Search

Your search keyword '"Cumberbatch, Marcus G"' showing total 160 results
Start Over Author "Cumberbatch, Marcus G"
160 results on '"Cumberbatch, Marcus G"'

2. Deconstructing, Addressing, and Eliminating Racial and Ethnic Inequities in Prostate Cancer Care

Author

Nyame, Yaw A., Cooperberg, Matthew R., Cumberbatch, Marcus G., Eggener, Scott E., Etzioni, Ruth, Gomez, Scarlett L., Haiman, Christopher, Huang, Franklin, Lee, Cheryl T., Litwin, Mark S., Lyratzopoulos, Georgios, Mohler, James L., Murphy, Adam B., Pettaway, Curtis, Powell, Isaac J., Sasieni, Peter, Schaeffer, Edward M., Shariat, Shahrokh F., and Gore, John L.

Published
2022
Full Text
View/download PDF

3. Protocol for CAMUS Delphi Study: A Consensus on Comprehensive Reporting and Grading of Complications After Urological Surgery

Author

Soliman, Christopher, Mulholland, Clancy J., Santaguida, Pasqualina, Sathianathen, Niranjan J., Lawrentschuk, Nathan, Giannarini, Gianluca, Wuethrich, Patrick Y., Loeffel, Lukas M., Cacciamani, Giovanni E., Pan, Henry Y.C., Nair, Rajesh, Cumberbatch, Marcus G., Riedel, Bernhard, Thomas, Benjamin C., Kearsley, Jamie, Corcoran, Niall, Dundee, Philip, and Furrer, Marc A.

Published
2022
Full Text
View/download PDF

4. Systematic Review of Active Surveillance for Clinically Localised Prostate Cancer to Develop Recommendations Regarding Inclusion of Intermediate-risk Disease, Biopsy Characteristics at Inclusion and Monitoring, and Surveillance Repeat Biopsy Strategy

Author

Willemse, Peter-Paul M., Davis, Niall F., Grivas, Nikolaos, Zattoni, Fabio, Lardas, Michael, Briers, Erik, Cumberbatch, Marcus G., De Santis, Maria, Dell'Oglio, Paolo, Donaldson, James F., Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grummet, Jeremy P., Henry, Ann M., Liew, Matthew, MacLennan, Steven, Mason, Malcolm D., Moris, Lisa, Plass, Karin, O'Hanlon, Shane, Omar, Muhammad Imran, Oprea-Lager, Daniela E., Pang, Karl H., Paterson, Catherine C., Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G., Tilki, Derya, van den Bergh, Roderick C.N., Van den Broeck, Thomas, van der Kwast, Theodorus H., van der Poel, Henk G., Wiegel, Thomas, Yuan, Cathy Yuhong, Cornford, Philip, Mottet, Nicolas, and Lam, Thomas B.L.

Published
2022
Full Text
View/download PDF

5. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

Author

Mottet, Nicolas, van den Bergh, Roderick C.N., Briers, Erik, Van den Broeck, Thomas, Cumberbatch, Marcus G., De Santis, Maria, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikos, Grummet, Jeremy, Henry, Ann M., van der Kwast, Theodorus H., Lam, Thomas B., Lardas, Michael, Liew, Matthew, Mason, Malcolm D., Moris, Lisa, Oprea-Lager, Daniela E., van der Poel, Henk G., Rouvière, Olivier, Schoots, Ivo G., Tilki, Derya, Wiegel, Thomas, Willemse, Peter-Paul M., and Cornford, Philip

Published
2021
Full Text
View/download PDF

6. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II—2020 Update: Treatment of Relapsing and Metastatic Prostate Cancer

Author

Cornford, Philip, van den Bergh, Roderick C.N., Briers, Erik, Van den Broeck, Thomas, Cumberbatch, Marcus G., De Santis, Maria, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Grummet, Jeremy, Henry, Ann M., der Kwast, Theodorus H. van, Lam, Thomas B., Lardas, Michael, Liew, Matthew, Mason, Malcolm D., Moris, Lisa, Oprea-Lager, Daniela E., der Poel, Henk G. van, Rouvière, Olivier, Schoots, Ivo G., Tilki, Derya, Wiegel, Thomas, Willemse, Peter-Paul M., and Mottet, Nicolas

Published
2021
Full Text
View/download PDF

7. Benefits and Risks of Primary Treatments for High-risk Localized and Locally Advanced Prostate Cancer: An International Multidisciplinary Systematic Review

Author

Moris, Lisa, Cumberbatch, Marcus G., Van den Broeck, Thomas, Gandaglia, Giorgio, Fossati, Nicola, Kelly, Brian, Pal, Raj, Briers, Erik, Cornford, Philip, De Santis, Maria, Fanti, Stefano, Gillessen, Silke, Grummet, Jeremy P., Henry, Ann M., Lam, Thomas B.L., Lardas, Michael, Liew, Matthew, Mason, Malcolm D., Omar, Muhammad Imran, Rouvière, Olivier, Schoots, Ivo G., Tilki, Derya, van den Bergh, Roderick C.N., van Der Kwast, Theodorus H., van Der Poel, Henk G., Willemse, Peter-Paul M., Yuan, Cathy Y., Konety, Badrinath, Dorff, Tanya, Jain, Suneil, Mottet, Nicolas, and Wiegel, Thomas

Published
2020
Full Text
View/download PDF

9. mRNA export and cancer

Author

Cumberbatch, Marcus G., Wilson, Stuart A., and Catto, James W. F.

Subjects
616.99
Abstract

Bladder cancer (BC) is the fourth commonest male malignancy worldwide and one of the most expensive to manage. The two greatest risk factors are tobacco smoking and occupational carcinogen exposure. In chapters 3 and 4, I contemporize the landscape of two leading causes for BC via a systematic review and meta-analysis of the published literature. I find that current smokers (versus ex-smokers or non-smokers) and those in tobacco, dye and factory industries have the greatest BC incidence. Carcinogenesis is the result of many molecular interactions and pathways that are not completely understood. Changes to RNA processing and transport are known to play a role in cancer biology. Transport of mRNA from the nucleus to the cytoplasm is essential for eukaryotic gene expression. ALYREF is central to the major mRNA export pathway involving the TREX complex; however, it is frequently down-regulated in high grade tumours. In chapter 5, we show that a previously uncharacterized cancer testis antigen LUZP4 defines a novel mRNA export pathway up-regulated in cancer. Post-translational modifications provide another level of gene expression control. In chapter 6, we show that poly (ADP-ribosyl)ation results in a global mRNA export block and alters TREX assembly by modifying the interaction between ALYREF and the RNA helicase UAP56 upon DNA damage. We show for the first time that PAR can bind UAP56 and identify the specific binding site. By advancing our knowledge of the LUZP4 mRNA export pathway and the effects of poly (ADP-ribosyl)ation on mRNA export we identify possible future targets for manipulation as biomarkers or therapeutic avenues.

