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43 results on '"Curren, Rodger D."'

3. USA

Author

Curren, Rodger D., primary, Hill, Erin H., additional, and Stephens, Martin L., additional

Published
2019
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4. Contributors

Author

Austin, Christopher P., primary, Balls, Michael, additional, Blaauboer, Bas J., additional, Botham, Philip, additional, Burt, Tal, additional, Casey, Warren, additional, Červinka, Miroslav, additional, Cheng, Shujun, additional, Combes, Robert D., additional, Corvi, Raffaella, additional, Cronin, Mark T.D., additional, Curren, Rodger D., additional, De Angelis, Isabella, additional, Dehne, Eva-Maria, additional, Doe, John, additional, Eskes, Chantra, additional, Feigenbaum, Alexandre, additional, Forgacs, Zsolt, additional, Forsby, Anna, additional, France, Malcolm P., additional, Freeman Bain, Simon A., additional, Goldberg, Alan, additional, Gruber, Franz P., additional, Guillouzo, André, additional, Hartung, Thomas, additional, Heinonen, Tuula, additional, Hickman, James, additional, Hill, Erin H., additional, Imai, Koichi, additional, Kandarova, Helena, additional, Kavlock, Robert J., additional, Kenna, J Gerry, additional, Knudsen, Lisbeth E., additional, Kojima, Hajime, additional, Kolar, Roman, additional, Leist, Marcel, additional, Lidbury, Brett A., additional, Lowit, Anna, additional, Minor, Philip, additional, Pfaller, Walter, additional, Prieto, Pilar, additional, Ram, Rebecca, additional, Repetto, Guillermo, additional, Rogiers, Vera, additional, Roi, Annett J., additional, Rowan, Andrew, additional, Sakai, Yasuyuki, additional, Sesardic, Thea, additional, Shuler, Michael, additional, Śladowski, Dariusz, additional, Spielmann, Horst, additional, Stephens, Martin L., additional, Tähti, Hanna, additional, Tanaka, Noriho, additional, Testai, Emanuela, additional, Tice, Raymond R., additional, Trigwell, Susan, additional, Verfaillie, Catherine, additional, von Aulock, Sonja, additional, Worth, Andrew P., additional, Yoon, Miyoung, additional, and Zuang, Valérie, additional

Published
2019
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18. In Vitro Human Tissue Models in Risk Assessment: Report of a Consensus-Building Workshop

Author

MacGregor, James T., Collins, Jerry M., Sugiyama, Yuichi, Tyson, Charles A., Dean, Jack, Smith, Lewis, Andersen, Melvin, Curren, Rodger D., Houston, J. Brian, Kadlubar, Fred F., Kedderis, Gregory L., Krishnan, Kannan, Li, Albert P., Parchment, Ralph E., Thummel, Kenneth, Tomaszewski, Joseph E., Ulrich, Roger, Vickers, Alison E. M., and Wrighton, Steven A.

Published
2001

19. From inhumane to in vitro: the changing face of science

Author

Curren, Rodger D. and Hill, Erin H.

Subjects
Animal models in research -- Usage, Research -- Innovations, Toxicity testing -- In vitro, Zoology and wildlife conservation
Abstract

The development of alternative methods of testing cosmetics and drugs without the use of animals is discussed, with focus on the drawbacks of these methods and the lengthy validation procedures required.

Published
2000

20. Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays.

