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4. The Thousand Faces of Invasive Group A Streptococcal Infections: Update on Epidemiology, Symptoms, and Therapy

Author

Mercadante, Stefania, primary, Ficari, Andrea, additional, Romani, Lorenza, additional, De Luca, Maia, additional, Tripiciano, Costanza, additional, Chiurchiù, Sara, additional, Calo Carducci, Francesca Ippolita, additional, Cursi, Laura, additional, Di Giuseppe, Martina, additional, Krzysztofiak, Andrzej, additional, Bernardi, Stefania, additional, and Lancella, Laura, additional

Published
2024
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6. Monocyte‐to‐lymphocyte, neutrophil‐to‐lymphocyte and neutrophil‐to‐monocyte plus lymphocyte ratios in children with active tuberculosis: A multicentre study

Author

Cursi, Laura, primary, Lancella, Laura, additional, Mariani, Francesco, additional, Martino, Laura, additional, Leccese, Bianca, additional, Di Giuseppe, Martina, additional, Venuti, Francesco, additional, Cristina, Russo, additional, Gentile, Leonarda, additional, Sali, Michela, additional, Delogu, Giovanni, additional, Valentini, Piero, additional, and Buonsenso, Danilo, additional

Published
2023
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8. Pediatric COVID-TB: A Clinical Perspective Based on the Analysis of Three Cases

Author

Leone, Fabrizio, primary, Di Giuseppe, Martina, additional, De Luca, Maia, additional, Cursi, Laura, additional, Calo Carducci, Francesca Ippolita, additional, Krzysztofiak, Andrzej, additional, Chiurchiù, Sara, additional, Romani, Lorenza, additional, Russo, Cristina, additional, Lancella, Laura, additional, and Bernardi, Stefania, additional

Published
2023
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9. The Prevalence of Carbapenemase-Producing Microorganisms and Use of Novel Cephalosporins for the Treatment of Severe Infections Caused by Carbapenem-Resistant Gram-Negative Bacteria in a Pediatric Cardiac Intensive Care Unit

Author

Tripiciano, Costanza, primary, Romani, Lorenza, additional, Mercadante, Stefania, additional, Cursi, Laura, additional, Di Giuseppe, Martina, additional, Calo Carducci, Francesca Ippolita, additional, Fragasso, Tiziana, additional, Di Chiara, Luca, additional, Garisto, Cristiana, additional, Sisto, Annamaria, additional, Vallesi, Leonardo, additional, Costabile, Valentino, additional, Lancella, Laura, additional, Bernaschi, Paola, additional, and De Luca, Maia, additional

Published
2023
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12. Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Author

Buonsenso, Danilo, primary, Noguera-Julian, Antoni, additional, Moroni, Rossana, additional, Hernández-Bartolomé, Angel, additional, Fritschi, Nora, additional, Lancella, Laura, additional, Cursi, Laura, additional, Soler-Garcia, Aleix, additional, Krüger, Renate, additional, Feiterna-Sperling, Cornelia, additional, Sali, Michela, additional, Lo Vecchio, Andrea, additional, Scarano, Sara, additional, Hernanz Lobo, Alicia, additional, Espiau, Maria, additional, Soriano-Arandes, Antonio, additional, Cetin, Benhur Sirvan, additional, Brinkmann, Folke, additional, Ozere, Iveta, additional, Baquero-Artigao, Fernando, additional, Tsolia, Maria, additional, Milheiro Silva, Tiago, additional, Bustillo-Alonso, Matilde, additional, Martín Nalda, Andrea, additional, Mancini, Margherita, additional, Starshinova, Anna, additional, Ritz, Nicole, additional, Velizarova, Svetlana, additional, Ferreras-Antolín, Laura, additional, Götzinger, Florian, additional, Bilogortseva, Olga, additional, Chechenyeva, Vira, additional, Tebruegge, Marc, additional, and Santiago-García, Begoña, additional

Published
2022
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13. One Year of Lung Ultrasound in Children with SARS-CoV-2 Admitted to a Tertiary Referral Children’s Hospital: A Retrospective Study during 2020–2021

Author

Musolino, Anna Maria, primary, Ferro, Valentina, additional, Supino, Maria Chiara, additional, Boccuzzi, Elena, additional, Scateni, Simona, additional, Sinibaldi, Serena, additional, Cursi, Laura, additional, Schingo, Paolo Maria Salvatore, additional, Reale, Antonino, additional, Campana, Andrea, additional, Raponi, Massimiliano, additional, Villani, Alberto, additional, and Tomà, Paolo, additional

Published
2022
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14. Clostridioides difficile Infection in Children: A 5-Year Multicenter Retrospective Study

Author

Buonsenso, Danilo, primary, Graffeo, Rosalia, additional, Pata, Davide, additional, Valentini, Piero, additional, Palumbo, Carla, additional, Masucci, Luca, additional, Ruggiero, Antonio, additional, Attinà, Giorgio, additional, Onori, Manuela, additional, Lancella, Laura, additional, Lucignano, Barbara, additional, Giuseppe, Martina Di, additional, Bernaschi, Paola, additional, and Cursi, Laura, additional

Published
2022
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15. Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study.