Published
2016

10. A Systematic Review of the Efficacy and Toxicity of Brachytherapy Boost Combined with External Beam Radiotherapy for Nonmetastatic Prostate Cancer

Author

Slevin, Finbar, Zattoni, Fabio, Checcucci, Enrico, Cumberbatch, Marcus G K, Nacchia, Antonio, Cornford, Philip, Briers, Erik, De Meerleer, Gert, De Santis, Maria, Eberli, Daniel, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Liew, Matthew, Linares Espinós, Estefania E, Oldenburg, Jan, Oprea-Lager, Daniela E, Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G, Smith, Emma Jane, Stranne, Johan, Tilki, Derya, Smith, Catrin Tudur, Van Den Bergh, Roderick C N, Van Oort, Inge M, Wiegel, Thomas, Yuan, Cathy Y, Van den Broeck, Thomas, Henry, Ann M, Slevin, Finbar, Zattoni, Fabio, Checcucci, Enrico, Cumberbatch, Marcus G K, Nacchia, Antonio, Cornford, Philip, Briers, Erik, De Meerleer, Gert, De Santis, Maria, Eberli, Daniel, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Liew, Matthew, Linares Espinós, Estefania E, Oldenburg, Jan, Oprea-Lager, Daniela E, Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G, Smith, Emma Jane, Stranne, Johan, Tilki, Derya, Smith, Catrin Tudur, Van Den Bergh, Roderick C N, Van Oort, Inge M, Wiegel, Thomas, Yuan, Cathy Y, Van den Broeck, Thomas, and Henry, Ann M

Abstract

CONTEXT: The optimum use of brachytherapy (BT) combined with external beam radiotherapy (EBRT) for localised/locally advanced prostate cancer (PCa) remains uncertain. OBJECTIVE: To perform a systematic review to determine the benefits and harms of EBRT-BT. EVIDENCE ACQUISITION: Ovid MEDLINE, Embase, and EBM Reviews-Cochrane Central Register of Controlled Trials databases were systematically searched for studies published between January 1, 2000 and June 7, 2022, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Eligible studies compared low- or high-dose-rate EBRT-BT against EBRT ± androgen deprivation therapy (ADT) and/or radical prostatectomy (RP) ± postoperative radiotherapy (RP ± EBRT). The main outcomes were biochemical progression-free survival (bPFS), severe late genitourinary (GU)/gastrointestinal toxicity, metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS), at/beyond 5 yr. Risk of bias was assessed and confounding assessment was performed. A meta-analysis was performed for randomised controlled trials (RCTs). EVIDENCE SYNTHESIS: Seventy-three studies were included (two RCTs, seven prospective studies, and 64 retrospective studies). Most studies included participants with intermediate-or high-risk PCa. Most studies, including both RCTs, used ADT with EBRT-BT. Generally, EBRT-BT was associated with improved bPFS compared with EBRT, but similar MFS, CSS, and OS. A meta-analysis of the two RCTs showed superior bPFS with EBRT-BT (estimated fixed-effect hazard ratio [HR] 0.54 [95% confidence interval {CI} 0.40-0.72], p < 0.001), with absolute improvements in bPFS at 5-6 yr of 4.9-16%. However, no difference was seen for MFS (HR 0.84 [95% CI 0.53-1.28], p = 0.4) or OS (HR 0.87 [95% CI 0.63-1.19], p = 0.4). Fewer studies examined RP ± EBRT. There is an increased risk of severe late GU toxicity, especially with low-dose-rate EBRT-BT, with some evidence of increased pre

Published
2024

11. EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study)

Author

Lam, Thomas B.L., MacLennan, Steven, Willemse, Peter-Paul M., Mason, Malcolm D., Plass, Karin, Shepherd, Robert, Baanders, Ruud, Bangma, Chris H., Bjartell, Anders, Bossi, Alberto, Briers, Erik, Briganti, Alberto, Buddingh, Karel T., Catto, James W.F., Colecchia, Maurizio, Cox, Brett W., Cumberbatch, Marcus G., Davies, Jeff, Davis, Niall F., De Santis, Maria, Dell’Oglio, Paolo, Deschamps, André, Donaldson, James F., Egawa, Shin, Fankhauser, Christian D., Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Gross, Tobias, Grummet, Jeremy P., Henry, Ann M., Ingels, Alexandre, Irani, Jacques, Lardas, Michael, Liew, Matthew, Lin, Daniel W., Moris, Lisa, Omar, Muhammad Imran, Pang, Karl H., Paterson, Catherine C., Renard-Penna, Raphaële, Ribal, Maria J., Roobol, Monique J., Rouprêt, Morgan, Rouvière, Olivier, Sancho Pardo, Gemma, Richenberg, Jonathan, Schoots, Ivo G., Sedelaar, J.P. Michiel, Stricker, Phillip, Tilki, Derya, Vahr Lauridsen, Susanne, van den Bergh, Roderick C.N., Van den Broeck, Thomas, van der Kwast, Theodorus H., van der Poel, Henk G., van Leenders, Geert J.L.H., Varma, Murali, Violette, Philippe D., Wallis, Christopher J.D., Wiegel, Thomas, Wilkinson, Karen, Zattoni, Fabio, N’Dow, James M.O., Van Poppel, Hendrik, Cornford, Philip, and Mottet, Nicolas

Published
2019
Full Text
View/download PDF

13. Quality of Life Outcomes after Primary Treatment for Clinically Localised Prostate Cancer: A Systematic Review

Author

Lardas, Michael, Liew, Matthew, van den Bergh, Roderick C., De Santis, Maria, Bellmunt, Joaquim, Van den Broeck, Thomas, Cornford, Philip, Cumberbatch, Marcus G., Fossati, Nicola, Gross, Tobias, Henry, Ann M., Bolla, Michel, Briers, Erik, Joniau, Steven, Lam, Thomas B., Mason, Malcolm D., Mottet, Nicolas, van der Poel, Henk G., Rouvière, Olivier, Schoots, Ivo G., Wiegel, Thomas, Willemse, Peter-Paul M., Yuan, Cathy Yuhong, and Bourke, Liam

Published
2017
Full Text
View/download PDF

14. What Is the Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in Excluding Prostate Cancer at Biopsy? A Systematic Review and Meta-analysis from the European Association of Urology Prostate Cancer Guidelines Panel

Author

Moldovan, Paul C., Van den Broeck, Thomas, Sylvester, Richard, Marconi, Lorenzo, Bellmunt, Joaquim, van den Bergh, Roderick C.N., Bolla, Michel, Briers, Erik, Cumberbatch, Marcus G., Fossati, Nicola, Gross, Tobias, Henry, Ann M., Joniau, Steven, van der Kwast, Theo H., Matveev, Vsevolod B., van der Poel, Henk G., De Santis, Maria, Schoots, Ivo G., Wiegel, Thomas, Yuan, Cathy Yuhong, Cornford, Philip, Mottet, Nicolas, Lam, Thomas B., and Rouvière, Olivier

Published
2017
Full Text
View/download PDF

15. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

Author

Mottet, Nicolas, Bellmunt, Joaquim, Bolla, Michel, Briers, Erik, Cumberbatch, Marcus G., De Santis, Maria, Fossati, Nicola, Gross, Tobias, Henry, Ann M., Joniau, Steven, Lam, Thomas B., Mason, Malcolm D., Matveev, Vsevolod B., Moldovan, Paul C., van den Bergh, Roderick C.N., Van den Broeck, Thomas, van der Poel, Henk G., van der Kwast, Theo H., Rouvière, Olivier, Schoots, Ivo G., Wiegel, Thomas, and Cornford, Philip

Published
2017
Full Text
View/download PDF

16. Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019

Author

Conroy, Samantha, primary, Catto, James W.F., additional, Bex, Axel, additional, Brown, Janet E., additional, Cartledge, Jon, additional, Fielding, Alison, additional, Jones, Rob J., additional, Khoo, Vincent, additional, Nicol, David, additional, Stewart, Grant D., additional, Sullivan, Mark, additional, Tran, Maxine G.B., additional, Woodward, Rose, additional, and Cumberbatch, Marcus G., additional

