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7. Use of the International Classification of Functioning, Disability and Health Generic-30 Set for the characterization of outpatients: Italian Society of Physical and Rehabilitative Medicine Residents Section Project

Author

Gimigliano, F., de Sire, A., Gastaldo, M., Maghini, I., Paoletta, M., Pasquini, A., Boldrini, P., Selb, M., Prodinger, B., Abbamonte, M., Alito, A., Amico, I., Armiento, R., Asaro, C., Balsamo, F., Bakdounes, L., Barak, M., Bartolini, V., Bartolo, D., Battista, A., Beatrice, R., Bianchito, R., Bonjako, M., Bossi, D., Cameli, C., Camerlingo, A., Capponi, R., Caspani, P., Cecini, M., Chiarici, A., Ci-None, N., Costanza, C., Covella, E., Culmone, F., Curci, C., Dagna, C., Denisi, A., Del Puente, A., D'Esposito, O., Di Gianni, L., Esposto, C., Fazio, R., Finocchiaro, A., Forestiere, G., Galletti, L., Gariboldi, V., Garoia, B., Gentile, L., Giambelluca, E., Ginelli, E., Giovannucci, M., Iamele, G., Latini, L., Letizia, S., Liguori, S., Limonta, M., Machi, M., Maestri, G., Manca, M., Mandrini, S., Mantovani, M. E., Maracci, F., Mariani, F., Mazzola, A., Mazzuoccolo, G., Monteleone, S., Muscari, S., Parodi, G., Pedrini, M., Pellegrino, G., Picone, A., Poletti, M., Postorio, D., Raiano, E., Ribaudo, F., Rinaldi, M., Ruggeri, J., Russo, F., Sama, L., Sanavia, L., Sannia, E., Santoro, L., Sega, L., Siani, M. F., Sigismondi, E., Spaziante, L., Spicuglia, A., Stefano, L., Surcinelli, A., Togni, R., Toniazzo, S., Tumminelli, L., Virelli, L., Wolenski, V., Zandalasini, M., Zannino, A., Gimigliano, F., Sire, De, Gastaldo, A., Maghini, M., Paoletta, I., Pasquini, M., Boldrini, A., Selb, P., Prodinger, M., Abbamonte, B., Alito, M., Amico, A., Armiento, I., Asaro, R., Balsamo, C., Bakdounes, F., Barak, L., Bartolini, M., Bartolo, V., Battista, D., Beatrice, A., Bianchito, R., Bonjako, R., Bossi, M., Cameli, D., Camerlingo, C., Capponi, A., Caspani, R., Cecini, P., Chiarici, M., Ci-None, A., Costanza, N., Covella, C., Culmone, E., Curci, F., Dagna, C., Denisi, C., Del, Puente, D’Esposito, A., Gianni, Di, Esposto, L., Fazio, C., Finocchiaro, R., Forestiere, A., Galletti, G., Gariboldi, L., Garoia, V., Gentile, B., Giambelluca, L., Ginelli, E., Giovannucci, E., Iamele, M., Latini, G., Letizia, L., Liguori, S., Limonta, S., Machì, M., Maestri, M., Manca, G., Mandrini, M., Mantovani, S., Maracci, M. E., Mariani, F., Mazzola, F., Mazzuoccolo, A., Monteleone, G., Muscari, S., Parodi, S., Pedrini, G., Pellegrino, M., Picone, G., Poletti, A., Postorio, M., Raiano, D., Ribaudo, E., Rinaldi, F., Ruggeri, M., Russo, J., Samà, F., Sanavia, L., Sannia, L., Santoro, E., Sega, L., Siani, L., Sigismondi, M. F., Spaziante, E., Spicuglia, L., Stefano, A., Surcinelli, L., Togni, A., Toniazzo, R., Tumminelli, S., Virelli, L., Wolenski, L., Zandalasini, V., Zannino, M., and SIMFER Residents Section Group

Subjects
Male, 030506 rehabilitation, medicine.medical_specialty, Health information systems, Cross-sectional study, medicine.medical_treatment, Population, MEDLINE, Physical Therapy, Sports Therapy and Rehabilitation, International Classification of Functioning, Education, 03 medical and health sciences, 0302 clinical medicine, International Classification of Functioning, Disability and Health, Medical, Outpatients, Health information system, Numeric Rating Scale, Medicine, Humans, Graduate, education, Set (psychology), Health plan implementation, education.field_of_study, Disability, Data collection, Rehabilitation, business.industry, Internship and Residency, Middle Aged, Physical and Rehabilitation Medicine, humanities, Health, Cross-Sectional Studies, Female, Italy, Education, Medical, Graduate, Family medicine, Disability and Health, 0305 other medical science, business, human activities, 030217 neurology & neurosurgery
Abstract

BACKGROUND: The International Classification of Functioning, Disability and Health (ICF) Generic-30 Set (previously referred to as Rehabilitation Set) is a minimal set of ICF categories for reporting and assessing functioning and disability in clinical populations with different health conditions along the continuum of care. Recently, the Italian Society of Physical and Rehabilitation Medicine (SIMFER) developed an Italian modification of the simple and intuitive descriptions (SID) of these categories. This study was the first one to implement the use of the SID in practice. AIM: The main aims of this study are: 1) to implement the use of the ICF in clinical practice and research among Italian Residents in PRM, and 2) to verify if the SID made the application of ICF Generic 30 Set more user-friendly than the original descriptions; 3) to examine the prevalence of functioning problems of patients accessing Rehabilitation Services to serve as reference for the development of an ICF-based clinical data collection tool. DESIGN: Multicenter cross-sectional study. SETTING: Italian Physical Medicine and Rehabilitation (PRM) outpatient rehabilitation services. POPULATION: Patients referring to Italian PRM outpatient rehabilitation services and Italian Residents in PRM. METHODS: Each School of Specialization involved, randomly, received the ICF Generic-30 Set with the original descriptions or with the SID. Residents collected over a 4-month period (April-July 2016) patients data related to the ICF Generic-30 Set categories. Moreover, the residents self-assessed their difficulty in using the ICF Generic-30 Set with the original descriptions or with the SID, through a Numeric Rating Scale (NRS). RESULTS: Ninety-three residents collected functioning data of 864 patients (mean aged 57.7±19.3) with ICF Generic-30 Set: 304 with the original descriptions and 560 with SID. The difficulty in using the ICF Generic-30 Set with SID was rated as lower than using the original descriptions (NRS 2.8±2.5 vs. 3.5±3.1; P

Published
2018

9. LA CARATTERIZZAZIONE DEI DISTURBI DEL SONNO NEI PAZIENTI CON STROKE CRONICO: STUDIO DI COORTE

Author

Giamattei M.T., Curci C., Moretti A, Gimigliano F., Iolascon G., Giamattei, M. T., Curci, C., Moretti, A, Gimigliano, F., and Iolascon, G.

Abstract

L’outcome clinico-funzionale dei pazienti con esiti di ictus è condizionato dalla presenza di diversi fattori interagenti. È stato ipotizzato che la presenza di disturbi del sonno possa incidere in maniera significativa su alcuni parametri funzionali in questi pazienti. Le alterazioni del pattern del sonno sono presenti fino al 70% dei soggetti con stroke acuto. In particolare, frequenti sono la riduzione del tempo del sonno totale, dell'efficienza del sonno e un aumento del numero dei risvegli. Inoltre, l’architettura del sonno sembrerebbe modificarsi a favore di una riduzione delle fasi REM, NREM2 e NREM3 e di un prolungamento della fase NREM1. Fino al 50% degli individui con esiti di stroke sperimentano un disturbo del sonno, anche se le alterazioni dell’architettura del sonno in questi pazienti non sono state ben caratterizzate. L’obiettivo del nostro studio è valutare parametri soggettivi e oggettivi del profilo del sonno in una coorte di pazienti affetti da stroke cronico. Abbiamo condotto uno studio osservazionale trasversale in una coorte di pazienti affetti da stroke cronico (almeno 12 mesi dall’evento acuto), di entrambi i sessi, in assenza di accidenti cerebrovascolari precedenti e di disturbi cognitivi (score di almeno 24 al Mini–Mental State Examination) e con uno score motorio alla Functional Indipendence Measure (FIM) ≥13. I criteri di esclusione sono stati: presenza di altre significative patologie in fase acuta, sindrome delle apnee ostruttive nel sonno (OSAS) e storia di disturbi psicotici. A tutti i partecipanti allo studio è stata somministrata una scheda valutativa comprendente dati anagrafici e antropometrici (età, peso e altezza), la scala Cumulative Illness Rating Scale (CIRS) per la valutazione delle comorbidità, la Stroke Impact Scale (SIS) per la valutazione della severità dello stroke in fase cronica e la FIM. Per la valutazione soggettiva del sonno nell’ultimo mese, ai pazienti è stata somministrato il Pittsburgh Sleep Quality Index (PSQI). Per la valutazione del tono dell’umore è stata usata la Hamilton Depression Rating Scale (HAM-D), per valutare dolore e qualità di vita (HRQoL) sono state usate rispettivamente la Brief Pain Inventory (BPI), la SF-12 e l’EQ-5D-3L. La valutazione oggettiva degli aspetti qualitativi e quantitativi del sonno è stata eseguita utilizzando lo X4 Sleep Profiler™ In-Home EEG Sleep Monitor – Advanced e misurando i seguenti parametri: Sleep Time, Sleep Efficiency, durata dello Stadio Rem, N1-N2-N3, Cortical Arousal, Awakening, Rem Latency, Wake Sleep After Onset (WASO) e Sleep Latency confrontati con i valori normali indicati dallo strumento. La nostra popolazione è di 7 pazienti, 2 maschi e 5 femmine, con età media di 69,3±13,6 anni. La valutazione delle comorbidità ha evidenziato un CIRS Severity index medio di 1,85 e un CIRS Comorbidity index medio di 4,43. La valutazione della SIS ha evidenziato impairment significativi in tutti gli item. La valutazione della autonomia funzionale ha mostrato un valore medio di FIM di 39 a fronte di un livello di outcome motorio di riferimento di 55,9. Lo score medio del Pittsburgh Sleep Quality Index era di 11,14, indicativo di scarsa qualità del sonno. La valutazione della HRQoL evidenzia un’alterata percezione dello stato di salute (EQ-5D-3L index medio 0,28), in particolare della componente fisica (SF12 PCS medio 24,2) piuttosto che di quella psicologica (SF12 MCS medio 34,2). Il BPI ha mostrato un’ interferenza del dolore con le ADL di grado moderato (BPI Interference Index medio 6,63). L’HAM-D ha mostrato uno score medio di 16,3 compatibile con uno stato di depressione lieve. La misurazione dei parametri del sonno ha mostrato una alterazione della architettura del sonno in termini di riduzione del tempo totale e della Sleep Efficiency. È stata evidenziata una riduzione media della durata dello stadio NREM3 ed un aumento della durata degli stadi NREM1 e NREM2, senza alterazioni della durata del sonno REM; inoltre risultavano aumentati il numero di risvegli e i Cortical Arousals (Tabella 1). Nella nostra coorte l’architettura del sonno risulta essere alterata sia dal punto di vista strumentale che self-reported. I disturbi del sonno rappresentano un outcome importante da valutare nei pazienti con stroke cronico e l’utilizzo di metodiche strumentali non invasive potrebbe essere un approccio utile e di facile applicabilità.

