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1. Hypoalbuminemia and Risk of Portal Vein Thrombosis in Cirrhosis

Author

Roberto Cangemi, Valeria Raparelli, Giovanni Talerico, Stefania Basili, Francesco Violi, Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davì Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodríguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Corazza Gino Roberto, Caldwell Stephen Hugh, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Proietti Marco, Raparelli Valeria, Romiti Giulio Francesco, Ruscio Eleonora, Severoni Andrea, Talerico Giovanni, Toriello Filippo, and Vestri Annarita

Subjects
Albumin, Cirrhosis, Portal Vein Thrombosis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and Aims: Hypoalbuminemia, as defined by serum albumin (SA) levels ≤35 g/L, is associated to venous and arterial thrombosis in general population and in patients at risk of cardiovascular disease. It is unknown if SA ≤35 g/L is also associated to portal vein thrombosis (PVT) in cirrhosis. Methods: Cirrhotic patients enrolled in the Portal vein thrombosis Relevance On Liver cirrhosis: Italian Venous thrombotic Events Registry (PRO-LIVER) study (n = 753), were followed-up for 2 years to assess the risk of PVT, that was diagnosed by Doppler ultrasonography. Child-Pugh classes, Model for End-Stage Liver Disease score, presence of hepatocellular carcinoma and laboratory variables including SA, D-dimer, and high-sensitivity C-reactive protein (hs-CRP) were measured at baseline. Results: SA ≤35 g/L was detected in 52% of patients. A logistic multivariate regression analysis showed that higher Child-Pugh class, hepatocellular carcinoma and thrombocytopenia were significantly associated to SA ≤35 g/L. In a subgroup of patients where data regarding hs-CRP and D-dimer were available, SA ≤35 g/L was inversely associated with hs-CRP and D-dimer. During the follow-up, a total of 61 patients experienced PVT. A Kaplan Meier survival analysis showed SA ≤35 g/L was associated to increased risk of PVT compared to SA >35 g/L (P = .005). A multivariate Cox proportional hazards regression analysis showed that male sex, lower platelet count, and SA ≤35 g/L remained associated to PVT after adjusting for confounding factors. Conclusion: Cirrhotic patients with SA ≤35 g/L are at higher risk of experiencing PVT compared to those with SA >35 g/L and could be considered as potential candidates to anticoagulant prophylaxis for PVT prevention.

Published
2024
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3. BCD Process Technologies

Author

Croce, Giuseppe, Andreini, Antonio, Galbiati, Paola, Diazzi, Claudio, Merkle, Dieter, Managing Editor, Rudan, Massimo, editor, Brunetti, Rossella, editor, and Reggiani, Susanna, editor

Published
2023
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5. Transmission Line Pulse (TLP) as integrative method for the investigation of ultra-fast trapping mechanisms on high-k MIM

Author

Merlo, Luca, Rossetto, Isabella, Cerati, Lorenzo, Ghidini, Gabriella, Milani, Antonella, Toia, Fabrizio, Piagge, Rossella, Di Biccari, Leonardo, Gevinti, Eleonora, Croce, Giuseppe, and Andreini, Antonio

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science
Abstract

This paper discusses the transmission line pulse (TLP) analysis, generally used for electrostatic discharge (ESD) device characterization, as high potential usable tool also for non-ESD structures. TLP technique, combined with DC and pulsed I-V characterization, is performed to study the contribution of trap states on current conduction in metal-insulator-metal (MIM) capacitors with an HfAlO stack. The importance of the above mentioned methods is demonstrated by comparing two generations of samples with slightly different charge trapping mechanisms; their impact on the current conduction is furthermore studied by decreasing the pulse width down to 50nsec. TLP analysis is finally discussed as interesting method to investigate the influence of trap states on the device robustness. The evaluation of breakdown voltage for different time pulses allows to discriminate whether different failure mechanisms occur or not and to establish the impact of trap states on short-term reliability., Comment: Uploaded document is a pre-print version, not the final one published on journal. This work was partially supported by ECSEL-JU R2POWER300 project under grant agreement no. 653933

