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4. Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa

Author

Duncan, Laramie, Yilmaz, Zeynep, Gaspar, Helena, Walters, Raymond, Goldstein, Jackie, Anttila, Verneri, Bulik-Sullivan, Brendan, Ripke, Stephan, Thornton, Laura, Hinney, Anke, Daly, Mark, Sullivan, Patrick F, Zeggini, Eleftheria, Breen, Gerome, Bulik, Cynthia M, Gaspar, Héléna, Adan, Roger, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole, Aschauer, Harald, Baker, Jessica, Barrett, Jeffrey, Bencko, Vladimir, Bergen, Andrew, Berrettini, Wade, Birgegård, Andreas, Boni, Claudette, Perica, Vesna Boraska, Brandt, Harry, Burghardt, Roland, Carlberg, Laura, Cassina, Matteo, Cesta, Carolyn, Cichon, Sven, Clementi, Maurizio, Cohen-Woods, Sarah, Coleman, Joni, Cone, Roger, Courtet, Philippe, Crawford, Steven, Crow, Scott, Crowley, Jim, Danner, Unna, Davis, Oliver, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece, Dick, Danielle, Dikeos, Dimitris, Dina, Christian, Ding, Bo, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Egberts, Karin, Ehrlich, Stefan, Escaramís, Geòrgia, Esko, Tõnu, Espeseth, Thomas, Estivill, Xavier, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred, Finan, Chris, Fischer, Krista, Floyd, James, Föcker, Manuel, Foretova, Lenka, Forzan, Monica, Fox, Caroline, Franklin, Christopher, Gaborieau, Valerie, Gallinger, Steven, Gambaro, Giovanni, Giegling, Ina, Gonidakis, Fragiskos, Gorwood, Philip, Gratacos, Monica, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine, Harrison, Rebecca, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske, Hendriks, Judith, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, and Hilliard, Christopher

Subjects
Serious Mental Illness, Mental Health, Anorexia, Eating Disorders, Brain Disorders, Nutrition, Human Genome, Genetics, Prevention, Pediatric, Mental health, Anorexia Nervosa, Case-Control Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Phenotype, Polymorphism, Single Nucleotide, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Diabetes, GWAS, Metabolism, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

ObjectiveThe authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes.MethodFollowing uniform quality control and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3,495 anorexia nervosa cases and 10,982 controls, the authors performed standard association analysis followed by a meta-analysis across cohorts. Linkage disequilibrium score regression was used to calculate genome-wide common variant heritability (single-nucleotide polymorphism [SNP]-based heritability [h2SNP]), partitioned heritability, and genetic correlations (rg) between anorexia nervosa and 159 other phenotypes.ResultsResults were obtained for 10,641,224 SNPs and insertion-deletion variants with minor allele frequencies >1% and imputation quality scores >0.6. The h2SNP of anorexia nervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability arises from common genetic variation. The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previously reported type 1 diabetes and autoimmune disorder locus. Significant positive genetic correlations were observed between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density lipoprotein cholesterol, and significant negative genetic correlations were observed between anorexia nervosa and body mass index, insulin, glucose, and lipid phenotypes.ConclusionsAnorexia nervosa is a complex heritable phenotype for which this study has uncovered the first genome-wide significant locus. Anorexia nervosa also has large and significant genetic correlations with both psychiatric phenotypes and metabolic traits. The study results encourage a reconceptualization of this frequently lethal disorder as one with both psychiatric and metabolic etiology.

Published
2017

7. 68 Blue monday - association between incidence of STEMI and day of the week

Author

Laffan, Jack, primary, Walsh, Simon, additional, Byrne, Robert, additional, Coburn, Jaimie, additional, McCann, Conor, additional, Crowley, Jim, additional, McKane, Mark, additional, Kearney, Peter, additional, Kennedy, Mark, additional, McCreery, Charles, additional, Kiernan, Tom, additional, Blake, Gavin, additional, Maree, Andrew, additional, and Peace, Aaron, additional

Published
2023
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10. A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae

Author

Crowley, Jim, Leak, Frank W., Jr., Shianna, Kevin V., Tove, Shirley, and Parks, Leo W.