Published
2023
Full Text
View/download PDF

17. Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system

Author

Jubber, Ibrahim, primary, Morhardt, Duncan R., additional, Griffin, Jonathan, additional, Cumberbatch, Marcus G., additional, Glover, Maggie, additional, Zheng, Yang, additional, Rehman, Ishtiaq, additional, Loynes, Catherine A., additional, Hussain, Syed A., additional, Renshaw, Stephen A., additional, Leach, Steven D., additional, Cunliffe, Vincent T., additional, and Catto, James W. F., additional

Published
2023
Full Text
View/download PDF

19. There is a Need for a Universal Language in the Reporting and Grading of Complication and Intervention Events to Ensure Comparability and Improvement of Surgical Care

Author

Soliman, Christopher, Sathianathen, Niranjan J, Giannarini, Gianluca, Wüthrich, Patrick Y, Pan, Henry Y C, Thomas, Benjamin C, Dundee, Philip, Cumberbatch, Marcus G, Nair, Rajesh, Lawrentschuk, Nathan, and Furrer, Marc A

Subjects
Postoperative Complications, Urology, Humans, Prospective Studies, 610 Medicine & health, Language
Abstract

To enhance the clarity and quality of complication reporting and grading for clinicians and patients, the CAMUS-Collaboration aims to develop the following: (1) a data dictionary; (2) parameters required for reporting; (3) risk-based reporting; (4) nursing and patient opinions; and (5) prospective reporting and grading of short- and long-term complications.

Published
2022
Full Text
View/download PDF

20. A Systematic Review of the Efficacy and Toxicity of Brachytherapy Boost Combined with External Beam Radiotherapy for Nonmetastatic Prostate Cancer

Author

Slevin, Finbar, Zattoni, Fabio, Checcucci, Enrico, Cumberbatch, Marcus G K, Nacchia, Antonio, Cornford, Philip, Briers, Erik, De Meerleer, Gert, De Santis, Maria, Eberli, Daniel; https://orcid.org/0000-0001-8866-8010, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Liew, Matthew, Linares Espinós, Estefania E, Oldenburg, Jan, Oprea-Lager, Daniela E, Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G, Smith, Emma Jane, Stranne, Johan, Tilki, Derya, Smith, Catrin Tudur, Van Den Bergh, Roderick C N, Van Oort, Inge M, Wiegel, Thomas, Yuan, Cathy Y, Van den Broeck, Thomas, Henry, Ann M, Slevin, Finbar, Zattoni, Fabio, Checcucci, Enrico, Cumberbatch, Marcus G K, Nacchia, Antonio, Cornford, Philip, Briers, Erik, De Meerleer, Gert, De Santis, Maria, Eberli, Daniel; https://orcid.org/0000-0001-8866-8010, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Liew, Matthew, Linares Espinós, Estefania E, Oldenburg, Jan, Oprea-Lager, Daniela E, Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G, Smith, Emma Jane, Stranne, Johan, Tilki, Derya, Smith, Catrin Tudur, Van Den Bergh, Roderick C N, Van Oort, Inge M, Wiegel, Thomas, Yuan, Cathy Y, Van den Broeck, Thomas, and Henry, Ann M

Abstract

CONTEXT: The optimum use of brachytherapy (BT) combined with external beam radiotherapy (EBRT) for localised/locally advanced prostate cancer (PCa) remains uncertain. OBJECTIVE: To perform a systematic review to determine the benefits and harms of EBRT-BT. EVIDENCE ACQUISITION: Ovid MEDLINE, Embase, and EBM Reviews-Cochrane Central Register of Controlled Trials databases were systematically searched for studies published between January 1, 2000 and June 7, 2022, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Eligible studies compared low- or high-dose-rate EBRT-BT against EBRT ± androgen deprivation therapy (ADT) and/or radical prostatectomy (RP) ± postoperative radiotherapy (RP ± EBRT). The main outcomes were biochemical progression-free survival (bPFS), severe late genitourinary (GU)/gastrointestinal toxicity, metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS), at/beyond 5 yr. Risk of bias was assessed and confounding assessment was performed. A meta-analysis was performed for randomised controlled trials (RCTs). EVIDENCE SYNTHESIS: Seventy-three studies were included (two RCTs, seven prospective studies, and 64 retrospective studies). Most studies included participants with intermediate-or high-risk PCa. Most studies, including both RCTs, used ADT with EBRT-BT. Generally, EBRT-BT was associated with improved bPFS compared with EBRT, but similar MFS, CSS, and OS. A meta-analysis of the two RCTs showed superior bPFS with EBRT-BT (estimated fixed-effect hazard ratio [HR] 0.54 [95% confidence interval {CI} 0.40-0.72], p < 0.001), with absolute improvements in bPFS at 5-6 yr of 4.9-16%. However, no difference was seen for MFS (HR 0.84 [95% CI 0.53-1.28], p = 0.4) or OS (HR 0.87 [95% CI 0.63-1.19], p = 0.4). Fewer studies examined RP ± EBRT. There is an increased risk of severe late GU toxicity, especially with low-dose-rate EBRT-BT, with some evidence of increased prevalenc

Published
2023

25. Systematic review of active surveillance for clinically localised prostate cancer to develop recommendations regarding inclusion of intermediate-risk disease, biopsy characteristics at inclusion and monitoring, and surveillance repeat biopsy strategy

Author

Tilki, Derya, Willemse, Peter-Paul M.; Davis, Niall F.; Grivas, Nikolaos; Zattoni, Fabio; Lardas, Michael; Briers, Erik; Cumberbatch, Marcus G.; De Santis, Maria; Dell'Oglio, Paolo; Donaldson, James F.; Fossati, Nicola; Gandaglia, Giorgio; Gillessen, Silke; Grummet, Jeremy P.; Henry, Ann M.; Liew, Matthew; MacLennan, Steven; Mason, Malcolm D.; Moris, Lisa; Plass, Karin; O'Hanlon, Shane; Omar, Muhammad Imran; Oprea-Lager, Daniela E.; Pang, Karl H.; Paterson, Catherine C.; Ploussard, Guillaume; Rouvière, Olivier; Schoots, Ivo G.; van den Bergh, Roderick C.N.; Van den Broeck, Thomas; van der Kwast, Theodorus H.; van der Poel, Henk G.; Wiegel, Thomas; Yuan, Cathy Yuhong; Cornford, Philip; Mottet, Nicolas; Lam, Thomas B.L., Koç University Hospital, School of Medicine, Tilki, Derya, Willemse, Peter-Paul M.; Davis, Niall F.; Grivas, Nikolaos; Zattoni, Fabio; Lardas, Michael; Briers, Erik; Cumberbatch, Marcus G.; De Santis, Maria; Dell'Oglio, Paolo; Donaldson, James F.; Fossati, Nicola; Gandaglia, Giorgio; Gillessen, Silke; Grummet, Jeremy P.; Henry, Ann M.; Liew, Matthew; MacLennan, Steven; Mason, Malcolm D.; Moris, Lisa; Plass, Karin; O'Hanlon, Shane; Omar, Muhammad Imran; Oprea-Lager, Daniela E.; Pang, Karl H.; Paterson, Catherine C.; Ploussard, Guillaume; Rouvière, Olivier; Schoots, Ivo G.; van den Bergh, Roderick C.N.; Van den Broeck, Thomas; van der Kwast, Theodorus H.; van der Poel, Henk G.; Wiegel, Thomas; Yuan, Cathy Yuhong; Cornford, Philip; Mottet, Nicolas; Lam, Thomas B.L., Koç University Hospital, and School of Medicine

