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Estimating the biological sex is one of the key objectives in a forensic investigation involving unidentified human skeletal remains. The femur is sexually dimorphic and has been extensively employed for the assessment of sex in different populations. The purposes of this article include a detailed macroanatomical characterization of the femur in a modern reference sample of the Spanish population (N = 226; Cemetery of San José in Granada, housed in the Physical Anthropology Laboratory of the University of Granada), based on 15 measurements of the proximal, distal and diaphyseal regions, and the development of univariable and multivariable models that enable the prediction of sex from complete or fragmentary femora. Univariable models were developed with C4.5, a decision-tree algorithm. Furthermore, univariable and multivariable models were generated through logistic regression (LR) with stepwise selection procedures. The models were able to correctly estimate sex in up to 91.2% of the individuals, providing high classification accuracy and low bias under cross-validation. Logistic regression models provide a probabilistic estimate of sex, that acknowledges both the Daubert standard and the fact that biological sex is not strictly dichotomous. [ABSTRACT FROM AUTHOR]

Forensic anthropology involves analysing human skeletal remains to assist legal investigations, with sex estimation being a key component of constructing a biological profile. This study evaluated the feasibility of developing metric methods for sex estimation using femora and humeri across different populations. Logistic regression models were created from Portuguese training samples (360 femora; 329 humeri) and tested on independent Portuguese (200 femora; 150 humeri) and South African (66 femora; 66 humeri) samples. The primary goal was to develop sex estimation models using pooled data from Portuguese samples and assess their reliability across Portuguese and South African populations. Femoral models for the Portuguese testing sample achieved an accuracy between 82.0% and 85.5%, with sex bias from 0.0% to 8.0%. Humeral models showed higher accuracy, between 88.0% and 94.0%, with sex bias from 2.4% to 13.1%. In the South African sample, both femoral and humeral models exceeded 75.0% accuracy but exhibited notable sex bias. The results suggest that using a heterogeneous training set, combining data from diverse populations, offers a broader understanding of sexual dimorphism compared with a homogeneous dataset from a single group. The study emphasizes that relying solely on skeletal samples from one population is insufficient for modern forensic anthropology standards. [ABSTRACT FROM AUTHOR]

Congenital skeletal disorders are a heterogeneous group of anomalies that become evident during gestation. They are expressed in the shape and growth of the bones during development because of a defective genetic background. With the follow‐up of pregnant women and the advances in prenatal ultrasonographic examination and molecular genetic tests, nowadays, congenital skeletal disorders are identified at an early gestational age. If they are considered lethal, the termination of pregnancy is advised. This work unveils an exceptional instance of a rare pathological condition identified in a perinate (birth ± 2 weeks) from the 17th to 19th centuries, recovered during an excavation at the cloister of the São Domingos Convent in Lisbon, Portugal. The skeleton presents with exuberant modifications that include, among others, severe shortening (micromelia) and bowing of the long bones of the upper and lower limbs. The main skeletal findings indicated a presumptive general diagnosis of skeletal dysplasia, while the differential diagnosis includes hypophosphatasia, campomelic dysplasia, achondrogenesis, thanatophoric dysplasia, and severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) as the most plausible causes for the observed skeletal changes. Even though an exact diagnosis is unattainable based only on the macroscopic analysis of the bones, the phenotypic features observed in this perinate are more consistent with thanatophoric dysplasia type 1. [ABSTRACT FROM AUTHOR]

