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1. Viral suppression and retention in HIV care during the postpartum period among women living with HIV: a longitudinal multicenter cohort study

Author

Abela, I., Aebi-Popp, K., Anagnostopoulos, A., Battegay, M., Baumann, M., Bernasconi, E., Braun, D.L., Bucher, H.C., Calmy, A., Cavassini, M., Ciuffi, A., Crisinel, P.A., Darling, K., Duppenthaler, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francini, K., Furrer, H., Fux, C.A., Günthard, H.F., Hachfeld, A., Haerry, D., Hasse, B., Hirsch, H.H., Hoffmann, M., Hösli, I., Huber, M., Jackson-Perry, D., Kahlert, C.R., Kaiser, L., Kapfhammer, E., Keiser, O., Klimkait, T., Kohns, M., Kottanattu, L., Kouyos, R.D., Kovari, H., Kusejko, K., Labhardt, N., Martinez de Tejada, B., Marzolini, C., Metzner, K.J., Müller, N., Nemeth, J., Nicca, D., Notter, J., Paioni, P., Pantaleo, G., Perreau, M., Polli, Ch, Rauch, A., Salazar-Vizcaya, L., Schmid, P., Speck, R., Stöckle, M., Tarr, P., Thanh Lecompte, M., Trkola, A., Wagner, N., Wandeler, G., Weisser, M., Yerly, S., Paioni, Paolo, Aebi-Popp, Karoline, Martinez de Tejada, Begoña, Rudin, Christoph, Bernasconi, Enos, Braun, Dominique L., Kouyos, Roger, Wagner, Noémie, Crisinel, Pierre Alex, Güsewell, Sabine, Darling, Katharine E.A., Duppenthaler, Andrea, Baumann, Marc, Polli, Christian, Fischer, Tina, and Kahlert, Christian R.

Published
2023
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6. Den Risikofaktoren für eine infektiöse Endokarditis auf der Spur

Author

Knirsch, Walter, primary, Schuler, Stefanie Katharina, additional, Crisinel, Pierre Alex, additional, Joye, Raphael, additional, Rohr, Marie, additional, Bressieux-Degueldre, Sabrina, additional, Glckler, Martin, additional, Paioni, Paolo, additional, Agyeman, Philipp K. A., additional, and Sendi, Parham, additional

Published
2023
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7. À la recherche des facteurs de risque de l’endocardite infectieuse

Author

Knirsch, Walter, primary, Schuler, Stefanie Katharina, additional, Crisinel, Pierre Alex, additional, Joye, Raphael, additional, Rohr, Marie, additional, Bressieux-Degueldre, Sabrina, additional, Glckler, Martin, additional, Paioni, Paolo, additional, Agyeman, Philipp K. A., additional, and Sendi, Parham, additional

Published
2023
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8. Viral suppression and retention in HIV care during the postpartum period among women living with HIV: a longitudinal multicenter cohort study

