Search

Your search keyword '"Crosbie, E"' showing total 432 results
Start Over Author "Crosbie, E"
432 results on '"Crosbie, E"'

2. p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial

Author

Vermij, Lisa, Léon-Castillo, Alicia, Singh, Naveena, Powell, Melanie E., Edmondson, Richard J., Genestie, Catherine, Khaw, Pearly, Pyman, Jan, McLachlin, C. Meg, Ghatage, Prafull, de Boer, Stephanie M., Nijman, Hans W., Smit, Vincent T.H.B.M., Crosbie, Emma J., Leary, Alexandra, Creutzberg, Carien L., Horeweg, Nanda, Bosse, Tjalling, Horeweg, N., de Boer, S.M., Creutzberg, C.L., Bosse, T., Smit, V.T.H.B.M., Kroep, J., Nout, R.A., Nijman, H.W., de Bruyn, M., Powell, M.E., Singh, N., Kitchener, H.C., Crosbie, E., Edmondson, R., Church, D.N., Leary, A., Mileshkin, L., Pollock, P.M., and MacKay, H.

Published
2022
Full Text
View/download PDF

3. Clinical research in endometrial cancer: consensus recommendations from the Gynecologic Cancer InterGroup

Author

Creutzberg, C, Kim, J, Eminowicz, G, Allanson, E, Eberst, L, Kim, S, Nout, R, Park, J, Lorusso, D, Mileshkin, L, Ottevanger, P, Brand, A, Mezzanzanica, D, Oza, A, Gebski, V, Pothuri, B, Batley, T, Gordon, C, Mitra, T, White, H, Howitt, B, Matias-Guiu, X, Ray-Coquard, I, Gaffney, D, Small, W, Miller, A, Concin, N, Powell, M, Stuart, G, Bookman, M, Barretina-Ginesta, P, Bennett, K, Berek, J, Berger, R, Bjorge, L, Boere, I, Brennan, D, Bruchim, I, Chang, T, Chavez Blanco, A, Chen, X, Colombo, N, Crosbie, E, Denys, H, Duska, L, Fruehauf, F, Gomez Garcia, E, van Gorp, T, Grimm, C, Guitmann, G, Han, K, Hanker, L, Harano, K, Hasegawa, K, Herrington, C, Ip, P, Joly, F, Khaw, P, Kohn, E, Kristeleit, R, Kroep, J, Leary, A, Lee, J, Lheureux, S, Liu, J, Mackay, H, Mahner, S, Mariani, A, Mcalpine, J, Mikami, Y, Mirza, M, Mukhopadhyay, A, Nagao, S, Ng, J, Nogueira-Rodrigues, A, Novak, Z, O'Donnell, J, Osborne, S, Perez-Fidalgo, J, Romeo Marin, M, Roy Chowdhury, R, Sadozye, A, Safra, T, Scott, C, Sehouli, J, Slomovitz, B, Tan, D, Taylor, A, Valabrega, G, Veneziani, A, Verhoeven, K, Vetter, M, Wampfler, J, Westin, S, Wimberger, P, Zola, P, Creutzberg C. L., Kim J. -W., Eminowicz G., Allanson E., Eberst L., Kim S. I., Nout R. A., Park J. -Y., Lorusso D., Mileshkin L., Ottevanger P. B., Brand A., Mezzanzanica D., Oza A., Gebski V., Pothuri B., Batley T., Gordon C., Mitra T., White H., Howitt B., Matias-Guiu X., Ray-Coquard I., Gaffney D., Small W., Miller A., Concin N., Powell M. A., Stuart G., Bookman M. A., Barretina-Ginesta P., Bennett K., Berek J., Berger R., Bjorge L., Boere I., Brennan D., Bruchim I., Chang T. -C., Chavez Blanco A., Chen X., Colombo N., Crosbie E., Denys H., Duska L., Fruehauf F., Gomez Garcia E. M., van Gorp T., Grimm C., Guitmann G., Han K., Hanker L., Harano K., Hasegawa K., Herrington C. S., Ip P., Joly F., Khaw P., Kohn E., Kristeleit R., Kroep J., Leary A., Lee J. -Y., Lheureux S., Liu J., Mackay H., Mahner S., Mariani A., McAlpine J., Mikami Y., Mirza M. R., Mukhopadhyay A., Nagao S., Ng J., Nogueira-Rodrigues A., Novak Z., O'Donnell J., Osborne S., Perez-Fidalgo J. A., Romeo Marin M., Roy Chowdhury R., Sadozye A., Safra T., Scott C., Sehouli J., Slomovitz B., Tan D., Taylor A., Valabrega G., Veneziani A., Verhoeven K., Vetter M., Wampfler J., Westin S., Wimberger P., Zola P., Creutzberg, C, Kim, J, Eminowicz, G, Allanson, E, Eberst, L, Kim, S, Nout, R, Park, J, Lorusso, D, Mileshkin, L, Ottevanger, P, Brand, A, Mezzanzanica, D, Oza, A, Gebski, V, Pothuri, B, Batley, T, Gordon, C, Mitra, T, White, H, Howitt, B, Matias-Guiu, X, Ray-Coquard, I, Gaffney, D, Small, W, Miller, A, Concin, N, Powell, M, Stuart, G, Bookman, M, Barretina-Ginesta, P, Bennett, K, Berek, J, Berger, R, Bjorge, L, Boere, I, Brennan, D, Bruchim, I, Chang, T, Chavez Blanco, A, Chen, X, Colombo, N, Crosbie, E, Denys, H, Duska, L, Fruehauf, F, Gomez Garcia, E, van Gorp, T, Grimm, C, Guitmann, G, Han, K, Hanker, L, Harano, K, Hasegawa, K, Herrington, C, Ip, P, Joly, F, Khaw, P, Kohn, E, Kristeleit, R, Kroep, J, Leary, A, Lee, J, Lheureux, S, Liu, J, Mackay, H, Mahner, S, Mariani, A, Mcalpine, J, Mikami, Y, Mirza, M, Mukhopadhyay, A, Nagao, S, Ng, J, Nogueira-Rodrigues, A, Novak, Z, O'Donnell, J, Osborne, S, Perez-Fidalgo, J, Romeo Marin, M, Roy Chowdhury, R, Sadozye, A, Safra, T, Scott, C, Sehouli, J, Slomovitz, B, Tan, D, Taylor, A, Valabrega, G, Veneziani, A, Verhoeven, K, Vetter, M, Wampfler, J, Westin, S, Wimberger, P, Zola, P, Creutzberg C. L., Kim J. -W., Eminowicz G., Allanson E., Eberst L., Kim S. I., Nout R. A., Park J. -Y., Lorusso D., Mileshkin L., Ottevanger P. B., Brand A., Mezzanzanica D., Oza A., Gebski V., Pothuri B., Batley T., Gordon C., Mitra T., White H., Howitt B., Matias-Guiu X., Ray-Coquard I., Gaffney D., Small W., Miller A., Concin N., Powell M. A., Stuart G., Bookman M. A., Barretina-Ginesta P., Bennett K., Berek J., Berger R., Bjorge L., Boere I., Brennan D., Bruchim I., Chang T. -C., Chavez Blanco A., Chen X., Colombo N., Crosbie E., Denys H., Duska L., Fruehauf F., Gomez Garcia E. M., van Gorp T., Grimm C., Guitmann G., Han K., Hanker L., Harano K., Hasegawa K., Herrington C. S., Ip P., Joly F., Khaw P., Kohn E., Kristeleit R., Kroep J., Leary A., Lee J. -Y., Lheureux S., Liu J., Mackay H., Mahner S., Mariani A., McAlpine J., Mikami Y., Mirza M. R., Mukhopadhyay A., Nagao S., Ng J., Nogueira-Rodrigues A., Novak Z., O'Donnell J., Osborne S., Perez-Fidalgo J. A., Romeo Marin M., Roy Chowdhury R., Sadozye A., Safra T., Scott C., Sehouli J., Slomovitz B., Tan D., Taylor A., Valabrega G., Veneziani A., Verhoeven K., Vetter M., Wampfler J., Westin S., Wimberger P., and Zola P.

Abstract

The Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Consensus Conference on Clinical Research (ECCC) was held in Incheon, South Korea, Nov 2–3, 2023. The aims were to develop consensus statements for future trials in endometrial cancer to achieve harmonisation on design elements, select important questions, and identify unmet needs. All 33 GCIG member groups participated in the development, refinement, and finalisation of 18 statements within four topic groups, addressing adjuvant treatment in high-risk disease; treatment for metastatic and recurrent disease; trial designs for rare endometrial cancer subgroups and special circumstances; and specific methodology and adaptation for trials in low-resource settings. In addition, eight areas of unmet need were identified. This was the first GCIG Consensus Conference to include patient advocates and an expert on inclusion, diversity, equity, and access to take part in all aspects of the process and output. Four early-career investigators were also selected for participation, ensuring that they represented different GCIG member groups and regions. Unanimous consensus was obtained for 16 of the 18 statements, with 97% concordance for the remaining two. Using the described methodology from previous Ovarian Cancer Consensus Conferences, this conference did not require even one minority statement. The high acceptance rate following active involvement in the preparation, discussion, and refinement of the statements by all representatives confirmed the consensus progress within a global academic setting, and the expectation that the ECCC will lead to greater harmonisation, actualisation, inclusion, and resolution of unmet needs in clinical research for individuals living with and beyond endometrial cancer worldwide.

