Search

Your search keyword '"Cross, Kaitlyn"' showing total 32 results
Start Over Author "Cross, Kaitlyn"
32 results on '"Cross, Kaitlyn"'

1. Neurodevelopment in preschool children exposed and unexposed to Zika virus in utero in Nicaragua: a prospective cohort study.

Author

Max, Ryan, Toval-Ruiz, Christian, Becker-Dreps, Sylvia, Gajewski, Anna, Martinez, Evelin, Cross, Kaitlyn, Blette, Bryan, Ortega, Oscar, Collado, Damaris, Zepeda, Omar, Familiar, Itziar, Boivin, Michael, Chavarria, Meylin, Meléndez, María, Mercado, Juan, de Silva, Aravinda, Collins, Matthew, Westreich, Daniel, Bos, Sandra, Harris, Eva, Balmaseda, Angel, Gower, Emily, Bowman, Natalie, Stringer, Elizabeth, and Bucardo, Filemón

Subjects
Humans, Nicaragua, Zika Virus Infection, Female, Prospective Studies, Child, Preschool, Pregnancy, Male, Prenatal Exposure Delayed Effects, Infant, Pregnancy Complications, Infectious, Child Development, Zika Virus, Adult, Neurodevelopmental Disorders
Abstract

BACKGROUND: Data on long-term neurodevelopmental outcomes of normocephalic children (born with normal head circumference) exposed to Zika virus in utero are scarce. We aimed to compare neurodevelopmental outcomes in normocephalic children up to age 48 months with and without Zika virus exposure in utero. METHODS: In this prospective cohort study, we included infants from two cohorts of normocephalic children born in León and Managua, Nicaragua during the 2016 Zika epidemic. In León, all women pregnant during the two enrolment periods were eligible. In Managua, mother-child pairs were included from three districts in the municipality of Managua: all women who became pregnant before June 15, 2016, and had a due date of Sept 15, 2016 or later were eligible. Infants were serologically classified as Zika virus-exposed or Zika virus-unexposed in utero and were followed up prospectively until age 48 months. At 36 months and 48 months of age, the Mullen Scales of Early Learning (MSEL) assessment was administered. Primary outcomes were MSEL early learning composite (ELC) scores at 30-48 months in León and 36-48 months in Managua. We used an inverse probability weighting generalised estimating equations model to assess the effect of Zika virus exposure on individual MSEL cognitive domain scores and ELC scores, adjusted for maternal education and age, poverty status, and infant sex. FINDINGS: The initial enrolment period for the León cohort was between Jan 31 and April 5, 2017 and the second was between Aug 30, 2017, and Feb 22, 2018. The enrolment period for the Managua cohort was between Oct 24, 2019, and May 5, 2020. 478 mothers (482 infants) from the León cohort and 615 mothers (609 infants) from the Managua cohort were enrolled, of whom 622 children (303 from the León cohort; 319 from the Managua cohort) were included in the final analysis; four children had microcephaly at birth and thus were excluded from analyses, two from each cohort. 33 (11%) of 303 children enrolled in León and 219 (69%) of 319 children enrolled in Managua were exposed to Zika virus in utero. In both cohorts, no significant differences were identified in adjusted mean ELC scores between Zika virus-exposed and unexposed infants at 36 months (between-group difference 1·2 points [95% CI -4·2 to 6·5] in the León cohort; 2·8 [-2·4 to 8·1] in the Managua cohort) or at 48 months (-0·9 [-10·8 to 8·8] in the León cohort; 0·1 [-5·1 to 5·2] in the Managua cohort). No differences in ELC scores between Zika virus-exposed and unexposed infants exceeded 6 points at any time between 30 months and 48 months in León or between 36 months and 48 months in Managua, which was considered clinically significant in other settings. INTERPRETATION: We found no significant differences in neurodevelopmental scores between normocephalic children with in-utero Zika virus exposure and Zika virus-unexposed children at age 36 months or 48 months. These findings are promising, supporting typical neurodevelopment in Zika virus-exposed normocephalic children, although additional follow-up and research is warranted. FUNDING: National Institute of Child Health and Development, National Institute of Allergy and Infectious Diseases, and Fogarty International Center. TRANSLATION: For the Spanish translation of the abstract see Supplementary Materials section.

Published
2024

2. Baricitinib Treatment of Coronavirus Disease 2019 Is Associated With a Reduction in Secondary Infections

Author

Sweeney, Daniel A, Tuyishimire, Bonifride, Ahuja, Neera, Beigel, John H, Beresnev, Tatiana, Cantos, Valeria D, Castro, Jose G, Cohen, Stuart H, Cross, Kaitlyn, Dodd, Lori E, Erdmann, Nathan, Fung, Monica, Ghazaryan, Varduhi, George, Sarah L, Grimes, Kevin A, Hynes, Noreen A, Julian, Kathleen G, Kandiah, Sheetal, Kim, Hannah Jang, Levine, Corri B, Lindholm, David A, Lye, David C, Maves, Ryan C, Oh, Myoung-Don, Paules, Catharine, Rapaka, Rekha R, Short, Willam R, Tomashek, Kay M, Wolfe, Cameron R, and Kalil, Andre C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Clinical Trials and Supportive Activities, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, baricitinib, COVID-19, secondary infections, Clinical sciences, Medical microbiology
Abstract

We performed a secondary analysis of the National Institutes of Health-sponsored Adaptive COVID-19 Treatment Trial (ACTT-2) randomized controlled trial and found that baricitinib was associated with a 50% reduction in secondary infections after controlling for baseline and postrandomization patient characteristics. This finding provides a novel mechanism of benefit for baricitinib and supports the safety profile of this immunomodulator for the treatment of coronavirus disease 2019.

Published
2023

3. Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge one year later

Author

Milligan, Emma C, Olstad, Katherine, Williams, Caitlin A, Mallory, Michael, Cano, Patricio, Cross, Kaitlyn A, Munt, Jennifer E, Garrido, Carolina, Lindesmith, Lisa, Watanabe, Jennifer, Usachenko, Jodie L, Hopkins, Lincoln, Immareddy, Ramya, Lakshmanappa, Yashavanth Shaan, Elizaldi, Sonny R, Roh, Jamin W, Sammak, Rebecca L, Pollard, Rachel E, Yee, JoAnn L, Herbek, Savannah, Scobey, Trevor, Miehlke, Dieter, Fouda, Genevieve, Ferrari, Guido, Gao, Hongmei, Shen, Xiaoying, Kozlowski, Pamela A, Montefiori, David, Hudgens, Michael G, Edwards, Darin K, Carfi, Andrea, Corbett, Kizzmekia S, Graham, Barney S, Fox, Christopher B, Tomai, Mark, Iyer, Smita S, Baric, Ralph, Reader, Rachel, Dittmer, Dirk P, Van Rompay, Koen KA, Permar, Sallie R, and De Paris, Kristina

Subjects
Immunization, Emerging Infectious Diseases, Infectious Diseases, Prevention, Biodefense, Vaccine Related, Pneumonia, Pneumonia & Influenza, Lung, Biotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Prevention of disease and conditions, and promotion of well-being, 3.4 Vaccines, Infection, Good Health and Well Being, Animals, Humans, Infant, SARS-CoV-2, COVID-19 Vaccines, Macaca mulatta, COVID-19, Viral Vaccines, BNT162 Vaccine, Antibodies, Viral, Antibodies, Neutralizing, Biological Sciences, Medical and Health Sciences
Abstract

The U.S. Food and Drug Administration only gave emergency use authorization of the BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines for infants 6 months and older in June 2022. Yet questions regarding the durability of vaccine efficacy, especially against emerging variants, in this age group remain. We demonstrated previously that a two-dose regimen of stabilized prefusion Washington SARS-CoV-2 S-2P spike (S) protein encoded by mRNA encapsulated in lipid nanoparticles (mRNA-LNP) or purified S-2P mixed with 3M-052, a synthetic Toll-like receptor (TLR) 7/8 agonist, in a squalene emulsion (Protein+3M-052-SE) was safe and immunogenic in infant rhesus macaques. Here, we demonstrate that broadly neutralizing and spike-binding antibodies against variants of concern (VOCs), as well as T cell responses, persisted for 12 months. At 1 year, corresponding to human toddler age, we challenged vaccinated rhesus macaques and age-matched nonvaccinated controls intranasally and intratracheally with a high dose of heterologous SARS-CoV-2 B.1.617.2 (Delta). Seven of eight control rhesus macaques exhibited severe interstitial pneumonia and high virus replication in the upper and lower respiratory tract. In contrast, vaccinated rhesus macaques had faster viral clearance with mild to no pneumonia. Neutralizing and binding antibody responses to the B.1.617.2 variant at the day of challenge correlated with lung pathology and reduced virus replication. Overall, the Protein+3M-052-SE vaccine provided superior protection to the mRNA-LNP vaccine, emphasizing opportunities for optimization of current vaccine platforms. The observed efficacy of both vaccines 1 year after vaccination supports the implementation of an early-life SARS-CoV-2 vaccine.

