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216 results on '"Cruzado, J. M."'

1. Recovery of dialysis patients with COVID-19: health outcomes 3 months after diagnosis in ERACODA

Author: Hemmelder, M. H., Noordzij, M., Vart, P., Hilbrands, L. B., Jager, K. J., Abrahams, A. C., Arroyo, D., Battaglia, Y., Ekart, R., Mallamaci, F., Malloney, S. -R., Oliveira, J., Rydzewski, A., Sridharan, S., Vogt, L., Duivenvoorden, R., Gansevoort, R. T., Franssen, C. F. M., van der Net, J. B., Essig, M., du Buf-Vereijken, P. W. G., van Ginneken, B., Maas, N., van Jaarsveld, B. C., Bemelman, F. J., Klingenberg-Salahova, F., Heenan-Vos, F., Vervloet, M. G., Nurmohamed, A., Abramowicz, D., Verhofstede, S., Maoujoud, O., Malfait, T., Fialova, J., Melilli, E., Fava, A., Cruzado, J. M., Perez, N. M., Lips, J., Krepel, H., Adilovic, H., Hengst, M., Konings, C. J. A. M., Braconnier, P., Weis, D., Gellert, R., Alferes, D. G., Radulescu, D., Zakharova, E. V., Ambuehl, P. M., Guidotti, R., Walker, A., Lepeytre, F., Rabate, C., Rostoker, G., Marques, S., Azasevac, T., Majstorovic, G. S., Katicic, D., Dam, M. T., Kruger, T., Brzosko, S., Liakopoulos, V., Zanen, A. L., Logtenberg, S. J. J., Fricke, L., Kuryata, O., Slebe, J. J. P., Abd ElHafeez, S., Kemlin, D., van de Wetering, J., Reinders, M. E. J., Hesselink, D. A., van Gestel, J. K., Eiselt, J., Kielberger, L., El-Wakil, H. S., Verhoeven, M. A. M., Logan, I., Canal, C., Facundo, C., Ramos, A. M., Debska-Slizien, A., Veldhuizen, N. M. H., Tigka, E., Polyzou Konsta, M. A., Panagoutsos, S., Postorino, A., Cambareri, F., Matceac, I., Nistor, I., Covic, A., Groeneveld, J. H. M., Jousma, J., Diekmann, F., Oppenheimer, F., Blasco, M., Pereira, T. A., dos Santos Junior, A. C. S., Arias-Cabrales, C., Crespo, M., Llinas-Mallol, L., Buxeda, A., Tarrega, C. B., Redondo-Pachon, D., Arenas Jimenez, M. D., Mendoza-Valderrey, A., Martins, A. C., Mateus, C., Alvila, G., Laranjinha, I., Hofstra, J. M., Siezenga, M. A., Franco, A., Castellano, S., Rodriguez-Ferrero, M. L., Manzanos, S. B., Haridian Sosa Barrios, R., Lemahieu, W., Bartelet, K., Dirim, A. B., Demir, E., Sever, M. S., Turkmen, A., Safak, S., Hollander, D. A. M. J., Kerckhoffs, A., Buttner, S., de Vries, A. P. J., Meziyerh, S., van der Helm, D., Mallat, M., Bouwsma, H., Petruliene, K., Verberk, I., van der Sande, F. M., Christiaans, M. H. L., Mohankumar, N., Luca, M. D., Tuglular, S. Z., Kramer, A., Beerenhout, C., Luik, P. T., Kerschbaum, J., Tiefenthaler, M., Watschinger, B., Adema, A. Y., Stepanov, V. A., Zulkarnaev, A. B., Turkmen, K., Gandolfini, I., Maggiore, U., Fliedner, A., Asberg, A., Mjoen, G., Miyasato, H., de Fijter, C. W. H., Mongera, N., Pini, S., de Biase, C., van de Logt, A. E., Maas, R., Lebedeva, O., Lopez, V., Reichert, L. J. M., Verhave, J., Titov, D., Parshina, E. V., Zanoli, L., Marcantoni, C., van Kempen, G., van Gils-Verrij, L. E. A., Harty, J. C., Meurs, M., Myslak, M., Lentini, P., den Deurwaarder, E., Stendahl, M., Rahimzadeh, H., Schouten, M., Rychlik, I., Cabezas-Reina, C. J., Roca, A. M., Nauta, F., Sahin, I., Goffin, E., Kanaan, N., Labriola, L., Devresse, A., Diaz-Mareque, A., Coca, A., de Arriba, G., Meijers, B. K. I., Naesens, M., Kuypers, D., Desschans, B., Tonnerlier, A., Wissing, K. M., Dedinska, I., Pessolano, G., Malik, S., Dounousi, E., Papachristou, E., Berger, S. P., Meijer, E., Sanders, J. S. F., Ozyilmaz, A., Ponikvar, J. B., Pernat, A. M., Kovac, D., Arnol, M., Molenaar, F. M., van Zuilen, A. D., Meijvis, S. C. A., Dolmans, H., Tantisattamo, E., Esposito, P., Krzesinski, J. -M., Barahira, J. D., Gallieni, M., Martin-Moreno, P. L., Guglielmetti, G., Guzzo, G., Toapanta, N., Soler, M. J., Luik, A. J., van Kuijk, W. H. M., Stikkelbroeck, L. W. H., Hermans, M. M. H., Rimsevicius, L., Righetti, M., Islam, M., Heitink-Ter Braak, N., Nephrology, ACS - Microcirculation, ACS - Diabetes & metabolism, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Clinical sciences, Faculteit Medische Wetenschappen/UMCG, Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Interne Geneeskunde, RS: Carim - V02 Hypertension and target organ damage, Medical Informatics, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, ACS - Pulmonary hypertension & thrombosis, APH - Health Behaviors & Chronic Diseases, and Internal Medicine
Subjects: Male, Outcome Assessment, survival, mental health status, COVID-19 Testing, SDG 3 - Good Health and Well-being, Renal Dialysis, functional health status, Outcome Assessment, Health Care, 80 and over, Humans, KIDNEY-TRANSPLANT, AcademicSubjects/MED00340, Aged, Aged, 80 and over, Transplantation, SARS-CoV-2, MORTALITY, COVID-19, Middle Aged, Health Care, Intensive Care Units, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Nephrology, dialysis, Original Article, Female, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
Abstract: Background Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months after their COVID-19 diagnosis. Methods We analyzed data on dialysis patients diagnosed with COVID-19 from 1 February 2020 to 31 March 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residence and functional and mental health status (estimated by their treating physician) 3 months after COVID-19 diagnosis. Complete follow-up data were available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression. Results In 2449 hemodialysis patients (mean ± SD age 67.5 ± 14.4 years, 62% male), survival probabilities at 3 months after COVID-19 diagnosis were 90% for nonhospitalized patients (n = 1087), 73% for patients admitted to the hospital but not to an intensive care unit (ICU) (n = 1165) and 40% for those admitted to an ICU (n = 197). Patient survival hardly decreased between 28 days and 3 months after COVID-19 diagnosis. At 3 months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (0.8–6.3%) or a nursing home (∼5%). A higher age and frailty score at presentation and ICU admission were associated with worse functional outcome. Conclusions Mortality between 28 days and 3 months after COVID-19 diagnosis was low and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at 3 months after diagnosis.
Published: 2022

