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204 results on '"Cusimano G."'

1. T.07.7: CHARACTERISTICS AND MANAGEMENT OF HEPATOCELLULAR CARCINOMA (HCC) IN SICILY: FIRST RESULTS OF THE HCC SICILY MULTIDISCIPLINARY NETWORK

Author

Celsa, C., primary, Cabibbo, G., additional, Ciccia, R., additional, Di Maria, G., additional, Pagano, D., additional, Miraglia, R., additional, Maruzzelli, L., additional, Bavetta, M.G., additional, Barcellona, M.R., additional, Cocuzza, C., additional, Tavarelli, M., additional, Filomia, R., additional, Pitrone, C., additional, Malizia, G., additional, Bertino, G., additional, Salomone, F., additional, Distefano, M., additional, Mitra, M., additional, Cartabellotta, F., additional, Giannitrapani, L., additional, Giuffrida, D., additional, Spada, M., additional, Alaimo, G., additional, Sambataro, D., additional, Sportato, G., additional, Grassini, M.V., additional, Cannella, R., additional, Antonucci, M., additional, D'Amato, F., additional, Capodicasa, L., additional, Grova, A., additional, Rao, S., additional, Salvato, M., additional, Cusimano, G., additional, Gaudioso, V., additional, Sparacino, A., additional, Mercurio, F., additional, Rizzo, G.E.M., additional, Picciotto, V., additional, Montenegro, R., additional, Arena, S., additional, Saitta, C., additional, Russello, M., additional, Fusco, G., additional, Di Marco, V., additional, Gruttadauria, S., additional, and Cammà, C., additional

Published
2024
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2. Sviluppo rurale in Italia, una ricognizione sulle prospettive della prossima pianificazione

Author

Cusimano, G, Mercatanti, L, Messina, G, Rocca, L, Castiglioni, B, Lo Presti, L, Cusimano, G, Mercatanti, L, and Messina, G

Subjects
Piano Strategico Nazionale, Politica Agricola Comune, Partenariato, Settore M-GGR/02 - Geografia Economico-Politica
Abstract

This paper intends to represent a preliminary recognition of the programmatic synergies that aim to harmonize, in a cross-scale perspective, the general objectives of the Common Agricultural Policy - CAP - with national and local intervention policies.

Published
2023

3. Characteristics and management of hepatocellular carcinoma (HCC) in Sicily: first results of the HCC Sicily Multidisciplinary Network

Author

Celsa, C., Cabibbo, G., Ciccia, R., Di Maria, G., Pagano, D., Miraglia, R., Maruzzelli, L., Bavetta, M.G., Barcellona, M.R., Cocuzza, C., Tavarelli, M., F, R., Pitrone, C., Malizia, G., Bertino, G., Salomone, F., Distefano, M., Mitra, M., Cartabellotta, F., Giannitrapani, L., Giuffrida, D., Spada, M., Alaimo, G., Sambataro, D., Sportato, G., Grassini, M.V., Cannella, R., Antonucci, M., D'Amato, F., Capodicasa, L., Grova, A., Rao, S., Salvato, M., Cusimano, G., Gaudioso, V., Sparacino, A., Mercurio, F., Rizzo, M., Picciotto, V., Montenegro, R., Arena, S., Saitta, C., Russello, M., Fusco, G., Di Marco, V., Gruttadauria, S., and Cammà, C.

Published
2024
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4. La Chinatown palermitana: forme di comunità e commercio

Author

Cusimano G, Giannone M, Cusimano, G, Cusimano G, and Giannone M

Subjects
Settore M-GGR/02 - Geografia Economico-Politica, Commercio, Sicilia, sviluppo, Settore M-GGR/01 - Geografia
Abstract

A Palermo, a partire dagli anni Ottanta, via Lincoln cominciò a conoscere un inaspettato flusso migratorio di cinesi. Il luogo di origine dei cittadini cinesi trasferitisi a Palermo in quegli anni in realtà era lo stesso dei migranti cinesi che già a partire dai primi decenni del secolo scorso avevano cominciato a popolare alcune città italiane del Centro-Nord, in quel caso trovando occupazione soprattutto come commercianti ambulanti o lavoratori marittimi. Il contributo, attraverso l'analisi sul campo e la somministrazione di questionari, indaga l'evoluzione commerciale della via Lincoln.

Published
2019

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Author

Contardi, M, Alfaro-Pulido, A, Picone, P, Guzman-Puyol, S, Goldoni, L, Benitez, J, Heredia, A, Barthel, M, Ceseracciu, L, Cusimano, G, Brancato, O, Di Carlo, M, Athanassiou, A, Heredia-Guerrero, J, Contardi M., Alfaro-Pulido A., Picone P., Guzman-Puyol S., Goldoni L., Benitez J. J., Heredia A., Barthel M. J., Ceseracciu L., Cusimano G., Brancato O. R., Di Carlo M., Athanassiou A., Heredia-Guerrero J. A., Contardi, M, Alfaro-Pulido, A, Picone, P, Guzman-Puyol, S, Goldoni, L, Benitez, J, Heredia, A, Barthel, M, Ceseracciu, L, Cusimano, G, Brancato, O, Di Carlo, M, Athanassiou, A, Heredia-Guerrero, J, Contardi M., Alfaro-Pulido A., Picone P., Guzman-Puyol S., Goldoni L., Benitez J. J., Heredia A., Barthel M. J., Ceseracciu L., Cusimano G., Brancato O. R., Di Carlo M., Athanassiou A., and Heredia-Guerrero J. A.