Published
2024

4. Contrasting aerosol refractive index and hygroscopicity in the inflow and outflow of deep convective storms: Analysis of airborne data from DC3

Author

Sorooshian, Armin, Shingler, T, Crosbie, E, Barth, MC, Homeyer, CR, Campuzano‐Jost, P, Day, DA, Jimenez, JL, Thornhill, KL, Ziemba, LD, Blake, DR, and Fried, A

Subjects
Climate Action, DC3, aerosol, hygroscopicity, refractive index, entrainment, cloud processing, Atmospheric Sciences, Physical Geography and Environmental Geoscience
Abstract

We examine three case studies during the Deep Convective Clouds and Chemistry (DC3) field experiment when storm inflow and outflow air were sampled for aerosol subsaturated hygroscopicity and the real part of refractive index (n) with a Differential Aerosol Sizing and Hygroscopicity Probe (DASH-SP) on the NASA DC-8. Relative to inflow aerosol particles, outflow particles were more hygroscopic (by 0.03 based on the estimated κ parameter) in one of the three storms examined. Two of three “control” flights with no storm convection reveal higher κ values, albeit by only 0.02, at high altitude (> 8 km) versus < 4 km. Entrainment modeling shows that measured κ values in the outflow of the three storm flights are higher than predicted values (by 0.03-0.11) based on knowledge of κ values from the inflow and clear air adjacent to the storms. This suggests that other process(es) contributed to hygroscopicity enhancements such as secondary aerosol formation via aqueous-phase chemistry. Values of n were higher in the outflow of two of the three storm flights, reaching as high as 1.54. More statistically significant differences were observed in control flights (no storms) where n decreased from 1.50-1.52 (< 4 km) to 1.49-1.50 (> 8 km). Chemical data show that enhanced hygroscopicity was coincident with lower organic mass fractions, higher sulfate mass fractions, and higher O: C ratios of organic aerosol. Refractive index did not correlate as well with available chemical data. Deep convection is shown to alter aerosol radiative properties, which has implications for aerosol effects on climate.

Published
2017

5. Observational evidence for the convective transport of dust over the Central United States

Author

Corr, CA, Ziemba, LD, Scheuer, E, Anderson, BE, Beyersdorf, AJ, Chen, G, Crosbie, E, Moore, RH, Shook, M, Thornhill, KL, Winstead, E, Lawson, RP, Barth, MC, Schroeder, JR, Blake, DR, and Dibb, JE

Subjects
Climate Action, mineral dust, convection, vertical transport, ice nuclei, Atmospheric Sciences, Physical Geography and Environmental Geoscience
Abstract

Bulk aerosol composition and aerosol size distributions measured aboard the DC-8 aircraft during the Deep Convective Clouds and Chemistry Experiment mission in May/June 2012 were used to investigate the transport of mineral dust through nine storms encountered over Colorado and Oklahoma. Measurements made at low altitudes ( 9 km MSL). Storm mean outflow Ca2+ mass concentrations and total coarse (1 μm < diameter < 5 μm) aerosol volume (Vc) were comparable to mean inflow values as demonstrated by average outflow/inflow ratios greater than 0.5. A positive relationship between Ca2+, Vc, ice water content, and large (diameter > 50 μm) ice particle number concentrations was not evident; thus, the influence of ice shatter on these measurements was assumed small. Mean inflow aerosol number concentrations calculated over a diameter range (0.5 μm < diameter < 5.0 μm) relevant for proxy ice nuclei (NPIN) were ~15–300 times higher than ice particle concentrations for all storms. Ratios of predicted interstitial NPIN (calculated as the difference between inflow NPIN and ice particle concentrations) and inflow NPIN were consistent with those calculated for Ca2+ and Vc and indicated that on average less than 10% of the ingested NPIN were activated as ice nuclei during anvil formation. Deep convection may therefore represent an efficient transport mechanism for dust to the upper troposphere where these particles can function as ice nuclei cirrus forming in situ.

Published
2016

6. Dominantly inherited micro-satellite instable cancer – the four Lynch syndromes - an EHTG, PLSD position statement

Author

Moller, P, Seppala, T, Ahadova, A, Crosbie, E, Holinski-Feder, E, Scott, R, Haupt, S, Moslein, G, Winship, I, Broeke, S, Kohut, K, Ryan, N, Bauerfeind, P, Thomas, L, Evans, D, Aretz, S, Sijmons, R, Half, E, Heinimann, K, Horisberger, K, Monahan, K, Engel, C, Cavestro, G, Fruscio, R, Abu-Freha, N, Zohar, L, Laghi, L, Bertario, L, Bonanni, B, Tibiletti, M, Lino-Silva, L, Vaccaro, C, Valle, A, Rossi, B, da Silva, L, de Oliveira Nascimento, I, Rossi, N, Debniak, T, Mecklin, J, Bernstein, I, Lindblom, A, Sunde, L, Nakken, S, Heuveline, V, Burn, J, Hovig, E, Kloor, M, Sampson, J, Dominguez-Valentin, M, Moller P., Seppala T. T., Ahadova A., Crosbie E. J., Holinski-Feder E., Scott R., Haupt S., Moslein G., Winship I., Broeke S. W. B. -T., Kohut K. E., Ryan N., Bauerfeind P., Thomas L. E., Evans D. G., Aretz S., Sijmons R. H., Half E., Heinimann K., Horisberger K., Monahan K., Engel C., Cavestro G. M., Fruscio R., Abu-Freha N., Zohar L., Laghi L., Bertario L., Bonanni B., Tibiletti M. G., Lino-Silva L. S., Vaccaro C., Valle A. D., Rossi B. M., da Silva L. A., de Oliveira Nascimento I. L., Rossi N. T., Debniak T., Mecklin J. -P., Bernstein I., Lindblom A., Sunde L., Nakken S., Heuveline V., Burn J., Hovig E., Kloor M., Sampson J. R., Dominguez-Valentin M., Moller, P, Seppala, T, Ahadova, A, Crosbie, E, Holinski-Feder, E, Scott, R, Haupt, S, Moslein, G, Winship, I, Broeke, S, Kohut, K, Ryan, N, Bauerfeind, P, Thomas, L, Evans, D, Aretz, S, Sijmons, R, Half, E, Heinimann, K, Horisberger, K, Monahan, K, Engel, C, Cavestro, G, Fruscio, R, Abu-Freha, N, Zohar, L, Laghi, L, Bertario, L, Bonanni, B, Tibiletti, M, Lino-Silva, L, Vaccaro, C, Valle, A, Rossi, B, da Silva, L, de Oliveira Nascimento, I, Rossi, N, Debniak, T, Mecklin, J, Bernstein, I, Lindblom, A, Sunde, L, Nakken, S, Heuveline, V, Burn, J, Hovig, E, Kloor, M, Sampson, J, Dominguez-Valentin, M, Moller P., Seppala T. T., Ahadova A., Crosbie E. J., Holinski-Feder E., Scott R., Haupt S., Moslein G., Winship I., Broeke S. W. B. -T., Kohut K. E., Ryan N., Bauerfeind P., Thomas L. E., Evans D. G., Aretz S., Sijmons R. H., Half E., Heinimann K., Horisberger K., Monahan K., Engel C., Cavestro G. M., Fruscio R., Abu-Freha N., Zohar L., Laghi L., Bertario L., Bonanni B., Tibiletti M. G., Lino-Silva L. S., Vaccaro C., Valle A. D., Rossi B. M., da Silva L. A., de Oliveira Nascimento I. L., Rossi N. T., Debniak T., Mecklin J. -P., Bernstein I., Lindblom A., Sunde L., Nakken S., Heuveline V., Burn J., Hovig E., Kloor M., Sampson J. R., and Dominguez-Valentin M.

Abstract

The recognition of dominantly inherited micro-satellite instable (MSI) cancers caused by pathogenic variants in one of the four mismatch repair (MMR) genes MSH2, MLH1, MSH6 and PMS2 has modified our understanding of carcinogenesis. Inherited loss of function variants in each of these MMR genes cause four dominantly inherited cancer syndromes with different penetrance and expressivities: the four Lynch syndromes. No person has an “average sex “or a pathogenic variant in an “average Lynch syndrome gene” and results that are not stratified by gene and sex will be valid for no one. Carcinogenesis may be a linear process from increased cellular division to localized cancer to metastasis. In addition, in the Lynch syndromes (LS) we now recognize a dynamic balance between two stochastic processes: MSI producing abnormal cells, and the host’s adaptive immune system’s ability to remove them. The latter may explain why colonoscopy surveillance does not reduce the incidence of colorectal cancer in LS, while it may improve the prognosis. Most early onset colon, endometrial and ovarian cancers in LS are now cured and most cancer related deaths are after subsequent cancers in other organs. Aspirin reduces the incidence of colorectal and other cancers in LS. Immunotherapy increases the host immune system’s capability to destroy MSI cancers. Colonoscopy surveillance, aspirin prevention and immunotherapy represent major steps forward in personalized precision medicine to prevent and cure inherited MSI cancer.