2. Clinical triage of patients on kidney replacement therapy presenting with COVID-19: An ERACODA registry analysis

Author: Mitra, S., Jayanti, A., Vart, P., Coca, A., Gallieni, M., Ovrehus, M. A., Midtvedt, K., Abd Elhafeez, S., Gandolfini, I., Buttner, S., Franssen, C. F. M., Hemmelder, M. H., Van Der Net, J. B., Essig, M., Du Buf-Vereijken, P. W. G., Van Ginneken, B., Maas, N., Vogt, L., Van Jaarsveld, B. C., Jager, K. J., Bemelman, F. J., Klingenberg-Salahova, F., Heenan-Vos, F., Vervloet, M. G., Nurmohamed, A., Abramowicz, D., Verhofstede, S., Maoujoud, O., Malfait, T., Fialova, J., Melilli, E., Fava, A., Cruzado, J. M., Perez, N. M., Lips, J., Krepel, H., Adilovic, H., Hengst, M., Rydzewski, A., Gellert, R., Oliveira, J., Alferes, D. G., Zakharova, E. V., Ambuehl, P. M., Walker, A., Winzeler, R., Lepeytre, F., Rabate, C., Rostoker, G., Marques, S., Azasevac, T., Katicic, D., Dam, M. T., Kruger, T., Brzosko, S., Zanen, A. L., Logtenberg, S. J. J., Fricke, L., Slebe, J. J. P., Kemlin, D., Van De Wetering, J., Reinders, M. E. J., Eiselt, J., Kielberger, L., El-Wakil, H. S., Verhoeven, M. A. M., Canal, C., Facundo, C., Ramos, A. M., Debska-Slizien, A., Veldhuizen, N. M. H., Tigka, E., Konsta, M. A. P., Panagoutsos, S., Mallamaci, F., Postorino, A., Cambareri, F., Covic, A., Matceac, I., Nistor, I., Cordos, M., Groeneveld, J. H. M., Jousma, J., Marjolijn Van Buren, Diekmann, F., Tiago Assis Pereira, Santos, A. C. S., Arias-Cabrales, C., Crespo, M., Llinas-Mallol, L., Buxeda, A., Tarrega, C. B., Redondo-Pachon, D., Jimenez, M. D. A., Hofstra, J. M., Franco, A., Arroyo, D., Rodriguez-Ferrero, M. L., Manzanos, S. B., Barrios, R. H. S., Avila, G., Laranjinha, I., Mateus, C., Lemahieu, W., Bartelet, K., Dirim, A. B., Sever, M. S., Demir, E., Safak, S., Turkmen, A., Hollander, D. A. M. J., De Vries, A. P. J., Meziyerh, S., Van Der Helm, D., Mallat, M., Bouwsma, H., Sridharan, S., Petruliene, K., Maloney, S. -R., Verberk, I., Van Der Sande, F. M., Christiaans, M. H. L., Mohankumar, N., Di Luca, M., Tuglular, S. Z., Kramer, A., Beerenhout, C., Luik, P. T., Kerschbaum, J., Tiefenthaler, M., Watschinger, B., Adema, A. Y., Stepanov, V. A., Zulkarnaev, A. B., Turkmen, K., Fliedner, A., Asberg, A., Mjoen, G., Miyasato, H., De Fijter, C. W. H., Mongera, N., Pini, S., De Biase, C., Duivenvoorden, R., Hilbrands, L., Kerckhoffs, A., Van De Logt, A. -E., Maas, R., Lebedeva, O., Lopez, V., Verhave, J., Reichert, L. J. M., Titov, D., Parshina, E. V., Zanoli, L., Marcantoni, C., Van Gils-Verrij, L. E. A., Harty, J. C., Meurs, M., Myslak, M., Battaglia, Y., Lentini, P., Den Deurwaarder, E., Stendahl, M., Rahimzadeh, H., Schouten, M., Rychlik, I., Cabezas-Reina, C. J., Roca, A. M., Nauta, F., Goffin, E., Kanaan, N., Labriola, L., Devresse, A., Diaz-Mareque, A., Meijers, B. K. I., Naesens, M., Kuypers, D., Desschans, B., Tonnelier, A., Wissing, K. M., De Arriba, G., Dedinska, I., Pessolano, G., Maggiore, U., Malik, S., Papachristou, E., Gansevoort, R. T., Noordzij, M., Berger, S. P., Meijer, E., Ozyilmaz, A., Sanders, J. S. F., Ponikvar, J. B., Arnol, M., Pernat, A. M., Kovac, D., Ekart, R., Abrahams, A. C., Molenaar, F. M., Van Zuilen, A. D., Meijvis, S. C. A., Dolmans, H., Tantisattamo, E., Esposito, P., Krzesinski, J. -M., Barahira, J. D., Sabiu, G., Martin-Moreno, P. L., Guglielmetti, G., Guzzo, G., Toapanta, N., Soler, M. J., Luik, A. J., Van Kuijk, W. H. M., Stikkelbroeck, L. W. H., Hermans, M. M. H., Rimsevicius, L., Righetti, M., Islam, M., Braak, N. H. -T., Nephrology, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Interne Geneeskunde, RS: Carim - V02 Hypertension and target organ damage, Groningen Kidney Center (GKC), ACS - Diabetes & metabolism, AII - Inflammatory diseases, AII - Infectious diseases, Internal Medicine, and Clinical sciences
Subjects: kidney, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Pulmonary insufficiency, infectious diseases, Kidney, Second presentation, Interquartile range, Internal medicine, medicine, Humans, Registries, Mortality, AcademicSubjects/MED00340, Dialysis, Aged, Transplantation, second presentation, business.industry, SARS-CoV-2, COVID-19, medicine.disease, mortality, Triage, Hospitalization, Renal Replacement Therapy, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Nephrology, Oxygen Saturation, dialysis, Original Article, Hemodialysis, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], Presentation (obstetrics), business, transplantation
Abstract: Background Patients on kidney replacement therapy (KRT) are at very high risk of coronavirus disease 2019 (COVID-19). The triage pathway for KRT patients presenting to hospitals with varying severity of COVID-19 illness remains ill-defined. We studied the clinical characteristics of patients at initial and subsequent hospital presentations and the impact on patient outcomes. Methods The European Renal Association COVID-19 Database (ERACODA) was analysed for clinical and laboratory features of 1423 KRT patients with COVID-19 either hospitalized or non-hospitalized at initial triage and those re-presenting a second time. Predictors of outcomes (hospitalization, 28-day mortality) were then determined for all those not hospitalized at initial triage. Results Among 1423 KRT patients with COVID-19 [haemodialysis (HD), n = 1017; transplant, n = 406), 25% (n = 355) were not hospitalized at first presentation due to mild illness (30% HD, 13% transplant). Of the non-hospitalized patients, only 10% (n = 36) re-presented a second time, with a 5-day median interval between the two presentations (interquartile range 2–7 days). Patients who re-presented had worsening respiratory symptoms, a decrease in oxygen saturation (97% versus 90%) and an increase in C-reactive protein (26 versus 73 mg/L) and were older (72 vs 63 years) compared with those who did not return a second time. The 28-day mortality between early admission (at first presentation) and deferred admission (at second presentation) was not significantly different (29% versus 25%; P = 0.6). Older age, prior smoking history, higher clinical frailty score and self-reported shortness of breath at first presentation were identified as risk predictors of mortality when re-presenting after discharge at initial triage. Conclusions This study provides evidence that KRT patients with COVID-19 and mild illness can be managed effectively with supported outpatient care and with vigilance of respiratory symptoms, especially in those with risk factors for poor outcomes. Our findings support a risk-stratified clinical approach to admissions and discharges of KRT patients presenting with COVID-19 to aid clinical triage and optimize resource utilization during the ongoing pandemic.
Published: 2021