Identification of unidentified remains involves a comparison of ante- and postmortem features using biological identifiers. Anthropological identifiers, referred to by International Criminal Police Organization (INTERPOL) as secondary identifiers, have often been judged less reliable than DNA, fingerprints and dental records (referred to as primary identifiers). However, anthropological identifiers have been proven as discriminatory as the primary sources in many instances, and play a decisive role in positive identification. To guarantee better use of anthropological identifiers, it is not only essential to develop standard protocols and statistical frameworks, but also to test different identification approaches in cases from daily practice. Evidence of skeletal antemortem trauma can be a valuable aid in the identification process, especially if the exact type of traumatic event causing the injury is identified. Here, we present a case in which the combination of anthropological analysis and imaging confirmed an interesting and unique sequence of antemortem traumatic events in incomplete skeletal remains. The remains were assumed to pertain to an individual who went missing several years earlier, and whose medical records revealed a unique history of trauma to the right femur. The individual had sustained a fracture due to a fall from a high height followed, 10 years after the primary trauma, by a gunshot wound to the same bone; both treated by intramedullary nail fixation. While the anthropological analysis matched the biological profile of the missing individual and identified a healed defect to the right femur compatible with a gunshot wound, the radiological examination indicated that the bone underwent three surgical procedures on different occasions. Radiological examination also identified a pre-existing healed fracture adjacent to the gunshot defect. In addition to presenting the identification process in this specific case, this article discusses the difficulties in antemortem trauma interpretation, importance of combining macroscopic and radiological analysis to aid the reconstruction of previous traumatic events and mechanisms of injury from healed fractures that can play important roles in forensic human identification. [ABSTRACT FROM AUTHOR]

This article presents a series of three complex forensic cases that posed significant challenges for identifying human remains. These include a mass dam disaster, burnt human remains, and extensively decomposed human remains. Positive identification was achieved using a shadow positioning technique with imaging comparisons of medical findings. After establishing the biological profile, medical data were evaluated with digital radiography and computed tomography examinations the human remains. These aimed to replicate the original (intravitam) traits in the same angulation to examine postsurgical characteristics, as well as the anatomical, pathological, and morphological features, which were sufficient to establish a positive scientific identification. Technological advancements tend to reveal additional skeletal details, making medical data comparisons significantly more effective in the context of anthropological identification. These cases demonstrate that the possibility of identification should never be ignored, even in situations with advanced decomposition. Key points Conventional identification methods may not always be applicable in forensic anthropology cases. The presented cases include a mass dam disaster, burnt human remains, and extensively decomposed human remains. These three cases involved successful human identification with medical findings comparisons using the shadow position technique. Identification could be established in these cases, despite challenges, such as fire damage, an incomplete body, and extensive decomposition. These cases suggest medical findings should be considered as biological identifiers rather than secondary identifiers. [ABSTRACT FROM AUTHOR]

Age assessment of the living is a fundamental procedure in the process of human identification, in order to guarantee fair treatment of individuals, which has ethical, civil, legal, and medical repercussions. The careful selection of the appropriate methods requires evaluation of several parameters: accuracy, precision of the method, as well as its reproducibility. The approach proposed by Mincer et al. adapted from Demirjian et al. exploring third molar mineralisation, is one of the most frequently considered for age estimation of the living. Thus, this work aims to assess potential bias in the data collection when applying the classification stages for dental mineralisation adapted by Mincer et al. A total of 102 orthopantomographs, of clinical origin, belonging to individuals aged between 12 and 25 years (⁠|$ \bar{\textit x} $| = 20.12 years, SD = 3.49 years; 65 females, 37 males, all of Portuguese nationality) were included and a retrospective analysis performed by five observers with different levels of experience (high, average, and basic). The performance and agreement between five observers were evaluated using Weighted Cohen's Kappa and the Intraclass Correlation Coefficient. To access the influence of impaction on third molar classification, variables were tested using ordinal logistic regression Generalised Linear Model. It was observed that there were variations in the number of teeth identified among the observers, but the agreement levels ranged from moderate to substantial (0.4–0.8). Upon closer examination of the results, it was observed that although there were discernible differences between highly experienced observers and those with less experience, the gap was not as significant as initially hypothesised, and a greater disparity between the classifications of the upper (0.24–0.49) and lower third molars (>0.55) was observed. When bone superimposition is present, the classification process is not significantly influenced; however, variation in teeth angulation affects the assessment. The results suggest that with an efficient preparation, the level of experience as a factor can be overcome. Mincer and colleague's classification system can be replicated with ease and consistency, even though the classification of upper and lower third molars presents distinct challenges. [ABSTRACT FROM AUTHOR]