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2. Discovery of a novel, potent, and specific family of factor Xa inhibitors via combinatorial chemistry

Author

Ostrem, James A., Al-Obeidi, Fahad, Safar, Pavel, Safarova, Alena, Stringer, Steven K., Patek, Marcel, Cross, M. Todd, Spoonamore, James, LoCascio, Jeff C., and Kasireddy, Padmaja

Subjects
Peptides -- Research, Blood coagulation factors -- Research, Hemostasis -- Research, Biological sciences, Chemistry
Abstract

Low molecular weight peptide inhibitors of factor Xa, important in the hemostatic mechanism, were identified by screening a combinatorial peptide library composed of L-amino acids. The peptides were modified into peptide mimetics with a greater than 1000-fold increase in potency while retaining unusual selectivity for factor Xa. Results suggested the potential uses of these peptides in anticoagulant therapy.

Published
1998

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