Published
2023

7. Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database

Author

Dominguez-Valentin, M, Haupt, S, Seppälä, T, Sampson, J, Sunde, L, Bernstein, I, Jenkins, M, Engel, C, Aretz, S, Nielsen, M, Capella, G, Balaguer, F, Evans, D, Burn, J, Holinski-Feder, E, Bertario, L, Bonanni, B, Lindblom, A, Levi, Z, Macrae, F, Winship, I, Plazzer, J, Sijmons, R, Laghi, L, Della Valle, A, Heinimann, K, Dębniak, T, Fruscio, R, Lopez-Koestner, F, Alvarez-Valenzuela, K, Katz, L, Laish, I, Vainer, E, Vaccaro, C, Carraro, D, Monahan, K, Half, E, Stakelum, A, Winter, D, Kennelly, R, Gluck, N, Sheth, H, Abu-Freha, N, Greenblatt, M, Rossi, B, Bohorquez, M, Cavestro, G, Lino-Silva, L, Horisberger, K, Tibiletti, M, Nascimento, I, Thomas, H, Rossi, N, Apolinário da Silva, L, Zaránd, A, Ruiz-Bañobre, J, Heuveline, V, Mecklin, J, Pylvänäinen, K, Renkonen-Sinisalo, L, Lepistö, A, Peltomäki, P, Therkildsen, C, Madsen, M, Burgdorf, S, Hopper, J, Win, A, Haile, R, Lindor, N, Gallinger, S, Le Marchand, L, Newcomb, P, Figueiredo, J, Buchanan, D, Thibodeau, S, von Knebel Doeberitz, M, Loeffler, M, Rahner, N, Schröck, E, Steinke-Lange, V, Schmiegel, W, Vangala, D, Perne, C, Hüneburg, R, Redler, S, Büttner, R, Weitz, J, Pineda, M, Duenas, N, Vidal, J, Moreira, L, Sánchez, A, Hovig, E, Nakken, S, Green, K, Lalloo, F, Hill, J, Crosbie, E, Mints, M, Goldberg, Y, Dominguez-Valentin M., Haupt S., Seppälä T. T., Sampson J. R., Sunde L., Bernstein I., Jenkins M. A., Engel C., Aretz S., Nielsen M., Capella G., Balaguer F., Evans D. G., Burn J., Holinski-Feder E., Bertario L., Bonanni B., Lindblom A., Levi Z., Macrae F., Winship I., Plazzer J. P., Sijmons R., Laghi L., Della Valle A., Heinimann K., Dębniak T., Fruscio R., Lopez-Koestner F., Alvarez-Valenzuela K., Katz L. H., Laish I., Vainer E., Vaccaro C., Carraro D. M., Monahan K., Half E., Stakelum A., Winter D., Kennelly R., Gluck N., Sheth H., Abu-Freha N., Greenblatt M., Rossi B. M., Bohorquez M., Cavestro G. M., Lino-Silva L. S., Horisberger K., Tibiletti M. G., Nascimento I. d., Thomas H., Rossi N. T., Apolinário da Silva L., Zaránd A., Ruiz-Bañobre J., Heuveline V., Mecklin J. P., Pylvänäinen K., Renkonen-Sinisalo L., Lepistö A., Peltomäki P., Therkildsen C., Madsen M. G., Burgdorf S. K., Hopper J. L., Win A. K., Haile R. W., Lindor N., Gallinger S., Le Marchand L., Newcomb P. A., Figueiredo J., Buchanan D. D., Thibodeau S. N., von Knebel Doeberitz M., Loeffler M., Rahner N., Schröck E., Steinke-Lange V., Schmiegel W., Vangala D., Perne C., Hüneburg R., Redler S., Büttner R., Weitz J., Pineda M., Duenas N., Vidal J. B., Moreira L., Sánchez A., Hovig E., Nakken S., Green K., Lalloo F., Hill J., Crosbie E., Mints M., Goldberg Y., Dominguez-Valentin, M, Haupt, S, Seppälä, T, Sampson, J, Sunde, L, Bernstein, I, Jenkins, M, Engel, C, Aretz, S, Nielsen, M, Capella, G, Balaguer, F, Evans, D, Burn, J, Holinski-Feder, E, Bertario, L, Bonanni, B, Lindblom, A, Levi, Z, Macrae, F, Winship, I, Plazzer, J, Sijmons, R, Laghi, L, Della Valle, A, Heinimann, K, Dębniak, T, Fruscio, R, Lopez-Koestner, F, Alvarez-Valenzuela, K, Katz, L, Laish, I, Vainer, E, Vaccaro, C, Carraro, D, Monahan, K, Half, E, Stakelum, A, Winter, D, Kennelly, R, Gluck, N, Sheth, H, Abu-Freha, N, Greenblatt, M, Rossi, B, Bohorquez, M, Cavestro, G, Lino-Silva, L, Horisberger, K, Tibiletti, M, Nascimento, I, Thomas, H, Rossi, N, Apolinário da Silva, L, Zaránd, A, Ruiz-Bañobre, J, Heuveline, V, Mecklin, J, Pylvänäinen, K, Renkonen-Sinisalo, L, Lepistö, A, Peltomäki, P, Therkildsen, C, Madsen, M, Burgdorf, S, Hopper, J, Win, A, Haile, R, Lindor, N, Gallinger, S, Le Marchand, L, Newcomb, P, Figueiredo, J, Buchanan, D, Thibodeau, S, von Knebel Doeberitz, M, Loeffler, M, Rahner, N, Schröck, E, Steinke-Lange, V, Schmiegel, W, Vangala, D, Perne, C, Hüneburg, R, Redler, S, Büttner, R, Weitz, J, Pineda, M, Duenas, N, Vidal, J, Moreira, L, Sánchez, A, Hovig, E, Nakken, S, Green, K, Lalloo, F, Hill, J, Crosbie, E, Mints, M, Goldberg, Y, Dominguez-Valentin M., Haupt S., Seppälä T. T., Sampson J. R., Sunde L., Bernstein I., Jenkins M. A., Engel C., Aretz S., Nielsen M., Capella G., Balaguer F., Evans D. G., Burn J., Holinski-Feder E., Bertario L., Bonanni B., Lindblom A., Levi Z., Macrae F., Winship I., Plazzer J. P., Sijmons R., Laghi L., Della Valle A., Heinimann K., Dębniak T., Fruscio R., Lopez-Koestner F., Alvarez-Valenzuela K., Katz L. H., Laish I., Vainer E., Vaccaro C., Carraro D. M., Monahan K., Half E., Stakelum A., Winter D., Kennelly R., Gluck N., Sheth H., Abu-Freha N., Greenblatt M., Rossi B. M., Bohorquez M., Cavestro G. M., Lino-Silva L. S., Horisberger K., Tibiletti M. G., Nascimento I. d., Thomas H., Rossi N. T., Apolinário da Silva L., Zaránd A., Ruiz-Bañobre J., Heuveline V., Mecklin J. P., Pylvänäinen K., Renkonen-Sinisalo L., Lepistö A., Peltomäki P., Therkildsen C., Madsen M. G., Burgdorf S. K., Hopper J. L., Win A. K., Haile R. W., Lindor N., Gallinger S., Le Marchand L., Newcomb P. A., Figueiredo J., Buchanan D. D., Thibodeau S. N., von Knebel Doeberitz M., Loeffler M., Rahner N., Schröck E., Steinke-Lange V., Schmiegel W., Vangala D., Perne C., Hüneburg R., Redler S., Büttner R., Weitz J., Pineda M., Duenas N., Vidal J. B., Moreira L., Sánchez A., Hovig E., Nakken S., Green K., Lalloo F., Hill J., Crosbie E., Mints M., and Goldberg Y.

