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3. Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis

Author

Yang, Ju Dong, Abdelmalek, Manal F, Guy, Cynthia D, Gill, Ryan M, Lavine, Joel E, Yates, Katherine, Klair, Jagpal, Terrault, Norah A, Clark, Jeanne M, Unalp-Arida, Aynur, Diehl, Anna Mae, Suzuki, Ayako, Dasarathy, Srinivasan, Dasarathy, Jaividhya, Hawkins, Carol, McCullough, Arthur J, Pagadala, Mangesh, Pai, Rish, Sargent, Ruth, Bashir, Mustafa, Buie, Stephanie, Guy, Cynthia, Kigongo, Christopher, Pan, Yi-Ping, Piercy, Dawn, Chalasani, Naga, Cummings, Oscar W, Gawrieh, Samer, Ghabril, Marwan, Marri, Smitha, Ragozzino, Linda, Sandrasegaran, Kumar, Vuppalanchi, Raj, King, Debra, Osmack, Pat, Siegner, Joan, Stewart, Susan, Neuschwander-Tetri, Brent A, Torretta, Susan, Ang, Brandon, Behling, Cynthia, Bhatt, Archana, Loomba, Rohit, Middleton, Michael, Patton, Heather, Sirlin, Claude, Aouizerat, Bradley, Bass, Nathan M, Brandman, Danielle, Ferrell, Linda D, Gill, Ryan, Hameed, Bilal, Ramos, Claudia, Terrault, Norah, Ungermann, Ashley, Atla, Pradeep, Croft, Brandon, Garcia, Rebekah, Garcia, Sonia, Sheikh, Muhammad, Singh, Mandeep, Boyett, Sherry, Carucci, Laura, Contos, Melissa J, Kraft, Kenneth, Luketic, Velimir AC, Puri, Puneet, Sanyal, Arun J, Schlosser, Jolene, Siddiqui, Mohhamad S, Wolford, Ben, Ackermann, Sarah, Cooney, Shannon, Coy, David, Gelinas, Katie, Kowdley, Kris V, Lee, Maximillian, Pierce, Tracey, Mooney, Jody, Nelson, James E, Shaw, Cheryl, Siddique, Asma, Wang, Chia, Brunt, Elizabeth M, Fowler, Kathryn, Kleiner, David E, Grave, Gilman D, Doo, Edward C, Hoofnagle, Jay H, Robuck, Patricia R, Sherker, Averell, Belt, Patricia, Donithan, Michele, Hallinan, Erin, and Isaacson, Milana

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Liver Disease, Contraception/Reproduction, Prevention, Hepatitis, Estrogen, Chronic Liver Disease and Cirrhosis, Aging, Good Health and Well Being, Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Histocytochemistry, Hormones, Humans, Male, Menopause, Middle Aged, Non-alcoholic Fatty Liver Disease, Reproduction, Risk Factors, Sex Factors, United States, Young Adult, Gender Differences, Fibrosis, Risk Factor Analysis., Nonalcoholic Steatohepatitis Clinical Research Network, Risk Factor Analysis, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsSex and sex hormones can affect responses of patients with nonalcoholic fatty liver disease (NAFLD) to metabolic stress and development of hepatocyte injury and inflammation.MethodsWe collected data from 3 large U.S. studies of patients with NAFLD (between October 2004 and June 2013) to assess the association between histologic severity and sex, menopause status, synthetic hormone use, and menstrual abnormalities in 1112 patients with a histologic diagnosis of NAFLD. We performed logistic or ordinal logistic regression models, adjusting for covariates relevant to an increase of hepatic metabolic stress.ResultsPremenopausal women were at an increased risk of lobular inflammation, hepatocyte ballooning, and Mallory-Denk bodies than men and also at an increased risk of lobular inflammation and Mallory-Denk bodies than postmenopausal women (P < .01). Use of oral contraceptives was associated with an increased risk of lobular inflammation and Mallory-Denk bodies in premenopausal women, whereas hormone replacement therapy was associated with an increased risk of lobular inflammation in postmenopausal women (P < .05).ConclusionsBeing a premenopausal woman or a female user of synthetic hormones is associated with increased histologic severity of hepatocyte injury and inflammation among patients with NAFLD at given levels of hepatic metabolic stress.

