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897 results on '"Culig, Zoran"'

1. Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells

Author

Drápela, Stanislav, Kvokačková, Barbora, Slabáková, Eva, Kotrbová, Anna, Gömöryová, Kristína, Fedr, Radek, Kurfürstová, Daniela, Eliáš, Martin, Študent jr, Vladimír, Lenčéšová, Frederika, Ranjani, Ganji Sri, Pospíchalová, Vendula, Bryja, Vítězslav, van Weerden, Wytske M., Puhr, Martin, Culig, Zoran, Bouchal, Jan, and Souček, Karel

Published
2024
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4. Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Author

Eigentler, Andrea, Handle, Florian, Schanung, Silvia, Degen, Antonia, Hackl, Hubert, Erb, Holger H. H., Fotakis, Georgios, Hoefer, Julia, Ploner, Christian, Jöhrer, Karin, Heidegger, Isabel, Pircher, Andreas, Klotz, Werner, Herold, Manfred, Schäfer, Georg, Culig, Zoran, and Puhr, Martin

Published
2024
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11. Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis

Author

Muresan, Ximena M., Slabáková, Eva, Procházková, Jiřina, Drápela, Stanislav, Fedr, Radek, Pícková, Markéta, Vacek, Ondřej, Víchová, Ráchel, Suchánková, Tereza, Bouchal, Jan, Kürfürstová, Daniela, Král, Milan, Hulínová, Tereza, Sýkora, Radek P., Študent, Vladimír, Hejret, Václav, van Weerden, Wytske M., Puhr, Martin, Pustka, Václav, Potěšil, David, Zdráhal, Zbyněk, Culig, Zoran, and Souček, Karel

Published
2022
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13. MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate Cancer.

Author

Andolfi, Chiara, Bartolini, Caterina, Morales, Elisa, Gündoğdu, Büşra, Puhr, Martin, Guzman, Juan, Wach, Sven, Taubert, Helge, Aigner, Achim, Eder, Iris E, Handle, Florian, and Culig, Zoran

Subjects
CANCER cell proliferation, PROSTATE cancer patients, CANCER patients, GENE expression, PROSTATE-specific antigen, ANDROGEN receptors
Abstract

Prostate cancer progression is driven by androgen receptor (AR) activity, which is a target for therapeutic approaches. Enzalutamide is an AR inhibitor that prolongs the survival of patients with advanced prostate cancer. However, resistance mechanisms arise and impair its efficacy. One of these mechanisms is the expression of AR-V7, a constitutively active AR splice variant. The Mediator complex is a multisubunit protein that modulates gene expression on a genome-wide scale. MED12 and cyclin-dependent kinase (CDK)8, or its paralog CDK19, are components of the kinase module that regulates the proliferation of prostate cancer cells. In this study, we investigated how MED12 and CDK8/19 influence cancer-driven processes in prostate cancer cell lines, focusing on AR activity and the enzalutamide response. We inhibited MED12 expression and CDK8/19 activity in LNCaP (AR+, enzalutamide-sensitive), 22Rv1 (AR-V7+, enzalutamide-resistant), and PC3 (AR−, enzalutamide-insensitive) cells. Both MED12 and CDK8/19 inhibition reduced cell proliferation in all cell lines, and MED12 inhibition reduced proliferation in the respective 3D spheroids. MED12 knockdown significantly inhibited c-Myc protein expression and signaling pathways. In 22Rv1 cells, it consistently inhibited the AR response, prostate-specific antigen (PSA) secretion, AR target genes, and AR-V7 expression. Combined with enzalutamide, MED12 inhibition additively decreased the AR activity in both LNCaP and 22Rv1 cells. CDK8/19 inhibition significantly decreased PSA secretion in LNCaP and 22Rv1 cells and, when combined with enzalutamide, additively reduced proliferation in 22Rv1 cells. Our study revealed that MED12 and CDK8/19 regulate AR activity and that their inhibition may modulate response to enzalutamide in prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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15. KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis

Author

Limberger, Tanja, Schlederer, Michaela, Trachtová, Karolina, Garces de los Fayos Alonso, Ines, Yang, Jiaye, Högler, Sandra, Sternberg, Christina, Bystry, Vojtech, Oppelt, Jan, Tichý, Boris, Schmeidl, Margit, Kodajova, Petra, Jäger, Anton, Neubauer, Heidi A., Oberhuber, Monika, Schmalzbauer, Belinda S., Pospisilova, Sarka, Dolznig, Helmut, Wadsak, Wolfgang, Culig, Zoran, Turner, Suzanne D., Egger, Gerda, Lagger, Sabine, and Kenner, Lukas