Published
2020
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9. The Role of Public Policy in Worker Training in Italy

Author

Croce, Giuseppe and Montanino, Andrea

Abstract

The training received by workers depends predominantly on the organisational choices and funds allocated by businesses. It is therefore justifiable to ask whether public policy should either endorse the spontaneous distribution of training or take measures to correct it. This paper analyses the motivations and limitations of public intervention, focusing on the Italian case in which, in recent years, the system has changed radically as a result of opportunities offered to social partners to directly administer the financial resources available for continuous training. The paper argues that the policy instruments in Italy are not capable of providing a clear response to the need for the two forms of continuous training--collective and individual. Therefore, the paper proposes that a part of the funds be administered by the social partners specifically to promote collective training, leaving the public administration with the task of responding primarily to the demands expressed by individuals. (Contains 5 footnotes.)

Published
2007

12. Severe reduction of blood lysosomal acid lipase activity in cryptogenic cirrhosis: A nationwide multicentre cohort study

Author

Violi, Francesco, Angelico, Francesco, Pastori, Daniele, Baratta, Francesco, Del Ben, Maria, Polimeni, Licia, Labbadia, Giancarlo, Basili, Stefania, Raparelli, Valeria, Napoleone, Laura, Corradini, Stefano Ginanni, Ferri, Flaminia, Monica, Pellone, Mischitelli, Monica, Lucia, Parlati, Tozzi, Giulia, D'Amico, Jessica, Colzi, Marina, Andreozzi, Paola, Perticone, Francesco, Caroleo, Benedetto, Corazza, Gino Roberto, Michela, Masotti, Gaetano, Bergamaschi, Sacerdoti, David, Brocco, Silvia, Angelico, Mario, Santopaolo, Francesco, Francioso, Simona, Pujatti, Pietro Luigi, Faedo, Alessandra, Andriulli, Angelo, Ippolito, Antonio M., Bolondi, Luigi, Tovoli, Francesco, Fargion, Silvia, Fracanzani, Anna Ludovica, Davì, Giovanni, Di Michele, Dario, Croce, Giuseppe, Averna, Maurizio, Giammanco, Antonina, Persico, Marcello, Bucci, Tommaso, Iuliano, Luigi, and Ciacciarelli, Marco

Published
2017
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14. Educational Mismatch and Spatial Flexibility in Italian Local Labour Markets

Author

Croce, Giuseppe and Ghignoni, Emanuela

Abstract

According to recent literature, this paper highlights the relevance of spatial mobility as an explanatory factor of the individual risk of job-education mismatch. To investigate this causal link, we use individual information about daily home-to-work commuting time and choices to relocate in a different local area to get a job. Our model takes into account relevant local labour market features. We control for selective access to employment and test for endogeneity of spatial mobility. Results show a negative impact of commuting time on educational mismatch for upper-secondary graduates, as well as a negative impact of migration/migration distance for university graduates.

Published
2015
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15. From Survey Results to a Decision-Making Matrix for Strategic Planning in Healthcare: The Case of Clinical Pathways

Author

Bianco, Lavinia, primary, Raffa, Salvatore, additional, Fornelli, Paolo, additional, Mancini, Rita, additional, Gabriele, Angela, additional, Medici, Francesco, additional, Battista, Claudia, additional, Greco, Stefania, additional, Croce, Giuseppe, additional, Germani, Aldo, additional, Petrucci, Simona, additional, Anibaldi, Paolo, additional, Bianco, Valerio, additional, Ronchetti, Mario, additional, Banchieri, Giorgio, additional, Napoli, Christian, additional, and Piane, Maria, additional

Published
2022
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18. Impact of the COVID-19 Pandemic on Clinical Pathways for Non-SARS-CoV-2 Related Diseases in the Lazio Region, Italy

