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2 results on '"Curtis Bartz"'

1. Comparison of the efficacy of AZT and PMEA treatment against acute SIVmne infection in macaques

Author

Norbert Bischofberger, Randolph E. Nolte, Richard Grant, Raoul E. Benveniste, Curtis Bartz, Kathryn E. Follis, Che-Chung Tsai, and Alexander Sabo

Subjects
Drug, Time Factors, viruses, media_common.quotation_subject, Organophosphonates, Simian Acquired Immunodeficiency Syndrome, medicine.disease_cause, Antiviral Agents, Polymerase Chain Reaction, Virus, Drug treatment, medicine, Animals, Virus load, media_common, General Veterinary, biology, Inoculation, business.industry, Adenine, Simian immunodeficiency virus, Macaca mulatta, Virology, Lymphocyte Subsets, DNA, Viral, Splenomegaly, Immunology, biology.protein, Simian Immunodeficiency Virus, Animal Science and Zoology, Antibody, business, Zidovudine
Abstract

The antiretroviral drugs azidothymidine (AZT) and 9-(-2-phosphonyl-methoxyethyl)adenine (PMEA) were individually tested for prevention of simian immunodeficiency virus (SIVmne) infection in macaques (Macaca fascicularis). Macaques were pretreated with either drug before inoculation with SIVmne, and drug treatment was continued for four weeks. The virus, antibody, and clinical status of the macaques was monitored for up to 36 weeks following inoculation. While AZT prophylaxis resulted in reduced virus load in some macaques, PMEA prophylaxis was highly efficacious in preventing acute SIVmne infection.

Published
1994

2. Characterization of a molecular clone of HIV type 2 infectious for Macaca nemestrina

Author

William R. Morton, Günter Kraus, David Looney, Flossie Wong-Staal, Patricia Badel, Randy Talbott, Curtis Bartz, Mark C. Leavitt, A. Radaelli, and Ann Schmidt

Subjects
viruses, Immunology, Molecular Sequence Data, Clone (cell biology), Viremia, HIV Infections, Virus, Virology, medicine, Animals, Humans, Amino Acid Sequence, Phylogeny, biology, Base Sequence, Sequence Homology, Amino Acid, Macaca nemestrina, virus diseases, Transfection, Provirus, medicine.disease, biology.organism_classification, Disease Models, Animal, Infectious Diseases, Phenotype, Cell culture, Lentivirus, HIV-2, Sequence Alignment
Abstract

A lambda phage clone containing a full-length HIV-2 provirus, designated HIV-2KR, was obtained from the genomic DNA of Molt4 clone 8 (Molt4/8) lymphoblastic cells infected with the HIV-2PEI2 strain. HIV-2KR is genetically distinct from known HIV-2 isolates, possessing both a unique deletion in the LTR promoter region, and a long rev reading frame. It is replication competent in vitro after transfection into Molt4/8 cells, replicates in a variety of established human T lymphoblastic (Molt-3, Molt4/8, SupT1, H9, C8166) and myelomonocytic (U937) cell lines, and displays prominent cytopathic effects on infection of Molt4/8 cells, reflecting usage of both CCR5 and CXCR4 coreceptors. In addition, HIV-2KR was found to be infectious for human and Macaca nemestrina peripheral blood lymphocytes, and primary human monocyte-macrophage cultures. Intravenous inoculation of cell-free virus into M. nemestrina resulted in infection characterized by transient, low-level viremia and modest temporary decline in CD4 lymphocyte numbers, making HIV-2KR the first HIV-2 molecular clone reported to be infectious for this primate species.

Published
1998

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