Author

Paioni, Paolo, primary, Aebi-Popp, Karoline, additional, Martinez de Tejada, Begoña, additional, Rudin, Christoph, additional, Bernasconi, Enos, additional, Braun, Dominique L., additional, Kouyos, Roger, additional, Wagner, Noémie, additional, Crisinel, Pierre Alex, additional, Güsewell, Sabine, additional, Darling, Katharine E.A., additional, Duppenthaler, Andrea, additional, Baumann, Marc, additional, Polli, Christian, additional, Fischer, Tina, additional, Kahlert, Christian R., additional, Abela, I., additional, Aebi-Popp, K., additional, Anagnostopoulos, A., additional, Battegay, M., additional, Baumann, M., additional, Bernasconi, E., additional, Braun, D.L., additional, Bucher, H.C., additional, Calmy, A., additional, Cavassini, M., additional, Ciuffi, A., additional, Crisinel, P.A., additional, Darling, K., additional, Duppenthaler, A., additional, Dollenmaier, G., additional, Egger, M., additional, Elzi, L., additional, Fehr, J., additional, Fellay, J., additional, Francini, K., additional, Furrer, H., additional, Fux, C.A., additional, Günthard, H.F., additional, Hachfeld, A., additional, Haerry, D., additional, Hasse, B., additional, Hirsch, H.H., additional, Hoffmann, M., additional, Hösli, I., additional, Huber, M., additional, Jackson-Perry, D., additional, Kahlert, C.R., additional, Kaiser, L., additional, Kapfhammer, E., additional, Keiser, O., additional, Klimkait, T., additional, Kohns, M., additional, Kottanattu, L., additional, Kouyos, R.D., additional, Kovari, H., additional, Kusejko, K., additional, Labhardt, N., additional, Martinez de Tejada, B., additional, Marzolini, C., additional, Metzner, K.J., additional, Müller, N., additional, Nemeth, J., additional, Nicca, D., additional, Notter, J., additional, Paioni, P., additional, Pantaleo, G., additional, Perreau, M., additional, Polli, Ch, additional, Rauch, A., additional, Salazar-Vizcaya, L., additional, Schmid, P., additional, Speck, R., additional, Stöckle, M., additional, Tarr, P., additional, Thanh Lecompte, M., additional, Trkola, A., additional, Wagner, N., additional, Wandeler, G., additional, Weisser, M., additional, and Yerly, S., additional

Published
2023
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9. Viral suppression and retention in HIV care during the postpartum period among women living with HIV: a longitudinal multicenter cohort study

Author

Paioni, Paolo, Aebi-Popp, Karoline, Martinez de Tejada, Begoña, Rudin, Christoph, Bernasconi, Enos, Braun, Dominique L, Kouyos, Roger, Wagner, Noémie, Crisinel, Pierre Alex, Güsewell, Sabine, Darling, Katharine E A, Duppenthaler, Andrea, Baumann, Marc, Polli, Christian, Fischer, Tina, and Kahlert, Christian R

Subjects
610 Medicine & health
Abstract

BACKGROUND Low rates of postnatal retention in HIV care and viral suppression have been reported in women living with HIV (WLWH) despite viral suppression at delivery. At the same time, postpartum follow-up is of crucial importance in light of the increasing support offered in many resource-rich countries including Switzerland to WLWH choosing to breastfeed their infant, if optimal scenario criteria are met. METHODS We longitudinally investigated retention in HIV care, viral suppression, and infant follow-up in a prospective multicentre HIV cohort study of WLWH in the optimal scenario who had a live birth between January 2000 and December 2018. Risk factors for adverse outcomes in the first year postpartum were assessed using logistic and proportional hazard models. FINDINGS Overall, WLWH were retained in HIV care for at least six months after 94.2% of the deliveries (694/737). Late start of combination antiretroviral therapy (cART) during the third trimester was found to be the main risk factor for failure of retention in HIV care (crude odds ratio [OR] 3.91; 95% confidence interval [CI], 1.50-10.22; p = 0.005). Among mothers on cART until at least one year after delivery, 4.4% (26/591) experienced viral failure, with illicit drugs use being the most important risk factor (hazard ratio [HR], 13.2; 95% CI, 2.35-73.6; p = 0.003). The main risk factors for not following the recommendations regarding infant follow-up was maternal depression (OR, 3.52; 95% CI, 1.18-10.52; p = 0.024). INTERPRETATION Although the results are reassuring, several modifiable risk factors for adverse postpartum outcome, such as late treatment initiation and depression, were identified. These factors should be addressed in HIV care of all WLWH, especially those opting to breastfeed in resource-rich countries. FUNDING This study has been financed within the framework of the Swiss HIV Cohort Study, supported by the Swiss National Science Foundation (grant #201369), by SHCS project 850 and by the SHCS research foundation.