Published
2017

6. Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

Author

Abrams, Stephanie H., Barlow, Sarah, Himes, Ryan, Krisnamurthy, Rajesh, Maldonado, Leanel, Mahabir, Rory, Carr, April, Bernstein, Kimberlee, Bramlage, Kristin, Cecil, Kim, DeVore, Stephanie, Kohli, Rohit, Lake, Kathleen, Podberesky, Daniel, Towbin, Alex, Xanthakos, Stavra, Allende, Daniela, Dasarathy, Srinivasan, McCullough, Arthur J., Pagadala, Mangesh, Pai, Rish, Winston, Cha'Ron, Behr, Gerald, Lavine, Joel E., Lefkowitch, Jay H., Mencin, Ali, Reynoso, Elena, Abdelmalek, Manal F., Bashir, Mustafa, Buie, Stephanie, Diehl, Anna Mae, Guy, Cynthia, Kigongo, Christopher, Malik, David, Pan, Yi-Ping, Piercy, Dawn, Kopping, Mariko, Thrasher, Tyler, Alazraki, Adina, Cleeton, Rebecca, Cordero, Maria, Hernandez, Albert, Karpen, Saul, Munos, Jessica Cruz, Raviele, Nicholas, Vos, Miriam, Bozic, Molly, Chalasani, Naga, Cummings, Oscar W., Gawrieh, Samer, Klipsch, Ann, Molleston, Jean P., Ragozzino, Emily, Ragozzino, Linda, Sandrasegaran, Kumar, Subbarao, Girish, Vuppalanchi, Raj, Walker, Laura, Kafka, Kimberly, Scheimann, Ann, Ito, Joy, Fishbein, Mark H., Mohammad, Saeed, Rigsby, Cynthia, Sharda, Lisa, Whitington, Peter F., Cattoor, Theresa, Derdoy, Jose, Freebersyser, Janet, Jain, Ajay, King, Debra, Lai, Jinping, Osmack, Pat, Siegner, Joan, Stewart, Susan, Neuschwander-Tetri, Brent A., Torretta, Susan, Wriston, Kristina, Assadian, Fereshteh, Barone, Vanessa, Gonzalez, Maria Cardona, Davila, Jodie, Fix, Oren, Hennessey, Kelly Anne, Kowdley, Kris V., Lopez, Kacie, Ness, Erik, Poitevin, Michelle, Procaccini, Nicholas, Quist, Brook, Saddic, Alana, Wiseman, Cara, Yeh, Matthew, Baker, Susan S., Lopez-Graham, Diana, Williams, Sonja, Zhu, Lixin, Africa, Jonathan, Ang, Brandon, Awai, Hannah, Behling, Cynthia, Bhatt, Archana, Bross, Craig, Collins, Jennifer, Durelle, Janis, Harlow, Kathryn, Loomba, Rohit, Middleton, Michael, Newton, Kimberly, Paiz, Melissa, Schwimmer, Jeffrey B., Sirlin, Claude, Ugalde-Nicalo, Patricia, Villarreal, Mariana Dominguez, Aouizerat, Bradley, Bass, Nathan M., Brandman, Danielle, Courtier, Jesse, Ferrell, Linda D., Feier, Natasha, Gill, Ryan, Hameed, Bilal, Langlois, Camille, Maher, Jacqueline, Perito, Emily Rothbaum, Ramos, Claudia, Rosenthal, Philip, Terrault, Norah, Tsai, Patrika, Ungermann, Ashley, Atla, Pradeep, Croft, Brandon, Garcia, Rebekah, Garcia, Sonia, Sheikh, Muhammad, Singh, Mandeep, Cooper, Kara, Horslen, Simon, Hsu, Evelyn, Murray, Karen, Otto, Randolph, Young, Melissa, Boyett, Sherry, Carucci, Laura, Contos, Melissa J., Kirwin, Sherri, Kraft, Kenneth, Luketic, Velimir A.C., Puri, Puneet, Sanyal, Arun J., Schlosser, Jolene, Siddiqui, Mohammad S., Brunt, Elizabeth M., Fowler, Kathryn, Kleiner, David E., Brown, Sherry, Doo, Edward C., Hoofnagle, Jay H., Robuck, Patricia R., Sherker, Averell, Torrance, Rebecca, Belt, Patricia, Clark, Jeanne M., Donithan, Michele, Hallinan, Erin, Isaacson, Milana, May, Kevin P., Miriel, Laura, Sternberg, Alice, Tonascia, James, Van Natta, Mark, Wilson, Laura, Yates, Katherine, Newton, Kimberly P., Feldman, Haruna S., and Chambers, Christina D.