Subjects
Saccharomyces -- Genetic aspects, Bacterial genetics -- Research, Sterols -- Genetic aspects, Gene mutations -- Research, Calcium -- Usage, Biological sciences
Abstract

The wild-type copy of the UPC2 gene, a mutant that can take up sterols aerobically in heme-competent cells of Saccharomyces cerevisiae, was cloned using a differential calcium phenotype. Experiments showed that upc2-1 was hypersensitive to calcium and its allele was semidominant. UPC2 cloning also indicated that it is YDR213W, an open reading frame on chromosome IV. This belonged to a fungal regulatory family containing the Zn(II)2Cys6 binuclear cluster DNA binding domain.

Published
1998

11. Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa

Author

Walton, E, Hibar, D, Yilmaz, Z, Jahanshad, N, Cheung, J, Batury, V-L, Seitz, J, Bulik, CM, Thompson, PM, Ehrlich, Stefan, Hibar, Derrek P, Stein, Jason L, Renteria, Miguel E, Arias-Vasquez, Alejandro, Desrivieres, Sylvane, Jahanshad, Neda, Toro, Roberto, Wittfeld, Katharina, Abramovic, Lucija, Andersson, Micael, Aribisala, Benjamin S, Armstrong, Nicola J, Bernard, Manon, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brown, Andrew A, Chakravarty, M Mallar, Chen, Qiang, Ching, Christopher RK, Cuellar-Partida, Gabriel, Den Braber, Anouk, Giddaluru, Sudheer, Goldman, Aaron L, Grimm, Oliver, Guadalupe, Tulio, Hass, Johanna, Woldehawariat, Girma, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Loohuis, Loes M Olde, Luciano, Michelle, Macare, Christine, Mather, Karen A, Mattheisen, Manuel, Milaneschi, Yuri, Nho, Kwangsik, Papmeyer, Martina, Ramasamy, Adaikalavan, Risacher, Shannon L, Roiz-Santianez, Roberto, Rose, Emma J, Salami, Alireza, Samann, Philipp G, Schmaal, Lianne, Schork, Andrew J, Shin, Jean, Strike, Lachlan T, Teumer, Alexander, van Donkelaar, Marjolein MJ, van Eijk, Kristel R, Walters, Raymond K, Westlye, Lars T, Whelan, Christopher D, Winkler, Anderson M, Zwiers, Marcel P, Alhusaini, Saud, Athanasiu, Lavinia, Hakobjan, Marina MH, Hartberg, Cecilie B, Haukvik, Unn K, Heister, Angelien JGAM, Hohn, David, Kasperaviciute, Dalia, Liewald, David CM, Lopez, Lorna M, Makkinje, Remco RR, Matarin, Mar, Naber, Marlies AM, Mckay, David R, Needham, Margaret, Nugent, Allison C, Putz, Benno, Shen, Li, Sprooten, Emma, Trabzuni, Daniah, van der Marel, Saskia SL, van Hulzen, Kimm JE, Walton, Esther, Wolf, Christiane, Almasy, Laura, Ames, David, Arepalli, Sampath, Assareh, Amelia A, Bastin, Mark E, Brodaty, Henry, Bulayeva, Kazima B, Carless, Melanie A, Cichon, Sven, Corvin, Aiden, Curran, Joanne E, Czisch, Michael, de Zubicaray, Greig I, Dillman, Allissa, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Fedko, Iryna O, Ferrucci, Luigi, Foroud, Tatiana M, Fox, Peter T, Fukunaga, Masaki, Gibbs, J Raphael, Goring, Harald HH, Green, Robert C, Guelfi, Sebastian, Hansell, Narelle K, Hartman, Catharina A, Hegenscheid, Katrin, Heinz, Andreas, Hernandez, Dena G, Heslenfeld, Dirk J, Hoekstra, Pieter J, Holsboer, Florian, Homuth, Georg, Hottenga, Jouke-Jan, Ikeda, Masashi, Jr, Jack Clifford R, Jenkinson, Mark, Johnson, Robert, Kanai, Ryota, Keil, Maria, Jr, Kent Jack W, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Liu, Xinmin, Longo, Dan L, McMahon, Katie L, Meisenzahl, Eva, Melle, Ingrid, Mohnke, Sebastian, Montgomery, Grant W, Mostert, Jeanette C, Muhleisen, Thomas W, Nalls, Michael A, Nichols, Thomas E, Nilsson, Lars G, Nothen, Markus M, Ohi, Kazutaka, Olvera, Rene L, Perez-Iglesias, Rocio, Pike, G Bruce, Potkin, Steven G, Reinvang, Ivar, Reppermund, Simone, Rietschel, Marcella, Romanczuk-Seiferth, Nina, Rosen, Glenn D, Rujescu, Dan, Schnell, Knut, Schofield, Peter R, Smith, Colin, Steen, Vidar M, Sussmann, Jessika E, Thalamuthu, Anbupalam, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Hernandez, Maria C Valdes, van't Ent, Dennis, van der Brug, Marcel, van der Wee, Nic JA, van Tol, Marie-Jose, Veltman, Dick J, Wassink, Thomas H, Westman, Eric, Zielke, Ronald H, Zonderman, Alan B, Ashbrook, David G, Hager, Reinmar, Lu, Lu, McMahon, Francis J, Morris, Derek W, Williams, Robert W, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Cahn, Wiepke, Calhoun, Vince D, Cavalleri, Gianpiero L, Crespo-Facorro, Benedicto, Dale, Anders M, Davies, Gareth E, Delanty, Norman, Depondt, Chantal, Djurovic, Srdjan, Drevets, Wayne C, Espeseth, Thomas, Gollub, Randy L, Ho, Beng-Choon, Hoffmann, Wolfgang, Hosten, Norbert, Kahn, Rene S, Le Hellard, Stephanie, Meyer-Lindenberg, Andreas, Mueller-Myhsok, Bertram, Nauck, Matthias, Nyberg, Lars, Pandolfo, Massimo, Penninx, Brenda WJH, Roffman, Joshua L, Sisodiya, Sanjay M, Smoller, Jordan W, van Bokhoven, Hans, van Haren, Neeltje EM, Volzke, Henry, Walter, Henrik, Weiner, Michael W, Wen, Wei, White, Tonya, Agartz, Ingrid, Andreassen, Ole A, Blangero, John, Boomsma, Dorret I, Brouwer, Rachel M, Cannon, Dara M, Cookson, Mark