Published
2023
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10. Successful implementation of new Swiss recommendations on breastfeeding of infants born to women living with HIV

Author

Crisinel, Pierre Alex; https://orcid.org/0000-0002-1967-8255, Kusejko, Katharina; https://orcid.org/0000-0002-4638-1940, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, Beyer, Leila Sultan, de Tejada, Begoña Martinez, Hösli, Irene, Vasconcelos, Malte Kohns, Baumann, Marc, Darling, Katharine; https://orcid.org/0000-0003-1449-3873, Duppenthaler, Andrea, Rauch, Andri; https://orcid.org/0000-0001-5297-6062, Paioni, Paolo; https://orcid.org/0000-0002-3904-1606, Aebi-Popp, Karoline; https://orcid.org/0000-0002-9337-900X, Crisinel, Pierre Alex; https://orcid.org/0000-0002-1967-8255, Kusejko, Katharina; https://orcid.org/0000-0002-4638-1940, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, Beyer, Leila Sultan, de Tejada, Begoña Martinez, Hösli, Irene, Vasconcelos, Malte Kohns, Baumann, Marc, Darling, Katharine; https://orcid.org/0000-0003-1449-3873, Duppenthaler, Andrea, Rauch, Andri; https://orcid.org/0000-0001-5297-6062, Paioni, Paolo; https://orcid.org/0000-0002-3904-1606, and Aebi-Popp, Karoline; https://orcid.org/0000-0002-9337-900X

Abstract

INTRODUCTION: Swiss national recommendations advise, since end of 2018, supporting women with HIV who wish to breastfeed. Our objective is to describe the motivational factors and the outcome of these women and of their infants. METHODS: mothers included in MoCHiV with a delivery between January 2019 and February 2021 who fulfilled the criteria of the "optimal scenario" (adherence to cART, regular clinical care, and suppressed HIV plasma viral load (pVL) of <50 RNA copies/ml) and who decided to breastfeed after a shared decision-making process, were approached to participate in this nested study and asked to fill-in a questionnaire exploring the main motivating factors for breastfeeding. RESULTS: Between January 9, 2019 and February 7, 2021, 41 women gave birth, and 25 decided to breastfeed of which 20 accepted to participate in the nested study. The three main motivational factors of these women were bonding, neonatal and maternal health benefits. They breastfed for a median duration of 6.3 months (range 0.7-25.7, IQR 2.5-11.1). None of the breastfed neonates received HIV post-exposure prophylaxis. There was no HIV transmission: 24 infants tested negative for HIV at least 3 months after weaning; one mother was still breastfeeding when we analyzed the data. CONCLUSIONS: As a result of a shared decision-making process, a high proportion of mothers expressed a desire to breastfeed. No breastfed infant acquired HIV. The surveillance of breastfeeding mother-infant pairs in high resource settings should be continued to help update guidelines and recommendations.

Published
2023

11. Viral suppression and retention in HIV care during the postpartum period among women living with HIV: a longitudinal multicenter cohort study

Author

Paioni, Paolo; https://orcid.org/0000-0002-3904-1606, Aebi-Popp, Karoline; https://orcid.org/0000-0002-9337-900X, Martinez de Tejada, Begoña, Rudin, Christoph, Bernasconi, Enos; https://orcid.org/0000-0002-9724-8373, Braun, Dominique L; https://orcid.org/0000-0003-4036-1030, Kouyos, Roger; https://orcid.org/0000-0002-9220-8348, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, Crisinel, Pierre Alex; https://orcid.org/0000-0002-1967-8255, Güsewell, Sabine; https://orcid.org/0000-0001-8442-8888, Darling, Katharine E A; https://orcid.org/0000-0003-1449-3873, Duppenthaler, Andrea, Baumann, Marc, Polli, Christian, Fischer, Tina, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, Swiss HIV Cohort Study (SHCS) and the Swiss Mother and Child HIV, Paioni, Paolo; https://orcid.org/0000-0002-3904-1606, Aebi-Popp, Karoline; https://orcid.org/0000-0002-9337-900X, Martinez de Tejada, Begoña, Rudin, Christoph, Bernasconi, Enos; https://orcid.org/0000-0002-9724-8373, Braun, Dominique L; https://orcid.org/0000-0003-4036-1030, Kouyos, Roger; https://orcid.org/0000-0002-9220-8348, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, Crisinel, Pierre Alex; https://orcid.org/0000-0002-1967-8255, Güsewell, Sabine; https://orcid.org/0000-0001-8442-8888, Darling, Katharine E A; https://orcid.org/0000-0003-1449-3873, Duppenthaler, Andrea, Baumann, Marc, Polli, Christian, Fischer, Tina, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, and Swiss HIV Cohort Study (SHCS) and the Swiss Mother and Child HIV