Abstract

Context: there is uncertainty regarding the most appropriate criteria for recruitment, monitoring, and reclassification in active surveillance (AS) protocols for localised prostate cancer (PCa). Objective: to perform a qualitative systematic review (SR) to issue recommendations regarding inclusion of intermediate-risk disease, biopsy characteristics at inclusion and monitoring, and repeat biopsy strategy. Evidence acquisition: a protocol-driven, Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA)-adhering SR incorporating AS protocols published from January 1990 to October 2020 was performed. The main outcomes were criteria for inclusion of intermediate-risk disease, monitoring, reclassification, and repeat biopsy strategies (per protocol and/or triggered). Clinical effectiveness data were not assessed. Evidence synthesis: of the 17 011 articles identified, 333 studies incorporating 375 AS protocols, recruiting 264 852 patients, were included. Only a minority of protocols included the use of magnetic resonance imaging (MRI) for recruitment (n = 17), follow-up (n = 47), and reclassification (n = 26). More than 50% of protocols included patients with intermediate or high-risk disease, whilst 44.1% of protocols excluded low-risk patients with more than three positive cores, and 39% of protocols excluded patients with core involvement (CI) >50% per core. Of the protocols, ?80% mandated a confirmatory transrectal ultrasound biopsy; 72% (n = 189) of protocols mandated per-protocol repeat biopsies, with 20% performing this annually and 25% every 2 yr. Only 27 protocols (10.3%) mandated triggered biopsies, with 74% of these protocols defining progression or changes on MRI as triggers for repeat biopsy. Conclusions: for AS protocols in which the use of MRI is not mandatory or absent, we recommend the following: (1) AS can be considered in patients with low-volume International Society of Urological Pathology (ISUP) grade 2 (three or fewer positive cor, NA

Published
2022

26. Systematic Review of Active Surveillance for Clinically Localised Prostate Cancer to Develop Recommendations Regarding Inclusion of Intermediate-risk Disease, Biopsy Characteristics at Inclusion and Monitoring, and Surveillance Repeat Biopsy Strategy

Author

Willemse, Peter Paul M., Davis, Niall F., Grivas, Nikolaos, Zattoni, Fabio, Lardas, Michael, Briers, Erik, Cumberbatch, Marcus G., De Santis, Maria, Dell'Oglio, Paolo, Donaldson, James F., Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grummet, Jeremy P., Henry, Ann M., Liew, Matthew, MacLennan, Steven, Mason, Malcolm D., Moris, Lisa, Plass, Karin, O'Hanlon, Shane, Omar, Muhammad Imran, Oprea-Lager, Daniela E., Pang, Karl H., Paterson, Catherine C., Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G., Tilki, Derya, van den Bergh, Roderick C.N., Van den Broeck, Thomas, van der Kwast, Theodorus H., van der Poel, Henk G., Wiegel, Thomas, Yuan, Cathy Yuhong, Cornford, Philip, Mottet, Nicolas, Lam, Thomas B.L., Willemse, Peter Paul M., Davis, Niall F., Grivas, Nikolaos, Zattoni, Fabio, Lardas, Michael, Briers, Erik, Cumberbatch, Marcus G., De Santis, Maria, Dell'Oglio, Paolo, Donaldson, James F., Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grummet, Jeremy P., Henry, Ann M., Liew, Matthew, MacLennan, Steven, Mason, Malcolm D., Moris, Lisa, Plass, Karin, O'Hanlon, Shane, Omar, Muhammad Imran, Oprea-Lager, Daniela E., Pang, Karl H., Paterson, Catherine C., Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G., Tilki, Derya, van den Bergh, Roderick C.N., Van den Broeck, Thomas, van der Kwast, Theodorus H., van der Poel, Henk G., Wiegel, Thomas, Yuan, Cathy Yuhong, Cornford, Philip, Mottet, Nicolas, and Lam, Thomas B.L.

Abstract

Context: There is uncertainty regarding the most appropriate criteria for recruitment, monitoring, and reclassification in active surveillance (AS) protocols for localised prostate cancer (PCa). Objective: To perform a qualitative systematic review (SR) to issue recommendations regarding inclusion of intermediate-risk disease, biopsy characteristics at inclusion and monitoring, and repeat biopsy strategy. Evidence acquisition: A protocol-driven, Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA)-adhering SR incorporating AS protocols published from January 1990 to October 2020 was performed. The main outcomes were criteria for inclusion of intermediate-risk disease, monitoring, reclassification, and repeat biopsy strategies (per protocol and/or triggered). Clinical effectiveness data were not assessed. Evidence synthesis: Of the 17 011 articles identified, 333 studies incorporating 375 AS protocols, recruiting 264 852 patients, were included. Only a minority of protocols included the use of magnetic resonance imaging (MRI) for recruitment (n = 17), follow-up (n = 47), and reclassification (n = 26). More than 50% of protocols included patients with intermediate or high-risk disease, whilst 44.1% of protocols excluded low-risk patients with more than three positive cores, and 39% of protocols excluded patients with core involvement (CI) >50% per core. Of the protocols, ≥80% mandated a confirmatory transrectal ultrasound biopsy; 72% (n = 189) of protocols mandated per-protocol repeat biopsies, with 20% performing this annually and 25% every 2 yr. Only 27 protocols (10.3%) mandated triggered biopsies, with 74% of these protocols defining progression or changes on MRI as triggers for repeat biopsy. Conclusions: For AS protocols in which the use of MRI is not mandatory or absent, we recommend the following: (1) AS can be considered in patients with low-volume International Society of Urological Pathology (ISUP) grade 2 (three or fewer positi

Published
2022

27. Systematic Review of Active Surveillance for Clinically Localised Prostate Cancer to Develop Recommendations Regarding Inclusion of Intermediate-risk Disease, Biopsy Characteristics at Inclusion and Monitoring, and Surveillance Repeat Biopsy Strategy

Author

Zorgeenheid Urologie Zorg, MS Urologische Oncologie, Cancer, Researchgr. Nucleaire Geneeskunde, Willemse, Peter Paul M., Davis, Niall F., Grivas, Nikolaos, Zattoni, Fabio, Lardas, Michael, Briers, Erik, Cumberbatch, Marcus G., De Santis, Maria, Dell'Oglio, Paolo, Donaldson, James F., Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grummet, Jeremy P., Henry, Ann M., Liew, Matthew, MacLennan, Steven, Mason, Malcolm D., Moris, Lisa, Plass, Karin, O'Hanlon, Shane, Omar, Muhammad Imran, Oprea-Lager, Daniela E., Pang, Karl H., Paterson, Catherine C., Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G., Tilki, Derya, van den Bergh, Roderick C.N., Van den Broeck, Thomas, van der Kwast, Theodorus H., van der Poel, Henk G., Wiegel, Thomas, Yuan, Cathy Yuhong, Cornford, Philip, Mottet, Nicolas, Lam, Thomas B.L., Zorgeenheid Urologie Zorg, MS Urologische Oncologie, Cancer, Researchgr. Nucleaire Geneeskunde, Willemse, Peter Paul M., Davis, Niall F., Grivas, Nikolaos, Zattoni, Fabio, Lardas, Michael, Briers, Erik, Cumberbatch, Marcus G., De Santis, Maria, Dell'Oglio, Paolo, Donaldson, James F., Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grummet, Jeremy P., Henry, Ann M., Liew, Matthew, MacLennan, Steven, Mason, Malcolm D., Moris, Lisa, Plass, Karin, O'Hanlon, Shane, Omar, Muhammad Imran, Oprea-Lager, Daniela E., Pang, Karl H., Paterson, Catherine C., Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G., Tilki, Derya, van den Bergh, Roderick C.N., Van den Broeck, Thomas, van der Kwast, Theodorus H., van der Poel, Henk G., Wiegel, Thomas, Yuan, Cathy Yuhong, Cornford, Philip, Mottet, Nicolas, and Lam, Thomas B.L.

