7 results on '"Cunha, Roberto Sá"'
Search Results
2. Arterial stiffness in black adults from Angola and Brazil
- Author
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Cruz, Vitória P. D., primary, Gonzaga, Carla W. O., additional, Silva, Victor B., additional, Cruz, André F. P., additional, Silva, Amilcar B. Tomé, additional, Capingana, Daniel P., additional, Magalhães, Pedro, additional, Zaniqueli, Divanei A., additional, Guimarães, André L. S., additional, Cunha, Roberto Sá, additional, Mill, José Geraldo, additional, and Baldo, Marcelo P., additional
- Published
- 2020
- Full Text
- View/download PDF
3. Excess weight in children and adolescents is associated with altered subendocardial blood supply among girls but not boys.
- Author
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Zaniqueli, Divanei, Alvim, Rafael O., Baldo, Marcelo P., Luiz, Sara G., Cunha, Roberto Sá, and Mill, José G.
- Subjects
HEMODYNAMICS ,CHILDHOOD obesity ,PURKINJE fibers ,WEIGHT gain ,HEART beat - Abstract
Summary: Subendocardial viability ratio (SEVR) is a reliable index of myocardial supply‐workload balance. This study sought to investigate whether overweight/obese children and adolescents have altered SEVR and to identify which are the associated factors. This cross‐sectional study involved 789 individuals. Central haemodynamic was measured by radial applanation tonometry. Diastolic time was shorter (496 ± 122 vs 537 ± 140 ms,
P = .014) and diastolic pressure‐time index was lower (2681 ± 412 vs 2814 ± 423 mm Hg seconds,P = .024) in overweight/obese compared with eutrophic girls. SEVR was lower in girls than in boys (1.34 ± 0.39 vs 1.48 ± 0.41,P = .018) but only among overweight/obese. SEVR may be affected by small variations in the temporal determinants of cardiac cycle. [ABSTRACT FROM AUTHOR]- Published
- 2018
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- View/download PDF
4. Terapia antirretroviral altamente eficaz para infecção pelo vírus da imunodeficiência humana aumenta a rigidez aórtica
- Author
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Eira, Margareth, Bensenor, Isabela M., Dorea, Egidio Lima, Cunha, Roberto Sá, Mill, José Geraldo, and Lotufo, Paulo A.
- Subjects
Acquired Immunosyndrome ,Vascular Stiffness ,Rigidez Arterial ,Anti-Retrovirais ,Anti Retroviral Agents ,HIV Infections ,Síndrome de Imunodeficiência Adquirida ,Infecções por HIV - Abstract
FUNDAMENTO: Sabe-se que a terapia antirretroviral altamente potente para Aids reconhecida aumenta o risco cardiovascular, mas os efeitos dos agentes antirretrovirais de acordo com o gênero ainda são desconhecidos. OBJETIVO: O presente estudo avaliou o impacto do tratamento para o vírus da imunodeficiência humana (HIV) na rigidez aórtica de acordo com o gênero. MÉTODOS: Foram recrutados 28 pacientes com Aids submetidos à terapia antirretroviral altamente potente (HAART), 28 pacientes infectados pelo HIV virgens de tratamento, 44 pacientes com diabetes tipo 2, e 30 controles. A rigidez aórtica foi determinada pela medição da Velocidade da Onda de Pulso (VOP), utilizando um equipamento automático validado e não invasivo. RESULTADOS: Os resultados médios brutos da VOP (e intervalo de confiança de 95%) para participantes nos grupos terapia antirretroviral potente, HIV virgem de tratamento, diabéticos, e controles foram 9,77 m/s (9,17-10,36), 9,00 m/s (8,37-9,63), 9,90 m/s (9,32-10,49) e 9,28 m/s (8,61-9,95), respectivamente, para os homens (p de tendência = 0,14) e 9,61 m/s (8,56-10,66), 8,45 m/s (7,51-9,39), 9,83 (9,21-10,44) e 7,79 m/s (6,99-8,58), respectivamente, para as mulheres (p valor de tendência < 0,001). Análises post-hoc revelaram uma diferença significativa entre os valores médios de VOP no grupo com HAART e controles em mulheres (p < 0,01). Ajustes para as demais covariáveis potenciais, incluindo pressão arterial sistólica e diabetes, não alteraram esses resultados. Os achados indicam que o impacto do tratamento com HAART na rigidez aórtica foi amplificado nas mulheres com hipertensão, dislipidemia e síndrome metabólica. CONCLUSÃO: Agentes antirretrovirais potentes utilizados no tratamento da infecção pelo HIV aumentam a rigidez da aorta, especialmente em mulheres com maior risco cardiovascular. BACKGROUND: Highly active antiretroviral therapy for AIDS is known to increase cardiovascular risk, but the effects of potent antiretroviral agents according to gender are unknown. OBJECTIVE: The present study evaluated the impact of HIV infection treatment on aortic stiffness according to gender. METHODS: From university-affiliated hospitals, we recruited 28 AIDS patients undergoing highly active antiretroviral treatment (HAART), 28 treatment-naïve HIV-infected patients, 44 patients with type 2 diabetes, and 30 controls. Aortic stiffness was determined by measuring pulse wave velocity (PWV) using a validated and non-invasive automatic device. RESULTS: The crude mean PWV values and 95% confidence intervals (95% CI) for HAART, diabetics, and controls were 9.77 m/s (95% CI 9.17-10.36), , 9.00 m/s (95% CI 8.37-9.63), 9.90 m/s (95% CI 9.32-10.49), and 9.28 m/s (95% CI 8.61-9.95), respectively, for men (P-value for trend = 0.14), and 9.61 m/s (95% CI 8.56-10.66), 8.45 m/s (95% CI 7.51-9.39), 9.83 (95% CI 9.21-10.44), and 7.79 m/s (95% CI 6.99-8.58), respectively, for women (P-value for trend
- Published
- 2012
5. Terapia antirretroviral altamente eficaz para infecção pelo vírus da imunodeficiência humana aumenta a rigidez aórtica
- Author
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Eira, Margareth, primary, Bensenor, Isabela M., additional, Dorea, Egidio Lima, additional, Cunha, Roberto Sá, additional, Mill, José Geraldo, additional, and Lotufo, Paulo A., additional