Abstract

BACKGROUND: Low rates of postnatal retention in HIV care and viral suppression have been reported in women living with HIV (WLWH) despite viral suppression at delivery. At the same time, postpartum follow-up is of crucial importance in light of the increasing support offered in many resource-rich countries including Switzerland to WLWH choosing to breastfeed their infant, if optimal scenario criteria are met. METHODS: We longitudinally investigated retention in HIV care, viral suppression, and infant follow-up in a prospective multicentre HIV cohort study of WLWH in the optimal scenario who had a live birth between January 2000 and December 2018. Risk factors for adverse outcomes in the first year postpartum were assessed using logistic and proportional hazard models. FINDINGS: Overall, WLWH were retained in HIV care for at least six months after 94.2% of the deliveries (694/737). Late start of combination antiretroviral therapy (cART) during the third trimester was found to be the main risk factor for failure of retention in HIV care (crude odds ratio [OR] 3.91; 95% confidence interval [CI], 1.50-10.22; p = 0.005). Among mothers on cART until at least one year after delivery, 4.4% (26/591) experienced viral failure, with illicit drugs use being the most important risk factor (hazard ratio [HR], 13.2; 95% CI, 2.35-73.6; p = 0.003). The main risk factors for not following the recommendations regarding infant follow-up was maternal depression (OR, 3.52; 95% CI, 1.18-10.52; p = 0.024). INTERPRETATION: Although the results are reassuring, several modifiable risk factors for adverse postpartum outcome, such as late treatment initiation and depression, were identified. These factors should be addressed in HIV care of all WLWH, especially those opting to breastfeed in resource-rich countries. FUNDING: This study has been financed within the framework of the Swiss HIV Cohort Study, supported by the Swiss National Science Foundation (grant #201369), by SHCS project 850 and b

Published
2023

12. Estimating glomerular filtration rate from serum creatinine concentration in children with augmented renal clearance: all formulas are equivocal, but some are more equivocal than others

Author

André, Pascal, primary, Chtioui, Haithem, additional, Dao, Kim, additional, Rothuizen, Laura E., additional, Di Paolo, Ermindo R., additional, Diezi, Manuel, additional, Crisinel, Pierre-Alex, additional, Cachat, François, additional, Chehade, Hassib, additional, and Buclin, Thierry, additional

Published
2023
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17. Swiss recommendations on perioperative antimicrobial prophylaxis in children

Author

Paioni, Paolo; https://orcid.org/0000-0002-3904-1606, Aebi, Christoph; https://orcid.org/0000-0003-3554-7949, Bielicki, Julia; https://orcid.org/0000-0002-3902-5489, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Crisinel, Pierre Alex; https://orcid.org/0000-0002-1967-8255, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, Berger, Christoph; https://orcid.org/0000-0002-2373-8804, Paioni, Paolo; https://orcid.org/0000-0002-3904-1606, Aebi, Christoph; https://orcid.org/0000-0003-3554-7949, Bielicki, Julia; https://orcid.org/0000-0002-3902-5489, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Crisinel, Pierre Alex; https://orcid.org/0000-0002-1967-8255, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, and Berger, Christoph; https://orcid.org/0000-0002-2373-8804

Abstract

Infection following surgical procedures leads to significant morbidity and mortality in all age groups. Sterile techniques, antibiotic prophylaxis and improved postoperative wound care have contributed to the decline of surgical site infections since the early days of surgery. Recommendations on the use of perioperative antimicrobial prophylaxis exist for adults, but are rare for the paediatric population. Here, we provide a standardised approach to the effective use of antimicrobial agents for the prevention of surgical site infections in children contributing to a targeted and rational perioperative use of antibiotics in Switzerland.