Published
2023

4. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials

Author

Hermine, Olivier, Mariette, Xavier, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Resche-Rigon, Matthieu, Tharaux, Pierre-Louis, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Porcher, Raphaël, Pourchet-Martinez, Valerie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Raked, Nabil, Mameri, Lakhdar, Montlahuc, Claire, Biard, Lucie, Alary, St.phanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Charreteur, Robin, Dupre, Céline, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Pavy, Stephan, Nocturne, Gaétane, Bitoun, Samuel, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stephane, Baudry, Elodie, Verny, Christiane, Lefevre, Edouard, Zaidan, Mohamad, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Grimaldi, Lamiae, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Soléne, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Le Tiec, Clotilde, Verstuyft, Céline, Roques, Anne-Marie, Georgin-Lavialle, Sophie, Senet, Patricia, Pialoux, Gilles, Soria, Angele, Parrot, Antoine, François, Helene, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadege, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefévre, Guillaume, Gottenberg, Jacques-Eric, Hansmann, Yves, Blanc, Frédéric, Ohlmann-Caillard, Sophie, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurelien, Heger, Bob, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Mertes, Paul-Michel, Noll, Eric, Oberlin, Mathieu, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Weill, François, Meyer, Nicolas, Andres, Emmanuel, Demonsant, Eric, Tayebi, Hakim, Nisand, Gabriel, Brin, Stéphane, Sublon, Cédric, Becker, Guillaume, Hutt, Anne, Martin, Tristan, Bayer, Sophie, Metzger, Catherine, Mekinian, Arsene, Abisror, Noémie, Adedjouma, Amir, Bollens, Diane, Bonneton, Marion, Bourcicaux, Nathalie, Bourrier, Anne, Thibault Chiarabiani, Maria Chauchard, Chopin, Doroth.e, Cohen, Jonathan, Devred, Ines, Donadille, Bruno, Fain, Olivier, Hariri, Geoffrey, Jachiet, Vincent, Ingliz, Patrick, Garnier, Marc, Gatfosse, Marc, Ghrenassia, Etienne, Gobert, Delphine, Krause le Garrec, Jessica, Landman, Cecilia, Lavillegrand, Jean Remy, Lefebvre, Benedicte, Mahevas, Thibault, Mazerand, Sandie, Meynard, Jean Luc, Morgand, Marjolaine, Ouaz.ne, Zineb, Pacanowski, Jerome, Riviere, S.bastien, Seksik, Philippe, Sokol, Harry, Soliman, Heithem, Valin, Nadia, Urbina, Thomas, McAvoy, Chloé, Miranda, Maria Pereira, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Nguyen, Anne Daguenel, Girault, Elise, Mayala-Kanda, Cl.mentine, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean-Sébastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Pennet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Denis, Jesuthasan, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Val.rie, Tréhan, Anne, Vigna, Véronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charléne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, Xavier, Ghosn, Jade, Bachelard, Antoine, Rachline, Anne, Isernia, Valentina, Bao-chau, Phung, Vallois, Dorothée, Sautereau, Aurelie, Neukrich, Catherine, Dossier, Antoine, Borie, Raphaël, Crestani, Bruno, Ducrocq, Gregory, Steg, Philippe Gabriel, Dieude, Philippe, Papo, Thomas, Marcault, Estelle, Chaudhry, Marhaba, Da Silveira, Charléne, Metois, Annabelle, Mahenni, Ismahan, Meziani, Meriam, Nilusmas, Cyndie, Le Gac, Sylvie, Ndiaye, Awa, Louni, Fran.oise, Chansombat, Malikhone, Julia, Zelie, Chalal, Solaya, Chalal, Lynda, Kramer, Laura, Le Grand, Jeniffer, Ouifiya, Kafif, Piquard, Valentine, Tubiana, Sarah, Nguyen, Yann, Honsel, Vasco, Weiss, Emmanuel, Codorniu, Anais, Zarrouk, Virginie, de Lastours, Victoire, Uzzan, Matthieu, Gamany, Naura, Claveirole, Agathe, Navid, Alexandre, Fouque, Tiffanie, Cohen, Yonathan, Lupo, Maya, Gilles, Constance, Rahli, Roza, Louis, Zeina, Boutboul, David, Galicier, Lionel, Amara, Yaël, Archer, Gabrielle, Benattia, Amira, Bergeron, Anne, Bondeelle, Louise, de Castro, Nathalie, Clément, Melissa, Darmon, Michaël, Denis, Blandine, Dupin, Clairelyne, Feredj, Elsa, Feyeux, Delphine, Joseph, Adrien, Lenglin, Etienne, Le Guen, Pierre, Liégeon, Geoffroy, Lorillon, Gwenaël, Mabrouki, Asma, Mariotte, Eric, Martin de Frémont, Grégoire, Mirouse, Adrien, Molina, Jean-Michel, Peffault de Latour, Régis, Oksenhendler, Eric, Saussereau, Julien, Tazi, Abdellatif, Tudesq, Jean-Jacques, Zafrani, Lara, Brindele, Isabelle, Bugnet, Emmanuelle, Lebras, Karine Celli, Chabert, Julien, Djaghout, Lamia, Fauvaux, Catherine, Jegu, Anne Lise, Kozakiewicz, Ewa, Meunier, Martine, Tremorin, Marie-Thérèse, Davoine, Claire, Madelaine, Isabelle, Caillat-Zucman, Sophie, Delaugerre, Constance, Morin, Florence, Sène, Damien, Burlacu, Ruxandra, Chousterman, Benjamin, Mégarbanne, Bruno, Richette, Pascal, Riveline, Jean-Pierre, Frazier, Aline, Vicaut, Eric, Berton, Laure, Hadjam, Tassadit, Vazquez-Ibarra, Miguel Alejandro, Jourdaine, Clément, Tran, Olivia, Jouis, Véronique, Jacob, Aude, Smati, Julie, Renaud, Stéphane, Pernin, Claire, Suarez, Lydia, Semerano, Luca, Abad, Sébastien, nainous, Ruben B., Bonnet, Nicolas, Comparon, Celine, Cohen, Yves, Cordel, Hugues, Dhote, Robin, Dournon, Nathalie, Duchemann, Boris, Ebstein, Nathan, Gille, Thomas, Giroux-Leprieur, Benedicte, Goupil de Bouille, Jeanne, Nunes, Hilario, Oziel, Johanna, Roulot, Dominique, Sese, Lucile, ClaireTantet, Uzunhan, Yurdagul, Bloch-Queyrat, Coralie, Levy, Vincent, Messani, Fadhila, Rahaoui, Mohammed, Petit, Myléne, Brahmi, Sabrina, Rathoin, Vanessa, Rigal, Marthe, Costedoat-Chalumeau, Nathalie, Luong, Liem Binh, Hamou, Zakaria Ait, Benghanem, Sarah, Blanche, Philippe, Carlier, Nicolas, Chaigne, Benjamin, Gauzit, Remy, Joumaa, Hassan, Jozwiak, Mathieu, Lachétre, Marie, Lafoeste, Hélène, Launay, Odie, Legendre, Paul, Marey, Jonathan, Morbieu, Caroline, Palmieri, Lola-Jade, Szwebel, Tali-Anne, Abdoul, Hendy, Bruneau, Alexandra, Beclin-Clabaux, Audrey, Larrieu, Charly, Montanari, Pierre, Dufour, Eric, Clarke, Ada, Le Bourlout, Catherine, Marin, Nathalie, Menage, Nathalie, Saleh-Mghir, Samira, Cisse, Mamadou Salif, Cheref, Kahina, Guerin, Corinne, Zerbit, Jérémie, Michel, Marc, Gallien, Sébastien, Crickx, Etienne, Le Vavasseur, Benjamin, Kempf, Emmanuelle, Jaffal, Karim, Vindrios, William, Oniszczuk, Julie, Guillaud, Constance, Lim, Pascal, Fois, Elena, Melica, Giovanna, Matignon, Marie, Jalabert, Maud, Lelièvre, Jean-Daniel, Schmitz, David, Bourhis, Marion, Belazouz, Sylia, Languille, Laetitia, Boucle, Caroline, Cita, Nelly, Didier, Agnés, Froura, Fahem, Ledudal, Katia, Sadaoui, Thiziri, Thiemele, Alaki, Le Febvre De Bailly, Delphine, Verlinde, Muriel Carvhalo, Mayaux, Julien, Cacoub, Patrice, Saadoun, David, Vautier, Mathieu, Bugaut, Héléne, Benveniste, Olivier, Allenbach, Yves, Leroux, Gaëlle, Rigolet, Aude, Guillaume-Jugnot, Perrine, Domont, Fanny, Desbois, Anne Claire, Comarmond, Chloé, Champtiaux, Nicolas, Toquet, Segolene, Ghembaza, Amine, Vieira, Matheus, Maalouf, Georgina, Boleto, Goncalo, Ferfar, Yasmina, Corvol, Jean-Christophe, Louapre, C.line, Sambin, Sara, Mariani, Louise-Laure, Karachi, Carine, Tubach, Florence, Estellat, Candice, Gimeno, Linda, Martin, Karine, Bah, Aicha, Keo, Vixra, Ouamri, Sabrine, Messaoudi, Yasmine, Yelles, Nessima, Faye, Pierre, Cavelot, Sebastien, Larcheveque, Cecile, Annonay, Laurence, Benhida, Jaouad, Zahrate-Ghoul, Aida, Hammal, Soumeya, Belilita, Ridha, Charbonnier, Fanny, Aguilar, Claire, Alby-Laurent, Fanny, Burger, Carole, Campos-Vega, Clara, Chavarot, Nathalie, Fournier, Benjamin, Rouzaud, Claire, Vimpére, Damien, Elie, Caroline, Bakouboula, Prissile, Choupeaux, Laure, Granville, Sophie, Issorat, Elodie, Broissand, Christine, Alyanakian, Marie-Alexandra, Geri, Guillaume, Derridj, Nawal, Sguiouar, Naima, Meddah, Hakim, Djadel, Mourad, Chambrin-Lauvray, Héléne, Duclos-vallée, Jean-Charles, Saliba, Faouzi, Sacleux, Sophie-Caroline, Kounis, Ilias, Tamazirt, Sonia, Rudant, Eric, Michot, Jean-Marie, Stoclin, Annabelle, Colomba, Emeline, Pommeret, Fanny, Willekens, Christophe, Da