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1. Bioimpedance-derived body composition parameters predict mortality and dose-limiting toxicity: the multicenter ONCO-BIVA study

Author

Caccialanza, Riccardo, Cereda, Emanuele, Casirati, Amanda, Crotti, Silvia, Masi, Sara, Klersy, Catherine, Ferrari, Alessandra, Pedrazzoli, Paolo, Gavazzi, Cecilia, Vandoni, Giulia, Farina, Gabriella, La Verde, Nicla, Zagonel, Vittorina, Nardi, Maria Teresa, Baldan, Ilaria, Di Costanzo, Francesco, Mascheroni, Annalisa, Trestini, Ilaria, Valoriani, Filippo, Lucchin, Lucio, Aprile, Giuseppe, De Francesco, Antonella, Agnello, Elena, Giovanardi, Filippo, Cereda, E., Casirati, A., Klersy, C., Nardi, M., Vandoni, G., Agnello, E., Crotti, S., Masi, S., Ferrari, A., Pedrazzoli, P., and Caccialanza, R.

Published
2024
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2. Short-term Evolution of Nutritional Status in Patients with Idiopathic Pulmonary Fibrosis

Author

Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Lanzi, P, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, Busnelli, S, Paciocco, G, Lettieri, S, Mantovani, L, Cesana, G, Pesci, A, Luppi, F, Faverio, Paola, Fumagalli, Alessia, Conti, Sara, Madotto, Fabiana, Bini, Francesco, Harari, Sergio, Mondoni, Michele, Oggionni, Tiberio, Barisione, Emanuela, Ceruti, Paolo, Papetti, Maria Chiara, Bodini, Bruno Dino, Caminati, Antonella, Valentino, Angela, Centanni, Stefano, Lanzi, Paola, Della Zoppa, Matteo, Crotti, Silvia, Grosso, Marco, Sukkar, Samir Giuseppe, Modina, Denise, Andreoli, Marco, Nicali, Roberta, Suigo, Giulia, Busnelli, Sara, Paciocco, Giuseppe, Lettieri, Sara, Mantovani, Lorenzo Giovanni, Cesana, Giancarlo, Pesci, Alberto, Luppi, Fabrizio, Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Lanzi, P, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, Busnelli, S, Paciocco, G, Lettieri, S, Mantovani, L, Cesana, G, Pesci, A, Luppi, F, Faverio, Paola, Fumagalli, Alessia, Conti, Sara, Madotto, Fabiana, Bini, Francesco, Harari, Sergio, Mondoni, Michele, Oggionni, Tiberio, Barisione, Emanuela, Ceruti, Paolo, Papetti, Maria Chiara, Bodini, Bruno Dino, Caminati, Antonella, Valentino, Angela, Centanni, Stefano, Lanzi, Paola, Della Zoppa, Matteo, Crotti, Silvia, Grosso, Marco, Sukkar, Samir Giuseppe, Modina, Denise, Andreoli, Marco, Nicali, Roberta, Suigo, Giulia, Busnelli, Sara, Paciocco, Giuseppe, Lettieri, Sara, Mantovani, Lorenzo Giovanni, Cesana, Giancarlo, Pesci, Alberto, and Luppi, Fabrizio

Published
2023

9. Communication and visiting policies in Italian intensive care units during the first COVID-19 pandemic wave and lockdown: a nationwide survey