Author

Piane, Maria, primary, Bianco, Lavinia, additional, Mancini, Rita, additional, Fornelli, Paolo, additional, Gabriele, Angela, additional, Medici, Francesco, additional, Battista, Claudia, additional, Greco, Stefania, additional, Croce, Giuseppe, additional, Franceschetti, Laura, additional, Napoli, Christian, additional, Ronchetti, Mario, additional, Anibaldi, Paolo, additional, and Banchieri, Giorgio, additional

Published
2022
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24. La Grèce et le Vatican de 1918 au début des années trente. Projets de Concordat et polémiques interconfessionnelles

Author

Croce, Giuseppe M.

Subjects
History, identité culturelle, HIS010000, civilisation, Moyen-Orient, histoire culturelle, HBJD
Abstract

Puisant dans des archives peu connues du Vatican, ce chapitre porte sur les discussions en coulisses qui se sont déroulées de la fin de la première guerre mondiale jusqu’en 1930, entre les représentants du Saint-Siège et ceux du gouvernement grec. Au début des années 1920, le gouvernement de Vénizélos autorise des discussions avec des agents du Saint-Siège, en vue de signer un concordat qui règlerait la présence de l’Église catholique en Grèce. Bien que les premières discussions donnent des raisons d’être optimiste, les deux partis restent intransigeants sur des questions telles que le mariage mixte et le contrôle papal des nominations. Dans les années qui suivent, l’instabilité politique grecque et les tensions régionales, incluant l’arrivée massive des refugiés grecs venant d’Asie Mineure, interrompent et compliquent les discussions avec le Vatican. À la fin des années 1920, les problèmes internes parmi les Grecs catholiques et au sein du gouvernement grec, ajoutés à la position réprobatrice et agressive de l’Église grecque orthodoxe créent un environnement si hostile que la possibilité d’un accord s’en trouve grandement réduite. Drawing on largely unexamined sources from Vatican archives, this chapter looks at behind the scenes discussions between Vatican and Greek government officials between the end of World War One and 1930. In the early 1920s, the government of Venizelos authorized discussions with Vatican officials with a view to forming a concordat that would legitimize the Catholic Church’s presence in Greece. While early discussions between Vatican and Greek officials gave reason for optimism, both sides were intransigent on issues such as mixed marriages and control of papal appointments. As the 1920s progressed, changing Greek governments and regional tensions, including the expulsion of Greek populations from Asia Minor, interrupted and complicated discussions with the Vatican. The chapter proposes that by the late 1920s, internal problems among Greek Catholics and in the Greek government combined with the Greek Orthodox Church’s combative position created such a hostile environment for discussions that the possibility of reaching an agreement was greatly diminished.

Published
2021

25. Voisinages fragiles

Author

Anagnostopoulou, Sia, Anastassiadis, Anastassios, Andriotis, Nikos, Anne Frantz, Eva, Astafieva, Elena, Bocquet, Jérôme, Cabanel, Patrick, Clayer, Nathalie, Croce, Giuseppe M., Danova, Nadia, Kostis, Kostas, Lyberatos, Andreas, Methodieva, Milena B., Pettinaroli, Laura, Prudhomme, Claude, Sabotič, Ines, Trimbur, Dominique, Verdeil, Chantal, and Anastassiadis, Anastassios

Subjects
History, identité culturelle, HIS010000, civilisation, Moyen-Orient, histoire culturelle, HBJD
Abstract

