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3. Case report: A novel PTCH1 frameshift mutation leading to nevoid basal cell carcinoma syndrome

Author

Lang, Xiaoqing, primary, Wang, Ting, additional, Guo, Shuping, additional, Dang, Yao, additional, Zhang, Yingjie, additional, Liu, Hongye, additional, He, Hongxia, additional, Li, Li, additional, Yuan, Huajie, additional, He, Ting, additional, Wang, Qiong, additional, Qin, Shiyu, additional, Cheng, Runping, additional, Yan, Xingquan, additional, and Cui, Hongzhou, additional

Published
2024
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6. Effects of biological agents on glycogen metabolism in psoriasis patients: A systematic review and meta‐analysis.

Author

He, Ting, Chang, Zhangqian, Zhang, Yingjie, Lang, Xiaoqing, Guo, Shuping, and Cui, Hongzhou

Subjects
GLYCOGEN, PSORIASIS, BLOOD sugar, BIOTHERAPY, METABOLISM
Abstract

The effectiveness and safety of biological agents for treating psoriasis have been confirmed; however, their effects on glucose metabolism biomarkers in psoriasis patients remain unclear. A systematic review and meta‐analysis were performed according to PRISMA guidelines. The final analysis enrolled 12 studies, including eight randomized controlled trial (RCT) (n = 5628 patients) and four observational cohort studies (OBSs) (n = 393 patients). The meta‐analysis comprising nine studies (six RCTs and three OBSs) revealed a slight reduction in the levels of HOMA‐IR associated with the use of biological therapies in OBS (biological therapies vs. traditional therapies: WMD = −0.2, CI = −0.10 to 0.50, p = 0.02). Although a considerable number of studies were analysed, our review did not show a significant alteration in HOMA‐IR levels among patients treated with biological therapies such as IL‐17 inhibitors and IL‐12/23 inhibitors at weeks 12–16 in RCTs. We also did not observe remarkable alterations in the fasting plasma glucose levels of patients in both OBS and RCT. Additional RCT on a larger scale and duration is required to provide more conclusive evidence regarding the effect of biological agents on glycogen metabolism in psoriasis. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Induction of T helper 17 cell response by interleukin-7 in patients with primary cutaneous melanoma

Author

Jinghong He, Yang Xiaofeng, Cui Hongzhou, Binjun Qiao, Yanzhen Wang, Junxia Qin, Liu Hongye, Guo Shuping, Ning Li, He Hongxia, and Xue Wenli

Subjects
Adult, Male, Cancer Research, Skin Neoplasms, medicine.medical_treatment, chemical and pharmacologic phenomena, Dermatology, Flow cytometry, Downregulation and upregulation, medicine, Humans, T helper 17 cell, Interleukin-7 receptor, Melanoma, medicine.diagnostic_test, business.industry, Interleukin-7, Interleukin, hemic and immune systems, Middle Aged, medicine.disease, Cytokine, Oncology, Cutaneous melanoma, Cancer research, Th17 Cells, Female, business
Abstract

Interleukin (IL)-7 plays a vital role in proliferation and activation of T cells, however, its signaling through CD127 is impaired in T cells in cancers and chronic infections. The mechanisms underlying T helper 17 (Th17) cell responses by IL-7 in melanoma remain not fully understood. The aim of this study was to assess the effect of IL-7 signaling on Th17 responses in patients with primary cutaneous melanoma. Healthy and primary cutaneous melanoma donors were selected for this study of Th17 cell function. IL-17+CD4+ Th17 cells and CD127 expression on Th17 cells were determined by flow cytometry. Cytokine level was measured by ELISA. Peripheral and tissue-infiltrating CD4+ T cells were isolated using magnetic beads, and then stimulated with IL-7 and/or signal transducer and activator of transcription 5 inhibitor. Activated signaling molecules were analyzed by flow cytometry. Peripheral and tumor-infiltrating Th17 cells percentage was decreased, while peripheral IL-7 level was also reduced in melanoma patients. There was no significant difference of CD127 expression on Th17 cells between melanoma patients and controls. Antiapoptotic protein Bcl-2 was downregulated, whereas proapoptotic protein-activated caspase-3 was upregulated in peripheral and tissue-infiltrating Th17 cells in melanoma patients. Higher concentration of IL-7 (10 ng/mL), but not lower IL-7 concentration (1 ng/mL), promoted Bcl-2 expression and decreased caspase-3 expression in Th17 cells in melanoma patients. Inhibition of signal transducer and activator of transcription 5 resulted in the downregulation of Bcl-2 while upregulation of caspase-3 in Th17 cells. The present data suggested that reduced IL-7 responsiveness might be insufficient for Th17 activation in patients with primary cutaneous melanoma.