Author

Pfuhler, Stefan, Downs, Thomas R, Hewitt, Nicola J, Hoffmann, Sebastian, Mun, Greg C, Ouedraogo, Gladys, Roy, Shambhu, Curren, Rodger D, and Aardema, Marilyn J

Subjects
GENETIC toxicology, NUCLEOLUS, GENETIC mutation, CELL culture, ANIMAL experimentation, HUMAN beings
Abstract

In vitro test batteries have become the standard approach to determine the genotoxic potential of substances of interest across industry sectors. While useful for hazard identification, standard in vitro genotoxicity assays in 2D cell cultures have limited capability to predict in vivo outcomes and may trigger unnecessary follow-up animal studies or the loss of promising substances where animal tests are prohibited or not desired. To address this problem, a team of regulatory, academia and industry scientists was established to develop and validate 3D in vitro human skin-based genotoxicity assays for use in testing substances with primarily topical exposure. Validation of the reconstructed human skin micronucleus (RSMN) assay in MatTek Epi-200™ skin models involved testing 43 coded chemicals selected by independent experts, in four US/European laboratories. The results were analysed by an independent statistician according to predefined criteria. The RSMN assay showed a reproducibly low background micronucleus frequency and exhibited sufficient capacity to metabolise pro-mutagens. The overall RSMN accuracy when compared to in vivo genotoxicity outcomes was 80%, with a sensitivity of 75% and a specificity of 84%, and the between- and within-laboratory reproducibility was 77 and 84%, respectively. A protocol involving a 72-h exposure showed increased sensitivity in detecting true positive chemicals compared to a 48-h exposure. An analysis of a test strategy using the RSMN assay as a follow-up test for substances positive in standard in vitro clastogenicity/aneugenicity assays and a reconstructed skin Comet assay for substances with positive results in standard gene mutation assays results in a sensitivity of 89%. Based on these results, the RSMN assay is considered sufficiently validated to establish it as a 'tier 2' assay for dermally exposed compounds and was recently accepted into the OECD's test guideline development program. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Follow-up to the ECVAM Prevalidation Study on In Vitro Tests for Acute Skin Irritation

Author

Zuang, Valérie, primary, Balls, Michael, additional, Botham, Philip A., additional, Coquette, Alain, additional, Corsini, Emanuela, additional, Curren, Rodger D., additional, Elliott, Graham R., additional, Fentem, Julia H., additional, Heylings, Jon R., additional, Liebsch, Manfred, additional, Medina, Jesús, additional, Roguet, Roland, additional, van de Sandt, Johannes J.M., additional, Wiemann, Christianne, additional, and Worth, Andrew P., additional

Published
2002
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31. The Validation of Toxicological Prediction Models

Author

Archer, Graeme, primary, Balls, Michael, additional, Bruner, Leon H., additional, Curren, Rodger D., additional, Fentem, Julia H., additional, Holzhütter, Hermann-Georg, additional, Liebsch, Manfred, additional, Lovell, David P., additional, and Southee, Jacqueline A., additional

Published
1997
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33. A Prevalidation Study on In Vitro Skin Corrosivity Testing

Author

Botham, Philip A., primary, Chamberlain, Mark, additional, Barratt, Martin D., additional, Curren, Rodger D., additional, Esdaile, David J., additional, Gardner, John R., additional, Gordon, Virginia C., additional, Hildebrand, Bernhard, additional, Lewis, Richard W., additional, Liebsch, Manfred, additional, Logemann, Pamela, additional, Osborne, Rosemarie, additional, Ponec, Maria, additional, Régnier, Jean-Francois, additional, Steiling, Winfried, additional, Walker, Arthur P., additional, and Balls, Michael, additional

Published
1995
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36. Xeroderma pigmentosum fibroblasts are more sensitive to asbestos fibers than are normal human fibroblasts.

Author

Yang, Li L., Kouri, Richard E., and Curren, Rodger D.

Abstract

Xeroderma pigmentosum fibroblasts (XPF) are defective in the repair of certain DNA adducts. We show here that XPF cells are more sensitive to the toxic effects of chrysotile, amosite and crocidolite asbestos than are normal human fibroblasts (NF). XPF cells from different complementation groups have a sensitivity to chrysotile which parallels the degree of their DNA repair deficiency. In addition, the survival of normal cells after chrysotile exposure increases with time if they are kept from replicating, while the survival of XPF cells under the same circumstances does not change. [ABSTRACT FROM PUBLISHER]

Published
1984

37. Evaluation of Some In VitroTests to Reduce and Replace the Sub-acute Animal Toxicity Studies

Author

Chhabra, Rajendra S., Ress, Nancy B., Harbell, John W., and Curren, Rodger D.