Published
2019

7. Combining dietary phenolic antioxidants with polyvinylpyrrolidone: Transparent biopolymer films based on: P-coumaric acid for controlled release

Author

Contardi, M, Heredia-Guerrero, J, Guzman-Puyol, S, Summa, M, Benitez, J, Goldoni, L, Caputo, G, Cusimano, G, Picone, P, Di Carlo, M, Bertorelli, R, Athanassiou, A, Bayer, I, Contardi M., Heredia-Guerrero J. A., Guzman-Puyol S., Summa M., Benitez J. J., Goldoni L., Caputo G., Cusimano G., Picone P., Di Carlo M., Bertorelli R., Athanassiou A., Bayer I. S., Contardi, M, Heredia-Guerrero, J, Guzman-Puyol, S, Summa, M, Benitez, J, Goldoni, L, Caputo, G, Cusimano, G, Picone, P, Di Carlo, M, Bertorelli, R, Athanassiou, A, Bayer, I, Contardi M., Heredia-Guerrero J. A., Guzman-Puyol S., Summa M., Benitez J. J., Goldoni L., Caputo G., Cusimano G., Picone P., Di Carlo M., Bertorelli R., Athanassiou A., and Bayer I. S.

Abstract

Polyvinylpyrrolidone (PVP) has probably been one of the most utilized pharmaceutical polymers with applications ranging from a blood plasma substitute to nanoparticle drug delivery, since its synthesis in 1939. It is a highly biocompatible, non-toxic and transparent film forming polymer. Although high solubility of PVP in aqueous environment is advantageous, it still poses several problems for some applications in which sustained targeting and release are needed or hydrophobic drug inclusion and delivery systems are to be designed. In this study, we demonstrate that a common dietary phenolic antioxidant, p-coumaric acid (PCA), can be combined with PVP covering a wide range of molar ratios by solution blending in ethanol, forming new transparent biomaterial films with antiseptic and antioxidant properties. PCA not only acts as an effective natural plasticizer but also establishes H-bonds with PVP increasing its resistance to water dissolution. PCA could be released in a sustained manner up to a period of 3 days depending on the PVP/PCA molar ratio. Sustained drug delivery potential of the films was studied using methylene blue and carminic acid as model drugs, indicating that the release can be controlled. Antioxidant and remodeling properties of the films were evaluated in vitro by free radical cation scavenging assay and in vivo on a murine model, respectively. Furthermore, the material resorption of films was slower as PCA concentration increased, as observed from the in vivo full-thickness excision model. Finally, the antibacterial activity of the films against common pathogens such as Escherichia coli and Staphylococcus aureus and the effective reduction of inflammatory agents such as matrix metallopeptidases were demonstrated. All these properties suggest that these new transparent PVP/PCA films can find a plethora of applications in pharmaceutical sciences including skin and wound care.

Published
2019

10. Geografia e immaginazione

Author

Mercatanti L, cusimano g, sabato G, and Mercatanti L, cusimano g, sabato G

Subjects
Geografia, Strabone, Carl Sauer, turismo creativo, Settore M-GGR/01 - Geografia
Abstract

Per lungo tempo la Geografia è stata intesa come disciplina descrittiva. La stessa etimologia, ad una prima analisi, non lascia spazio ad alcun elemento legato all’immaginazione. In questo lavoro sono proposti alcuni esempi del ruolo dell’immaginazione nei vari campi e nell’uso degli strumenti della disciplina geografica.

Published
2018

12. An integrated proteomic and bioinformatic approach for identification of Alzheimer's disease early biomarkers

Author

Nuzzo D, Cusimano G, Inguglia L( Picone P, Galizzi G, Brancato OR, Cristaldi L, Caruana L, and Di Carlo M