Silva, Rosa, Dejean, Valérie, Mekid, Yasmina, Ben-Mabrouk, Ines, Netzer, Florence, Pradon, Caroline, Drouard, Laurence, Camara-Clayette, Valérie, Morel, Alexandre, Garcia, Gilles, Mohebbi, Abolfazl, Berbour, Férial, Dehais, Mélanie, Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Héléne, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Chan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Marquis, Eric, Benoit, Philippe, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Helene, Mourad, Jean-Jacques, Sacco, Emmanuelle, Renet, Sophie, Ader, F., Yazdanpanah, Y., Mentre, F., Peiffer-Smadja, N., Lescure, F.X., Poissy, J., Bouadma, L., Timsit, J.F., Lina, B., Morfin-Sherpa, F., Bouscambert, M., Gaymard, A., Peytavin, G., Abel, L., Guedj, J., Andrejak, C., Burdet, C., Laouenan, C., Belhadi, D., Dupont, A., Alfaiate, T., Basli, B., Chair, A., Laribi, S., Level, J., Schneider, M., Tellier, M.C., Dechanet, A., Costagliola, D., Terrier, B., Ohana, M., Couffin-Cadiergues, S., Esperou, H., Delmas, C., Saillard, J., Fougerou, C., Moinot, L., Wittkop, L., Cagnot, C., Le Mestre, S., Lebrasseur-Longuet, D., Petrov-Sanchez, V., Diallo, A., Mercier, N., Icard, V., Leveau, B., Tubiana, S., Hamze, B., Gelley, A., Noret, M., D’Ortenzio, E., Puechal, O., Semaille, C., Welte, T., Paiva, J.A., Halanova, M., Kieny, M.P., Balssa, E., Birkle, C., Gibowski, S., Landry, E., Le Goff, A., Moachon, L., Moins, C., Wadouachi, L., Paul, C., Levier, A., Bougon, D., Djossou, F., Epelboin, L., Dellamonica, J., Marquette, C.H., Robert, C., Gibot, S., Senneville, E., Jean-Michel, V., Zerbib, Y., Chirouze, C., Boyer, A., Cazanave, C., Gruson, D., Malvy, D., Andreu, P., Quenot, J.P., Terzi, N., Faure, K., Chabartier, C., Le Moing, V., Klouche, K., Ferry, T., F, Valour, Gaborit, B., Canet, E., Le Turnier, P., Boutoille, D., Bani-Sadr, F., Benezit, F., Revest, M., Cameli, C., Caro, A., Um Tegue, MJ Ngo, Le Tulzo, Y., Laviolle, B., Laine, F., Thiery, G., Meziani, F., Hansmann, Y., Oulehri, W., Tacquard, C., Vardon-Bounes, F., Riu-Poulenc, B., Murris-Espin, M., Bernard, L., Garot, D., Hinschberger, O., Martinot, M., Bruel, C., Pilmis, B., Bouchaud, O., Loubet, P., Roger, C., Monnet, X., Figueiredo, S., Godard, V., Mira, J.P., Lachatre, M., Kerneis, S., Aboab, J., Sayre, N., Crockett, F., Lebeaux, D., Buffet, A., Diehl, J.L., Fayol, A., Hulot, J.S., Livrozet, M., Dessap, A Mekontso, Ficko, C., Stefan, F., Le Pavec, J., Mayaux, J., Ait-Oufella, H., Molina, J.M., Pialoux, G., Fartoukh, M., Textoris, J., Brossard, M., Essat, A., Netzer, E., Riault, Y., Ghislain, M., Beniguel, L., Genin, M., Gouichiche, L., Betard, C., Belkhir, L., Altdorfer, A., Centro, V Fraipont, Braz, S., Ribeiro, JM Ferreira, Alburqueque, R Roncon, Berna, M., Alexandre, M., Lamprecht, B., Egle, A., Greil, R., Joannidis, M., Patterson, Thomas F., Ponce, Philip O., Taylor, Barbara S., Patterson, Jan E., Bowling, Jason E., Javeri, Heta, Kalil, Andre C., Larson, LuAnn, Hewlett, Angela, Mehta, Aneesh K., Rouphael, Nadine G., Saklawi, Youssef, Scanlon, Nicholas, Traenkner, Jessica J., Trible, Ronald P., Jr., Walter, Emmanuel B., Ivey, Noel, Holland, Thomas L., Ruiz-Palacios, Guillermo M., Ponce de León, Alfredo, Rajme, Sandra, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Lee, Helen S., Kline, Susan, Billings, Joanne, Noren, Brooke, Kim, Hyun, Bold, Tyler D., Tapson, Victor, Grein, Jonathan, Sutterwala, Fayyaz, Iovine, Nicole, Beattie, Lars K., Wakeman, Rebecca Murray, Shaw, Matthew, Jain, Mamta K., Mocherla, Satish, Meisner, Jessica, Luque, Amneris, Sweeney, Daniel A., Benson, Constance A., Ali, Farhana, Atmar, Robert L., El Sahly, Hana M., Whitaker, Jennifer, Falsey, Ann R., Branche, Angela R., Rozario, Cheryl, Pineda, Justino Regalado, Martinez-Orozco, José Arturo, Lye, David Chien, Ong, Sean WX., Chia, Po Ying, Young, Barnaby E., Sandkovsky, Uriel, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Cantos, Valeria D., Kelley, Colleen F., Rebolledo Esteinou, Paulina A., Kandiah, Sheetal, Doernberg, Sarah B., Crouch, Pierre-Cedric B., Jang, Hannah, Luetkemeyer, Anne F., Dwyer, Jay, Cohen, Stuart H., Thompson, George R., 3rd, Nguyen, Hien H., Finberg, Robert W., Wang, Jennifer P., Perez-Velazquez, Juan, Wessolossky, Mireya, Jackson, Patrick E.H., Bell, Taison D., West, Miranda J., Taiwo, Babafemi, Krueger, Karen, Perez, Johnny, Pearson, Triniece, Paules, Catharine I., Julian, Kathleen G., Ahmad, Danish, Hajduczok, Alexander G., Arguinchona, Henry, Arguinchona, Christa, Erdmann, Nathaniel, Goepfert, Paul, Ahuja, Neera, Frank, Maria G., Wyles, David, Young, Heather, Oh, Myoung-don, Park, Wan Beom, Kang, Chang Kyung, Marconi, Vincent, Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Kim, Eu Suk, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Tan, Seow Yen, Shafi, Humaira, Chien, Jaime, Fong, Raymond KC., Murray, Daniel D., Lundgren, Jens, Nielsen, Henrik, Jensen, Tomas, Zingman, Barry S., Grossberg, Robert, Riska, Paul F., Yang, Otto O., Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R., Hauser, Naomi, Campbell, James D., Short, William R., Tebas, Pablo, Baron, Jillian T., McLellan, Susan L.F., Blanton, Lucas S., Seashore, Justin B., Creech, C. Buddy, Rice, Todd W., Walker, Shannon, Thomsen, Isaac P., Lopez de Castilla, Diego, Van Winkle, Jason W., Riedo, Francis X., Pada, Surinder Kaur, Wang, Alvin DY., Lin, Li, Harkins, Michelle, Mertz, Gregory, Sosa, Nestor, Ann Chai, Louis Yi, Tambyah, Paul Anantharajah, Tham, Sai Meng, Archuleta, Sophia, Yan, Gabriel, Lindholm, David A., Markelz, Ana Elizabeth, Mende, Katrin, Mularski, Richard, Hohmann, Elizabeth, Torres-Soto, Mariam, Jilg, Nikolaus, Maves, Ryan C., Utz, Gregory C., George, Sarah L., Hoft, Daniel F., Brien, James D., Paredes, Roger, Mateu, Lourdes, Loste, Cora, Kumar, Princy, Thornton, Sarah, Mohanraj, Sharmila, Hynes, Noreen A., Sauer, Lauren M., Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Chambers, Susan E., Novak, Richard M., Wendrow, Andrea, Gupta, Samir K., Lee, Tida, Lalani, Tahaniyat, Holodniy, Mark, Chary, Aarthi, Huprikar, Nikhil, Ganesan, Anuradha, Ohmagari, Norio, Mikami, Ayako, Price, D. Ashley, Duncan, Christopher J.A., Dierberg, Kerry, Neumann, Henry J., Taylor, Stephanie N., Lacour, Alisha, Masri, Najy, Swiatlo, Edwin, Widmer, Kyle, Neaton, James D., Bessesen, Mary, Stephens, David S., Burgess, Timothy H., Uyeki, Timothy M., Walker, Robert, Marks, G. Lynn, Osinusi, Anu, Cao, Huyen, Cardoso, Anabela, de Bono, Stephanie, Schlichting, Douglas E., Chung, Kevin K., Ferreira, Jennifer L., Green, Michelle, Makowski, Mat, Wierzbicki, Michael R., Conrad, Tom M., El-Khorazaty, Jill Ann, Hill, Heather, Bonnett, Tyler, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Beigel, John H., Tomashek, Kay M., Ghazaryan, Varduhi, Beresnev, Tatiana, Nayak, Seema, Dodd, Lori E., Dempsey, Walla, Nomicos, Effie, Lee, Marina, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Voell, Jocelyn D., Davey, Richard, Serrano, Ruth C., Wiley, Zanthia, Phadke, Varun K., Goepfert, Paul A., Gomez, Carlos A., Sofarelli, Theresa A., Certain, Laura, Imlay, Hannah N., Wolfe, Cameron R., Ko, Emily R., Engemann, John J., Felix, Nora Bautista, Wan, Claire R., Elmor, Sammy T., Bristow, Laurel R., Harkins, Michelle S., Iovine, Nicole M., Elie-Turenne, Marie-Carmelle, Tapson, Victor F., Choe, Pyoeng Gyun, Mularski, Richard A., Rhie, Kevin S., Hussein, Rezhan H., Ince, Dilek, Winokur, Patricia L., Takasaki, Jin, Saito, Sho, McConnell, Kimberly, Wyles, David L., Sarcone, Ellen, Grimes, Kevin A., Perez, Katherine, Janak, Charles, Whitaker, Jennifer A., Rebolledo, Paulina A., Gharbin, John, Lambert, Allison A., Zea, Diego F., Bainbridge, Emma, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Ling, Evelyn, Go, Minjoung, Hubbard, Fleesie A., Chakrabarty, Melony, Laguio-Vila, Maryrose, Walsh, Edward E., Guirgis, Faheem, Marconi, Vincent C., Madar, Christian, Borgetti, Scott A., Levine, Corri, Nock, Joy, Candiotti, Keith, Rozman, Julia, Dangond, Fernando, Hyvert, Yann, Seitzinger, Andrea, Cross, Kaitlyn, Pettibone, Stephanie, Nayak, Seema U., Deye, Gregory A., Siempos, Ilias I., Belhadi, Drifa, Veiga, Viviane Cordeiro, Cavalcanti, Alexandre Biasi, Branch-Elliman, Westyn, Papoutsi, Eleni, Gkirgkiris, Konstantinos, Xixi, Nikoleta A., and Kotanidou, Anastasia