3. Ischemia—reperfusion injury as a risk factor for late kidney graft failure

Author: Grinyó, J. M., Gil-Vernet, S., Moreso, F., Serón, D., Fulladosa, X., Cruzado, J. M., Riera, L., Anunciada, A. I., Hueso, M., Alsina, J., Touraine, J. L., editor, Traeger, J., editor, Bétuel, H., editor, Dubernard, J. M., editor, Revillard, J. P., editor, and Dupuy, C., editor
Published: 1997
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4. Changes in renal hemodynamics and physiology after normothermic ischemia in animals supplemented with eicosapentaenoic acid

Author: Torras, J., Soto, K., Riera, M., Herrero, I., Cruzado, J. M., Alsina, J., Valles, J., Grinyo, J. M., Mühlbacher, Ferdinand, editor, Gnant, M., editor, Klepetko, W., editor, Längle, F., editor, Laufer, G., editor, Sautner, T., editor, Steininger, R., editor, Wamser, P., editor, and Kootstra, G., editor
Published: 1996
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5. Hepatocyte growth factor gene therapy enhances infiltration of macrophages and may induce kidney repair in db/db mice as a model of diabetes

Author: Flaquer, M., Franquesa, M., Vidal, A., Bolaños, N., Torras, J., Lloberas, N., Herrero-Fresneda, I., Grinyó, J. M., and Cruzado, J. M.
Published: 2012
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6. In vivo therapeutic efficacy of intra-renal CD40 silencing in a model of humoral acute rejection

Author: Ripoll, E, Pluvinet, R, Torras, J, Olivar, R, Vidal, A, Franquesa, M, Cassis, L, Cruzado, J M, Bestard, O, Grinyó, J M, Aran, J M, and Herrero-Fresneda, I
Published: 2011
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7. Sterile Leukocyturia Is Associated With Interstitial Fibrosis and Tubular Atrophy in Kidney Allograft Protocol Biopsies

Author: Coelho, S., Ortíz, F., Gelpi, R., Koskinen, P., Porta, N., Bestard, O., Melilli, E., Taco, O., Torras, J., Honkanen, E., Grinyó, J. M., and Cruzado, J. M.
Published: 2014
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8. Successful Treatment of Chronic HCV Infection Should Not Preclude Kidney Donation to an HCV Negative Recipient

Author: Cruzado, J. M., Gil-Vernet, S., Castellote, J., Bestard, O., Melilli, E., and Grinyó, J. M.
Published: 2013
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9. Direct electrotransfer of hHGF gene into kidney ameliorates ischemic acute renal failure

Author: Franquesa, M, Alperovich, G, Herrero-Fresneda, I, Lloberas, N, Bolaños, N, Fillat, C, Rama, I, Cruzado, J M, Grinyó, J M, and Torras, J
Published: 2005
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10. Cross-Validation of IFN-γ Elispot Assay for Measuring Alloreactive Memory/Effector T Cell Responses in Renal Transplant Recipients

Author: Bestard, O., Crespo, E., Stein, M., Lúcia, M., Roelen, D. L., de Vaal, Y. J., Hernandez-Fuentes, M. P., Chatenoud, L., Wood, K. J., Claas, F. H., Cruzado, J. M., Grinyó, J. M., Volk, H. D., and Reinke, P.
Published: 2013
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11. Pretransplant Immediately Early-1-Specific T Cell Responses Provide Protection for CMV Infection After Kidney Transplantation

Author: Bestard, O., Lucia, M., Crespo, E., Van Liempt, B., Palacio, D., Melilli, E., Torras, J., Llaudó, I., Cerezo, G., Taco, O., Gil-Vernet, S., Grinyó, J. M., and Cruzado, J. M.
Published: 2013
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12. Dendritic cells phenotype fitting under hypoxia or lipopolysaccharide; adenosine 5′-triphosphate-binding cassette transporters far beyond an efflux pump

Author: Lloberas, N., Rama, I., Llaudó, I., Torras, J., Cerezo, G., Cassis, L., Franquesa, M., Merino, A., Benitez-Ribas, D., Cruzado, J. M., Herrero-Fresneda, I., Bestard, O., and Grinyó, J. M.
Published: 2013
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13. Long-Term Results of Biopsy-Guided Selection and Allocation of Kidneys From Older Donors in Older Recipients

Author: Fernández-Lorente, L., Riera, L., Bestard, O., Carrera, M., Gomà, M., Porta, N., Torras, J., Melilli, E., Gil-Vernet, S., Grinyó, J. M., and Cruzado, J. M.
Published: 2012
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14. Successful outcome of ganciclovir-resistant cytomegalovirus infection in organ transplant recipients after conversion to mTOR inhibitors

Author: Sabé, N., González-Costello, J., Rama, I., Niubó, J., Bodro, M., Roca, J., Cruzado, J M., Manito, N., and Carratalà, J.
Published: 2012
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15. Biopsy-Guided Selection and Allocation of Kidneys from Older Donors in Older Recipients.: Abstract# 122

Author: Cruzado, J. M., Fernandez-Lorente, L., Bestard, O., Riera, L., Gumà, M., Torras, J., Melilli, E., Gil-Vernet, S., and Grinyó, J. M.
Published: 2012

16. Intragraft Regulatory T Cells in Protocol Biopsies Retain Foxp3 Demethylation and Are Protective Biomarkers for Kidney Graft Outcome

Author: Bestard, O., Cuñetti, L., Cruzado, J. M., Lucia, M., Valdez, R., Olek, S., Melilli, E., Torras, J., Mast, R., Gomà, M., Franquesa, M., and Grinyó, J. M.
Published: 2011
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17. A HIGH GLOMERULAR FILTRATION RATE (GFR) AND THE USE OF AN ENTERIC-COATED FORMULATION OF MYCOPHENOLIC ACID PREDICT LESS GASTROINTESTINAL COMPLAINTS IN RENAL TRANSPLANT PATIENTS: RO-324

Author: Ortega, F., Sánchez-Fructuoso, A., Cruzado, J. M., Gómez-Alamillo, J. C., Alarcón, A., Pallardó, Ll., Morales, J. M., Oliver, J., and Guinea, G.
Published: 2011