Subjects
proteomica, Bioinformatica, Alzheimer's disease
Abstract

Motivation: An increase in human life span is expected to double in the next 30 years. As the elderly population expands, the prevalence of neurodegenerative diseases such as Alzheimer's disease (AD) or other forms of dementia is likely increasing, inducing consequently profound economic and social implications. Thirty-five million people are now considered to be affected by AD and this number is expected to double in the next few decades. Consequently, AD is now considered a very serious public health problem mainly for the direct and indirect costs of their care. One of the histopathological hallmarks of AD is the amyloid plaques formation in the brain. The plaques are mainly constituted by aggregates of A? peptide, a peptide generated by a proteolytic cleavage of the amyloid precursor protein (APP). However, the early events in the onset of the pathology are yet to be fully explained and the mechanisms through which A? triggers the cascade of events leading to AD are unknown. Alterations in proteomic pathway have been described in many neurodegenerative diseases, including in AD. The aim of this study was identified potential biomarkers involved in early AD stage by using proteomic approach and bioinformatic tools. For this purpose, we experimentally mimed AD early stage conditions by using neuronal cells treated for short time with A? peptide. Methods: LAN5 neuroblastoma cells were incubated without (control) or with A? peptide for a short time (1 hour) at 37°C. Proteins obtained from these cells were analyzed with a shotgun proteomics approach by LTQ-Orbitrap-MS followed by label-free quantitation. Significantly up- and down-regulated proteins were identified by volcano plot STRING was used to visualize protein-protein interaction between the proteins identified as modulated. DAVID and REViGO were used for GO annotation. LAN5 protein expression after A? treatment was analyzed by Western blot incubated with specific antibodies. Results: An in vitro AD early stage was simulate by treating LAN5 cells with A? for short time. Protein extracted from untreated and treated cells were subjected to shotgun proteomic analysis followed by bioinformatics approach. A volcano plot was built from the mass spectrometry data for visualizing significantly modulated proteins (p < 0. 05 and log2- fold change 0.5). A total of 159 proteins were found to be up-regulated and 88 to be down-regulated relative to the control. By STRING and GO annotation two protein-protein interaction networks were identified. The first network contained proteins related to rRNA metabolism and the second one consisted mainly of proteins related to RNA metabolism, and many with the splicing process. The pathway enrichment identified using KEGG mainly showed up-regulation of the lysosomal pathway and down regulation of the spliceosomal pathway. To confirm that A? inhibits expression of proteins involved in the spliceosomal pathway the modulation of expression of SmB /B'/N and PRP6, two ubiquitous proteins of the spliceosome, was analyzed. By Western blot incubated with specific antibodies we confirmed down regulation of these proteins in a time-dependent manner. In conclusion, this study provides evidence that a short exposure of LAN5 with A? can be considered a model to mimic early AD stages. Several up- and down-regulated proteins involved in different dysfunction occurring in AD have been found as a consequence of A? stimulation. In particular, down-regulation of spliceosome components suggests that the modification of the splicing machinery is a key event in early AD and the proteins involved can be utilized as potential biomarkers.

Published
2019

14. Gerarchie territoriali e commercio in Sicilia

Author

Cusimano G., Barilaro C., CANNIZZARO, SALVATORE, CIRELLI, CATERINA, Mercatanti L., PORTO, Carmelo Maria, PRIVITERA, DONATELLA, Sabato G, Viganoni L, and Cusimano G., Barilaro C., Cannizzaro S., Cirelli C., Mercatanti L., Porto CM, Privitera D, Sabato G

Subjects
Settore M-GGR/02 - Geografia Economico-Politica, Commercio, Sicilia, sviluppo, Settore M-GGR/01 - Geografia
Abstract

Il paper sintetizza le fasi della ricerca dell'Unità Locale siciliana nell'ambito del PRIN 2015 "Commercio, consumo e città. Pratiche, pianificazione e governance per l’inclusione, la resilienza e la sostenibilità urbane" coordinato da Lida Viganoni (UNiversità degli Studi di Napoli 'L'Orientale'".

Published
2017

15. Combining dietary phenolic antioxidants with polyvinylpyrrolidone: Transparent biopolymer films based on: P-coumaric acid for controlled release

Author

Contardi, M., Heredia-Guerrero, José A., Guzmán-Puyol, Susana, Summa, M., Benítez, José J., Goldoni, Luca, Caputo, G., Cusimano, G., Picone, P., Di Carlo, Marta, Bertorelli, Roberto, Athanassiou, Athanassia, Bayer, lker S., Contardi, M., Heredia-Guerrero, José A., Guzmán-Puyol, Susana, Summa, M., Benítez, José J., Goldoni, Luca, Caputo, G., Cusimano, G., Picone, P., Di Carlo, Marta, Bertorelli, Roberto, Athanassiou, Athanassia, and Bayer, lker S.

Abstract

Polyvinylpyrrolidone (PVP) has probably been one of the most utilized pharmaceutical polymers with applications ranging from a blood plasma substitute to nanoparticle drug delivery, since its synthesis in 1939. It is a highly biocompatible, non-toxic and transparent film forming polymer. Although high solubility of PVP in aqueous environment is advantageous, it still poses several problems for some applications in which sustained targeting and release are needed or hydrophobic drug inclusion and delivery systems are to be designed. In this study, we demonstrate that a common dietary phenolic antioxidant, p-coumaric acid (PCA), can be combined with PVP covering a wide range of molar ratios by solution blending in ethanol, forming new transparent biomaterial films with antiseptic and antioxidant properties. PCA not only acts as an effective natural plasticizer but also establishes H-bonds with PVP increasing its resistance to water dissolution. PCA could be released in a sustained manner up to a period of 3 days depending on the PVP/PCA molar ratio. Sustained drug delivery potential of the films was studied using methylene blue and carminic acid as model drugs, indicating that the release can be controlled. Antioxidant and remodeling properties of the films were evaluated in vitro by free radical cation scavenging assay and in vivo on a murine model, respectively. Furthermore, the material resorption of films was slower as PCA concentration increased, as observed from the in vivo full-thickness excision model. Finally, the antibacterial activity of the films against common pathogens such as Escherichia coli and Staphylococcus aureus and the effective reduction of inflammatory agents such as matrix metallopeptidases were demonstrated. All these properties suggest that these new transparent PVP/PCA films can find a plethora of applications in pharmaceutical sciences including skin and wound care.

