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21 results on '"Cui, Yan-Qiu"'

7. Chemical Composition and Antimicrobial Activity of Volatile Oil of Six Gymnosperm Species Leaves from Shanghai

Author

Cui Yan-qiu, Cui XinHong, Zhu Yi, Zhang Qun, and Nan Peng

Subjects
Limonene, beta-Pinene, alpha-Pinene, biology, biology.organism_classification, Antimicrobial, law.invention, Steam distillation, chemistry.chemical_compound, Gymnosperm, chemistry, law, Phellandrene, Botany, Antibacterial activity
Abstract

The chemical composition of six gymnosperm species, Sabina chinensis L. Art, Cedrus deodara Roxb G. Dor, S. chinensis (L.) Art, P. bungeana Zuccex Enall, Platgcladus orientalis Franco and Torryeya grandis Fortcv.Merrillii, and volatile oils obtained from the leaves by steam distillation was analysed using gas chromatograph and mass spectroscopy analysis (GC-MS). To evaluate in vitro antimicrobial activity, all volatile oils were tested against Gram-positive and Gram-negative bacteria. The volatile oils of six gymnosperm species leaves have exhibited antibacterial activity, especially the oils of Sabina chinensis L. Art, S. chinensis L. Ar.t and Platgcladus orientalis Franco have excellent antimicrobial activity against Gram-positive bacteria, such as S. epidermidis and S. aureus, it also indicated that the constituents such as bornyl acetate, phellandrene, limonene and alpha-pinene and beta-pinene could also contribute to the antimicrobial activity of the volatile oils.

Published
2008

18. Triptolide Rescues Spatial Memory Deficits and Amyloid-β Aggregation Accompanied by Inhibition of Inflammatory Responses and MAPKs Activity in APP/PS1 Transgenic Mice

Author

Cui, Yan-Qiu, Wang, Qi, Zhang, Dong-Mei, Wang, Jun-Ya, Xiao, Bing, Zheng, Yan, and Wang, Xiao-Min

Abstract

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease characterized by aggregation of amyloid-β (Aβ) peptide in the hippocampus and cortex of brain. Neuroinflammation is considered a driving force of the progression of cognitive decline in AD. During the neuroinflammatory process, activated astrocytes and microglia induced by Aβ peptide produce pro-inflammatory factors and neurotoxins, which promote neurodegeneration in AD brain, eventually dementia. Thus, the suppression of glial over-activation in AD brain might result in therapeutic effect. Triptolide, a natural compound extracted from the Chinese medicinal herb Tripterygium wilfordii Hook F., has shown anti-inflammatory effects. Whether triptolide exhibits preventive effects on AD-like pathology via anti-inflammatory action is unclear. The present study showed that intraperitoneal injection of triptolide (20 μg/kg) for 15 weeks markedly alleviated deficits in learning and memory, and prevented Aβ accumulation in the brain of AD transgenic mice (APP/PS1 mice). These results were accompanied by reduction in glial activation and contents of pro-inflammatory factors in the brain of APP/PS1 mice treated by triptolide compared to saline-treated APP/PS1 mice. In addition, we observed that the Mitogen-activated protein kinases (MAPKs, including p38, ERK and JNK) phosphorylation was also suppressed by treatment of triptolide in the brain of APP/PS1 mice. Taken together, our study suggests that molecular mechanisms underlying the therapeutic effects of triptolide on the AD model might involve inhibition of the neuroinflammation by suppressing MAPKs activity.

Published
2016

19. (5R)-5-hydroxytriptolide inhibits the inflammatory cascade reaction in astrocytes.

Author

Cui YQ, Zheng Y, Tan GL, Zhang DM, Wang JY, and Wang XM

Abstract

Many studies have shown that (5R)-5-hydroxytriptolide is the optimal modified analogue of triptolide, possessing comparable immunosuppressive activity but much lower cytotoxicity than triptolide. Whether (5R)-5-hydroxytriptolide has preventive effects on neuroinflammation is unclear. This study was designed to pretreat primary astrocytes from the brains of neonatal Sprague-Dawley rats with 20, 100 and 500 nM (5R)-5-hydroxytriptolide for 1 hour before establishing an in vitro neuroinflammation model with 1.0 μg/mL lipopolysaccharide for 24 hours. The generation of nitric oxide was detected by Griess reagents. Astrocyte marker glial fibrillary acidic protein was measured by immunohistochemical staining. The levels of tumor necrosis factor-α and interleukin-1β in the culture supernatant were assayed by enzyme linked immunosorbent assay. Nuclear factor-κB/p65 expression was examined by immunofluorescence staining. The phosphorylation of inhibitor of nuclear factor IκB-α and the location of nuclear factor-κB/P65 were determined using western blot assay. Our data revealed that (5R)-5-hydroxytriptolide inhibited the generation of nitric oxide, tumor necrosis factor-α and interleukin-1β from primary astrocytes activated by lipopolysaccharide, decreased the positive reaction intensity of glial fibrillary acidic protein, reduced the expression of tumor necrosis factor alpha and interleukin-1β in culture supernatant, inhibited the phosphorylation of IκB-α and the translocation of nuclear factor-κB/P65 to the nucleus. These results have confirmed that (5R)-5-hydroxytriptolide inhibits lipopolysaccharide-induced glial inflammatory response and provides cytological experimental data for (5R)-5-hydroxytriptolide in the treatment of neurodegenerative diseases., Competing Interests: None

Published
2019
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20. [The phenotypes of APPswe/PS1dE9 double transgenic mice].

Author

Cui YQ, Zheng Y, and Wang XM

Subjects
Animals, Humans, Mice, Mice, Transgenic, Mutation, Phenotype, Alzheimer Disease genetics, Alzheimer Disease physiopathology, Amyloid beta-Protein Precursor genetics, Disease Models, Animal, Presenilins genetics
Published
2012

21. [Fucoidan: advances in the study of its anti-inflammatory and anti-oxidative effects].

Author

Cui YQ, Luo DZ, and Wang XM

Subjects
Animals, Anti-Inflammatory Agents isolation & purification, Anti-Inflammatory Agents metabolism, Antioxidants isolation & purification, Polysaccharides isolation & purification, Polysaccharides metabolism, Reactive Oxygen Species metabolism, Receptors, Scavenger metabolism, Selectins metabolism, Anti-Inflammatory Agents pharmacology, Antioxidants pharmacology, Polysaccharides pharmacology, Seaweed chemistry
Abstract

Fucoidan is a natural polysaccharide extracted from brown seaweeds, with a wide variety of biological features, especially the anti-inflammatory and anti-oxidative effects. Studies indicated that the anti-inflammatory effect of fucoidan related to its capacity to interact with the selectin or scavenger receptor on the cell membrane. Fucoidan can also inhibit the synthesis and release of reactive oxygen species (ROS), as well as promote its clearance, showing the anti-oxidative activity.

Published
2008

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