio, additional, Fourati, Slim, additional, Azzaoui, Imane, additional, de La Selle, Andrea, additional, Vandenberghe, Alexis, additional, Roeser, Anais, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Languille, Laetitia, additional, Michel, Marc, additional, Godeau, Bertrand, additional, Gallien, Sebastien, additional, Melica, Giovanna, additional, Nguyen, Yann, additional, Zarrouk, Virginie, additional, Canoui-Poitrine, Florence, additional, Noizat-Pirenne, France, additional, Megret, Jerome, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Simon-Loriere, Etienne, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnes, additional, Rey, Felix A., additional, Bruhns, Pierre, additional, Chappert, Pascal, additional, and Mahevas, Matthieu, additional
- Published
- 2021
- Full Text
- View/download PDF
28. mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants
- Author
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Sokal, Aurélien, primary, Barba-Spaeth, Giovanna, additional, Fernández, Ignacio, additional, Broketa, Matteo, additional, Azzaoui, Imane, additional, de La Selle, Andréa, additional, Vandenberghe, Alexis, additional, Fourati, Slim, additional, Roeser, Anais, additional, Meola, Annalisa, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Languille, Laetitia, additional, Michel, Marc, additional, Godeau, Bertrand, additional, Gallien, Sébastien, additional, Melica, Giovanna, additional, Nguyen, Yann, additional, Zarrouk, Virginie, additional, Canoui-Poitrine, Florence, additional, Pirenne, France, additional, Mégret, Jérôme, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Bruhns, Pierre, additional, Rey, Felix A., additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, Chappert, Pascal, additional, and Mahévas, Matthieu, additional
- Published
- 2021
- Full Text
- View/download PDF
29. Intravenous Immunoglobulin as an Immunomodulating Agent in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides: A French Nationwide Study of Ninety-Two Patients
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Crickx, Etienne, Machelart, Irène, Lazaro, Estibaliz, Kahn, Jean-Emmanuel, Cohen-Aubart, Fleur, Martin, Thierry, Mania, Alexandre, Hatron, Pierre-Yves, Hayem, Gilles, Blanchard-Delaunay, Claire, de Moreuil, Claire, Le Guenno, Guillaume, Vandergheynst, Frédéric, Maurier, François, Crestani, Bruno, Dhote, Robin, Silva, Nicolas Martin, Ollivier, Yann, Mehdaoui, Anas, Godeau, Bertrand, Mariette, Xavier, Cadranel, Jacques, Cohen, Pascal, Puéchal, Xavier, Le Jeunne, Claire, Mouthon, Luc, Guillevin, Loïc, and Terrier, Benjamin
- Published
- 2016
- Full Text
- View/download PDF
30. Safety of anti‐SARS‐CoV‐2 vaccination for patients with immune thrombocytopenia
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Crickx, Etienne, primary, Moulis, Guillaume, additional, Ebbo, Mikael, additional, Terriou, Louis, additional, Briantais, Antoine, additional, Languille, Laetitia, additional, Limal, Nicolas, additional, Guillet, Stéphanie, additional, Michel, Marc, additional, Mahevas, Matthieu, additional, and Godeau, Bertrand, additional
- Published
- 2021
- Full Text
- View/download PDF
31. Daratumumab, an original approach for treating multi-refractory autoimmune cytopenia
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Crickx, Etienne, primary, Audia, Sylvain, additional, Robbins, Ailsa, additional, Boutboul, David, additional, Comont, Thibault, additional, Cheminant, Morgane, additional, Oksenhendler, Eric, additional, Godeau, Bertrand, additional, Michel, Marc, additional, and Mahevas, Matthieu, additional
- Published
- 2021
- Full Text
- View/download PDF
32. Molecular Signatures of Kidney Antibody–Secreting Cells in Lupus Patients With Active Nephritis Upon Immunosuppressive Therapy