Published
2019

18. Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post‐Hoc Analysis of the GISSI‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) Trial

Author

Dauriz, Marco, primary, Targher, Giovanni, additional, Temporelli, Pier Luigi, additional, Lucci, Donata, additional, Gonzini, Lucio, additional, Nicolosi, Gian Luigi, additional, Marchioli, Roberto, additional, Tognoni, Gianni, additional, Latini, Roberto, additional, Cosmi, Franco, additional, Tavazzi, Luigi, additional, Maggioni, Aldo Pietro, additional, Barlera, Simona, additional, Franzosi, Maria Grazia, additional, Maggioni, Aldo P., additional, Porcu, Maurizio, additional, Yusuf, Salim, additional, Camerini, Fulvio, additional, Cohn, Jay N., additional, Decarli, Adriano, additional, Pitt, Bertram, additional, Sleight, Peter, additional, Poole‐Wilson, Philip A., additional, Geraci, Enrico, additional, Scherillo, Marino, additional, Fabbri, Gianna, additional, Bartolomei, Barbara, additional, Bertoli, Daniele, additional, Cobelli, Franco, additional, Fresco, Claudio, additional, Ledda, Antonietta, additional, Levantesi, Giacomo, additional, Opasich, Cristina, additional, Rusconi, Franco, additional, Sinagra, Gianfranco, additional, Turazza, Fabio, additional, Volpi, Alberto, additional, Ceseri, Martina, additional, Alongi, Gianluca, additional, Atzori, Antonio, additional, Bambi, Filippo, additional, Bastarolo, Desiree, additional, Bianchini, Francesca, additional, Cangioli, Iacopo, additional, Canu, Vittoriana, additional, Caporusso, Concetta, additional, Cenni, Gabriele, additional, Cintelli, Laura, additional, Cocchio, Michele, additional, Confente, Alessia, additional, Fenicia, Eva, additional, Friso, Giorgio, additional, Gianfriddo, Marco, additional, Grilli, Gianluca, additional, Lazzaro, Beatrice, additional, Lonardo, Giuseppe, additional, Luise, Alessia, additional, Nota, Rachele, additional, Orlando, Mariaelena, additional, Petrolo, Rosaria, additional, Pierattini, Chiara, additional, Pierota, Valeria, additional, Provenzani, Alessandro, additional, Quartuccio, Velia, additional, Ragno, Anna, additional, Serio, Chiara, additional, Spolaor, Alvise, additional, Tafi, Arianna, additional, Tellaroli, Elisa, additional, Ghio, Stefano, additional, Ghizzardi, Elisa, additional, Masson, Serge, additional, Crociati, Lella, additional, La Rovere, Maria Teresa, additional, Corrà, Ugo, additional, Finzi, Andrea, additional, Gorini, Marco, additional, Milani, Valentina, additional, Orsini, Giampietro, additional, Bianchini, Elisa, additional, Cabiddu, Silvia, additional, Cangioli, Ilaria, additional, Cipressa, Laura, additional, Cipressa, Maria Lucia, additional, Di Bitetto, Giuseppina, additional, Ferri, Barbara, additional, Galbiati, Luisa, additional, Lorimer, Andrea, additional, Pera, Carla, additional, Priami, Paola, additional, Vasamì, Antonella, additional, Moccetti, T., additional, Rossi, M.G., additional, Pasotti, E., additional, Vaghi, F., additional, Roncarolo, P., additional, Zunino, M.T., additional, Matta, F., additional, Perinetto, E. Actis, additional, Gaita, F., additional, Azzaro, G., additional, Zanetta, M., additional, Paino, A.M., additional, Parravicini, U., additional, Vegis, D., additional, Conte, R., additional, Ferraro, P., additional, De Bernardi, A., additional, Morelloni, S., additional, Fagnani, M., additional, Lucchina, P. Greco, additional, Montagna, L., additional, Bellone, E., additional, Sappè, D., additional, Ferraro, F., additional, Delucchi, M., additional, Reynaud, S.G., additional, Dore, M., additional, La Brocca, A., additional, Massobrio, N., additional, Bo, L., additional, Trinchero, R., additional, Imazio, M., additional, Brocchi, G., additional, Nejrotti, A., additional, Rissone, L., additional, Gabasio, S., additional, Zocchi, C., additional, Randazzo, S., additional, Crenna, A., additional, Giannuzzi, P., additional, Bonanomi, E., additional, Mezzani, A., additional, De Marchi, M., additional, Begliuomini, G., additional, Gianonatti, C.A., additional, Gavazzi, A., additional, Grosu, A., additional, Dei Cas, L., additional, Nodari, S., additional, Garyfallidis, P., additional, Bertoletti, A., additional, Bonifazi, C., additional, Arisi, S., additional, Mascaro, F., additional, Fraccarollo, M., additional, Dell'Orto, S., additional, Sfolcini, M., additional, Bortolini, F., additional, Raccagni, D., additional, Turelli, A., additional, Santarone, M., additional, Miglierina, E., additional, Sormani, L., additional, Jemoli, R., additional, Tettamanti, F., additional, Pirelli, S., additional, Bianchi, C., additional, Verde, S., additional, Mariani, M., additional, Ziacchi, V., additional, Ferrazza, A., additional, Russo, A., additional, Bortolotti, M., additional, Pasini, G.F., additional, Volpi, A., additional, Jones, K.N., additional, Cuzzucrea, D., additional, Gullace, G., additional, Carbone, C., additional, Granata, A., additional, De Servi, S., additional, Del Rosso, G., additional, Inserra, C., additional, Renaldini, E., additional, Zappa, C., additional, Moretti, M., additional, Zanini, R., additional, Ferrari, M., additional, Moroni, E., additional, Cei, A., additional, Lissi, C., additional, Dovico, E., additional, Fiorentini, C., additional, Palermo, P., additional, Brusoni, B., additional, Negrini, M., additional, Heyman, J., additional, Danzi, G.B., additional, Finzi, A., additional, Frigerio, M., additional, Turazza, F., additional, Beretta, L., additional, Sachero, A., additional, Casazza, F., additional, Squadroni, L., additional, Lombardi, F., additional, Marano, L., additional, Margonato, A., additional, Fragasso, G., additional, Febo, O.C., additional, Aiolfi, E., additional, Olmetti, F., additional, Grieco, A., additional, Antonazzo, V., additional, Specchia, G., additional, Mortara, A., additional, Robustelli, F., additional, Songini, M.G., additional, Schweiger, C., additional, Frisinghelli, A., additional, Palvarini, M., additional, Campana, C., additional, Scelsi, L., additional, Ajmone Marsan, N., additional, Cobelli, F., additional, Gualco, A., additional, Opasich, C., additional, De