Published
2022

31. Effect of Robot-Assisted Radical Cystectomy With Intracorporeal Urinary Diversion vs Open Radical Cystectomy on 90-Day Morbidity and Mortality Among Patients With Bladder Cancer

Author

Catto, James W. F., Khetrapal, Pramit, Ricciardi, Federico, Ambler, Gareth, Williams, Norman R., Al-Hammouri, Tarek, Khan, Muhammad Shamim, Thurairaja, Ramesh, Nair, Rajesh, Feber, Andrew, Dixon, Simon, Nathan, Senthil, Briggs, Tim, Sridhar, Ashwin, Ahmad, Imran, Bhatt, Jaimin, Charlesworth, Philip, Blick, Christopher, Cumberbatch, Marcus G., Hussain, Syed A., Kotwal, Sanjeev, Koupparis, Anthony, McGrath, John, Noon, Aidan P., Rowe, Edward, Vasdev, Nikhil, Hanchanale, Vishwanath, Hagan, Daryl, Brew-Graves, Chris, and Kelly, John D.

Subjects
Socioeconomic Factors, Humans, General Medicine, Practice Patterns, Physicians', Original Investigation
Abstract

IMPORTANCE: Robot-assisted radical cystectomy is being performed with increasing frequency, but it is unclear whether total intracorporeal surgery improves recovery compared with open radical cystectomy for bladder cancer. OBJECTIVES: To compare recovery and morbidity after robot-assisted radical cystectomy with intracorporeal reconstruction vs open radical cystectomy. DESIGN, SETTING, AND PARTICIPANTS: Randomized clinical trial of patients with nonmetastatic bladder cancer recruited at 9 sites in the UK, from March 2017-March 2020. Follow-up was conducted at 90 days, 6 months, and 12 months, with final follow-up on September 23, 2021. INTERVENTIONS: Participants were randomized to receive robot-assisted radical cystectomy with intracorporeal reconstruction (n = 169) or open radical cystectomy (n = 169). MAIN OUTCOMES AND MEASURES: The primary outcome was the number of days alive and out of the hospital within 90 days of surgery. There were 20 secondary outcomes, including complications, quality of life, disability, stamina, activity levels, and survival. Analyses were adjusted for the type of diversion and center. RESULTS: Among 338 randomized participants, 317 underwent radical cystectomy (mean age, 69 years; 67 women [21%]; 107 [34%] received neoadjuvant chemotherapy; 282 [89%] underwent ileal conduit reconstruction); the primary outcome was analyzed in 305 (96%). The median number of days alive and out of the hospital within 90 days of surgery was 82 (IQR, 76-84) for patients undergoing robotic surgery vs 80 (IQR, 72-83) for open surgery (adjusted difference, 2.2 days [95% CI, 0.50-3.85]; P = .01). Thromboembolic complications (1.9% vs 8.3%; difference, –6.5% [95% CI, –11.4% to –1.4%]) and wound complications (5.6% vs 16.0%; difference, –11.7% [95% CI, –18.6% to –4.6%]) were less common with robotic surgery than open surgery. Participants undergoing open surgery reported worse quality of life vs robotic surgery at 5 weeks (difference in mean European Quality of Life 5-Dimension, 5-Level instrument scores, –0.07 [95% CI, –0.11 to –0.03]; P = .003) and greater disability at 5 weeks (difference in World Health Organization Disability Assessment Schedule 2.0 scores, 0.48 [95% CI, 0.15-0.73]; P = .003) and at 12 weeks (difference in WHODAS 2.0 scores, 0.38 [95% CI, 0.09-0.68]; P = .01); the differences were not significant after 12 weeks. There were no statistically significant differences in cancer recurrence (29/161 [18%] vs 25/156 [16%] after robotic and open surgery, respectively) and overall mortality (23/161 [14.3%] vs 23/156 [14.7%]), respectively) at median follow-up of 18.4 months (IQR, 12.8-21.1). CONCLUSIONS AND RELEVANCE: Among patients with nonmetastatic bladder cancer undergoing radical cystectomy, treatment with robot-assisted radical cystectomy with intracorporeal urinary diversion vs open radical cystectomy resulted in a statistically significant increase in days alive and out of the hospital over 90 days. However, the clinical importance of these findings remains uncertain. TRIAL REGISTRATION: ISRCTN Identifier: ISRCTN13680280; ClinicalTrials.gov Identifier: NCT03049410

Published
2022
Full Text
View/download PDF

32. A Systematic Review of Focal Ablative Therapy for Clinically Localised Prostate Cancer in Comparison with Standard Management Options: Limitations of the Available Evidence and Recommendations for Clinical Practice and Further Research

Author

Bates, Anthony S., primary, Ayers, Jennifer, additional, Kostakopoulos, Nikolaos, additional, Lumsden, Thomas, additional, Schoots, Ivo G., additional, Willemse, Peter-Paul M., additional, Yuan, Yuhong, additional, van den Bergh, Roderick C.N., additional, Grummet, Jeremy P., additional, van der Poel, Henk G., additional, Rouvière, Olivier, additional, Moris, Lisa, additional, Cumberbatch, Marcus G., additional, Lardas, Michael, additional, Liew, Matthew, additional, Van den Broeck, Thomas, additional, Gandaglia, Giorgio, additional, Fossati, Nicola, additional, Briers, Erik, additional, De Santis, Maria, additional, Fanti, Stefano, additional, Gillessen, Silke, additional, Oprea-Lager, Daniela E., additional, Ploussard, Guillaume, additional, Henry, Ann M., additional, Tilki, Derya, additional, van der Kwast, Theodorus H., additional, Wiegel, Thomas, additional, N’Dow, James, additional, Mason, Malcolm D., additional, Cornford, Philip, additional, Mottet, Nicolas, additional, and Lam, Thomas B.L., additional

Published
2021
Full Text
View/download PDF

33. A Systematic Review of Focal Ablative Therapy for Clinically Localised Prostate Cancer in Comparison with Standard Management Options:Limitations of the Available Evidence and Recommendations for Clinical Practice and Further Research

Author

Bates, Anthony S., Ayers, Jennifer, Kostakopoulos, Nikolaos, Lumsden, Thomas, Schoots, Ivo G., Willemse, Peter Paul M., Yuan, Yuhong, van den Bergh, Roderick C.N., Grummet, Jeremy P., van der Poel, Henk G., Rouvière, Olivier, Moris, Lisa, Cumberbatch, Marcus G., Lardas, Michael, Liew, Matthew, Van den Broeck, Thomas, Gandaglia, Giorgio, Fossati, Nicola, Briers, Erik, De Santis, Maria, Fanti, Stefano, Gillessen, Silke, Oprea-Lager, Daniela E., Ploussard, Guillaume, Henry, Ann M., Tilki, Derya, van der Kwast, Theodorus H., Wiegel, Thomas, N'Dow, James, Mason, Malcolm D., Cornford, Philip, Mottet, Nicolas, Lam, Thomas B.L., Bates, Anthony S., Ayers, Jennifer, Kostakopoulos, Nikolaos, Lumsden, Thomas, Schoots, Ivo G., Willemse, Peter Paul M., Yuan, Yuhong, van den Bergh, Roderick C.N., Grummet, Jeremy P., van der Poel, Henk G., Rouvière, Olivier, Moris, Lisa, Cumberbatch, Marcus G., Lardas, Michael, Liew, Matthew, Van den Broeck, Thomas, Gandaglia, Giorgio, Fossati, Nicola, Briers, Erik, De Santis, Maria, Fanti, Stefano, Gillessen, Silke, Oprea-Lager, Daniela E., Ploussard, Guillaume, Henry, Ann M., Tilki, Derya, van der Kwast, Theodorus H., Wiegel, Thomas, N'Dow, James, Mason, Malcolm D., Cornford, Philip, Mottet, Nicolas, and Lam, Thomas B.L.