18. INFLUENCE OF VIRAL REPLICATION AT THE TIME OF RENAL TRANSPLANTATION ON THE LONG-TERM OUTCOME OF PATIENTS WITH POSITIVE SEROLOGY FOR HEPATITIS C VIRUS: RO-021

Author: Morales, J. M., Govantes, Gentil M.A., Esforzado, N., Saval, N., González Roncero, F. M., and Cruzado, J. M.
Published: 2011

19. Successful Renal Transplantation in a Patient with Atypical Hemolytic Uremic Syndrome Carrying Mutations in Both Factor I and MCP

Author: Cruzado, J. M., de Córdoba, Rodríguez S., Melilli, E., Bestard, O., Rama, I., Sánchez-Corral, P., López-Trascasa, M., Navarro, I., Torras, J., Gomà, M., and Grinyó, J. M.
Published: 2009
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20. Poster Board #-Session: P92-I Quality of Life and Tolerability of Enteric-Coated Mycophenolate Sodium (EC-MPS) in Renal Transplant Recipients with Gastrointestinal Tract Complaints to Mycophenolate Mofetil (MMF): A Multicenter, Randomized, Open-Label, Controlled Trial.: Abstract# 749

Author: Ortega, F., Sánchez-Fructuoso, A., Cruzado, J. M., Gómez-Alamillo, J. C., Alarcón, A., Pallardó, L. M., Morales, J. M., Oliver, J., and Fuster, E.
Published: 2009

21. Immunephenotype of Glomerular and Interstitial Infiltrating Cells in Protocol Renal Allograft Biopsies and Histological Diagnosis

Author: Moreso, F., Seron, D., OʼValle, F., Ibernon, M., Gomà, M., Hueso, M., Cruzado, J. M., Bestard, O., Duarte, V., del Moral, R. García, and Grinyó, J. M.
Published: 2007

22. Immunosuppression for Dual Kidney Transplantation with Marginal Organs: The Old Is Better Yet

Author: Cruzado, J. M., Bestard, O., Riera, L., Torras, J., Gil-Vernet, S., Serón, D., Rama, I., Moreso, F., Martínez-Castelao, A., and Grinyó, J. M.
Published: 2007

23. Mycophenolate Mofetil and Sirolimus Combination in Renal Transplantation

Author: Grinyó, J. M. and Cruzado, J. M.
Published: 2006

24. Subclinical rejection impairs glomerular adaptation after renal transplantation

Author: Ibernón, M, Gomá, M, Moreso, F, Fulladosa, X, Hueso, M, Cruzado, J M, Torras, J, Bestard, O, Grinyó, J M, and Serón, D
Published: 2006

25. HGF gene therapy attenuates renal allograft scarring by preventing the profibrotic inflammatory-induced mechanisms

Author: Herrero-Fresneda, I, Torras, J, Franquesa, M, Vidal, A, Cruzado, J M, Lloberas, N, Fillat, C, and Grinyó, J M
Published: 2006

26. Subclinical Rejection Associated with Chronic Allograft Nephropathy in Protocol Biopsies as a Risk Factor for Late Graft Loss

Author: Moreso, F., Ibernon, M., Gomà, M., Carrera, M., Fulladosa, X., Hueso, M., Gil-Vernet, S., Cruzado, J. M., Torras, J., Grinyó, J. M., and Serón, D.
Published: 2006

27. EARLY IMMUNOSUPPRESSION WITH RAPAMYCIN AFTER PROLONGED COLD ISCHEMIA MODIFIES THE OUTCOME OF CHRONIC ALLOGRAFT NEPHROPATHY

Author: Fresneda, Herrero, Terras, J., Vidal, A., Lloberas, N, Cruzado, J. M., and Grinyo, J. M.
Published: 2003

28. Effect of a platelet-activating factor (PAF) receptor antagonist on hyperacute xenograft rejection; evaluation in a pig kidney-human blood xenoperfusion model

Author: CRUZADO, J. M., TORRAS, J., RIERA, M., LLOBERAS, N., HERRERO, I., CONDOM, E., MARTORELL, J., ALSINA, J., and GRINYÓ, J. M.
Published: 1998

29. Early Conversion From Calcineurin Inhibitor- to Everolimus-Based Therapy Following Kidney Transplantation: Results of the Randomized ELEVATE Trial

