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4. A multi-centre peptidomics investigation of food digesta: current state of the art in mass spectrometry analysis and data visualisation

Author

Portmann, Reto, Jiménez-Barrios, Pablo, Jardin, Julien, Abbühl, Lychou, Barile, Daniela, Danielsen, Marianne, Huang, Yu-Ping, Dalsgaard, Trine Kastrup, Miralles, Beatriz, Briard-Bion, Valérie, Cattaneo, Stefano, Chambon, Christophe, Cudennec, Benoit, De Noni, Ivano, Deracinois, Barbara, Dupont, Didier, Duval, Angéline, Flahaut, Christophe, López-Nicolás, Rubén, Nehir El, Sedef, Pica, Valentina, Santé-Lhoutellier, Véronique, Stuknytė, Milda, Theron, Laetitia, Sayd, Thierry, Recio, Isidra, and Egger, Lotti

Published
2023
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9. A Specific Collagen Hydrolysate Improves Postprandial Glucose Tolerance in Normoglycemic and Prediabetic Mice and in a First Proof of Concept Study in Healthy, Normoglycemic and Prediabetic Humans.

Author

Grasset, Estelle, Briand, François, Virgilio, Nicolina, Schön, Christiane, Wilhelm, Manfred, Cudennec, Benoit, Ravallec, Rozenn, Aboubacar, Hairati, Vleminckx, Sara, Prawitt, Janne, Sulpice, Thierry, and Gevaert, Elien

Subjects
BLOOD sugar, GASTRIC emptying, DIETARY supplements, PEPTIDES, PROOF of concept, INSULIN
Abstract

In response to nutrients, intestinal L‐ and K‐cells naturally secrete glucagon‐like peptide 1 (GLP‐1). GLP‐1 regulates postprandial blood glucose by increasing insulin secretion, slowing down gastric emptying and inducing satiety. A selection of specifically developed collagen hydrolysates was screened for their ability to enhance natural GLP‐1 production in vitro. The best performing hydrolysate, H80 (Nextida GC), was orally administered at different doses to lean, normoglycemic mice and overweight, prediabetic mice. Lean mice were acutely challenged 45 min before an oral glucose load. While daily supplemented for 6 weeks, prediabetic mice were acutely challenged at day 21 and 34. Oral glucose tolerance, plasma insulin and GLP‐1 levels were assessed, and a gastric emptying assay performed in prediabetic mice. H80 significantly lowered the blood glucose response in lean and prediabetic mice, at a 4 g/kg dose (−25% and −36%, respectively), compared to vehicle. In chronically supplemented, prediabetic mice, acute H80 administration slowed down gastric emptying (−60%) after 21 days and increased plasma insulin (+166%) after 35 days of supplementation. H80 increased plasma active GLP‐1 in lean (+217%) and prediabetic (+860%) mice. Overall, the data indicate that the specific collagen hydrolysate, H80, has significant GLP‐1‐mediated effects on oral glucose tolerance in lean and prediabetic mice. Furthermore, effects on postprandial glucose tolerance were evaluated in a small, human, proof of concept study. H80 reduced the postprandial glucose response at a 5 g dose in healthy, normoglycemic and prediabetic participants. Oral supplementation with H80 might thus be a promising strategy to maintain normal glucose tolerance. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Metabolomic Monitoring of Chicory During in Vitro Gastrointestinal Digestion and Correlation with Bioactive Properties

Author

Pouille, Céline L., primary, Dugardin, Camille, additional, Behra, Josette, additional, Tourret, Melissa, additional, Molinié, Roland, additional, Fontaine, Jean-Xavier, additional, Mathiron, David, additional, Palaric, Cécile, additional, Gagneul, David, additional, Ravallec, Rozenn, additional, Rambaud, Caroline, additional, Hilbert, Jean-Louis, additional, LUCAU-DANILA, Anca, additional, and Cudennec, Benoit, additional

Published
2024
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30. A multi-centre peptidomics investigation of food digesta: current state of the art in mass spectrometry analysis and data visualisation