Author

Buonsenso, Danilo, Noguera-Julian, Antoni, Moroni, Rossana, Hernández-Bartolomé, Angel, Fritschi, Nora, Lancella, Laura, Cursi, Laura, Soler-Garcia, Aleix, Krüger, Renate, Feiterna-Sperling, Cornelia, Sali, Michela, Lo Vecchio, Andrea, Scarano, Sara, Hernanz Lobo, Alicia, Espiau, Maria, Soriano-Arandes, Antonio, Sirvan Cetin, Benhur, Brinkmann, Folke, Ozere, Iveta, and Baquero-Artigao, Fernando

Subjects
TUBERCULOUS meningitis, LATENT tuberculosis, TUBERCULOSIS, HIV infections, JUVENILE diseases
Abstract

Rationale: In 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB).Objectives: This study aimed to determine the performance of QFT-Plus, compared with previous generation IGRAs and the tuberculin skin test (TST), in children with TB in Europe.Methods: Multicentre, ambispective cohort study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), a dedicated paediatric TB research network comprising >300 members, capturing TB cases <18 years-of-age diagnosed between January 2009 and December 2019.Measurements and Main Results: 1001 TB cases from 16 countries were included (mean age (IQR) 5.6 (2.4-12.1) years). QFT-Plus was performed in 358, QFT Gold in-Tube (QFT-GIT) in 600, T-SPOT.TB in 58 and TST in 636 cases. The overall test sensitivities were: QFT-Plus 83.8% (95% CI 80.2% to 87.8%), QFT-GIT 85.5% (95% CI 82.7% to 88.3%), T-SPOT.TB 77.6% (95% CI 66.9% to 88.3%) and TST (cut-off ≥10 mm) 83.3% (95% CI 83.3% to 86.2%). There was a trend for tests to have lower sensitivity in patients with miliary and/or central nervous system (CNS) TB (73.1%, 70.9%, 63.6% and 43.5%, respectively), and in immunocompromised patients (75.0%, 59.6%, 45.5% and 59.1%, respectively).Conclusions: The results indicate that the latest generation IGRA assay, QFT-Plus, does not perform better than previous generation IGRAs or the TST in children with TB disease. Overall, tests performed worse in CNS and miliary TB, and in immunocompromised children. None of the tests evaluated had sufficiently high sensitivity to be used as a rule-out test in children with suspected TB. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Safety of Monoclonal Antibodies in Children Affected by SARS-CoV-2 Infection

Author

Romani, Lorenza, primary, Calò Carducci, Francesca Ippolita, additional, Chiurchiù, Sara, additional, Cursi, Laura, additional, De Luca, Maia, additional, Di Giuseppe, Martina, additional, Krzysztofiak, Andrzej, additional, Lancella, Laura, additional, Palma, Paolo, additional, Vallesi, Leonardo, additional, Corsetti, Tiziana, additional, Campana, Andrea, additional, Nicastri, Emanuele, additional, Rossi, Paolo, additional, and Bernardi, Stefania, additional

Published
2022
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17. Severe COVID-19 Complicated by Cerebral Venous Thrombosis in a Newborn Successfully Treated with Remdesivir, Glucocorticoids, and Hyperimmune Plasma

Author

Cursi, Laura, primary, Calo Carducci, Francesca Ippolita, additional, Chiurchiu, Sara, additional, Romani, Lorenza, additional, Stoppa, Francesca, additional, Lucignani, Giulia, additional, Russo, Cristina, additional, Longo, Daniela, additional, Perno, Carlo Federico, additional, Cecchetti, Corrado, additional, Lombardi, Mary Haywood, additional, D’Argenio, Patrizia, additional, Lancella, Laura, additional, Bernardi, Stefania, additional, and Rossi, Paolo, additional

Published
2021
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18. One year of Lung Ultrasound in children with SarsCoV2 infection admitted to a tertiary referral children’s hospital: a retrospective, single-center study, during 2020-2021 period.

Author

Musolino, Anna Maria, primary, Ferro, Valentina, additional, Supino, Maria Chiara, additional, Boccuzzi, Elena, additional, Scateni, Simona, additional, Sinibaldi, Serena, additional, Cursi, Laura, additional, Schingo, Paolo Maria, additional, Reale, Antonino, additional, Campana, Andrea, additional, Raponi, Massimiliano, additional, Villani, Alberto, additional, and Toma, Paolo, additional

Published
2021
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20. VIROLOGICAL AND IMMUNOLOGICAL FEATURES OF SARS-COV-2 INFECTED CHILDREN WITH DISTINCT SYMPTOMATOLOGY

Author

Cotugno, Nicola, primary, Ruggiero, Alessandra, additional, Pascucci, Giuseppe, additional, Bonfante, Francesco, additional, Petrara, Maria, additional, Zicari, Sonia, additional, Cifaldi, Loredana, additional, Zangari, Paola, additional, Bernardi, Stefania, additional, Cursi, Laura, additional, Medri, Chiara, additional, Santilli, Veronica, additional, Manno, Emma, additional, Amodio, Donato, additional, Linardos, Giulia, additional, Piccioni, Livia, additional, Barbieri, Maria, additional, Perrotta, Daniela, additional, Campana, Andrea, additional, Donà, Daniele, additional, Giaquinto, Carlo, additional, Team, Cactus Study, additional, Concato, Carlo, additional, Brodin, Petter, additional, Rossi, Paolo, additional, Rossi, Anita De, additional, and Palma, Paolo, additional

Published
2021
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21. Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies

Author

Cotugno, Nicola, primary, Ruggiero, Alessandra, additional, Bonfante, Francesco, additional, Petrara, Maria Raffaella, additional, Zicari, Sonia, additional, Pascucci, Giuseppe Rubens, additional, Zangari, Paola, additional, De Ioris, Maria Antonietta, additional, Santilli, Veronica, additional, Manno, E.C., additional, Amodio, Donato, additional, Bortolami, Alessio, additional, Pagliari, Matteo, additional, Concato, Carlo, additional, Linardos, Giulia, additional, Campana, Andrea, additional, Donà, Daniele, additional, Giaquinto, Carlo, additional, Brodin, Petter, additional, Rossi, Paolo, additional, De Rossi, Anita, additional, Palma, Paolo, additional, Bernardi, Stefania, additional, Romani, Lorenza, additional, Pansa, Paola, additional, Chiurchiú, Sara, additional, Finocchi, Andrea, additional, Cancrini, Caterina, additional, Lancella, Laura, additional, Cursi, Laura, additional, De Luca, Maia, additional, Cutrera, Renato, additional, Sessa, Libera, additional, Morrocchi, Elena, additional, Medri, Chiara, additional, Putignani, Lorenza, additional, Calò Carducci, F.I., additional, D’Argenio, Patrizia, additional, Ciofi degli Atti, Marta, additional, D’Amore, Carmen, additional, Piccioni, Livia, additional, Di Giuseppe, Martina, additional, Jenkner, Alessandro, additional, Giancotta, Carmela, additional, and Krzysztofiak, Andrzej, additional

Published
2021
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25. Virological and immunological features of SARS‐COV‐2 infected children with distinct symptomatology.

Author

Cotugno, Nicola, Ruggiero, Alessandra, Pascucci, Giuseppe Rubens, Bonfante, Francesco, Petrara, Maria Raffaella, Pighi, Chiara, Cifaldi, Loredana, Zangari, Paola, Bernardi, Stefania, Cursi, Laura, Santilli, Veronica, Manno, Emma Concetta, Amodio, Donato, Linardos, Giulia, Piccioni, Livia, Barbieri, Maria Antonietta, Perrotta, Daniela, Campana, Andrea, Donà, Daniele, and Giaquinto, Carlo

Subjects
SARS-CoV-2, BLOOD proteins, SYMPTOMS, HERD immunity, IMMUNOGLOBULIN G
Abstract

Background: Although SARS‐CoV‐2 immunizations have started in most countries, children are not currently included in the vaccination programs; thus, it remains crucial to define their anti‐SARS‐CoV‐2 immune response in order to minimize the risk for other epidemic waves. This study sought to provide a description of the virology ad anti‐SARS‐CoV‐2 immunity in children with distinct symptomatology. Methods: Between March and July 2020, we recruited 15 SARS‐CoV‐2 asymptomatic (AS) and 51 symptomatic (SY) children, stratified according to WHO clinical classification. We measured SARS‐CoV‐2 viral load using ddPCR and qPCR in longitudinally collected nasopharyngeal swab samples. To define anti‐SARS‐CoV‐2 antibodies, we measured neutralization activity and total IgG load (DiaSorin). We also evaluated antigen‐specific B and CD8+T cells, using a labeled S1+S2 protein and ICAM expression, respectively. Plasma protein profiling was performed with Olink. Results: Virological profiling showed that AS patients had lower viral load at diagnosis (p =.004) and faster virus clearance (p =.0002) compared with SY patients. Anti‐SARS‐CoV‐2 humoral and cellular response did not appear to be associated with the presence of symptoms. AS and SY patients showed similar titers of SARS‐CoV‐2 IgG, levels of neutralizing activity, and frequency of Ag‐specific B and CD8+ T cells, whereas pro‐inflammatory plasma protein profile was found to be associated with symptomatology. Conclusion: We demonstrated the development of anti‐SARS‐CoV‐2 humoral and cellular response with any regard to symptomatology, suggesting the ability of both SY and AS patients to contribute toward herd immunity. The virological profiling of AS patients suggested that they have lower virus load associated with faster virus clearance. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Recommendations Concerning the First-Line Treatment of Children with Tuberculosis

Author

Principi, Nicola, Galli, Luisa, Lancella, Laura, Tadolini, Marina, Migliori, Giovanni Battista, Villani, Alberto, Esposito, Susanna, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, Vecchio, Andrea Lo, Scotto, Riccardo, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, D'Ambrosio, Lia, Centis, Rosella, Cirillo, Daniela, Tortoli, Enrico, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Bocchino, Marialuisa, Matteelli, Alberto, Scaglione, Francesco, LO VECCHIO, ANDREA, BOCCHINO, MARIALUISA, Principi, Nicola, Galli, Luisa, Lancella, Laura, Tadolini, Marina, Migliori, Giovanni Battista, Villani, Alberto, Esposito, Susanna, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, Vecchio, Andrea Lo, Scotto, Riccardo, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, D'Ambrosio, Lia, Centis, Rosella, Cirillo, Daniela, Tortoli, Enrico, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Matteelli, Alberto, Scaglione, Francesco, LO VECCHIO, Andrea, For the Italian Pediatric TB Study Group, Null, and DI COMITE, Amelia

Subjects
0301 basic medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, Tuberculosi, 030106 microbiology, Drug Resistance, Breastfeeding, Antitubercular Agents, Child, Drug Resistance, Microbial, Humans, Isoniazid, Medication Adherence, Tuberculosis, Pulmonary, Tuberculous meningitis, 03 medical and health sciences, Antitubercular Agent, Microbial, 0302 clinical medicine, Pharmacotherapy, 030225 pediatrics, medicine, Pharmacology (medical), Adverse effect, Ethambutol, Perinatology and Child Health, business.industry, Tuberculous pericarditis, Pulmonary, Pyrazinamide, medicine.disease, Settore MED/38, Surgery, Pediatrics, Perinatology and Child Health, business, medicine.drug, Human
Abstract

This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.