R, de Geus, Eco JC, Deary, Ian J, Donohoe, Gary, Fernandez, Guillen, Fisher, Simon E, Francks, Clyde, Glahn, David C, Grabe, Hans J, Gruber, Oliver, Hardy, John, Hashimoto, Ryota, Pol, Hilleke E Hulshoff, Jonsson, Erik G, Kloszewska, Iwona, Lovestone, Simon, Mattay, Venkata S, Mecocci, Patrizia, McDonald, Colm, McIntosh, Andrew M, Ophoff, Roel A, Paus, Tomas, Pausova, Zdenka, Ryten, Mina, Sachdev, Perminder S, Saykin, Andrew J, Simmons, Andrew, Singleton, Andrew, Soininen, Hilkka, Wardlaw, Joanna M, Weale, Michael E, Weinberger, Daniel R, Adams, Hieab HH, Launer, Lenore J, Seiler, Stephan, Schmidt, Reinhold, Chauhan, Ganesh, Satizabal, Claudia L, Becker, James T, Yanek, Lisa R, van der Lee, Sven J, Ebling, Maritza, Fischl, Bruce, Longstreth, WT, Greve, Douglas, Schmidt, Helena, Nyquist, Paul, Vinke, Louis N, van Duijn, Cornelia M, Luting, Xue, Mazoyer, Bernard, Bis, Joshua C, Gudnason, Vilmundur, Seshadri, Sudha, Ikram, M Arfan, Martin, Nicholas G, Wright, Margaret J, Schumann, Gunter, Franke, Barbara, Thompson, Paul M, Medland, Sarah E, Duncan, Laramie, Yilmaz, Zeynep, Walters, Raymond, Goldstein, Jackie, Anttila, Verneri, Bulik-Sullivan, Brendan, Ripke, Stephan, Adan, Roger, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole, Aschauer, Harald, Baker, Jessica, Barrett, Jeffrey, Bencko, Vladimir, Bergen, Andrew, Berrettini, Wade, Birgegard, Andreas, Boni, Claudette, Perica, Vesna Boraska, Brandt, Harry, Burghardt, Roland, Carlberg, Laura, Cassina, Matteo, Cichon, Carolyn Cesta Sven, Clementi, Maurizio, Cohen-Woods, Sarah, Coleman, Joni, Cone, Roger, Courtet, Philippe, Crawford, Steven, Crow, Scott, Crowley, Jim, Danner, Unna, Davis, Oliver, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece, Dick, Danielle, Dikeos, Dimitris, Dina, Christian, Ding, Bo, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Egberts, Karin, Escaramis, Georgia, Esko, Tonu, Estivill, Xavier, Favaro, Angela, Fernandez-Aranda, Fernando, Fichter, Manfred, Finan, Chris, Fischer, Krista, Floyd, James, Focker, Manuel, Foretova, Lenka, Forzan, Monica, Fox, Caroline, Franklin, Christopher, Gallinger, Valerie Gaborieau Steven, Gambaro, Giovanni, Gaspar, Helena, Giegling, Ina, Gonidakis, Fragiskos, Gorwood, Philip, Gratacos, Monica, Guillaume, Sebastien, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine, Harrison, Rebecca, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske, Hendriks, Judith, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hilliard, Christopher, Huckins, Laura, Hudson, James, Huemer, Julia, Imgart, Hartmut, Inoko, Hidetoshi, Jamain, Sigrid Jall Stephane, Janout, Vladimir, Jimenez-Murcia, Susana, Johnson, Craig, Jordan, Jenny, Julia, Antonio, Jureus, Anders, Kalsi, Gursharan, Kaplan, Allan, Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andreas, Kas, Martien, Kaye, Walter, Kennedy, Martin, Kennedy, James, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klareskog, Lars, Klump, Kelly, Knudsen, Gun Peggy, Koeleman, Bobby, Koubek, Doris, La Via, Maria, Landen, Mikael, Leboyer, Marion, Levitan, Robert, Li, Dong, Lichtenstein, Paul, Lilenfeld, Lisa, Lissowska, Jolanta, Lundervold, Astri, Magistretti, Pierre, Maj, Mario, Mannik, Katrin, Marsal, Sara, Kaminska, Debora, Martin, Nicholas, Mattingsdal, Morten, McDevitt, Sara, McGuffin, Peter, Merl, Elisabeth, Metspalu, Andres, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, James, Mitchell, Karen, Monteleone, Palmiero, Monteleone, Alessio Maria, Montgomery, Grant, Mortensen, Preben, Munn-Chernoff, Melissa, Mueller, Timo, Nacmias, Benedetta, Navratilova, Marie, Nilsson, Ida, Norring, Claes, Ntalla, Ioanna, Ophoff, Roel, O'Toole, Julie, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Pinto, Richard Parker Dalila, Rabionet, Raquel, Raevuori, Anu, Rajewski, Andrzej, Ramoz, Nicolas, Rayner, N William, Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rybakowski, Filip, Santonastaso, Paolo, Scherag, Andre, Scherer, Stephen, Schmidt, Ulrike, Schork, Nicholas, Schosser, Alexandra, Scott, Laura, Seitz, Jochen, Slachtova, Lenka, Sladek, Robert, Slagboom, P Eline, Slof-Op't Landt, Margarita, Slopien, Agnieszka, Smith, Tosha, Soranzo, Nicole, Sorbi, Sandro, Southam, Lorraine, Steen, Vidar, Strengman, Eric, Strober, Michael, Szatkiewicz, Jin, Szeszenia-Dabrowska, Neonila, Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tschop, Matthias, Tsitsika, Artemis, Tziouvas, Konstantinos, van Elburg, Annemarie, van Furth, Eric, Wade, Tracey, Wagner, Gudrun, Watson, Hunna, Wichmann, H-Erich, Widen, Elisabeth, Woodside, D Blake, Yanovski, Jack, Yao, Shuyang, Zerwas, Stephanie, Zipfel, Stephan, Thornton, Laura, Hinney, Anke, Breen, Gerome, Bulik, Cynthia M, PGC-ED, Grp, ENIGMA Genetics Working, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Kas lab, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, and APH - Mental Health