Published
2022

20. Swiss recommendations on perioperative antimicrobial prophylaxis in children

Author

Paioni, Paolo, Aebi, Christoph, Bielicki, Julia, Buettcher, Michael, Crisinel, Pierre Alex, Kahlert, Christian R, Wagner, Noémie, Berger, Christoph, Paediatric Infectious Disease Group of Switzerland (PIGS), and University of Zurich

Subjects
History, Sociology and Political Science, General Mathematics, 610 Medicine & health, 2700 General Medicine, Anti-Bacterial Agents/therapeutic use, Anti-Infective Agents/therapeutic use, Antibiotic Prophylaxis/methods, Child, Humans, Surgical Wound Infection/epidemiology, Surgical Wound Infection/prevention & control, Switzerland, Anti-Infective Agents, Surgical Wound Infection, General Materials Science, General Environmental Science, Planning and Development, Multidisciplinary, Geography, Communication, Econometrics and Finance, Mechanical Engineering, General Medicine, General Chemistry, Antibiotic Prophylaxis, General Economics, Anti-Bacterial Agents, 10036 Medical Clinic, Political Science and International Relations, General Earth and Planetary Sciences
Abstract

Infection following surgical procedures leads to significant morbidity and mortality in all age groups. Sterile techniques, antibiotic prophylaxis and improved postoperative wound care have contributed to the decline of surgical site infections since the early days of surgery. Recommendations on the use of perioperative antimicrobial prophylaxis exist for adults, but are rare for the paediatric population. Here, we provide a standardised approach to the effective use of antimicrobial agents for the prevention of surgical site infections in children contributing to a targeted and rational perioperative use of antibiotics in Switzerland.

Published
2022
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23. Ensuring Sufficient Trough Plasma Concentrations for Broad-Spectrum Beta-Lactam Antibiotics in Children With Malignancies: Beware of Augmented Renal Clearance!

Author

André, Pascal, primary, Diezi, Léonore, additional, Dao, Kim, additional, Crisinel, Pierre Alex, additional, Rothuizen, Laura E., additional, Chtioui, Haithem, additional, Decosterd, Laurent Arthur, additional, Diezi, Manuel, additional, Asner, Sandra, additional, and Buclin, Thierry, additional

Published
2022
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24. Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study.

Author

Aebi-Popp, Karoline, Kahlert, Christian R, Crisinel, Pierre-Alex, Decosterd, Laurent, Saldanha, Susana Alves, Hoesli, Irene, Tejada, Begona Martinez De, Duppenthaler, Andrea, Rauch, Andri, Marzolini, Catia, (SHCS), Swiss Mother and Child HIV Cohort Study, Martinez De Tejada, Begona, and Swiss Mother and Child HIV Cohort Study (SHCS)

Subjects
ANTI-HIV agents, MOTHERS, BREAST milk, BLOOD plasma, ANTIRETROVIRAL agents, BREASTFEEDING, RITONAVIR, QUESTIONNAIRES, RESEARCH funding, SWISS, LONGITUDINAL method
Abstract