Published
2016

11. SaO053ADULT RENAL STEM/PROGENITOR CELLS (ARPCS) HAVE AN IMMUNOMODULATORY EFFECT ON T REGULATORY CELLS (TREGS) AND DOUBLE NEGATIVE (DN) T CELLS

Author

Curci, C, primary, Chaoul, N, additional, Picerno, A, additional, De Palma, G, additional, Laghetti, P, additional, Stasi, A, additional, Franzin, R, additional, Rutigliano, M, additional, Lucarelli, G, additional, Battaglia, M, additional, Pertosa, G b, additional, Gallone, A, additional, Castellano, G, additional, Gesualdo, L, additional, and Sallustio, F, additional

Published
2018
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12. FP211A CLUSTER OF PROTEINS SECRETED BY HUMAN RENAL STEM/PROGENITOR CELLS (ARPCS) PROVIDE A NOVEL STRATEGY TO REVERT ENDOTHELIAL DYSFUNCTION AND RENAL INJURY IN SEPSIS-INDUCED ACUTE KIDNEY INJURY (AKI)

Author

Sallustio, F, primary, Stasi, A, additional, Curci, C, additional, Franzin, R, additional, Picerno, A, additional, Divella, C, additional, Laghetti, P, additional, De Palma, G, additional, Accetturo, M, additional, Rutigliano, M, additional, Lucarelli, G, additional, Battaglia, M, additional, Pertosa, G B, additional, Gallone, A, additional, Gesualdo, L, additional, and Castellano, G, additional

Published
2018
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13. FP025THE ROLE OF LONG NON-CODING RNAS IN THE REGULATION OF ADULT RENAL STEM/PROGENITOR CELLS (ARPCS) FUNCTIONS

Author

Simone, S, primary, De Palma, G, additional, Stasi, A, additional, Curci, C, additional, Franzin, R, additional, Accetturo, M, additional, Rutigliano, M, additional, Lucarelli, G, additional, Battaglia, M, additional, Gallone, A, additional, Grandaliano, G, additional, Castellano, G, additional, Gesualdo, L, additional, Pertosa, Giovanni, additional, and Sallustio, F, additional

Published
2018
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14. Renal fibrosis and anemia: an history to be discovered

Author

Curci, C., Castellano, G., Curci, C., and Castellano, G.

Abstract

The real origin of fibroblast during the development of renal fibrosis is still uncertain. In a recent paper by Asada and colleagues the Authors demonstrated that the majority of Erythropoietin-producing fibroblasts in the healthy kidney originate from myelin-positive extra renal cells. During the development of renal fibrosis, these extrarenal fibroblast trans-differentiated into myofibroblasts with concomitant loss of erythropoietin production. These intriguing data might lead to the development of new drugs both capable to reduce renal fibrosis and preserve the production of endogenous Erythropoietin., Ad oggi l'origine dei fibroblasti, le principali cellule responsabili dello sviluppo della fibrosi renale, è ancora incerta. In un recente lavoro pubblicato da Asada e colleghi, gli Autori dimostrano che la maggior parte dei fibroblasti secernenti eritropoietina nel rene normale hanno un'origine extra renale e provengono da cellule della Cresta Neurale. Durante lo sviluppo della fibrosi renale, queste cellule trans-differenziano in miofibroblasti, perdendo la loro capacità intrinseca di produrre eritropoietina. Questi interessanti dati potrebbero rappresentare il punto di partenza per lo sviluppo di nuovi farmaci capaci da un lato di ridurre la fibrosi renale e dall'altro di preservare la produzione di eritropoietina.

Published
2018

17. Endothelial-to-mesenchymal transition and renal fibrosis in ischaemia/reperfusion injury are mediated by complement anaphylatoxins and Akt pathway

Author

Curci, C., primary, Castellano, G., additional, Stasi, A., additional, Divella, C., additional, Loverre, A., additional, Gigante, M., additional, Simone, S., additional, Cariello, M., additional, Montinaro, V., additional, Lucarelli, G., additional, Ditonno, P., additional, Battaglia, M., additional, Crovace, A., additional, Staffieri, F., additional, Oortwijn, B., additional, van Amersfoort, E., additional, Gesualdo, L., additional, and Grandaliano, G., additional

Published
2014
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18. Cell signalling

Author

Tsuchiya, K., primary, Shiohira, S., additional, Sugiura, H., additional, Suzuki, M., additional, Okano, K., additional, Nitta, K., additional, Kaesler, N., additional, Immendorf, S., additional, Ouyang, C., additional, Carmeliet, P., additional, Floege, J., additional, Kruger, T., additional, Schlieper, G., additional, Georgescu, A., additional, Kalucka, J., additional, Olbrich, S., additional, Baumgartl, J., additional, Hackenbeck, T., additional, Eckardt, K.-U., additional, Weidemann, A., additional, Chmielewski, S., additional, Olejnik, A., additional, Sikorski, K., additional, Heemann, U., additional, Wesoly, J., additional, Bluyssen, H., additional, Baumann, M., additional, Mekahli, D., additional, Decuypere, J.-P., additional, Missiaen, L., additional, Levtchenko, E., additional, De Smedt, H., additional, Stasi, A., additional, Castellano, G., additional, Gigante, M., additional, Intini, A., additional, Pontrelli, P., additional, Divella, C., additional, Curci, C., additional, Grandaliano, G., additional, Gesualdo, L., additional, Vizza, D., additional, Perri, A., additional, Lofaro, D., additional, Toteda, P., additional, Lupinacci, S., additional, Leone, F., additional, Gigliotti, P., additional, Papalia, T., additional, Bonofiglio, R., additional, Vatazin, A. V., additional, Astakhov, P. V., additional, Zulkarnaev, A. B., additional, Parodi, E., additional, Verzola, D., additional, D'Amato, E., additional, Viazzi, F., additional, Gonnella, A., additional, Garneri, D., additional, Pontremoli, R., additional, Garibotto, G., additional, Chen, T.-H., additional, Chen, C.-H., additional, Chen, Y.-C., additional, Sue, Y.-M., additional, Cheng, C.-Y., additional, Guiying, L., additional, Ying, L., additional, Pozzoli, S., additional, Lino, M., additional, Delli Carpini, S., additional, Ferrandi, M., additional, Zerbini, G., additional, Simonini, M., additional, Zagato, L., additional, Molinari, I., additional, Citterio, L., additional, Manunta, P., additional, Feng, X., additional, Pan, X., additional, Wang, W., additional, Chen, N., additional, Chen, Y.-x., additional, Wang, W.-M., additional, Tanaka, S., additional, Yano, S., additional, Sugimoto, T., additional, Noh, H., additional, Yu, M. R., additional, Kim, H. J., additional, Woo, S. A., additional, Cho, Y. J., additional, Kwon, S. H., additional, Jeon, J. S., additional, Han, D. C., additional, Shimizu, H., additional, Yisireyili, M., additional, Nishijima, F., additional, Niwa, T., additional, Koh, E. S., additional, Chung, S., additional, Kim, S. J., additional, Yoon, H. E., additional, Park, C. W., additional, Chang, Y. S., additional, Shin, S. J., additional, Seong, E. Y., additional, Rhee, H., additional, Shin, M. J., additional, Yang, B. Y., additional, Jung, Y. S., additional, Lee, D. W., additional, Lee, S. B., additional, Kwak, I. S., additional, Kim, I. Y., additional, Sancho-Martinez, S. M., additional, Prieto-Garcia, L., additional, Lopez-Hernandez, F. J., additional, Lopez-Novoa, J. M., additional, Bae, E. H., additional, Choi, H. S., additional, Joo, S. Y., additional, Kim, I. J., additional, Kim, C. S., additional, Choi, J. S., additional, Ma, S. K., additional, Lee, J., additional, Kim, S. W., additional, Humanes, B., additional, Sonia, C., additional, Jado, J., additional, Mojena, M., additional, Lara, J., additional, Alvarez-Sala, L., additional, Tejedor, A., additional, Lazaro, A., additional, Wada, Y., additional, Iyoda, M., additional, Matsumoto, K., additional, Shindo-Hirai, Y., additional, Kuno, Y., additional, Yamamoto, Y., additional, Suzuki, T., additional, Shibata, T., additional, Akizawa, T., additional, Faubel, S., additional, Edelstein, C. L., additional, Cano Penalver, J. L., additional, de Frutos Garcia, S., additional, Griera Merino, M., additional, Luengo Rodriguez, A., additional, Garcia Jerez, A., additional, Bohorquez Magro, L., additional, Medrano, D., additional, Calleros Basilio, L., additional, Rodriguez Puyol, M., additional, Thilo, F., additional, Liu, Y., additional, Tepel, M., additional, Hsu, H.-H., additional, Chen, K.-H., additional, Hung, C.-C., additional, Yang, C.-W., additional, Endlich, N., additional, Lin, J.-L., additional, Pavenstadt, H., additional, Rodrigues Diez, R. R., additional, Mezzano, S., additional, Ruiz-Ortega, M., additional, Rodrigues Diez, R., additional, Lavoz, C., additional, Nakayama, Y., additional, Fukami, K., additional, Yamagishi, S.-i., additional, Obara, N., additional, Yokoro, M., additional, Ando, R., additional, Kaida, Y., additional, Toyonaga, M., additional, Kaifu, K., additional, Takeuchi, M., additional, Ueda, S., additional, Okuda, S., additional, Daenen, K., additional, Hoylaerts, M. F., additional, Bammens, B., additional, Liu, J., additional, Zhong, F., additional, Dai, Q., additional, Xu, L., additional, Zaravinos, A., additional, and Deltas, C. C., additional