Subjects
0301 basic medicine, Anorexia Nervosa, Eating Disorders, REWARD CIRCUITRY, Genome-wide association study, ADOLESCENT, PGC-ED, Bioinformatics, Linkage Disequilibrium, 0302 clinical medicine, Anorexia nervosa, Brain structure, Genetic correlation, SCHIZOPHRENIA, ENIGMA Genetics Working Group, 2.1 Biological and endogenous factors, Psychology, Aetiology, Cervell, RISK, ABNORMALITIES, Anorèxia nerviosa, Brain, FUNCTIONAL CONNECTIVITY, Organ Size, Single Nucleotide, Serious Mental Illness, Magnetic Resonance Imaging, 3. Good health, Anorexia, Mental Health, Neurology, Anorexia nervosa (differential diagnoses), Brain size, MENDELIAN RANDOMIZATION, Biomedical Imaging, Cognitive Sciences, RESPONSE-INHIBITION, Neuroscience (miscellaneous), Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Mendelian randomization, Journal Article, Genetics, Humans, Genetic Testing, GENOME-WIDE ASSOCIATION, Polymorphism, POLYMORPHISMS, Genetic association, Neurology & Neurosurgery, Prevention, Human Genome, Neurosciences, Mendelian Randomization Analysis, Genetic architecture, Brain Disorders, 030104 developmental biology, Genetic marker, Case-Control Studies, 030217 neurology & neurosurgery, Genètica, Genome-Wide Association Study
Abstract