Introduction: In 2018, Switzerland changed its guidelines to support women living with HIV wishing to breastfeed. The exposure of antiretroviral drugs (ARVs) in breastmilk and the ingested daily dose by the breastfed infant are understudied, notably for newer ARVs. This study aimed to quantify ARV concentrations in maternal plasma and breastmilk to determine the milk/plasma ratio, to estimate daily infant ARV dose from breastfeeding and to measure ARV concentrations in infants.Methods: All women wishing to breastfeed were included, regardless of their ARV treatment. Breastmilk and maternal plasma samples were mostly collected at mid-dosing interval.Results: Twenty-one mother/child pairs were enrolled; of those several were on newer ARVs including 10 raltegravir, 1 bictegravir, 2 rilpivirine, 2 darunavir/ritonavir and 3 tenofovir alafenamide. No vertical HIV transmission was detected (one infant still breastfed). The median milk/plasma ratios were 0.96/0.39 for raltegravir once/twice daily, 0.01 for bictegravir, 1.08 for rilpivirine, 0.12 for darunavir/ritonavir and 4.09 for tenofovir alafenamide. The median estimated infant daily dose (mg/kg) from breastfeeding was 0.02/0.25 for raltegravir once/twice daily, 0.01 for bictegravir, 0.02 for rilpivirine, 0.05 for darunavir/ritonavir and 0.007 for tenofovir alafenamide, resulting in relative infant dose <10% exposure index for all ARVs.Conclusions: ARVs were transferred to a variable extent in breastmilk. Nevertheless, the estimated daily ARV dose from breastfeeding remained low. Differential ARV exposure was observed in breastfed infants with some ARVs being below/above their effective concentrations raising the concern of resistance development if HIV infection occurs. More data on this potential risk are warranted to better support breastfeeding. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Allaitement des femmes vivant avec le VIH : sommes-nous prêts à ouvrir la discussion ?

Author

Wagner, Noémie, Crisinel, Pierre-Alex, Kahlert, Christian, and Martinez De Tejada Weber, Begona

Subjects
Anti-HIV Agents / therapeutic use, ddc:618, Pregnancy Complications, Infectious / diagnosis, HIV Infections / drug therapy, Switzerland / epidemiology, HIV Infections / prevention & control, Breast Feeding / adverse effects, HIV Infections / transmission, Pregnancy, HIV Infections / diagnosis, Humans, Female, Infectious Disease Transmission, Vertical / prevention & control, Mothers / statistics & numerical data, Pregnancy Complications, Infectious / drug therapy
Abstract

La transmission verticale du VIH est presque inexistante en Suisse aujourd'hui. Ce succès a été obtenu grâce au dépistage systématique du VIH de la femme enceinte et aux traitements antirétroviraux, à la césarienne élective (CS), à la prophylaxie postexpositionnelle néonatale (PPEn) et à l'évitement de l'allaitement. La CS et la PPEn ne sont plus recommandées en cas de charge virale indétectable. Des études récentes ont montré que le risque de transmission du VIH par l'allaitement est extrêmement faible, voire nul, lorsque la mère est correctement traitée et suivie. Il est temps de peser les risques et les bénéfices de l'allaitement maternel avec les femmes enceintes infectées par le VIH dans un processus de décision partagée, comme le suggèrent les nouvelles recommandations suisses. En cas d'allaitement, un suivi étroit est incontournable.

Published
2020

33. Toxoplasmose et cytomégalovirus congénitaux en Suisse en 2019

Author

L'Huillier, Arnaud and Crisinel, Pierre Alex

Subjects
ddc:618, Early Diagnosis, Neonatal Screening, Cytomegalovirus Infections / epidemiology, Cytomegalovirus Infections / drug therapy, Infant, Newborn, Toxoplasmosis, Congenital / epidemiology, Humans, Toxoplasmosis, Congenital / diagnosis, Toxoplasmosis, Congenital / drug therapy, Cytomegalovirus Infections / congenital, Switzerland / epidemiology, Cytomegalovirus Infections / diagnosis
Abstract

Epidemiological trends in congenital toxoplasmosis and CMV are extremely divergent. While there were only 39 cases of congenital toxoplasmosis in Switzerland between 1982 and 2015, there was an equivalent number of cases of congenital CMV, 38 in total, in 2017 alone. Serological screening for toxoplasmosis was logically abandoned in Switzerland in 2008. Regarding CMV, there is no recommendation for serological screening or neonatal screening in Switzerland, whereas early diagnosis can improve prognosis through the rapid initiation of antiviral treatment. The epidemiological data generated by sentinel surveillance of congenital CMV infections in Switzerland may or may not justify such a measure in our country in the future. Les évolutions épidémiologiques de la toxoplasmose et du cytomégalovirus (CMV) congénitaux sont extrêmement divergentes. Alors qu'on a recensé seulement 39 cas de toxoplasmose congénitale en Suisse entre 1982 et 2015, on a comptabilisé un nombre équivalent de cas de CMV congénital, 38 au total, pendant la seule année 2017. Le dépistage sérologique de la toxoplasmose a été logiquement abandonné en Suisse à partir de 2008. En ce qui concerne le CMV, il n'existe pas de recommandation de dépistage néonatal en Suisse, alors qu'un diagnostic précoce peut améliorer le pronostic par l'instauration rapide d'un traitement antiviral. Les données épidémiologiques générées par la surveillance sentinelle des infections congénitales à CMV en Suisse devraient permettre de justifier ou non une telle mesure dans notre pays à l'avenir.