Author: de Fijter, J. W., Holdaas, H., Oyen, O., Sanders, J. -S., Sundar, S., Bemelman, F. J., Sommerer, C., Pascual, J., Avihingsanon, Y., Pongskul, C., Oppenheimer, F., Toselli, L., Russ, G., Wang, Z., Lopez, P., Kochuparampil, J., Cruzado, J. M., van der Giet, M., Gaite, L. E., Lopez, V. F., Maldonado, R., Massari, P., Novoa, P., Palti, G., Chadban, S., Kanellis, J., Masterson, R., Oberbauer, R., Saemann, M., Kuypers, D., Lohmus, A., Cassuto, E., Frimat, L., Lebranchu, Y., Le Meur, Y., Rostaing, L., Hauser, A., Muehlfeld, A., Nashan, B., Suwelack, B., Weithofer, P., Witzke, O., Zeier, M., Apostolou, T., Boletis, I., Gourmenos, D., Jasuja, S., Khullar, D., Ravishankar, M. S., Sharma, R. K., Garosi, G., Rigotti, P., Tisone, G., Todeschini, P., Acevedo, R., Rozentais, R., Juarez, F. J., Mier, G. M., Urrea, M., Machado, D., Nolasco, F., Sampaio, S., Dubanova, A., Lucan, M., Kolsanov, A. V., Medvedev, V. L., Moysyuk, Y. G., Nesterenko, V., Perlin, D. V., Ulyankina, I. V., Zagainov, E., Dalmau, A., Hernandez, D., Millan, S., Avhingsanon, Y., Turkmen, A., Tuncer, M., Yildiz, A., DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, Kuypers, Dirk, AII - Inflammatory diseases, Nephrology, AII - Amsterdam institute for Infection and Immunity, Groningen Kidney Center (GKC), and Groningen Institute for Organ Transplantation (GIOT)
Subjects: Graft Rejection, Male, HLA ANTIBODIES, immunosuppressant, kidney transplantation/nephrology, ELEVATE study, SIROLIMUS, immunosuppression/immune modulation, 030204 cardiovascular system & hematology, 030230 surgery, Pharmacology, Kidney Function Tests, Kidney Failure, 0302 clinical medicine, Postoperative Complications, cardiovascular disease, Risk Factors, Clinical endpoint, Immunology and Allergy, DONOR-SPECIFIC ANTIBODIES, Pharmacology (medical), Chronic, CARDIAC-HYPERTROPHY, Kidney transplantation, calcineurin inhibitor (CNI), clinical research/practice, clinical trial, kidney (allograft) function/dysfunction, mechanistic target of rapamycin: everolimus, Everolimus, Female, Follow-Up Studies, Glomerular Filtration Rate, Graft Survival, Humans, Immunosuppressive Agents, Kidney Failure, Chronic, Kidney Transplantation, Middle Aged, Prognosis, Tacrolimus, RENAL-TRANSPLANTATION, Kidney transplant, ELEVATE study, Certican, Life Sciences & Biomedicine, medicine.drug, medicine.medical_specialty, Certican, Urology, Renal function, Mycophenolic acid, 03 medical and health sciences, LEFT-VENTRICULAR MASS, PRESSURE-OVERLOAD, medicine, Kidney transplant, Transplantation, Science & Technology, business.industry, medicine.disease, Settore MED/18, Calcineurin, RECIPIENTS, MAMMALIAN TARGET, Sirolimus, CYCLOSPORINE, Surgery, business
Abstract: none 24 si In a 24-month, multicenter, open-label, randomized trial, 715 de novo kidney transplant recipients were randomized at 10-14 weeks to convert to everolimus (n = 359) or remain on standard calcineurin inhibitor (CNI) therapy (n = 356; 231 tacrolimus; 125 cyclosporine), all with mycophenolic acid and steroids. The primary endpoint, change in estimated glomerular filtration rate (eGFR) from randomization to month 12, was similar for everolimus versus CNI: mean (standard error) 0.3(1.5) mL/min/1.732 versus -1.5(1.5) mL/min/1.732 (p = 0.116). Biopsy-proven acute rejection (BPAR) at month 12 was more frequent under everolimus versus CNI overall (9.7% vs. 4.8%, p = 0.014) and versus tacrolimus-treated patients (2.6%, p < 0.001) but similar to cyclosporine-treated patients (8.8%, p = 0.755). Reporting on de novo donor-specific antibodies (DSA) was limited but suggested more frequent anti-HLA Class I DSA under everolimus. Change in left ventricular mass index was similar. Discontinuation due to adverse events was more frequent with everolimus (23.6%) versus CNI (8.4%). In conclusion, conversion to everolimus at 10-14 weeks posttransplant was associated with renal function similar to that with standard therapy overall. Rates of BPAR were low in all groups, but lower with tacrolimus than everolimus open de Fijter JW, Holdaas H, Øyen O, Sanders JS, Sundar S, Bemelman FJ, Sommerer C, Pascual J, Avihingsanon Y, Pongskul C, Oppenheimer F, Toselli L, Russ G, Wang Z, Lopez P, Kochuparampil J, Cruzado JM, van der Giet M; ELEVATE Study Group: [...; Guido Garosi; Paolo Rigotti; Giuseppe Tisone; Paola Todeschini; ...] de Fijter JW, Holdaas H, Øyen O, Sanders JS, Sundar S, Bemelman FJ, Sommerer C, Pascual J, Avihingsanon Y, Pongskul C, Oppenheimer F, Toselli L, Russ G, Wang Z, Lopez P, Kochuparampil J, Cruzado JM, van der Giet M; ELEVATE Study Group: [..; Guido Garosi; Paolo Rigotti; Giuseppe Tisone; Paola Todeschini; ..]
Published: 2017

30. Contribution of Population Pharmacokinetics to Dose Optimization of Ganciclovir-Valganciclovir in Solid-Organ Transplant Patients

Author: Padullés, A., primary, Colom, H., additional, Bestard, O., additional, Melilli, E., additional, Sabé, N., additional, Rigo, R., additional, Niubó, J., additional, Torras, J., additional, Lladó, L., additional, Manito, N., additional, Caldés, A., additional, Cruzado, J. M., additional, Grinyó, J. M., additional, and Lloberas, N., additional
Published: 2016
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31. Resultats assolits en xenotrasplantament

Author: Cruzado, J. M.
Published: 2001

32. Tubular ischemia and toxicity

Author: Cantaluppi, V., primary, Medica, D., additional, Figliolini, F., additional, Gatti, S., additional, Bruno, S., additional, Quercia, A. D., additional, Dellepiane, S., additional, Biancone, L., additional, Tetta, C., additional, Camussi, G., additional, Zhou, L., additional, Dai, X., additional, Feng, M., additional, Huang, X., additional, Fu, P., additional, Lan, H. Y., additional, de Ramon, L., additional, Ripoll, E., additional, Luzardo, L., additional, Merino, A., additional, Bolanos, N., additional, Lloberas, N., additional, Cruzado, J. M., additional, Grinyo, J. M., additional, Torras, J., additional, Kaucsar, T., additional, Revesz, C., additional, Godo, M., additional, Racz, Z., additional, Tarszabo, R., additional, Hamar, P., additional, Banki, N. F., additional, Hosszu, A., additional, Antal, Z., additional, Koszegi, S., additional, Wagner, L., additional, Gellai, R., additional, Lenart, L., additional, Vannay, A., additional, Muller, V., additional, Szabo, A. J., additional, Tulassay, T., additional, and Fekete, A., additional
Published: 2013
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33. Diabetes - basic research

Author: Sarkozi, R., primary, Pirklbauer, M., additional, Mayer, G., additional, Schramek, H., additional, Flaquer, M., additional, Franquesa, M., additional, Vidal, A., additional, Bolanos, N., additional, Torras, J., additional, Lloberas, N., additional, Grinyo, J. M., additional, Cruzado, J. M., additional, Chen, K., additional, Zhang, W., additional, Zhang, J., additional, He, Y., additional, Gagnon, L., additional, Geerts, L., additional, Doucet, A., additional, Sarra-Bournet, F., additional, Leduc, M., additional, Abbott, S., additional, Duceppe, J.-S., additional, Zacharie, B., additional, Penney, C., additional, Laurin, P., additional, Grouix, B., additional, Powers, J., additional, Sullivan, T., additional, Miao, Z., additional, Berahovich, R., additional, Ertl, L., additional, Walters, M., additional, Miao, S., additional, Jaen, J., additional, and Schall, T., additional
Published: 2013
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34. Transplantation: clinical studies - A