Published
2024
Full Text
View/download PDF

5. Immunogenicity and safety of varying dosages of a fifth-wave influenza A/H7N9 inactivated vaccine given with and without AS03 adjuvant in healthy adults

Author

Jackson, Lisa A., Stapleton, Jack T., Walter, Emmanuel B., Chen, Wilbur H., Rouphael, Nadine G., Anderson, Evan J., Neuzil, Kathleen M., Winokur, Patricia L., Smith, Michael J., Schmader, Kenneth E., Swamy, Geeta K., Thompson, Amelia B., Mulligan, Mark J., Rostad, Christina A., Cross, Kaitlyn, Tsong, Rachel, Wegel, Ashley, and Roberts, Paul C.

Published
2024
Full Text
View/download PDF

7. Leveraging antigenic seniority for maternal vaccination to prevent mother-to-child transmission of HIV-1

Author

Nelson, Ashley N., Dennis, Maria, Mangold, Jesse F., Li, Katherine, Saha, Pooja T., Cronin, Kenneth, Cross, Kaitlyn A., Kumar, Amit, Mangan, Riley J., Shaw, George M., Bar, Katharine J., Haynes, Barton, Moody, Anthony M., Munir Alam, S., Pollara, Justin, Hudgens, Michael G., Van Rompay, Koen K. A., De Paris, Kristina, and Permar, Sallie R.

Published
2022
Full Text
View/download PDF

8. Immunization with germ line–targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques.

Author

Nelson, Ashley N., Shen, Xiaoying, Vekatayogi, Sravani, Zhang, Shiyu, Ozorowski, Gabriel, Dennis, Maria, Sewall, Leigh M., Milligan, Emma, Davis, Dominique, Cross, Kaitlyn A., Chen, Yue, van Schooten, Jelle, Eudailey, Joshua, Isaac, John, Memon, Saad, Weinbaum, Carolyn, Gao, Hongmei, Stanfield-Oakley, Sherry, Byrd, Alliyah, and Chutkan, Suni

Subjects
AIDS vaccines, RHESUS monkeys, B cells, HIV-positive persons, BINDING sites
Abstract

Adolescents are a growing population of people living with HIV. The period between weaning and sexual debut presents a low-risk window for HIV acquisition, making early childhood an ideal time for implementing an immunization regimen. Because the elicitation of broadly neutralizing antibodies (bnAbs) is critical for an effective HIV vaccine, our goal was to assess the ability of a bnAb B cell lineage–designed HIV envelope SOSIP (protein stabilized by a disulfide bond between gp120-gp41—named "SOS"—and an isoleucine-to-proline point mutation—named "IP"—at residue 559) to induce precursor CD4 binding site (CD4bs)–targeting bnAbs in early life. Infant rhesus macaques received either a BG505 SOSIP, based on the infant BG505 transmitted/founder virus, or the CD4bs germ line–targeting BG505 SOSIP GT1.1 (n = 5 per group). Although both strategies induced durable, high-magnitude plasma autologous virus neutralization responses, only GT1.1-immunized infants (n = 3 of 5) exhibited VRC01-like CD4bs bnAb precursor development. Thus, a multidose immunization regimen with bnAb lineage–designed SOSIPs shows promise for inducing early B cell responses with the potential to mature into protective HIV bnAbs before sexual debut. Editor's summary: HIV vaccine efforts include developing immunogens that induce broadly neutralizing antibodies (bnAbs). Two studies highlight advances in inducing VRC01 class bnAbs that bind to the conserved CD4 binding site (CD4bs) epitope of the HIV envelope (Env). Caniels et al. used structure-based design to optimize a trimeric HIV Env antigen, called BG505 SOSIP GT1.1 (GT1.1). Adult nonhuman primates (NHPs) immunized with GT1.1 produced antibodies that neutralize fully glycosylated viruses by specifically binding to the CD4bs. Nelson et al. evaluated GT1.1 in infant NHPs compared with a predecessor immunogen, BG505 SOSIP. Both immunogens induced neutralizing antibodies against autologous viruses, but only infants primed with GT1.1 generated VRC01-like CD4bs bnAb precursors upon boosting with BG505 SOSIP. These findings indicate that trimeric germ line–targeting immunogens can elicit neutralizing antibodies toward conserved HIV Env epitopes. (See accompanying Research Article by Caniels et al. and accompanying Focus by Amara.) —Christiana Fogg [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-blind, randomised, placebo-controlled, phase 3 trial

Author

Hewlett, Angela, Taylor, Barbara S, Bowling, Jason E, Serrano, Ruth C, Rouphael, Nadine G, Wiley, Zanthia, Phadke, Varun K, Certain, Laura, Imlay, Hannah N, Engemann, John J, Walter, Emmanuel B, Meisner, Jessica, Rajme, Sandra, Billings, Joanne, Kim, Hyun, Martinez-Orozco, Jose A, Bautista Felix, Nora, Elmor, Sammy T, Bristow, Laurel R, Mertz, Gregory, Sosa, Nestor, Bell, Taison D, West, Miranda J, Elie-Turenne, Marie-Carmelle, Grein, Jonathan, Sutterwala, Fayyaz, Gyun Choe, Pyoeng, Kyung Kang, Chang, El Sahly, Hana M, Rhie, Kevin S, Hussein, Rezhan H, Winokur, Patricia L, Mikami, Ayako, Saito, Sho, Benson, Constance A, McConnell, Kimberly, Berhe, Mezgebe, Dishner, Emma, Frank, Maria G, Sarcone, Ellen, Crouch, Pierre-Cedric B, Jang, Hannah, Jilg, Nikolaus, Perez, Katherine, Janak, Charles, Cantos, Valeria D, Rebolledo, Paulina A, Gharbin, John, Zingman, Barry S, Riska, Paul F, Falsey, Ann R, Walsh, Edward E, Branche, Angela R, Arguinchona, Henry, Arguinchona, Christa, Van Winkle, Jason W, Zea, Diego F, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Dwyer, Jay, Bainbridge, Emma, Hostler, David C, Hostler, Jordanna M, Shahan, Brian T, Hsieh, Lanny, Amin, Alpesh N, Watanabe, Miki, Short, William R, Tebas, Pablo, Baron, Jillian T, Ahuja, Neera, Ling, Evelyn, Go, Minjoung, Yang, Otto O, Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R, Hubbard, Fleesie A, Campbell, James D, Cohen, Stuart H, Thompson, George R, 3rd, Chakrabarty, Melony, Taylor, Stephanie N, Masri, Najy, Lacour, Alisha, Lee, Tida, Lalani, Tahaniyat, Lindholm, David A, Markelz, Ana Elizabeth, Mende, Katrin, Colombo, Christopher J, Schofield, Christina, Colombo, Rhonda E, Guirgis, Faheem, Holodniy, Mark, Chary, Aarthi, Bessesen, Mary, Hynes, Noreen A, Sauer, Lauren M, Marconi, Vincent C, Moanna, Abeer, Harrison, Telisha, Lye, David C, Ong, Sean W X, Ying Chia, Po, Huprikar, Nikhil, Ganesan, Anuradha, Madar, Christian, Novak, Richard M, Wendrow, Andrea, Borgetti, Scott A, George, Sarah L, Hoft, Daniel F, Brien, James D, McLellan, Susan L F, Levine, Corri, Nock, Joy, Yen Tan, Seow, Shafi, Humaira, Chien, Jaime M F, Candiotti, Keith, Finberg, Robert W, Wang, Jennifer P, Wessolossky, Mireya, Utz, Gregory C, Chambers, Susan E, Stephens, David S, Burgess, Timothy H, Rozman, Julia, Hyvert, Yann, Seitzinger, Andrea, Osinusi, Anu, Cao, Huyen, Chung, Kevin K, Conrad, Tom M, Cross, Kaitlyn, El-Khorazaty, Jill A, Hill, Heather, Pettibone, Stephanie, Wierzbicki, Michael R, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Deye, Gregory A, Nomicos, Effie, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Davey, Richard, Yokum, Tammy, Arega, Janice, Florese, Ruth, Kalil, Andre C, Mehta, Aneesh K, Patterson, Thomas F, Erdmann, Nathaniel, Gomez, Carlos A, Jain, Mamta K, Wolfe, Cameron R, Ruiz-Palacios, Guillermo M, Kline, Susan, Regalado Pineda, Justino, Luetkemeyer, Anne F, Harkins, Michelle S, Jackson, Patrick E H, Iovine, Nicole M, Tapson, Victor F, Oh, Myoung-don, Whitaker, Jennifer A, Mularski, Richard A, Paules, Catharine I, Ince, Dilek, Takasaki, Jin, Sweeney, Daniel A, Sandkovsky, Uriel, Wyles, David L, Hohmann, Elizabeth, Grimes, Kevin A, Grossberg, Robert, Laguio-Vila, Maryrose, Lambert, Allison A, Lopez de Castilla, Diego, Kim, EuSuk, Larson, LuAnn, Wan, Claire R, Traenkner, Jessica J, Ponce, Philip O, Patterson, Jan E, Goepfert, Paul A, Sofarelli, Theresa A, Mocherla, Satish, Ko, Emily R, Ponce de Leon, Alfredo, Doernberg, Sarah B, Atmar, Robert L, Maves, Ryan C, Dangond, Fernando, Ferreira, Jennifer, Green, Michelle, Makowski, Mat, Bonnett, Tyler, Beresnev, Tatiana, Ghazaryan, Varduhi, Dempsey, Walla, Nayak, Seema U, Dodd, Lori, Tomashek, Kay M, and Beigel, John H