Published
2021

12. Interleukin-7 regulates CD127 expression and promotes CD8+ T cell activity in patients with primary cutaneous melanoma.

Author

He, Hongxia, Qiao, Binjun, Guo, Shuping, Cui, Hongzhou, Zhang, Ziyan, and Qin, Junxia

Subjects
T cells, INTERLEUKIN-7, PHOSPHATIDYLINOSITOL 3-kinases, MELANOMA, MICROPHTHALMIA-associated transcription factor, LACTATE dehydrogenase
Abstract

Background: Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8+ T cell exhaustion. The mechanisms underlying CD8+ T cell responses to IL-7 in melanoma remain not completely elucidated. We previously showed reduced IL-7 level in melanoma patients. Thus, the aim of this study was to investigate the effect of IL-7 regulation on CD127 expression and CD8+ T cell responses in melanoma. Methods: Healthy controls and primary cutaneous melanoma patients were enrolled. Membrane-bound CD127 (mCD127) expression on CD8+ T cells was determined by flow cytometry. Soluble CD127 (sCD127) protein level was measured by ELISA. Total CD127 and sCD127 mRNA level was measured by real-time PCR. CD8+ T cells were stimulated with recombinant human IL-7, along with signaling pathway inhibitors. CD8+ T cells were co-cultured with melanoma cell line, and the cytotoxicity of CD8+ T cells was assessed by measurement of lactate dehydrogenase expression. Results: Plasma sCD127 was lower in melanoma patients compared with controls. The percentage of CD8+ T cells expressing mCD127 was higher, while sCD127 mRNA level was lower in peripheral and tumor-infiltrating CD8+ T cells from melanoma patients. There was no significant difference of total CD127 mRNA expression in CD8+ T cells between groups. IL-7 stimulation enhanced total CD127 and sCD127 mRNA expression and sCD127 release by CD8+ T cells. However, mCD127 mRNA expression on CD8+ T cells was not affected. This process was mainly mediated by phosphatidylinositol 3-kinase (PI3K) pathway. CD8+ T cells from melanoma patients exhibited decreased cytotoxicity. IL-7 stimulation promoted CD8+ T cell cytotoxicity, while inhibition of PI3K dampened IL-7-induced elevation of CD8+ T cell cytotoxicity. Conclusion: The current data suggested that insufficient IL-7 secretion might contribute to CD8+ T cell exhaustion and CD127 dysregulation in patients with primary cutaneous melanoma. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Exome sequencing identifies SLC17A9 pathogenic gene in two Chinese pedigrees with disseminated superficial actinic porokeratosis

Author

Cui, Hongzhou, Li, Longnian, Wang, Wenjun, Shen, Jie, Yue, Zhen, Zheng, Xiaodong, Zuo, Xianbo, Liang, Bo, Gao, Min, Fan, Xing, Yin, Xianyong, Shen, Changbing, Yang, Chao, Zhang, Change, Zhang, Xiaoguang, Sheng, Yujun, Gao, Jinping, Zhu, Zhengwei, Lin, Da, Zhang, Anping, Wang, Zaixing, Liu, Shengxiu, Sun, Liangdan, Yang, Sen, Cui, Yong, and Zhang, Xuejun