Published
2013
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19. Genetic diseases and molecular genetics

Author

Legendre, C., primary, Cohen, D., additional, Delmas, Y., additional, Feldkamp, T., additional, Fouque, D., additional, Furman, R., additional, Gaber, O., additional, Greenbaum, L., additional, Goodship, T., additional, Haller, H., additional, Herthelius, M., additional, Hourmant, M., additional, Licht, C., additional, Moulin, B., additional, Sheerin, N., additional, Trivelli, A., additional, Bedrosian, C. L., additional, Loirat, C., additional, Legendre, C., additional, Babu, S., additional, Jungraithmayr, T., additional, Lebranchu, Y., additional, Riedl, M., additional, Gaber, A. O., additional, Bedrosian, C., additional, Muus, P., additional, Douglas, K., additional, Remuzzi, G., additional, Kourouklaris, A., additional, Ioannou, K., additional, Athanasiou, I., additional, Demetriou, K., additional, Panagidou, A., additional, Zavros, M., additional, Rodriguez C, N. Y., additional, Blasco, M., additional, Arcal, C., additional, Quintana, L. F., additional, Rodriguez de Cordoba, S., additional, Campistol, J. M., additional, Bachmann, N., additional, Eisenberger, T., additional, Decker, C., additional, Bolz, H. J., additional, Bergmann, C., additional, Pesce, F., additional, Cox, S. N., additional, Serino, G., additional, De Palma, G., additional, Sallustio, F. P., additional, Schena, F., additional, Falchi, M., additional, Pieri, M., additional, Stefanou, C., additional, Zaravinos, A., additional, Erguler, K., additional, Lapathitis, G., additional, Dweep, H., additional, Sticht, C., additional, Anastasiadou, N., additional, Zouvani, I., additional, Voskarides, K., additional, Gretz, N., additional, Deltas, C. C., additional, Ruiz, A., additional, Bonny, O., additional, Sallustio, F., additional, Curci, C., additional, Cox, S., additional, Kemter, E., additional, Sklenak, S., additional, Aigner, B., additional, Wanke, R., additional, Kitzler, T. M., additional, Moskowitz, J. L., additional, Piret, S. E., additional, Lhotta, K., additional, Tashman, A., additional, Velez, E., additional, Thakker, R. V., additional, Kotanko, P., additional, Leierer, J., additional, Rudnicki, M., additional, Perco, P., additional, Koppelstaetter, C., additional, Mayer, G., additional, Sa, M. J. N., additional, Alves, S., additional, Storey, H., additional, Flinter, F., additional, Willems, P. J., additional, Carvalho, F., additional, Oliveira, J., additional, Arsali, M., additional, Papazachariou, L., additional, Demosthenous, P., additional, Lazarou, A., additional, Hadjigavriel, M., additional, Stavrou, C., additional, Yioukkas, L., additional, Deltas, C., additional, Pierides, A., additional, Kkolou, M., additional, Toka, H. R., additional, Dibartolo, S., additional, Lanske, B., additional, Brown, E. M., additional, Pollak, M. R., additional, Familiari, A., additional, Zavan, B., additional, Sanna Cherchi, S., additional, Fabris, A., additional, Cristofaro, R., additional, Gambaro, G., additional, D'Angelo, A., additional, Anglani, F., additional, Toka, H., additional, Mount, D., additional, Pollak, M., additional, Curhan, G., additional, Sengoge, G., additional, Bajari, T., additional, Kupczok, A., additional, von Haeseler, A., additional, Schuster, M., additional, Pfaller, W., additional, Jennings, P., additional, Weltermann, A., additional, Blake, S., additional, Sunder-Plassmann, G., additional, Kerti, A., additional, Csohany, R., additional, Wagner, L., additional, Javorszky, E., additional, Maka, E., additional, Tulassay, T., additional, Tory, K., additional, Kingswood, J., additional, Nikolskaya, N., additional, Mbundi, J., additional, Jozwiak, S., additional, Belousova, E., additional, Frost, M., additional, Kuperman, R., additional, Bebin, M., additional, Korf, B., additional, Flamini, R., additional, Kohrman, M., additional, Sparagana, S., additional, Wu, J., additional, Brechenmacher, T., additional, Stein, K., additional, Bissler, J., additional, Franz, D., additional, Zonnenberg, B., additional, Cheung, W., additional, Wang, J., additional, Lam, D., additional, Budde, K., additional, Ivanitskiy, L., additional, Sowershaewa, E., additional, Krasnova, T., additional, Samokhodskaya, L., additional, Safarikova, M., additional, Jana, R., additional, Jitka, S., additional, Obeidova, L., additional, Kohoutova, M., additional, Tesar, V., additional, Evrengul, H., additional, Ertan, P., additional, Serdaroglu, E., additional, Yuksel, S., additional, Mir, S., additional, Yang n Ergon, E., additional, Berdeli, A., additional, Zawada, A., additional, Rogacev, K., additional, Rotter, B., additional, Winter, P., additional, Fliser, D., additional, Heine, G., additional, Bataille, S., additional, Moal, V., additional, Berland, Y., additional, Daniel, L., additional, Rosado, C., additional, Bueno, E., additional, Fraile, P., additional, Lucas, C., additional, Garcoa-Cosmes, P., additional, Tabernero, J. M., additional, Gonzalez, R., additional, Garcia-Cosmes, P., additional, Silska-Dittmar, M., additional, Zaorska, K., additional, Malke, A., additional, Musielak, A., additional, Ostalska-Nowicka, D., additional, Zachwieja, J., additional, K d r, V., additional, Uz, E., additional, Yigit, A., additional, Altuntas, A., additional, Yigit, B., additional, Inal, S., additional, Sezer, M., additional, Yilmaz, R., additional, Visciano, B., additional, Porto, C., additional, Acampora, E., additional, Russo, R., additional, Riccio, E., additional, Capuano, I., additional, Parenti, G., additional, Pisani, A., additional, Feriozzi, S., additional, Perrin, A., additional, West, M., additional, Nicholls, K., additional, Torras, J., additional, Cybulla, M., additional, Conti, M., additional, Angioi, A., additional, Floris, M., additional, Melis, P., additional, Asunis, A. M., additional, Piras, D., additional, Pani, A., additional, Warnock, D., additional, Guasch, A., additional, Thomas, C., additional, Wanner, C., additional, Campbell, R., additional, Vujkovac, B., additional, Okur, I., additional, Biberoglu, G., additional, Ezgu, F., additional, Tumer, L., additional, Hasanoglu, A., additional, Bicik, Z., additional, Akin, Y., additional, Mumcuoglu, M., additional, Ecder, T., additional, Paliouras, C., additional, Mattas, G., additional, Papagiannis, N., additional, Ntetskas, G., additional, Lamprianou, F., additional, Karvouniaris, N., additional, and Alivanis, P., additional

Published
2013
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20. AKI - experimental models