Abstract

Background: The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who are receiving medical follow-up, including colonoscopy surveillance, which aims to the achieve early diagnosis and treatment of cancers. Here we use the most recent PLSD cohort that is larger and has wider geographical representation than previous versions, allowing us to present mortality as an outcome, and median ages at cancer diagnoses for the first time. Methods: The PLSD is a prospective observational study without a control group that was designed in 2012 and updated up to October 2022. Data for 8500 carriers of path_MMR variants from 25 countries were included, providing 71,713 years of follow up. Cumulative cancer incidences at 65 years of age were combined with 10-year crude survival following cancer, to derive estimates of mortality up to 75 years of age by organ, gene, and gender. Findings: Gynaecological cancers were more frequent than colorectal cancers in path_MSH2, path_MSH6 and path_PMS2 carriers [cumulative incidence: 53.3%, 49.6% and 23.3% at 75 years, respectively]. Endometrial, colon and ovarian cancer had low mortality [8%, 13% and 15%, respectively] and prostate cancers were frequent in male path_MSH2 carriers [cumulative incidence: 39.7% at 75 years]. Pancreatic, brain, biliary tract and ureter and kidney and urinary bladder cancers were associated with high mortality [83%, 66%, 58%, 27%, and 29%, respectively]. Among path_MMR carriers undergoing colonoscopy surveillance, particularly path_MSH2 carriers, more deaths followed non-colorectal Lynch syndrome cancers than colorectal cancers. Interpretation: In path_MMR carriers undergoing colonoscopy surveillance, non-colorectal Lynch syndrome cancers were associated with more deaths than were colorectal cancers. Reducing deaths from non-colorectal cancers presents a key challenge in contemporary medical care in Lynch syndrome. Funding: We ackno

Published
2023

8. The WID-EC test for the detection and risk prediction of endometrial cancer

Author

Barrett, J, Jones, A, Evans, I, Herzog, C, Reisel, D, Olaitan, A, Mould, T, Macdonald, N, Doufekas, K, Newton, C, Crosbie, E, Bjorge, L, Colombo, N, Dostalek, L, Costas, L, Peremiquel-Trillas, P, Ponce, J, Matias-Guiu, X, Zikan, M, Cibula, D, Wang, J, Sundstrom, K, Dillner, J, Widschwendter, M, Barrett J. E., Jones A., Evans I., Herzog C., Reisel D., Olaitan A., Mould T., MacDonald N., Doufekas K., Newton C., Crosbie E. J., Bjorge L., Colombo N., Dostalek L., Costas L., Peremiquel-Trillas P., Ponce J., Matias-Guiu X., Zikan M., Cibula D., Wang J., Sundstrom K., Dillner J., Widschwendter M., Barrett, J, Jones, A, Evans, I, Herzog, C, Reisel, D, Olaitan, A, Mould, T, Macdonald, N, Doufekas, K, Newton, C, Crosbie, E, Bjorge, L, Colombo, N, Dostalek, L, Costas, L, Peremiquel-Trillas, P, Ponce, J, Matias-Guiu, X, Zikan, M, Cibula, D, Wang, J, Sundstrom, K, Dillner, J, Widschwendter, M, Barrett J. E., Jones A., Evans I., Herzog C., Reisel D., Olaitan A., Mould T., MacDonald N., Doufekas K., Newton C., Crosbie E. J., Bjorge L., Colombo N., Dostalek L., Costas L., Peremiquel-Trillas P., Ponce J., Matias-Guiu X., Zikan M., Cibula D., Wang J., Sundstrom K., Dillner J., and Widschwendter M.

Abstract

The incidence of endometrial cancer is rising. Measures to identify women at risk and to detect endometrial cancer earlier are required to reduce the morbidity triggered by the aggressive treatment required for advanced endometrial cancer. We developed the WID-EC (Women's cancer risk IDentification-Endometrial Cancer) test, which is based on DNA methylation at 500 CpG sites, in a discovery set of cervical liquid-based cytology samples from 1086 women with and without an endometrial cancer (217 cancer cases and 869 healthy controls) with a worse prognosis (grade 3 or ≥stage IB). We validated the WID-EC test in an independent external validation set of 64 endometrial cancer cases and 225 controls. We further validated the test in 150 healthy women (prospective set) who provided a cervical sample as part of the routine Swedish cervical screening programme, 54 of whom developed endometrial cancer within 3 years of sample collection. The WID-EC test identified women with endometrial cancer with a receiver operator characteristic area under the curve (AUC) of 0.92 (95% CI: 0.88-0.97) in the external set and of 0.82 (95% CI: 0.74-0.89) in the prospective validation set. Using an optimal cutoff, cancer cases were detected with a sensitivity of 86% and a specificity of 90% in the external validation set, and a sensitivity and specificity of 52% and 98% respectively in the prospective validation set. The WID-EC test can identify women with or at risk of endometrial cancer.

Published
2023

12. Boundary Layer Structures Over the Northwest Atlantic Derived From Airborne High Spectral Resolution Lidar and Dropsonde Measurements During the ACTIVATE Campaign.

Author

Xu, Y., Mitchell, B., Delgado, R., Ouyed, A., Crosbie, E., Cutler, L., Fenn, M., Ferrare, R., Hair, J., Hostetler, C., Kirschler, S., Kleb, M., Nehrir, A., Painemal, D., Robinson, C. E., Scarino, A. J., Shingler, T., Shook, M. A., Sorooshian, A., and Thornhill, K. L.

Subjects
BOUNDARY layer (Aerodynamics), ATMOSPHERIC boundary layer, LIDAR, OCEAN-atmosphere interaction, BACKSCATTERING, MIXING height (Atmospheric chemistry), ATMOSPHERIC water vapor measurement
Abstract

The Planetary Boundary Layer height (PBLH) is essential for studying PBL and ocean‐atmosphere interactions. Marine PBL is usually defined to include a mixed layer (ML) and a capping inversion layer. The ML height (MLH) estimated from the measurements of aerosol backscatter by a lidar was usually compared with PBLH determined from radiosondes/dropsondes in the past, as the PBLH is usually similar to MLH in nature. However, PBLH can be much greater than MLH for decoupled PBL. Here we evaluate the retrieved MLH from an airborne lidar (HSRL‐2) by utilizing 506 co‐located dropsondes during the ACTIVATE field campaign over the Northwest Atlantic from 2020 to 2022. First, we define and determine the MLH and PBLH from the temperature and humidity profiles of each dropsonde, and find that the MLH values from HSRL‐2 and dropsondes agree well with each other, with a coefficient of determination of 0.66 and median difference of 18 m. In contrast, the HSRL‐2 MLH data do not correspond to dropsonde‐derived PBLH, with a median difference of −47 m. Therefore, we modify the current operational and automated HSRL‐2 wavelet‐based algorithm for PBLH retrieval, decreasing the median difference significantly to −8 m. Further data analysis indicates that these conclusions remain the same for cases with higher or lower cloud fractions, and for decoupled PBLs. These results demonstrate the potential of using HSRL‐2 aerosol backscatter data to estimate both marine MLH and PBLH and suggest that lidar‐derived MLH should be compared with radiosonde/dropsonde‐determined MLH (not PBLH) in general. Plain Language Summary: The Planetary Boundary Layer Height (PBLH) is essential for studying the lower atmosphere and its interaction with the surface. Usually, it contains a mixed layer (ML) with vertically well‐mixed (i.e., nearly constant) specific humidity and potential temperature. Over the ocean, the PBL is usually coupled (vertically well‐mixed) and the ML height (MLH) is usually close to PBLH, hence the MLH estimated from the measurements of aerosol backscatter by a lidar is traditionally compared with PBLH determined from radiosondes/dropsondes. However, when the PBL is decoupled (not vertically well mixed), the MLH differs from the PBLH. Here we used dropsondes' thermodynamic profile to evaluate the airborne High‐Spectral‐Resolution Lidar—Generation 2 (HSRL‐2) estimation of MLH and PBLH in airborne field campaign over the northwestern Atlantic (ACTIVATE) from 2020 to 2022. We show that the HSRL‐2 has excellent MLH estimation compared to the dropsondes. We also improved the HSRL‐2 estimation of PBLH. Further data analysis indicates that these conclusions remain the same for cases with different cloud fractions, and for decoupled PBLs. These results demonstrate the potential of using HSRL‐2 aerosol backscatter data to estimate both marine MLH and PBLH and suggest that lidar‐derived MLH should be compared with radiosonde/dropsonde‐determined MLH (not PBLH) in general. Key Points: Dropsondes over the northwest Atlantic are used to determine mixed layer height (MLH) and boundary layer height (PBLH)HSRL‐2 lidar MLH product compares well with dropsonde‐derived MLH but does not correspond to PBLH for decoupled PBLThe current operational HSRL‐2 algorithm is modified to include retrieval of the PBLH for decoupled PBL [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations

Author

Nebgen, D. R., Domchek, S. M., Kotsopoulos, J., de Hullu, J. A., Crosbie, E. J., Paramanandam, V. S., van Zanten, M. B., Norquist, B. M., Guise, T., Rozenberg, S., Kurian, A. W., Pederson, H. J., Yuksel, N., Michaelson-Cohen, R., Bober, S. L., da SilvaFilho, A. L., Johansen, N., Guidozzi, F., Evans, D. G., Menon, U., Kingsberg, S. A., Powell, C. B., Grandi, G., Marchetti, Claudia, Jacobson, M., Brennan, D. J., Hickey, M., Marchetti C. (ORCID:0000-0001-7098-8956), Nebgen, D. R., Domchek, S. M., Kotsopoulos, J., de Hullu, J. A., Crosbie, E. J., Paramanandam, V. S., van Zanten, M. B., Norquist, B. M., Guise, T., Rozenberg, S., Kurian, A. W., Pederson, H. J., Yuksel, N., Michaelson-Cohen, R., Bober, S. L., da SilvaFilho, A. L., Johansen, N., Guidozzi, F., Evans, D. G., Menon, U., Kingsberg, S. A., Powell, C. B., Grandi, G., Marchetti, Claudia, Jacobson, M., Brennan, D. J., Hickey, M., and Marchetti C. (ORCID:0000-0001-7098-8956)

Abstract

Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.