Published
2016

27. MILD ENCEPHALOPATHY WITH A REVERSIBLE SPLENIAL LESION, A DIFFERENZIAL DIAGNOSIS TO CONSIDER IN CHILDREN

Author

Cursi, Laura

Abstract

Mild Encephalopathy with a Reversible Splenial lesion, a differenzial diagnosis to consider in children Background Mild Encephalopathy with a Reversible Splenial lesion (MERS) is an uncommon clinical-radiological entity characterized by magnetic resonance imaging (MRI) findings of a reversible lesion in the splenium of corpus callosum associated with significant neurological manifestation of encephalopathy. We report three cases of children with different clinical and radiological presentation, associated to an infection.Case Presentation Summary The first case is a 14 years old girl admitted for malaise, fever, headache and later a worsening of neurological aspect with confusion, psychomotor crisis, urinary and fecal retention. Laboratory tests showed hyponatremia and HHV6 infection. Anomalies were evident to electroencephalogram (EEG) and somatosensory evoked potentials (SEEP). The brain MRI showed lesions in the corpus callosum at the splenium level.The second patient is a 3 years old boy admitted for fever, hyponatremia and hypoglicemia. Neurological examination showed poor mental status, lethargy with absence of lower limb tendon reflexes. Cranial MRI showed a focal lesion in the splenium of the corpus callosum. The electroencephalogram (EEG) revealed diffuse slow waves. Pharyngeal swab PCR was positive for Influenza B. The third case is a 11 years old female admitted to our department because of fever, strabismus of the left eye and diplopia. Neuro-ophtalmologic evaluation was normal. Cranial MRI revealed the presence of high signal lesion in the splenium of corpus callosum. The laboratory tests showed HHV6 infections. Learning Points/Discussion MERS is an important differential diagnosis to consider in children presenting with acute encephalopathy/encephalitis. In our experience, patientu2019s symptoms recovered quickly and the splenial lesion disappeared, as described in literature. MERS in clinical practice is very low, but knowledges about its existence are essential to suspect and manage it.

Published
2017

28. How to manage children who have come into contact with patients affected by tuberculosis

Author

Lancella, Laura, Vecchio, Andrea Lo, Chiappini, Elena, Tadolini, Marina, Cirillo, Daniela, Tortoli, Enrico, de Martino, Maurizio, Guarino, Alfredo, Principi, Nicola, Villani, Alberto, Esposito, Susanna, Galli, Luisa, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, Scotto, Riccardo, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Russo, Cristina, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, BOCCHINO, MARIALUISA, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, Matteelli, Alberto, Migliori, Giovanni Battista, Centis, Rossella, D'Ambrosio, Lia, Pasinato, Angela, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Lancella, Laura, Vecchio, Andrea Lo, Chiappini, Elena, Tadolini, Marina, Cirillo, Daniela, Tortoli, Enrico, de Martino, Maurizio, Guarino, Alfredo, Principi, Nicola, Villani, Alberto, Esposito, Susanna, Galli, Luisa, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, Scotto, Riccardo, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Russo, Cristina, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, Matteelli, Alberto, Migliori, Giovanni Battista, Centis, Rossella, D'Ambrosio, Lia, Pasinato, Angela, Scaglione, Franco, Scala, Elisabetta, and Tomà, Paolo

Subjects
Pulmonary and Respiratory Medicine, Microbiology (medical), Pediatrics, medicine.medical_specialty, Tuberculosis, Contacts, Tuberculosi, IGRA, LTBI, Multidrug-resistant tuberculosis, Mycobacterium tuberculosis, Disease, Mycobacterium tuberculosi, Article, lcsh:Infectious and parasitic diseases, Molecular typing, Contact, Medicine, lcsh:RC109-216, Index case, lcsh:RC705-779, Immune status, biology, business.industry, Transmission (medicine), lcsh:Diseases of the respiratory system, biology.organism_classification, medicine.disease, Multidrug-resistant tuberculosi, Infectious Diseases, Chemoprophylaxis, Immunology, business
Abstract

Childhood tuberculosis (TB) indicates a recent infection, particularly in children aged

Published
2015

30. Acute cerebellitis in children: an eleven year retrospective multicentric study in Italy

Author

Lancella, Laura, primary, Esposito, Susanna, additional, Galli, Maria Luisa, additional, Bozzola, Elena, additional, Labalestra, Valeria, additional, Boccuzzi, Elena, additional, Krzysztofiak, Andrzej, additional, Cursi, Laura, additional, Gattinara, Guido Castelli, additional, Mirante, Nadia, additional, Buonsenso, Danilo, additional, Tagliabue, Claudia, additional, Castellazzi, Luca, additional, Montagnani, Carlotta, additional, Tersigni, Chiara, additional, Valentini, Piero, additional, Capozza, Michele, additional, Pata, Davide, additional, Di Gangi, Maria, additional, Dones, Piera, additional, Garazzino, Silvia, additional, Baroero, Luca, additional, Verrotti, Alberto, additional, Melzi, Maria Luisa, additional, Sacco, Michele, additional, Germano, Michele, additional, Greco, Filippo, additional, Uga, Elena, additional, Crichiutti, Giovanni, additional, and Villani, Alberto, additional

Published
2017
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31. 72nd Congress of the Italian Society of Pediatrics