Published
2014
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18. Lab-on-a-chip technologies for genodermatoses: Recent progress and future perspectives

Author

Li Li, Ren Xiao-li, Guo Shu-ping, Li Jingmin, Wang Wenju, Cui Hongzhou, Deng Linjun, Wei Lulu, and Bai Li

Subjects
Surface Properties, Computer science, Point-of-Care Systems, DNA Mutational Analysis, Microfluidics, 02 engineering and technology, Dermatology, Asset (computer security), Bioinformatics, Polymerase Chain Reaction, 01 natural sciences, Biochemistry, Specimen Handling, law.invention, law, Lab-On-A-Chip Devices, Humans, Genetic Testing, Molecular Biology, Oligonucleotide Array Sequence Analysis, 010401 analytical chemistry, Skin Diseases, Genetic, Lab-on-a-chip, 021001 nanoscience & nanotechnology, Data science, Bench to bedside, 0104 chemical sciences, Mutation, 0210 nano-technology, Translation research
Abstract

In recent years, molecular biology has proven to be a great asset in our understanding of mechanisms in genodermatoses. However, bench to bedside translation research lags far behind. Advances in lab-on-a-chip technologies enabled programmable, reconfigurable, and scalable manipulation of a variety of laboratory procedures. Sample preparation, microfluidic reactions, and continuous monitoring systems can be integrated on a small chip. These advantages have attracted attention in various fields of clinical application including diagnosis of inherited skin diseases. This review lists an overview of the underlying genes and mutations and describes prospective application of lab-on-a-chip technologies as solutions to challenges for point-of-care genodematoses diagnosis.

Published
2017

20. The allele T of rs10852936 confers risk for early-onset psoriasis

Author

Li, Longnian, primary, Wang, Wenjun, additional, Cui, Hongzhou, additional, Zheng, Xiaodong, additional, Chen, Yan, additional, Sheng, Yujun, additional, Gao, Jinping, additional, Shen, Changbing, additional, Zeng, Ming, additional, Zhang, Tangde, additional, Sun, Liangdan, additional, and Zhang, Xuejun, additional

Published
2015
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21. Exome sequencing identifiesSLC17A9pathogenic gene in two Chinese pedigrees with disseminated superficial actinic porokeratosis

Author

Cui, Hongzhou, primary, Li, Longnian, additional, Wang, Wenjun, additional, Shen, Jie, additional, Yue, Zhen, additional, Zheng, Xiaodong, additional, Zuo, Xianbo, additional, Liang, Bo, additional, Gao, Min, additional, Fan, Xing, additional, Yin, Xianyong, additional, Shen, Changbing, additional, Yang, Chao, additional, Zhang, Change, additional, Zhang, Xiaoguang, additional, Sheng, Yujun, additional, Gao, Jinping, additional, Zhu, Zhengwei, additional, Lin, Da, additional, Zhang, Anping, additional, Wang, Zaixing, additional, Liu, Shengxiu, additional, Sun, Liangdan, additional, Yang, Sen, additional, Cui, Yong, additional, and Zhang, Xuejun, additional

Published
2014
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22. Sequencing-based approach identified three new susceptibility loci for psoriasis

Author

Sheng, Yujun, primary, Jin, Xin, additional, Xu, Jinhua, additional, Gao, Jinping, additional, Du, Xiaoqing, additional, Duan, Dawei, additional, Li, Bing, additional, Zhao, Jinhua, additional, Zhan, Wenying, additional, Tang, Huayang, additional, Tang, Xianfa, additional, Li, Yang, additional, Cheng, Hui, additional, Zuo, Xianbo, additional, Mei, Junpu, additional, Zhou, Fusheng, additional, Liang, Bo, additional, Chen, Gang, additional, Shen, Changbing, additional, Cui, Hongzhou, additional, Zhang, Xiaoguang, additional, Zhang, Change, additional, Wang, Wenjun, additional, Zheng, Xiaodong, additional, Fan, Xing, additional, Wang, Zaixing, additional, Xiao, Fengli, additional, Cui, Yong, additional, Li, Yingrui, additional, Wang, Jun, additional, Yang, Sen, additional, Xu, Lei, additional, Sun, Liangdan, additional, and Zhang, Xuejun, additional

