9 results on '"Cristina Sarria"'
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2. Dalbavancin in the treatment of different gram-positive infections: a real-life experience
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Emilio Bouza, Maricela Valerio, Alex Soriano, Laura Morata, Enrique García Carus, Carmen Rodríguez-González, Ma Carmen Hidalgo-Tenorio, Antonio Plata, Patricia Muñoz, Antonio Vena, Ana Alvarez-Uria, Ana Fernández-Cruz, Ascensión Arroyo Nieto, Arturo Artero, José María Barbero Allende, Enrique Bernal Morell, Francisco Javier Candel-González, Laura Castelo, Javier Cobo, Maria del Carmen Gálvez Contreras, Roberto Güerri Fernández, Juan Pablo Horcajada, Pablo Guisado-Vasco, Juan Emilio Losa, Rafael Hervás, Simona Mihaela Iftimie, Manuel Enrique Jiménez Mejías, Francisco Jover, José Luis Lamas Ferreiro, Ana B. Lozano Serrano, Eduardo Malmierca, Mar Masiá, Maria Rosa Oltra Sempere, Alicia Rico Nieto, Dolors Rodriguez-Pardo, Sergio J. Rodriguez Alvarez, Rafael San Juan, Cristina Sarria Cepeda, María Antonia Sepúlveda Berrocal, Beatriz Sobrino, and Luisa Sorlí
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0301 basic medicine ,Microbiology (medical) ,Male ,Methicillin-Resistant Staphylococcus aureus ,medicine.medical_specialty ,Prosthesis-Related Infections ,Lipoglycopeptide ,medicine.drug_class ,Gram-positive infection ,Cost-Benefit Analysis ,030106 microbiology ,Antibiotics ,Microbial Sensitivity Tests ,Skin and soft-tissue infection ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Adverse effect ,Aged ,Retrospective Studies ,business.industry ,Osteomyelitis ,Soft Tissue Infections ,Dalbavancin ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Anti-Bacterial Agents ,Infectious Diseases ,Tolerability ,chemistry ,Spain ,Concomitant ,Catheter-Related Infections ,Female ,Staphylococcal Skin Infections ,Teicoplanin ,business ,Enterococcus - Abstract
Dalbavancin is a lipoglycopeptide with a very prolonged half-life enabling treatment with a single intravenous administration that has been approved to treat complicated skin and soft-tissue infections. Information on the efficacy and safety of dalbavancin in other situations is very scarce. This retrospective study included adult patients who received at least one dose of dalbavancin between 2016 and 2017 in 29 institutions in Spain. The primary objective was to report the use of dalbavancin in clinical practice, including its efficacy and tolerability. The potential impact of dalbavancin on reducing the length of hospital stay and hospital costs was also evaluated. A total of 69 patients received dalbavancin during the study period (58.0% male; median age 63.5 years). Dalbavancin was used to treat prosthetic joint infection (29.0%), acute bacterial skin and skin-structure infection (21.7%), osteomyelitis (17.4%) and catheter-related bacteraemia (11.6%). These infections were mainly caused by Staphylococcus aureus (27 isolates), coagulase-negative staphylococci (24 isolates) and Enterococcus spp. (11 isolates). All but two patients received previous antibiotics for a median of 18 days. Dalbavancin was administered for a median of 21 days (range 7-168 days), and concomitant antimicrobial therapy was prescribed to 25 patients (36.2%). The overall clinical success rate of dalbavancin was 84.1%. Adverse events, mainly mild in intensity, were reported in nine patients. Overall, dalbavancin was estimated to reduce hospitalisation by 1160 days, with an estimated overall cost reduction of €211 481 (€3064 per patient). Dalbavancin appears to be an effective therapy for many serious Gram-positive infections.