Published
2023

15. The coupling between tropical meteorology, aerosol lifecycle, convection, and radiation, during the Cloud, Aerosol and Monsoon Processes Philippines Experiment (CAMP2Ex)

Author

Reid, J. S., primary, Maring, H. B., additional, Narisma, G. T., additional, van den Heever, S., additional, Di Girolamo, L., additional, Ferrare, R., additional, Lawson, P., additional, Mace, G. G., additional, Simpas, J. B., additional, Tanelli, S., additional, Ziemba, L., additional, van Diedenhoven, B., additional, Bruintjes, R., additional, Bucholtz, A., additional, Cairns, B., additional, Cambaliza, M. O., additional, Chen, G., additional, Diskin, G. S., additional, Flynn, J. H., additional, Hostetler, C. A., additional, Holz, R. E., additional, Lang, T. J., additional, Schmidt, K. S., additional, Smith, G., additional, Sorooshian, A., additional, Thompson, E. J., additional, Thornhill, K. L., additional, Trepte, C., additional, Wang, J., additional, Woods, S., additional, Yoon, S., additional, Alexandrov, M., additional, Alvarez, S., additional, Amiot, C. G., additional, Bennett, J. R., additional, Brooks, M.,, additional, Burton, S. P., additional, Cayanan, E., additional, Chen, H., additional, Collow, A., additional, Crosbie, E., additional, DaSilva, A., additional, DiGangi, J. P., additional, Flagg, D. D., additional, Freeman, S. W., additional, Fu, D., additional, Fukada, E., additional, Hilario, M. R. A., additional, Hong, Y., additional, Hristova-Veleva, S. M., additional, Kuehn, R., additional, Kowch, R. S., additional, Leung, G. R., additional, Loveridge, J., additional, Meyer, K., additional, Miller, R. M., additional, Montes, M. J., additional, Moum, J. N., additional, Nenes, Thanos, additional, Nesbitt, S. W., additional, Norgren, M., additional, Nowottnick, E. P., additional, Rauber, R. M., additional, Reid, E. A., additional, Rutledge, S., additional, Schlosser, J. S., additional, Sekiyama, T. T., additional, Shook, M. A., additional, Sokolowsky, G. A., additional, Stamnes, S. A., additional, Tanaka, T. Y., additional, Wasilewski, A., additional, Xian, P., additional, Xiao, Q., additional, Xu, Zhuocan, additional, and Zavaleta, J., additional

Published
2023
Full Text
View/download PDF

16. T.02.1 DELPHI INITIATIVE FOR EARLY-ONSET COLORECTAL CANCER (DIRECT): INTERNATIONAL MANAGEMENT GUIDELINES

Author

Cavestro, G.M., primary, Mannucci, A., additional, Balaguer, F., additional, Heather, H., additional, Kupfer, S., additional, Repici, A., additional, Sartore-Bianchi, A., additional, Seppala, T., additional, Valentini, V., additional, Boland, C., additional, Brand, R., additional, Buffart, T., additional, Burke, C., additional, Caccialanza, R., additional, Cannizzaro, R., additional, Cascinu, S., additional, Cercek, A., additional, Crosbie, E., additional, Danese, S., additional, Dekker, E., additional, Daca-Alvarez, M., additional, Deni, F., additional, Latchford, A., additional, Liska, D., additional, Lynch, P., additional, Malesci, A., additional, Mauri, G., additional, Meldolesi, E., additional, Pal, M., additional, Monahan, K., additional, Moslein, G., additional, Murphy, C., additional, Nass, K., additional, Ng, K., additional, Oliani, C., additional, Papaleo, E., additional, Patel, S., additional, Puzzono, M., additional, Remo, A., additional, Ricciardiello, L., additional, Ripamonti, C., additional, Siena, S., additional, Singh, S., additional, Stadler, Z., additional, Stanich, P., additional, Syngal, S., additional, Turi, S., additional, Urso, E., additional, Valle, L., additional, Vanni, V., additional, Vilar, E., additional, Vitellaro, M., additional, You, Y., additional, Yurgelun, M., additional, Zuppardo, R., additional, and Stoffel, E., additional

Published
2023
Full Text
View/download PDF

20. The public health playbook: ideas for challenging the corporate playbook.

Author

Lacy-Nichols, J, Marten, R, Crosbie, E, Moodie, R, Lacy-Nichols, J, Marten, R, Crosbie, E, and Moodie, R

Abstract

Many commercial actors use a range of coordinated and sophisticated strategies to protect business interests-their corporate playbook-but many of these strategies come at the expense of public health. To counter this corporate playbook and advance health and wellbeing, public health actors need to develop, refine, and modernise their own set of strategies, to create a public health playbook. In this Viewpoint, we seek to consolidate thinking around how public health can counter and proactively minimise powerful commercial influences. We propose an initial eight strategies for this public health playbook: expand public health training and coalitions, increase public sector resources, link with and learn from social movements to foster collective solidarity, protect public health advocates from industry threats, develop and implement rigorous conflict of interest safeguards, monitor and expose corporate activities, debunk corporate arguments, and leverage diverse commercial interests. This set of strategies seeks to amplify inherent assets of the public health community and create opportunities to explicitly counter the corporate playbook. These strategies are not exhaustive, and our aim is to provoke further discussion on and exploration of this topic. TRANSLATION: For the Spanish translation of this paper see Supplementary Materials section.

Published
2022

21. p53 immunohistochemistry in endometrial cancer:clinical and molecular correlates in the PORTEC-3 trial

Author

Vermij, Lisa, Léon-Castillo, Alicia, Singh, Naveena, Powell, M. E., Edmondson, Richard J., Genestie, Catherine, Khaw, Pearly, Pyman, Jan, McLachlin, C. Meg, Ghatage, Prafull, de Boer, Stephanie M., Nijman, H. W., Smit, V. T.H.B.M., Crosbie, Emma J., Leary, Alexandra, Creutzberg, Carien L., Horeweg, Nanda, Bosse, Tjalling, de Boer, S. M., Creutzberg, C. L., Bosse, T., Kroep, J., Nout, R. A., de Bruyn, M., Singh, N., Kitchener, H. C., Crosbie, E., Edmondson, R., Church, D. N., Leary, A., Mileshkin, L., Pollock, P. M., MacKay, H., Vermij, Lisa, Léon-Castillo, Alicia, Singh, Naveena, Powell, M. E., Edmondson, Richard J., Genestie, Catherine, Khaw, Pearly, Pyman, Jan, McLachlin, C. Meg, Ghatage, Prafull, de Boer, Stephanie M., Nijman, H. W., Smit, V. T.H.B.M., Crosbie, Emma J., Leary, Alexandra, Creutzberg, Carien L., Horeweg, Nanda, Bosse, Tjalling, de Boer, S. M., Creutzberg, C. L., Bosse, T., Kroep, J., Nout, R. A., de Bruyn, M., Singh, N., Kitchener, H. C., Crosbie, E., Edmondson, R., Church, D. N., Leary, A., Mileshkin, L., Pollock, P. M., and MacKay, H.