Author

Department of Agriculture (US), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ege University, European Commission, Agence Nationale de la Recherche (France), Aarhus University Research Foundation, Portmann, Reto, Jiménez-Barrios, Pablo, Jardin, Julien, Abbühl, Lychou, Barile, Daniela, Danielsen, Marianne, Huang, Yu-Ping, Kastrup Dalsgaard, Trine, Miralles, Beatriz, Briard-Bion, Valérie, Cattaneo, Stefano, Chambon, Christophe, Cudennec, Benoit, De Noni, Ivano, Deracinois, Barbara, Dupont, Didier, Duval, Angéline, Flahaut, Christophe, López-Nicolás, Rubén, Nehir El, Sedef, Pica, Valentina, Santé-Lhoutelier, Véronique, Stuknytė, Milda, Théron, Laëtitia, Sayd, Thierry, Recio, Isidra, Egger, Lotti, Department of Agriculture (US), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ege University, European Commission, Agence Nationale de la Recherche (France), Aarhus University Research Foundation, Portmann, Reto, Jiménez-Barrios, Pablo, Jardin, Julien, Abbühl, Lychou, Barile, Daniela, Danielsen, Marianne, Huang, Yu-Ping, Kastrup Dalsgaard, Trine, Miralles, Beatriz, Briard-Bion, Valérie, Cattaneo, Stefano, Chambon, Christophe, Cudennec, Benoit, De Noni, Ivano, Deracinois, Barbara, Dupont, Didier, Duval, Angéline, Flahaut, Christophe, López-Nicolás, Rubén, Nehir El, Sedef, Pica, Valentina, Santé-Lhoutelier, Véronique, Stuknytė, Milda, Théron, Laëtitia, Sayd, Thierry, Recio, Isidra, and Egger, Lotti

Abstract

Mass spectrometry has become the technique of choice for the assessment of a high variety of molecules in complex food matrices. It is best suited for monitoring the evolution of digestive processes in vivo and in vitro. However, considering the variety of equipment available in different laboratories and the diversity of sample preparation methods, instrumental settings for data acquisition, statistical evaluations, and interpretations of results, it is difficult to predict a priori the ideal parameters for optimal results. The present work addressed this uncertainty by executing an inter-laboratory study with samples collected during in vitro digestion and presenting an overview of the state-of-the-art mass spectrometry applications and analytical capabilities available for studying food digestion. Three representative high-protein foods – skim milk powder (SMP), cooked chicken breast and tofu – were digested according to the static INFOGEST protocol with sample collection at five different time points during gastric and intestinal digestion. Ten laboratories analysed all digesta with their in-house equipment and applying theirconventional workflow., The compiled results demonstrate in general, that soy proteins had a slower gastric digestion and the presence of longer peptide sequences in the intestinal phase compared to SMP or chicken proteins, suggesting a higher resistance to the digestion of soy proteins. Differences in results among the various laboratories were attributed more to the peptide selection criteria than to the individual analytical platforms. Overall, the combination of mass spectrometry techniques with suitable methodological and statistical approaches is adequate for contributing to the characterisation of the recently defined digestome.

Published
2023

41. New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation After Canine Gastrointestinal Simulated Digestion

Author

Theysgeur, Sandy, Cudennec, Benoit, Deracinois, Barbara, Perrin, Claire, Guiller, Isabelle, Lepoudère, Anne, Flahaut, Christophe, and Ravallec, Rozenn

Subjects
in vitro gastrointestinal digestion, Protein Hydrolysates, Swine, Dipeptidyl Peptidase 4, In Vitro Techniques, Cat Diseases, Article, Mass Spectrometry, Gastrointestinal Hormones, lcsh:QD241-441, Dogs, lcsh:Organic chemistry, Fish Products, Animals, Humans, Dog Diseases, Hydrolysis, digestive, oral, and skin physiology, DPP-IV inhibitory peptides, Biological Transport, Overweight, Animal Feed, glucagon-like peptide 1, cholecystokinin, Gastrointestinal Tract, Glucose, Cats, Caco-2 Cells, Peptides, bioactive peptides, fish byproduct hydrolysate, Tilapia
Abstract

Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related comorbidities like diabetes. In this work, a human in vitro static simulated gastrointestinal digestion model was adapted to the dog which allowed us to demonstrate the promising effects of a tilapia byproduct hydrolysate on the regulation of food intake and glucose metabolism. Promising effects on intestinal hormones secretion and dipeptidyl peptidase IV (DPP-IV) inhibitory activity were evidenced. We identify new bioactive peptides able to stimulate cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) secretions, and to inhibit the DPP-IV activity after a transport study through a Caco-2 cell monolayer.