Published
2017
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7. Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis

Author

Dasarathy, Srinivasan, Dasarathy, Jaividhya, Hawkins, Carol, McCullough, Arthur J., Pagadala, Mangesh, Pai, Rish, Sargent, Ruth, Abdelmalek, Manal F., Bashir, Mustafa, Buie, Stephanie, Diehl, Anna Mae, Guy, Cynthia, Kigongo, Christopher, Pan, Yi-Ping, Piercy, Dawn, Chalasani, Naga, Cummings, Oscar W., Gawrieh, Samer, Ghabril, Marwan, Marri, Smitha, Ragozzino, Linda, Sandrasegaran, Kumar, Vuppalanchi, Raj, King, Debra, Osmack, Pat, Siegner, Joan, Stewart, Susan, Neuschwander-Tetri, Brent A., Torretta, Susan, Ang, Brandon, Behling, Cynthia, Bhatt, Archana, Loomba, Rohit, Middleton, Michael, Patton, Heather, Sirlin, Claude, Aouizerat, Bradley, Bass, Nathan M., Brandman, Danielle, Ferrell, Linda D., Gill, Ryan, Hameed, Bilal, Ramos, Claudia, Terrault, Norah, Ungermann, Ashley, Atla, Pradeep, Croft, Brandon, Garcia, Rebekah, Garcia, Sonia, Sheikh, Muhammad, Singh, Mandeep, Boyett, Sherry, Carucci, Laura, Contos, Melissa J., Kraft, Kenneth, Luketic, Velimir A.C., Puri, Puneet, Sanyal, Arun J., Schlosser, Jolene, Siddiqui, Mohhamad S., Wolford, Ben, Ackermann, Sarah, Cooney, Shannon, Coy, David, Gelinas, Katie, Kowdley, Kris V., Lee, Maximillian, Pierce, Tracey, Mooney, Jody, Nelson, James E., Shaw, Cheryl, Siddique, Asma, Wang, Chia, Brunt, Elizabeth M., Fowler, Kathryn, Kleiner, David E., Grave, Gilman D., Doo, Edward C., Hoofnagle, Jay H., Robuck, Patricia R., Sherker, Averell, Belt, Patricia, Clark, Jeanne M., Donithan, Michele, Hallinan, Erin, Isaacson, Milana, May, Kevin P., Miriel, Laura, Sternberg, Alice, Tonascia, James, Ünalp-Arida, Aynur, Van Natta, Mark, Vaughn, Ivana, Wilson, Laura, Yates, Katherine, Yang, Ju Dong, Guy, Cynthia D., Gill, Ryan M., Lavine, Joel E., Klair, Jagpal, Terrault, Norah A., Unalp-Arida, Aynur, and Suzuki, Ayako

Published
2017
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9. Abstract OT1-03-06: Phase 1b/2 study of ladiratuzumab vedotin (LV) in combination with pembrolizumab for first-line treatment of triple-negative breast cancer (SGNLVA-002, trial in progress)

