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5. Clinical Trial on Solid Second-Generation Platelet-Concentrates in the Management of the Chronic Osteomyelitis: Advanced Bioregenerative Surgeries.

Author

Crisci, Alessandro, Raffaele, D'Adamo, and Crisci, Michela

Abstract

The supposition is that the usage of fibrin rich in leukocytes and platelets advanced (A-PRF) in ulcerative osteomyelitis of the diabetic foot allows rehabilitation from this critical illness. In this investigation, the focus was to normalize the use of platelet-rich fibrin (PRF) in patients with osteomyelitis not amputated, to use this second-generation platelet concentrate as a regeneration enabler. The researchers submitted and utilized A-PRF membranes (1300 g × 8 min) in 7 patients (all diabetics) with osteomyelitis and cutaneous injury for 6 months. The membranes, in combination with the supernatant fluid produced by stress, have been integrated into the skin lesion down to the bone after surgical debridement. The advancement of the lesions after some period of time has been analyzed. All 7 subjects had a probe-to-bone positive assay; magnetic resonance imaging indicated cortico-periosteal coagulation and/or foci of cortico-spongeous osteolysis contiguous to the lesion. Gram-positive bacteria were identified in our procedures in 52% of cases. Gram + Cocci, for example, Staphylococcus aureus (15.6%), β-hemolytic Streptococci (12.1%), Streptococcus viridans (7.1%), and Gram-negative bacteria, for example, Pseudomonas (10.6%), Proteus (7.8%), Enterobacter (5.7%) were present. Candida albicans was active in 2.8% of cases. The blood count showed no relevant differences. To date, cutaneous lesions have been cured in 6 of the 7 subjects treated (1 patient for more than 6 years) without any evidence of infection or recurrence. The results obtained on our subjects indicate that PRF membranes may be a therapeutic option in this problematic disease. In fact, this clinical approach may have the potential to promote the healing of diabetic skin lesions with osteomyelitis. [ABSTRACT FROM AUTHOR]

Published
2023
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17. La voce dei ragazzi 'per fermare' la febbre del pianeta. Proposte sul clima verso e oltre COP21. #Teens4Change

Author

Caminiti, Natale Massimo, Velardi, Maria, Del Colle, Caterina, Vizza, Domenico, Vagliasindi, Maria Beatrice, Tritto, Carlo, Silvestri, Martino, Pulitelli, Gaia, Polito, Simone, Moroli, Ludovico, Marsili, Giuliano, Levrero, Flavia, Leonardi, Alessandro, Crisci, Alessandro, Caravetta, Alessia, Brandi, Edoardo, Barnocchi, Annia, Accroglianò, Giuseppe, Caminiti, Natale Massimo, Velardi, Maria, Del Colle, Caterina, Vizza, Domenico, Vagliasindi, Maria Beatrice, Tritto, Carlo, Silvestri, Martino, Pulitelli, Gaia, Polito, Simone, Moroli, Ludovico, Marsili, Giuliano, Levrero, Flavia, Leonardi, Alessandro, Crisci, Alessandro, Caravetta, Alessia, Brandi, Edoardo, Barnocchi, Annia, and Accroglianò, Giuseppe

Subjects
Sostenibilità, Conferenza delle Nazioni Unite di Parigi, Cambiamento climatico, Green economy
Abstract

Teens4Change è una raccolta di proposte e inviti ad agire per contrastare il cambiamento climatico di un gruppo di studenti del Liceo Scientifico Avogadro di Roma, ispirati da un ciclo di lezioni tenute sul tema da alcuni ricercatori dell’ENEA nell’ambito del Progetto “L’Europa che vorrei: da Ventotene a Strasburgo”. La pubblicazione è indirizzata principalmente ai giovani ma vuole anche essere un messaggio per i decisori della Conferenza delle Nazioni Unite di Parigi. Il volume tratta i temi del cambiamento climatico facendone emergere necessità e urgenza e passa in rassegna gli strumenti per contrastare i gas a effetto serra: le nuove tecnologie e l’efficienza energetica, le azioni da intraprendere per l’adattamento e la mitigazione, gli strumenti per ridurne l’impatto sull’uomo e l’ambiente. L’ENEA ha ascoltato e sostenuto i ragazzi in questa sfida pubblicando il volume.

Published
2015

21. The Ischemic/Septic Diabetic Hand: Review of Literature and a Case Report

Author

Crisci Alessandro, Crisci Michela, Lombardi Domenico, Romano Giovanni, Lombardi Guido, and Lombardi Luisa

Subjects
030222 orthopedics, medicine.medical_specialty, medicine.drug_class, business.industry, medicine.medical_treatment, Antibiotics, Ischemia, Soft tissue, Disease, 030230 surgery, medicine.disease, Surgery, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Amputation, Diabetes mellitus, medicine, Contracture, medicine.symptom, business
Abstract

The term “diabetic hand” was born to describe the complications of the diabetes mellitus on the hand resulting in a rigid hand with a poor mobility. The traumatic wounds with soft tissue involvement increase the risk of infection. Staphylococcus aureus methicillin-resistant (MRSA) is the most common bacterium isolated in the hand infections. The case report of a type 2 diabetic patient, dialysed with chronic obstructive peripheral artery disease and Monckeberg sclerosis of the vessels of the hands, ischemic necrosis of the right hand fingers is reported by the authors. In the diabetic patient the hands can be infected in the same way that feet could be infected too. Several amputation interventions have been performed with the intent of saving part of the hand. The diabetic hand syndrome (DHS) is an important pathology that requires strong antibiotics and surgery to avoid severe disability as rigidity, contracture and amputation. Apparently, in the last years good results are reported using antibiotic, surgical and hyperbaric treatment. In conclusion it would be wrong to ignore or underestimate this disease and any doctor should practice a scrupulous visit of the hands in the diabetic patient.

Published
2018

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