Author

Langer, T, Depalo, F, Forlini, C, Landini, S, Mezzetti, A, Previtali, P, Monti, G, de Toma, C, Biscardi, D, Giannini, A, Fumagalli, R, Mistraletti, G, Lissoni, B, De Martini, A, Mareto, N, Rossitto, C, Zummo, U, Taverna, M, Machieraldo, P, Navarra, M, Parlanti Garbero, M, Scaletti, C, Perno, S, Amendolia, L, Montrucchio, G, Veliaj, D, Barbarello, G, Alesci, M, Bolgiaghi, L, Vailati, D, Pezzi, A, Boselli, E, Piccoli, F, Greco, M, Gemma, M, Resta, M, Crotti, S, Bottino, N, Abruzzese, C, Savioli, M, Migliorino, G, Muttini, S, Umbrello, M, Borghi, B, Greco, S, Dizeo, M, Bottiroli, M, Mondino, M, Prosepri, M, Casella, G, Curto, F, Zaniboni, M, Giudici, R, Gentile, C, Bombino, M, Rona, R, Cortinovis, B, Benini, A, Avalli, L, Tavola, M, Ferrario, M, Preda, R, Primerano, E, Russo, G, Porta, V, Valdambrini, F, Fassini, P, Orando, S, Beck, E, Pedeferri, M, Cogliati, G, Testini, D, Moroni, B, Codeluppi, V, Ruggeri, P, Milanesi, E, Belliato, M, Besozzi, A, Riccio, M, Zerbi, S, Corbella, D, Ferri, F, Grazioli, L, Bonanomi, E, Giacomini, M, Sacchi, N, Codognola, C, Ambrosini, A, Guatteri, L, Subert, M, Castelli, G, Borelli, M, Venier, E, Dittura, L, Buttera, S, Bigai, R, Magnoni, S, Rauch, S, Colombo, A, Fullin, G, Donolato, C, Cattin, S, State, V, Redeghieri, E, Russo, A, Pastorini, S, Allena, S, Munari, M, Turchet, F, Peta, M, De Santis, V, Scala, C, Facondini, F, Marangoni, E, Tassinati, T, Zanzani, C, Russo, E, Marchio, A, Barbagallo, M, Girardis, M, Taffache, P, Mordacci, M, Vincenzi, M, Pennica, M, Bracciotti, G, Iori, P, Gambi, D, Cappellini, I, Vegnuti, L, De Luca, A, Romagnoli, S, Mosti, G, Carla, R, Roticiani, V, Pelagalli, L, Fuselli, E, D’Avino, E, De Bellis, M, Gianni, G, Leonardis, F, Rossi, M, Lorusso, R, Magnanimi, E, Martelli, S, Baisi, F, Balsamo, D, Cotticelli, V, Mattei, A, Farinelli, I, Riccini, T, Cola, L, Jorio, A, Iacobone, E, Domizi, R, Pizzi, S, Nasso, A, Graziani, R, Monaco, A, Manno, M, Ottelio, C, Del Rio, M, Serra, A, Enna, B, Loddo, F, Galbiati, R, Mellea, S, Kimberly, M, Vissani, M, Romito, F, Baccari, L, Zarrillo, N, Esposito, C, Murino, P, Notaro, S, Ausiello, C, Marra, A, Policastro, C, Cafora, C, De Benedectis, G, Di Falco, V, Sciddurlo, M, Negro, G, Vetuschi, P, Recchia, A, Pasquariello, R, Squillace, R, Ciambrone, A, Bencivenga, C, Camiolo, M, Agozzino, C, Oliveri, F, Notarrigo, T, Castiglione, G, Mo, A, Condorelli, L, Favarato, M, Langer, Thomas, Depalo, Francesca Carmela, Forlini, Clarissa, Landini, Silvia, Mezzetti, Andrea, Previtali, Paola, Monti, Gianpaola, de Toma, Carolina, Biscardi, Davide, Giannini, Alberto, Fumagalli, Roberto, Mistraletti, Giovanni, Lissoni, Barbara, De Martini, Andrea, Mareto, Nadia, Rossitto, Concetta, Zummo, Ugo, Taverna, Martina, Machieraldo, Patrizia, Navarra, Mauro, Parlanti Garbero, Massimiliano, Scaletti, Chiara, Perno, Silvia, Amendolia, Luca, Montrucchio, Giuseppe, Veliaj, Deliana, Barbarello, Giuseppe, Alesci, Maria, Bolgiaghi, Luca, Vailati, Davide, Pezzi, Angelo, Boselli, Enrico, Piccoli, Francesca, Greco, Massimiliano, Gemma, Marco, Resta, Marco, Crotti, Stefania, Bottino, Nicola, Abruzzese, Chiara, Savioli, Monica, Migliorino, Giuseppina, Muttini, Stefano, Umbrello, Michele, Borghi, Beatrice, Greco, Stefano, Dizeo, Micaela, Bottiroli, Maurizio, Mondino, Michele Giovanni, Prosepri, Manlio, Casella, Giampaolo, Curto, Francesco, Zaniboni, Matteo, Giudici, Riccardo, Gentile, Carlo, Bombino, Michela, Rona, Roberto, Cortinovis, Barbara, Benini, Annalisa, Avalli, Leonello, Tavola, Mario, Ferrario, Matteo, Preda, Roberta, Primerano, Enzo, Russo, Gianluca, Porta, Virginia, Valdambrini, Federico, Fassini, Paola, Orando, Serena, Beck, Eduardo, Pedeferri, Matteo, Cogliati, Giacomina, Testini, Denise, Moroni, Benedetta, Codeluppi, Vito, Ruggeri, Patrizia, Milanesi, Elisa, Belliato, Mirko, Besozzi, Alessandra, Riccio, Mario, Zerbi, Silvia, Corbella, Davide, Ferri, Francesco, Grazioli, Lorenzo, Bonanomi, Ezio, Giacomini, Matteo, Sacchi, Noemi, Codognola, Cristian, Ambrosini, Alessandra, Guatteri, Luca, Subert, Matteo, Castelli, Gian Paolo, Borelli, Massimo, Venier, Erica, Dittura, Loredana, Buttera, Stefania, Bigai, Roberto, Magnoni, Sandra, Rauch, Simon, Colombo, Angelo, Fullin, Giorgio, Donolato, Caterina, Cattin, Silvia, State, Veronica, Redeghieri, Enrico, Russo, Alessandro, Pastorini, Simonetta, Allena, Sandra, Munari, Marina, Turchet, Federica, Peta, Mario, De Santis, Vincenzo, Scala, Cristina, Facondini, Francesca, Marangoni, Elisabetta, Tassinati, Tania, Zanzani, Chiara, Russo, Emanuele, Marchio, Annamaria, Barbagallo, Maria, Girardis, Massimo, Taffache, Paolo, Mordacci, Marco, Vincenzi, Matteo, Pennica, Michele, Bracciotti, Giovanna, Iori, Paola, Gambi, Davide, Cappellini, Iacopo, Vegnuti, Lara, De Luca, Alessandra, Romagnoli, Stefano, Mosti, Giamila, Carla, Rossella, Roticiani, Valeria, Pelagalli, Lorella, Fuselli, Ennio, D’Avino, Emilio, De Bellis, Massimo, Gianni, Giulia, Leonardis, Francesca, Rossi, Marzia, Lorusso, Rossana, Magnanimi, Eugenia, Martelli, Sabrina, Baisi, Floriana, Balsamo, Davide, Cotticelli, Virginia, Mattei, Alessia, Farinelli, Ivano, Riccini, Teresa, Cola, Luisanna, Jorio, Antonella, Iacobone, Emanuele, Domizi, Roberta, Pizzi, Simone, Nasso, Armando, Graziani, Romano, Monaco, Anna, Manno, Manuela, Ottelio, Carla Maria, Del Rio, Michela, Serra, Antonio, Enna, Barbara, Loddo, Francesco Marco, Galbiati, Rita, Mellea, Serena, Kimberly, Michelle Brozzi, Vissani, Matteo, Romito, Francesco Massimo, Baccari, Laura, Zarrillo, Nadia, Esposito, Clelia, Murino, Patrizia, Notaro, Salvatore, Ausiello, Carmine, Marra, Annachiara, Policastro, Carmela, Cafora, Chiara, De Benedectis, Giuseppe, Di Falco, Vincenzo, Sciddurlo, Maria, Negro, Giancarlo, Vetuschi, Paolo, Recchia, Andrea, Pasquariello, Rita, Squillace, Rosalba, Ciambrone, Antonio, Bencivenga, Carmela, Camiolo, Melania, Agozzino, Cristina, Oliveri, Francesco, Notarrigo, Tiziana, Castiglione, Giacomo, Mo, Antonella, Condorelli, Laura, Favarato, Martina, Langer, T, Depalo, F, Forlini, C, Landini, S, Mezzetti, A, Previtali, P, Monti, G, de