Molecular neurobiology 56(7), 5146-5156 (2019). doi:10.1007/s12035-018-1439-4, Published by Humana Press, Totowa, NJ

Published
2019

16. Aerobic isolation of an ERG24 null mutant of Saccharomyces cerevisiae

Author

Crowley, Jim, Smith, Steven J., Leak, Frank W., and Parks, Leo W.

Subjects
Saccharomyces -- Research, Sterols -- Physiological aspects, Microbial mutation -- Physiological aspects, Bacterial growth -- Research, Biological sciences
Abstract

An ERG24 null mutant of Saccharomyces cerevisiae produces ignosterol as the main sterol and is capable of growth on synthetic culture mediums under aerobic conditions. The mutant produces no ergosterol during growth and is unable to grow on rich YPD medium. This indicates that ignosterol is capable of supporting growth of ERG24 null mutant and lack of the ERG24 encoded C-14 sterol reductase is not necessarily lethal. However, ignosterol is not an effective growth medium under certain conditions.

Published
1996

17. New U-Pb geochronology and fossil age control, Earn group near Anvil lake, central Yukon

Author

Cobbett, Rose, Crowley, Jim, Cordey, Fabrice, Henderson, Charles M., Blodgett, Robert, Yukon Geological Survey, Boise State University, Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement [Lyon] (LGL-TPE), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Department of Geosciences, University of Calgary, Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), and CORDEY, Fabrice

Subjects
[SDU] Sciences of the Universe [physics], [SDU]Sciences of the Universe [physics], [SDU.STU] Sciences of the Universe [physics]/Earth Sciences, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences
Abstract

Session T2. New Discoveries in Resolving the Terrane Assembly of Western North American and Northeast Asia; International audience; New geological mapping near Anvil Lake in the west central part of the Tay River map sheet, south-central Yukon, has highlighted unrecognized stratigraphy within, and re-defined the extent of, Devono-Mississippian formations. Previously mapped Cambro-Ordovician rocks have been newly assigned to the Earn Group based on micro- and macro-fossil data and U-Pb geochronology. The lowermost part of the Earn Group in this area is made up of black chert and recessive shale with rare fossiliferous lenses that yield late early to early Middle Devonian macro-fossils. Sitting conformably above these rocks are coarse sandstone and conglomerate interlayered with siltstone and shale and intermediate volcanic rocks. The latter are andesite flows and crystal tuffs both of which have U-Pb ID-TIMS ages that range from 363-365 Ma. The uppermost part of the Earn Group in this area comprises a succession dominated by fine grained, quartz-rich clastic rocks with lesser limestone that contain Upper Devonian to Lower Mississippian conodonts and radiolarians. Our new detailed mapping and age constraints are improving the stratigraphic knowledge of Devono-Mississippian successions and providing the basis for regional correlation and paleogeographic analysis.