Published
2021
Full Text
View/download PDF

10. A Phase 2 Clinical Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of Different Prime-Boost Vaccination Schedules of 2013 and 2017 A(H7N9) Inactivated Influenza Virus Vaccines Administered with and without AS03 Adjuvant in Healthy US Adults

Author

Rostad, Christina A, primary, Atmar, Robert L, additional, Walter, Emmanuel B, additional, Frey, Sharon, additional, Meier, Jeffery L, additional, Sherman, Amy C, additional, Lai, Lilin, additional, Tsong, Rachel, additional, Kao, Carol M, additional, Raabe, Vanessa, additional, El Sahly, Hana M, additional, Keitel, Wendy A, additional, Whitaker, Jennifer A, additional, Smith, Michael J, additional, Schmader, Kenneth E, additional, Swamy, Geeta K, additional, Abate, Getahun, additional, Winokur, Patricia, additional, Buchanan, Wendy, additional, Cross, Kaitlyn, additional, Wegel, Ashley, additional, Xu, Yongxian, additional, Yildirim, Inci, additional, Kamidani, Satoshi, additional, Rouphael, Nadine, additional, Roberts, Paul C, additional, Mulligan, Mark J, additional, and Anderson, Evan J, additional

Published
2024
Full Text
View/download PDF

11. Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

Author

Nelson, Ashley N, primary, Shen, Xiaoying, additional, Venkatayogi, Sravani, additional, Zhang, Shiyu, additional, Ozorowski, Gabriel, additional, Dennis, Maria, additional, Sewall, Leigh M, additional, Milligan, Emma, additional, Davis, Dominique, additional, Cross, Kaitlyn, additional, Chen, Yue, additional, van Schooten, Jelle, additional, Eudaily, Joshua, additional, Isaac, John, additional, Memon, Saad, additional, Weinbaum, Carolyn, additional, Stanfield-Oakley, Sherry, additional, Byrd, Alliyah, additional, Chutkan, Suni, additional, Berendam, Stella, additional, Cronin, Kenneth, additional, Yasmeen, Anila, additional, Alam, S.Munir, additional, LeBranche, Celia, additional, Rogers, Kenneth, additional, Shirreff, Lisa, additional, Cupo, Albert, additional, Derking, Ronlad, additional, Villinger, Francois, additional, Klasse, Per Johan, additional, Ferrari, Guido, additional, Williams, Wilton B, additional, Hudgens, Michael G, additional, Ward, Andrew B, additional, Montefiori, David C, additional, VanRompay, Koen, additional, Wiehe, Kevin, additional, Moore, John P, additional, Sanders, Rogier W, additional, De Paris, Kristina, additional, and Permar, Sallie R, additional

Published
2023
Full Text
View/download PDF

12. Visual findings in children exposed to Zika in utero in Nicaragua

Author

Martinez, Evelin, primary, Max, Ryan, additional, Bucardo, Filemón, additional, Stringer, Elizabeth M., additional, Becker-Dreps, Sylvia, additional, Toval-Ruíz, Christian, additional, Chavarria, Meylin, additional, Meléndez-Balmaceda, María J., additional, Nuñez, Carlos, additional, Collins, Matthew H., additional, Boivin, Michael, additional, Ortiz-Pujols, Shiara, additional, Zepeda, Omar, additional, Cross, Kaitlyn, additional, Gower, Emily W., additional, Bowman, Natalie M., additional, and Grace, Sara F., additional

Published
2023
Full Text
View/download PDF

13. Baricitinib treatment of COVID-19 is associated with a reduction of secondary infections

Author

Sweeney, Daniel A, primary, Tuyishimire, Bonifride, additional, Ahuja, Neera, additional, Beigel, John H, additional, Beresnev, Tatiana, additional, Cantos, Valeria D, additional, Castro, Jose G, additional, Cohen, Stuart H, additional, Cross, Kaitlyn, additional, Dodd, Lori E, additional, Erdmann, Nathan, additional, Fung, Monica, additional, Ghazaryan, Varduhi, additional, George, Sarah L, additional, Grimes, Kevin A, additional, Hynes, Noreen A, additional, Julian, Kathleen G, additional, Kandiah, Sheetal, additional, Kim, Hannah Jang, additional, Levine, Corri B, additional, Lindholm, David A, additional, Lye, David C, additional, Maves, Ryan C, additional, Oh, Myoung-don, additional, Paules, Catharine, additional, Rapaka, Rekha R, additional, Short, Willam R, additional, Tomashek, Kay M, additional, Wolfe, Cameron R, additional, and Kalil, Andre C, additional

Published
2023
Full Text
View/download PDF

14. Antibody Immunity to Zika Virus among Young Children in a Flavivirus-Endemic Area in Nicaragua

Author

Zepeda, Omar, primary, Espinoza, Daniel O., additional, Martinez, Evelin, additional, Cross, Kaitlyn A., additional, Becker-Dreps, Sylvia, additional, de Silva, Aravinda M., additional, Bowman, Natalie M., additional, Premkumar, Lakshmanane, additional, Stringer, Elizabeth M., additional, Bucardo, Filemón, additional, and Collins, Matthew H., additional

Published
2023
Full Text
View/download PDF

15. Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later

Author

Milligan, Emma C., primary, Olstad, Katherine, additional, Williams, Caitlin A., additional, Mallory, Michael, additional, Cano, Patricio, additional, Cross, Kaitlyn A., additional, Munt, Jennifer E., additional, Garrido, Carolina, additional, Lindesmith, Lisa, additional, Watanabe, Jennifer, additional, Usachenko, Jodie L., additional, Hopkins, Lincoln, additional, Immareddy, Ramya, additional, Shaan Lakshmanappa, Yashavanth, additional, Elizaldi, Sonny R., additional, Roh, Jamin W., additional, Sammak, Rebecca L., additional, Pollard, Rachel E., additional, Yee, JoAnn L., additional, Herbek, Savannah, additional, Scobey, Trevor, additional, Miehlke, Dieter, additional, Fouda, Genevieve, additional, Ferrari, Guido, additional, Gao, Hongmei, additional, Shen, Xiaoying, additional, Kozlowski, Pamela A., additional, Montefiori, David, additional, Hudgens, Michael G., additional, Edwards, Darin K., additional, Carfi, Andrea, additional, Corbett, Kizzmekia S., additional, Graham, Barney S., additional, Fox, Christopher B., additional, Tomai, Mark, additional, Iyer, Smita S., additional, Baric, Ralph, additional, Reader, Rachel, additional, Dittmer, Dirk P., additional, Van Rompay, Koen K.A., additional, Permar, Sallie R., additional, and De Paris, Kristina, additional

Published
2023
Full Text
View/download PDF

16. Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later.