Feo, S., additional, Mazzucco, R., additional, Iannone, M.A., additional, Diaco, T., additional, Zaniboni, D., additional, Milanesi, G., additional, Nassiacos, D., additional, Meloni, S., additional, Giani, P., additional, Nicoli, T., additional, Malinverni, C., additional, Gusmini, A., additional, Pozzoni, L., additional, Bisiani, G., additional, Margaroli, P., additional, Schizzarotto, A., additional, Daverio, A., additional, Occhi, G., additional, Partesana, N., additional, Bandini, P., additional, Rosella, M.G., additional, Giustiniani, S., additional, Cucchi, G., additional, Pedretti, R., additional, Raimondo, R., additional, Vaninetti, R., additional, Fedele, A., additional, Ghezzi, I., additional, Rezzonico, E., additional, Salerno Uriarte, J.A., additional, Morandi, F., additional, Salvucci, F., additional, Valenti, C., additional, Graziano, G., additional, Romanò, M., additional, Cimminiello, C., additional, Mangone, I., additional, Lombardo, M., additional, Quorso, P., additional, Marinoni, G., additional, Breghi, M., additional, Erckert, M., additional, Dienstl, A., additional, Mirante Marini, G., additional, Stefenelli, C., additional, Cioffi, G., additional, Buczkowska, E., additional, Bonanome, A., additional, Bazzanini, F., additional, Parissenti, L., additional, Serafini, C., additional, Catania, G., additional, Tarantini, L., additional, Rigatelli, G., additional, Boni, S., additional, Pasini, A., additional, Masini, E., additional, Zampiero, A.A., additional, Zanchetta, M., additional, Franceschetto, L., additional, Delise, P., additional, Marcon, C., additional, Sacchetta, A., additional, Borgese, L., additional, Artusi, L., additional, Casolino, P., additional, Corbara, F., additional, Banzato, A., additional, Barbiero, M., additional, Aldegheri, M.P., additional, Bazzucco, R., additional, Crivellenti, G., additional, Raviele, A., additional, Zanella, C., additional, Pascotto, P., additional, Sarto, P., additional, Milan, S., additional, Barbieri, E., additional, Girardi, P., additional, Dalla Villa, W., additional, Dalle Mule, J., additional, Di Sipio, M.L., additional, Cazzin, R., additional, Milan, D., additional, Zonzin, P., additional, Carraro, M., additional, Rossi, R., additional, Carbonieri, E., additional, Rossi, I., additional, Stritoni, P., additional, Meneghetti, P., additional, Risica, G., additional, Tenderini, P.L., additional, Vassanelli, C., additional, Zanolla, L., additional, Perini, G., additional, Brighetti, G., additional, Chiozza, R., additional, Giuliano, G., additional, Gortan, R., additional, Cesanelli, R., additional, Nicolosi, G.L., additional, Piazza, R., additional, Mos, L., additional, Vriz, O., additional, Pavan, D., additional, Pascottini, G., additional, Alberti, E., additional, Werren, M., additional, Solinas, L., additional, Sinagra, G., additional, Longaro, F., additional, Fioretti, P., additional, Albanese, M.C., additional, Miani, D., additional, Gianrossi, R., additional, Pende, A., additional, Rubartelli, P., additional, Magaia, O., additional, Domenicucci, S., additional, Caruso, D., additional, Faraguti, A.S., additional, Magliani, L., additional, Miccoli, F., additional, Guglielmino, G., additional, Bertoli, D., additional, Cantarelli, A., additional, Orlandi, S., additional, Vallebona, A., additional, Pozzati, A., additional, Brega, G., additional, Pancaldi, L.G., additional, Vandelli, R., additional, Urbinati, S., additional, Poci, M.G., additional, Zoli, M., additional, Costa, G.M., additional, Guiducci, U., additional, Zobbi, G., additional, Tartagni, F., additional, Tisselli, A., additional, Gentili, A., additional, Pieri, P., additional, Cagnetta, E., additional, Bendinelli, S., additional, Barbieri, A., additional, Conti, R., additional, Ferrari, R., additional, Merlini, F., additional, Fucili, A., additional, Moruzzi, P., additional, Buia, E., additional, Galvani, M., additional, Ferrini, D., additional, Baggioni, G., additional, Yiannacopulu, P., additional, Canè, G., additional, Bonfiglioli, A., additional, Zandomeneghi, R., additional, Brugioni, L., additional, Giannini, A., additional, Di Ruvo, R., additional, Giuliani, M., additional, Rusconi, L., additional, Del Corso, P., additional, Piovaccari, G., additional, Bologna, F., additional, Venturi, P., additional, Melandri, F., additional, Bagni, E., additional, Bolognese, L., additional, Perticucci, R., additional, Zuppiroli, A., additional, Nannini, M., additional, Consoli, N., additional, Petrone, P., additional, Pipitò, C., additional, Colombi, L., additional, Bernardi, D., additional, Mariani, P.R., additional, Testa, R., additional, Mazzinghi, F., additional, Cosmi, F., additional, Cosmi, D., additional, Zipoli, A., additional, Cecchi, A., additional, Castelli, G., additional, Ciaccheri, M., additional, Mori, F., additional, Pieri, F., additional, Valoti, P., additional, Chiarantini, D., additional, Santoro, G.M., additional, Minneci, C., additional, Marchi, F., additional, Milli, M., additional, Zambaldi, G., additional, Brandinelli Geri, A.A., additional, Cipriani, M., additional, Alessandri, M., additional, Severi, S., additional, Stefanelli, S., additional, Comella, A., additional, Poddighe, R., additional, Digiorgio, A., additional, Carluccio, M., additional, Berti, S., additional, Rizza, A., additional, Bonatti, V., additional, Molendi, V., additional, Brancato, A., additional, D'Aprile, N., additional, Giappichini, G., additional, Del Vecchio, S., additional, Mantini, G., additional, De Tommasi, F., additional, Meucci, G., additional, Cordoni, M., additional, Bechi, S., additional, Barsotti, L., additional, Baldini, P., additional, Romei, M., additional, Scopelliti, G., additional, Lauri, G., additional, Pestelli, F., additional, Furiozzi, F., additional, Cocchieri, M., additional, Severini, D., additional, Patriarchi, F., additional, Chiocchi, P., additional, Buccolieri, M., additional, Martinelli, S., additional, Wee, A., additional, Angelici, F., additional, Bernardinangeli, M., additional, Proietti, G., additional, Biscottini, B., additional, Panciarola, R., additional, Marinacci, L., additional, Perna, G.P., additional, Gabrielli, D., additional, Moraca, A., 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Podda, A., additional, Ledda, M., additional, Siddi, P., additional, Lai, C., additional, Pili, G., additional, Mercuro, G., additional, Mureddu, G., additional, Ganau, A., additional, Meloni, G., additional, Poddighe, G., additional, and Sanna, G., additional