Published
2020

37. Single doses of diphtheria-tetanus-pertussis and poliomyelitis vaccines are sufficient to generate a booster-type response to tetanus in most migrant children

Author

Fougère, Yves, primary, El Houss, Samir, additional, Suris, Joan-Carles, additional, Rouvenaz-Defago, Sylvie, additional, Miletto, Damien, additional, Von der Weid, Lucie, additional, Willen, Fanny, additional, Williams-Smith, Joanne Anesta, additional, Gehri, Mario, additional, and Crisinel, Pierre Alex, additional

Published
2019
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39. High coverage of hepatitis B vaccination and low prevalence of chronic hepatitis B in migrant children dictate a new catch-up vaccination strategy

Author

Fougère, Yves, primary, El Houss, Samir, additional, Suris, Joan-Carles, additional, Rouvenaz-Defago, Sylvie, additional, Miletto, Damien, additional, Von der Weid, Lucie, additional, Willen, Fanny, additional, Williams-Smith, Joanne Anesta, additional, Gehri, Mario, additional, and Crisinel, Pierre Alex, additional

Published
2018
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41. Comparison of clinical presentation of respiratory tract infections in H1N1/09-positive and H1N1/09-negative patients

Author

Crisinel, Pierre-Alex, Barazzone, Constance, Kaiser, Laurent, L'Huillier, Arnaud, Taguebue, Jean, Wagner, Noémie, Delcò, Cristina, Siegrist, Claire-Anne, Posfay-Barbe, Klara, Crisinel, Pierre-Alex, Barazzone, Constance, Kaiser, Laurent, L'Huillier, Arnaud, Taguebue, Jean, Wagner, Noémie, Delcò, Cristina, Siegrist, Claire-Anne, and Posfay-Barbe, Klara

Abstract

The true burden of influenza in children is difficult to assess and is probably underestimated as clinical signs are usually nonspecific, and formal viral identification is rarely searched. In this study, we compare the clinical features of infections related to the new H1N1/09 influenza virus with infections due to other respiratory viruses in children consulting in a tertiary care pediatric hospital in Geneva. Between October 1, 2009 and February 10, 2010, 109 patients were recruited, with a median of age of 7years (range 0.1-18). There were 75 H1N1/09-positive patients (69%), and 32 (43%) had identified risk factors such as asthma or a history of wheezing. Fever (87%), cough (92%), and rhinitis (85%) were the most frequent reported presenting symptoms in both patient groups. H1N1/09-positive patients were significantly older (median of 8.2 vs. 4.6years) and were more likely to have risk factors (43% vs. 24%) and myalgias (41% vs. 20%). H1N1/09-negative patients had more wheezing episodes (29% vs. 9%), higher rates of dyspnea (28% vs. 20%) and of hospital admissions (35% vs. 16%). Conclusion: Clinical signs cannot reliably differentiate H1N1/09-positive and H1N1/09-negative patients, although we found a higher proportion of myalgias in H1N1/09-positive patients. Severity of disease was lower in H1N1/09-positive than in H1N1/09-negative patients, mostly because of a higher proportion of asthma/wheezing episodes among H1N1/09-negative patients

Published
2018

43. Attitudes of Swiss Health Care Providers Toward Childhood Immunizations

Author

Schuler, Marianne, primary, Schaedelin, Sabine, additional, Aebi, Christoph, additional, Berger, Christoph, additional, Crisinel, Pierre-Alex, additional, Diana, Alessandro, additional, Niederer-Loher, Anita, additional, Siegrist, Claire-Anne, additional, Vaudaux, Bernard, additional, and Heininger, Ulrich, additional