Published
2022
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16. Validation of a urine- based proteomics test to predict clinically significant prostate cancer: complementing MRI pathway

Author

Frantzi, Maria, primary, Morillo, Ana Christina, additional, Lendinez, Guillermo, additional, Blanca-Pedregosa, Ana, additional, Lopez Ruiz, Daniel, additional, Parada, Jose, additional, Heidegger, Isabel Maria, additional, Culig, Zoran, additional, Mavrogeorgis, Emmanouil, additional, Lopez Beltran, Antonio, additional, Mora-Ortiz, Marina, additional, Carrasco-Valiente, Julia, additional, Mischak, Harald, additional, Medina, Rafael A, additional, Campos Hernandez, Juan Pablo, additional, and Gomez Gomez, Enrique, additional

Published
2024
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22. Prevention and early detection of prostate cancer

Author

Cuzick, Jack, Thorat, Mangesh A, Andriole, Gerald, Brawley, Otis W, Brown, Powel H, Culig, Zoran, Eeles, Rosalind A, Ford, Leslie G, Hamdy, Freddie C, Holmberg, Lars, Ilic, Dragan, Key, Timothy J, La Vecchia, Carlo, Lilja, Hans, Marberger, Michael, Meyskens, Frank L, Minasian, Lori M, Parker, Chris, Parnes, Howard L, Perner, Sven, Rittenhouse, Harry, Schalken, Jack, Schmid, Hans-Peter, Schmitz-Dräger, Bernd J, Schröder, Fritz H, Stenzl, Arnulf, Tombal, Bertrand, Wilt, Timothy J, and Wolk, Alicja

Subjects
Aging, Prevention, Prostate Cancer, Urologic Diseases, Cancer, Detection, screening and diagnosis, 4.4 Population screening, Age Factors, Aged, Aged, 80 and over, Biomarkers, Tumor, Biopsy, Needle, Early Detection of Cancer, Evidence-Based Medicine, Humans, Immunohistochemistry, Life Style, Male, Middle Aged, Neoplasm Invasiveness, Primary Prevention, Prognosis, Prostate-Specific Antigen, Prostatic Neoplasms, Risk Factors, Risk Reduction Behavior, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control offer opportunities to reduce the risk of developing prostate cancer. Early detection of prostate cancer by prostate-specific antigen (PSA) screening is controversial, but changes in the PSA threshold, frequency of screening, and the use of other biomarkers have the potential to minimise the overdiagnosis associated with PSA screening. Several new biomarkers for individuals with raised PSA concentrations or those diagnosed with prostate cancer are likely to identify individuals who can be spared aggressive treatment. Several pharmacological agents such as 5α-reductase inhibitors and aspirin could prevent development of prostate cancer. In this Review, we discuss the present evidence and research questions regarding prevention, early detection of prostate cancer, and management of men either at high risk of prostate cancer or diagnosed with low-grade prostate cancer.

Published
2014

24. Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Author

Eigentler, Andrea, primary, Handle, Florian, additional, Schanung, Silvia, additional, Degen, Antonia, additional, Hackl, Hubert, additional, Erb, Holger H. H., additional, Fotakis, Georgios, additional, Hoefer, Julia, additional, Ploner, Christian, additional, Jöhrer, Karin, additional, Heidegger, Isabel, additional, Pircher, Andreas, additional, Klotz, Werner, additional, Herold, Manfred, additional, Schäfer, Georg, additional, Culig, Zoran, additional, and Puhr, Martin, additional

Published
2023
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25. MiRNA-mRNA integrative analysis reveals epigenetically regulated and prognostic miR-103a with a role in migration and invasion of carboplatin-resistant ovarian cancer cells that acquired mesenchymal-like phenotype

Author

Pernar Kovač, Margareta, primary, Tadić, Vanja, additional, Kralj, Juran, additional, Milković Periša, Marija, additional, Orešković, Slavko, additional, Babić, Ivan, additional, Banović, Vladimir, additional, Zhang, Wei, additional, Culig, Zoran, additional, and Brozovic, Anamaria, additional

Published
2023
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31. NanoLuc Binary Technology as a Methodological Approach: An Important New Tool for Studying the Localization of Androgen Receptor and Androgen Receptor Splice Variant V7 Homo- and Heterodimers

Author

Guzman, Juan, primary, Weigelt, Katrin, additional, Neumann, Angela, additional, Tripal, Philipp, additional, Schmid, Benjamin, additional, Winter, Zoltan, additional, Palmisano, Ralph, additional, Culig, Zoran, additional, Cronauer, Marcus V., additional, Muschler, Paul, additional, Wullich, Bernd, additional, Taubert, Helge, additional, and Wach, Sven, additional