Author

Dillon, Patrick, primary, Basho, Reva, additional, Han, Hyo S., additional, Kolberg, Hans-Christian, additional, Tkaczuk, Katherine, additional, Zahrah, George, additional, Gion, Maria, additional, Voss, Herman, additional, Meisel, Jane, additional, Pluard, Timothy, additional, Fox, Jenny, additional, Oliveira, Mafalda, additional, Brown-Glaberman, Ursa, additional, Stringer-Reasor, Erica, additional, Manso, Luis, additional, Küemmel, Sherko, additional, Chen, Lin Chi, additional, Wu, Sheng, additional, Croft, Brandon, additional, and Boni, Valentina, additional

Published
2023
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11. Navtemadlin (KRT-232) in combination with avelumab for patients with anti-PD-1/L1 treatment-naïve TP53 Merkel cell carcinoma (MCC)

Author

Wong, Michael K., primary, Burgess, Melissa, additional, Chandra, Sunandana, additional, Schadendorf, Dirk, additional, Silk, Ann, additional, Olszanski, Anthony J., additional, Grob, Jean-Jacques, additional, Jang, Sekwon, additional, Grewal, Jaspreet Singh, additional, Lewis, Karl D., additional, Fecher, Leslie, additional, Rabinowits, Guilherme, additional, Lebbe, Celeste, additional, Martin-Liberal, Juan, additional, Di Giacomo, Anna Maria, additional, Friedlander, Philip, additional, Brohl, Andrew S., additional, Croft, Brandon, additional, McGreivy, Jesse S., additional, Rothbaum, Wayne P., additional, Hanna, Glenn J., additional, and Kelly, Ciara M., additional

Published
2022
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13. An open-label, multicenter, phase 2 study of the safety and efficacy of navtemadlin (KRT-232) in patients with TP53 wild-type relapsed/refractory small cell lung cancer.

Author

Dowlati, Afshin, primary, Juan-Vidal, Oscar, additional, Hiret, Sandrine, additional, Rittmeyer, Achim, additional, Sukumaran, Shawgi, additional, Vicente Baz, David, additional, Rios-Perez, Jorge Arturo, additional, Harris, Eric Michael, additional, McCune, Steven L., additional, Johnson, Melissa Lynne, additional, Croft, Brandon, additional, McGreivy, Jesse S., additional, Rothbaum, Wayne P., additional, and de Castro Carpeño, Javier, additional

Published
2022
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15. Polatuzumab vedotin + obinutuzumab + venetoclax in patients with relapsed/refractory (R/R) follicular lymphoma (FL): Primary analysis of a phase 1b/2 trial.

Author

Bannerji, Rajat, primary, Yuen, Sam, additional, Phillips, Tycel Jovelle, additional, Arthur, Christopher, additional, Isufi, Iris, additional, Marlton, Paula, additional, Seymour, John Francis, additional, Corradini, Paolo, additional, Molinari, Annalia, additional, Gritti, Giuseppe, additional, Emmons, Robert, additional, Hirata, Jamie, additional, Musick, Lisa, additional, Saha, Sourish, additional, Croft, Brandon, additional, and Flowers, Christopher, additional

Published
2021
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16. Polatuzumab vedotin (Pola) + rituximab (R) + lenalidomide (Len) in patients (pts) with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL): Primary analysis of a phase 1b/2 trial.

Author

Magid Diefenbach, Catherine S., primary, Abrisqueta, Pau, additional, Gonzalez-Barca, Eva, additional, Panizo, Carlos, additional, Arguinano Perez, Jose Maria, additional, Miall, Fiona, additional, Bastos-Oreiro, Mariana, additional, Lopez-Guillermo, Armando, additional, Banerjee, Lalita, additional, McMillan, Andrew, additional, Hirata, Jamie, additional, Musick, Lisa, additional, Saha, Sourish, additional, Croft, Brandon, additional, and Seymour, Erlene Kuizon, additional

Published
2021
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19. Polatuzumab Vedotin Plus Bendamustine with Rituximab in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Updated Results of a Phase Ib/II Randomized Study

