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1. Orthogonal Covalent Entrapment of Cargo into Biodegradable Polymeric Micelles via Native Chemical Ligation

Author

Erik R. Hebels, Felix Bindt, Johanna Walther, Michiel van Geijn, Jimmy Weterings, Qizhi Hu, Claudio Colombo, Rob Liskamp, Cristianne Rijcken, Wim E. Hennink, and Tina Vermonden

Subjects
Biomaterials, Polymers and Plastics, Materials Chemistry, Bioengineering
Abstract

Polymeric micelles (PMs) are promising platforms for enhanced tissue targeting of entrapped therapeutic agents. Strategies to circumvent premature release of entrapped drugs include cross-linking of the micellar core as well as covalent attachment of the drug cargo. The chemistry employed to obtain cross-linked micelles needs to be mild to also allow entrapment of fragile molecules, such as certain peptides, proteins, oligonucleotides, and fluorescent dyes. Native chemical ligation (NCL) is a mild bio-orthogonal reaction between a

Published
2022

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