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Crickx, Etienne, primary, Tamirou, Farah, additional, Huscenot, Tessa, additional, Costedoat‐Chalumeau, Nathalie, additional, Rabant, Marion, additional, Karras, Alexandre, additional, Robbins, Ailsa, additional, Fadeev, Tatiana, additional, Le Guern, Véronique, additional, Remy, Philippe, additional, Hummel, Aurélie, additional, Aydin, Selda, additional, Lauwerys, Bernard, additional, Weill, Jean‐Claude, additional, Reynaud, Claude‐Agnès, additional, Houssiau, Frédéric, additional, and Mahévas, Matthieu, additional
- Published
- 2021
- Full Text
- View/download PDF
33. Hematological disorder associated Cxcr4-gain-of-function mutation leads to uncontrolled extrafollicular immune response Short title: Cxcr4 signaling and the extrafollicular response
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Alouche, Nagham, Bonaud, Amélie, Rondeau, Vincent, Hussein-Agha, Rim, Nguyen, Julie, Bisio, Valeria, Khamyath, Mélanie, Crickx, Etienne, Setterblad, Niclas, Dulphy, Nicolas, Mahevas, Matthieu, Mcdermott, David, Murphy, Philip, Balabanian, Karl, Espéli, Marion, espeli, marion, Impact des SNARE sur la biologie des plasmocytes - - PC-SEC2019 - ANR-19-CE15-0019 - AAPG2019 - VALID, Accueil de Chercheurs de Haut Niveau - Analyse integrative de la biologie des plasmocytes normaux et pathologiques - - AUTO-PLASMO2014 - ANR-14-ACHN-0008 - @RAction - VALID, Autocrinie et paracrinie de l'axe de signalisation CXCL12/CXCR4-CXCR7 dans la niche ostéo-vasculaire: impact sur la spécification et l'engagement lymphoïde des cellules souches hématopoïétiques - - OSTEOVALYMPH2017 - ANR-17-CE14-0019 - AAPG2017 - VALID, Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Université Paris Cité (UPCité), Ecotaxie, microenvironnement et développement lymphocytaire (EMily (UMR_S_1160 / U1160)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CNRS GDR 3697 MicroNiT, Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), National Institutes of Health [Bethesda] (NIH), ANR-19-CE15-0019,PC-SEC,Impact des SNARE sur la biologie des plasmocytes(2019), ANR-14-ACHN-0008,AUTO-PLASMO,Analyse integrative de la biologie des plasmocytes normaux et pathologiques(2014), ANR-17-CE14-0019,OSTEOVALYMPH,Autocrinie et paracrinie de l'axe de signalisation CXCL12/CXCR4-CXCR7 dans la niche ostéo-vasculaire: impact sur la spécification et l'engagement lymphoïde des cellules souches hématopoïétiques(2017), Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
- Subjects
[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology ,[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology ,[SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology - Abstract
International audience; The extrafollicular immune response is essential to generate a rapid but transient wave of protective antibodies upon infection. Despite its importance, the molecular mechanisms controlling this first response are poorly understood. Here, we demonstrate that enhanced Cxcr4 signaling due to defective receptor desensitization leads to exacerbated extrafollicular B cell response. Using a mouse model bearing a gain of function mutation of Cxcr4 described in two human hematological disorders, WHIM syndrome and Waldenström's Macroglobulinemia, we demonstrated that mutant B cells exhibited enhanced mTOR signaling, cycled more and differentiated more potently into plasma cells than wild-type B cells upon TLR stimulation. Moreover, Cxcr4 gain-of-function promoted enhanced homing and persistence of immature plasma cells in the bone marrow, a phenomenon recapitulated in WHIM syndrome patient samples. This translated in increased and more sustained production of antibodies upon Tindependent immunization in Cxcr4 mutant mice. Thus, our results establish that fine-tuning of Cxcr4 signaling is essential to limit the strength and length of the extrafollicular immune response.
