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Two studies investigated relationships between the negative symptoms of schizophrenia (e.g., flattened emotions and poverty of speech), depression, and tardive dyskinesia (a movement disorder associated with the long-term use of antipsychotic medication). In the first study 222 long-term, nongeriatric schizophrenic patients were administered tests to assess depressive disorder. Depression was found in 25 (13 percent) of the patients who were then matched for sex, age, and illness chronicity with 25 patients (controls) rated as nondepressed. Both groups were reassessed for depression and given tests to evaluate negative symptoms and tardive dyskinesia at one-week and three-month follow-up sessions. No significant differences were found between depressed and nondepressed groups on tardive dyskinesia and negative symptom ratings. In the second study, 56 long-term schizophrenic patients took tests to measure negative symptoms, tardive dyskinesia, depression and akathisia (motor restlessness). Thirty-seven patients were found to have orofacial dyskinesia (bizarre face, tongue and neck movements). The presence of orofacial dyskinesia was significantly related to illness chronicity and four negative symptoms: emotional flattening, poverty of speech, psychomotor retardation, and aphasia (difficulty communicating). The average age for the onset of dyskinesia among patients with negative symptoms was 46 years, while the average age of onset for patients without negative symptoms was 59 years. Findings suggest a causal link in the pathology of negative symptoms and abnormal movements and indicate that depression and negative symptoms are unrelated clinical syndromes. (Consumer Summary produced by Reliance Medical Information, Inc.)