Author

Braghero, Marco, primary, Staiano, Annamaria, additional, Biasin, Eleonora, additional, Matarazzo, Patrizia, additional, Einaudi, Silvia, additional, Manicone, Rosaria, additional, Felicetti, Francesco, additional, Brignardello, Enrico, additional, Fagioli, Franca, additional, Bignamini, Elisabetta, additional, Nave, Elena, additional, Callea, F., additional, Concato, C., additional, Fiscarelli, E., additional, Garrone, S., additional, de Gasperis, M.Rossi, additional, Calzi, Patrizia, additional, Marinelli, Grazia, additional, Besana, Roberto, additional, Caffarelli, Carlo, additional, Di Peri, Antonio, additional, Lapetina, Irene, additional, Cincinnati, Patrizia, additional, Da Riol, Rosalia Maria, additional, De Curtis, Mario, additional, Dito, Lucia, additional, Protano, Chiara, additional, Esposito, Susanna, additional, Ferrara, Dante, additional, Galiano, Rossella, additional, Novellino, Pasquale, additional, Kossoff, Eric Heath, additional, Krzysztofiak, Andrzej, additional, Bozzola, Elena, additional, Lancella, Laura, additional, Marchesi, Alessandra, additional, Villani, Alberto, additional, Lago, Paola, additional, Garetti, Elisabetta, additional, Pirelli, Anna, additional, Marchisio, Paola, additional, Santagati, Maria, additional, Stefani, Stefania, additional, Principi, Nicola, additional, d’Apolito, Valeria, additional, Memo, Luigi, additional, Selicorni, Angelo, additional, Miniello, Vito Leonardo, additional, Diaferio, Lucia, additional, Palmieri, Antonella, additional, Parola, Luciana, additional, Piro, Ettore, additional, Romano, Claudio, additional, Catena, Maria Ausilia, additional, Cardile, Sabrina, additional, Sacco, Oliviero, additional, Girosi, Donata, additional, Olcese, Roberta, additional, Tosca, Mariangela, additional, Rossi, Giovanni Arturo, additional, Salerno, Sergio, additional, Terranova, Maria Chiara, additional, Santamaria, Francesca, additional, Mancano, Giorgia, additional, Maitz, Silvia, additional, Stallings, Virginia A., additional, Berlolaso, Chiara, additional, McAnlis, Carolyn, additional, Schall, Joan I., additional, Striano, Pasquale, additional, Tanas, Rita, additional, De Iaco, Giulia, additional, Marsella, Maria, additional, Caggese, Guido, additional, Toma, Paolo, additional, Valentini, Piero, additional, Buonsenso, Danilo, additional, Pata, David, additional, Ceccarelli, Manuela, additional, Verduci, Elvira, additional, Brambilla, Marta, additional, Mariani, Benedetta, additional, Lassandro, Carlotta, additional, Dionigi, Alice Re, additional, Vizzuso, Sara, additional, Banderali, Giuseppe, additional, Panzarino, Gianvito, additional, Di Paolantonio, Claudia, additional, Verrotti, Alberto, additional, Cursi, Laura, additional, Grandin, Annalisa, additional, Virdis, Raffaele, additional, Carletti, Patrizia, additional, Weber, Giovanna, additional, Caiulo, Silvana, additional, and Vigone, Maria Cristina, additional

Published
2017
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32. NK cell effector functions in a Chédiak-Higashi patient undergoing cord blood transplantation: Effects of in vitro treatment with IL-2

Author

Cifaldi, Loredana, primary, Pinto, Rita Maria, additional, Rana, Ippolita, additional, Caniglia, Maurizio, additional, Angioni, Adriano, additional, Petrocchi, Stefano, additional, Cancrini, Caterina, additional, Cursi, Laura, additional, Palumbo, Giuseppe, additional, Zingoni, Alessandra, additional, Gismondi, Angela, additional, Rossi, Paolo, additional, Santoni, Angela, additional, and Cerboni, Cristina, additional

Published
2016
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34. Carbapenem-resistant Enterobacteriaceae Infections in Children

Author

Montagnani, Carlotta, primary, Prato, Manuela, additional, Scolfaro, Carlo, additional, Colombo, Sara, additional, Esposito, Susanna, additional, Tagliabue, Claudia, additional, Lo Vecchio, Andrea, additional, Bruzzese, Eugenia, additional, Loy, Anna, additional, Cursi, Laura, additional, Vuerich, Marco, additional, de Martino, Maurizio, additional, and Galli, Luisa, additional

Published
2016
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35. Pediatric Tuberculosis in Italian Children: Epidemiological and Clinical Data from the Italian Register of Pediatric Tuberculosis

Author

Galli, Luisa, primary, Lancella, Laura, additional, Tersigni, Chiara, additional, Venturini, Elisabetta, additional, Chiappini, Elena, additional, Bergamini, Barbara, additional, Codifava, Margherita, additional, Venturelli, Cristina, additional, Tosetti, Giulia, additional, Marabotto, Caterina, additional, Cursi, Laura, additional, Boccuzzi, Elena, additional, Garazzino, Silvia, additional, Tovo, Pier, additional, Pinon, Michele, additional, Le Serre, Daniele, additional, Castiglioni, Laura, additional, Lo Vecchio, Andrea, additional, Guarino, Alfredo, additional, Bruzzese, Eugenia, additional, Losurdo, Giuseppe, additional, Castagnola, Elio, additional, Bossi, Grazia, additional, Marseglia, Gian, additional, Esposito, Susanna, additional, Bosis, Samantha, additional, Grandolfo, Rita, additional, Fiorito, Valentina, additional, Valentini, Piero, additional, Buonsenso, Danilo, additional, Domenici, Raffaele, additional, Montesanti, Marco, additional, Salvini, Filippo, additional, Riva, Enrica, additional, Dodi, Icilio, additional, Maschio, Francesca, additional, Abbagnato, Luisa, additional, Fiumana, Elisa, additional, Fornabaio, Chiara, additional, Ballista, Patrizia, additional, Portelli, Vincenzo, additional, Bottone, Gabriella, additional, Palladino, Nicola, additional, Valenzise, Mariella, additional, Vecchi, Barbara, additional, Di Gangi, Maria, additional, Lupi, Carla, additional, Villani, Alberto, additional, and de Martino, Maurizio, additional

Published
2016
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37. Optimal Thalassemia Free Survival and Minimal Regimen Related Toxicity in 50 Consecutive Transplants of High Risk Beta Thalassemia Pediatric Patients Using Myelablative Therapy with Intravenous Busulphan.