Author

Milligan, Emma C, Milligan, Emma C, Olstad, Katherine, Williams, Caitlin A, Mallory, Michael, Cano, Patricio, Cross, Kaitlyn A, Munt, Jennifer E, Garrido, Carolina, Lindesmith, Lisa, Watanabe, Jennifer, Usachenko, Jodie L, Hopkins, Lincoln, Immareddy, Ramya, Shaan Lakshmanappa, Yashavanth, Elizaldi, Sonny R, Roh, Jamin W, Sammak, Rebecca L, Pollard, Rachel E, Yee, JoAnn L, Herbek, Savannah, Scobey, Trevor, Miehlke, Dieter, Fouda, Genevieve, Ferrari, Guido, Gao, Hongmei, Shen, Xiaoying, Kozlowski, Pamela A, Montefiori, David, Hudgens, Michael G, Edwards, Darin K, Carfi, Andrea, Corbett, Kizzmekia S, Graham, Barney S, Fox, Christopher B, Tomai, Mark, Iyer, Smita S, Baric, Ralph, Reader, Rachel, Dittmer, Dirk P, Van Rompay, Koen KA, Permar, Sallie R, De Paris, Kristina, Milligan, Emma C, Milligan, Emma C, Olstad, Katherine, Williams, Caitlin A, Mallory, Michael, Cano, Patricio, Cross, Kaitlyn A, Munt, Jennifer E, Garrido, Carolina, Lindesmith, Lisa, Watanabe, Jennifer, Usachenko, Jodie L, Hopkins, Lincoln, Immareddy, Ramya, Shaan Lakshmanappa, Yashavanth, Elizaldi, Sonny R, Roh, Jamin W, Sammak, Rebecca L, Pollard, Rachel E, Yee, JoAnn L, Herbek, Savannah, Scobey, Trevor, Miehlke, Dieter, Fouda, Genevieve, Ferrari, Guido, Gao, Hongmei, Shen, Xiaoying, Kozlowski, Pamela A, Montefiori, David, Hudgens, Michael G, Edwards, Darin K, Carfi, Andrea, Corbett, Kizzmekia S, Graham, Barney S, Fox, Christopher B, Tomai, Mark, Iyer, Smita S, Baric, Ralph, Reader, Rachel, Dittmer, Dirk P, Van Rompay, Koen KA, Permar, Sallie R, and De Paris, Kristina

Abstract

The U.S. Food and Drug Administration only gave emergency use authorization of the BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines for infants 6 months and older in June 2022. Yet questions regarding the durability of vaccine efficacy, especially against emerging variants, in this age group remain. We demonstrated previously that a two-dose regimen of stabilized prefusion Washington SARS-CoV-2 S-2P spike (S) protein encoded by mRNA encapsulated in lipid nanoparticles (mRNA-LNP) or purified S-2P mixed with 3M-052, a synthetic Toll-like receptor (TLR) 7/8 agonist, in a squalene emulsion (Protein+3M-052-SE) was safe and immunogenic in infant rhesus macaques. Here, we demonstrate that broadly neutralizing and spike-binding antibodies against variants of concern (VOCs), as well as T cell responses, persisted for 12 months. At 1 year, corresponding to human toddler age, we challenged vaccinated rhesus macaques and age-matched nonvaccinated controls intranasally and intratracheally with a high dose of heterologous SARS-CoV-2 B.1.617.2 (Delta). Seven of eight control rhesus macaques exhibited severe interstitial pneumonia and high virus replication in the upper and lower respiratory tract. In contrast, vaccinated rhesus macaques had faster viral clearance with mild to no pneumonia. Neutralizing and binding antibody responses to the B.1.617.2 variant at the day of challenge correlated with lung pathology and reduced virus replication. Overall, the Protein+3M-052-SE vaccine provided superior protection to the mRNA-LNP vaccine, emphasizing opportunities for optimization of current vaccine platforms. The observed efficacy of both vaccines 1 year after vaccination supports the implementation of an early-life SARS-CoV-2 vaccine.

Published
2023

17. An Oil-in-Water adjuvant significantly increased influenza A/H7N9 split virus Vaccine-Induced circulating follicular helper T (cTFH) cells and antibody responses

Author

Lai, Lilin, primary, Rouphael, Nadine, additional, Xu, Yongxian, additional, Kabbani, Sarah, additional, Beck, Allison, additional, Sherman, Amy, additional, Anderson, Evan J., additional, Bellamy, Abbie, additional, Weiss, Julia, additional, Cross, Kaitlyn, additional, and Mulligan, Mark J, additional

Published
2022
Full Text
View/download PDF

18. Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge one year later

Author

Williams, Caitlin A., De Paris, Kristina, Watanabe, Jennifer, Corbett, Kizzmekia S., Lakshmanappa, Yashavanth Shaan, Herbek, Savannah, Roh, Jamin W., Sammak, Rebecca L., Pollard, Rachel E., Olstad, Katherine, Scobey, Trevor, Fouda, Genevieve, Yee, JoAnn L., Elizaldi, Sonny R., Dittmer, Dirk P., Hopkins, Lincoln, Cano, Patricio, Cross, Kaitlyn A., Carfi, Andrea, Graham, Barney S., Van Rompay, Koen K.A., Permar, Sallie R., Reader, Rachel, Tomai, Mark, Lindesmith, Lisa, Mallory, Michael, Miehlke, Dieter, Fox, Christopher B., Iyer, Smita S., Usachenko, Jodie L., Baric, Ralph, Munt, Jennifer E., Edwards, Darin K., Kozlowski, Pamela A., Ferrari, Guido, Immareddy, Ramya, Milligan, Emma C., Shen, Xiaoying, Hudgens, Michael G., Montefiori, David, Gao, Hongmei, and Garrido, Carolina

Abstract

The U.S. Food and Drug Administration only gave emergency-use-authorization of the BNT162b2 and the mRNA-1273 SARS-CoV-2 vaccines for infants 6 months and older in June 2022. Yet, questions regarding the durability of vaccine efficacy, especially against emerging variants, in this age group remain. We demonstrated previously that a two-dose regimen of stabilized prefusion Washington SARS-CoV-2 S-2P spike (S) protein encoded by mRNA encapsulated in lipid nanoparticles (mRNA-LNP) or purified S-2P mixed with 3 M-052, a synthetic toll-like receptor (TLR) 7/8 agonist, in a squalene emulsion (Protein+3 M-052-SE) was safe and immunogenic in infant rhesus macaques. Here, we demonstrate that broadly neutralizing and spike-binding antibodies against variants of concern (VOC), as well as T cell responses, persisted for 12 months. At one year, corresponding to human toddler age, we challenged vaccinated rhesus macaques and age-matched non-vaccinated controls intranasally and intratracheally with a high-dose of heterologous SARS-CoV-2 B.1.617.2 (Delta). Seven of eight control rhesus macaques exhibited severe interstitial pneumonia and high virus replication in the upper and lower respiratory tract. In contrast, vaccinated rhesus macaques had faster viral clearance with mild to no pneumonia. Neutralizing and binding antibody responses to the B.1.617.2 variant at the day of challenge correlated with lung pathology and reduced virus replication. Overall, the Protein+3 M-052-SE vaccine provided superior protection to the mRNA-LNP vaccine, emphasizing opportunities for optimization of current vaccine platforms. Notably, the observed efficacy of both vaccines one year after vaccination supports the implementation of an early life SARS-CoV-2 vaccine.

Published
2022

19. Early post-vaccination gene signatures correlate with the magnitude and function of vaccine-induced HIV envelope-specific plasma antibodies in infant rhesus macaques

Author

Kandiyil, Vidya Vijayan Karuvan, primary, Curtis, Alan D, additional, Cross, Kaitlyn, additional, Van Rompay, Koen K A, additional, Pollara, Justin, additional, Fox, Christopher, additional, Tomai, Mark, additional, Hanke, Tomas, additional, Fouda, Genevieve, additional, Hudgens, Michael, additional, Permar, Sallie R, additional, and De Paris, Kristina, additional

Published
2022
Full Text
View/download PDF

20. Early Post-Vaccination Gene Signatures Correlate With the Magnitude and Function of Vaccine-Induced HIV Envelope-Specific Plasma Antibodies in Infant Rhesus Macaques

Author

Vijayan, K. K. Vidya, primary, Cross, Kaitlyn A., additional, Curtis, Alan D., additional, Van Rompay, Koen K. A., additional, Pollara, Justin, additional, Fox, Christopher B., additional, Tomai, Mark, additional, Hanke, Tomáš, additional, Fouda, Genevieve, additional, Hudgens, Michael G., additional, Permar, Sallie R., additional, and De Paris, Kristina, additional

Published
2022
Full Text
View/download PDF

21. Vaccine-Induced, High-Magnitude HIV Env-Specific Antibodies with Fc-Mediated Effector Functions Are Insufficient to Protect Infant Rhesus Macaques against Oral SHIV Infection

Author

Curtis, Alan D., primary, Saha, Pooja T., additional, Dennis, Maria, additional, Berendam, Stella J., additional, Ramasubramanian, Pratamesh, additional, Cross, Kaitlyn A., additional, Alam, S. Munir, additional, Ferrari, Guido, additional, Kozlowski, Pamela A., additional, Fouda, Genevieve G., additional, Hudgens, Michael G., additional, Van Rompay, Koen K. A., additional, Pollara, Justin, additional, Permar, Sallie R., additional, and De Paris, Kristina, additional

Published
2022
Full Text
View/download PDF

22. Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-blind, randomised, placebo-controlled, phase 3 trial