Abstract

Standard molecular classification of endometrial cancers (EC) is now endorsed by the WHO and identifies p53-abnormal (p53abn) EC as the subgroup with the poorest prognosis and the most likely to benefit from adjuvant chemo(radio)therapy. P53abn EC are POLE wildtype, mismatch repair proficient and show abnormal immunohistochemical (IHC) staining for p53. Correct interpretation of routinely performed p53 IHC has therefore become of paramount importance. We aimed to comprehensively investigate abnormal p53 IHC patterns and their relation to clinicopathological and molecular features. Tumor material of 411 molecularly classified high-risk EC from consenting patients from the PORTEC-3 clinical trial were collected. p53 IHC was successful in 408 EC and was considered abnormal when the tumor showed a mutant expression pattern (including subclonal): overexpression, null or cytoplasmic. The presence of pathogenic mutations was determined by next generation sequencing (NGS). Abnormal p53 expression was observed in 131/408 (32%) tumors. The most common abnormal p53 IHC pattern was overexpression (n = 89, 68%), followed by null (n = 12, 9%) and cytoplasmic (n = 3, 2%). Subclonal abnormal p53 staining was observed in 27 cases (21%), which was frequently but not exclusively, associated with POLE mutations and/or MMRd (n = 22/27; p < 0.001). Agreement between p53 IHC and TP53 NGS was observed in 90.7%, resulting in a sensitivity and specificity of 83.6% and 94.3%, respectively. Excluding POLEmut and MMRd EC, as per the WHO-endorsed algorithm, increased the accuracy to 94.5% with sensitivity and specificity of 95.0% and 94.1%, respectively. Our data shows that awareness of the abnormal p53 IHC patterns are prerequisites for correct EC molecular classification. Subclonal abnormal p53 expression is a strong indicator for POLEmut and/or MMRd EC. No significant differences in clinical outcomes were observed among the abnormal p53 IHC patterns. Our data support use of the WHO-endo

Published
2022

22. Dilution of Boundary Layer Cloud Condensation Nucleus Concentrations by Free Tropospheric Entrainment During Marine Cold Air Outbreaks

Author

Tornow, F., primary, Ackerman, A. S., additional, Fridlind, A. M., additional, Cairns, B., additional, Crosbie, E. C., additional, Kirschler, S., additional, Moore, R. H., additional, Painemal, D., additional, Robinson, C. E., additional, Seethala, C., additional, Shook, M. A., additional, Voigt, C., additional, Winstead, E. L., additional, Ziemba, L. D., additional, Zuidema, P., additional, and Sorooshian, A., additional

Published
2022
Full Text
View/download PDF

26. Reconciling Assumptions in Bottom‐Up and Top‐Down Approaches for Estimating Aerosol Emission Rates From Wildland Fires Using Observations From FIREX‐AQ

Author

Wiggins, E. B., primary, Anderson, B. E., additional, Brown, M. D., additional, Campuzano‐Jost, P., additional, Chen, G., additional, Crawford, J., additional, Crosbie, E. C., additional, Dibb, J., additional, DiGangi, J. P., additional, Diskin, G. S., additional, Fenn, M., additional, Gallo, F., additional, Gargulinski, E. M., additional, Guo, H., additional, Hair, J. W., additional, Halliday, H. S., additional, Ichoku, C., additional, Jimenez, J. L., additional, Jordan, C. E., additional, Katich, J. M., additional, Nowak, J. B., additional, Perring, A. E., additional, Robinson, C. E., additional, Sanchez, K. J., additional, Schueneman, M., additional, Schwarz, J. P., additional, Shingler, T. J., additional, Shook, M. A., additional, Soja, A. J., additional, Stockwell, C. E., additional, Thornhill, K. L., additional, Travis, K. R., additional, Warneke, C., additional, Winstead, E. L., additional, Ziemba, L. D., additional, and Moore, R. H., additional

Published
2021
Full Text
View/download PDF

29. 397 Molecular profiling of NSMP high-risk endometrial cancers of the PORTEC-3 trial – prognostic refinement and druggable targets

Author

Vermij, L, primary, Powell, M, additional, Leon-Castillo, A, additional, De Boer, S, additional, Mileshkin, L, additional, Mackay, H, additional, Leary, A, additional, Nijman, HW, additional, Singh, N, additional, Pollock, P, additional, Bessette, P, additional, Haie-Meder, C, additional, Smit, V, additional, Edmondson, R, additional, Crosbie, E, additional, Nout, R, additional, Horeweg, N, additional, Creutzberg, CL, additional, and Bosse, T, additional

Published
2021
Full Text
View/download PDF

30. 595 Implementation of collaborative translational research (TransPORTEC) findings in an international endometrial cancer clinical trials program (RAINBO)

Author

Bosse, T, primary, Powell, M, additional, Crosbie, E, additional, Leary, A, additional, Kroep, J, additional, Han, K, additional, Mcalpine, J, additional, Horeweg, N, additional, De Boer, S, additional, De Bruyn, M, additional, Nout, R, additional, Smit, V, additional, Nijman, HW, additional, Singh, N, additional, Mackay, H, additional, Edmondson, R, additional, Mileshkin, L, additional, Church, D, additional, Kitchener, H, additional, and Creutzberg, CL, additional

Published
2021
Full Text
View/download PDF

33. Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch syndrome tumor spectrum

Author

Dominguez-Valentin M., Sampson J. R., Moller P., Seppala T. T., Plazzer J. -P., Nakken S., Engel C., Aretz S., Jenkins M. A., Sunde L., Bernstein I., Capella G., Balaguer F., Thomas H., Evans D. G., Burn J., Greenblatt M., Hovig E., Nielsen M., de Vos tot Nederveen Cappel W. H., Sijmons R. H., Bertario L., Tibiletti M. G., Cavestro G. M., Lindblom A., Valle A. D., Lopez-Kostner F., Gluck N., Katz L. H., Heinimann K., Vaccaro C. A., Buttner R., Gorgens H., Holinski-Feder E., Morak M., Holzapfel S., Huneburg R., von Knebel Doeberitz M., Loeffler M., Rahner N., Weitz J., Steinke-Lange V., ten Broeke S. W., Schmiegel W., Vangala D., Pylvanainen K., Renkonen-Sinisalo L., Hopper J. L., Win A. K., Haile R. W., Lindor N. M., Gallinger S., Le Marchand L., Newcomb P. A., Figueiredo J. C., Thibodeau S. N., Jensen L. H., Madsen M. B., Kroldrup L., Nilbert M., Moreira L., Sanchez A., Serra-Burriel M., Pineda M., Navarro M., Vidal J. B., Blanco I., Green K., Lalloo F., Crosbie E. J., Hill J., Denton O. G., Rodland E. A., Vasen H., Mints M., Neffa F., Esperon P., Alvarez K., Kariv R., Rosner G., Pinero T. A., Gonzalez M. L., Kalfayan P., Tjandra D., Winship I. M., Macrae F., Moslein G., Mecklin J. -P., Dominguez-Valentin, M., Sampson, J. R., Moller, P., Seppala, T. T., Plazzer, J. -P., Nakken, S., Engel, C., Aretz, S., Jenkins, M. A., Sunde, L., Bernstein, I., Capella, G., Balaguer, F., Thomas, H., Evans, D. G., Burn, J., Greenblatt, M., Hovig, E., Nielsen, M., de Vos tot Nederveen Cappel, W. H., Sijmons, R. H., Bertario, L., Tibiletti, M. G., Cavestro, G. M., Lindblom, A., Valle, A. D., Lopez-Kostner, F., Gluck, N., Katz, L. H., Heinimann, K., Vaccaro, C. A., Buttner, R., Gorgens, H., Holinski-Feder, E., Morak, M., Holzapfel, S., Huneburg, R., von Knebel Doeberitz, M., Loeffler, M., Rahner, N., Weitz, J., Steinke-Lange, V., ten Broeke, S. W., Schmiegel, W., Vangala, D., Pylvanainen, K., Renkonen-Sinisalo, L., Hopper, J. L., Win, A. K., Haile, R. W., Lindor, N. M., Gallinger, S., Le Marchand, L., Newcomb, P. A., Figueiredo, J. C., Thibodeau, S. N., Jensen, L. H., Madsen, M. B., Kroldrup, L., Nilbert, M., Moreira, L., Sanchez, A., Serra-Burriel, M., Pineda, M., Navarro, M., Vidal, J. B., Blanco, I., Green, K., Lalloo, F., Crosbie, E. J., Hill, J., Denton, O. G., Rodland, E. A., Vasen, H., Mints, M., Neffa, F., Esperon, P., Alvarez, K., Kariv, R., Rosner, G., Pinero, T. A., Gonzalez, M. L., Kalfayan, P., Tjandra, D., Winship, I. M., Macrae, F., Moslein, G., and Mecklin, J. -P.