Abstract

CONTEXT: The clinical effectiveness of focal therapy (FT) for localised prostate cancer (PCa) remains controversial. OBJECTIVE: To analyse the evidence base for primary FT for localised PCa via a systematic review (SR) to formulate clinical practice recommendations. EVIDENCE ACQUISITION: A protocol-driven, PRISMA-adhering SR comparing primary FT (sub-total, focal, hemi-gland, or partial ablation) versus standard options (active surveillance [AS], radical prostatectomy [RP], or external beam radiotherapy [EBRT]) was undertaken. Only comparative studies with ≥50 patients per arm were included. Primary outcomes included oncological, functional, and quality-of-life outcomes. Risk of bias (RoB) and confounding assessments were undertaken. Eligible SRs were reviewed and appraised (AMSTAR) and ongoing prospective comparative studies were summarised. EVIDENCE SYNTHESIS: Out of 1119 articles identified, four primary studies (1 randomised controlled trial [RCT] and 3 retrospective studies) recruiting 3961 patients and ten eligible SRs were identified. Only qualitative synthesis was possible owing to clinical heterogeneity. Overall, RoB and confounding were moderate to high. An RCT comparing vascular-targeted focal photodynamic therapy (PDT) with AS found a significantly lower rate of treatment failure at 2 yr with PDT. There were no differences in functional outcomes, although PDT was associated with worse transient adverse events. However, the external validity of the study was contentious. A retrospective study comparing focal HIFU with robotic RP found no significant differences in treatment failure at 3 yr, with focal HIFU having better continence and erectile function recovery. Two retrospective cohort studies using Surveillance, Epidemiology and End Results data compared focal laser ablation (FLA) against RP and EBRT, reporting significantly worse oncological outcomes for FLA. The overall data quality and applicability of the primary studies were limited because of c

Published
2021

34. A Systematic Review of Focal Ablative Therapy for Clinically Localised Prostate Cancer in Comparison with Standard Management Options: Limitations of the Available Evidence and Recommendations for Clinical Practice and Further Research

Author

MS Urologische Oncologie, Cancer, Bates, Anthony S, Ayers, Jennifer, Kostakopoulos, Nikolaos, Lumsden, Thomas, Schoots, Ivo G, Willemse, Peter-Paul M, Yuan, Yuhong, van den Bergh, Roderick C N, Grummet, Jeremy P, van der Poel, Henk G, Rouvière, Olivier, Moris, Lisa, Cumberbatch, Marcus G, Lardas, Michael, Liew, Matthew, Van den Broeck, Thomas, Gandaglia, Giorgio, Fossati, Nicola, Briers, Erik, De Santis, Maria, Fanti, Stefano, Gillessen, Silke, Oprea-Lager, Daniela E, Ploussard, Guillaume, Henry, Ann M, Tilki, Derya, van der Kwast, Theodorus H, Wiegel, Thomas, N'Dow, James, Mason, Malcolm D, Cornford, Philip, Mottet, Nicolas, Lam, Thomas B L, MS Urologische Oncologie, Cancer, Bates, Anthony S, Ayers, Jennifer, Kostakopoulos, Nikolaos, Lumsden, Thomas, Schoots, Ivo G, Willemse, Peter-Paul M, Yuan, Yuhong, van den Bergh, Roderick C N, Grummet, Jeremy P, van der Poel, Henk G, Rouvière, Olivier, Moris, Lisa, Cumberbatch, Marcus G, Lardas, Michael, Liew, Matthew, Van den Broeck, Thomas, Gandaglia, Giorgio, Fossati, Nicola, Briers, Erik, De Santis, Maria, Fanti, Stefano, Gillessen, Silke, Oprea-Lager, Daniela E, Ploussard, Guillaume, Henry, Ann M, Tilki, Derya, van der Kwast, Theodorus H, Wiegel, Thomas, N'Dow, James, Mason, Malcolm D, Cornford, Philip, Mottet, Nicolas, and Lam, Thomas B L

Published
2021

35. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

Author

Urologie Opleiding, MS Urologische Oncologie, Cancer, Mottet, Nicolas, van den Bergh, Roderick C N, Briers, Erik, Van den Broeck, Thomas, Cumberbatch, Marcus G, De Santis, Maria, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikos, Grummet, Jeremy, Henry, Ann M, van der Kwast, Theodorus H, Lam, Thomas B, Lardas, Michael, Liew, Matthew, Mason, Malcolm D, Moris, Lisa, Oprea-Lager, Daniela E, van der Poel, Henk G, Rouvière, Olivier, Schoots, Ivo G, Tilki, Derya, Wiegel, Thomas, Willemse, Peter-Paul M, Cornford, Philip, Urologie Opleiding, MS Urologische Oncologie, Cancer, Mottet, Nicolas, van den Bergh, Roderick C N, Briers, Erik, Van den Broeck, Thomas, Cumberbatch, Marcus G, De Santis, Maria, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikos, Grummet, Jeremy, Henry, Ann M, van der Kwast, Theodorus H, Lam, Thomas B, Lardas, Michael, Liew, Matthew, Mason, Malcolm D, Moris, Lisa, Oprea-Lager, Daniela E, van der Poel, Henk G, Rouvière, Olivier, Schoots, Ivo G, Tilki, Derya, Wiegel, Thomas, Willemse, Peter-Paul M, and Cornford, Philip

Published
2021

36. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II-2020 Update: Treatment of Relapsing and Metastatic Prostate Cancer[Formula presented]

Author

MS Urologische Oncologie, Cancer, Cornford, Philip, van den Bergh, Roderick C N, Briers, Erik, den Broeck, Thomas Van, Cumberbatch, Marcus G, De Santis, Maria, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Grummet, Jeremy, Henry, Ann M, der Kwast, Theodorus H van, Lam, Thomas B, Lardas, Michael, Liew, Matthew, Mason, Malcolm D, Moris, Lisa, Oprea-Lager, Daniela E, der Poel, Henk G van, Rouvière, Olivier, Schoots, Ivo G, Tilki, Derya, Wiegel, Thomas, Willemse, Peter-Paul M, Mottet, Nicolas, MS Urologische Oncologie, Cancer, Cornford, Philip, van den Bergh, Roderick C N, Briers, Erik, den Broeck, Thomas Van, Cumberbatch, Marcus G, De Santis, Maria, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Grummet, Jeremy, Henry, Ann M, der Kwast, Theodorus H van, Lam, Thomas B, Lardas, Michael, Liew, Matthew, Mason, Malcolm D, Moris, Lisa, Oprea-Lager, Daniela E, der Poel, Henk G van, Rouvière, Olivier, Schoots, Ivo G, Tilki, Derya, Wiegel, Thomas, Willemse, Peter-Paul M, and Mottet, Nicolas

Published
2021

38. Study Protocol for the DETECTIVE Study: An International Collaborative Study To Develop Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer

Author

Lam, Thomas B.L., MacLennan, Steven, Plass, Karin, Willemse, Peter-Paul M., Mason, Malcolm D., Cornford, Philip, Donaldson, James, Davis, Niall F., Dell’Oglio, Paolo, Fankhauser, Christian, Grivas, Nikos, Ingels, Alexandre, Lardas, Michael, Liew, Matthew, Pang, Karl H., Paterson, Catherine, Omar, Muhammad I., Zattoni, Fabio, Buddingh, Karel T., Van den Broeck, Thomas, Cumberbatch, Marcus G., Fossati, Nicola, Gross, Tobias, Moris, Lisa, Schoots, Ivo G., van den Bergh, Roderick C.N., Briers, Erik, Fanti, Stefano, De Santis, Maria, Gillessen, Silke, Grummet, Jeremy P., Henry, Ann M., van der Poel, Henk G., van der Kwast, Theodorus H., Rouvière, Olivier, Tilki, Derya, Wiegel, Thomas, N’Dow, James, Van Poppel, Hendrik, and Mottet, Nicolas

Published
2019
Full Text
View/download PDF

42. Re: Andrew Vickers, Sigrid V. Carlsson, Matthew Cooperberg. Routine Use of Magnetic Resonance Imaging for Early Detection of Prostate Cancer Is Not Justified by the Clinical Trial Evidence. Eur Urol 2020;78:304–6

Author

van den Bergh, Roderick C.N., primary, Rouvière, Olivier, additional, van der Kwast, Theodorus, additional, Briers, Erik, additional, Van den Broeck, Thomas, additional, Cornford, Philip, additional, Cumberbatch, Marcus G., additional, De Santis, Maria, additional, Fanti, Stefano, additional, Fossati, Nicola, additional, Gandaglia, Giorgio, additional, Grivas, Nikolaos, additional, Grummet, Jeremy, additional, Lam, Thomas B., additional, Lardas, Michael, additional, Liew, Matthew, additional, Moris, Lisa, additional, Mason, Malcolm D., additional, Mottet, Nicolas, additional, Oprea-Lager, Daniela E., additional, Ploussard, Guillaume, additional, Schoots, Ivo G., additional, Tilki, Derya, additional, van der Poel, Henk G., additional, Wiegel, Thomas, additional, and Willemse, Peter-Paul M., additional

Published
2020
Full Text
View/download PDF

43. Study Protocol for the DETECTIVE Study: An International Collaborative Study To Develop Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer

Author

Lam, Thomas B L, MacLennan, Steven, Plass, Karin, Willemse, Peter-Paul M, Mason, Malcolm D, Cornford, Philip, Donaldson, James, Davis, Niall F, Dell'Oglio, Paolo, Fankhauser, Christian, Grivas, Nikos, Ingels, Alexandre, Lardas, Michael, Liew, Matthew, Pang, Karl H, Paterson, Catherine, Omar, Muhammad I, Zattoni, Fabio, Buddingh, Karel T, Van den Broeck, Thomas, Cumberbatch, Marcus G, Fossati, Nicola, Gross, Tobias, Moris, Lisa, Schoots, Ivo G, van den Bergh, Roderick C N, Briers, Erik, Fanti, Stefano, De Santis, Maria, Gillessen, Silke, et al, University of Zurich, and Lam, Thomas B L

Subjects
2748 Urology, 10062 Urological Clinic, 610 Medicine & health
Published
2019
Full Text
View/download PDF

44. Benefits and Risks of Primary Treatments for High-risk Localized and Locally Advanced Prostate Cancer: An International Multidisciplinary Systematic Review

Author

MS Urologische Oncologie, Cancer, Moris, Lisa, Cumberbatch, Marcus G, Van den Broeck, Thomas, Gandaglia, Giorgio, Fossati, Nicola, Kelly, Brian, Pal, Raj, Briers, Erik, Cornford, Philip, De Santis, Maria, Fanti, Stefano, Gillessen, Silke, Grummet, Jeremy P, Henry, Ann M, Lam, Thomas B L, Lardas, Michael, Liew, Matthew, Mason, Malcolm D, Omar, Muhammad Imran, Rouvière, Olivier, Schoots, Ivo G, Tilki, Derya, van den Bergh, Roderick C N, van Der Kwast, Theodorus H, van Der Poel, Henk G, Willemse, Peter-Paul M, Yuan, Cathy Y, Konety, Badrinath, Dorff, Tanya, Jain, Suneil, Mottet, Nicolas, Wiegel, Thomas, MS Urologische Oncologie, Cancer, Moris, Lisa, Cumberbatch, Marcus G, Van den Broeck, Thomas, Gandaglia, Giorgio, Fossati, Nicola, Kelly, Brian, Pal, Raj, Briers, Erik, Cornford, Philip, De Santis, Maria, Fanti, Stefano, Gillessen, Silke, Grummet, Jeremy P, Henry, Ann M, Lam, Thomas B L, Lardas, Michael, Liew, Matthew, Mason, Malcolm D, Omar, Muhammad Imran, Rouvière, Olivier, Schoots, Ivo G, Tilki, Derya, van den Bergh, Roderick C N, van Der Kwast, Theodorus H, van Der Poel, Henk G, Willemse, Peter-Paul M, Yuan, Cathy Y, Konety, Badrinath, Dorff, Tanya, Jain, Suneil, Mottet, Nicolas, and Wiegel, Thomas

Published
2020

45. EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study)

Author

Lam, Thomas B L, MacLennan, Steven, Willemse, Peter-Paul M, Mason, Malcolm D, Plass, Karin, Shepherd, Robert, Baanders, Ruud, Bangma, Chris H, Bjartell, Anders, Bossi, Alberto, Briers, Erik, Briganti, Alberto, Buddingh, Karel T, Catto, James W F, Colecchia, Maurizio, Cox, Brett W, Cumberbatch, Marcus G, Davies, Jeff, Davis, Niall F, De Santis, Maria, Dell'Oglio, Paolo, Deschamps, André, Donaldson, James F, Egawa, Shin, Fankhauser, Christian D, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Gross, Tobias, Grummet, Jeremy P, Henry, Ann M, Ingels, Alexandre, Irani, Jacques, Lardas, Michael, Liew, Matthew, Lin, Daniel W, Moris, Lisa, Omar, Muhammad Imran, Pang, Karl H, Paterson, Catherine C, Renard-Penna, Raphaële, Ribal, Maria J, Roobol, Monique J, Rouprêt, Morgan, Rouvière, Olivier, Sancho Pardo, Gemma, Richenberg, Jonathan, Schoots, Ivo G, Sedelaar, J P Michiel, Stricker, Phillip, Tilki, Derya, Vahr Lauridsen, Susanne, van den Bergh, Roderick C N, Van den Broeck, Thomas, van der Kwast, Theodorus H, van der Poel, Henk G, van Leenders, Geert J L H, Varma, Murali, Violette, Philippe D, Wallis, Christopher J D, Wiegel, Thomas, Wilkinson, Karen, Zattoni, Fabio, N'Dow, James M O, Van Poppel, Hendrik, Cornford, Philip, Mottet, Nicolas, Lam, Thomas B L, MacLennan, Steven, Willemse, Peter-Paul M, Mason, Malcolm D, Plass, Karin, Shepherd, Robert, Baanders, Ruud, Bangma, Chris H, Bjartell, Anders, Bossi, Alberto, Briers, Erik, Briganti, Alberto, Buddingh, Karel T, Catto, James W F, Colecchia, Maurizio, Cox, Brett W, Cumberbatch, Marcus G, Davies, Jeff, Davis, Niall F, De Santis, Maria, Dell'Oglio, Paolo, Deschamps, André, Donaldson, James F, Egawa, Shin, Fankhauser, Christian D, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Gross, Tobias, Grummet, Jeremy P, Henry, Ann M, Ingels, Alexandre, Irani, Jacques, Lardas, Michael, Liew, Matthew, Lin, Daniel W, Moris, Lisa, Omar, Muhammad Imran, Pang, Karl H, Paterson, Catherine C, Renard-Penna, Raphaële, Ribal, Maria J, Roobol, Monique J, Rouprêt, Morgan, Rouvière, Olivier, Sancho Pardo, Gemma, Richenberg, Jonathan, Schoots, Ivo G, Sedelaar, J P Michiel, Stricker, Phillip, Tilki, Derya, Vahr Lauridsen, Susanne, van den Bergh, Roderick C N, Van den Broeck, Thomas, van der Kwast, Theodorus H, van der Poel, Henk G, van Leenders, Geert J L H, Varma, Murali, Violette, Philippe D, Wallis, Christopher J D, Wiegel, Thomas, Wilkinson, Karen, Zattoni, Fabio, N'Dow, James M O, Van Poppel, Hendrik, Cornford, Philip, and Mottet, Nicolas