Author

Marktel, Sarah, primary, Chiesa, Robert, additional, Cappelli, Barbara, additional, Roccia, Tito, additional, Frugnoli, Ilaria, additional, Noè, Anna, additional, Biral, Erika, additional, Crocchiolo, Roberto, additional, Evangelio, Costanza, additional, Fossati, Marco, additional, Napolitano, Sara, additional, Soliman, Clara, additional, Cursi, Laura, additional, Cattaneo, Federica, additional, Zito, Laura, additional, Fiori, Rossana, additional, Fleischhauer, Katharina, additional, Miniero, Roberto, additional, Ciceri, Fabio, additional, and Roncarolo, Maria Grazia, additional

Published
2008
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39. 72nd Congress of the Italian Society of Pediatrics

Author

Braghero, Marco, Staiano, Annamaria, Biasin, Eleonora, Matarazzo, Patrizia, Einaudi, Silvia, Manicone, Rosaria, Felicetti, Francesco, Brignardello, Enrico, Fagioli, Franca, Bignamini, Elisabetta, Nave, Elena, Callea, F., Concato, C., Fiscarelli, E., Garrone, S., de Gasperis, M.Rossi, Calzi, Patrizia, Marinelli, Grazia, Besana, Roberto, Caffarelli, Carlo, Di Peri, Antonio, Lapetina, Irene, Cincinnati, Patrizia, Da Riol, Rosalia Maria, De Curtis, Mario, Dito, Lucia, Protano, Chiara, Esposito, Susanna, Ferrara, Dante, Galiano, Rossella, Novellino, Pasquale, Kossoff, Eric Heath, Krzysztofiak, Andrzej, Bozzola, Elena, Lancella, Laura, Marchesi, Alessandra, Villani, Alberto, Lago, Paola, Garetti, Elisabetta, Pirelli, Anna, Marchisio, Paola, Santagati, Maria, Stefani, Stefania, Principi, Nicola, d’Apolito, Valeria, Memo, Luigi, Selicorni, Angelo, Miniello, Vito Leonardo, Diaferio, Lucia, Palmieri, Antonella, Parola, Luciana, Piro, Ettore, Romano, Claudio, Catena, Maria Ausilia, Cardile, Sabrina, Sacco, Oliviero, Girosi, Donata, Olcese, Roberta, Tosca, Mariangela, Rossi, Giovanni Arturo, Salerno, Sergio, Terranova, Maria Chiara, Santamaria, Francesca, Mancano, Giorgia, Maitz, Silvia, Stallings, Virginia A., Berlolaso, Chiara, McAnlis, Carolyn, Schall, Joan I., Striano, Pasquale, Tanas, Rita, De Iaco, Giulia, Marsella, Maria, Caggese, Guido, Toma, Paolo, Valentini, Piero, Buonsenso, Danilo, Pata, David, Ceccarelli, Manuela, Verduci, Elvira, Brambilla, Marta, Mariani, Benedetta, Lassandro, Carlotta, Dionigi, Alice Re, Vizzuso, Sara, Banderali, Giuseppe, Panzarino, Gianvito, Di Paolantonio, Claudia, Verrotti, Alberto, Cursi, Laura, Grandin, Annalisa, Virdis, Raffaele, Carletti, Patrizia, Weber, Giovanna, Caiulo, Silvana, and Vigone, Maria Cristina

Subjects
Meeting Abstracts
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40. Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Author

Danilo, Buonsenso, Antoni, Noguera-Julian, Rossana, Moroni, Angel, Hernández-Bartolomé, Nora, Fritschi, Laura, Lancella, Laura, Cursi, Aleix, Soler-Garcia, Renate, Krüger, Cornelia, Feiterna-Sperling, Michela, Sali, Andrea, Lo Vecchio, Sara, Scarano, Alicia, Hernanz Lobo, Maria, Espiau, Antonio, Soriano-Arandes, Benhur Sirvan, Cetin, Folke, Brinkmann, Iveta, Ozere, Fernando, Baquero-Artigao, Maria, Tsolia, Tiago, Milheiro Silva, Matilde, Bustillo-Alonso, Andrea, Martín Nalda, Margherita, Mancini, Anna, Starshinova, Nicole, Ritz, Svetlana, Velizarova, Laura, Ferreras-Antolín, Florian, Götzinger, Olga, Bilogortseva, Vira, Chechenyeva, Marc, Tebruegge, Begoña, Santiago-García, Cristina, Russo, Buonsenso, Danilo, Noguera-Julian, Antoni, Moroni, Rossana, Hernández-Bartolomé, Angel, Fritschi, Nora, Lancella, Laura, Cursi, Laura, Soler-Garcia, Aleix, Krüger, Renate, Feiterna-Sperling, Cornelia, Sali, Michela, Lo Vecchio, Andrea, Scarano, Sara, Hernanz Lobo, Alicia, Espiau, Maria, Soriano-Arandes, Antonio, Cetin, Benhur Sirvan, Brinkmann, Folke, Ozere, Iveta, Baquero-Artigao, Fernando, Tsolia, Maria, Milheiro Silva, Tiago, Bustillo-Alonso, Matilde, Martín Nalda, Andrea, Mancini, Margherita, Starshinova, Anna, Ritz, Nicole, Velizarova, Svetlana, Ferreras-Antolín, Laura, Götzinger, Florian, Bilogortseva, Olga, Chechenyeva, Vira, Tebruegge, Marc, and Santiago-García, Begoña

Subjects
Pulmonary and Respiratory Medicine, Tuberculosis, Children, Diagnosis, Quantiferon
Abstract