Published
2017
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19. Cultural Creativity and Local Development: The Experience of the Socio-Cultural District of Selinunte

Author

Cusimano, G, Giannone., M, Morvillo, A., Cusimano, G, and Giannone., M

Subjects
Selinunte, development, Settore M-GGR/01 - Geografia
Abstract

The pivotal idea of the Socio-Cultural District of Selinunte was inspired by a concept we found as a gift in that inexhaustible source of ideas that Borges’ texts (1995) still are. It might seem absurd to think of the biography of Michelangelo without any of his works… Yet, if we carefully think about it, we will realise that the endless series of acts composing the mosaic of a whole life is wide enough to allow us connecting a limited number of events among them. In addition, if we put those events in a diachronic sequence, they will take on the characteristics of a biography! That is Borges, up to here. If we select a different subject though, a territory for example, a consistent physiognomy could emerge in this case too, even if we leave aside the Temple ‘C’ of Selinunte or even the whole monument area of one of the largest and most complex archaeological parks in the Mediterranean area. We live in an era of cultures and territories, with emerging subjects who want to gain the place and role in history that have been long denied to them. This is also an era of decline of absolute values and grand theories. All that given, regaining (rebuilding or even making up) one’s identity is an inescapable strategic shift. Who will be in charge with the task of outlining the borders and contents of a community space? Who will be held responsible for drawing a face that is marked by the passing of time and made lively by our fresh contemporary energies? How can we avoid heritage becoming a burden rather than a challenge to think about the future?