Author

Lai, C.-F., primary, Lin, S.-L., additional, Chiang, W.-C., additional, Chen, Y.-M., additional, Kuo, M.-L., additional, Tsai, T.-J., additional, Hwang, H. S., additional, Choi, Y. A., additional, Park, K. C., additional, Yang, K. J., additional, Choi, H. S., additional, Kim, S. H., additional, Lee, S. J., additional, Chang, Y. K., additional, Kim, S. Y., additional, Yang, C. W., additional, Xiujuan, Z., additional, Yoshimura, R., additional, Matsuyama, M., additional, Chargui, J., additional, Touraine, J.-L., additional, Yoshimura, N., additional, Zulkarnaev, A. B., additional, Vasilenko, I. A., additional, Artemov, D. V., additional, Vatazin, A. V., additional, Park, S. K., additional, Kang, K. P., additional, Lee, S., additional, Kim, W., additional, Schneider, R., additional, Betz, B., additional, Moller-Ehrlich, K., additional, Wanner, C., additional, Sauvant, C., additional, Park, C. W., additional, Sohotnik, R., additional, Nativ, O., additional, Abbasi, A., additional, Awad, H., additional, Frajewicki, V., additional, Armaly, Z., additional, Heyman, S. N., additional, Abassi, Z., additional, Chen, P. Y., additional, Chen, B. L., additional, Yang, C. C., additional, Chiang, C. K., additional, Liu, S. H., additional, Abozahra, A. E., additional, Abd-Elkhabir, A. A., additional, Shokeir, A., additional, Hussein, A., additional, Awadalla, A., additional, Barakat, N., additional, Abdelaziz, A., additional, Yamaguchi, J., additional, Tanaka, T., additional, Eto, N., additional, Nangaku, M., additional, Quiros, Y., additional, Lopez-Hernandez, F. J., additional, Perez de Obanos, M. P., additional, Ruiz, J., additional, Lopez-Novoa, J. M., additional, Shin, H.-S., additional, Kim, M.-J., additional, Choi, Y.-J., additional, Ryu, E.-S., additional, Choi, H.-S., additional, Kang, D.-H., additional, Jankauskas, S. S., additional, Pevzner, I. B., additional, Zorova, L. D., additional, Babenko, V. A., additional, Morosanova, M. A., additional, Plotnikov, E. Y., additional, Zorov, D. B., additional, Huang, C.-Y., additional, Huang, T.-M., additional, Wu, V.-C., additional, Young, G.-H., additional, Chupyrkina, A. A., additional, Zorov, S. D., additional, Grande, J. P., additional, Hartono, S. P., additional, Knudsen, B. E., additional, Mederle, K., additional, Castrop, H., additional, Hocherl, K., additional, Iwakura, T., additional, Fujikura, T., additional, Ohashi, N., additional, Yasuda, H., additional, Fujigaki, Y., additional, Matsui, I., additional, Hamano, T., additional, Inoue, K., additional, Obi, Y., additional, Nakano, C., additional, Kusunoki, Y., additional, Tsubakihara, Y., additional, Rakugi, H., additional, Isaka, Y., additional, Shimomura, A., additional, Wallentin Guron, C., additional, Nguy, L., additional, Lundgren, J., additional, Grimberg, E., additional, Kashioulis, P., additional, Guron, G., additional, DiBona, G. F., additional, Nedergaard Mikkelsen, M., additional, Marcussen, N., additional, Saeed, A., additional, Edvardsson, K., additional, Lindberg, K., additional, Larsson, T., additional, Ito, K., additional, Nakashima, H., additional, Watanabe, M., additional, Abe, Y., additional, Ogahara, S., additional, Saito, T., additional, Albertoni, G., additional, Borges, F., additional, Schor, N., additional, Beresneva, O. N., additional, Parastayeva, M. M., additional, Kucher, A. G., additional, Ivanova, G. T., additional, Shved, N., additional, Rybakova, M. G., additional, Kayukov, I. G., additional, Smirnov, A. V., additional, Chen, J.-F., additional, Ni, H.-F., additional, Pan, M.-M., additional, Liu, H., additional, Xu, M., additional, Zhang, M.-H., additional, Liu, B.-C., additional, Kim, Y., additional, Choi, B. S., additional, Kim, Y. S., additional, Han, J. S., additional, Reis, L. A., additional, Christo, J. S., additional, Simoes, M. d. J., additional, Mulay, S. R., additional, Santhosh Kumar, V. R., additional, Kulkarni, O. P., additional, Darisipudi, M., additional, Lech, M., additional, Anders, H.-J., additional, Silachev, D. N., additional, Sola, A., additional, Jung, M., additional, Ventayol, M., additional, Mastora, C., additional, Buenestado, S., additional, Hotter, G., additional, Rong, S., additional, Shushakova, N., additional, Wensvoort, G., additional, Haller, H., additional, Gueler, F., additional, Morais, C., additional, Vesey, D. A., additional, Johnson, D. W., additional, Gobe, G. C., additional, Godo, M., additional, Kaucsar, T., additional, Revesz, C., additional, Hamar, P., additional, Cheng, Q., additional, Wen, J., additional, Ma, Q., additional, Zhao, J., additional, Castellano, G., additional, Stasi, A., additional, Di Palma, A. M., additional, Gigante, M., additional, Netti, G. S., additional, Curci, C., additional, Intini, A., additional, Divella, C., additional, Prattichizzo, C., additional, Fiaccadori, E., additional, Pertosa, G., additional, Grandaliano, G., additional, Gesualdo, L., additional, Wei, Q. W., additional, Jing, Q. Q., additional, Ying, N. J., additional, Dong, Q. Z., additional, Yong, G., additional, Pulkova, N. V., additional, Sukhikh, G. T., additional, Kim, S., additional, Lee, J., additional, Nam, N. J., additional, Na, K. Y., additional, Ma, S. K., additional, Joo, S. Y., additional, Kim, C. S., additional, Choi, J. S., additional, Bae, E. H., additional, Kim, S. W., additional, Cernaro, V., additional, Medici, M. A., additional, Donato, V., additional, Trimboli, D., additional, Lorenzano, G., additional, Santoro, D., additional, Montalto, G., additional, Buemi, M., additional, Longo, V., additional, Segreto, H. R. C., additional, Almeida, W., additional, Ramos, M. F., additional, Gomes, L., additional, Razvickas, C., additional, Gutberlet, M., additional, Meier, M., additional, Mengel, M., additional, Wacker, D., additional, Hueper, K., additional, Uzum, A., additional, Ersoy, R., additional, Cakalagaoglu, F., additional, Karaman, M., additional, Kolatan, E., additional, Sahin, O., additional, Yilmaz, O., additional, Cirit, M., additional, Inal, S., additional, Koc, E., additional, Okyay, G. U., additional, Pasaoglu, O., additional, Gonul, I., additional, Oyar, E., additional, Pasaoglu, H., additional, Guz, G., additional, Sabbatini, M., additional, Rossano, R., additional, Andreucci, M., additional, Pisani, A., additional, Riccio, E., additional, Choi, D. E., additional, Jeong, J. Y., additional, Kim, S. S., additional, Na, K.-R., additional, Lee, K. W., additional, Shin, Y. T., additional, Silva, A. F., additional, Teixeira, V. C., additional, Meszaros, K., additional, Koleganova-Gut, N., additional, Schaefer, F., additional, Ritz, E., additional, Walacides, D., additional, Ruskamp, N., additional, Schiffer, M., additional, Marom, O., additional, Haick, H., additional, Nakhoul, F., additional, Lv, L.-L., additional, Tang, R.-N., additional, Zhang, J.-D., additional, Ma, K.-L., additional, Chen, P.-S., additional, Ko, W.-J., additional, Misiara, G. P., additional, Coimbra, T. M., additional, Silva, G. E. B., additional, Costa, R. S., additional, Francescato, H. D. C., additional, Neto, M. M., additional, Dantas, M., additional, Olauson, H., additional, Amin, R., additional, Ponnusamy, A., additional, Goetz, R., additional, Mohammadi, M., additional, Canfield, A., additional, Kublickiene, K., additional, Rodriguez, J., additional, Reyes, E. P., additional, Cortes, P. P., additional, Fernandez, R., additional, Yoon, H. E., additional, Koh, E. S., additional, Chung, S., additional, Shin, S. J., additional, Pazzano, D., additional, Lupica, R., additional, Torre, F., additional, Costantino, G., additional, Prieto, M., additional, Gonzalez-Buitrago, J. M., additional, Lopez-Hernandez, F., additional, Morales, A. I., additional, Vicente-Vicente, L., additional, Ferreira, L., additional, Simoes, M. J., additional, Passos, C. d., additional, Schor, N. S., additional, Shimizu, M. H. M., additional, Canale, D., additional, de Braganca, A. C., additional, Andrade, L., additional, Luchi, W. M., additional, Seguro, A. C., additional, Goncalves, J., additional, Volpini, R. A., additional, Garrido, P., additional, Fernandes, J., additional, Ribeiro, S., additional, Vala, H., additional, Parada, B., additional, Alves, R., additional, Belo, L., additional, Costa, E., additional, Santos-Silva, A., additional, and Reis, F., additional

Published
2013
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21. AKI and stem cells

Author

Simone, S., primary, Cariello, M., additional, Cosola, C., additional, Sallustio, F., additional, Loverre, A., additional, Schena, F. P., additional, Grandaliano, G., additional, Gesualdo, L., additional, Pertosa, G., additional, Castellano, G., additional, Curci, C., additional, Stasi, A., additional, Simone, S., additional, Montinaro, V., additional, Ditonno, P., additional, Battaglia, M., additional, Staffieri, F., additional, Crovace, A., additional, Oortwjin, B., additional, Van Amersfoort, E., additional, Weissgarten, J., additional, Efrati, S., additional, Berman, S., additional, Abu Hamad, R., additional, Christo, J. S., additional, Aparecida Reis, L., additional, Borges, F., additional, Simoes, M. d. J., additional, Schor, N., additional, Cantaluppi, V., additional, Bruno, S., additional, Figliolini, F., additional, Medica, D., additional, Tetta, C., additional, and Camussi, G., additional

Published
2012
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22. AKI - Experimental