Toma, C, Biscardi, D, Giannini, A, Fumagalli, R, Mistraletti, G, Lissoni, B, De Martini, A, Mareto, N, Rossitto, C, Zummo, U, Taverna, M, Machieraldo, P, Navarra, M, Parlanti Garbero, M, Scaletti, C, Perno, S, Amendolia, L, Montrucchio, G, Veliaj, D, Barbarello, G, Alesci, M, Bolgiaghi, L, Vailati, D, Pezzi, A, Boselli, E, Piccoli, F, Greco, M, Gemma, M, Resta, M, Crotti, S, Bottino, N, Abruzzese, C, Savioli, M, Migliorino, G, Muttini, S, Umbrello, M, Borghi, B, Greco, S, Dizeo, M, Bottiroli, M, Mondino, M, Prosepri, M, Casella, G, Curto, F, Zaniboni, M, Giudici, R, Gentile, C, Bombino, M, Rona, R, Cortinovis, B, Benini, A, Avalli, L, Tavola, M, Ferrario, M, Preda, R, Primerano, E, Russo, G, Porta, V, Valdambrini, F, Fassini, P, Orando, S, Beck, E, Pedeferri, M, Cogliati, G, Testini, D, Moroni, B, Codeluppi, V, Ruggeri, P, Milanesi, E, Belliato, M, Besozzi, A, Riccio, M, Zerbi, S, Corbella, D, Ferri, F, Grazioli, L, Bonanomi, E, Giacomini, M, Sacchi, N, Codognola, C, Ambrosini, A, Guatteri, L, Subert, M, Castelli, G, Borelli, M, Venier, E, Dittura, L, Buttera, S, Bigai, R, Magnoni, S, Rauch, S, Colombo, A, Fullin, G, Donolato, C, Cattin, S, State, V, Redeghieri, E, Russo, A, Pastorini, S, Allena, S, Munari, M, Turchet, F, Peta, M, De Santis, V, Scala, C, Facondini, F, Marangoni, E, Tassinati, T, Zanzani, C, Russo, E, Marchio, A, Barbagallo, M, Girardis, M, Taffache, P, Mordacci, M, Vincenzi, M, Pennica, M, Bracciotti, G, Iori, P, Gambi, D, Cappellini, I, Vegnuti, L, De Luca, A, Romagnoli, S, Mosti, G, Carla, R, Roticiani, V, Pelagalli, L, Fuselli, E, D’Avino, E, De Bellis, M, Gianni, G, Leonardis, F, Rossi, M, Lorusso, R, Magnanimi, E, Martelli, S, Baisi, F, Balsamo, D, Cotticelli, V, Mattei, A, Farinelli, I, Riccini, T, Cola, L, Jorio, A, Iacobone, E, Domizi, R, Pizzi, S, Nasso, A, Graziani, R, Monaco, A, Manno, M, Ottelio, C, Del Rio, M, Serra, A, Enna, B, Loddo, F, Galbiati, R, Mellea, S, Kimberly, M, Vissani, M, Romito, F, Baccari, L, Zarrillo, N, Esposito, C, Murino, P, Notaro, S, Ausiello, C, Marra, A, Policastro, C, Cafora, C, De Benedectis, G, Di Falco, V, Sciddurlo, M, Negro, G, Vetuschi, P, Recchia, A, Pasquariello, R, Squillace, R, Ciambrone, A, Bencivenga, C, Camiolo, M, Agozzino, C, Oliveri, F, Notarrigo, T, Castiglione, G, Mo, A, Condorelli, L, Favarato, M, Langer, Thomas, Depalo, Francesca Carmela, Forlini, Clarissa, Landini, Silvia, Mezzetti, Andrea, Previtali, Paola, Monti, Gianpaola, de Toma, Carolina, Biscardi, Davide, Giannini, Alberto, Fumagalli, Roberto, Mistraletti, Giovanni, Lissoni, Barbara, De Martini, Andrea, Mareto, Nadia, Rossitto, Concetta, Zummo, Ugo, Taverna, Martina, Machieraldo, Patrizia, Navarra, Mauro, Parlanti Garbero, Massimiliano, Scaletti, Chiara, Perno, Silvia, Amendolia, Luca, Montrucchio, Giuseppe, Veliaj, Deliana, Barbarello, Giuseppe, Alesci, Maria, Bolgiaghi, Luca, Vailati, Davide, Pezzi, Angelo, Boselli, Enrico, Piccoli, Francesca, Greco, Massimiliano, Gemma, Marco, Resta, Marco, Crotti, Stefania, Bottino, Nicola, Abruzzese, Chiara, Savioli, Monica, Migliorino, Giuseppina, Muttini, Stefano, Umbrello, Michele, Borghi, Beatrice, Greco, Stefano, Dizeo, Micaela, Bottiroli, Maurizio, Mondino, Michele Giovanni, Prosepri, Manlio, Casella, Giampaolo, Curto, Francesco, Zaniboni, Matteo, Giudici, Riccardo, Gentile, Carlo, Bombino, Michela, Rona, Roberto, Cortinovis, Barbara, Benini, Annalisa, Avalli, Leonello, Tavola, Mario, Ferrario, Matteo, Preda, Roberta, Primerano, Enzo, Russo, Gianluca, Porta, Virginia, Valdambrini, Federico, Fassini, Paola, Orando, Serena, Beck, Eduardo, Pedeferri, Matteo, Cogliati, Giacomina, Testini, Denise, Moroni, Benedetta, Codeluppi, Vito, Ruggeri, Patrizia, Milanesi, Elisa, Belliato, Mirko, Besozzi, Alessandra, Riccio, Mario, Zerbi, Silvia, Corbella, Davide, Ferri, Francesco, Grazioli, Lorenzo, Bonanomi, Ezio, Giacomini, Matteo, Sacchi, Noemi, Codognola, Cristian, Ambrosini, Alessandra, Guatteri, Luca, Subert, Matteo, Castelli, Gian Paolo, Borelli, Massimo, Venier, Erica, Dittura, Loredana, Buttera, Stefania, Bigai, Roberto, Magnoni, Sandra, Rauch, Simon, Colombo, Angelo, Fullin, Giorgio, Donolato, Caterina, Cattin, Silvia, State, Veronica, Redeghieri, Enrico, Russo, Alessandro, Pastorini, Simonetta, Allena, Sandra, Munari, Marina, Turchet, Federica, Peta, Mario, De Santis, Vincenzo, Scala, Cristina, Facondini, Francesca, Marangoni, Elisabetta, Tassinati, Tania, Zanzani, Chiara, Russo, Emanuele, Marchio, Annamaria, Barbagallo, Maria, Girardis, Massimo, Taffache, Paolo, Mordacci, Marco, Vincenzi, Matteo, Pennica, Michele, Bracciotti, Giovanna, Iori, Paola, Gambi, Davide, Cappellini, Iacopo, Vegnuti, Lara, De Luca, Alessandra, Romagnoli, Stefano, Mosti, Giamila, Carla, Rossella, Roticiani, Valeria, Pelagalli, Lorella, Fuselli, Ennio, D’Avino, Emilio, De Bellis, Massimo, Gianni, Giulia, Leonardis, Francesca, Rossi, Marzia, Lorusso, Rossana, Magnanimi, Eugenia, Martelli, Sabrina, Baisi, Floriana, Balsamo, Davide, Cotticelli, Virginia, Mattei, Alessia, Farinelli, Ivano, Riccini, Teresa, Cola, Luisanna, Jorio, Antonella, Iacobone, Emanuele, Domizi, Roberta, Pizzi, Simone, Nasso, Armando, Graziani, Romano, Monaco, Anna, Manno, Manuela, Ottelio, Carla Maria, Del Rio, Michela, Serra, Antonio, Enna, Barbara, Loddo, Francesco Marco, Galbiati, Rita, Mellea, Serena, Kimberly, Michelle Brozzi, Vissani, Matteo, Romito, Francesco Massimo, Baccari, Laura, Zarrillo, Nadia, Esposito, Clelia, Murino, Patrizia, Notaro, Salvatore, Ausiello, Carmine, Marra, Annachiara, Policastro, Carmela, Cafora, Chiara, De Benedectis, Giuseppe, Di Falco, Vincenzo, Sciddurlo, Maria, Negro, Giancarlo, Vetuschi, Paolo, Recchia, Andrea, Pasquariello, Rita, Squillace, Rosalba, Ciambrone, Antonio, Bencivenga, Carmela, Camiolo, Melania, Agozzino, Cristina, Oliveri, Francesco, Notarrigo, Tiziana, Castiglione, Giacomo, Mo, Antonella, Condorelli, Laura, and Favarato, Martina