Published
2015

20. Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry

Author

Kotseva, Kornelia, De Backer, Guy, De Bacquer, Dirk, Rydén, Lars, Hoes, Arno, Grobbee, Diederick, Maggioni, Aldo, Marques-Vidal, Pedro, Jennings, Catriona, Abreu, Ana, Aguiar, Carlos, Badariene, Jolita, Bruthans, Jan, Castro Conde, Almudena, Cifkova, Renata, Crowley, Jim, Davletov, Kairat, Deckers, Jaap, De Smedt, Delphine, De Sutter, Johan, Dilic, Mirza, Dolzhenko, Marina, Dzerve, Vilnis, Erglis, Andrejs, Fras, Zlatko, Gaita, Dan, Gotcheva, Nina, Heuschmann, Peter, Hasan-Ali, Hosam, Jankowski, Piotr, Lalic, Nebojsa, Lehto, Seppo, Lovic, Dragan, Mancas, Silvia, Mellbin, Linda, Milicic, Davor, Mirrakhimov, Erkin, Oganov, Rafael, Pogosova, Nana, Reiner, Zeljko, Stöerk, Stefan, Tokgözoğlu, Lâle, Tsioufis, Costas, Vulic, Dusko, and Wood, David

Abstract

Aims The aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice.Design A cross-sectional ESC-EORP survey (EUROASPIRE V) at 131 centres in 81 regions in 27 countries.Methods Patients (<80 years old) with verified coronary artery events or interventions were interviewed and examined ≥6 months later.Results A total of 8261 patients (females 26%) were interviewed. Nineteen per cent smoked and 55% of them were persistent smokers, 38% were obese (body mass index ≥30 kg/m2), 59% were centrally obese (waist circumference: men ≥102 cm; women ≥88 cm) while 66% were physically active <30 min 5 times/week. Forty-two per cent had a blood pressure ≥140/90 mmHg (≥140/85 if diabetic), 71% had low-density lipoprotein cholesterol ≥1.8 mmol/L (≥70 mg/dL) and 29% reported having diabetes. Cardioprotective medication was: anti-platelets 93%, beta-blockers 81%, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers 75% and statins 80%.Conclusion A large majority of coronary patients have unhealthy lifestyles in terms of smoking, diet and sedentary behaviour, which adversely impacts major cardiovascular risk factors. A majority did not achieve their blood pressure, low-density lipoprotein cholesterol and glucose targets. Cardiovascular prevention requires modern preventive cardiology programmes delivered by interdisciplinary teams of healthcare professionals addressing all aspects of lifestyle and risk factor management, in order to reduce the risk of recurrent cardiovascular events.

Published
2019
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21. Delay dismay

Author

Crowley, Jim

Subjects
Computers, High technology industry, Telecommunications industry
Abstract

I loved your story 'Frame relay delays create nightmare for two Mass. firms' (www.nw fusion.com, DocFinder: 2423). I am working with three power plants throughout New York. I have two [...]

Published
2001

22. TCT-580 Two-Year Real-World Outcomes in 1014 Patients Treated With the Thin-Strut, Platinum-Chromium, Paclitaxel-Eluting TAXUS Element ® Stent: Results From the TE-PROVE European Registry

Author

Tamburino, Corrado, primary, Crowley, Jim, additional, Calabria, Paolo, additional, Carrié, Didier, additional, berland, jacques, additional, Lalmand, Jacques, additional, Hauptmann, Karl-Eugen, additional, Capodanno, Davide, additional, Underwood, Paul, additional, and Dawkins, Keith D., additional

Published
2014
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26. Understanding and Using the SharePoint 2013 REST Interface.