RationaleIn 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB).ObjectivesThis study aimed to determine the performance of QFT-Plus, compared with previous generation IGRAs and the tuberculin skin test (TST), in children with TB in Europe.MethodsMulticentre, ambispective cohort study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), a dedicated paediatric TB research network comprising >300 members, capturing TB cases Measurements and main results1001 TB cases from 16 countries were included (mean age (IQR) 5.6 (2.4–12.1) years). QFT-Plus was performed in 358, QFT Gold in-Tube (QFT-GIT) in 600, T-SPOT.TBin 58 and TST in 636 cases. The overall test sensitivities were: QFT-Plus 83.8% (95% CI 80.2% to 87.8%), QFT-GIT 85.5% (95% CI 82.7% to 88.3%), T-SPOT.TB77.6% (95% CI 66.9% to 88.3%) and TST (cut-off ≥10 mm) 83.3% (95% CI 83.3% to 86.2%). There was a trend for tests to have lower sensitivity in patients with miliary and/or central nervous system (CNS) TB (73.1%, 70.9%, 63.6% and 43.5%, respectively), and in immunocompromised patients (75.0%, 59.6%, 45.5% and 59.1%, respectively).ConclusionsThe results indicate that the latest generation IGRA assay, QFT-Plus, does not perform better than previous generation IGRAs or the TST in children with TB disease. Overall, tests performed worse in CNS and miliary TB, and in immunocompromised children. None of the tests evaluated had sufficiently high sensitivity to be used as a rule-out test in children with suspected TB.

Published
2022

41. Recommendations for treating children with drug-resistant tuberculosis

Author

Galli L., Lancella L., Garazzino S., Tadolini M., Matteelli A., Migliori G. B., Principi N., Villani A., Esposito S. Italian Pediatric TB Study Group: Samantha Bosis, Claudia Tagliabue, Laura Senatore, Beatrice Ascolese, Laura Cursi, Annalisa Grandin, Caterina Marabotto, Maurizio de Martino, Elena Chiappini, Carlotta Montagnani, Daniele Ciofi, Filippo Festini, Martina Anziati, Sabrina Becciani, Giulia Remaschi, Sara Sollai, Chiara Tersigni, Elisabetta Venturini, Alfredo Guarino, Andrea Lo Vecchio, Riccardo Scotto, Fi lippo Bernardi, Elisa Bertazzoni, Francesco Blasi, Marialuisa Bocchino, Luca Assante, Elio Castagnola, Giuseppe Losurdo, Giannina Gaslini, Luigi Codec, Giuseppe Di Mauro, Marino Faccini, Clara Gabiano, Daniele Le Serre, Irene Raffaldi, Regina Margherita, Gianluigi Marseglia, Amelia Mascolo, Mauro Stronati, Rosella Centis, Lia D'Ambrosio, Angela Pasinato, Cristina Russo, Franco Scaglione, Elisabetta Scala, Paolo Tomà, Susanna Esposito, Luisa Galli, Laura Lancella, Nicola Principi, Samantha Bosis, Silvi a Garazzino, Alberto Villani, Filippo Bernardi, Luigi Codecasa, Alberto Matteelli, Enrico Tortoli, Francesco Scaglione, Daniela Cirillo, Giovanni Battista Migliori, Marina Tadolini, L., Galli, L., Lancella, S., Garazzino, M., Tadolini, A., Matteelli, G. B., Migliori, N., Principi, A., Villani, Italian Pediatric TB Study Group: Samantha Bosis, Esposito S., Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, LO VECCHIO, Andrea, Scotto, Riccardo, lippo Bernardi, Fi, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, LUCA ROSARIO, Castagnola, Elio, Losurdo, Giuseppe, Gaslini, Giannina, Codec, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Le Serre, Daniele, Raffaldi, Irene, Margherita, Regina, Marseglia, Gianluigi, Mascolo, Amelia, Stronati, Mauro, Centis, Rosella, D'Ambrosio, Lia, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Esposito, Susanna, Galli, Luisa, Lancella, Laura, Lo Vecchio, Andrea, Principi, Nicola, Bosis, Samantha, a Garazzino, Silvi, Villani, Alberto, Bernardi, Filippo, Assante, Luca, Codecasa, Luigi, Matteelli, Alberto, Tortoli, Enrico, Scaglione, Francesco, Cirillo, Daniela, Battista Migliori, Giovanni, Tadolini, Marina, Garazzino, Silvia, and Migliori, Giovanni Battista

Subjects
0301 basic medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, Extensively Drug-Resistant Tuberculosis, 030106 microbiology, Antitubercular Agents, Pediatric tuberculosi, Anti-tuberculosis drugs, MDR-TB, Mycobacterium tuberculosi, Mycobacterium tuberculosis, 03 medical and health sciences, Therapeutic approach, Antitubercular Agent, 0302 clinical medicine, Tuberculosis, Multidrug-Resistant, Children, Pediatric tuberculosis, XDR-TB, Pharmacology, Humans, Medicine, 030212 general & internal medicine, Adverse effect, Child, Cause of death, biology, business.industry, Anti-tuberculosis drug, Extensively drug-resistant tuberculosis, medicine.disease, biology.organism_classification, Settore MED/38, Systematic review, Infectious disease (medical specialty), Extensively Drug-Resistant Tuberculosi, Practice Guidelines as Topic, business, Human
Abstract

Tuberculosis (TB) is still one of the most difficult infectious diseases to treat, and the second most frequent cause of death due to infectious disease throughout the world. The number of cases of multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB), which are characterised by high mortality rates, is increasing. The therapeutic management of children with MDR- and XDR-TB is complicated by a lack of knowledge, and the fact that many potentially useful drugs are not registered for pediatric use and there are no formulations suitable for children in the first years of life. Furthermore, most of the available drugs are burdened by major adverse events that need to be taken into account, particularly in the case of prolonged therapy. This document describes the recommendations of a group of scientific societies on the therapeutic approach to pediatric MDR- and XDR-TB. On the basis of a systematic literature review and their personal clinical experience, the experts recommend that children with active TB caused by a drug-resistant strain of Mycobacterium tuberculosis should always be referred to a specialised centre because of the complexity of patient management, the paucity of pediatric data, and the high incidence of adverse events due to second-line anti-TB treatment.