Subjects
Male, Adult, Oncology, Cancer Research, 2019-20 coronavirus outbreak, medicine.medical_specialty, sarcoma, Databases, Factual, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Sarcoma/diagnosis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Medicine, Aged, business.industry, Sarcoma, Syndrome, Middle Aged, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, Lynch syndrome, MSH2, 030220 oncology & carcinogenesis, Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis, Female, 030211 gastroenterology & hepatology, business
Published
2020
Full Text
View/download PDF

34. Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database (Genetics in Medicine, (2020), 22, 1, (15-25), 10.1038/s41436-019-0596-9)

Author

Dominguez-Valentin M., Sampson J. R., Seppala T. T., ten Broeke S. W., Plazzer J. -P., Nakken S., Engel C., Aretz S., Jenkins M. A., Sunde L., Bernstein I., Capella G., Balaguer F., Thomas H., Evans D. G., Burn J., Greenblatt M., Hovig E., de Vos tot Nederveen Cappel W. H., Sijmons R. H., Bertario L., Tibiletti M. G., Cavestro G. M., Lindblom A., Della Valle A., Lopez-Kostner F., Gluck N., Katz L. H., Heinimann K., Vaccaro C. A., Buttner R., Gorgens H., Holinski-Feder E., Morak M., Holzapfel S., Huneburg R., Knebel Doeberitz M., Loeffler M., Rahner N., Schackert H. K., Steinke-Lange V., Schmiegel W., Vangala D., Pylvanainen K., Renkonen-Sinisalo L., Hopper J. L., Win A. K., Haile R. W., Lindor N. M., Gallinger S., Le Marchand L., Newcomb P. A., Figueiredo J. C., Thibodeau S. N., Wadt K., Therkildsen C., Okkels H., Ketabi Z., Moreira L., Sanchez A., Serra-Burriel M., Pineda M., Navarro M., Blanco I., Green K., Lalloo F., Crosbie E. J., Hill J., Denton O. G., Frayling I. M., Rodland E. A., Vasen H., Mints M., Neffa F., Esperon P., Alvarez K., Kariv R., Rosner G., Pinero T. A., Gonzalez M. L., Kalfayan P., Tjandra D., Winship I. M., Macrae F., Moslein G., Mecklin J. -P., Nielsen M., Moller P., Dominguez-Valentin, M., Sampson, J. R., Seppala, T. T., ten Broeke, S. W., Plazzer, J. -P., Nakken, S., Engel, C., Aretz, S., Jenkins, M. A., Sunde, L., Bernstein, I., Capella, G., Balaguer, F., Thomas, H., Evans, D. G., Burn, J., Greenblatt, M., Hovig, E., de Vos tot Nederveen Cappel, W. H., Sijmons, R. H., Bertario, L., Tibiletti, M. G., Cavestro, G. M., Lindblom, A., Della Valle, A., Lopez-Kostner, F., Gluck, N., Katz, L. H., Heinimann, K., Vaccaro, C. A., Buttner, R., Gorgens, H., Holinski-Feder, E., Morak, M., Holzapfel, S., Huneburg, R., Knebel Doeberitz, M., Loeffler, M., Rahner, N., Schackert, H. K., Steinke-Lange, V., Schmiegel, W., Vangala, D., Pylvanainen, K., Renkonen-Sinisalo, L., Hopper, J. L., Win, A. K., Haile, R. W., Lindor, N. M., Gallinger, S., Le Marchand, L., Newcomb, P. A., Figueiredo, J. C., Thibodeau, S. N., Wadt, K., Therkildsen, C., Okkels, H., Ketabi, Z., Moreira, L., Sanchez, A., Serra-Burriel, M., Pineda, M., Navarro, M., Blanco, I., Green, K., Lalloo, F., Crosbie, E. J., Hill, J., Denton, O. G., Frayling, I. M., Rodland, E. A., Vasen, H., Mints, M., Neffa, F., Esperon, P., Alvarez, K., Kariv, R., Rosner, G., Pinero, T. A., Gonzalez, M. L., Kalfayan, P., Tjandra, D., Winship, I. M., Macrae, F., Moslein, G., Mecklin, J. -P., Nielsen, M., and Moller, P.

Abstract

The original version of this Article did not contain details of Dutch Cancer Society (DCS) funding (grant number UL 2017-8223) in the Acknowledgements section. This has now been corrected in both the PDF and HTML versions of the Article.

Published
2020

37. Spaces of well-being and regional settlement: International migrants and the rural idyll

Author

Klocker, N, Hodge, P, Dun, O, Crosbie, E, Dufty-Jones, R, McMichael, C, Block, K, Piper, M, Musoni, E, Ford, L, Jordan, C, Radford, D, Klocker, N, Hodge, P, Dun, O, Crosbie, E, Dufty-Jones, R, McMichael, C, Block, K, Piper, M, Musoni, E, Ford, L, Jordan, C, and Radford, D

Abstract

Regionalisation is a hallmark of Australia's approach to international migration, reflecting governments' growing concern with where new arrivals live. Residence in regional Australia is encouraged (mandated, for some visas) in response to urban population pressures alongside rural population and economic decline. Parallel to regionally focused visa schemes exists a pattern of voluntary urban‐to‐rural migration among some international migrants. Such secondary mobility counters the policy logic that international migrants only live outside cities when required to do so. This paper explores 18 African migrants' motivations for ‘urban flight’: Australian cities have failed to sustain their well‐being and they consider rural life a remedy. Their preference for rural locations is not purely instrumental, it is shaped by deep‐seated affective connections. Given the challenges of regional population retention, settlement policies should be recalibrated to support the aspirations of international migrants who feel an affinity for rural places, rather than compelling the rural settlement of others who do not.

Published
2021

43. Molecular classification of the PORTEC-3 trial for high-risk endometrial cancer: Impact on adjuvant therapy

Author

Creutzberg, C. L., Leon-Castillo, A., de Boer, S. M., Powell, M. E., Mileshkin, L. R., Mackay, H. J., Leary, A., Nijman, H. W., Singh, N., Pollock, P., Fyles, A., Haie-Meder, C., Smit, V. T. H. B. M., Edmondson, R. J., Putter, H., Kitchener, H. C., Crosbie, E. J., de Bruyn, M., Nout, R., Bosse, T., Targeted Gynaecologic Oncology (TARGON), and Translational Immunology Groningen (TRIGR)

Published
2019

44. Becoming Reading Group: reflections on assembling a collegiate, caring collective

Author

Ey, M, Mee, K, Allison, J, Caves, S, Crosbie, E, Hughes, A, Curtis, F, Doney, R, Dunstan, P, Jones, R, Tyndall, A, Baker, T, Cameron, J, Duffy, M, Dufty-Jones, R, Dunn, K, Hodge, P, Kearnes, M ; https://orcid.org/0000-0001-6267-9571, McGuirk, P, O’Neill, P, Ruming, K, Sherval, M, Williams, M, Wright, S, Ey, M, Mee, K, Allison, J, Caves, S, Crosbie, E, Hughes, A, Curtis, F, Doney, R, Dunstan, P, Jones, R, Tyndall, A, Baker, T, Cameron, J, Duffy, M, Dufty-Jones, R, Dunn, K, Hodge, P, Kearnes, M ; https://orcid.org/0000-0001-6267-9571, McGuirk, P, O’Neill, P, Ruming, K, Sherval, M, Williams, M, and Wright, S

Abstract

In neoliberalising universities, collegial and collective practices such as reading groups are often positioned by students, staff and managers as less important than meeting individual KPIs (such as producing research publications, seeking research grants, or meeting the increasing demands of producing quality teaching outcomes.) However, reading groups can be vital for cultivating caring collectives and spaces of collegiality. In this paper we use assemblage thinking to explore 25 years of a Geography reading group at the University of Newcastle. The paper addresses two questions: what does reading together do and make possible; and how might we think about the labours of reading together as a way of building caring collectives. The paper draws on reflections from 24 past and present members of reading group to explore how these kinds of academic practices nourish our working lives.

Published
2020

45. Army aviation: on the move

Author

Gen. Saint, Crosbie E., Gen. Sinclair, E.J. Brig., and Maj. Gess, Jonathan O.

Subjects
United States. Army -- Management, Armed Forces -- Management, Aeronautics, Military -- Management, Company business management, Military and naval science
Abstract

The success achieved by the Operation Iraqi Freedom (OIF) in Iraq shows the potential for the Army Aviation in the joint environment for the future. Army Aviation is considered to be the capabilities-based maneuver arm that is optimized for the joint fight with the greatest potential of any branch.

Published
2004

46. Why Comanche?

Author

Richardson, William R. and Saint, Crosbie E.

Subjects
United States. Army -- Equipment and supplies, Attack helicopters -- Design and construction, Military and naval science, RAH-66 (Helicopter) -- Design and construction
Abstract

The RAH-66 Comanche is viewed as the next generation reconnaissance and attack helicopter. Although the initial design of the Comanche did not meet expectations and it is anticipated that some $3.4 billion will be spent correcting it.

