1. Classification of colorectal primer carcinoma from normal colon with mid-infrared spectra
- Author
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Borkovits, B., Kontsek, E., Pesti, A., Gordon, P., Gergely, S., Csabai, I., Kiss, A., and Pollner, P.
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Quantitative Biology - Tissues and Organs - Abstract
In this project, we used formalin-fixed paraffin-embedded (FFPE) tissue samples to measure thousands of spectra per tissue core with Fourier transform mid-infrared spectroscopy using an FT-IR imaging system. These cores varied between normal colon (NC) and colorectal primer carcinoma (CRC) tissues. We created a database to manage all the multivariate data obtained from the measurements. Then, we applied classifier algorithms to identify the tissue based on its yielded spectra. For classification, we used the random forest, a support vector machine, XGBoost, and linear discriminant analysis methods, as well as three deep neural networks. We compared two data manipulation techniques using these models and then applied filtering. In the end, we compared model performances via the sum of ranking differences (SRD)., Comment: 15 pages, 5 figures, 4 tables, Conferentia Chemometrica 2023 special edition, for the original digital location, see https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/cem.3542 , digital biblio info: (2024) e3542
- Published
- 2024
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