Published
2021

42. Expression of concern: Particle-based photodynamic therapy based on indocyanine green modified plasmonic nanostructures for inactivation of a Crohn's disease-associated Escherichia coli strain.

Author

Jijie, Roxana, Dumych, Tetiana, Chengnan, Li, Bouckaert, Julie, Turcheniuk, Kostiantyn, Hage, Charles-Henri, Heliot, Laurent, Cudennec, Benoit, Dumitrascu, Nicoleta, Boukherroub, Rabah, and Szunerits, Sabine

Abstract

Expression of concern for 'Particle-based photodynamic therapy based on indocyanine green modified plasmonic nanostructures for inactivation of a Crohn's disease-associated Escherichia coli strain' by Roxana Jijie et al., J. Mater. Chem. B, 2016, 4, 2598–2605, https://doi.org/10.1039/C5TB02697K. [ABSTRACT FROM AUTHOR]

Published
2025
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43. Chicory: Understanding the Effects and Effectors of This Functional Food

Author

Pouille, Céline L., primary, Ouaza, Souad, additional, Roels, Elise, additional, Behra, Josette, additional, Tourret, Melissa, additional, Molinié, Roland, additional, Fontaine, Jean-Xavier, additional, Mathiron, David, additional, Gagneul, David, additional, Taminiau, Bernard, additional, Daube, Georges, additional, Ravallec, Rozenn, additional, Rambaud, Caroline, additional, Hilbert, Jean-Louis, additional, Cudennec, Benoit, additional, and Lucau-Danila, Anca, additional

Published
2022
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47. Explorative Screening of Bioactivities Generated by Plant-Based Proteins after In Vitro Static Gastrointestinal Digestion

Author

Dugardin, Camille, Cudennec, Benoit, Tourret, Mélissa, Caron, Juliette, Guérin-Deremaux, Laetitia, Behra-Miellet, Josette, Lefranc-Millot, Catherine, and Ravallec, Rozenn

Subjects
Protein Hydrolysates, Dipeptidyl Peptidase 4, biological activity, lcsh:TX341-641, Peptidyl-Dipeptidase A, Article, Antioxidants, Glucagon-Like Peptide 1, Animals, Humans, Mass Screening, ROS production, ACE, Plant Proteins, Dipeptidyl-Peptidase IV Inhibitors, IL-8, Diet, Vegetarian, Interleukin-8, fungi, CCK, food and beverages, Fabaceae, opioid receptor, Intestines, Whey Proteins, DPP-IV, inflammation, Receptors, Opioid, Cytokines, Digestion, Caco-2 Cells, Peptides, GLP-1, plant-based protein digestion, lcsh:Nutrition. Foods and food supply
Abstract

The gastrointestinal digestion of food proteins can generate peptides with a wide range of biological activities. In this study, we screened various potential bioactivities generated by plant-based proteins. Whey protein as an animal protein reference, five grades of pea protein, two grades of wheat protein, and potato, fava bean, and oat proteins were submitted to in vitro SGID. They were then tested in vitro for several bioactivities including measures on: (1) energy homeostasis through their ability to modulate intestinal hormone secretion, to inhibit DPP-IV activity, and to interact with opioid receptors, (2) anti-hypertensive properties through their ability to inhibit ACE activity, (3) anti-inflammatory properties in Caco-2 cells, (4) antioxidant properties through their ability to inhibit production of reactive oxygen species (ROS). Protein intestinal digestions were able to stimulate intestinal hormone secretion by enteroendocrine cells, to inhibit DPP-IV and ACE activities, to bind opioid receptors, and surprisingly, to decrease production of ROS. Neither pro- nor anti-inflammatory effects have been highlighted and some proteins lost their pro-inflammatory potential after digestion. The best candidates were pea, potato, and fava bean proteins.