Author

Kaynar, K., primary, Kaynar, K., additional, Ersoz, S., additional, Aliyazioglu, R., additional, Uzun, A., additional, Ulusoy, S., additional, Al, S., additional, Ozkan, G., additional, Cansiz, M., additional, Bertocchio, J.-P., additional, Lancon, J., additional, El Moghrabi, S., additional, Galmiche, G., additional, Duong Van Huyen, J.-P., additional, Rieu, P., additional, Jaisser, F., additional, Albertoni, G., additional, Andrade, S., additional, Barreto, J. A., additional, Borges, F., additional, Schor, N., additional, Ho, W.-Y., additional, Chen, S.-H., additional, Tseng, C.-J., additional, Bienholz, A., additional, Feldkamp, T., additional, Weinberg, J. M., additional, Suller Garcia, J., additional, Naves, M., additional, Aparecida Reis, L., additional, Simoes, M. d. J., additional, S Almeida, W., additional, Moreau Longo, V., additional, Segreto, H. R. C., additional, Ghoneim, A., additional, Elkholy, A., additional, Medhat Abbas, T., additional, El Hadeedy, M., additional, Elhusseini, F., additional, Elessawey, B., additional, Eltanaihy, E., additional, Lotfy, A., additional, Eldesoky, S., additional, Sheashaa, H., additional, Sobh, M., additional, Minning, D. M., additional, Warnock, D., additional, Mohamed, A. S., additional, Wirthlin, J. B., additional, Chintalacharuvu, S. R., additional, Boone, L., additional, Brenner, R. M., additional, Santina Christo, J., additional, Dos Santos Passos, C., additional, Rene de Alencar, D., additional, De Braganca, A. C., additional, Canale, D., additional, Goncalves, J. G., additional, Brandao, T. P. B., additional, Shimizu, M. H. M., additional, Volpini, R. A., additional, Seguro, A. C., additional, Andrade, L., additional, Lee, J.-W., additional, Kim, H. K., additional, Cho, W. Y., additional, Jo, S.-K., additional, Cho, E., additional, Hocherl, K., additional, Schmidt, C., additional, Mulay, S. R., additional, Kulkarni, O. P., additional, Rupanagudi, K. V., additional, Migliorini, A., additional, Liapis, H., additional, Anders, H.-J., additional, Pevzner, I., additional, Chupyrkina, A., additional, Plotnikov, E., additional, Zorov, D., additional, Lopez-Novoa, J.-M., additional, Eleno, N., additional, Perez-Barriocanal, F., additional, Arevalo, M., additional, Docherty, N., additional, Castellano, G., additional, Divella, C., additional, Loverre, A., additional, Stasi, A., additional, Curci, C., additional, Rossini, M., additional, Ditonno, P., additional, Battaglia, M., additional, Daha, M. R., additional, Van Kooten, C., additional, Gesualdo, L., additional, Schena, F. P., additional, Grandaliano, G., additional, Tsuda, H., additional, Kawada, N., additional, Iwatani, H., additional, Moriyama, T., additional, Takahara, S., additional, Rakugi, H., additional, Isaka, Y., additional, Schley, G., additional, Kalucka, J., additional, Klanke, B., additional, Jantsch, J., additional, Olbrich, S., additional, Baumgartl, J., additional, Amann, K., additional, Eckardt, K.-U., additional, Weidemann, A., additional, Dolgolikova, A., additional, Pilotovich, V., additional, Ivanchik, G., additional, Shved, I., additional, Banki, N. F., additional, Antal, Z., additional, Hosszu, A., additional, Koszegi, S., additional, Vannay, A., additional, Wagner, L., additional, Prokai, A., additional, Muller, V., additional, Szabo, A. J., additional, Fekete, A., additional, Farrag, S., additional, Abulasrar, S., additional, Salama, , M., additional, Amin, M., additional, Ali, A., additional, Rubera, I., additional, Duranton, C., additional, Cougnon, M., additional, Melis, N., additional, Tauc, M., additional, Jankauskas, S., additional, Morosanova, M., additional, Pulkina, N., additional, Zorova, L., additional, Shin, Y. T., additional, Kim, S. S., additional, Chang, Y. K., additional, Choi, D. E., additional, Na, K.-R., additional, Lee, K. W., additional, Choi, J.-Y., additional, Jin, D.-C., additional, Cha, J.-H., additional, Schneider, R., additional, Betz, B., additional, Meusel, M., additional, Held, C., additional, Wanner, C., additional, Gekle, M., additional, Sauvant, C., additional, Pisani, A., additional, Rossano, R., additional, Mancini, A., additional, Arfian, N., additional, Yagi, K., additional, Nakayama, K., additional, Ali, H., additional, Mayasari, D. S., additional, Purnomo, E., additional, Emoto, N., additional, Efrati, S., additional, Berman, S., additional, Abu Hamad, R., additional, Weissgarten, J., additional, Scherbaum, C. R., additional, Allam, R., additional, Lichtnekert, J., additional, Darisipudi, M. N., additional, Hagele, H., additional, Hohenstein, B., additional, Hugo, C., additional, Schaefer, L., additional, Corsi, C., additional, Ferramosca, E., additional, Grandi, E., additional, Pisoni, L., additional, Rivolta, I., additional, Dalpozzo, B., additional, Hoxha, E., additional, Severi, S., additional, Santoro, A., additional, Laurent, M., additional, Cedric, R., additional, Dominique, C., additional, Sophie, V., additional, Nochy, D., additional, Loic, G., additional, Patrice, C., additional, Chantal, J., additional, Marie-Christine, V., additional, Alexandre, H., additional, Eric, R., additional, Cantaluppi, V., additional, Medica, D., additional, Quercia, A. D., additional, Figliolini, F., additional, Dellepiane, S., additional, Randone, O., additional, Segoloni, G. P., additional, Camussi, G., additional, Ahn, B.-H., additional, Kim, S. H., additional, Yasue Saito Miyagi, M., additional, Camara, N., additional, Cerqueira Leite Seelaender, M., additional, Maceratesi Enjiu, L., additional, Estler Rocha Guilherme, P., additional, Pisciottano, M., additional, Hiyane, M., additional, Yuri Hayashida, C., additional, De Andrade Oliveira, V., additional, Olsen Saraiva Camara, N., additional, Tami Amano, M., additional, Sancho-Martinez, S. M., additional, Sanchez-Juanes, F., additional, Vicente, L., additional, Gonzalez-Buitrago, J. M., additional, Morales, A. I., additional, Lopez-Novoa, J. M., additional, Lopez-Hernandez, F. J., additional, Chen, J.-S., additional, Chang, L.-C., additional, Chen, C.-C., additional, Park, M. Y., additional, Choi, S. J., additional, Kim, J. G., additional, Hwang, S. D., additional, Vicente-Vicente, L., additional, Ferreira, L., additional, Prieto, M., additional, Garcia-Sanchez, O., additional, Sevilla, M. A., additional, Lopez-Novoa, F. J., additional, Christoph, K., additional, Kuper, C., additional, Maria-Luisa, F., additional, Franz-Xaver, B., additional, Neuhofer, W., additional, Vervaet, B., additional, Le Clef, N., additional, Verhulst, A., additional, D'haese, P., additional, Tanaka, T., additional, Yamaguchi, J., additional, Eto, N., additional, Kojima, I., additional, Fujita, T., additional, Nangaku, M., additional, Wystrychowski, A., additional, Wystrychowski, G., additional, Obuchowicz, E., additional, Grzeszczak, W., additional, Wiecek, A., additional, Esposito, C., additional, Torreggiani, M., additional, Castoldi, F., additional, Migotto, C., additional, Serpieri, N., additional, Grosjean, F., additional, Manini, A., additional, Pertile, E., additional, and Dal Canton, A., additional

Published
2012
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25. Experimental models

Author

Bussolati, B., primary, Moggio, A., additional, Collino, F., additional, Grange, C., additional, Camussi, G., additional, Cantaluppi, V., additional, Gatti, S., additional, Medica, D., additional, Figliolini, F., additional, Bruno, S., additional, Deregibus, M. C., additional, Sordi, A., additional, Biancone, L., additional, Tetta, C., additional, Segoloni, G. P., additional, Castellano, G., additional, Curci, C., additional, Stasi, A., additional, Cariello, M., additional, Loverre, A., additional, Simone, S., additional, Tataranni, T., additional, Ditonno, P., additional, Lucarelli, G., additional, Battaglia, M., additional, Crovace, A., additional, Staffieri, F., additional, Gesualdo, L., additional, Schena, F. P., additional, Grandaliano, G., additional, Kim, S., additional, Heo, N. J., additional, Lee, J. W., additional, Oh, Y. K., additional, Na, K. Y., additional, Joo, K. W., additional, Earm, J.-H., additional, Han, J. S., additional, Loureiro, J., additional, Aguilera, A., additional, Selgas, R., additional, Sandoval, P., additional, Albar-Vizcaino, P., additional, Perez-Lozano, M. L., additional, Ruiz-Carpio, V., additional, Borras-Cuesta, F., additional, Dotor, J., additional, Lopez-Cabrera, M., additional, Henley, C., additional, Davis, J., additional, Lee, P., additional, Wong, S., additional, Salyers, K., additional, Wagner, M., additional, Jung, J., additional, Nguyen, H., additional, van der Valk, M., additional, Jackson, J., additional, Serafino, R., additional, Jin, L., additional, Willcockson, M., additional, Ward, S., additional, Turk, J., additional, Lu, J. Y.- L., additional, Fu, A., additional, Richards, W., additional, Reagan, J. D., additional, Medina, J., additional, Li, A.-R., additional, and Liu, J., additional

Published
2011
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32. Analysis of the Physico-Chemical, Mechanical and Biological Properties of Crosslinked Type-I Collagen from Horse Tendon: Towards the Development of Ideal Scaffolding Material for Urethral Regeneration

Author

Nunzia Gallo, Maria Lucia Natali, Claudia Curci, Angela Picerno, Anna Gallone, Marco Vulpi, Antonio Vitarelli, Pasquale Ditonno, Mariafrancesca Cascione, Fabio Sallustio, Rosaria Rinaldi, Alessandro Sannino, Luca Salvatore, Gallo, N., Natali, M. L., Curci, C., Picerno, A., Gallone, A., Vulpi, M., Vitarelli, A., Ditonno, P., Cascione, M., Sallustio, F., Rinaldi, R., Sannino, A., and Salvatore, L.

Subjects
Scaffold, Stem cell, Tissue engineering, Type I collagen, Urethra, Technology, Microscopy, QC120-168.85, type I collagen, urethra, stem cell, scaffold, tissue engineering, QH201-278.5, Engineering (General). Civil engineering (General), Article, TK1-9971, Descriptive and experimental mechanics, General Materials Science, Electrical engineering. Electronics. Nuclear engineering, TA1-2040
Abstract

Urethral stenosis is a pathological condition that consists in the narrowing of the urethral lumen because of the formation of scar tissue. Unfortunately, none of the current surgical approaches represent an optimal solution because of the high stricture recurrence rate. In this context, we preliminarily explored the potential of an insoluble type-I collagen from horse tendon as scaffolding material for the development of innovative devices for the regeneration of injured urethral tracts. Non-porous collagen-based substrates were produced and optimized, in terms of crosslinking density of the macromolecular structure, to either provide mechanical properties compliant with the urinary tract physiological stress and better sustain tissue regeneration. The effect of the adopted crosslinking strategy on the protein integrity and on the substrate physical–chemical, mechanical and biological properties was investigated in comparison with a decellularized matrix from porcine small intestinal submucosa (SIS patch), an extensively used xenograft licensed for clinical use in urology. The optimized production protocols allowed the preservation of the type I collagen native structure and the realization of a substrate with appealing end-use properties. The biological response, preliminarily investigated by immunofluorescence experiments on human adult renal stem/progenitor cells until 28 days, showed the formation of a stem-cell monolayer within 14 days and the onset of spheroids within 28 days. These results suggested the great potential of the collagen-based material for the development of scaffolds for urethral plate regeneration and for in vitro cellular studies.