Published
2014
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24. A comprehensive association analysis confirmsZMIZ1to be a susceptibility gene for vitiligo in Chinese population

Author

Sun, Yonghu, primary, Zuo, Xianbo, additional, Zheng, Xiaodong, additional, Zhou, Fusheng, additional, Liang, Bo, additional, Liu, Hong, additional, Chang, Ruixue, additional, Gao, Jinping, additional, Sheng, Yujun, additional, Cui, Hongzhou, additional, Wang, Wenjun, additional, Andiappan, Anand Kumar, additional, Rotzschke, Olaf, additional, Yang, Sen, additional, Sun, Liangdan, additional, Zhang, Furen, additional, Zhang, Xuejun, additional, Ren, Yunqing, additional, and Liu, Jianjun, additional

Published
2014
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25. Six Mutations in AAGAB Confirm Its Pathogenic Role in Chinese Punctate Palmoplantar Keratoderma Patients

Author

Cui, Hongzhou, primary, Gao, Min, additional, Wang, Wenjun, additional, Xiao, Ruo, additional, Chen, Gang, additional, Zhang, Qing, additional, Fu, Hongyang, additional, Zhou, Yi, additional, Guo, Birong, additional, Dong, Ying, additional, Shen, Jie, additional, Zhang, Min, additional, Yue, Zhen, additional, Liu, Fengxia, additional, Lin, Da, additional, Gao, Tianwen, additional, Zhang, Anping, additional, Zhou, Wenming, additional, Sun, Liangdan, additional, Yang, Sen, additional, Wang, Jun, additional, Cui, Yong, additional, and Zhang, Xuejun, additional

Published
2013
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27. Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

Author

Yang, Wanling, primary, Tang, Huayang, additional, Zhang, Yan, additional, Tang, Xianfa, additional, Zhang, Jing, additional, Sun, Liangdan, additional, Yang, Jing, additional, Cui, Yong, additional, Zhang, Lu, additional, Hirankarn, Nattiya, additional, Cheng, Hui, additional, Pan, Hai-Feng, additional, Gao, Jinping, additional, Lee, Tsz Leung, additional, Sheng, Yujun, additional, Lau, Chak Sing, additional, Li, Yang, additional, Chan, Tak Mao, additional, Yin, Xianyong, additional, Ying, Dingge, additional, Lu, Qianjin, additional, Leung, Alexander Moon Ho, additional, Zuo, Xianbo, additional, Chen, Xiang, additional, Tong, Kwok Lung, additional, Zhou, Fusheng, additional, Diao, Qingchun, additional, Tse, Niko Kei Chiu, additional, Xie, Hongfu, additional, Mok, Chi Chiu, additional, Hao, Fei, additional, Wong, Sik Nin, additional, Shi, Bingjun, additional, Lee, Ka Wing, additional, Hui, Yan, additional, Ho, Marco Hok Kung, additional, Liang, Bo, additional, Lee, Pamela Pui Wah, additional, Cui, Hongzhou, additional, Guo, Qing, additional, Chung, Brian Hon-Yin, additional, Pu, Xiongming, additional, Liu, Qiji, additional, Zhang, Xiaoguang, additional, Zhang, Change, additional, Chong, Chun Yin, additional, Fang, Hong, additional, Wong, Raymond Woon Sing, additional, Sun, Yonghu, additional, Mok, Mo Yin, additional, Li, Xiang-Pei, additional, Avihingsanon, Yingyos, additional, Zhai, Zhifang, additional, Rianthavorn, Pornpimol, additional, Deekajorndej, Thavatchai, additional, Suphapeetiporn, Kanya, additional, Gao, Fei, additional, Shotelersuk, Vorasuk, additional, Kang, Xiaojing, additional, Ying, Shirley King Yee, additional, Zhang, Lijuan, additional, Wong, Wilfred Hing Sang, additional, Zhu, Dingxian, additional, Fung, Samuel Ka Shun, additional, Zeng, Fanqin, additional, Lai, Wai Ming, additional, Wong, Chun-Ming, additional, Ng, Irene Oi Lin, additional, Garcia-Barceló, Maria-Mercè, additional, Cherny, Stacey S., additional, Shen, Nan, additional, Tam, Paul Kwong-Hang, additional, Sham, Pak Chung, additional, Ye, Dong-Qing, additional, Yang, Sen, additional, Zhang, Xuejun, additional, and Lau, Yu Lung, additional