Voisinages fragiles est le premier résultat d’un effort collectif, toujours en cours, ambitionnant de participer à l’écriture d’une histoire connectée de la Méditerranée orientale aux XIXe et XXe siècles. Cet ouvrage rompt avec les carcans géo-disciplinaires arbitraires qui obligent souvent spécialistes de l’Empire ottoman, du Moyen-Orient et des Balkans à travailler de façon séparée. Il remet également en question la perception de cet espace en termes de cadres identitaires, religieux ou politiques essentialistes et monolithes, en soulignant la valeur heuristique de l’étude des interactions dans toute leur complexité. Notre approche analytique multiscalaire (locale, régionale, nationale, impériale, globale) nous amène à esquisser un premier tableau de la variété des contacts, de la multitude des stratégies des individus comme des institutions, du rapport complexe entre religions, identités et politique. Voisinages fragiles is the first product of an on-going collective effort participating in the wider effort of writing a connected history of the Eastern Mediterranean in the 19th and 20th centuries. This history breaks away from the arbitrary geo-disciplinary yoke of area studies which forces specialists of the Ottoman Empire, the Middle East and the Balkans to work in separate clusters. This history also challenges the perception of this space in terms of essentialist and monolithic religious, political and identity frameworks. It underlines the heuristic value of studying interactions to the fullest extent possible. Our multi-scalar analytical approach (local, regional, national, imperial, global) brings to life a first panorama of the wide variety of contacts, the multitude of individual and institutional strategies, the complex relationship between religions, identities and politics.

Published
2021

30. Demand and supply of skilled labour and overeducation in Europe: a country-level analysis

Author

Croce, Giuseppe and Ghignoni, Emanuela

Subjects
Skilled labor, College graduates -- Forecasts and trends -- Employment, Vocational qualifications -- Analysis, Job qualifications -- Analysis, Business, general, Business, Economics
Abstract

This paper analyses the incidence of overeducation of university graduates. To this end, we estimate a random effects model for a panel of European countries. Our results do not confirm that the increase of the supply of qualified labour per se can be seen as a relevant factor fuelling overeducation. The relative wage of university graduates is inversely related to overeducation. This finding suggests a rote for the demand for qualified Labour. Cyclical conditions also matter, as overeducation operates as a short-term adjustment mechanism. This result sheds new Light on the possible effects of the recession currently hitting the industrialized countries and on policy measures needed to foster economic recovery. Comparative Economic Studies (2012) 54, 413-439. doi:10.1057/ces.2012.12, published online 12 April 2012 Keywords: overeducation, university graduates, skill-biased technical change, output gap, panel data JEL Classifications: I24, I28, J24, INTRODUCTION An imbalance between the demand and supply of educated labour is the most intuitive and captivating explanation for cross-country differences in the incidence of overeducation. According to this view, [...]

Published
2012
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33. Tea, flavonoids, and nitric oxide-mediated vascular reactivity

Author

Grassi, Davide, Aggio, Annalisa, Onori, Luciano, Croce, Giuseppe, Tiberti, Sergio, Ferri, Claudio, Ferri, Livia, and Desideri, Giovambattista

Subjects
Atherosclerosis -- Prevention, Tea -- Usage, Tea -- Health aspects, Tea -- Chemical properties, Bioflavonoids -- Health aspects, Flavones -- Health aspects, Flavonoids -- Health aspects, Food/cooking/nutrition
Abstract

Epidemiological evidence supports the concept that diets rich in fruits and vegetables promote health and attenuate or delay the onset of cardiovascular disease (CVD). Although a variety of factors contribute to the beneficial effects of plant foods, much attention has been addressed to plant polyphenols. In this regard, in the daily Western diet, both black and green teas contribute to a relevant proportion of total phenol intake. The more abundant class of flavonoids that is present in teas is represented by flavanols, i.e., catechin, epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate. Studies using animal models of atherosclerosis indicate that dietary flavonoid consumption delays atherosclerotic plaque development. Accordingly, an inverse association between tea intake and CVD has been demonstrated. Further, flavonoids can reduce endothelial dysfunction, i.e., the key step in the development of atherosclerosis. Concordantly, human data suggest that tea may reduce blood pressure levels. Despite this, although they often show that tea may have cardiovascular protective effects, results from epidemiological studies exploring the association between tea and health are controversial. Conflicting results may be caused by disparate study designs and flavonoid contents in different kinds of tea. Thus, because tea is a popular beverage worldwide, and several studies have shown that it is protective against CVD, further studies are needed to determine the role of tea in primary and secondary cardiovascular prevention.