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- 2017
3. Dalbavancin in the treatment of different gram-positive infections: a real-life experience
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Bouza, Emilio, primary, Valerio, Maricela, additional, Soriano, Alex, additional, Morata, Laura, additional, Carus, Enrique García, additional, Rodríguez-González, Carmen, additional, Hidalgo-Tenorio, Ma Carmen, additional, Plata, Antonio, additional, Muñoz, Patricia, additional, Vena, Antonio, additional, Alvarez-Uria, Ana, additional, Fernández-Cruz, Ana, additional, Nieto, Ascensión Arroyo, additional, Artero, Arturo, additional, Allende, José María Barbero, additional, Morell, Enrique Bernal, additional, Candel-González, Francisco Javier, additional, Castelo, Laura, additional, Cobo, Javier, additional, del Carmen Gálvez Contreras, Maria, additional, Fernández, Roberto Güerri, additional, Horcajada, Juan Pablo, additional, Guisado-Vasco, Pablo, additional, Losa, Juan Emilio, additional, Hervás, Rafael, additional, Iftimie, Simona Mihaela, additional, Mejías, Manuel Enrique Jiménez, additional, Jover, Francisco, additional, Ferreiro, José Luis Lamas, additional, Serrano, Ana B. Lozano, additional, Malmierca, Eduardo, additional, Masiá, Mar, additional, Sempere, Maria Rosa Oltra, additional, Nieto, Alicia Rico, additional, Rodriguez-Pardo, Dolors, additional, Alvarez, Sergio J. Rodriguez, additional, San Juan, Rafael, additional, Cepeda, Cristina Sarria, additional, Berrocal, María Antonia Sepúlveda, additional, Sobrino, Beatriz, additional, and Sorlí, Luisa, additional
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- 2018
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4. Cytokine profiles linked to fatal outcome in infective prosthetic valve endocarditis
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María Heredia, Eva Maria Aguilar‐Blanco, Adolfo Arévalo, Verónica Iglesias, Lucia Rico, Raquel Almansa, Eduardo Tamayo, Juan Bustamante, Cristina Sarria, and Jesus F. Bermejo-Martin
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Male ,Microbiology (medical) ,medicine.medical_specialty ,Late Prosthetic Valve Endocarditis ,Disease ,Pathology and Forensic Medicine ,Interferon-gamma ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Endocarditis ,Interferon gamma ,Aged ,Aged, 80 and over ,Receiver operating characteristic ,Interleukin-6 ,business.industry ,Mortality rate ,Interleukin-8 ,Area under the curve ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Surgery ,ROC Curve ,Spain ,Heart Valve Prosthesis ,Infective endocarditis ,Cytokines ,Female ,business ,Biomarkers ,medicine.drug - Abstract
Infective endocarditis is a disease normally of bacterial cause which affects the endocardic tissue, specifically the valves (native or prosthetic). It is a serious illness and mortality rates remain high, ranging between 20% and 40%. Previous reports have evidenced the potential role of cytokines in the diagnosis of this disease, but no information is available on their relationship with outcome. We recruited 26 consecutive patients with late prosthetic valve endocarditis requiring surgical treatment according to Duke criteria. Eight cytokines were measured in plasma in the first 24 h following diagnosis by using a Bio-Rad multiplex assay. Levels of IL-6, IL-8 and interferon gamma (IFN-γ) were higher in non survivors. Receiver operating characteristic curve analysis evidenced that IL-6, IL-8 and IFN-γ behaved as good diagnostic tests for identifying those patients with fatal outcome (area under the curve, CI 95%, p): IL-6: [0.81 (0.61-1.00) 0.012]; IL-8 [0.76 (0.56-0.96) 0.035]; IFN-γ [0.79 (0.59-0.99) 0.021]. Levels of IL-6, IL-8 and IFN-γ correlated positively between them, indicating that they are produced as consequence of a simultaneous response to the infection. Our findings support the participation of IL-6, IL-8 and IFN-γ in the events linked to fatal outcome in infective prosthetic valve endocarditis.