Published
2013
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29. Construction of circular miRNA sponges targeting miR-21 or miR-221 and demonstration of their excellent anticancer effects on malignant melanoma cells.

Author

Liu, Yuchen, Cui, Hongzhou, Wang, Wenjun, Li, Longnian, Wang, Zaixing, Yang, Sen, and Zhang, Xuejun

Subjects
*MICRORNA, *ANTINEOPLASTIC agents, *MELANOMA, *CANCER cells, *RNA splicing, *EXONUCLEASES
Abstract

Highlights: [•] We produced circular miRNA sponges in cells using the synthetic splicing elements. [•] Circular sponges are completely resistant to miRNA-mediated degradation. [•] Circular sponges are more effective than typical technologies in inhibiting miRNA. [•] Circular sponges display superior anti-cancer activities in melanoma cells. [Copyright &y& Elsevier]

Published
2013
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30. SASH1 promotes melanin synthesis and migration via suppression of TGF-β1 secretion in melanocytes resulting in pathologic hyperpigmentation.

Author

Cui H, Guo S, He H, Guo H, Zhang Y, and Wang B

Subjects
Adolescent, Adult, Cell Movement physiology, Child, Female, Humans, Male, Signal Transduction physiology, Young Adult, Hyperpigmentation metabolism, Melanins metabolism, Melanocytes metabolism, Transforming Growth Factor beta1 metabolism, Tumor Suppressor Proteins metabolism
Abstract

Dyschromatosis universalis hereditaria (DUH) is an autosomal dominant pigmentary genodermatosis characterized by the presence of patches of hyperpigmentation and hypopigmented macules distributed over the body, with most cases reported in Asia. DUH is a heterogeneous disease and a small portion of patients carry the ABCB6 variant. In the present study, exome sequencing of four generations of a Chinese family with DUH identified a c.1761C>G (p.Ser587Arg) mutation in exon 15 of SAM and SH3 domain containing 1 (SASH1) that was found to co-segregate in some family members. Immunohistological analysis of biopsy specimens showed that SASH1 was diffusely distributed in all layers of the epidermis, suggesting increased transepithelial migration of melanocytes (MCs). The point mutation c.1761C>G of SASH1 was successfully induced in immortalized human melanocyte (PIG1) cells, which resulted in the downregulation of SASH1 expression. Bioinformatics analysis showed that mutated SASH1 downregulated thrombospondin 1 (THBS1) expression and inactivated transforming growth factor beta 1 (TGF-β1) signaling. TGF-β1 expression by PIG1cells was found to negatively regulate SASH1 protein expression. Transwell migration and wound-healing assays showed an increase in the migration and invasion capabilities of the cells carrying the mutation. Further, SASH1 mutations induced downregulation of melanin content. The study results suggest cross-talking between SASH1-TGF-β1 signaling, demonstrating the proposed MC migration modulation models and affecting melanin trafficking in the epithelium., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)

Published
2020
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