Author: Yildirim, T., primary, Yilmaz, R., additional, Altindal, M., additional, Turkmen, E., additional, Arici, M., additional, Altun, B., additional, Erdem, Y., additional, Guliyev, O., additional, Erkmen Uyar, M., additional, Tutal, E., additional, Bal, Z., additional, Sezer, S., additional, Bal, U., additional, Say n, B., additional, Erdemir, B., additional, O'Rourke-Potowki, A., additional, Gauge, N., additional, Penny, H., additional, Cronin, A., additional, Frame, S., additional, Goldsmith, D. J., additional, Yagan, J. A., additional, Chandraker, A., additional, Velickovic Radovanovic, R. M., additional, Catic Djordjevic, A., additional, Mitic, B., additional, Stefanovic, N., additional, Cvetkovic, T., additional, Serpieri, N., additional, Grosjean, F., additional, Sileno, G., additional, Torreggiani, M., additional, Esposito, V., additional, Mangione, F., additional, Abelli, M., additional, Castoldi, F., additional, Catucci, D., additional, Esposito, C., additional, Dal Canton, A., additional, Vatazin, A. V., additional, Zulkarnaev, A. B., additional, Borst, C., additional, Liu, Y., additional, Thoning, J., additional, Tepel, M., additional, Libetta, C., additional, Margiotta, E., additional, Borettaz, I., additional, Canevari, M., additional, Martinelli, C., additional, Lainu, E., additional, Meloni, F., additional, Sepe, V., additional, Miguel Costa, R., additional, Vasquez Martul, E., additional, Reboredo, J., additional, Rivera, C., additional, Simonato, F., additional, Tognarelli, G., additional, Daidola, G., additional, Gallo, E., additional, Burdese, M., additional, Cantaluppi, V., additional, Biancone, L., additional, Segoloni, G. P., additional, Priora, M., additional, Messina, M., additional, Tamagnone, M., additional, Linsalata, A., additional, Lavacca, A., additional, Segoloni, G., additional, Zuidema, W., additional, Erdman, R., additional, van de Wetering, J., additional, Dor, F., additional, Roodnat, J., additional, Massey, E., additional, Timmerman, L., additional, IJzermans, J., additional, Weimar, W., additional, Sibley-Allen, C., additional, Hilton, R., additional, Moghul, M., additional, Burnapp, L., additional, Blake, G., additional, Koo, T. Y., additional, Park, J.-S., additional, Park, H. C., additional, Kim, G.-H., additional, Lee, C. H., additional, Oh, I. H., additional, Kang, C. M., additional, Hwang, J. K., additional, Park, S. C., additional, Choi, B. S., additional, Chun, H. J., additional, Kim, J. I., additional, Yang, C. W., additional, Moon, I. S., additional, Van Laecke, S., additional, Van Biesen, W., additional, Nagler, E. V., additional, Taes, Y., additional, Peeters, P., additional, Vanholder, R., additional, Pruthi, R., additional, Ravanan, R., additional, Casula, A., additional, Harber, M., additional, Roderick, P., additional, Fogarty, D., additional, Cho, A., additional, Shin, J.-h., additional, Jang, H. R., additional, Lee, J. E., additional, Huh, W., additional, Kim, D. J. K., additional, Oh, H. Y., additional, Kim, Y.-G., additional, Sancho Calabuig, A., additional, Gavela Martinez, E., additional, Kanter Berga, J., additional, Beltran Catalan, S., additional, Avila Bernabeu, A. I., additional, Pallardo Mateu, L. M., additional, Gonzalez, E., additional, Polanco, N., additional, Molina, M., additional, Gutierrez, E., additional, Garcia Puente, L., additional, Sevillano, A., additional, Morales, E., additional, Praga, M., additional, Andres, A., additional, Banasik, M., additional, Boratynska, M., additional, Koscielska-Kasprzak, K., additional, Bartoszek, D., additional, Myszka, M., additional, Zmonarski, S., additional, Nowakowska, B., additional, Wawrzyniak, E., additional, Halon, A., additional, Chudoba, P., additional, Klinger, M., additional, Rojas-Rivera, J., additional, Morales, J. M., additional, Egido, J., additional, Kopecky, C. M., additional, Haidinger, M., additional, Kaltenecker, C., additional, Antlanger, M., additional, Marsche, G., additional, Holzer, M., additional, Kovarik, J., additional, Werzowa, J., additional, Hecking, M., additional, Saemann, M. D., additional, Kim, J. M., additional, Koh, E. S., additional, Chung, B. H., additional, Kim, Y. S., additional, Krajewska, M., additional, Mazanowska, O., additional, Kaminska, D., additional, Zabinska, M., additional, Malkiewicz, B., additional, Patrzalek, D., additional, Sulowicz, J., additional, Szostek, S., additional, Wojas-Pelc, A., additional, Ignacak, E., additional, Sulowicz, W., additional, Bellizzi, V., additional, Calella, P., additional, Cupisti, A., additional, Capitanini, A., additional, D'Alessandro, C., additional, Giannese, D., additional, Camocardi, A., additional, Conte, G., additional, Barsotti, M., additional, Bilancio, G., additional, Luciani, R., additional, Locsey, L., additional, Seres, I., additional, Kovacs, D., additional, Asztalos, L., additional, Paragh, G., additional, Wohlfahrtova, M., additional, Balaz, P., additional, Rokosny, S., additional, Wohlfahrt, P., additional, Bartonova, A., additional, Viklicky, O., additional, Kers, J., additional, Geskus, R. B., additional, Meijer, L. J., additional, Bemelman, F., additional, ten Berge, I. J. M., additional, Florquin, S., additional, Hwang, J.-C., additional, Jiang, M.-Y., additional, Lu, Y.-H., additional, Weng, S.-F., additional, Testa, A., additional, Porto, G., additional, Sanguedolce, M., additional, Spoto, B., additional, Parlongo, R., additional, Pisano, A., additional, Enia, G., additional, Tripepi, G., additional, Zoccali, C., additional, Mamode, N., additional, Lennerling, A., additional, Citterio, F., additional, Van Assche, K., additional, Sterckx, S., additional, Frunza, M., additional, Jung, H., additional, Pascalev, A., additional, Johnson, R., additional, Loven, C., additional, Soleymanian, T., additional, Keyvani, H., additional, Jazayeri, S. M., additional, Fazeli, Z., additional, Ghamari, S., additional, Mahabadi, M., additional, Chegeni, V., additional, Najafi, I., additional, Ganji, M. R., additional, Meys, K. M. E., additional, Groothoff, J. W., additional, Jager, K., additional, Schaefer, F., additional, Tonshoff, B., additional, Mota, C., additional, Cransberg, K., additional, van Stralen, K., additional, Gurluler, E., additional, Gures, N., additional, Alim, A., additional, Gurkan, A., additional, Cakir, U., additional, Berber, I., additional, Caluwe, R., additional, Nagler, E., additional, Van Vlem, B., additional, Betkowska-Prokop, A., additional, Kuzniewski, M., additional, Krzanowski, M., additional, Masson, I., additional, Flamant, M., additional, Maillard, N., additional, Cavalier, E., additional, Moranne, O., additional, Alamartine, E., additional, Mariat, C., additional, Delanaye, P., additional, Canas Sole, L. L., additional, Iglesias Alvarez, E., additional, Pastor, M. C. M. C., additional, Moreno Flores, F. F., additional, Abujder, V. V., additional, Graterol, F. F., additional, Bonet Sol, J. J., additional, Lauzurica Valdemoros, R. R., additional, Yoshikawa, M., additional, Kitamura, K., additional, Nakai, K., additional, Goto, S., additional, Fujii, H., additional, Ishimura, T., additional, Takeda, M., additional, Fujisawa, M., additional, Nishi, S., additional, Prasad, N., additional, Gurjer, D., additional, Bhadauria, D., additional, Gupta, A., additional, Sharma, R., additional, Kaul, A., additional, Cybulla, M., additional, West, M., additional, Nicholls, K., additional, Torras, J., additional, Sunder-Plassmann, G., additional, Feriozzi, S., additional, Lo, S., additional, Wong, P. Y. H., additional, Ip, D., additional, Wong, C. K., additional, Chow, V. C. C., additional, Mo, S. K. L., additional, Molnar, M., additional, Ujszaszi, A., additional, Czira, M. E., additional, Novak, M., additional, Mucsi, I., additional, Cruzado, J. M., additional, Coelho, S., additional, Porta, N., additional, Bestard, O., additional, Melilli, E., additional, Taco, O., additional, Rivas, I., additional, Grinyo, J., additional, Pouteau, L.-M., additional, N'Guyen, J.-M., additional, Hami, A., additional, Hourmant, M., additional, Ghahramani, N., additional, Karparvar, Z., additional, Shadrou, S., additional, Ghahramani, M., additional, Fauvel, J. P., additional, Hadj-Aissa, A., additional, Buron, F., additional, Morelon, E., additional, Ducher, M., additional, Heine, C., additional, Glander, P., additional, Neumayer, H.-H., additional, Budde, K., additional, Liefeldt, L., additional, Montero, N., additional, Webster, A. C., additional, Royuela, A., additional, Zamora, J., additional, Crespo, M., additional, Pascual, J., additional, Adema, A. Y., additional, van Dorp, W. T. H., additional, Mallat, M. J. K., additional, de Fijter, H. W., additional, Hong, Y. A., additional, Park, C. W., additional, Kim, Y.-S., additional, Suleymanlar, G., additional, Uzundurukan, Z., additional, Kapuagas , A., additional, Sencan, I., additional, Akdag, R., additional, Torio, A., additional, Mas, V., additional, Perez-Saez, M. J., additional, Mir, M., additional, Faura, A., additional, Montes-Ares, O., additional, Checa, M. D., additional, Sawinski, D., additional, Trofe-Clark, J., additional, Sparkes, T., additional, Patel, P., additional, Goral, S., additional, Bloom, R., additional, Kim, H. J., additional, Park, S. J., additional, Kim, T. H., additional, Kim, Y. W., additional, Kim, Y. H., additional, Kang, S. W., additional, Abdel Halim, M., additional, Gheith, O., additional, Al-Otaibi, T., additional, Mosaad, A., additional, Awadeen, W., additional, Said, T., additional, Nair, P., additional, and Nampoory, M. R. N., additional
Published: 2013
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35. Early Converison of Calcineurin Inhibitor to Everolimus in De Novo Renal Transplant Recipients and Its Impact on Cardiovascular Parameters: The ELEVATE Study Design