Published
2012

21. Regular Wine Consumption in Chronic Heart Failure: Impact on Outcomes, Quality of Life, and Circulating Biomarkers

Author

Cosmi, Franco, Di Giulio, Paola, Masson, Serge, Finzi, Andrea, Marfisi, Rosa Maria, Cosmi, Deborah, Scarano, Marco, Tognoni, Gianni, Maggioni, Aldo P., Porcu, Maurizio, Boni, Silvana, Cutrupi, Giovanni, Tavazzi, Luigi, Latini, Roberto Tavazzi, L, Tognoni, G, Barlera, S, Franzosi, Mg, Latini, R, Lucci, D, Maggioni, Ap, Marchioli, R, Nicolosi, Gl, Porcu, M, Yusuf, S, Camerini, F, Cohn, Jn, Decarli, A, Pitt, B, Sleight, P, Poole-Wilson, Pa, Geraci, E, Scherillo, M, Fabbri, G, Bartolomei, B, Bertoli, D, Cobelli, F, Fresco, C, Ledda, A, Levantesi, G, Opasich, C, Rusconi, F, Sinagra, G, Turazza, F, Volpi, A, Ceseri, M, Alongi, G, Atzori, A, Bambi, F, Bastarolo, D, Bianchini, F, Cangioli, I, Canu, V, Caporusso, C, Cenni, G, Cintelli, L, Cocchio, M, Confente, A, Fenicia, E, Friso, G, Gianfriddo, M, Grilli, G, Lazzaro, B, Lonardo, G, Luise, A, Nota, R, Orlando, M, Petrolo, R, Pierattini, C, Pierota, V, Provenzani, A, Quartuccio, V, Ragno, A, Serio, C, Spolaor, A, Tafi, A, Tellaroli, E, Ghio, S, Ghizzardi, E, Masson, S, Crociati, L, Rovere, Mt, Corra, U, Di Giulio, P, Finzi, A, Gorini, M, Gonzini, L, Milani, V, Orsini, G, Bianchini, E, Cabiddu, S, Cipressa, L, Cipressa, Ml, Di Bitetto, G, Ferri, B, Galbiati, L, Lorimer, A, Pera, C, Priami, P, Rossi, Mg, Pasotti, E, Vaghi, F, Roncarolo, P, Zunino, Mt, Matta, F, Actis, E, Gaita, F, Azzaro, G, Zanetta, M, Paino, Am, Parravicini, U, Vegis, D, Conte, R, Ferraro, P, De Bernardi, A, Morelloni, S, Fagnani, M, Lucchina, Pg, Montagna, L, Bellone, E, Sappe, D, Ferraro, F, Delucchi, M, Reynaud, Sg, Dore, M, La, A, Massobrio, N, Bo, L, Trinchero, R, Imazio, M, Brocchi, G, Nejrotti, A, Rissone, L, Gabasio, S, Zocchi, C, Randazzo, S, Crenna, A, Giannuzzi, P, Bonanomi, E, Mezzani, A, De Marchi, M, Begliuomini, G, Gianonatti, Ca, Gavazzi, A, Grosu, A, Cas, Ld, Nodari, S, Garyfallidis, P, Bertoletti, A, Bonifazi, C, Arisi, S, Mascaro, F, Fraccarollo, M, Dell, S, Sfolcini, M, Bortolini, F, Raccagni, D, Turelli, A, Santarone, M, Miglierina, E, Sormani, L, Jemoli, R, Tettamanti, F, Pirelli, S, Bianchi, C, Verde, S, Mariani, M, Ziacchi, V, Ferrazza, A, Russo, A, Bortolotti, M, Pasini, Gf, Jones, Kn, Cuzzucrea, D, Gullace, G, Carbone, C, Granata, A, De, S, Del Rosso, G, Inserra, C, Renaldini, E, Zappa, C, Moretti, M, Zanini, R, Ferrari, M, Cei, A, Lissi, C, Dovico, E, Fiorentini, C, Palermo, P, Brusoni, B, Negrini, M, Heyman, J, Danzi, Gb, Frigerio, M, Beretta, L, Sachero, A, Casazza, F, Squadroni, L, Lombardi, F, Marano, L, Margonato, A, Fragasso, G, Febo, Oc, Aiolfi, E, Olmetti, F, Grieco, A, Antonazzo, V, Specchia, G, Mortara, A, Robustelli, F, Songini, Mg, Schweiger, C, Frisinghelli, A, Palvarini, M, Campana, C, Scelsi, L, Marsan, Na, Gualco, A, De Feo, S, Iannone, Ma, Diaco, T, Zaniboni, D, Milanesi, G, Nassiacos, D, Meloni, S, Giani, P, Nicoli, T, Malinverni, C, Gusmini, A, Pozzoni, L, Bisiani, G, Margaroli, P, Schizzarotto, A, Daverio, A, Morelli, E, Occhi, G, Partesana, N, Bandini, P, Rosella, Mg, Giustiniani, S, 