Published
2016

42. Carbapenem-resistant enterobacteriaceae infections in children: An Italian retrospective multicenter study

Author

Maurizio de Martino, Marco Vuerich, Claudia Tagliabue, Susanna Esposito, A. Loy, Luisa Galli, Laura Cursi, Manuela Prato, Carlo Scolfaro, Andrea Lo Vecchio, Sara Colombo, Carlotta Montagnani, Eugenia Bruzzese, Montagnani, Carlotta, Prato, Manuela, Scolfaro, Carlo, Colombo, Sara, Esposito, Susanna, Tagliabue, Claudia, LO VECCHIO, Andrea, Bruzzese, Eugenia, Loy, Anna, Cursi, Laura, Vuerich, Marco, De Martino, Maurizio, and Galli, Luisa

Subjects
0301 basic medicine, Male, Microbiology (medical), Pediatrics, medicine.medical_specialty, carbapenem-resistant, children, Enterobacteriaceae, 030106 microbiology, MEDLINE, Carbapenem-resistant enterobacteriaceae, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 030212 general & internal medicine, Child, Retrospective Studies, biology, Enterobacteriaceae Infections, business.industry, Infant, Retrospective cohort study, biology.organism_classification, Anti-Bacterial Agents, Infectious Diseases, Multicenter study, Carbapenems, Italy, Child, Preschool, Pediatrics, Perinatology and Child Health, Observational study, Female, business, Pediatric population
Abstract

BACKGROUND: The spread of carbapenem-resistant Enterobacteriaceae (CRE) is a health problem of major concern. CRE-related infections have significant morbidity and mortality, but data on CRE infection in pediatric population are limited. The aim of this study was to analyze epidemiologic and clinical characteristics, risk factors, therapeutic options and outcome of CRE infections in children in Italy. METHODS: We performed a retrospective, multicenter, observational study of children with confirmed CRE infection or colonization admitted between January 1, 2011, and March 1, 2014, to 7 Italian pediatric centers. RESULTS: Sixty-nine patients presenting 74 CRE infections and/or colonization were included. The most frequently isolated strain was Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Children with CRE infections had longer length of stay in hospital (P < 0.001), duration of disease (P = 0.001) and antimicrobial treatment (P < 0.001) than colonized children. Oncologic/immunosuppressive conditions are one of the factors significantly associated with a fatal outcome among children with CRE infections. CONCLUSIONS: Our study confirms that CRE infections affect mostly children with oncologic diseases and immunosuppression. Controlled studies in large cohorts are needed to evaluate the best therapeutic options and to assess further risk factors influencing outcomes and the survival of pediatric patients with infections caused by CRE.

Published
2016

43. HHV6-related mild encephalopathy with reversible splenial lesion (MERS) presenting with urinary and fecal retention in an Italian adolescent.

Author

Cursi L, Boccuzzi E, Lancella L, Longo D, Figá Talamanca L, Bozzola E, and Villani A

Subjects
Adolescent, Brain Diseases diagnostic imaging, Diffusion Magnetic Resonance Imaging, Female, Humans, Hyponatremia etiology, Prodromal Symptoms, Brain Diseases virology, Constipation etiology, Corpus Callosum diagnostic imaging, Herpesvirus 6, Human, Roseolovirus Infections complications, Urinary Retention etiology
Abstract

Mild encephalopathy with a reversible splenial lesion (MERS) is an uncommon clinico-radiological entity characterized by magnetic resonance imaging (MRI) findings of a reversible lesion in the splenium of corpus callosum associated with a significant neurological manifestation of encephalopathy. The majority of reported cases involve the Asiatic population and are closely associated with infection. We report the case of an adolescent with an HHV6-related MERS presenting with hyponatremia and urinary and fecal retention. To our knowledge, urinary retention is not a constant aspect of the disease and has rarely been described, while fecal retention has never been reported before. Despite the self-limiting nature of the disease, it is mandatory to suspect it for a faster diagnosis and it might be useful to know its rare occurrences in order to better understand its etiopathogenetic mechanisms.

Published
2019

44. Thymidine kinase and deoxycytidine kinase in HIV-infected children.

Author

Falasca F, Maida P, Boni A, Bernardi S, Cursi L, Rizzo B, Antonelli G, Gattinara GC, and Turriziani O

Subjects
Adolescent, Adult, Anti-HIV Agents therapeutic use, Child, Child, Preschool, Female, HIV Infections drug therapy, HIV Infections virology, HIV-1 physiology, Humans, Infant, Male, Zidovudine therapeutic use, Deoxycytidine Kinase metabolism, HIV Infections enzymology, Leukocytes, Mononuclear enzymology, Thymidine Kinase metabolism
Abstract

It has been demonstrated that HIV infection may affect the levels of thymidine kinase (TK) and deoxycytidine kinase (dCK) in peripheral blood mononuclear cells from HIV infected adults. The aim of this study was to examine the effect of HIV infection and/or antiretroviral therapy on the activity of the above enzymes in HIV-infected children. The results showed that an inter-individual variability in TK and dCK activities does exist in both HIV infected and uninfected children. TK and dCK levels in PBMC from HIV infected and non infected children did not significantly differ. Furthermore, the therapeutic regimen, including zidovudine, does not seem to affect TK activity.

Published
2009

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