Author

Kalil, Andre C, primary, Mehta, Aneesh K, additional, Patterson, Thomas F, additional, Erdmann, Nathaniel, additional, Gomez, Carlos A, additional, Jain, Mamta K, additional, Wolfe, Cameron R, additional, Ruiz-Palacios, Guillermo M, additional, Kline, Susan, additional, Regalado Pineda, Justino, additional, Luetkemeyer, Anne F, additional, Harkins, Michelle S, additional, Jackson, Patrick E H, additional, Iovine, Nicole M, additional, Tapson, Victor F, additional, Oh, Myoung-don, additional, Whitaker, Jennifer A, additional, Mularski, Richard A, additional, Paules, Catharine I, additional, Ince, Dilek, additional, Takasaki, Jin, additional, Sweeney, Daniel A, additional, Sandkovsky, Uriel, additional, Wyles, David L, additional, Hohmann, Elizabeth, additional, Grimes, Kevin A, additional, Grossberg, Robert, additional, Laguio-Vila, Maryrose, additional, Lambert, Allison A, additional, Lopez de Castilla, Diego, additional, Kim, EuSuk, additional, Larson, LuAnn, additional, Wan, Claire R, additional, Traenkner, Jessica J, additional, Ponce, Philip O, additional, Patterson, Jan E, additional, Goepfert, Paul A, additional, Sofarelli, Theresa A, additional, Mocherla, Satish, additional, Ko, Emily R, additional, Ponce de Leon, Alfredo, additional, Doernberg, Sarah B, additional, Atmar, Robert L, additional, Maves, Ryan C, additional, Dangond, Fernando, additional, Ferreira, Jennifer, additional, Green, Michelle, additional, Makowski, Mat, additional, Bonnett, Tyler, additional, Beresnev, Tatiana, additional, Ghazaryan, Varduhi, additional, Dempsey, Walla, additional, Nayak, Seema U, additional, Dodd, Lori, additional, Tomashek, Kay M, additional, Beigel, John H, additional, Hewlett, Angela, additional, Taylor, Barbara S, additional, Bowling, Jason E, additional, Serrano, Ruth C, additional, Rouphael, Nadine G, additional, Wiley, Zanthia, additional, Phadke, Varun K, additional, Certain, Laura, additional, Imlay, Hannah N, additional, Engemann, John J, additional, Walter, Emmanuel B, additional, Meisner, Jessica, additional, Rajme, Sandra, additional, Billings, Joanne, additional, Kim, Hyun, additional, Martinez-Orozco, Jose A, additional, Bautista Felix, Nora, additional, Elmor, Sammy T, additional, Bristow, Laurel R, additional, Mertz, Gregory, additional, Sosa, Nestor, additional, Bell, Taison D, additional, West, Miranda J, additional, Elie-Turenne, Marie-Carmelle, additional, Grein, Jonathan, additional, Sutterwala, Fayyaz, additional, Gyun Choe, Pyoeng, additional, Kyung Kang, Chang, additional, El Sahly, Hana M, additional, Rhie, Kevin S, additional, Hussein, Rezhan H, additional, Winokur, Patricia L, additional, Mikami, Ayako, additional, Saito, Sho, additional, Benson, Constance A, additional, McConnell, Kimberly, additional, Berhe, Mezgebe, additional, Dishner, Emma, additional, Frank, Maria G, additional, Sarcone, Ellen, additional, Crouch, Pierre-Cedric B, additional, Jang, Hannah, additional, Jilg, Nikolaus, additional, Perez, Katherine, additional, Janak, Charles, additional, Cantos, Valeria D, additional, Rebolledo, Paulina A, additional, Gharbin, John, additional, Zingman, Barry S, additional, Riska, Paul F, additional, Falsey, Ann R, additional, Walsh, Edward E, additional, Branche, Angela R, additional, Arguinchona, Henry, additional, Arguinchona, Christa, additional, Van Winkle, Jason W, additional, Zea, Diego F, additional, Jung, Jongtak, additional, Song, Kyoung-Ho, additional, Kim, Hong Bin, additional, Dwyer, Jay, additional, Bainbridge, Emma, additional, Hostler, David C, additional, Hostler, Jordanna M, additional, Shahan, Brian T, additional, Hsieh, Lanny, additional, Amin, Alpesh N, additional, Watanabe, Miki, additional, Short, William R, additional, Tebas, Pablo, additional, Baron, Jillian T, additional, Ahuja, Neera, additional, Ling, Evelyn, additional, Go, Minjoung, additional, Yang, Otto O, additional, Ahn, Jenny, additional, Arias, Rubi, additional, Rapaka, Rekha R, additional, Hubbard, Fleesie A, additional, Campbell, James D, additional, Cohen, Stuart H, additional, Thompson, George R, additional, Chakrabarty, Melony, additional, Taylor, Stephanie N, additional, Masri, Najy, additional, Lacour, Alisha, additional, Lee, Tida, additional, Lalani, Tahaniyat, additional, Lindholm, David A, additional, Markelz, Ana Elizabeth, additional, Mende, Katrin, additional, Colombo, Christopher J, additional, Schofield, Christina, additional, Colombo, Rhonda E, additional, Guirgis, Faheem, additional, Holodniy, Mark, additional, Chary, Aarthi, additional, Bessesen, Mary, additional, Hynes, Noreen A, additional, Sauer, Lauren M, additional, Marconi, Vincent C, additional, Moanna, Abeer, additional, Harrison, Telisha, additional, Lye, David C, additional, Ong, Sean W X, additional, Ying Chia, Po, additional, Huprikar, Nikhil, additional, Ganesan, Anuradha, additional, Madar, Christian, additional, Novak, Richard M, additional, Wendrow, Andrea, additional, Borgetti, Scott A, additional, George, Sarah L, additional, Hoft, Daniel F, additional, Brien, James D, additional, McLellan, Susan L F, additional, Levine, Corri, additional, Nock, Joy, additional, Yen Tan, Seow, additional, Shafi, Humaira, additional, Chien, Jaime M F, additional, Candiotti, Keith, additional, Finberg, Robert W, additional, Wang, Jennifer P, additional, Wessolossky, Mireya, additional, Utz, Gregory C, additional, Chambers, Susan E, additional, Stephens, David S, additional, Burgess, Timothy H, additional, Rozman, Julia, additional, Hyvert, Yann, additional, Seitzinger, Andrea, additional, Osinusi, Anu, additional, Cao, Huyen, additional, Chung, Kevin K, additional, Conrad, Tom M, additional, Cross, Kaitlyn, additional, El-Khorazaty, Jill A, additional, Hill, Heather, additional, Pettibone, Stephanie, additional, Wierzbicki, Michael R, additional, Gettinger, Nikki, additional, Engel, Theresa, additional, Lewis, Teri, additional, Wang, Jing, additional, Deye, Gregory A, additional, Nomicos, Effie, additional, Pikaart-Tautges, Rhonda, additional, Elsafy, Mohamed, additional, Jurao, Robert, additional, Koo, Hyung, additional, Proschan, Michael, additional, Davey, Richard, additional, Yokum, Tammy, additional, Arega, Janice, additional, and Florese, Ruth, additional

Published
2021
Full Text
View/download PDF

23. Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Author

Widge, Alicia T., primary, Rouphael, Nadine G., additional, Jackson, Lisa A., additional, Anderson, Evan J., additional, Roberts, Paul C., additional, Makhene, Mamodikoe, additional, Chappell, James D., additional, Denison, Mark R., additional, Stevens, Laura J., additional, Pruijssers, Andrea J., additional, McDermott, Adrian B., additional, Flach, Britta, additional, Lin, Bob C., additional, Doria-Rose, Nicole A., additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Neuzil, Kathleen M., additional, Bennett, Hamilton, additional, Leav, Brett, additional, Makowski, Mat, additional, Albert, Jim, additional, Cross, Kaitlyn, additional, Edara, Venkata-Viswanadh, additional, Floyd, Katharine, additional, Suthar, Mehul S., additional, Buchanan, Wendy, additional, Luke, Catherine J., additional, Ledgerwood, Julie E., additional, Mascola, John R., additional, Graham, Barney S., additional, and Beigel, John H., additional

Published
2021
Full Text
View/download PDF

24. Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

Author

Anderson, Evan J., primary, Rouphael, Nadine G., additional, Widge, Alicia T., additional, Jackson, Lisa A., additional, Roberts, Paul C., additional, Makhene, Mamodikoe, additional, Chappell, James D., additional, Denison, Mark R., additional, Stevens, Laura J., additional, Pruijssers, Andrea J., additional, McDermott, Adrian B., additional, Flach, Britta, additional, Lin, Bob C., additional, Doria-Rose, Nicole A., additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Corbett, Kizzmekia S., additional, Swanson, Phillip A., additional, Padilla, Marcelino, additional, Neuzil, Kathy M., additional, Bennett, Hamilton, additional, Leav, Brett, additional, Makowski, Mat, additional, Albert, Jim, additional, Cross, Kaitlyn, additional, Edara, Venkata Viswanadh, additional, Floyd, Katharine, additional, Suthar, Mehul S., additional, Martinez, David R., additional, Baric, Ralph, additional, Buchanan, Wendy, additional, Luke, Catherine J., additional, Phadke, Varun K., additional, Rostad, Christina A., additional, Ledgerwood, Julie E., additional, Graham, Barney S., additional, and Beigel, John H., additional