Abstract

The toxicologic and carcinogenic potential of chemicals is usually determined through a sequence of acute, sub-acute (14-day), sub-chronic (90-day) and chronic (two-year) studies in rats and mice of both sexes. The US National Toxicology Program (NTP) does not conduct acute toxicity studies. Dose levels for 14-day toxicity studies are typically estimated from information in the literature, if available. The toxicology information obtained from 14-day studies is used in the selection of doses for 90-day studies. The protocol for 14-day studies consists of five doses and control groups and five animals per group of each sex and species, resulting in the use of 120 animals per study. At present, in addition to refining the current testing protocols, the NTP is evaluating the potential for in vitrotest methods to partially or completely avoid the need for 14-day toxicity studies, especially for chemicals where the dermal route of exposure is used. The in vitroassays used were the EpiDerm™ bioassay to estimate dermal irritation, the neutral red uptake (NRU) bioassay to estimate systemic toxicity and the primary rat hepatocyte cytotoxicity (PRHC) assay to estimate hepatotoxicity. The purpose of using these assays was to assess their potential for predicting relative in vivotoxicity and to support dose selection decisions for 90-day studies. In general, based on these limited number of studies, the EpiDerm and NRU tests were predictive of the responses observed in in vivostudies. However, a larger comparative database is needed to derive definitive conclusions regarding the value of in vitrotests in the prediction of in vivoeffects.

Published
2004
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38. Follow-up to the ECVAM Prevalidation Study on In VitroTests for Acute Skin Irritation: ECVAM Skin Irritation Task Force Report 2

Author

Zuang, Valérie, Balls, Michael, Botham, Philip A., Coquette, Alain, Corsini, Emanuela, Curren, Rodger D., Elliott, Graham R., Fentem, Julia H., Heylings, Jon R., Liebsch, Manfred, Medina, Jesús, Roguet, Roland, van de Sandt, Johannes J.M., Wiemann, Christianne, and Worth, Andrew P.

Abstract

The European Centre for the Validation of Alternative Methods (ECVAM) Skin Irritation Task Force was established in 1996, to review the status of the development and validation of alternative tests for skin irritation and corrosion, and to identify appropriate non-animal tests for predicting human skin irritation that were sufficiently well-developed to be prevalidated and validated by ECVAM. The EpiDerm™ method, based on a reconstituted human skin model, was proposed as being sufficiently well advanced to enter a prevalidation (PV) study. Based on a review of test protocols, prediction models (PMs), and data submitted by test developers on ten specified chemicals, with 20% sodium lauryl sulphate as a reference standard, the task force recommended the inclusion of four other tests: EPISKIN™ and PREDISKIN™, based on reconstituted human epidermis or on human skin; the non-perfused pig-ear test, based on pig skin; and the skin integrity function test (SIFT), with ex vivomouse skin. The prevalidation study on these methods was funded by ECVAM, and took place during 1999–2000. The outcome of the PV study was that none of the methods was ready to enter a formal validation study, and that the protocols and PMs of the methods had to be improved in order to increase their predictive abilities. Improved protocols and PMs for the EpiDerm and EPISKIN methods, the pig ear test, and the SIFT were presented at an extended Task Force meeting held in May 2001. It was agreed that, in the short term, the performance of the revised and harmonised EpiDerm and EPISKIN methods, as well as the modified SIFT, should be evaluated in a further study with a new set of 20 test chemicals. In addition, it was decided that the SIFT and the pig-ear test would be compared to see if common endpoints (transepidermal water loss, methyl green-pyronine stain) could be identified.

Published
2002
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