Author

Sehn, Laurie H, primary, Matasar, Matthew J, additional, Flowers, Christopher R., additional, Kamdar, Manali, additional, McMillan, Andrew K, additional, Hertzberg, Mark, additional, Assouline, Sarit, additional, Kim, Tae Min, additional, Kim, Won Seog, additional, Ozcan, Muhit, additional, Croft, Brandon, additional, Hirata, Jamie, additional, Cheng, Ji, additional, Ku, Grace, additional, and Herrera, Alex F., additional

Published
2019
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21. Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

Author

Newton, Kimberly P., primary, Feldman, Haruna S., additional, Chambers, Christina D., additional, Wilson, Laura, additional, Behling, Cynthia, additional, Clark, Jeanne M., additional, Molleston, Jean P., additional, Chalasani, Naga, additional, Sanyal, Arun J., additional, Fishbein, Mark H., additional, Lavine, Joel E., additional, Schwimmer, Jeffrey B., additional, Abrams, Stephanie H., additional, Barlow, Sarah, additional, Himes, Ryan, additional, Krisnamurthy, Rajesh, additional, Maldonado, Leanel, additional, Mahabir, Rory, additional, Carr, April, additional, Bernstein, Kimberlee, additional, Bramlage, Kristin, additional, Cecil, Kim, additional, DeVore, Stephanie, additional, Kohli, Rohit, additional, Lake, Kathleen, additional, Podberesky, Daniel, additional, Towbin, Alex, additional, Xanthakos, Stavra, additional, Allende, Daniela, additional, Dasarathy, Srinivasan, additional, McCullough, Arthur J., additional, Pagadala, Mangesh, additional, Pai, Rish, additional, Winston, Cha'Ron, additional, Behr, Gerald, additional, Lefkowitch, Jay H., additional, Mencin, Ali, additional, Reynoso, Elena, additional, Abdelmalek, Manal F., additional, Bashir, Mustafa, additional, Buie, Stephanie, additional, Diehl, Anna Mae, additional, Guy, Cynthia, additional, Kigongo, Christopher, additional, Malik, David, additional, Pan, Yi-Ping, additional, Piercy, Dawn, additional, Kopping, Mariko, additional, Thrasher, Tyler, additional, Alazraki, Adina, additional, Cleeton, Rebecca, additional, Cordero, Maria, additional, Hernandez, Albert, additional, Karpen, Saul, additional, Munos, Jessica Cruz, additional, Raviele, Nicholas, additional, Vos, Miriam, additional, Bozic, Molly, additional, Cummings, Oscar W., additional, Gawrieh, Samer, additional, Klipsch, Ann, additional, Ragozzino, Emily, additional, Ragozzino, Linda, additional, Sandrasegaran, Kumar, additional, Subbarao, Girish, additional, Vuppalanchi, Raj, additional, Walker, Laura, additional, Kafka, Kimberly, additional, Scheimann, Ann, additional, Ito, Joy, additional, Mohammad, Saeed, additional, Rigsby, Cynthia, additional, Sharda, Lisa, additional, Whitington, Peter F., additional, Cattoor, Theresa, additional, Derdoy, Jose, additional, Freebersyser, Janet, additional, Jain, Ajay, additional, King, Debra, additional, Lai, Jinping, additional, Osmack, Pat, additional, Siegner, Joan, additional, Stewart, Susan, additional, Neuschwander-Tetri, Brent A., additional, Torretta, Susan, additional, Wriston, Kristina, additional, Assadian, Fereshteh, additional, Barone, Vanessa, additional, Gonzalez, Maria Cardona, additional, Davila, Jodie, additional, Fix, Oren, additional, Hennessey, Kelly Anne, additional, Kowdley, Kris V., additional, Lopez, Kacie, additional, Ness, Erik, additional, Poitevin, Michelle, additional, Procaccini, Nicholas, additional, Quist, Brook, additional, Saddic, Alana, additional, Wiseman, Cara, additional, Yeh, Matthew, additional, Baker, Susan S., additional, Lopez-Graham, Diana, additional, Williams, Sonja, additional, Zhu, Lixin, additional, Africa, Jonathan, additional, Ang, Brandon, additional, Awai, Hannah, additional, Bhatt, Archana, additional, Bross, Craig, additional, Collins, Jennifer, additional, Durelle, Janis, additional, Harlow, Kathryn, additional, Loomba, Rohit, additional, Middleton, Michael, additional, Newton, Kimberly, additional, Paiz, Melissa, additional, Sirlin, Claude, additional, Ugalde-Nicalo, Patricia, additional, Villarreal, Mariana Dominguez, additional, Aouizerat, Bradley, additional, Bass, Nathan M., additional, Brandman, Danielle, additional, Courtier, Jesse, additional, Ferrell, Linda D., additional, Feier, Natasha, additional, Gill, Ryan, additional, Hameed, Bilal, additional, Langlois, Camille, additional, Maher, Jacqueline, additional, Perito, Emily Rothbaum, additional, Ramos, Claudia, additional, Rosenthal, Philip, additional, Terrault, Norah, additional, Tsai, Patrika, additional, Ungermann, Ashley, additional, Atla, Pradeep, additional, Croft, Brandon, additional, Garcia, Rebekah, additional, Garcia, Sonia, additional, Sheikh, Muhammad, additional, Singh, Mandeep, additional, Cooper, Kara, additional, Horslen, Simon, additional, Hsu, Evelyn, additional, Murray, Karen, additional, Otto, Randolph, additional, Young, Melissa, additional, Boyett, Sherry, additional, Carucci, Laura, additional, Contos, Melissa J., additional, Kirwin, Sherri, additional, Kraft, Kenneth, additional, Luketic, Velimir A.C., additional, Puri, Puneet, additional, Schlosser, Jolene, additional, Siddiqui, Mohammad S., additional, Brunt, Elizabeth M., additional, Fowler, Kathryn, additional, Kleiner, David E., additional, Brown, Sherry, additional, Doo, Edward C., additional, Hoofnagle, Jay H., additional, Robuck, Patricia R., additional, Sherker, Averell, additional, Torrance, Rebecca, additional, Belt, Patricia, additional, Donithan, Michele, additional, Hallinan, Erin, additional, Isaacson, Milana, additional, May, Kevin P., additional, Miriel, Laura, additional, Sternberg, Alice, additional, Tonascia, James, additional, Van Natta, Mark, additional, and Yates, Katherine, additional