Published
2021

33. Neuromuscular Diseases and Bone

Author

Antimo Moretti, Sara Liguori, Claudio Curci, Marco Paoletta, Giovanni Iolascon, Iolascon, G, Paoletta, M, Liguori, S, Curci, C, and Moretti, A

Subjects
0301 basic medicine, Endocrinology, Diabetes and Metabolism, Osteoporosis, Psychological intervention, physical activity, 030209 endocrinology & metabolism, neuromuscular diseases, vitamin D, Review, Bone tissue, Bioinformatics, lcsh:Diseases of the endocrine glands. Clinical endocrinology, vitamin D deficiency, rehabilitation, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Endocrinology, medicine, osteoporosi, Adverse effect, lcsh:RC648-665, glucocorticoids, business.industry, neuromuscular disease, fractures, medicine.disease, osteoporosis, Malnutrition, 030104 developmental biology, medicine.anatomical_structure, fracture, glucocorticoid, Secondary osteoporosis, business
Abstract

Neuromuscular diseases (NMDs) are inherited or acquired conditions affecting skeletal muscles, motor nerves, or neuromuscular junctions. Most of them are characterized by a progressive damage of muscle fibers with reduced muscle strength, disability, and poor health-related quality of life of affected patients. In this scenario, skeletal health is usually compromised as a consequence of modified bone-muscle cross-talk including biomechanical and bio-humoral issues, resulting in increased risk of bone fragility and fractures. In addition, NMD patients frequently face nutritional issues, including malnutrition due to feeding disorders and swallowing problems that might affect bone health. Moreover, in these patients, low levels of physical activity or immobility are common and might lead to overweight or obesity that can also interfere with bone strength features. Also, vitamin D deficiency could play a critical role both in the pathogenesis and in the clinical scenario of many NMDs, suggesting that its correction could be useful in maintaining or enhancing bone health, especially in the early phases of NMDs. Last but not least, specific disease-modifying drugs, available for some NMDs, are frequently burdened with adverse effects on bone tissue. For example, glucocorticoid therapy, standard of care for many muscular dystrophies, prolongs long-term survival in treated patients; nevertheless, high dose and/or chronic use of these drugs are a common cause of secondary osteoporosis. This review addresses the current state of knowledge about the factors that play a role in determining bone alterations reported in NMDs, how these factors can modify the biological pathways underlying bone health, and which are the available interventions to manage bone involvement in patients affected by NMDs. Considering the complexity of care of these patients, an interdisciplinary and multimodal management strategy based on both pharmacological and non-pharmacological interventions is recommended, particularly targeting musculoskeletal issues that are closely related to functional independence as well as social implications.

Published
2019
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36. Rehabilitation therapy after surgery in osteoporotic patients

Author

Claudio Curci, Alessandro de Sire, Francesca Gimigliano, Giovanni Iolascon, Antimo Moretti, Lenzi A., Migliaccio S., Gimigliano, F., de Sire, A., Moretti, A., Curci, C., and Iolascon, G.

Subjects
musculoskeletal diseases, medicine.medical_specialty, Surgical approach, Rehabilitation, business.industry, medicine.medical_treatment, Osteoporosis, Wrist, medicine.disease, Increased risk, medicine.anatomical_structure, Skeletal disorder, Quality of life, medicine, Physical therapy, Ankle, business
Abstract

Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fragility fractures that could induce long-term morbidity, functional limitation, decreased quality of life, and increase mortality. The most frequent sites of fragility fractures are the vertebrae, hip, wrist, proximal humerus, and ankle. In several cases, a surgical approach with subsequent rehabilitative treatment is required. The main aims of rehabilitation are restoring pre-fracture functioning and improving patients’ activities, participation level, and quality of life.

Published
2018

38. P385 EFFECTIVENESS OF DENOSUMAB IN REDUCING BACK PAIN AND IN IMPROVING BONE MINERAL DENSITY AND HEALTH RELATED QUALITY OF LIFE: 1-YEAR FOLLOW-UP PROSPECTIVE STUDY I N POSTMENOPAUSAL WOMEN WITH VERTEBRAL FRAGILITY FRACTURES

Author

A. de Sire, MORETTI A, G. Di Pietro, C. Curci, A. Mazzola, F. Gimigliano, G. Iolascon, de Sire, A., Moretti, A, Di Pietro, G., Curci, C., Mazzola, A., Gimigliano, F., and Iolascon, G.

Abstract

Objective: To assess the effectiveness of denosumab in reducing back pain related disability and in improving bone mineral density (BMD) and Health Related Quality of Life (HRQoL) in osteoporotic postmenopausal women with vertebral fractures. Material and Methods:We enrolled women aged ≥50 years with a diagnosis of postmenopausal osteoporosis that had experienced at least one vertebral fragility fracture. We administered subcutaneous denosumab (60 mg/every 6 months) and a supplementation of calcium carbonate (500- 1000 mg/day) and cholecalciferol (800 IU/day) for 1 year. We assessed at the baseline (T0), after 6 months (T1), and after 12 months (T2) of treatment the following outcomes: back pain related disability, assessed by Spine Pain Index (SPI), and HRQoL, using the 12-Item Short Form Health Survey (SF-12), with Physical (PCS) and Mental Health Composite Scores (MCS) and the European Quality of Life - 5 Dimensions - 3 Levels (EuroQol-5D-3L) index (EQ-5D-3L index) and the EuroQol-Visual Analogue Scale scores (EQ VAS). Moreover, we evaluated lumbar spine (LS) and femoral neck (FN) BMD at T0 and T2. Results: We assessed 140 women, mean aged 74.9±8.8 years, with a mean BMI of 26.1±3.9 kg/m2. Results are reported in Table 1. Conclusions: Our data analysis demonstrated that 1-year treatment with denosumab was significantly effective in reducing back pain related disability and in improving BMD and HRQoL in a cohort of postmenopausal women with at least one vertebral fracture.

Published
2017

39. Early Denosumab for the prevention of osteoporotic fractures in breast cancer women undergoing aromatase inhibitors: A case-control retrospective study

Author

Giovanni Iolascon, Vincenzo Falco, Alessandro de Sire, Dalila Scaturro, Fabio Vitagliani, Daniele Cuntrera, Pietro Terrana, Giulia Letizia Mauro, Claudio Curci, Scaturro, Dalila, de Sire, Alessandro, Terrana, Pietro, Curci, Claudio, Vitagliani, Fabio, Falco, Vincenzo, Cuntrera, Daniele, Iolascon, Giovanni, Mauro, Giulia Letizia, Scaturro Dalila, de Sire Alessandro, Terrana Pietro, Curci Claudio, Vitagliani Fabio, Falco Vincenzo, Cuntrera Daniele, Iolascon Giovanni, Letizia Mauro Giulia, Scaturro, D., De Sire, A., Terrana, P., Curci, C., Vitagliani, F., Falco, V., Cuntrera, D., Iolascon, G., and Mauro, G. L.

Subjects
Osteoporosis, risk of fracture, 0302 clinical medicine, Retrospective Studie, Bone Density, Orthopedics and Sports Medicine, 030212 general & internal medicine, Aromatase, Osteoporosis, Postmenopausal, biology, Bone Density Conservation Agents, Aromatase Inhibitors, Settore MED/34 - Medicina Fisica E Riabilitativa, Medical record, Rehabilitation, Middle Aged, medicine.anatomical_structure, Denosumab, 030220 oncology & carcinogenesis, Osteoporosis, risk of fractures, breast cancer, denosumab, bone health, Female, Case-Control Studie, Breast Neoplasm, Human, medicine.drug, medicine.medical_specialty, Bone Density Conservation Agent, Physical Therapy, Sports Therapy and Rehabilitation, Breast Neoplasms, Bone health, 03 medical and health sciences, breast cancer, Breast cancer, Internal medicine, medicine, Aromatase Inhibitor, Humans, bone health, Femoral neck, Aged, Retrospective Studies, risk of fractures, business.industry, Osteoporosi, Retrospective cohort study, medicine.disease, Case-Control Studies, biology.protein, business, Osteoporotic Fractures
Abstract

BACKGROUND: Aromatase inhibitors (AIs) might have a detrimental impact on bone health in breast cancer (BC) women. Denosumab has been shown to reduce the risk of fractures, but the appropriate time for starting is yet to be clearly defined. OBJECTIVE: To evaluate the effects of early treatment with Denosumab (⩽ 12 months after starting AIs) compared to a delayed treatment in BC women. METHODS: In this retrospective case-control study, we included medical records of BC post-menopausal women, treated with AIs therapy; they were divided as: study group (starting Denosumab ⩽ 12 months after AIs) and control group (> 12 months). At the baseline (T0) and at 18 months (T1), we evaluated the lumbar spine (LS) Tscore and femoral neck (FN) Tscore. Furthermore, at T1 we assessed the incident fragility fractures. RESULTS: Fifty-nine BC survivors (mean age: 61.5 ± 11.5 years) were included: 28 with Early Denosumab and 31 with Late Denosumab. At T1, the study group did not show any incident hip or vertebral fragility fracture, whereas the Late Denosumab group showed 2 incident hip fractures (6.5%) and 4 (12.9%) vertebral fragility fractures. Early Denosumab showed a significant positive effect on both LS (p= 0.044) and FN (p= 0.024) Tscore variations. CONCLUSION: Taken together, our findings suggest that an early start of Denosumab might be considered for the osteoporosis management in BC women undergoing AIs.

40. Efficacy of Rehabilitative Techniques on Pain Relief in Patients With Vulvodynia: A Systematic Review and Meta-Analysis.