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- 2013
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5. Short-course antibiotic regimen compared to conventional antibiotic treatment for gram-positive cocci infective endocarditis: randomized clinical trial (SATIE)
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Carmen Olmos, Isidre Vilacosta, Javier López, Carmen Sáez, Manuel Anguita, Pablo Elpidio García-Granja, Cristina Sarriá, Jacobo Silva, Belén Álvarez-Álvarez, María Amparo Martínez-Monzonis, Juan Carlos Castillo, José Seijas, Amanda López-Picado, Vicente Peral, Luis Maroto, and J. Alberto San Román
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Infective endocarditis ,Short-course ,Antibiotic therapy ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Most serious complications of infective endocarditis (IE) appear in the so-called “critical phase” of the disease, which represents the first days after diagnosis. The majority of patients overcoming the acute phase has a favorable outcome, yet they remain hospitalized for a long period of time mainly to complete antibiotic therapy. The major hypothesis of this trial is that in patients with clinically stable IE and adequate response to antibiotic treatment, without signs of persistent infection, periannular complications or metastatic foci, a shorter antibiotic time period would be as efficient and safe as the classic 4 to 6 weeks antibiotic regimen. Methods Multicenter, prospective, randomized, controlled open-label, phase IV clinical trial with a non-inferiority design to evaluate the efficacy of a short course (2 weeks) of parenteral antibiotic therapy compared with conventional antibiotic therapy (4–6 weeks). Sample: patients with IE caused by gram-positive cocci, having received at least 10 days of conventional antibiotic treatment, and at least 7 days after surgery when indicated, without clinical, analytical, microbiological or echocardiographic signs of persistent infection. Estimated sample size: 298 patients. Intervention: Control group: standard duration antibiotic therapy, (4 to 6 weeks) according to ESC guidelines recommendations. Experimental group: short-course antibiotic therapy for 2 weeks. The incidence of the primary composite endpoint of all-cause mortality, unplanned cardiac surgery, symptomatic embolisms and relapses within 6 months after the inclusion in the study will be prospectively registered and compared. Conclusions SATIE will investigate whether a two weeks short-course of intravenous antibiotics in patients with IE caused by gram-positive cocci, without signs of persistent infection, is not inferior in safety and efficacy to conventional antibiotic treatment (4–6 weeks). Trial registration ClinicalTrials.gov Identifier: NCT04222257 (January 7, 2020). EudraCT 2019–003358-10.
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- 2020
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6. Revisores de la edición española
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Aguado, Carlos Barros, Cabrera, José Antonio de Diego, Sebastián, Jesús Díez, Núñez, Fernando Dronda, Carbonero, Luz Martín, Martínez, Pedro del Río, Rodríguez-Avial, Carmen, Cabrera, Juan Pedro Romanyk, Cepeda, Cristina Sarriá, Revuelta, José Ramón Toral, and García, Jorge Vergas
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- 2021
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7. Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions
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Evangelia-Georgia Kostaki, Andreas Flampouris, Timokratis Karamitros, Natalia Chueca, Marta Alvarez, Paz Casas, Belen Alejos, Angelos Hatzakis, Federico Garcia, Dimitrios Paraskevis, CoRIS, Santiago Moreno, Inma Jarrín, David Dalmau, Maria Luisa Navarro, Maria Isabel González, Jose Luis Blanco, Rafael Rubio, Jose Antonio Iribarren, Félix Gutiérrez, Francesc Vidal, Juan Berenguer, Juan González, Belén Alejos, Victoria Hernando, Cristina Moreno, Carlos Iniesta, Luis Miguel Garcia Sousa, Nieves Sanz Perez, M Ángeles Muñoz-Fernández, Isabel María García-Merino, Irene Consuegra Fernández, Coral Gómez Rico, Jorge Gallego de la Fuente, Paula Palau Concejo, Joaquín Portilla, Esperanza Merino, Sergio Reus, Vicente Boix, Livia Giner, Carmen Gadea, Irene Portilla, María Pampliega, Marcos Díez, Juan Carlos Rodríguez, José Sánchez-Payá, Juan Luis Gómez, Jehovana Hernández, María Remedios Alemán, María del Mar Alonso, María Inmaculada Hernández, Felicitas Díaz-Flores, Dácil García, Ricardo Pelazas, Ana López Lirola, José Sanz Moreno, Alberto Arranz Caso, Cristina Hernández Gutiérrez, María Novella Mena, Federico Pulido, Otilia Bisbal, Asunción Hernando, Lourdes Domínguez, David Rial Crestelo, Laura Bermejo, Mireia Santacreu, José Antonio Iribarren, Julio Arrizabalaga, María José Aramburu, Xabier Camino, Francisco Rodríguez-Arrondo, Miguel Ángel von Wichmann, Lidia Pascual Tomé, Miguel Ángel Goenaga, Ma Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Aitziber Lizardi, Xabier Kortajarena, Mar Masiá, Sergio Padilla, Andrés Navarro, Fernando Montolio, Catalina Robledano, Joan Gregori Colomé, Araceli Adsuar, Rafael Pascual, Marta Fernández, Elena García, José Alberto García, Xavier Barber, Juan Carlos López Bernaldo de Quirós, Isabel Gutiérrez, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldamiz-Echevarría, Francisco Tejerina, Francisco José Parras, Pascual Balsalobre, Cristina Diez, Leire Pérez Latorre, Joaquín Peraire, Consuelo Viladés, Sergio Veloso, Montserrat Vargas, Miguel López-Dupla, Montserrat Olona, Anna Rull, Esther Rodríguez-Gallego, Verónica Alba, Marta Montero Alonso, José López Aldeguer, Marino Blanes Juliá, María Tasias Pitarch, Iván Castro Hernández, Eva Calabuig Muñoz, Sandra Cuéllar Tovar, Miguel Salavert Lletí, Juan Fernández Navarro, Jose Miguel Molina, Juan González-garcia, Francisco Arnalich, José Ramón Arribas, Jose Ignacio Bernardino de la Serna, Juan Miguel Castro, Luis Escosa, Pedro Herranz, Victor Hontañón, Silvia García-Bujalance, Milagros García López-Hortelano, Alicia González-Baeza, Maria Luz Martín-Carbonero, Mario Mayoral, Maria Jose Mellado, Rafael Esteban Micán, Rocio Montejano, María Luisa Montes, Victoria Moreno, Ignacio Pérez-Valero, Berta Rodés, Talia Sainz, Elena Sendagorta, Natalia Stella Alcáriz, Eulalia Valencia, José Ramón Blanco, José Antonio Oteo, Valvanera Ibarra, Luis Metola, Mercedes Sanz, Laura Pérez-Martínez, Angels Jaén, Montse Sanmartí, Mireia Cairó, Javier Martinez-Lacasa, Pablo Velli, Roser Font, Mariona Xercavins, Noemí Alonso, Jesús Repáraz, María Gracia Ruiz de Alda, María Teresa de León Cano, Beatriz Pierola Ruiz de Galarreta, Ignacio de los Santos, Jesús Sanz Sanz, Ana Salas Aparicio, Cristina Sarriá Cepeda, Lucio Garcia-Fraile Fraile, Enrique Martín Gayo, José Luis Casado, Fernando Dronda, Ana Moreno, María Jesús Pérez Elías, Cristina Gómez Ayerbe, Carolina Gutiérrez, Nadia Madrid, Santos del Campo Terrón, Paloma Martí, Uxua Ansa, Sergio Serrano, María Jesús Vivancos, Enrique Bernal, Alfredo Cano, Antonia Alcaraz García, Joaquín Bravo Urbieta, Ángeles Muñoz, Maria Jose Alcaraz, Maria del Carmen Villalba, Federico García, José Hernández, Alejandro Peña, Leopoldo Muñoz, David Vinuesa, Clara Martinez-Montes, Fernando García, Carlos Guerrero-Beltran, Jorge Del Romero, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Antonio Antela, Elena Losada, Antonio Aguilera, Melchor Riera, María Peñaranda, María Leyes, Ma Angels Ribas, Antoni A Campins, Carmen Vidal, Francisco Fanjul, Javier Murillas, Francisco Homar, Jesús