Published
2008

39. Novel TCAD Approach for the Investigation of Charge Transport in Thick Amorphous SiO 2 Insulators.

Author

Giuliano, Federico, Reggiani, Susanna, Gnani, Elena, Gnudi, Antonio, Rossetti, Mattia, Depetro, Riccardo, and Croce, Giuseppe

Subjects
METAL-insulator-metal structures, SILICON oxide, STRAY currents, SILICA, AMORPHOUS silicon
Abstract

A TCAD approach for the investigation of charge transport in thick amorphous silicon dioxide is presented for the first time. Thick oxides are investigated representing the best candidates for integrated galvanic insulators in future power applications. The large electric fields, such devices experience and the preexisting defects in the amorphous material, give rise to a leakage current, which leads to degradation and failure. Hence, it is crucial to have a complete understanding of the main physical mechanisms responsible for the charge transport in amorphous silicon oxide. For this reason, metal–insulator–metal structures have been experimentally characterized at different high-field stress conditions and a TCAD approach has been implemented in order to gain insight into the microscopic physical mechanisms responsible for the leakage current. In particular, the role of charge injection at contacts and charge build-up due to trapping–detrapping mechanisms in the bulk of the oxide layer has been investigated and modeled to the purpose of understanding the oxide behavior under dc- and ac-stress conditions. Numerical simulations have been compared against experiments to quantitatively validate the proposed approach. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis

Author

Basili, Stefania, Carnevale, Roberto, Nocella, Cristina, Bartimoccia, Simona, Raparelli, Valeria, Talerico, Giovanni, Stefanini, Lucia, Romiti, Giulio F, Perticone, Francesco, Corazza, Gino R, Piscaglia, Fabio, Pietrangelo, Antonello, Violi, Francesco, and PRO-LIVER collaborators, : Ainora Maria Elena, Andreozzi, Paola, Andriulli, Angelo, Angelico, Francesco, Angelico, Mario, Figliomeni, Antonio, Anzaldi, Massimiliano, Arena, Umberto, Averna, Maurizio, Barone, Milena, Bazzini, Cristina, Bergamaschi, Gaetano, Bertoni, Michele, Bianchi Giovanni Battista, Bianchi Paola Ilaria, Boari, Benedetta, Bombonato, Giancarlo, Bracco, Christian, Brocco, Silvia, Buonauro, Agostino, Buttà, Carmelo, Buzzetti, Elena, Cacciola, Irene, Calabria, Stefano, Cangemi, Roberto, Capeci, William, Caradio, Federica, Carderi, Isabella, Carleo, Pietro, Caroleo, Benedetto, Carrabba Maria Domenica, Castorani, Luigi, Cavallo, Maurizio, Cecchetto, Lara, Cesaro, Flavio, Cicco, Sebastiano, Cimini, Claudia, Colombo Barbara Maria, Corradini, Elena, Corrao, Salvatore, Costantino, Giorgio, Costanzo, Filippo, Croce, Giuseppe, Cuoghi, Chiara, Curigliano, Valentina, D’Alitto, Felicia, D’Amico, Gennaro, De Franchis Roberto, De Giorgi Alfredo, De Vuono Stefano, Debernardi Venon Wilma, Del Ben Maria, Del Corso Lisette, Delitala, Giuseppe, Denegri, Andrea, Di Cesare Valentina, Di Giosia Paolo, Di Michele Dario, Di Minno Giovanni, Donnarumma, Emilia, Drenaggi, Davide, Durante-Mangoni, Emanuele, Falsetti, Lorenzo, Farcomeni, Alessio, Farinaro, Vincenza, Fasolato, Silvano, Ferrari, Giovanni, Fierro, Tiziana, Forgione, Alessandra, Frugiuele, Pierluigi, Galati, Giovanni, Gallo, Paolo, Garcovich, Matteo, Gargano, Ruggiero, Gasbarrini, Antonio, Gatta, Angelo, Giammanco, Antonina, Giannelli, Gianluigi, Giorgini, Paolo, Gobbi, Paolo, Granito, Alessandro, Grassi, Davide, Greco, Antonio, Grembiale, Alessandro, Gresele, Paolo, Hijazi, Daniel, Iacobellis, Angelo, Iamele, Luigi, Invernizzi, Pietro, Ippolito, Antonio, Laffi, Giacomo, Licata, Anna, Liguori Maria Livia, Lorusso, Giusi, Maimone, Sergio, Manfredini, Roberto, Marcacci, Matteo, Marchese, Alessandra, Marinelli, Sara, Marra Alberto Maria, Martino Giuseppe Pio, Masala, Maristella, Masotti, Michela, Merla, Antonio, Miceli, Giuseppe, Montebianco Abenavoli Ludovico, Morana, Ignazio, Morelli, Olivia, Murgia, Giuseppe, Naccarato, Paola, Neri, Sergio, Niro, Grazia, Nobili, Lorenzo, Padula, Donatella, Palasciano, Giuseppe, Palmieri Vincenzo Ostilio, Pastori, Daniele, Pattoneri, Paolo, Perego, Francesca, Perticone, Maria, Pesce, Paola, Petramala, Luigi, Pettinari, Irene, Piano, Salvatore, Picardi, Antonio, Pignataro Francesca Serena, Pignataro, Pietro, Pignatelli, Pasquale, Pinna, Miriam, Pinto, Antonio, Pinto, Daniela, Polimeni, Licia, Pretti, Vincenzo, Privitera, Graziella, Proietti, Marco, Pucci, Giacomo, Purrello, Francesco, Ragone, Enrico, Raimondo, Giovanni, Restuccia, Tea, Riccardi, Laura, Rizzetto, Mario, Rodríguez-Castro Kryssia Isabel, Romanelli Roberto Giulio, Ruscio, Eleonora, Sacerdoti, David, Salinaro, Francesco, Salvi, Aldo, Salzano, Andrea, Santangelo, Giuseppe, Santarossa, Claudia, Santilli, Francesca, Santovito, Daniela, Scarpini, Francesca, Schiavone, Cosima, Scicali, Roberto, Senzolo, Marco, Serra, Carla, Serviddio, Gaetano, Sirico, Domenico, Soresi, Maurizio, Sperduti, Nicolò, Staffolani, Silvia, Staltari, Orietta, Stasi, Cristina, Suppressa, Patrizia, Svegliati Baroni Gianluca, Talia, Michela, Tana, Claudio, Tassone Eliezer Joseph, Todisco, Tommaso, Toriello, Filippo, Torres, Daniele, Traversa, Matteo, Tripepi, Giovanni, Tufano, Antonella, Tuttolomondo, Antonino, Varvara, Doriana, Vazzana, Natale, Vecchio Claudia Rita, Vendemiale, Gianluigi, Ventura, Paolo, Vespasiani-Gentilucci, Umberto, Vettore, Elia, Vidili, Gianpaolo, Villani, Rosanna, Vincenzo, Ronca, Visioli, Giacomo, Vitale, Francesco, Zocco Maria, Assunta., and Stefania Basili, Roberto Carnevale, Cristina Nocella, Simona Bartimoccia, Valeria Raparelli, Giovanni Talerico, Lucia Stefanini, Giulio F. Romiti, Francesco Perticone, Gino R. Corazza, Fabio Piscaglia, Antonello Pietrangelo, Francesco Violi, PRO-LIVER Collaborators, Alessandro Granito