Author

Calafiore D, Marotta N, Curci C, Agostini F, De Socio RI, Inzitari MT, Ferraro F, Bernetti A, Ammendolia A, and de Sire A

Subjects
Humans, Female, Randomized Controlled Trials as Topic, Physical Therapy Modalities, Pain Measurement, Pelvic Floor physiopathology, Vulvodynia rehabilitation, Pain Management methods
Abstract

Objective: Vulvodynia is a chronic clinical condition characterized by provoked or non-provoked vulvar pain for at least 3 months of unknown etiology. The onset of vulvodynia involves a complex interplay of peripheral and central pain mechanisms, such as pelvic floor muscle and autonomic dysfunction, and interpersonal factors. A stepwise approach of pelvic floor physical therapy as medical management is suggested. In this scenario, by this meta-analysis of randomized controlled trials, we aimed to evaluate the efficacy of rehabilitation interventions in patients with vulvodynia., Methods: On October 13, 2022, PubMed, Scopus, and Web of Science were systematically searched for randomized controlled trials that assessed the efficacy of the rehabilitative approach to pain during intercourse in patients with vulvodynia. The quality assessment was performed with the Cochrane risk-of-bias tool for randomized trials. The trial registration number is CRD42021257449. At the end of the search, 9 studies were included for a total of 332 patients. A pairwise meta-analysis was performed to highlight the efficacy of rehabilitative approaches for reducing pain during intercourse, as measured with a visual analog scale or a numerical rating scale., Results: Meta-analysis showed that all these rehabilitative approaches had an overall effect size of -1.43 (95% CI = -2.69 to -0.17) in decreasing vulvodynia pain in terms of the visual analog scale. In the subgroup analysis, a significant effect size in acupuncture (effect size = -2.36; 95% CI = -3.83 to -0.89) and extracorporeal shockwave therapy (effect size = -2.94; 95% CI = -4.31 to -1.57; I2 = 58%) was observed. According to the Cochrane risk-of-bias tool, a low risk of bias for outcome selection in 89% of studies., Conclusion: Findings from this meta-analysis suggested that the physical agent modalities and complementary medicine techniques in people with vulvodynia appear to be more effective than placebo, sham, or waiting list. Further evidence on physical agent modalities and complementary therapies are warranted in the future., Impact: This was the first systematic review and meta-analysis of randomized controlled trials to provide evidence on the efficacy of rehabilitation interventions in patients with vulvodynia., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Physical Therapy Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2024
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41. Comprehensive Pulmonary Rehabilitation for Patients with Malignant Pleural Mesothelioma: A Feasibility Pilot Study.

Author

Lippi L, de Sire A, Folli A, Curci C, Calafiore D, Lombardi M, Bertolaccini L, Turco A, Ammendolia A, Fusco N, Spaggiari L, and Invernizzi M

Abstract

Malignant pleural mesothelioma (MPM) represents a significant health burden, with limited treatment options and poor prognosis. Despite advances in pharmacological and surgical interventions, the role of rehabilitation in MPM management remains underexplored. This study aims to assess the feasibility of a tailored pulmonary rehabilitation intervention addressing physical and respiratory function in MPM patients. A prospective pilot study was conducted on surgically treated MPM patients referred to a cardiopulmonary rehabilitation service. The intervention comprised multidisciplinary educational sessions, physical rehabilitation, and respiratory physiotherapy. Feasibility was evaluated based on dropout rates, adherence to the rehabilitation program, safety, and patient-reported outcomes. Twelve patients were initially enrolled, with seven completing the study. High adherence to physical (T1: 93.43%, T2: 82.56%) and respiratory (T1: 96.2%, T2: 92.5%) rehabilitation was observed, with minimal adverse events reported. Patient satisfaction remained high throughout the study (GPE scores at T1: 1.83 ± 1.17; T2: 2.0 ± 1.15), with improvements noted in physical function, pain management, and health-related quality of life. However, some issues, such as time constraints and lack of continuous supervision, were reported by participants. This pilot study demonstrates the feasibility and potential benefits of a tailored pulmonary rehabilitation intervention in MPM patients. Despite its promising outcomes, further research with larger samples is warranted to validate its efficacy and integrate rehabilitation as a component into the multidisciplinary management of MPM.

Published
2024
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42. Skeletal maturation evaluation: which is the reliability of dental calcification Demirjian method versus hand-wrist X-ray in growing subjects? A systematic review.

Author

Ferrillo M, Migliario M, Curci C, Renò F, Giudice A, and De Sire A

Subjects
Humans, Reproducibility of Results, Tooth Calcification physiology, Age Determination by Skeleton methods, Hand, Age Determination by Teeth methods, Cross-Sectional Studies, Female, Male, Child, Wrist
Abstract

Objectives: This systematic review aimed at evaluating the reliability of dental maturation (DM) according to Demirjian method compared to hand and wrist maturation (HWM) to assess skeletal maturity (SM) in growing subjects, to identify the teeth and the corresponding mineralisation stages related to the pubertal growth spurt (PGS)., Materials and Methods: PubMed, Scopus, and Web of Science were systematically searched until January 5th, 2024, to identify observational cross-sectional studies that assessed the reliability of Demirjian method compared to the HWM methods (i.e., Grave and Brown and Fishman) in growing subjects. The quality assessment was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist., Results: Out of 136 papers suitable for title/abstract screening, 19 included studies. Of them, 17 papers showed the reliability of Demirjian DM method compared to HWM Fishman and Grave and Brown methods to assess SM in growing subjects. According to JBI Critical Appraisal Checklist, 12 papers were high-quality studies and 7 papers were medium-quality studies.  Conclusions: The mandibular second molar might be considered as the best indicator compared to other teeth and that the peak of growth occurs no earlier than stage F in females and stage G in males according to Demirjian method. Also, the mandibular canine might be analysed as indicator of SM in males, and results suggest that the peak of growth occurs no earlier than maturation stage F according to Demirjian method, only in male subjects. Further studies are needed to confirm these findings.

Published
2024
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43. Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery.

Author

Lippi L, Ferrillo M, Losco L, Folli A, Marcasciano M, Curci C, Moalli S, Ammendolia A, de Sire A, and Invernizzi M

Subjects
Humans, Quality of Life, Physical Therapy Modalities, Cosmetic Techniques standards, Recovery of Function, Esthetics
Abstract

Although rehabilitation medicine emphasizes a holistic health approach, there is still a large gap of knowledge about potential interventions aimed at improving overall wellbeing through cosmetic interventions. Therefore, this narrative review investigates the role of different rehabilitative techniques in enhancing aesthetics, quality of life, and psychosocial wellbeing for patients with disabilities. The study follows the SANRA framework quality criteria for a narrative review. Literature searches across PubMed/Medline, Web of Science, and Scopus identified articles focusing on rehabilitation strategies within the aesthetic rehabilitation domain. The review identified evidence supporting injection procedures, such as Botulinum Toxin, Platelet-Rich Plasma, Hyaluronic Acid, Ozone, and Carboxytherapy, and assessing their applications in several disabling disorders. Additionally, physical therapies like Extracorporeal Shock Wave Therapy, Laser Therapy, Microcurrent Therapy, Tecar Therapy, and physical exercises were explored for their impact on cutaneous microcirculation, cellulite treatment, wound healing, and scar appearance improvement. Lastly, the manuscript underlines the role of manual therapy techniques in addressing both physical discomfort and aesthetic concerns, discussing their effectiveness in adipose tissue therapy, scar tissue mobilization, and regional fat thickness reduction. Taken together, this review emphasizes the role of a multidisciplinary approach, aiming to provide valuable insights into potential benefits for both functional and aesthetic outcomes.

Published
2024
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44. Ultrasound-Assisted, Catheter-Directed Thrombolysis for Acute Intermediate/High-Risk Pulmonary Embolism: Design of the Multicenter USAT IH-PE Registry and Preliminary Results.

Author

Colombo C, Capsoni N, Russo F, Iannaccone M, Adamo M, Viola G, Bossi IE, Villanova L, Tognola C, Curci C, Morelli F, Guerrieri R, Occhi L, Chizzola G, Rampoldi A, Musca F, De Nittis G, Galli M, Boccuzzi G, Savio D, Bernasconi D, D'Angelo L, Garascia A, Chieffo A, Montorfano M, Oliva F, and Sacco A

Abstract

Catheter-based revascularization procedures were developed as an alternative to systemic thrombolysis for patients with intermediate-high- and high-risk pulmonary embolisms. USAT IH-PE is a retrospective and prospective multicenter registry of such patients treated with ultrasound-facilitated, catheter-directed thrombolysis, whose preliminary results are presented in this study. The primary endpoint was the incidence of pulmonary hypertension (PH) at follow-up. Secondary endpoints were short- and mid-term changes in the echocardiographic parameters of right ventricle (RV) function, in-hospital and all-cause mortality, and procedure-related bleeding events. Between March 2018 and July 2023, 102 patients were included. The majority were at intermediate-high-risk PE (86%), were mostly female (57%), and had a mean age of 63.7 ± 14.5 years, and 28.4% had active cancer. Echocardiographic follow-up was available for 70 patients, and in only one, the diagnosis of PH was confirmed by right heart catheterization, resulting in an incidence of 1.43% (CI 95%, 0.036-7.7). RV echocardiographic parameters improved both at 24 h and at follow-up. In-hospital mortality was 3.9% (CI 95%, 1.08-9.74), while all-cause mortality was 11% (CI 95%, 5.4-19.2). Only 12% had bleeding complications, of whom 4.9% were BARC ≥ 3. Preliminary results from the USAT IH-PE registry showed a low incidence of PH, improvement in RV function, and a safe profile.

Published
2024
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45. Effects of intensive rehabilitation on functioning in patients with mild and moderate Charcot-Marie-Tooth disease: a real-practice retrospective study.

Author

Ferraro F, Calafiore D, Curci C, Fortunato F, Carantini I, Genovese F, Lucchini G, Merlo A, Ammendolia A, and de Sire A

Subjects
Humans, Adult, Middle Aged, Retrospective Studies, Walking physiology, Exercise Therapy methods, Physical Therapy Modalities, Charcot-Marie-Tooth Disease
Abstract

Charcot-Marie-Tooth (CMT) disease is one of the most common inherited neuropathies and can lead to progressive muscular weakness, pes cavus, loss of deep tendon reflexes, distal sensory loss, and gait impairment. There are still no effective drugs or surgical therapies for CMT, and supportive treatment is limited to rehabilitative therapy and surgical treatment of skeletal deformities. Many rehabilitative therapeutic approaches have been proposed, but timing and cadence of rehabilitative intervention are not clearly defined, and long-term follow-up is lacking in literature. The aim of this real-practice retrospective study was to assess the effectiveness of an intensive neurorehabilitation protocol on muscle strength and functioning in CMT patients. We analyzed data of patients with diagnosis of mild to moderate CMT. The rehabilitation program lasted 2-4 h a day, 5 days a week, for 3 weeks and consisted of manual treatments, strengthening exercises, stretching, core stability, balance and resistance training, aerobic exercises, and tailored self-care training. Data were collected at baseline (T 0 ), after treatment (T 1 ), and at the 12-month mark (T 2 ) in terms of the following outcome measures: muscle strength, pain, fatigue, cramps, balance, walking speed, and ability. We included 37 CMT patients with a median age of 50.72 ± 13.31 years, with different forms: demyelinating (n = 28), axonal (n = 8), and mixed (n = 1). After intensive rehabilitation treatment, all outcomes significantly improved. This improvement was lost at the 1-year mark. Taken together, these findings suggest that an intensive rehabilitation program improves short-term symptoms and functional outcomes in a cohort of inpatients affected by mild to moderate CMT., (© 2023. The Author(s).)