Published
2002

47. The North Atlantic Aerosol and Marine Ecosystem Study (NAAMES): Science motive and mission overview

Author

Behrenfeld, MJ, Behrenfeld, MJ, Moore, RH, Hostetler, CA, Graff, J, Gaube, P, Russell, LM, Chen, G, Doney, SC, Giovannoni, S, Liu, H, Proctor, C, Bolaños, LM, Baetge, N, Davie-Martin, C, Westberry, TK, Bates, TS, Bell, TG, Bidle, KD, Boss, ES, Brooks, SD, Cairns, B, Carlson, C, Halsey, K, Harvey, EL, Hu, C, Karp-Boss, L, Kleb, M, Menden-Deuer, S, Morison, F, Quinn, PK, Scarino, AJ, Anderson, B, Chowdhary, J, Crosbie, E, Ferrare, R, Hair, JW, Hu, Y, Janz, S, Redemann, J, Saltzman, E, Shook, M, Siegel, DA, Wisthaler, A, Martin, MY, Ziemba, L, Behrenfeld, MJ, Behrenfeld, MJ, Moore, RH, Hostetler, CA, Graff, J, Gaube, P, Russell, LM, Chen, G, Doney, SC, Giovannoni, S, Liu, H, Proctor, C, Bolaños, LM, Baetge, N, Davie-Martin, C, Westberry, TK, Bates, TS, Bell, TG, Bidle, KD, Boss, ES, Brooks, SD, Cairns, B, Carlson, C, Halsey, K, Harvey, EL, Hu, C, Karp-Boss, L, Kleb, M, Menden-Deuer, S, Morison, F, Quinn, PK, Scarino, AJ, Anderson, B, Chowdhary, J, Crosbie, E, Ferrare, R, Hair, JW, Hu, Y, Janz, S, Redemann, J, Saltzman, E, Shook, M, Siegel, DA, Wisthaler, A, Martin, MY, and Ziemba, L

Abstract

The North Atlantic Aerosols and Marine Ecosystems Study (NAAMES) is an interdisciplinary investigation to improve understanding of Earth's ocean ecosystem-aerosol-cloud system. Specific overarching science objectives for NAAMES are to (1) characterize plankton ecosystem properties during primary phases of the annual cycle and their dependence on environmental forcings, (2) determine how these phases interact to recreate each year the conditions for an annual plankton bloom, and (3) resolve how remote marine aerosols and boundary layer clouds are influenced by plankton ecosystems. Four NAAMES field campaigns were conducted in the western subarctic Atlantic between November 2015 and April 2018, with each campaign targeting specific seasonal events in the annual plankton cycle. A broad diversity of measurements were collected during each campaign, including ship, aircraft, autonomous float and drifter, and satellite observations. Here, we present an overview of NAAMES science motives, experimental design, and measurements. We then briefly describe conditions and accomplishments during each of the four field campaigns and provide information on how to access NAAMES data. The intent of this manuscript is to familiarize the broad scientific community with NAAMES and to provide a common reference overview of the project for upcoming publications.

Published
2019

48. European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender.

Author

Seppälä, T. T., Latchford, A., Negoi, I., Soares, A. Sampaio, Jimenez-Rodriguez, R., Sánchez-Guillén, L., Evans, D. G., Ryan, N., Crosbie, E. J., Dominguez-Valentin, M., Burn, J., Kloor, M., Doeberitz, M. von Knebel, van Duijnhoven, F. J. B., Quirke, P., Sampson, J. R., Møller, P., and Möslein, G.

Subjects
HEREDITARY nonpolyposis colorectal cancer, COLORECTAL cancer, GENDER, DISEASE risk factors, DNA mismatch repair, GASTROENTEROLOGISTS
Abstract

Background: Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. Large prospective observational studies have recently increased understanding of the effectiveness of colonoscopic surveillance and the heterogeneity of cancer risk between genotypes. The need for gene- and gender-specific guidelines has been acknowledged. Methods: The European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP) developed a multidisciplinary working group consisting of surgeons, clinical and molecular geneticists, pathologists, epidemiologists, gastroenterologists, and patient representation to conduct a graded evidence review. The previous Mallorca guideline format was used to revise the clinical guidance. Consensus for the guidance statements was acquired by three Delphi voting rounds. Results: Recommendations for clinical and molecular identification of Lynch syndrome, surgical and endoscopic management of Lynch syndrome-associated colorectal cancer, and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum. Manchester consensus guidelines for gynaecological management were endorsed. Executive and layperson summaries were provided. Conclusion: The recommendations from the EHTG and ESCP for identification of patients with Lynch syndrome, colorectal surveillance, surgical management of colorectal cancer, lifestyle and chemoprevention in Lynch syndrome that reached a consensus (at least 80 per cent) are presented. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

49. Homozygous germ-line mutation of the PMS2 mismatch repair gene: a unique case report of constitutional mismatch repair deficiency (CMMRD)

Author

Ramchander, N. C., Ryan, N. A. J., Crosbie, E. J., and Evans, D. G.

Subjects
Adult, lcsh:Internal medicine, lcsh:QH426-470, DNA Mutational Analysis, Case Report, Mismatch repair, Neoplastic Syndromes, Hereditary, Genetics, Humans, Genetics(clinical), lcsh:RC31-1245, Germ-Line Mutation, Mismatch Repair Endonuclease PMS2, Base Sequence, Brain Neoplasms, Homozygote, Turcot syndrome, DNA, Exons, MMR, Colorectal Neoplasms, Hereditary Nonpolyposis, CMMRD, Pedigree, lcsh:Genetics, PMS2, Lynch syndrome, Female, Colorectal Neoplasms, Constitutional mismatch repair deficiency, Gene Deletion
Abstract

Background Constitutional mismatch repair deficiency syndrome results from bi-allelic inheritance of mutations affecting the key DNA mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. Individuals with bi-allelic mutations have a dysfunctional mismatch repair system from birth; as a result, constitutional mismatch repair deficiency syndrome is characterised by early onset malignancies. Fewer than 150 cases have been reported in the literature over the past 20 years. This is the first report of the founder PMS2 mutation - NM_000535.5:c.1500del (p.Val501TrpfsTer94) in exon 11 and its associated cancers in this family. Case presentation The proband is 30 years old and is alive today. She is of Pakistani ethnic origin and a product of consanguinity. She initially presented aged 24 with painless bleeding per-rectum from colorectal polyps and was referred to clinical genetics. Clinical examination revealed two café-au-lait lesions, lichen planus, and a dermoid cyst. Her sister had been diagnosed in childhood with an aggressive brain tumour followed by colorectal cancer. During follow up, the proband developed 37 colorectal adenomatous polyps, synchronous ovarian and endometrial adenocarcinomas, and ultimately a metachronous gastric adenocarcinoma. DNA sequencing of peripheral lymphocytes revealed a bi-allelic inheritance of the PMS2 mutation NM_000535.5:c.1500del (p.Val501TrpfsTer94) in exon 11. Ovarian tumour tissue demonstrated low microsatellite instability. To date, she has had a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and a total gastrectomy. Aspirin and oestrogen-only hormone replacement therapy provide some chemoprophylaxis and manage postmenopausal symptoms, respectively. An 18-monthly colonoscopy surveillance programme has led to the excision of three high-grade dysplastic colorectal tubular adenomatous polyps. The proband’s family pedigree displays multiple relatives with cancers including a likely case of ‘true’ Turcot syndrome. Conclusions Constitutional mismatch repair deficiency syndrome should be considered in patients who present with early onset cancer, a strong family history of cancer, and cutaneous features resembling neurofibromatosis type I. Immunohistochemistry analysis of tumour and normal tissue is sensitive and specific for identifying patients with mismatch repair deficiency and should direct DNA sequencing of lymphocytic tissue to establish a diagnosis. Microsatellite instability status appears to be of little value in identifying patients who may have constitutional mismatch repair deficiency syndrome.

Published
2017

50. A mismatch in care: results of a United Kingdom-wide patient and clinician survey of gynaecological services for women with Lynch syndrome.

Author

Ryan, NAJ, Nobes, M, Sedgewick, D, Teoh, S‐N, Evans, DG, Crosbie, EJ, Teoh, S-N, Evans, D G, and Crosbie, E J

Subjects
HEREDITARY nonpolyposis colorectal cancer, WOMEN'S programs, ONCOLOGISTS, PATIENT surveys, SUPPORT groups, ENDOMETRIAL cancer
Abstract

Objective: To describe the current testing practice, referral pathways and gynaecological services available to women with Lynch syndrome (LS) in the UK.Design: Cross-sectional nationwide survey of gynaecological oncologists and women with LS.Setting: United Kingdom.Methods: Gynaecological oncologists were contacted directly. Women with LS were identified from national and regional clinical databases and the patient support group, Lynch syndrome UK.Main Outcome Measures: Gynaecological oncologists were asked to report rates of LS testing and current practice regarding risk-reducing strategies and gynaecological surveillance for women with LS. Women with LS were asked to describe their experiences of gynaecological care.Results: In total, 41 gynaecological oncologists and 298 women with LS responded to the survey. Of the gynaecological oncologists surveyed, 37% were unfamiliar with any clinical guidelines for the management of LS. Only 29% of gynaecological oncologists supported universal testing of endometrial cancer for LS; one centre routinely performed such testing. In all, 83% said they perform risk-reducing gynaecological surgery and 43% were aware of a local gynaecological surveillance service for women with LS. Of women with LS, most had undergone a hysterectomy (n = 191/64.1%), most frequently to reduce their gynaecological cancer risk (n = 86/45%). A total of 10% were initially referred for LS testing by their gynaecologist and 55% of those eligible regularly attended gynaecological surveillance; however, 62% wanted more regular surveillance. Regional variation was evident across all standards of care.Conclusions: There is widespread variation in the services offered to women with LS in the UK. As a community, gynaecological oncologists should move towards a nationally agreed provision of services.Tweetable Abstract: A mismatch in care for mismatch repair. Survey finds significant variation in gynaecological care for #Lynchsyndrome in the UK. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results