Published
2020
Full Text
View/download PDF

25. An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

Author

Jackson, Lisa A., primary, Anderson, Evan J., additional, Rouphael, Nadine G., additional, Roberts, Paul C., additional, Makhene, Mamodikoe, additional, Coler, Rhea N., additional, McCullough, Michele P., additional, Chappell, James D., additional, Denison, Mark R., additional, Stevens, Laura J., additional, Pruijssers, Andrea J., additional, McDermott, Adrian, additional, Flach, Britta, additional, Doria-Rose, Nicole A., additional, Corbett, Kizzmekia S., additional, Morabito, Kaitlyn M., additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Swanson, Phillip A., additional, Padilla, Marcelino, additional, Mascola, John R., additional, Neuzil, Kathleen M., additional, Bennett, Hamilton, additional, Sun, Wellington, additional, Peters, Etza, additional, Makowski, Mat, additional, Albert, Jim, additional, Cross, Kaitlyn, additional, Buchanan, Wendy, additional, Pikaart-Tautges, Rhonda, additional, Ledgerwood, Julie E., additional, Graham, Barney S., additional, and Beigel, John H., additional

Published
2020
Full Text
View/download PDF

27. Baseline Levels of Influenza-Specific B Cells and T Cell Responses Modulate Human Immune Responses to Swine Variant Influenza A/H3N2 Vaccine

Author

Lai, Lilin, primary, Rouphael, Nadine, additional, Xu, Yongxian, additional, Sherman, Amy C., additional, Edupuganti, Srilatha, additional, Anderson, Evan J., additional, Lankford-Turner, Pamela, additional, Wang, Dongli, additional, Keitel, Wendy, additional, McNeal, Monica M., additional, Cross, Kaitlyn, additional, Hill, Heather, additional, Bellamy, Abbie R., additional, and Mulligan, Mark J., additional

Published
2020
Full Text
View/download PDF

29. The Genetic Basis of a Rare Flower Color Polymorphism in Mimulus lewisii Provides Insight into the Repeatability of Evolution.

Author

Wu, Carrie A., Streisfeld, Matthew A., Nutter, Laura I., and Cross, Kaitlyn A.

Subjects
FLOWERS, COLOR of plants, MONKEYFLOWERS, PLANT evolution, GENETIC polymorphisms, BIOLOGICAL evolution, PLANT mutation, GENE expression in plants
Abstract

A long-standing question in evolutionary biology asks whether the genetic changes contributing to phenotypic evolution are predictable. Here, we identify a genetic change associated with segregating variation in flower color within a population of Mimulus lewisii. To determine whether these types of changes are predictable, we combined this information with data from other species to investigate whether the spectrum of mutations affecting flower color transitions differs based on the evolutionary time-scale since divergence. We used classic genetic techniques, along with gene expression and population genetic approaches, to identify the putative, loss-of-function mutation that generates rare, white flowers instead of the common, pink color in M. lewisii. We found that a frameshift mutation in an anthocyanin pathway gene is responsible for the white-flowered polymorphism found in this population of M. lewisii. Comparison of our results with data from other species reveals a broader spectrum of flower color mutations segregating within populations relative to those that fix between populations. These results suggest that the genetic basis of fixed differences in flower color may be predictable, but that for segregating variation is not. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

30. Charting the impact of maternal antibodies and repeat exposures on sapovirus immunity in early childhood from a Nicaraguan birth cohort.

Author

Bucardo F, Mallory ML, González F, Reyes Y, Vielot NA, Yount BL, Sims AC, Nguyen C, Cross K, Toval-Ruíz C, Gutiérrez L, Vinjé J, Baric RS, Lindesmith LC, and Becker-Dreps S

Abstract

Background: Sapovirus is an important cause of acute gastroenteritis in childhood. While vaccines against sapovirus may reduce gastroenteritis burden, a major challenge to their development is a lack of information about natural immunity., Methods: We measured sapovirus-specific IgG in serum collected, between 2017 and 2020, of mothers soon after delivery and at 6 time points in Nicaraguan children until 3 years of age (n=112 dyads) using virus-like particles representing three sapovirus genotypes (GI.1, GI.2, GV.1)., Results: Sixteen (14.3%) of the 112 children experienced at least one sapovirus gastroenteritis episode, of which GI.1 was the most common genotype. Seroconversion to GI.1 and GI.2 was most common between 5 and 12 months of age, while seroconversion to GV.1 peaked at 18 to 24 months of age. All children who experienced sapovirus GI.1 gastroenteritis seroconverted and developed genotype-specific IgG. The impact of sapovirus exposure on population immunity was determined using antigenic cartography: newborns share their mothers' broadly binding IgG responses, which declined at 5 months of age and then increased as infants experienced natural sapovirus infections., Conclusion: By tracking humoral immunity to sapovirus over the first 3 years of life, this study provides important insights for the design and timing of future pediatric sapovirus vaccines., (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
Full Text
View/download PDF

31. Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

Author

Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam SM, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, and Permar SR

Abstract

A vaccine that can achieve protective immunity prior to sexual debut is critical to prevent the estimated 410,000 new HIV infections that occur yearly in adolescents. As children living with HIV can make broadly neutralizing antibody (bnAb) responses in plasma at a faster rate than adults, early childhood is an opportune window for implementation of a multi-dose HIV immunization strategy to elicit protective immunity prior to adolescence. Therefore, the goal of our study was to assess the ability of a B cell lineage-designed HIV envelope SOSIP to induce bnAbs in early life. Infant rhesus macaques (RMs) received either BG505 SOSIP or the germline-targeting BG505 GT1.1 SOSIP (n=5/group) with the 3M-052-SE adjuvant at 0, 6, and 12 weeks of age. All infant RMs were then boosted with the BG505 SOSIP at weeks 26, 52 and 78, mimicking a pediatric immunization schedule of multiple vaccine boosts within the first two years of life. Both immunization strategies induced durable, high magnitude binding antibodies and plasma autologous virus neutralization that primarily targeted the CD4-binding site (CD4bs) or C3/465 epitope. Notably, three BG505 GT1.1-immunized infants exhibited a plasma HIV neutralization signature reflective of VRC01-like CD4bs bnAb precursor development and heterologous virus neutralization. Finally, infant RMs developed precursor bnAb responses at a similar frequency to that of adult RMs receiving a similar immunization strategy. Thus, a multi-dose immunization regimen with bnAb lineage designed SOSIPs is a promising strategy for inducing protective HIV bnAb responses in childhood prior to adolescence when sexual HIV exposure risk begins., Competing Interests: Competing interests: RWS, JPM and ABW are co-inventors on a patent related to BG505 SOSIP trimers, while RWS is also an inventor on a patent related to BG505 GT1.1. SRP serves as a consultant to Moderna, Merck, Pfizer, Dynavax, Hoopika, and GSK vaccine programs for CMV, and leads sponsored research programs with Moderna, Dynavax, and Merck on CMV vaccines.

Published
2023
Full Text
View/download PDF

32. An Oil-in-Water adjuvant significantly increased influenza A/H7N9 split virus Vaccine-Induced circulating follicular helper T (cT FH ) cells and antibody responses.

Author

Lai L, Rouphael N, Xu Y, Kabbani S, Beck A, Sherman A, Anderson EJ, Bellamy A, Weiss J, Cross K, and Mulligan MJ

Subjects
Humans, Antibody Formation, Antibodies, Viral, Squalene, Polysorbates, Adjuvants, Immunologic, Hemagglutination Inhibition Tests, Antibodies, Neutralizing, Water, Influenza A Virus, H7N9 Subtype, Influenza, Human prevention & control, Influenza Vaccines
Abstract

Background: Unadjuvanted A/H7N9 vaccines are poorly immunogenic. The immune response is improved with the addition of MF59, an oil-in-water adjuvant. However, the cellular immunologic responses of MF59-adjuvanted A/H7N9 vaccine are not fully understood., Methods: 37 participants were vaccinated with 2 doses of 2013 influenza A/H7N9 vaccine (at Days 1 and 21) with or without MF59 and enrolled in an immunology substudy. Responses were assessed at multiple timepoints (Days 0, 8, 21, 29, and 42) for hemagglutination inhibition (HAI) and neutralizing antibody (Neut) assays, memory B cell responses by enzyme-linked ImmunoSpot; circulating follicular helper T cells (cT FH ) and CD4 + T cells by intracellular cytokine staining., Results: MF59-adjuvanted influenza A/H7N9 vaccine induced significantly higher hemagglutination inhibition (HAI) and neutralizing antibody (Neut) responses when compared to unadjuvanted vaccine. The adjuvanted vaccine elicited significantly higher levels of Inducible T-cell Co-Stimulator (ICOS) expression by CXCR3 + CXCR5 + CD4 + cT FH cells, compared to unadjuvanted vaccine. The magnitude of increase in cT FH cells (from baseline to Day 8) and in IL-21 expressing CD154 + CD4 + T cells (from baseline to Days 8 and 21) correlated with HAI (at Day 29) and Neut antibody (at Days 8 and 29) titers. The increase in frequency of IL-21 expressing CD154 + CD4 + T cells (from baseline to Day 21) correlated with memory B cell frequency (at Day 42)., Conclusion: cT FH activation is associated with HAI and Neut responses in recipients of MF59-adjuvanted influenza A/H7N9 vaccine relative to unadjuvanted vaccine. Future studies should focus on optimizing the cT FH response and use cT FH as an early biomarker of serological response to vaccination. This trial was registered at clinicaltrials.gov, trial number NCT01938742., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results