Abstract

Background: During the first coronavirus disease 2019 (COVID-19) pandemic wave, an unprecedented number of patients with respiratory failure due to a new, highly contagious virus needed hospitalization and intensive care unit (ICU) admission. The aim of the present study was to describe the communication and visiting policies of Italian intensive care units (ICUs) during the first COVID-19 pandemic wave and national lockdown and compare these data with prepandemic conditions. Methods: A national web-based survey was conducted among 290 Italian hospitals. Each ICU (active between February 24 and May 31, 2020) was encouraged to complete an individual questionnaire inquiring the hospital/ICU structure/organization, communication/visiting habits and the role of clinical psychology prior to, and during the first COVID-19 pandemic wave. Results: Two hundred and nine ICUs from 154 hospitals (53% of the contacted hospitals) completed the survey (202 adult and 7 pediatric ICUs). Among adult ICUs, 60% were dedicated to COVID-19 patients, 21% were dedicated to patients without COVID-19 and 19% were dedicated to both categories (Mixed). A total of 11,102 adult patients were admitted to the participating ICUs during the study period and only approximately 6% of patients received at least one visit. Communication with family members was guaranteed daily through an increased use of electronic devices and was preferentially addressed to the same family member. Compared to the prepandemic period, clinical psychologists supported physicians more often regarding communication with family members. Fewer patients received at least one visit from family members in COVID and mixed-ICUs than in non-COVID ICUs, l (0 [0-6]%, 0 [0-4]% and 11 [2-25]%, respectively, p < 0.001). Habits of pediatric ICUs were less affected by the pandemic. Conclusions: Visiting policies of Italian ICUs dedicated to adult patients were markedly altered during the first COVID-19 wave. Remote communication was wi

Published
2022

10. Sarcopenia in idiopathic pulmonary fibrosis: a prospective study exploring prevalence, associated factors and diagnostic approach

Author

Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Lanzi, P, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, Busnelli, S, Paciocco, G, Lettieri, S, Mantovani, L, Cesana, G, Pesci, A, Luppi, F, Faverio, Paola, Fumagalli, Alessia, Conti, Sara, Madotto, Fabiana, Bini, Francesco, Harari, Sergio, Mondoni, Michele, Oggionni, Tiberio, Barisione, Emanuela, Ceruti, Paolo, Papetti, Maria Chiara, Bodini, Bruno Dino, Caminati, Antonella, Valentino, Angela, Centanni, Stefano, Lanzi, Paola, Della Zoppa, Matteo, Crotti, Silvia, Grosso, Marco, Sukkar, Samir Giuseppe, Modina, Denise, Andreoli, Marco, Nicali, Roberta, Suigo, Giulia, Busnelli, Sara, Paciocco, Giuseppe, Lettieri, Sara, Mantovani, Lorenzo Giovanni, Cesana, Giancarlo, Pesci, Alberto, Luppi, Fabrizio, Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Lanzi, P, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, Busnelli, S, Paciocco, G, Lettieri, S, Mantovani, L, Cesana, G, Pesci, A, Luppi, F, Faverio, Paola, Fumagalli, Alessia, Conti, Sara, Madotto, Fabiana, Bini, Francesco, Harari, Sergio, Mondoni, Michele, Oggionni, Tiberio, Barisione, Emanuela, Ceruti, Paolo, Papetti, Maria Chiara, Bodini, Bruno Dino, Caminati, Antonella, Valentino, Angela, Centanni, Stefano, Lanzi, Paola, Della Zoppa, Matteo, Crotti, Silvia, Grosso, Marco, Sukkar, Samir Giuseppe, Modina, Denise, Andreoli, Marco, Nicali, Roberta, Suigo, Giulia, Busnelli, Sara, Paciocco, Giuseppe, Lettieri, Sara, Mantovani, Lorenzo Giovanni, Cesana, Giancarlo, Pesci, Alberto, and Luppi, Fabrizio