Subjects
medicine.medical_specialty, Cirrhosis, Isoprostane, Urinary system, serum albumin, Serum albumin, Gastroenterology, NO, chemistry.chemical_compound, Internal medicine, Medicine, Platelet, portal vein thrombosis, Platelet activation, Portal vein thrombosis, Albumin, risk, protein, albumin, risk, Hepatology, biology, business.industry, cirrhosis, Albumin, Original Articles, medicine.disease, Portal vein thrombosis, chemistry, biology.protein, Original Article, protein, albumin, portal vein thrombosis, cirrhosis, business
Abstract

We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound‐detected PVT were retrospectively analyzed. In part 2, 112 patients with LC and 56 matched controls were entered in the cross‐sectional study. In part 3, 5 patients with cirrhosis were entered in the in vivo study and 4 healthy subjects (HSs) were entered in the in vitro study to explore if albumin may affect platelet activation by modulating oxidative stress. In the 753 patients with LC, the prevalence of PVT was 16.7%; logistic analysis showed that only age (odds ratio [OR], 1.024; P = 0.012) and serum albumin (OR, −0.422; P = 0.0001) significantly predicted patients with PVT. Analyzing the 112 patients with LC and controls, soluble clusters of differentiation (CD)40‐ligand (P = 0.0238), soluble Nox2‐derived peptide (sNox2‐dp; P < 0.0001), and urinary excretion of isoprostanes (P = 0.0078) were higher in patients with LC. In LC, albumin was correlated with sCD40L (Spearman’s rank correlation coefficient [rs], −0.33; P < 0.001), sNox2‐dp (rs, −0.57; P < 0.0001), and urinary excretion of isoprostanes (rs, −0.48; P < 0.0001) levels. The in vivo study showed a progressive decrease in platelet aggregation, sNox2‐dp, and urinary 8‐iso prostaglandin F2α‐III formation 2 hours and 3 days after albumin infusion. Finally, platelet aggregation, sNox2‐dp, and isoprostane formation significantly decreased in platelets from HSs incubated with scalar concentrations of albumin. Conclusion: Low serum albumin in LC is associated with PVT, suggesting that albumin could be a modulator of the hemostatic system through interference with mechanisms regulating platelet activation.

Published
2019

49. Erratum to: Portal vein thrombosis relevance on liver cirrhosis: Italian Venous Thrombotic Events Registry (Intern Emerg Med, 10.1007/s11739-016-1416-8)

Author

Violi F., Corazza G. R., Caldwell S. H., Perticone F., Gatta A., Angelico M., Farcomeni A., Masotti M., Napoleone L., Vestri A., Raparelli V., Basili S., PRO-LIVER Collaborators Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davı` Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodrıguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Raparelli Valeria, Talerico Giovanni, Proietti Marco, Romiti Giulio Francesco, Ruscio Eleonora, Toriello Filippo, Violi F., Corazza G.R., Caldwell S.H., Perticone F., Gatta A., Angelico M., Farcomeni A., Masotti M., Napoleone L., Vestri A., Raparelli V., Basili S., and PRO-LIVER Collaborators Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davı` Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodrıguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Raparelli Valeria, Talerico Giovanni, Proietti Marco, Romiti Giulio Francesco, Ruscio Eleonora, Toriello Filippo

Subjects
Splanchnic venous thrombosis Anticoagulants Liver failure Hepatocellular carcinoma Esophageal varices
Abstract

In the original publication, the second author name was incorrectly published as Roberto Gino Corazza. The correct name should read as “Gino Roberto Corazza”. Also, the PRO-LIVER Study Collaborator, Dr. Gabriella Carnevale Maffè has not been included in the Appendix by mistake. The name of Dr. Carnevale Maffe` should read in the Appendix as follows: Bergamaschi Gaetano, Carnevale Maffè Gabriella, Masotti Michela, Costanzo Filippo (I° Clinica Medica, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy).

Published
2016

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