Author: van der Giet, M., primary, de Fijter, J. W., additional, Holdaas, H., additional, Legendre, C., additional, Neumayer, H. H., additional, Machein, U., additional, Junge, G., additional, and Cruzado, J. M., additional
Published: 2012
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36. Embolization of a Failed Renal Allograft Is Associated with Higher Allosensitization and Worse Graft Outcome in Subsequent Kidney Transplants

Author: Draibe, J. B., primary, Gelpi, R., additional, Bestard, O., additional, Cruzado, J. M., additional, Melilli, E., additional, Barranco, R., additional, and Grinyo, J., additional
Published: 2012
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37. Broad spectrum of Fabry disease manifestation in an extended Spanish family with a new deletion in the GLA gene

Author: Lukas, J., primary, Torras, J., additional, Navarro, I., additional, Giese, A.-K., additional, Bottcher, T., additional, Mascher, H., additional, Lackner, K. J., additional, Fauler, G., additional, Paschke, E., additional, Cruzado, J. M., additional, Dudesek, A., additional, Wittstock, M., additional, Meyer, W., additional, and Rolfs, A., additional
Published: 2012
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38. Autoimmune systemic diseases

Author: Ripoll, E., primary, Ripoll, E., additional, Goma, M., additional, Bolanos, N., additional, Herrero, I., additional, Bestard, O., additional, Cruzado, J. M., additional, Grinyo, J. M., additional, Torras, J., additional, Venot, M., additional, Nochy, D., additional, Caudwell, V., additional, Jacquot, C., additional, Hill, G., additional, Piette, J.-C., additional, Daugas, E., additional, Wilde, B., additional, Thewissen, M., additional, Van Paassen, P., additional, Hilhorst, M., additional, Damoiseaux, J., additional, Witzke, O., additional, Cohen Tervaert, J. W., additional, Chen, N., additional, LI, X., additional, Zhang, W., additional, Shen, P., additional, Yu, H., additional, Chen, Y., additional, Ren, H., additional, Ni, L., additional, Lebas, C., additional, Guillevin, L., additional, Berezne, A., additional, Seror, R., additional, Teixeira, L., additional, Pourrat, J., additional, Mahr, A., additional, Hachulla, E., additional, Agard, C., additional, Cabane, J., additional, Vanhille, P., additional, Harle, J.-R., additional, Deleveaux, I., additional, and Mouthon, L., additional
Published: 2012
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39. Multivariate analysis of prognostic factors in renal transplantation

Author: Francesc Moreso, Gallen, M., Garcia-Osuna, R., Torras, J., Gil-Vernet, S., Castelao, A. M., Seron, D., Cruzado, J. M., Alsina, J., and Grinyo, J. M.
Subjects: Adult, Male, Time Factors, Histocompatibility Testing, Graft Survival, Prognosis, Kidney Transplantation, Actuarial Analysis, Predictive Value of Tests, Multivariate Analysis, Humans, Transplantation, Homologous, Female, Immunosuppressive Agents, Follow-Up Studies, Proportional Hazards Models, Retrospective Studies
Published: 1995

40. Early Conversion From Calcineurin Inhibitor‐ to Everolimus‐Based Therapy Following Kidney Transplantation: Results of the Randomized ELEVATETrial