Abstract

Background: Sarcopenia gained importance in the evaluation of patients with chronic respiratory diseases, including idiopathic pulmonary fibrosis (IPF), since it may impact negatively on clinical outcomes. Aim: Aim of this study is to evaluate the prevalence and factors associated with sarcopenia, defined according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) 2019 definition, and to evaluate the prevalence of the single criteria that define the EWGSOP2 definition (muscle strength, muscle quantity and physical performance), in a cohort of consecutive patients with IPF prospectively followed up in 9 hospitals in Northern Italy between December 2018 and May 2021. Methods: Enrolled patients underwent an extensive pulmonary and nutritional assessment, including bioelectrical impedance analysis, dynamometry and 4-m gait speed test, both at IPF diagnosis and at 6-month follow-up. Results: Out of the 83 patients (81% males, mean age 72.5 years) with IPF at disease diagnosis enrolled in the study, 19 (22.9%) showed sarcopenia, including 2 (2.4%) with severe sarcopenia, 5 (6.0%) with confirmed sarcopenia and 12 (14.5%) with probable sarcopenia. Sarcopenia was associated with a significantly higher severity of the disease and sedentary lifestyle, while no differences were observed in regards to body mass index, history of weight loss and comorbidities between patients with and without sarcopenia. Out of the 64 patients without sarcopenia at baseline, 16 cases showed alteration of muscle quantity and/or physical performance. In the 51 patients with complete data at 6-month follow-up, there were no cases of severe sarcopenia, 1 case (2.0%) showed confirmed sarcopenia, while the prevalence of probable sarcopenia was 19.6% (10 cases). No differences in regards to antifibrotic treatment received and onset of gastrointestinal side effects were observed between patients with and without sarcopenia at follow-up. Conclusions: The prevalence of sarcopenia in p

Published
2022

14. Nutritional parameters associated with prognosis in non-critically ill hospitalized covid-19 patients: the nutri-covid19 study

Author

Cereda, E., primary, Formisano, E., additional, Klersy, C., additional, Ferretti, V., additional, Masi, S., additional, Crotti, S., additional, Ferrari, A., additional, Lobascio, F., additional, Demontis, S., additional, Mascheroni, A., additional, Cerutti, N., additional, Orlandoni, P., additional, Costa, C. Dalla, additional, Redaelli, E., additional, Fabbri, A., additional, Malesci, A., additional, Corrao, S., additional, Bordandini, L., additional, and Caccialanza, R., additional

Published
2021
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16. Matter of margins

Author

Gualdi, G., Monari, P., Crotti, S., Damiani, G., Facchetti, F., Calzavara-Pinton, P., and Fantini, F.

Published
2015
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17. 925TiP The efficacy of immunonutrition in improving tolerance to chemoradiotherapy in patients with head and neck cancer, receiving nutritional counseling: Study protocol of a randomized, open-label, parallel group, bicentric pilot study

Author

Tancredi, R., primary, Cereda, E., additional, Klersy, C., additional, Nardi, M.T., additional, Masi, S., additional, Crotti, S., additional, Caissutti, V., additional, Brovia, C., additional, Bonzano, E., additional, Comoli, P., additional, Catenacci, L., additional, Imarisio, I., additional, Bossi, P., additional, Ghi, M.G., additional, Pedrazzoli, P., additional, and Caccialanza, R., additional

Published
2021
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18. Tryptophan in health and disease

Author

Comai S., Bertazzo A., Brughera M., Crotti S., Comai, S., Bertazzo, A., Brughera, M., and Crotti, S.

Subjects
Physiology, Tryptophan, Inflammatory Bowel Diseases, Cancer, Disease, Neurological disorders, Psychiatric disorders, Cardiovascular Diseases, Central Nervous System Diseases, Health, Neoplasms, Animals, Humans
Abstract

Tryptophan (TRP), an essential amino acid in mammals, is involved in several physiological processes including neuronal function, immunity, and gut homeostasis. In humans, TRP is metabolized via the kynurenine and serotonin pathways, leading to the generation of biologically active compounds, such as serotonin, melatonin and niacin. In addition to endogenous TRP metabolism, resident gut microbiota also contributes to the production of specific TRP metabolites and indirectly influences host physiology. The variety of physiologic functions regulated by TRP reflects the complex pattern of diseases associated with altered homeostasis. Indeed, an imbalance in the synthesis of TRP metabolites has been associated with pathophysiologic mechanisms occurring in neurologic and psychiatric disorders, in chronic immune activation and in the immune escape of cancer. In this chapter, the role of TRP metabolism in health and disease is presented. Disorders involving the central nervous system, malignancy, inflammatory bowel and cardiovascular disease are discussed.

Published
2020

19. Nutritional assessment in idiopathic pulmonary fibrosis: a prospective multicentre study

Author

Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Noè, D, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, De Giacomi, F, Busnelli, S, Cattaneo, E, Mantovani, L, Cesana, G, Pesci, A, Luppi, F, Faverio, P, Fumagalli, A, Conti, S, Madotto, F, Bini, F, Harari, S, Mondoni, M, Oggionni, T, Barisione, E, Ceruti, P, Papetti, M, Bodini, B, Caminati, A, Valentino, A, Centanni, S, Noè, D, Della Zoppa, M, Crotti, S, Grosso, M, Sukkar, S, Modina, D, Andreoli, M, Nicali, R, Suigo, G, De Giacomi, F, Busnelli, S, Cattaneo, E, Mantovani, L, Cesana, G, Pesci, A, and Luppi, F