Santos, Crisitina Gómez Ayerbe, Isabel Viciana, Rosario Palacios, Carmen María González, Pompeyo Viciana, Nuria Espinosa, Luis Fernando López-Cortés, Daniel Podzamczer, Elena Ferrer, Arkaitz Imaz, Juan Tiraboschi, Ana Silva, María Saumoy, Julián Olalla, Alfonso del Arco, Javier de la torre, José Luis Prada, José María García de Lomas Guerrero, Javier Pérez Stachowski, Concepción Amador, Onofre Juan Martínez, Francisco Jesús Vera, Lorena Martínez, Josefina García, Begoña Alcaraz, Amaya Jimeno, Angeles Castro Iglesias, Berta Pernas Souto, Alvaro Mena de Cea, Carlos Galera, Helena Albendin, Aurora Pérez, Asunción Iborra, Antonio Moreno, Maria Angustias Merlos, Asunción Vidal, Inés Suárez-García, Eduardo Malmierca, Patricia González-Ruano, Dolores Martín Rodrigo, Mohamed Omar Mohamed-Balghata, Juan A Pineda, Juan Macías, Miguel Thomson, Elena Delgado, Sonia Benito, and Vanessa Montero
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HIV-1 ,CRF02_AG ,Spain ,regional dispersal ,spatiotemporal characteristics ,Microbiology ,QR1-502 - Abstract
Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics.
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- 2019
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8. Actualización en endocarditis protésica
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Carmen Olmos, Isidre Vilacosta, Javier López, Cristina Sarriá, Carlos Ferrera, and José A. San Román
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Endocarditis protésica ,Cirugía ,Pronóstico ,Ecocardiografía ,Tomografía computarizada/tomografía por emisión de positrones ,Medicine ,Surgery ,RD1-811 - Abstract
La endocarditis infecciosa (EI) sobre prótesis valvulares (EIPV) es una de las formas más graves de esta enfermedad y se asocia con elevada mortalidad intrahospitalaria y necesidad de cirugía. Todo paciente con EIPV debe ser atendido en centros hospitalarios de referencia en endocarditis, en los que exista un equipo de endocarditis muldisciplinar que incluya a cardiólogos clínicos y expertos en imagen cardiaca, cirujanos cardiacos, microbiólogos y especialistas en enfermedades infecciosas con experiencia en EI. En este trabajo se revisan los aspectos diagnósticos, terapéuticos y pronósticos de esta entidad.
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- 2017
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9. Diseño e Implementación de Manual de Procedimientos para los Análisis Físicos y Sensoriales del Laboratorio de Catación de Café del Centro Agroindustrial Sena Regional Quindío
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Pinzón Aguirre, María, Paula and Universidad del Quindío - Colombia - Asesor - Isabel Cristina Sarria Tangarife Encargada Laboratorio de Catación de café SENA-Centro Agroindustrial Regional Quindío
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Productores ,Café ,Origen ,Calidad - Abstract
El café de Colombia es una marca reconocida y valorada a nivel mundial por su denominación de origen, esto gracias al esfuerzo de los productores que mantiene la calidad durante toda la cadena productiva. En Colombia la zona cafetera abarca un gran número de departamentos que dan orígenes diferentes por sus condiciones especiales de altitud, latitud, clima, y la calidad de la tierra como atributo fundamental. Los suelos de las zonas cafeteras colombianas se caracterizan por ser en su mayoría derivados de cenizas volcánicas, lo que los dota de un alto contenido de material orgánico y buenas características físicas para la producción de café., 1. Introducción, 2. Objetivos, 3. Antecendentes, 4. Marco teórico, 5. Metodología, 6. Conclusiones, 7. Recomendaciones, 8. Bibliografía, 9. Anexos, Pregrado, Ingeniero de Alimentos
- Published
- 2012
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