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The present study aims to investigate the psychological mechanisms behind the change in the facial expression of some of the beheaded characters in Caravaggio’s works, starting from The Head of Medusa, from the artist’s youth, and up to David with the Head of Goliath, a mature workpiece, searching the continuity between them through a series of self‑portraits/ self‑insertions of the artist in his work. The psychodynamic analysis I propose is limited by the constitution of its practice to the study of the process of image production and the artistic imaginary, rather than to the investigation of the man or the artist, who is out of reach, by means of figurative and symbolic language. This approach aims to highlight the drives of the unconscious, the structures of censorship and the operating technique of the defensive mechanisms that ultimately could contribute to the production of such masterful images that are both seductive and confusing. The study incorporates and continues the contribution of authors such as Leo Bersani and Ulysse Dutoit, who applied Laplanche’s theory of generalized seduction in the analysis of Caravaggio’s works, but also the mirror stage of Lacan and the masterful study of Donald Winnicott regarding the reflection of the baby in the mimics of his mother, an unconscious unclear image that will stand forever for the perception of the self. The change of the affective resonance, expressiveness and emotional relating to violence is natural in the course of human evolution. While not even the artist Caravaggio can elude it, his work can illus‑ trate by deflection these transformations of the dynamics of the mind, it can raise new questions and open new perspectives of understanding the artistic drive. [ABSTRACT FROM AUTHOR]

Introduction The aim of the study was to assess the safety and efficacy of darunavir (Prezista®) used in subtype F human immunodeficiency virus – type 1 (HIV-1) infected, antiretroviral therapy (ART)-experienced patients in Romania in routine clinical practice. Methods This was a post-authorization, open-label, one-cohort, non-interventional, prospective study conducted at multiple sites in Romania to assess efficacy (CD4 cell count, viral load, and treatment compliance) and safety ([serious] adverse events, clinical laboratory evaluation, and vital signs) of darunavir in combination with low-dose ritonavir (DRV/r) and other antiretroviral (ARV) medications in subtype F HIV-1 infected subjects in naturalistic settings. Seventy-eight subjects were recruited by 9 investigational sites and received 600/100 mg DRV/r twice daily. Results Treatment with DRV/r administered with other ARV medications resulted in the expected, statistically relevant improvement of CD4 cell count and viral load in subjects eligible for such treatment. In addition, adherence to treatment was high and the treatment-emergent safety profile observed during this study was consistent with the established safety profile of darunavir. Conclusion DRV/r administered in combination with other ARV medications in subtype F HIV-1 infected subjects in naturalistic settings proved to be an effective and safe treatment in Romania. [ABSTRACT FROM AUTHOR]