Published
2017
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44. Bilateral Dacryoadenitis

Author

Ruman-Colombier, Marta, primary, Crisinel, Pierre-Alex, additional, Cohen-Dumani, Nadine, additional, Ceschi, Giorgio, additional, and Rochat Guignard, Isabelle, additional

Published
2017
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46. Déterminants de l'immunité au vaccin de l'Hépatite A dans la cohorte suisse d'enfants infectés par le Virus d'Immunodéficience Humaine

Author

Crisinel, Pierre-Alex and Siegrist, Claire-Anne

Subjects
Enfants, ddc:618, Vaccin, VIH, ddc:616.07, Hépatite A
Abstract

L'objectif de cette étude était d'étudier prospectivement les déterminants de la réponse à la vaccination contre l'hépatite A chez les enfants VIH positifs faisant partie de la cohorte VIH suisse mère enfant. La vaccination a été proposée selon l'immunité au début de l'étude et l'anamnèse vaccinale. Une sérologie initiale a été effectuée chez 87 patients (âge médian 11 ans, extrêmes 3,4 – 21,2) entre juin 2006 et août 2007. Cinquante-cinq patients (51.7%) étaient séronégatifs pour l'hépatite A. Le taux de séroconversion s'élevait à 86% (25/29) après 1 dose et 97% (38/39) après 2 doses de vaccin (moyenne géométrique d'anticorps de 962 mIU/ml). Le taux de lymphocytes T CD4 est le seul paramètre à influencer significativement la réponse secondaire. Le monitoring des concentrations d'anticorps devrait être effectué si les lymphocytes T CD4 sont diminués en dessous de 750/mm3 afin de déterminer si des doses de vaccin supplémentaires sont nécessaires.

Published
2012

47. Infections invasives à méningocoque de groupe B: un problème de santé publique non résolu

Author

Crisinel, Pierre-Alex and Posfay Barbe, Klara

Subjects
ddc:618, Meningitis, Meningococcal/immunology/prevention & control, Switzerland/epidemiology, Meningococcal Infections/epidemiology/immunology/microbiology/prevention & control, Humans, Neisseria meningitidis, Serogroup B/isolation & purification/pathogenicity, Public Health, Meningococcal Vaccines/administration & dosage/adverse effects
Abstract

Group B meningococcal infections represent 64% of the invasive meningococcal infections in Switzerland. While conjugate vaccine against group C meningococcus is part of the additional vaccinations of the Swiss vaccinal calendar and quadrivalent vaccines protect against serogroups A, C, Y, and W135, there is presently no available vaccine against group B meningococcus in Switzerland. The use of the capsular polysaccharide from the group B meningococcus is ineffective and possibly dangerous because of its similarity with an adhesion molecule of the human neuronal cells. Development of new vaccines with other antigenic targets gives hope for an optimal protection not only against group B meningococcus, but also against other serogroups that share same antigenic determinants.

Published
2011

48. Risk of cytomegalovirus infection and disease after umbilical cord blood transplantation in children.

Author

Crisinel, Pierre Alex, Duval, Michel, Crisinel, Delphine Thuillard, Mallette, Brigitte, Bellier, Nathalie, Vachon, Marie-France, Dedeken, Laurence, Rousseau, Céline, Tapiero, Bruce, Ovetchkine, Philippe, Crisinel, Pierre Alex, Duval, Michel, Crisinel, Delphine Thuillard, Mallette, Brigitte, Bellier, Nathalie, Vachon, Marie-France, Dedeken, Laurence, Rousseau, Céline, Tapiero, Bruce, and Ovetchkine, Philippe

Abstract

Pediatric data regarding cytomegalovirus (CMV) infections in pediatric patients receiving umbilical cord blood (UCB) transplantation are sparse., info:eu-repo/semantics/published

Published
2013

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