Abstract

Background. Nutritional status (NS) impacts on quality of life and prognosis of patients with respiratory diseases including idiopathic pulmonary fibrosis (IPF). However, there is a lack of studies performing an extensive nutritional assessment of IPF patients. This study aims to investigate the NS and to identify nutritional phenotypes in a cohort of IPF patients at diagnosis. Methods. Patients underwent a thorough pulmonary and nutritional evaluation including questionnaires on NS and physical activity, anthropometry, body impedence, dynamometry, 4- meter gait speed and blood tests. Results. 90 IPF patients (78.9% males, mean age 72.7 years) were enrolled. The majority of patients were classified as Gender-Age-Physiology Index stage 2 (47, 52.2%) with an inactive lifestyle according to International Physical Activity Questionnaire score (39, 43.3%) and had mean forced vital capacity and diffusing capacity for carbon monoxide 86.5% and 54.2%, respectively. In regards to nutritional phenotypes, the majority of patients were normally nourished (67.8%, 95% Confidence Interval (CI):58.6-77.7), followed by non-sarcopenic obese (25.3%, 95%CI:16.1-35.2), sarcopenic (4.6%, 95%CI:0.0-14.5) and sarcopenic obese (2.3%, 95%CI:0.0-12.2). Among normally nourished, 49.2% showed early signs of nutritional and physical performance alterations, including body mass index≥ 30 in 4.3%, history of weight loss≥ 5% in 11.9%, reduction of gait speed and hand grip strength in 11.9% and 35.6%, respectively. Low vitamin D values were observed in 56.3% of cases. Conclusions. IPF patients at diagnosis are mainly normally nourished and obese, but early signs of nutritional and physical performance impairment can already be identified at this stage.

Published
2021

21. Contributors

Author

Aturki, Z., primary, Bohni, N., additional, Cavazzini, A., additional, Crotti, S., additional, D’Orazio, G., additional, Dolan, J.W., additional, Edison, A.S., additional, Fanali, S., additional, Felinger, A., additional, Foret, F., additional, Fornstedt, T., additional, Forssén, P., additional, García-Álvarez-Coque, M.C., additional, Isak, I., additional, Kaliszan, R., additional, Kaspereit, M., additional, Kuligowski, J., additional, Lamotte, S., additional, Lendl, B., additional, Machtejevas, E., additional, Macka, M., additional, Ndjoko-Ioset, K., additional, Nesterenko, P.N., additional, Paull, B., additional, Queiroz, J.A., additional, Quintás, G., additional, Ramis-Ramos, G., additional, Rocco, A., additional, Samuelsson, J., additional, Seidel-Morgenstern, A., additional, Shackman, J.G., additional, Smejkal, P., additional, Snyder, L.R., additional, Striegel, A.M., additional, Tomaz, C.T., additional, Torres-Lapasió, J.R., additional, Traldi, P., additional, Unger, K.K., additional, and Wolfender, J.-L., additional

Published
2013
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23. The need to reappraise the definition of sarcopenia in cancer patients

Author

Cereda, E., primary, Lobascio, F., additional, Crotti, S., additional, Masi, S., additional, Cappello, S., additional, Turri, A., additional, Borioli, V., additional, Klersy, C., additional, Stobäus, N., additional, Tank, M., additional, Franz, K., additional, Cutti, S., additional, Arcaini, L., additional, Filippi, A.R., additional, Benazzo, M., additional, Palladini, G., additional, Pedrazzoli, P., additional, Norman, K., additional, and Caccialanza, R., additional

Published
2020
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24. Importance of body composition in grading body mass index and weight loss-related nutritional risk in cancer patients

Author

Cereda, E., primary, Lobascio, F., additional, Masi, S., additional, Crotti, S., additional, Cappello, S., additional, Borioli, V., additional, Turri, A., additional, Klersy, C., additional, Stobäus, N., additional, Tank, M., additional, Franz, K., additional, Cutti, S., additional, Giaquinto, E., additional, Benazzo, M., additional, Filippi, A.R., additional, Arcaini, L., additional, Palladini, G., additional, Pedrazzoli, P., additional, Norman, K., additional, and Caccialanza, R., additional

Published
2020
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26. Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: Irinotecan and sunitinib

Author

Vercelli B., Crotti S., and Agostini M.

Subjects
Ctclic Voltammetry, Aggregation Effects, Sunitinib, Irinotecan
Abstract

The voltammetric responses of two anticancer molecules irinotecan (ITC) and sunitinib (SUN) were investigated at glassy carbon (GC) and indium tin oxide (ITO) electrodes bare or modified with carbon nanotubes (NTs), NT-Nafion composites (NafionNTs) and poly(3,4-ethylenedioxy-thiophene) (PEDOT). Bare GC electrodes revealed to be the most suitable for the detection of drugs at low concentration levels. Differential pulse voltammetry (DPV) analyses showed that the responses of the anticancer molecules are affected by the formation of aggregates. In particular, aggregation of SUN results in the formation of H-aggregates. DPV analysis extended to human plasma samples revealed the drugs in micromolar concentrations with good reproducibility.

Published
2020
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27. Free Papers

Author

Matamis, D., Lagonidis, D., Tsagourias, M., Riggos, D., Pelosi, P., Croci, M., Chiumello, D., Gattinoni, L., Borelli, M., Lampati, L., Vascotto, E., Verweij, M., Brambilla, R., Elia, S., Pesenti, A., Reissmann, H., Katzenstein, O., Prause, A., Fuellekrug, B., Pothmann, W., Brienza, N., Grasso, S., Bruno, F., Dambrosio, M., Cinnella, G., Ranieri, V. M., Lagioia, V., Brienza, A., Vaiĉiulis, K., Bagdonaviĉiené, T., Dapŝys, K., Žukauskas, G., Thys, F., Eggimann, P., Jolliet, P., Thouret, J. M., Pugin, J., Chevrolet, J. C., Max, M., Kaisers, U., Eichhorn, V., Böhm, S., Rossaint, R., Lachmann, B., Amaral, J. L. G., Ito, M. M., Munechika, M., Rouby, J-J., Amarante, G. A. J., Ferez, D., Mancebo, J., Albaladejo, P., Bak, E., Elatrous, S., Touchard, D., Subirana, M., Lemaire, F., Harf, A., Brochard, L., Aslanian, P., Lopez, G., Pérez, M., Betbesé, A. J., Rialp, G., Santos, J. A., Ballús, J., Net, A., Bonmarchand, G., Chevron, V., Lacoume, Y., Tamion, F., Girault, G., Temmesfeld, B., Günther, A., Walmrath, D., Siebert, C., Grimminger, F., Seeger, W., McBride, G. B., Lavery, G., Valenza, F., Pedoto, A., Crotti, S., Mascheroni, D., Gattinoni, L., Ruiz-Bailén, H., Colmenero-Ruiz, H., Cárdenas-Cruz, A., Navarrete-Sánchez, I., Bayona-Gómez, A., Fernández-Mondejar, E., Nekvasil, R., Trittenwein, R., and Fedora, M.