- Published
- 2021
34. Single-cell analyses of immune thrombocytopenic patients reveal multiorgan dissemination of high-affinity autoreactive plasma cells
- Author
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Canales-Herrerias, Pablo, primary, Crickx, Etienne, additional, Broketa, Matteo, additional, Sokal, Aurélien, additional, Chenon, Guilhem, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Perima, Angga, additional, Iannascoli, Bruno, additional, Goff, Odile Richard-Le, additional, Castrillon, Carlos, additional, Mottet, Guillaume, additional, Sterlin, Delphine, additional, Robbins, Ailsa, additional, Michel, Marc, additional, England, Patrick, additional, Millot, Gael A., additional, Eyer, Klaus, additional, Baudry, Jean, additional, Mahevas, Matthieu, additional, and Bruhns, Pierre, additional
- Published
- 2021
- Full Text
- View/download PDF
35. Memory B cells control SARS-CoV-2 variants upon mRNA vaccination of naive and COVID-19 recovered individuals
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Sokal, Aurélien, primary, Barba-Spaeth, Giovanna, additional, Fernández, Ignacio, additional, Broketa, Matteo, additional, Azzaoui, Imane, additional, La Selle, Andrea de, additional, Vandenberghe, Alexis, additional, Fourati, Slim, additional, Roeser, Anais, additional, Meola, Annalisa, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Languille, Laetitia, additional, Michel, Marc, additional, Godeau, Bertrand, additional, Gallien, Sébastien, additional, Melica, Giovanna, additional, Nguyen, Yann, additional, Zarrouk, Virginie, additional, Canoui-Poitrine, Florence, additional, Noizat-Pirenne, France, additional, Megret, Jérôme, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Bruhns, Pierre, additional, Rey, Felix A., additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, Chappert, Pascal, additional, and Mahévas, Matthieu, additional
- Published
- 2021
- Full Text
- View/download PDF
36. Rituximab-resistant splenic memory B cells and newly engaged naive B cells fuel relapses in patients with immune thrombocytopenia
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Crickx, Etienne, primary, Chappert, Pascal, additional, Sokal, Aurélien, additional, Weller, Sandra, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Bonnard, Guillaume, additional, Rossi, Geoffrey, additional, Fadeev, Tatiana, additional, Storck, Sébastien, additional, Fadlallah, Jehane, additional, Meignin, Véronique, additional, Rivière, Etienne, additional, Audia, Sylvain, additional, Godeau, Bertrand, additional, Michel, Marc, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, and Mahévas, Matthieu, additional
- Published
- 2021
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- View/download PDF
37. B‐cell responses to ITP treatments.
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Crickx, Etienne and Mahévas, Matthieu
- Subjects
- *
REGULATORY B cells , *IDIOPATHIC thrombocytopenic purpura - Abstract
Deficiency in regulatory B cells has been suggested in immune thrombocytopenia. In this study, Stimpson et al. emphasize the importance of considering the treatments received for immunological analyses. Commentary on: Stimpson et al. Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia. Br J Haematol 2024;204:644‐648. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
38. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
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Sokal, Aurélien, primary, Chappert, Pascal, additional, Barba-Spaeth, Giovanna, additional, Roeser, Anais, additional, Fourati, Slim, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Fernandez, Ignacio, additional, Meola, Annalisa, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Beldi-Ferchiou, Asma, additional, Hue, Sophie, additional, Languille, Laetitia, additional, Michel, Marc, additional, Baloul, Samia, additional, Noizat-Pirenne, France, additional, Luka, Marine, additional, Mégret, Jérôme, additional, Ménager, Mickaël, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Rey, Felix A., additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, and Mahévas, Matthieu, additional
- Published
- 2021
- Full Text
- View/download PDF
39. Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus
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Jeanpierre, Marie, Cognard, Jade, Tusseau, Maud, Riller, Quentin, Bui, Linh-Chi, Berthelet, Jérémy, Laurent, Audrey, Crickx, Etienne, Parlato, Marianna, Stolzenberg, Marie-Claude, Suarez, Felipe, Leverger, Guy, Aladjidi, Nathalie, Collardeau-Frachon, Sophie, Pietrement, Christine, Malphettes, Marion, Froissart, Antoine, Bole-Feysot, Christine, Cagnard, Nicolas, Rodrigues Lima, Fernando, Walzer, Thierry, Rieux-Laucat, Frédéric, Belot, Alexandre, and Mathieu, Anne-Laure
- Abstract
An exome sequencing strategy employed to identify pathogenic variants in patients with pediatric-onset systemic lupus or Evans syndrome resulted in the discovery of six novel monoallelic mutations in PTPN2. PTPN2 is a phosphatase that acts as an essential negative regulator of the JAK/STAT pathways. All mutations led to a loss of PTPN2 regulatory function as evidenced by in vitro assays and by hyperproliferation of patients’ T cells. Furthermore, patients exhibited high serum levels of inflammatory cytokines, mimicking the profile observed in individuals with gain-of-function mutations in STAT factors. Flow cytometry analysis of patients’ blood cells revealed typical alterations associated with autoimmunity and all patients presented with autoantibodies. These findings further supported the notion that a loss of function in negative regulators of cytokine pathways can lead to a broad spectrum of autoimmune manifestations and that PTPN2 along with SOCS1 haploinsufficiency constitute a new group of monogenic autoimmune diseases that can benefit from targeted therapy.