Published
2017
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22. Navtemadlin (KRT-232) in combination with avelumab for patients with anti-PD-1/L1 treatment-naïve TP53WTMerkel cell carcinoma (MCC)

Author

Wong, Michael K., Burgess, Melissa, Chandra, Sunandana, Schadendorf, Dirk, Silk, Ann, Olszanski, Anthony J., Grob, Jean-Jacques, Jang, Sekwon, Grewal, Jaspreet Singh, Lewis, Karl D., Fecher, Leslie, Rabinowits, Guilherme, Lebbe, Celeste, Martin-Liberal, Juan, Di Giacomo, Anna Maria, Friedlander, Philip, Brohl, Andrew S., Croft, Brandon, McGreivy, Jesse S., Rothbaum, Wayne P., Hanna, Glenn J., and Kelly, Ciara M.

Published
2022
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23. Ubiquitin-Proteasome System in Neurodegenerative Disorders.

Author

Rao G, Croft B, Teng C, and Awasthi V

Abstract

Cellular proteostasis is a highly dynamic process and is primarily carried out by the degradation tools of ubiquitin-proteasome system (UPS). Abnormalities in UPS function result in the accumulation of damaged or misfolded proteins which can form intra- and extracellular aggregated proteinaceous deposits leading to cellular dysfunction and/or death. Deposition of abnormal protein aggregates and the cellular inability to clear them have been implicated in the pathogenesis of a number of neurodegenerative disorders such as Alzheimer's and Parkinson's. Contrary to the upregulation of proteasome function in oncogenesis and the use of proteasome inhibition as a therapeutic strategy, activation of proteasome function would serve therapeutic objectives of treatment of neurodegenerative diseases. This review describes the current understanding of the role of the proteasome in neurodegenerative disorders and potential utility of proteasomal modulation therein.

Published
2015
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