Published
2020

48. Integrated Continuous Bioprocess Development for ACE-Inhibitory Peptide Production by Lactobacillus helveticus Strains in Membrane Bioreactor

Author

Raveschot, Cyril, Deracinois, Barbara, Bertrand, Emmeline, Flahaut, Christophe, Frémont, Marc, Drider, Djamel, Dhulster, Pascal, Cudennec, Benoit, and Coutte, François

Subjects
Lactobacillus, fermented milk, ACE-inhibitory peptides, food and beverages, Bioengineering and Biotechnology, gastrointestinal digestion, membrane bioreactor, Original Research
Abstract

Production of bioactive peptides (BAPs) by Lactobacillus species is a cost-effective approach compared to the use of purified enzymes. In this study, proteolytic Lactobacillus helveticus strains were used for milk fermentation to produce BAPs capable of inhibiting angiotensin converting enzyme (ACE). Fermented milks were produced in bioreactors using batch mode, and the resulting products showed significant ACE-inhibitory activities. However, the benefits of fermentation in terms of peptide composition and ACE-inhibitory activity were noticeably reduced when the samples (fermented milks and non-fermented controls) were subject to simulated gastrointestinal digestion (GID). Introducing an ultrafiltration step after fermentation allowed to prevent this effect of GID and restored the effect of fermentation. Furthermore, an integrated continuous process for peptide production was developed which led to a 3 fold increased peptide productivity compared to batch production. Using a membrane bioreactor allowed to generate and purify in a single step, an active ingredient for ACE inhibition.

Published
2020

49. Dataset on phenotypic characterization, on protein and genome analysis of three fluorescent Pseudomonas strains from mid-mountain water

Author

Dussert, Elodie, Tourret, Mélissa, Deracinois, Barbara, Duban, Matthieu, Leclère, Valérie, Cudennec, Benoit, Ravallec, Rozenn, Behra-Miellet, Josette, Institut Charles Viollette (ICV) - ULR 7394 (ICV), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), European Union, through the ERDF funding, Centrale Lille, Centre National de la Recherche Scientifique (CNRS), Lille University, Region Hauts-de-France, Centrale Initiative Foundation, and ANR-11-EQPX-0037,REALCAT,Plateforme intégREe AppLiquée au criblage haut débit de CATalyseurs pour les bioraffineries(2011)

Subjects
TOF/TOF, time-of-flight/time-of-flight, Proteomics, MS/MS, tandem mass spectrometry, PFF, peptide fragment fingerprinting, Spot no., spot number, NCBI, National Center for Biotechnology Information, R, reviewed, Genome sequencing, lcsh:Computer applications to medicine. Medical informatics, MW, molecular weight, Nb, number of experimental peptides recognized, ANI, average nucleotide identity, MALDI, matrix assisted laser desorption ionization, Bacterial identification, lcsh:Science (General), Immunology and Microbiology, [QFIN]Quantitative Finance [q-fin], [SDE.IE]Environmental Sciences/Environmental Engineering, P., Pseudomonas, Fluorescent Pseudomonas, MS, mass spectrometry, NR, not reviewed, PMF, peptide mass fingerprinting, lcsh:R858-859.7, ppm, parts per million, TCS, tetra correlation search, lcsh:Q1-390
Abstract

International audience; The identification of non-fermentative Gram negative bacilli from run-off and spring water, including fluorescent Pseudomonas is very complex and investigations are needed to contribute to the systematic of these bacteria. In this dataset, the phenotypical profiles of three strains isolated from Vosges mountains first identified as Pseudomonas fluorescens were determined using APIⓇ 50 CH galleries. Then, the identification of their proteins released directly into water was carried out using tandem/mass spectrometry after separating proteins on native two-dimensional polyacrylamide gels. Finally, genotypic analysis data is presented, that illustrates biodiversity in this fluorescent bacterial group. This data is referred by a research article entitled "Fluorescent Pseudomonas strains from mid-mountain water able to release antioxidant proteins directly into water".

Published
2020
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