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- 2024
- Full Text
- View/download PDF
40. Convalescent plasma therapy for B-cell depleted patients with protracted COVID-19 disease
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Hueso, Thomas, Pouderoux, Cécile, Péré, Hélène, Beaumont, Anne-Lise, Raillon, Laure-Anne, Ader, Florence, Chatenoud, Lucienne, Eshagh, Déborah, Szwebel, Tali-Anne, Martinot, Martin, Camou, Fabrice, Crickx, Etienne, Michel, Marc, Mahevas, Matthieu, Boutboul, David, Azoulay, Elie, Joseph, Adrien, Hermine, Olivier, Rouzaud, Claire, Faguer, Stanislas, Petua, Philippe, Pommeret, Fanny, Clerc, Sébastien, Planquette, Benjamin, Merabet, Fatiha, London, Jonathan, Zeller, Valérie, Ghez, David, Veyer, David, Ouedrani, Amani, Gallian, Pierre, Pacanowski, Jérôme, Mékinian, Arsène, Garnier, Marc, Pirenne, France, Tiberghien, Pierre, Lacombe, Karine, University of Paris Sud (UPSUD), Croix-Rousse Hospital, Hospices civils de Lyon, Vascular and Oncological Interventional Radiology, Inserm U970, Paris Cardiovascular Research Centre, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, Unité des Virus Emergents (UVE), Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
[SDV]Life Sciences [q-bio] - Abstract
International audience; Anti-CD20 monoclonal antibodies are widely used for the treatment of hematological malignancies or autoimmune disease but may be responsible for a secondary humoral deficiency. In the context of COVID-19 infection, this may prevent the elicitation of a specific SARS-CoV-2-antibody response. We report a series of 17 consecutive patients with profound B-cell lymphopenia and prolonged COVID-19 symptoms, negative IgG-IgM SARS-CoV-2 serology and a positive RNAemia measured by digital PCR who were treated with four units of COVID-19 convalescent plasma. Within 48 hours following transfusion, all patients except one experienced an amelioration of their clinical symptoms. The inflammatory syndrome abated within a week. Only one patient who needed mechanical ventilation for severe COVID-19 disease died of bacterial pneumonia. SARS-CoV-2 RNAemia decreased to below the sensitivity threshold in 9 out of 9 evaluated patients. Analysis of virus-specific T-cell responses using T-cell enzyme linked immunoSpot (ELISPOT) assay was analyzed before convalescent plasma transfusion in 3 patients. All showed a conserved SARS-CoV-2 T-cell response and poor cross-response to other coronaviruses. No adverse event was reported. In COVID-19 patients unable to mount a specific humoral response to SARS-CoV-2, convalescent plasma with anti-SARS-CoV-2 antibodies appears to be a very promising approach in the context of protracted COVID-19 symptoms.