Author

Crowley, Jim and Kirkham, Ricky

Subjects
GRAPHICAL user interfaces, INTERNET software, JAVASCRIPT programming language, HTML (Document markup language), COMPUTER access control, COMPUTER software
Abstract

The article discusses the use of Representational State Transfer (REST) Interface that opens development of SharePoint 2013 platform to standard languages and Web technologies. It mentions the requirements including JavaScript and Windows application in Hypertext Markup Language (HTML)5, the use of Open Authentication (OAuth) and construction of the RESTful Uniform Resource Locators (URLs). It also notes the use of Cross-Domain JavaScript Library, writing SharePoint and the ChangeQuery object.

Published
2013

27. Some Reform.

Author

Crowley, Jim

Subjects
CIVIL service, PRESIDENTS of the United States
Abstract

A letter to the editor is presented in response to the cover story in the February 6, 1978 issue on U.S. President Jimmy Carter versus the bureaucrats.

Published
1978

28. Readers Report.

Author

VanLucena, Richard, Hoagland, John H., Shurchliff, William A., Crowley, Jim, Erwin Jr., William A., and Conant, T. A.

Subjects
LETTERS to the editor, INCOME gap, WAGES, GENIUS, CORPORATE vice-presidents
Abstract

Several letters to the editor are presented in response to articles in previous issues including "Closing the Gap in Salaries" in the November 4, 1967 issue, "The Wizard of New Rochelle" in the November 4 issue, and "Samoa on Fiji" in the October 21 issue.

Published
1967

31. 500 million years of episodic anorthosite/leucogabbro -- granodiorite/monzogranite (ALG) magmatism in the Archean Yilgarn craton.

Author

Sylvester, Paul, Crowley, Jim, Souders, Kate, and Myers, John

Subjects
*ANORTHOSITE, *MAGMATISM, *CRATONS, *GEOLOGICAL time scales, *GEOCHEMISTRY, *GRANODIORITE
Abstract

The Narryer Gneiss Complex (NGC) of Western Australia is one of largest intact blocks of early-middle Archean rocks (3.7-3.2 Ga) preserved on Earth. New laser ablation-inductively coupled plasma-mass spectrometer (LA-ICP-MS) U-Pb zircon geochronology and whole rock geochemistry of twenty-five NGC orthogneisses suggest that the terrane formed largely from episodic, bimodal anorthosite/leucogabbro-granodiorite/monzogranite (ALG) magmatism. Trondhjemite-tonalite-granodiorite (TTG) and dioritic magmatism, common in many Archean terranes elsewhere, is rare in the NGC. ALG suites represent a newly-defined, distinctive magmatic association for the Archean, similar in some respects to Mesoproterozoic Anorthosite-Mangerite-Charnockite-(Rapakivi) Granite (AMCG) suites. The gneiss samples were collected from north of the Jack Hills and northwest of Mount Dugel. LA-ICP-MS U-Pb zircon ages cluster at 3720 Ma, 3680 Ma, 3620 Ma, 3490 Ma, 3320 Ma, and 3260 Ma. Each of the age populations includes granodiorite/monzogranite gneisses, and all except the two youngest populations consist of anorthosite/leucogabbro gneisses. The granite gneisses have remarkably similar bulk compositions, independent of age: they are all moderately peraluminous (alumina saturation indices of 1.05 to 1.1) potassic granodiorites and monzogranites, quite unlike their more well-known Archean, sodic TTG counterparts. Formation of the ALG magmatic association is not easily reconciled with convergent plate tectonic processes (subduction). Its existence suggests that a major mechanism of mantle heat loss before 3.2 Ga was by episodic, but long-lived, within-plate magmatism in intra-continental rifts or at hot spots. [ABSTRACT FROM AUTHOR]

Published
2008

32. Q & A.

Author

Crowley, Jim

Subjects
BUSINESS communication, CORPORATE directors, FINANCIAL institutions, FINANCIAL services industry
Abstract

This article presents an interview with Jim Crowley, the managing director of national customers group, Pershing Inc. When asked about the changes that have taken place in Pershing's correspondent clearing business, Crowley said that earlier the firm did recordkeeping on behalf of financial institutions but now it does recordkeeping for the end client. Crowley also spoke on different types of trends emerging in the marketplace that are affecting the business.

Published
2006

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