Published
2023
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34. Supplementary Figure 2 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

Author

Santer, Frédéric R., primary, Höschele, Philipp P.S., primary, Oh, Su Jung, primary, Erb, Holger H.H., primary, Bouchal, Jan, primary, Cavarretta, Ilaria T., primary, Parson, Walther, primary, Meyers, David J., primary, Cole, Philip A., primary, and Culig, Zoran, primary

Published
2023
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36. Supplementary Figure 1 from The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models

Author

Handle, Florian, primary, Puhr, Martin, primary, Schaefer, Georg, primary, Lorito, Nicla, primary, Hoefer, Julia, primary, Gruber, Martina, primary, Guggenberger, Fabian, primary, Santer, Frédéric R., primary, Marques, Rute B., primary, van Weerden, Wytske M., primary, Claessens, Frank, primary, Erb, Holger H.H., primary, and Culig, Zoran, primary

Published
2023
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37. Supplementary Figure 2 from The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models

Author

Handle, Florian, primary, Puhr, Martin, primary, Schaefer, Georg, primary, Lorito, Nicla, primary, Hoefer, Julia, primary, Gruber, Martina, primary, Guggenberger, Fabian, primary, Santer, Frédéric R., primary, Marques, Rute B., primary, van Weerden, Wytske M., primary, Claessens, Frank, primary, Erb, Holger H.H., primary, and Culig, Zoran, primary

Published
2023
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39. Supplementary Figure 5 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

Author

Santer, Frédéric R., primary, Höschele, Philipp P.S., primary, Oh, Su Jung, primary, Erb, Holger H.H., primary, Bouchal, Jan, primary, Cavarretta, Ilaria T., primary, Parson, Walther, primary, Meyers, David J., primary, Cole, Philip A., primary, and Culig, Zoran, primary

Published
2023
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43. Supplementary Figure 1 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

Author

Santer, Frédéric R., primary, Höschele, Philipp P.S., primary, Oh, Su Jung, primary, Erb, Holger H.H., primary, Bouchal, Jan, primary, Cavarretta, Ilaria T., primary, Parson, Walther, primary, Meyers, David J., primary, Cole, Philip A., primary, and Culig, Zoran, primary

Published
2023
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44. Supplementary Figure 5 from The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models

Author

Handle, Florian, primary, Puhr, Martin, primary, Schaefer, Georg, primary, Lorito, Nicla, primary, Hoefer, Julia, primary, Gruber, Martina, primary, Guggenberger, Fabian, primary, Santer, Frédéric R., primary, Marques, Rute B., primary, van Weerden, Wytske M., primary, Claessens, Frank, primary, Erb, Holger H.H., primary, and Culig, Zoran, primary

Published
2023
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47. Supplementary Figure 3 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

Author

Santer, Frédéric R., primary, Höschele, Philipp P.S., primary, Oh, Su Jung, primary, Erb, Holger H.H., primary, Bouchal, Jan, primary, Cavarretta, Ilaria T., primary, Parson, Walther, primary, Meyers, David J., primary, Cole, Philip A., primary, and Culig, Zoran, primary

Published
2023
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48. Supplementary Table Legends 1-5 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

Author

Santer, Frédéric R., primary, Höschele, Philipp P.S., primary, Oh, Su Jung, primary, Erb, Holger H.H., primary, Bouchal, Jan, primary, Cavarretta, Ilaria T., primary, Parson, Walther, primary, Meyers, David J., primary, Cole, Philip A., primary, and Culig, Zoran, primary

Published
2023
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49. Supplementary Figure 4 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

Author

Santer, Frédéric R., primary, Höschele, Philipp P.S., primary, Oh, Su Jung, primary, Erb, Holger H.H., primary, Bouchal, Jan, primary, Cavarretta, Ilaria T., primary, Parson, Walther, primary, Meyers, David J., primary, Cole, Philip A., primary, and Culig, Zoran, primary

Published
2023
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50. Supplementary Figure 4 from The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models

Author

Handle, Florian, primary, Puhr, Martin, primary, Schaefer, Georg, primary, Lorito, Nicla, primary, Hoefer, Julia, primary, Gruber, Martina, primary, Guggenberger, Fabian, primary, Santer, Frédéric R., primary, Marques, Rute B., primary, van Weerden, Wytske M., primary, Claessens, Frank, primary, Erb, Holger H.H., primary, and Culig, Zoran, primary

Published
2023
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