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- 2020
41. No evidence of clinical efficacy of hydroxychloroquine in patients hospitalized for COVID-19 infection with oxygen requirement: results of a study using routinely collected data to emulate a target trial
- Author
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Mahevas, Matthieu, Tran, Viet-Thi, Roumier, Mathilde, Chabrol, Amelie, Paule, Romain, Guillaud, Constance, Gallien, Sebastien, Lepeule, Raphael, Szwebel, Tali-Anne, Lescure, Xavier, Schlemmer, Frederic, Matignon, Marie, Khellaf, Mehdi, Crickx, Etienne, Terrier, Benjamin, Morbieu, Caroline, Legendre, Paul, Dang, Julien, Schoindre, Yoland, Pawlotski, Jean-Michel, Michel, Marc, Perrodeau, Elodie, Carlier, Nicolas, Roche, Nicolas, De Lastours, Victoire, Mouthon, Luc, Audureau, Etienne, Ravaud, Philippe, Godeau, Bertrand, and Costedoat, Nathalie
- Abstract
Background Treatments are urgently needed to prevent respiratory failure and deaths from coronavirus disease 2019 (COVID-19). Hydroxychloroquine (HCQ) has received worldwide attention because of positive results from small studies. Methods We used data collected from routine care of all adults in 4 French hospitals with documented SARS-CoV-2 pneumonia and requiring oxygen ≥ 2 L/min to emulate a target trial aimed at assessing the effectiveness of HCQ at 600 mg/day. The composite primary endpoint was transfer to intensive care unit (ICU) within 7 days from inclusion and/or death from any cause. Analyses were adjusted for confounding factors by inverse probability of treatment weighting. Results This study included 181 patients with SARS-CoV-2 pneumonia; 84 received HCQ within 48 hours of admission (HCQ group) and 97 did not (no-HCQ group). Initial severity was well balanced between the groups. In the weighted analysis, 20.2% patients in the HCQ group were transferred to the ICU or died within 7 days vs 22.1% in the no-HCQ group (16 vs 21 events, relative risk [RR] 0.91, 95% CI 0.47-1.80). In the HCQ group, 2.8% of the patients died within 7 days vs 4.6% in the no-HCQ group (3 vs 4 events, RR 0.61, 95% CI 0.13-2.89), and 27.4% and 24.1%, respectively, developed acute respiratory distress syndrome within 7 days (24 vs 23 events, RR 1.14, 95% CI 0.65-2.00). Eight patients receiving HCQ (9.5%) experienced electrocardiogram modifications requiring HCQ discontinuation. Interpretation These results do not support the use of HCQ in patients hospitalised for documented SARS-CoV-2-positive hypoxic pneumonia.
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- 2020
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42. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
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Sokal, Aurélien, primary, Chappert, Pascal, additional, Roeser, Anais, additional, Barba-Spaeth, Giovanna, additional, Fourati, Slim, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Fernandez, Ignacio, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Ferchiou, Asma Beldi, additional, Hue, Sophie, additional, Languille, Laetitia, additional, Baloul, Samia, additional, Noizat-Pirenne, France, additional, Luka, Marine, additional, Megret, Jérôme, additional, Ménager, Mickaël, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Rey, Felix A, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, and Mahévas, Matthieu, additional
- Published
- 2020
- Full Text
- View/download PDF
43. Efficacy and Safety of a Combination of Thrombopoietin Receptor Agonist with an Immunosuppressant Therapy for the Management of Multirefractory Adult ITP: Results from a Retrospective, Multicenter, Observational Study
- Author
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Crickx, Etienne, primary, Moulis, Guillaume, additional, Ruivard, Marc, additional, Asli, Bouchra, additional, Marolleau, Jean Pierre, additional, Ebbo, Mikael, additional, Riviere, Etienne, additional, Audia, Sylvain, additional, Terriou, Louis, additional, Michel, Marc, additional, Godeau, Bertrand, additional, and Mahevas, Matthieu, additional
- Published
- 2020
- Full Text
- View/download PDF
44. Clinical characteristics, management and outcome of COVID‐19‐associated immune thrombocytopenia: a French multicentre series
- Author
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Mahévas, Matthieu, primary, Moulis, Guillaume, additional, Andres, Emmanuel, additional, Riviere, Etienne, additional, Garzaro, Margaux, additional, Crickx, Etienne, additional, Guillotin, Vivien, additional, Malphettes, Marion, additional, Galicier, Lionel, additional, Noel, Nicolas, additional, Darnige, Luc, additional, Terriou, Louis, additional, Guerveno, Claire, additional, Sanchis‐Borja, Mateo, additional, Moulinet, Thomas, additional, Meunier, Benoit, additional, Ebbo, Mikael, additional, Michel, Marc, additional, and Godeau, Bertrand, additional
