1. Sensory gating in young children with autism: Relation to age, IQ, and EEG gamma oscillations
- Author
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Tatiana A. Stroganova, Elena V. Orekhova, Mikael Elam, Cristopher Gillberg, Gudrun Nygren, and Andrey O. Prokofyev
- Subjects
Male ,Sensory processing ,medicine.medical_treatment ,Intelligence ,Gating ,Electroencephalography ,mental disorders ,medicine ,Humans ,Autistic Disorder ,Child ,Sensory gating ,medicine.diagnostic_test ,General Neuroscience ,Age Factors ,medicine.disease ,Hyperacusis ,Electrophysiology ,medicine.anatomical_structure ,Acoustic Stimulation ,El Niño ,Child, Preschool ,Evoked Potentials, Auditory ,Autism ,Female ,Auditory Physiology ,Psychology ,Neuroscience - Abstract
Unusual reactions to auditory stimuli are often observed in autism and may relate to ineffective inhibitory modulation of sensory input (sensory gating). A previous study of P50 sensory gating did not reveal abnormalities in high-functioning school age children [C. Kemner, B. Oranje, M.N. Verbaten, H. van Engeland, Normal P50 gating in children with autism, J. Clin. Psychiatry 63 (2002) 214-217]. Sensory gating deficit may, however, characterize younger children with autism or be a feature of retarded children with autism, reflecting imbalance of neuronal excitation/inhibition in these cohorts. We applied a paired clicks paradigm to study P50 sensory gating, and its relation to IQ and EEG gamma spectral power (as a putative marker of cortical excitability), in young (3-8 years) children with autism (N=21) and age-matched typically developing children (N=21). P50 suppression in response to the second click was normal in high-functioning children with autism, but significantly (p
- Published
- 2008
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