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Background: Gastric adenocarcinoma of the fundic gland type (GA‐FG) is a newly described variant of gastric adenocarcinoma with lack of knowledges regarding its genetic features. Methods: We performed whole‐genome sequencing (WGS) in formalin‐fixed paraffin‐embedded (FFPE) tumor tissues and matched adjacent noncancerous specimens from 21 patients with GA‐FG, and integrated published datasets from 1105 patients with traditional gastric adenocarcinoma with the purpose of dissecting genetic determinants both common to conventional gastric adenocarcinoma and unique to GA‐FG disease. Results: We characterized the genomic architecture of GA‐FG disease, revealing the predominant proportion of C > T substitution among the six types of SNVs. GNAS was the most significantly mutated driver gene (14.29%). 42.8% of samples harbored "Kataegis." Distinct genomic alterations between GA‐FG and conventional gastric cancer were identified. Specifically, low mutational burden and relatively moderate mutational frequencies of significantly mutated driver genes, coupled with the absence of non‐silent alterations of formerly well‐known drivers such as TP53, PIK3CA and KRAS were identified in GA‐FG patients. Oncogenic signaling pathway analysis revealed mutational processes associated with focal adhesions and proteoglycans in cancer, highlighting both common and specific procedures during the development of GA‐FG and conventional gastric cancer. Conclusion: Our study is the first to comprehensively depict the genomic landscape highlighting the multidimensional perturbations in GA‐FG patients. These discoveries offered mechanistic insights for novel diagnostic and therapeutic strategies for patients with such disease. [ABSTRACT FROM AUTHOR]

Strobilanthes sarcorrhiza (CTS) is a medicinal plant with various pharmacological effects such as tonifying kidney and anti‐inflammatory. However, the chemical composition and difference of its four parts (leaves, stems, rhizomes, and root tubers) have been rarely reported. In this study, ultrafast flow liquid chromatography coupled with quadrupole‐time‐of‐flight MS was applied to analyze the chemical profile of CTS and identify 55 compounds, including terpenoids, phenylethanol glycosides, fatty acid derivatives, chain glycosides, flavonoid glycosides, and others. Among these compounds, 34 compounds were first identified in CTS. They were mainly terpenoids, phenylethanol glycosides, fatty acid derivatives, and so forth. Multivariate statistical analysis, such as principal component analysis and orthogonal partial least squares‐discriminant analysis were also used to evaluate the difference in chemical compounds from the four parts of CTS. The results showed that phenylethanol glycosides were the main compounds of the underground parts, while terpenoids were the main compounds of the aboveground parts. This study revealed the chemical diversity and similarity of CTS and suggested that the rhizomes could be used as an alternative medicinal part to improve the resource utilization of CTS. [ABSTRACT FROM AUTHOR]

35889296 11 Ni Z.H., Lv H.J., Yang G.Y. Recent Advances of Ti/Zr-Substituted Polyoxometalates: From Structural Diversity to Functional Applications. Guo-Yu Yang et al. [[5]] synthesized three new transition metal-substituted POM compounds. Polyoxometalates are a special class of soluble metal oxides (intermediate state) between monomeric metal oxides and infinite metal oxides, which have amazing differences in sizes, chemical compositions, and physical properties from monomeric and infinite metal oxides. All the previously reported Ge-V-O compounds were totally based on aliphatic organic ligands; compounds B 1 b and B 2 b are the first examples of Ge-V-O clusters containing aromatic organic ligands. [Extracted from the article]

Four coordination compounds, [Cu(Hmthd)2Cl]n (1), [Cu3(mthd)2Br]n (2), [Ag(mthd)]n (3), and [Ag2(mthd)I]n (4) (Hmthd = 2‐mercapto‐5‐methyl‐1,3,4‐thiadiazole), were synthesized and characterized by inductively coupled plasma (ICP) elemental analyses, powder X‐ray diffraction (PXRD), and Fourier transform infrared (FT‐IR) spectroscopies. These resulting coordination compounds can act as efficient catalysts for the oxidation of olefins with tert‐butyl hydroperoxide (TBHP) as oxidant. Wherein, compound 2 performed extremely enhanced catalytic activity for oxidation of styrene at 80°C. Moreover, the addition of an appropriate amount of acid can promote the protonation of ligands and activate the two Ag‐containing catalysts to improve their catalytic efficiencies. Experimental results indicate that catalyst 2 has a low activation energy and excellent recycle catalytic property. Radical trap experiments were performed to verify that free radicals participate in the oxidation of styrene. [ABSTRACT FROM AUTHOR]