- Published
- 2012
- Full Text
- View/download PDF
6. Higher Arterial Stiffness Predicts Chronic Kidney Disease in Adults: The ELSA-Brasil Cohort Study.
- Author
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Cândido J, Camelo LDV, Brant L, Cunha RS, Mill JG, and Barreto SM
- Subjects
- Adult, Female, Male, Humans, Cohort Studies, Longitudinal Studies, Pulse Wave Analysis, Vascular Stiffness, Renal Insufficiency, Chronic, Hypertension complications, Diabetes Mellitus
- Abstract
Background: Central Illustration : Higher Arterial Stiffness Predicts Chronic Kidney Disease in Adults: The ELSA-Brasil Cohort Study., Background: Arterial stiffening can directly affect the kidneys, which are passively perfused by a high flow. However, whether the relation between arterial stiffness and renal function depends on diabetes and hypertension conditions, is a matter of debate., Objective: To investigate the relationship between arterial stiffening by carotid-to-femoral pulse wave velocity (cfPWV) and chronic kidney disease (CKD) incidence in individuals and verify whether this association is present in individuals without hypertension and diabetes., Methods: A longitudinal study of 11,647 participants of the ELSA-Brasil followed up for four years (2008/10-2012/14). Baseline cfPWV was grouped per quartile, according to sex-specific cut-offs. Presence of CKD was ascertained by glomerular filtration rate (eGFR-CKD-EPI) < 60 ml/min/1.73 m2 and/or albumin-to-creatinine ratio ≥ 30 mg/g. Logistic regression models were run for the whole cohort and a subsample free from hypertension and diabetes at baseline, after adjustment for age, sex, race, schooling, smoking, cholesterol/HDL ratio, body mass index, diabetes, use of antihypertensive, systolic blood pressure, heart rate, and cardiovascular disease. Statistical significance was set at 5%., Results: The chance of CKD was 42% (CI 95%: 1.05;1.92) greater among individuals in the upper quartile of cfPWV. Among normotensive, non-diabetic participants, individuals in the 2nd, 3rd, and 4th quartiles of cfPWV presented greater chances of developing CKD, as compared to those in the lower quartile, and the magnitude of this association was the greatest for those in the upper quartile (OR: 1.81 CI 95%: 1.14;2.86)., Conclusion: Higher cfPWV increased the chances of CKD and suggests that this effect is even greater in individuals without diabetes and hypertension.
- Published
- 2024
- Full Text
- View/download PDF
7. Potent antiretroviral therapy for human immunodeficiency virus infection increases aortic stiffness.
- Author
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Eira M, Bensenor IM, Dorea EL, Cunha RS, Mill JG, and Lotufo PA
- Subjects
- Adult, Age Factors, Cardiovascular Diseases etiology, Chi-Square Distribution, Cross-Sectional Studies, Female, HIV Infections complications, Humans, Male, Middle Aged, Organ Size drug effects, Pulse Wave Analysis, Risk Factors, Sex Factors, Antiretroviral Therapy, Highly Active adverse effects, HIV Infections drug therapy, Vascular Stiffness drug effects
- Abstract
Background: Highly active antiretroviral therapy for AIDS is known to increase cardiovascular risk, but the effects of potent antiretroviral agents according to gender are unknown., Objective: The present study evaluated the impact of HIV infection treatment on aortic stiffness according to gender., Methods: From university-affiliated hospitals, we recruited 28 AIDS patients undergoing highly active antiretroviral treatment (HAART), 28 treatment-naïve HIV-infected patients, 44 patients with type 2 diabetes, and 30 controls. Aortic stiffness was determined by measuring pulse wave velocity (PWV) using a validated and non-invasive automatic device., Results: The crude mean PWV values and 95% confidence intervals (95% CI) for HAART, diabetics, and controls were 9.77 m/s (95% CI 9.17-10.36), , 9.00 m/s (95% CI 8.37-9.63), 9.90 m/s (95% CI 9.32-10.49), and 9.28 m/s (95% CI 8.61-9.95), respectively, for men (P-value for trend = 0.14), and 9.61 m/s (95% CI 8.56-10.66), 8.45 m/s (95% CI 7.51-9.39), 9.83 (95% CI 9.21-10.44), and 7.79 m/s (95% CI 6.99-8.58), respectively, for women (P-value for trend <0.001). Post-hoc analysis revealed a significant difference between the mean PWV values in the HAART group and controls in women (P-value <0.01). After adjusting for other potential covariates, including systolic blood pressure and diabetes, these results did not change. The findings indicate that the impact of HAART treatment on aortic stiffness was amplified in women with hypertension, dyslipidemia, and metabolic syndrome., Conclusion: Potent anti-retroviral agents used in the treatment of HIV infection increases aortic stiffness, mainly among women with higher cardiovascular risk.
- Published
- 2012
- Full Text
- View/download PDF
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