- Published
- 2020
- Full Text
- View/download PDF
45. No evidence of clinical efficacy of hydroxychloroquine in patients hospitalised for COVID-19 infection and requiring oxygen: results of a study using routinely collected data to emulate a target trial
- Author
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Mahévas, Matthieu, primary, Tran, Viet-Thi, additional, Roumier, Mathilde, additional, Chabrol, Amélie, additional, Paule, Romain, additional, Guillaud, Constance, additional, Gallien, Sébastien, additional, Lepeule, Raphael, additional, Szwebel, Tali-Anne, additional, Lescure, Xavier, additional, Schlemmer, Frédéric, additional, Matignon, Marie, additional, Khellaf, Medhi, additional, Crickx, Etienne, additional, Terrier, Benjamin, additional, Morbieu, Caroline, additional, Legendre, Paul, additional, Dang, Julien, additional, Schoindre, Yoland, additional, Pawlotski, Jean-Michel, additional, Michel, Marc, additional, Perrodeau, Elodie, additional, Carlier, Nicolas, additional, Roche, Nicolas, additional, de Lastours, Victoire, additional, Mouthon, Luc, additional, Audureau, Etienne, additional, Ravaud, Philippe, additional, Godeau, Bertrand, additional, and Costedoat-Chalumeau, Nathalie, additional
- Published
- 2020
- Full Text
- View/download PDF
46. O19 Evolution of kidney antibody secreting cells molecular signature in lupus patients with active nephritis upon immunosuppressive therapy
- Author
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Crickx, Etienne, primary, Tamirou, Farah, additional, Huscenot, Tessa, additional, Costedoat, Nathalie, additional, Rabant, Marion, additional, Karras, Alexandre, additional, Fadeev, Tatiana, additional, Guern, Véronique Le, additional, Remy, Philippe, additional, Hummel, Aurélie, additional, Lauwerys, Bernard, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, Houssiau, Frédéric, additional, and Mahévas, Matthieu, additional
- Published
- 2020
- Full Text
- View/download PDF
47. A reservoir of rituximab-resistant splenic memory B cells contributes to relapses after B-cell depletion therapy
- Author
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Crickx, Etienne, primary, Chappert, Pascal, additional, Weller, Sandra, additional, Sokal, Aurélien, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Bonnard, Guillaume, additional, Rossi, Geoffrey, additional, Fadeev, Tatiana, additional, Storck, Sébastien, additional, Galicier, Lionel, additional, Meignin, Véronique, additional, Rivière, Etienne, additional, Godeau, Bertrand, additional, Michel, Marc, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, and Mahévas, Matthieu, additional
- Published
- 2019
- Full Text
- View/download PDF
48. DPP4 inhibitor-induced polyarthritis: a report of three cases
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Crickx, Etienne, Marroun, Ibrahim, Veyrie, Christine, Le Beller, Christine, Schoindre, Yoland, Bouilloud, Florence, Blétry, Olivier, and Kahn, Jean-Emmanuel
- Published
- 2014
- Full Text
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49. Bortezomib and dexamethasone, an original approach for treating multi‐refractory warm autoimmune haemolytic anaemia
- Author
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Fadlallah, Jehane, primary, Michel, Marc, additional, Crickx, Etienne, additional, Limal, Nicolas, additional, Costedoat, Nathalie, additional, Malphettes, Marion, additional, Fieschi, Claire, additional, Galicier, Lionel, additional, Oksenhendler, Eric, additional, Godeau, Bertrand, additional, Audia, Sylvain, additional, and Mahévas, Matthieu, additional
- Published
- 2019
- Full Text
- View/download PDF
50. THU0211 EVOLUTION OF KIDNEY ANTIBODY SECRETING CELLS MOLECULAR SIGNATURE IN LUPUS PATIENTS WITH ACTIVE NEPHRITIS UPON IMMUNOSUPPRESSIVE THERAPY
- Author
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Crickx, Etienne, primary, Tamirou, Farah, additional, Huscenot, Tessa, additional, Costedoat-Chalumeau, Nathalie, additional, Rabant, Marion, additional, Karras, Alexandre, additional, Robbins, Ailsa, additional, Fadeev, Tatiana, additional, Guern, Véronique Le, additional, Remy, Philippe, additional, Hummel, Aurélie, additional, Godeau, Bertrand, additional, Lauwerys, Bernard, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, Houssiau, Frederic, additional, and Mahévas, Matthieu, additional
- Published
- 2019
- Full Text
- View/download PDF
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