Published
1996
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29. Spontaneous Breathing Patterns During Maximum Extracorporeal CO2 Removal in Subjects With Early Severe ARDS

Author

Spinelli, E, Mauri, T, Lissoni, A, Crotti, S, Langer, T, Albanese, M, Volta, C, Fornari, C, Tagliabue, P, Grasselli, G, Pesenti, A, Spinelli, Elena, Mauri, Tommaso, Lissoni, Alfredo, Crotti, Stefania, Langer, Thomas, Albanese, Marco, Volta, Carlo Alberto, Fornari, Carla, Tagliabue, Paola, Grasselli, Giacomo, Pesenti, Antonio, Spinelli, E, Mauri, T, Lissoni, A, Crotti, S, Langer, T, Albanese, M, Volta, C, Fornari, C, Tagliabue, P, Grasselli, G, Pesenti, A, Spinelli, Elena, Mauri, Tommaso, Lissoni, Alfredo, Crotti, Stefania, Langer, Thomas, Albanese, Marco, Volta, Carlo Alberto, Fornari, Carla, Tagliabue, Paola, Grasselli, Giacomo, and Pesenti, Antonio

Abstract

BACKGROUND: Switching patients affected by early severe ARDS and undergoing extracorporeal membrane oxygenation (ECMO) from controlled ventilation to spontaneous breathing can be either beneficial or harmful, depending on how effectively the breathing pattern is controlled with ECMO. Identifying the factors associated with ineffective control of spontaneous breathing with ECMO may advance our pathophysiologic understanding of this syndrome. METHODS: We conducted a prospective study in subjects with severe ARDS who were on ECMO support ≤ 7 d. Subjects were switched to minimal sedation and pressure-support ventilation while extracorporeal CO2 removal was increased to approximate the subject’s total CO2 production ( _VCO2 ). We calculated the rapid shallow breathing index (RSBI) as breathing frequency divided by tidal volume. We explored the correlation between certain characteristics recorded during pretest controlled ventilation and the development of apnea (ie, expiratory pause lasting > 10 s; n 5 3), normal breathing pattern (ie, apnea to RSBI ≤ 105 breaths/ min/L; n 5 6), and rapid shallow breathing (RSBI > 105 breaths/min/L; n 5 6) that occurred during the test study. RESULTS: The ratio of extracorporeal CO2 removal to the subjects’ _VCO2 was >90% in all 15 subjects, and arterial blood gases remained within normal ranges. Baseline pretest Sequential Organ Failure Assessment score, total _VCO2 and ventilatory ratio increased steadily, whereas PaO2 /FIO2 was higher in subjects with apnea compared to intermediate RSBI ≤105 breaths/min/L and elevated RSBI >105 breaths/min/L. In subjects with rapid shallow breathing, baseline lung weight measured with quantitative computed tomography scored higher, as well. CONCLUSIONS: In early severe ARDS, the factors associated with rapid shallow breathing despite maximum extracorporeal CO2 extraction include less efficient CO2 and O2 exchange by the natural lung, higher severity of organ failure, and greater magnitude

Published
2020

32. Erratum to: Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer (Nature Genetics, (2018), 50, 2, (219-228), 10.1038/s41588-017-0026-3)

Author

Chen, J., Guccini, I., Di Mitri, D., Brina, D., Revandkar, A., Sarti, M., Pasquini, E., Alajati, A., Pinton, S., Losa, M., Civenni, G., Catapano, C. V., Sgrignani, J., Cavalli, A., D'Antuono, R., Asara, J. M., Morandi, A., Chiarugi, P., Crotti, S., Agostini, M., Montopoli, M., Masgras, I., Rasola, A., Garcia-Escudero, R., Delaleu, N., Rinaldi, A., Bertoni, F., de Bono, J., Carracedo, A., and Alimonti, A.

Published
2018

36. Alterations of the Plasma Peptidome Profiling in Colorectal Cancer Progression

Author

Bedin C., Crotti S., Ragazzi E., Pucciarelli S., Agatea L., Tasciotti E., Ferrari M., Traldi P., Rizzolio F., Giordano A., Nitti D., and Agostini M.

Subjects
CARCINOMA, METABOANALYST, PATTERNS, SERUM PEPTIDOME, DIAGNOSIS, METABOLOMIC DATA-ANALYSIS
Abstract

Early detection of colorectal cancer (CRC) remains a challenge. It has been highlighted that the pathological alterations within an organ and tissues might be reflected in serum or plasma proteomic/peptidic patterns. The aim of the study was to follow the changes in the plasma peptides associated to colorectal cancer progression by mass spectrometry. This study included 27 adenoma, 67 CRC (n=33 I-II stage and n=34 III-IV stage), 23 liver metastasis from CRC patients and 34 subjects disease-free as controls. For plasma peptides analysis, samples purification was performed on the Nanoporous Silica Chips technology followed by matrix-assisted laser desorption/ionisation-time of flight analysis. Since the high complexity of the obtained dataset, multivariate statistical analysis, and discriminant pattern recognition were performed for study groups classification. Forty-four of 88 ionic species were successfully identified as fragments of peptides and proteins physiologically circulating in the blood and belonging to immune and coagulation systems and inflammatory mediators. Many peptides clustered into sets of overlapping sequences with ladder-like truncation clearly associated to proteolytic processes of both endo- and exoproteases activity. Comparing to controls, a different median ion intensity of the group-type fragments distribution was observed. Moreover, the degradation pattern obtained by proteolytic cleavage was different into study groups. This pattern was specific and characteristic of each group: controls, colon tumour disease (including adenoma and CRC), and liver metastasis, revealing a role as biomarker in early diagnosis and prognosis. Our findings highlighted peculiar changes in protease activity characteristic of CRC progression from pre-cancer lesion to metastatic disease.