Author: Fijter, J. W., Holdaas, H., Øyen, O., Sanders, J.‐S., Sundar, S., Bemelman, F. J., Sommerer, C., Pascual, J., Avihingsanon, Y., Pongskul, C., Oppenheimer, F., Toselli, L., Russ, G., Wang, Z., Lopez, P., Kochuparampil, J., Cruzado, J. M., Giet, M., Gaite, Luis E, Lopez, Vicente F, Maldonado, Rafael, Massari, Pablo, Novoa, Pablo, Palti, Gustavo, Chadban, Steve, Kanellis, John, Masterson, Rosemary, Oberbauer, Rainer, Saemann, Marcus, Kuypers, Dirk, Lohmus, Alexsander, Cassuto, Elisabeth, Frimat, Luc, Lebranchu, Yvon, Meur, Yannick, Rostaing, Lionel, Hauser, A, Muehlfeld, Anja, Nashan, Bjorn, Suwelack, Barbara, Weithofer, Peter, Witzke, Oliver, Zeier, Martin, Apostolou, Th., Boletis, Ioannis, Gourmenos, Dimitros, Jasuja, Sanjiv, Khullar, Dinesh, Ravishankar, Machiraju Sai, Sharma, R K, Garosi, Guido, Rigotti, Paolo, Tisone, Giuseppe, Todeschini, Paola, Acevedo, Reyes, Rozentais, Rafalis, Juarez, Federico J, Mier, Gustavo Martinez, Urrea, Mancilla, Machado, Dominigos, Nolasco, Fernando, Sampaio, Susana, Dubanova, A, Lucan, Mihai, Kolsanov, Alexander V, Medvedev, Vladimir L, Moysyuk, Yan G, Nesterenko, V, Perlin, Dmitry V, Ulyankina, Irina V, Zagainov, E, Dalmau, Alex, Hernandez, Domingo, Millan, San, Avhingsanon, Yingyos, Turkmen, Aydin, Tuncer, Murat, and Yildiz, Alaattin
Abstract: In a 24‐month, multicenter, open‐label, randomized trial, 715 de novokidney transplant recipients were randomized at 10–14 weeks to convert to everolimus (n = 359) or remain on standard calcineurin inhibitor (CNI) therapy (n = 356; 231 tacrolimus; 125 cyclosporine), all with mycophenolic acid and steroids. The primary endpoint, change in estimated glomerular filtration rate (eGFR) from randomization to month 12, was similar for everolimus versus CNI: mean (standard error) 0.3(1.5) mL/min/1.732versus −1.5(1.5) mL/min/1.732(p = 0.116). Biopsy‐proven acute rejection (BPAR) at month 12 was more frequent under everolimus versus CNIoverall (9.7% vs. 4.8%, p = 0.014) and versus tacrolimus‐treated patients (2.6%, p < 0.001) but similar to cyclosporine‐treated patients (8.8%, p = 0.755). Reporting on de novodonor‐specific antibodies (DSA) was limited but suggested more frequent anti‐HLAClass I DSAunder everolimus. Change in left ventricular mass index was similar. Discontinuation due to adverse events was more frequent with everolimus (23.6%) versus CNI(8.4%). In conclusion, conversion to everolimus at 10–14 weeks posttransplant was associated with renal function similar to that with standard therapy overall. Rates of BPARwere low in all groups, but lower with tacrolimus than everolimus. In a multicenter, open‐label, randomized trial of de novokidney transplant recipients, conversion to everolimus at 10–14 weeks posttransplant is associated with similar renal function as in patients who continue to standard tacrolimus or cyclosporine therapy, with low rates of biopsy‐proven acute rejection in all groups, but lower rates with tacrolimus than everolimus.
Published: 2017
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41. IgA nephropathy recurs early in the graft when assessed by protocol biopsy

Author: Ortiz, F., primary, Gelpi, R., additional, Koskinen, P., additional, Manonelles, A., additional, Raisanen-Sokolowski, A., additional, Carrera, M., additional, Honkanen, E., additional, Grinyo, J. M., additional, and Cruzado, J. M., additional
Published: 2011
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42. Clinical nephrology / Glomerulonephritis

Author: Plaisier, E., primary, Terrier, B., additional, Karras, A., additional, Lacraz, A., additional, Marie, I., additional, Kahn, J.-E., additional, Le Guenno, G., additional, Benarous, L., additional, Hermine, O., additional, Diot, E., additional, Saadoun, D., additional, Cacoub, P., additional, Casian, A., additional, Walsh, M., additional, Berden, A., additional, Jayne, D., additional, Zwerina, J., additional, Bach, C., additional, Martorana, D., additional, Jatzwauk, M., additional, Hegasy, G., additional, Moosig, F., additional, Bremer, J., additional, Wieczorek, S., additional, Moschen, A., additional, Tilg, H., additional, Neumann, T., additional, Spriewald, B., additional, Schett, G., additional, Vaglio, A., additional, Appel, G., additional, Dooley, M. A., additional, Ginzler, E., additional, Isenberg, D., additional, Wofsy, D., additional, Solomons, N., additional, Lisk, L., additional, Cruzado, J. M., additional, Poveda, R., additional, Ibernon, M., additional, Diaz, M., additional, Fulladosa, X., additional, Carrera, M., additional, Torras, J., additional, Bestard, O., additional, Navarro, I., additional, Ballarin, J., additional, Romero, R., additional, and Grinyo, J. M., additional
Published: 2011
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43. Low-dose sirolimus combined with angiotensin-converting enzyme inhibitor and statin stabilizes renal function and reduces glomerular proliferation in poor prognosis IgA nephropathy

Author: Cruzado, J. M., primary, Poveda, R., additional, Ibernon, M., additional, Diaz, M., additional, Fulladosa, X., additional, Carrera, M., additional, Torras, J., additional, Bestard, O., additional, Navarro, I., additional, Ballarin, J., additional, Romero, R., additional, and Grinyo, J. M., additional
Published: 2011
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44. Epidemiology, clinical features and outcomes of pneumonia in patients with chronic kidney disease

Author: Viasus, D., primary, Garcia-Vidal, C., additional, Cruzado, J. M., additional, Adamuz, J., additional, Verdaguer, R., additional, Manresa, F., additional, Dorca, J., additional, Gudiol, F., additional, and Carratala, J., additional
Published: 2011
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45. CELL THERAPY USING MSCS AND BMDCS IN RAT KIDNEY TRANSPLANTATION

Author: Franquesa, M., primary, Flaquer, M., additional, Cruzado, J. M., additional, Torras, J., additional, Grinyo, J., additional, and Herrero-Fresneda, I., additional
Published: 2010
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46. AN ENTERIC-COATED FORMULATION OF MYCOPHENOLIC ACID REDUCES THE RISK OF SUFFERING GASTROINTESTINAL COMPLICATIONS REGARDLESS OF DOSE IN RENAL TRANSPLANT PATIENTS

Author: Ortega, F., primary, S´nchez-Fructuoso, A., additional, Cruzado, J. M., additional, Gómez-Alamillo, J. C., additional, Alarcón, A., additional, Pallardó, L., additional, Morales, J. M., additional, Oliver, J., additional, and Mora, S., additional
Published: 2010
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47. Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?

Author: Torras, J., primary, Herrero-Fresneda, I., additional, Gulias, O., additional, Flaquer, M., additional, Vidal, A., additional, Cruzado, J. M., additional, Lloberas, N., additional, Franquesa, M.{m. d.}l., additional, and Grinyo, J. M., additional
Published: 2009
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48. Renal involvement as the first manifestation of hypereosinophilic syndrome: a case report

Author: Navarro, I., primary, Torras, J., additional, Goma, M., additional, Cruzado, J. M., additional, and Grinyo, J. M., additional
Published: 2009
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49. POLYMORPHISMS OF THE MDR1 GENE IN RENAL TRANSPLANT RECIPIENTS AFFECT THE PGP ACTIVITY. RESULTS OF THE PHARMACOGENETIC SUBSTUDY WITHIN THE SYMPHONY STUDY.

Author: Lloberas, N, primary, Llaudó, I, additional, Torras, J, additional, Caldes, A, additional, Cruzado, J M., additional, Oppenheimer, F, additional, Sanchez-Plumed, J, additional, Gentil, M A., additional, Ekberg, H, additional, and Grinyó, J M., additional
Published: 2008
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50. Different renal toxicity profiles in the association of cyclosporine and tacrolimus with sirolimus in rats

Author: Lloberas, N., primary, Torras, J., additional, Alperovich, G., additional, Cruzado, J. M., additional, Gimenez-Bonafe, P., additional, Herrero-Fresneda, I., additional, Franquesa, M.{m. d.}l., additional, Rama, I., additional, and Grinyo, J. M., additional
Published: 2008
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