Published
2019

46. Study Protocol for the DETECTIVE Study: An International Collaborative Study To Develop Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer

Author

MS Urologische Oncologie, Lam, Thomas B L, MacLennan, Steven, Plass, Karin, Willemse, Peter-Paul M, Mason, Malcolm D, Cornford, Philip, Donaldson, James, Davis, Niall F, Dell'Oglio, Paolo, Fankhauser, Christian, Grivas, Nikos, Ingels, Alexandre, Lardas, Michael, Liew, Matthew, Pang, Karl H, Paterson, Catherine, Omar, Muhammad I, Zattoni, Fabio, Buddingh, Karel T, Van den Broeck, Thomas, Cumberbatch, Marcus G, Fossati, Nicola, Gross, Tobias, Moris, Lisa, Schoots, Ivo G, van den Bergh, Roderick C N, Briers, Erik, Fanti, Stefano, De Santis, Maria, Gillessen, Silke, Grummet, Jeremy P, Henry, Ann M, van der Poel, Henk G, van der Kwast, Theodorus H, Rouvière, Olivier, Tilki, Derya, Wiegel, Thomas, N'Dow, James, Van Poppel, Hendrik, Mottet, Nicolas, MS Urologische Oncologie, Lam, Thomas B L, MacLennan, Steven, Plass, Karin, Willemse, Peter-Paul M, Mason, Malcolm D, Cornford, Philip, Donaldson, James, Davis, Niall F, Dell'Oglio, Paolo, Fankhauser, Christian, Grivas, Nikos, Ingels, Alexandre, Lardas, Michael, Liew, Matthew, Pang, Karl H, Paterson, Catherine, Omar, Muhammad I, Zattoni, Fabio, Buddingh, Karel T, Van den Broeck, Thomas, Cumberbatch, Marcus G, Fossati, Nicola, Gross, Tobias, Moris, Lisa, Schoots, Ivo G, van den Bergh, Roderick C N, Briers, Erik, Fanti, Stefano, De Santis, Maria, Gillessen, Silke, Grummet, Jeremy P, Henry, Ann M, van der Poel, Henk G, van der Kwast, Theodorus H, Rouvière, Olivier, Tilki, Derya, Wiegel, Thomas, N'Dow, James, Van Poppel, Hendrik, and Mottet, Nicolas

Published
2019

47. EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study)

Author

MS Urologische Oncologie, Lam, Thomas B L, MacLennan, Steven, Willemse, Peter-Paul M, Mason, Malcolm D, Plass, Karin, Shepherd, Robert, Baanders, Ruud, Bangma, Chris H, Bjartell, Anders, Bossi, Alberto, Briers, Erik, Briganti, Alberto, Buddingh, Karel T, Catto, James W F, Colecchia, Maurizio, Cox, Brett W, Cumberbatch, Marcus G, Davies, Jeff, Davis, Niall F, De Santis, Maria, Dell'Oglio, Paolo, Deschamps, André, Donaldson, James F, Egawa, Shin, Fankhauser, Christian D, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Gross, Tobias, Grummet, Jeremy P, Henry, Ann M, Ingels, Alexandre, Irani, Jacques, Lardas, Michael, Liew, Matthew, Lin, Daniel W, Moris, Lisa, Omar, Muhammad Imran, Pang, Karl H, Paterson, Catherine C, Renard-Penna, Raphaële, Ribal, Maria J, Roobol, Monique J, Rouprêt, Morgan, Rouvière, Olivier, Sancho Pardo, Gemma, Richenberg, Jonathan, Schoots, Ivo G, Sedelaar, J P Michiel, Stricker, Phillip, Tilki, Derya, Vahr Lauridsen, Susanne, van den Bergh, Roderick C N, Van den Broeck, Thomas, van der Kwast, Theodorus H, van der Poel, Henk G, van Leenders, Geert J L H, Varma, Murali, Violette, Philippe D, Wallis, Christopher J D, Wiegel, Thomas, Wilkinson, Karen, Zattoni, Fabio, N'Dow, James M O, Van Poppel, Hendrik, Cornford, Philip, Mottet, Nicolas, MS Urologische Oncologie, Lam, Thomas B L, MacLennan, Steven, Willemse, Peter-Paul M, Mason, Malcolm D, Plass, Karin, Shepherd, Robert, Baanders, Ruud, Bangma, Chris H, Bjartell, Anders, Bossi, Alberto, Briers, Erik, Briganti, Alberto, Buddingh, Karel T, Catto, James W F, Colecchia, Maurizio, Cox, Brett W, Cumberbatch, Marcus G, Davies, Jeff, Davis, Niall F, De Santis, Maria, Dell'Oglio, Paolo, Deschamps, André, Donaldson, James F, Egawa, Shin, Fankhauser, Christian D, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Gross, Tobias, Grummet, Jeremy P, Henry, Ann M, Ingels, Alexandre, Irani, Jacques, Lardas, Michael, Liew, Matthew, Lin, Daniel W, Moris, Lisa, Omar, Muhammad Imran, Pang, Karl H, Paterson, Catherine C, Renard-Penna, Raphaële, Ribal, Maria J, Roobol, Monique J, Rouprêt, Morgan, Rouvière, Olivier, Sancho Pardo, Gemma, Richenberg, Jonathan, Schoots, Ivo G, Sedelaar, J P Michiel, Stricker, Phillip, Tilki, Derya, Vahr Lauridsen, Susanne, van den Bergh, Roderick C N, Van den Broeck, Thomas, van der Kwast, Theodorus H, van der Poel, Henk G, van Leenders, Geert J L H, Varma, Murali, Violette, Philippe D, Wallis, Christopher J D, Wiegel, Thomas, Wilkinson, Karen, Zattoni, Fabio, N'Dow, James M O, Van Poppel, Hendrik, Cornford, Philip, and Mottet, Nicolas

Published
2019

49. Re: Andrew Vickers, Sigrid V. Carlsson, Matthew Cooperberg. Routine Use of Magnetic Resonance Imaging for Early Detection of Prostate Cancer Is Not Justified by the Clinical Trial Evidence. Eur Urol 2020;78:304–6: Prebiopsy MRI: Through the Looking Glass

Author

Briers, Erik, Van den Broeck, Thomas, Cornford, Philip, Cumberbatch, Marcus G., De Santis, Maria, Fanti, Stefano, Fossati, Nicola, Gandaglia, Giorgio, Grivas, Nikolaos, Grummet, Jeremy, Lam, Thomas B., Lardas, Michael, Liew, Matthew, Moris, Lisa, Mason, Malcolm D., Mottet, Nicolas, Oprea-Lager, Daniela E., Ploussard, Guillaume, Schoots, Ivo G., Tilki, Derya, van der Poel, Henk G., Wiegel, Thomas, Willemse, Peter-Paul M., van den Bergh, Roderick C.N., Rouvière, Olivier, and van der Kwast, Theodorus

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results