Published
2016
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38. Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score

Author

Pappalardo F, Pieri M, Greco T, Patroniti N, Pesenti A, Arcadipane A, Ranieri VM, Gattinoni L, Landoni G, Holzgraefe B, Beutel G, Zangrillo A, Italian E.C.M.O.n.e.t. Scandroglio AM, Calabrò MG, Bove T, De Bonis M, Foti G, Bombino M, Peris A, Cianchi G, Pasquini A, Braschi A, Mojoli F, Zanierato M, Iotti GA, Belliato M, Carnevale L, Terragni P, Urbino R, Del Sorbo L, Fanelli V, Panarello G, Antonelli M, Bello G, Maviglia R, Lissoni A, Crotti S, Pietropaoli P, Rocco M, Morelli A, Frascaroli G, Caramelli F, Bruno F, Grasso S, Lorini L, Ori C., TUFANO, ROSALBA, IANNUZZI, MICHELE, Pappalardo, F, Pieri, M, Greco, T, Patroniti, N, Pesenti, A, Arcadipane, A, Ranieri, V, Gattinoni, L, Landoni, G, Holzgraefe, B, Beutel, G, Zangrillo, A, Lorini, F, Ranieri, Vm, Federico Pappalardo, Marina Pieri, Teresa Greco, Nicolò Patroniti, Antonio Pesenti, Antonio Arcadipane, V. Marco Ranieri, Luciano Gattinoni, Giovanni Landoni, Bernhard Holzgraefe, Gernot Beutel, Alberto Zangrillo, Scandroglio AM, Italian E. C. M. O. n. e. t., Calabrò, Mg, Bove, T, De Bonis, M, Foti, G, Bombino, M, Peris, A, Cianchi, G, Pasquini, A, Braschi, A, Mojoli, F, Zanierato, M, Iotti, Ga, Belliato, M, Carnevale, L, Terragni, P, Urbino, R, Del Sorbo, L, Fanelli, V, Panarello, G, Antonelli, M, Bello, G, Maviglia, R, Lissoni, A, Crotti, S, Pietropaoli, P, Rocco, M, Morelli, A, Frascaroli, G, Caramelli, F, Tufano, Rosalba, Iannuzzi, Michele, Bruno, F, Grasso, S, Lorini, L, and Ori, C.

Subjects
Adult, Male, medicine.medical_specialty, ARDS, medicine.medical_treatment, ECMO -ARDS - H1N1, venovenous extracorporeal membrane oxygenation (VV ECMO), H1N1 virus, Critical Care and Intensive Care Medicine, Risk Assessment, Veins, Cohort Studies, Influenza A Virus, H1N1 Subtype, Acute respiratory distress syndrome, ECMO, Extracorporeal membrane oxygenation, Mortality, Multiple organ failure, Female, Humans, Influenza, Human, Prospective Studies, Respiratory Distress Syndrome, Adult, Survival Rate, Extracorporeal Membrane Oxygenation, Anesthesiology, Influenza A Virus, Medicine, H1N1 Subtype, MED/41 - ANESTESIOLOGIA, Intensive care medicine, Prospective cohort study, Survival rate, Respiratory Distress Syndrome, business.industry, medicine.disease, Influenza, ECMO: H1N1, Pneumonia, surgical procedures, operative, Respiratory failure, business, Cohort study, Human
Abstract

PURPOSE: The decision to start venovenous extracorporeal membrane oxygenation (VV ECMO) is commonly based on the severity of respiratory failure, with little consideration of the extrapulmonary organ function. The aim of the study was to identify predictors of mortality and to develop a score allowing a better stratification of patients at the time of VV ECMO initiation. METHODS: This was a prospective multicenter cohort study on 60 patients with influenza A (H1N1)-associated respiratory distress syndrome participating in the Italian ECMOnet data set in the 2009 pandemic. Criteria for ECMO institution were standardized according to national guidelines. RESULTS: The survival rate in patients treated with ECMO was 68%. Significant predictors of death before ECMO institution by multivariate analysis were hospital length of stay before ECMO institution (OR=1.52, 95% CI 1.12-2.07, p=0.008); bilirubin (OR=2.32, 95% CI 1.52-3.52, p&nbsp

Published
2013

40. The development of a matrix-assisted laser desorption/ionization (MALDI)-based analytical method for determination of irinotecan levels in human plasma: Preliminary results

Author

Calandra, E., Crotti, S., Nitti, D., Roverso, M., Toffoli, G., Marangon, E., Posocco, B., Traldi, P., and Agostini, M.

Subjects
SN38, Spectrometry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, ACTIVE METABOLITE, Matrix-Assisted Laser Desorption-Ionization, Humans, Camptothecin, Mass, QUANTIFICATION, Irinotecan, CHEMOEMBOLIZATION
Published
2015
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43. 'Awake' extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering

Author

Langer, T, Santini, A, Bottino, N, Crotti, S, Batchinsky, A, Pesenti, A, Gattinoni, L, Batchinsky, AI, Langer, T, Santini, A, Bottino, N, Crotti, S, Batchinsky, A, Pesenti, A, Gattinoni, L, and Batchinsky, AI

Abstract

Venovenous extracorporeal membrane oxygenation (vv-ECMO) has been classically employed as a rescue therapy for patients with respiratory failure not treatable with conventional mechanical ventilation alone. In recent years, however, the timing of ECMO initiation has been readdressed and ECMO is often started earlier in the time course of respiratory failure. Furthermore, some centers are starting to use ECMO as a first line of treatment, i.e., as an alternative to invasive mechanical ventilation in awake, non-intubated, spontaneously breathing patients with respiratory failure ("awake" ECMO). There is a strong rationale for this type of respiratory support as it avoids several side effects related to sedation, intubation, and mechanical ventilation. However, the complexity of the patient-ECMO interactions, the difficulties related to respiratory monitoring, and the management of an awake patient on extracorporeal support together pose a major challenge for the intensive care unit staff. Here, we review the use of vv-ECMO in awake, spontaneously breathing patients with respiratory failure, highlighting the pros and cons of this approach, analyzing the pathophysiology of patient-ECMO interactions, detailing some of the technical aspects, and summarizing the initial clinical experience gained over the past years.

Published
2016

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