Search

Your search keyword '"Csepregi, Janka Zsófia"' showing total 13 results
Start Over Author "Csepregi, Janka Zsófia"
13 results on '"Csepregi, Janka Zsófia"'

2. Reply to 'Neutrophils are not required for resolution of acute gouty arthritis in mice'

Author

Reinwald, Christiane, Schauer, Christine, Csepregi, Janka Zsófia, Kienhöfer, Deborah, Weidner, Daniela, Malissen, Marie, Mocsai, Attila, Schett, Georg, Herrmann, Martin, and Hoffmann, Markus

Subjects
Gout -- Development and progression -- Care and treatment, Immune response -- Observations, Biological sciences, Health
Abstract

Author(s): Christiane Reinwald [1]; Christine Schauer [1]; Janka Zsófia Csepregi [2]; Deborah Kienhöfer [1]; Daniela Weidner [1]; Marie Malissen [3]; Attila Mocsai [2, 4]; Georg Schett [1]; Martin Herrmann [1]; [...]

Published
2016
Full Text
View/download PDF

5. Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form

Author

Csepregi, Janka Zsófia, primary, Orosz, Anita, additional, Zajta, Erik, additional, Kása, Orsolya, additional, Németh, Tamás, additional, Simon, Edina, additional, Fodor, Szabina, additional, Csonka, Katalin, additional, Barátki, Balázs L., additional, Kövesdi, Dorottya, additional, He, You-Wen, additional, Gácser, Attila, additional, and Mócsai, Attila, additional

Published
2018
Full Text
View/download PDF

6. Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps

Author

Kienhöfer, Deborah, primary, Hahn, Jonas, additional, Stoof, Julia, additional, Csepregi, Janka Zsófia, additional, Reinwald, Christiane, additional, Urbonaviciute, Vilma, additional, Johnsson, Caroline, additional, Maueröder, Christian, additional, Podolska, Malgorzata J., additional, Biermann, Mona H., additional, Leppkes, Moritz, additional, Harrer, Thomas, additional, Hultqvist, Malin, additional, Olofsson, Peter, additional, Munoz, Luis E., additional, Mocsai, Attila, additional, Herrmann, Martin, additional, Schett, Georg, additional, Holmdahl, Rikard, additional, and Hoffmann, Markus H., additional

Published
2017
Full Text
View/download PDF

8. Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse

Author

Horváth, Ádám, primary, Menghis, Awt, additional, Botz, Bálint, additional, Borbély, Éva, additional, Kemény, Ágnes, additional, Tékus, Valéria, additional, Csepregi, Janka Zsófia, additional, Mócsai, Attila, additional, Juhász, Tamás, additional, Zákány, Róza, additional, Bogdán, Dóra, additional, Mátyus, Péter, additional, Keeble, Julie, additional, Pintér, Erika, additional, and Helyes, Zsuzsanna, additional

Published
2017
Full Text
View/download PDF

9. Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form.

Author

Mócsai, Attila, Csepregi, Janka Zsófia, Orosz, Anita, Kása, Orsolya, Németh, Tamás, Simon, Edina, Zajta, Erik, Csonka, Katalin, Gácser, Attila, Fodor, Szabina, Barátki, Balázs L., Kövesdi, Dorottya, and You-Wen He

Abstract

Mouse strains with specific deficiency of given hematopoietic lineages provide invaluable tools for understanding blood cell function in health and disease. Whereas neutrophils are dominant leukocytes in humans and mice, there are no widely useful genetic models of neutrophil deficiency in mice. In this study, we show that myeloid-specific deletion of the Mcl-1 antiapoptotic protein in Lyz2Cre/Cre Mcl1flox/flox (Mcl1ΔMyelo) mice leads to dramatic reduction of circulating and tissue neutrophil counts without affecting circulating lymphocyte, monocyte, or eosinophil numbers. Surprisingly, Mcl1ΔMyelo mice appeared normally, and their survival was mostly normal both under specific pathogen-free and conventional housing conditions. Mcl1ΔMyelo mice were also able to breed in homozygous form, making them highly useful for in vivo experimental studies. The functional relevance of neutropenia was confirmed by the complete protection of Mcl1ΔMyelo mice from arthritis development in the K/B3N serumtransfer model and from skin inflammation in an autoantibody-induced mouse model of epidermolysis bullosa acquisita. Mcl1ΔMyelo mice were also highly susceptible to systemic Staphylococcus aureus or Candida albicans infection, due to defective clearance of the invading pathogens. Although neutrophil-specific deletion of Mcl-1 in MRP8-CreMcl1flox/flox (Mcl1DPMN) mice also led to severe neutropenia, those mice showed an overt wasting phenotype and strongly reduced survival and breeding, limiting their use as an experimental model of neutrophil deficiency. Taken together, our results with the Mcl1ΔMyelo mice indicate that severe neutropenia does not abrogate the viability and fertility of mice, and they provide a useful genetic mouse model for the analysis of the role of neutrophils in health and disease. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

10. ROS ameriolates the clinical course of murine lupus

Author

Hahn, Jonas, primary, Kienhöfer, Deborah, additional, Stoof, Julia, additional, Csepregi, Janka Zsófia, additional, Reinwald, Christiane, additional, Maueröder, Christian, additional, Urbonaviciute, Vilma, additional, Munoz, Luis E, additional, Hultqvist, Malin, additional, Podolska, Malgorzata J, additional, Biermann, Mona H., additional, Leppkes, Moritz, additional, Herrmann, Martin, additional, Harrer, Thomas, additional, Mocsai, Attila, additional, Holmdahl, Rikard, additional, Schett, Georg, additional, and Hoffmann, Markus, additional

Published
2016
Full Text
View/download PDF

11. P-66 - ROS is the boss

Author

Hahn, Jonas, Kienhöfer, Deborah, Stoof, Julia, Csepregi, Janka Zsofia, Reinwald, Christiane, Maueröder, Chrisitan, Urbonaviciute, Vilma, Munoz, Luis E, Hultqvist, Malin, Podolska, Malgorzata J, Biermann, Mona H, Leppkes, Moritz, Herrmann, Martin, Harrer, Thomas, Mocsai, Attila, Holmdahl, Rikard, Schett, Georg, and Hoffmann, Markus

Published
2018
Full Text
View/download PDF

13. P-48 - ROS ameriolates the clinical course of murine lupus.

Author

Hahn, Jonas, Kienhöfer, Deborah, Stoof, Julia, Csepregi, Janka Zsófia, Reinwald, Christiane, Maueröder, Christian, Urbonaviciute, Vilma, Munoz, Luis E, Hultqvist, Malin, Podolska, Malgorzata J, Biermann, Mona H., Leppkes, Moritz, Herrmann, Martin, Harrer, Thomas, Mocsai, Attila, Holmdahl, Rikard, Schett, Georg, and Hoffmann, Markus

Subjects
*SYSTEMIC lupus erythematosus treatment, *OXYGEN therapy, *OXIDATIVE stress, *AUTOIMMUNITY, *PHAGOCYTOSIS, *LABORATORY mice
Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results