Published
2024
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46. Elevated levels of IL-6 in IgA nephropathy patients are induced by an epigenetically driven mechanism modulated by viral and bacterial RNA.

Author

Sallustio F, Picerno A, Cimmarusti MT, Montenegro F, Curci C, De Palma G, Sivo C, Annese F, Fontò G, Stasi A, Pesce F, Tafuri S, Di Leo V, and Gesualdo L

Subjects
Humans, Immunoglobulin A, Interleukin-6, Leukocytes, Mononuclear metabolism, Leukocytes, Mononuclear pathology, RNA, Bacterial, Glomerulonephritis, IGA genetics
Abstract

Background: Immunoglobulin A nephropathy (IgAN) is the most frequent primary glomerulonephritis and the role of IL-6 in pathogenesis is becoming increasingly important. A recent whole genome DNA methylation screening in IgAN patients identified a hypermethylated region comprising the non-coding RNA Vault RNA 2-1 (VTRNA2-1) that could explain the high IL-6 levels., Methods: The pathway leading to IL-6 secretion controlled by VTRNA2-1, PKR, and CREB was analyzed in peripheral blood mononuclear cells (PBMCs) isolated from healthy subjects (HS), IgAN patients, transplanted patients with or without IgAN. The role of double and single-strand RNA in controlling the pathway was investigated., Results: VTRNA2-1 was downregulated in IgAN compared to HS and in transplanted IgAN patients (TP-IgAN) compared to non-IgAN transplanted (TP). The loss of the VTRNA2-1 natural restrain in IgAN patients caused PKR hyperphosphorylation, and consequently the activation of CREB by PKR, which, in turn, led to high IL-6 production, both in IgAN and in TP-IgAN patients. IL-6 levels could be decreased by the PKR inhibitor imoxin. In addition, PKR is normally activated by bacterial and viral RNA, and we found that both the RNA poly(I:C), and the COVID-19 RNA-vaccine stimulation significantly increased the IL-6 levels in PBMCs from HS but had an opposite effect in those from IgAN patients., Conclusion: The discovery of the upregulated VTRNA2-1/PKR/CREB/IL-6 pathway in IgAN patients may provide a novel approach to treating the disease and may be useful for the development of precision nephrology and personalized therapy by checking the VTRNA2-1 methylation level in IgAN patients., Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest., (Copyright © 2023. Published by Elsevier B.V.)

Published
2023
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47. Role of Prehabilitation and Rehabilitation on Functional Recovery and Quality of Life in Thyroid Cancer Patients: A Comprehensive Review.

Author

Lippi L, Turco A, Moalli S, Gallo M, Curci C, Maconi A, de Sire A, and Invernizzi M

Abstract

Background: This narrative review aims to provide a comprehensive overview of the current prehabilitation and rehabilitation strategies for thyroid cancer survivors to optimize functional outcomes and enhance their quality of life., Methods: The review follows the SANRA quality criteria and includes an extensive literature search conducted in PubMed/Medline, Web of Science, and Scopus., Results: The review emphasizes the role of a comprehensive rehabilitation approach in targeting the different domains that generate disability in thyroid cancer patients. In this context, physical activity, range of motion exercises, myofascial release, joint mobilization, and postural exercises are crucial for improving functional outcomes and reducing treatment-related discomfort and disability. Moreover, tailored rehabilitative management addressing dysphonia and dysphagia might have a positive impact on the quality of life of these patients. Despite these considerations, several barriers still affect the implementation of a multimodal rehabilitative approach in common clinical practice. Thus, sustainable and effective strategies like digital innovation and patient-centered approaches are strongly needed in order to implement the rehabilitative treatment framework of these subjects., Conclusions: This narrative review provides valuable insights into the current prehabilitation and rehabilitation strategies to treat thyroid cancer survivors, addressing physical, psychological, and vocational needs to optimize functional outcomes and enhance their quality of life.

Published
2023
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48. Impact of COVID-19 Era on the Anterior Cruciate Ligament Injury Rehabilitation: A Scoping Review.

Author

Marotta N, de Sire A, Calafiore D, Agostini F, Lippi L, Curci C, Ferraro F, Bernetti A, Invernizzi M, and Ammendolia A

Abstract

The surgical intervention rate and the subsequent rehabilitation plan for anterior cruciate ligament (ACL) injury was crucially affected by the COVID-19 pandemic due to the necessity in the face of the emergency. This review aimed to evaluate potential persistent and residual symptoms after COVID-19 disease, including fatigue and neuromuscular disorders. A scoping review design and methodology were used due to the exploratory nature of the research question, according to literature searches on PubMed/Medline, Scopus, Web of Science (WoS), and Physiotherapy Evidence Database (PEDro) electronic databases using the following keywords: "Anterior Cruciate Ligament", "ACL", "SARS-CoV-2", and "COVID-19". Undertraining and muscular knee imbalance might cause inefficient movement strategies, lack of knee stability, and increasing load with negative implications in ACL injuries. In the post-surgery period, during COVID-19, telerehabilitation approaches appeared to be successfully applied to maintain strength and range of motion in this condition. However, no definitive data are available regarding the most effective interventions. This scoping review showed the influence of the COVID-19 pandemic and associated restrictions on postoperative and rehabilitative care of ACL injuries.

Published
2023
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49. A wearable inertial system to evaluate Tai Chi training motor effects in patients with Parkinson's disease .

Author

Mancioppi G, Cavallo F, Benvenuti P, Francalanci B, Fiorini L, Alfieri M, Curci C, Benetti R, Cagliari M, Cesene M, Ferraro F, and Rovini E

Subjects
Humans, Exercise Therapy, Movement, Parkinson Disease therapy, Tai Ji methods, Wearable Electronic Devices
Abstract

Physical therapy is strongly recommended for patients with neurological disorders. Tai Chi-based treatments seem to improve physical functions like gait speed and balance. However, assessments after treatment rely on semi-quantitative clinical scales affected by subjectivity with controversial results. This study aims at investigating whether Tai Chi could be a valid alternative to traditional physiotherapy rehabilitation. We propose a wearable system composed of two inertial devices able to objectively measure the effect of the rehabilitation treatment on the range of movement of the trunk. Seventeen patients with Parkinson's Disease (PD) were recruited and assessed. They have been randomly divided into two groups: group 1 followed a Tai Chi-based treatment, while group 2 underwent a traditional physiotherapy rehabilitation. The two groups have been assessed before (t0) and after the treatment (t1). No statistical differences have been found in the relative range of motion between the upper and lower sensors between the two groups at the baseline. Both treatments resulted in a significant improvement in the trunk range of movement (on the right side). Notably, the improvement in the effect size of the treatment was greater in group 1 than in group 2. In fact, even if both the groups benefited from their treatment group 1 gained larger mobility of the trunk if compared to group 2. Interestingly, no differences have been accounted adopting the traditional UPDRS III for motor symptoms of PD, strengthening the idea that objective measurement coming from wearable biomedical sensors could detect information otherwise neglected by traditional clinical tools.Clinical Relevance- This study preliminary confirms that beneficial motor effects after a Tai Chi rehabilitation program are comparable and quite better than after traditional physiotherapy, promoting Tai Chi as a valid alternative treatment for PD patients.

Published
2023
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50. Human Adult Renal Progenitor Cells Prevent Cisplatin-Nephrotoxicity by Inducing CYP1B1 Overexpression and miR-27b-3p Down-Regulation through Extracellular Vesicles.

Author

Franzin R, Stasi A, De Palma G, Picerno A, Curci C, Sebastiano S, Campioni M, Cicirelli A, Rizzo A, Di Lorenzo VF, Pontrelli P, Pertosa GB, Castellano G, Gesualdo L, and Sallustio F

Subjects
Adult, Humans, Cytochrome P-450 CYP1B1 genetics, Cytochrome P-450 CYP1B1 metabolism, Down-Regulation genetics, Extracellular Vesicles genetics, Extracellular Vesicles metabolism, Cisplatin adverse effects, Cisplatin metabolism, Cisplatin pharmacology, Kidney drug effects, Kidney metabolism, MicroRNAs genetics, MicroRNAs metabolism, Stem Cells metabolism
Abstract

Cisplatin is one of the most effective chemotherapeutic agents strongly associated with nephrotoxicity. Tubular adult renal progenitor cells (tARPC) can regenerate functional tubules and participate in the repair processes after cisplatin exposition. This study investigated the molecular mechanisms underlying the protective effect of tARPC on renal epithelium during cisplatin nephrotoxicity. By performing a whole-genome transcriptomic analysis, we found that tARPC, in presence of cisplatin, can strongly influence the gene expression of renal proximal tubular cell [RPTEC] by inducing overexpression of CYP1B1, a member of the cytochrome P450 superfamily capable of metabolizing cisplatin and of hypoxia/cancer-related lncRNAs as MIR210HG and LINC00511. Particularly, tARPC exerted renoprotection and regeneration effects via extracellular vesicles (EV) enriched with CYP1B1 and miR-27b-3p, a well-known CYP1B1 regulatory miRNA. The expression of CYP1B1 by tARPC was confirmed by analyzing biopsies of cisplatin-treated renal carcinoma patients that showed the colocalization of CYP1B1 with the tARPC marker CD133. CYP1B1 was also overexpressed in urinary EV purified from oncologic patients that presented nephrotoxicity episodes after cisplatin treatment. Interestingly CYP1B1 expression significantly correlated with creatinine and eGFR levels. Taken together, our results show that tARPC are able to counteract cisplatin-induced nephrotoxicity via CYP1B1 release through EV. These findings provide a promising therapeutic strategy for nephrotoxicity risk assessment that could be related to abundance of renal progenitors.

Published
2023
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