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Caro, G, Di Nola, R, Piemonte, F, Prinzi, D, De Rosa, P, De, V, Riello, F, Capuano, V, Vecchio, G, Landi, M, Amato, S, Garofalo, M, D'Avino, M, Sensale, P, Maiolica, O, Santoro, R, Caso, P, Miceli, D, Maurea, N, Bianchi, U, Crispo, C, Chiariello, M, Filardi, Pp, Russo, L, Capuano, N, Ungaro, G, Vergara, G, Scafuro, F, D'Angelo, G, Campaniello, C, Bottiglieri, P, Volpe, A, Battista, R, De Risi, L, Cardillo, G, Sibilio, G, Marino, Ap, Silvestri, F, Predotti, P, Iervoglini, A, De Matteis, C, Sarnicola, P, Matarazzo, Mm, Baldi, S, Iuliano, V, Astarita, C, Cuccaro, P, Liguori, A, Liguori, G, Gregorio, G, Petraglia, L, Antonelli, G, Amodio, G, De Luca, I, Franchini, G, Lenti, Ml, Cavallari, D, D'Agostino, C, Scalera, G, Altamura, Cm, Russo, M, Mascolo, Ar, Pettinati, G, Ciricugno, Sa, Scrutinio, D, Passantino, A, Mastrangelo, D, Di Masi, A, De, R, Cannone, M, Dibiase, F, Pensato, M, Loliva, F, Trapani, F, Panettieri, I, Leone, L, Di, M, Carrone, M, Gallone, V, Cocco, F, Costantini, M, Tritto, C, Cavalieri, F, Stella, L, Magliari, F, Callerame, M, De Giorgi, A, Pellegrino, L, Correra, M, Portulano, V, Nisi, Gl, Grassi, G, Cristallo, E, De Laura, D, Salerno, C, Fanelli, R, Villella, M, Pede, S, Renna, A, De Lorenzi, E, Urso, L, Lenti, V, Peluso, A, Baldi, N, Polimeni, G, Palma, P, Lauletta, R, Tagliamonte, E, Cirillo, T, Centonze, G, D'Alessandro, B, Truncellito, L, Mecca, D, Petruzzi, Ma, Coviello, Ro, Lopizzo, A, Chiaffitelli, M, Barbuzzi, S, Gubelli, S, Germinario, G, Cosentino, N, Mingrone, A, Vico, R, Borrello, G, Mazza, Ml, Cimino, R, Galasso, D, Cassadonte, F, Talarico, U, Perticone, F, Cassano, S, Catapano, F, Calemme, S, Feraco, E, Cloro, C, Misuraca, G, Caporale, R, Vigna, L, Spagnuolo, V, De Rosa, F, Spadafora, G, Zampaglione, G, Russo, R, Schipani, Fa, Ferragina, Af, Stranieri, D, Musca, G, Carpino, C, Bencardino, P, Raimondo, F, Musacchio, D, Pulitano, G, Ruggeri, A, Provenzano, A, Salituri, S, Musolino, M, Calandruccio, S, Marrari, A, Tripodi, E, Scali, R, Anastasio, L, Arone, A, Aragona, P, Donnangelo, L, Comito, Mg, Bilotta, F, Vaccaro, I, Rametta, R, Ventura, V, Bonvegna, A, Alì, A, Cinnirella, C, Raineri, M, Pompeo, F, Ingurgio, Nc, Carini, V, Coco, R, Giunta, G, Leonardi, G, Randazzo, V, Di Blasi, V, Tamburino, C, Russo, G, Mangiameli, S, Cardillo, R, Castelli, D, Inserra, V, Arena, A, Gulizia, Mm, Raciti, S, Rapisarda, G, Romano, R, Prestifilippo, P, Braschi, Gb, Ledda, G, Terrazzino, R, De Caro, M, Scilabra, G, Graffagnino, B, Grassi, R, Scimone, Gf, Vasquez, L, Coppolino, C, Casale, A, Castelli, M, D'Urso, G, D'Antonio, E, Presti, Ll, Badalamenti, E, Conti, P, Sanfilippo, N, Cirrincione, V, Cinà, Mt, Cusimano, G, Taormina, A, Giuliano, P, Bajardi, A, Mandala, V, Canonico, A, Geraci, G, Sabella, Fp, Enia, F, Floresta, Am, Cascio, Il, Gumina, D, Cavallaro, A, Piccione, G, Ferrante, R, Blandino, M, Iudicello, Ms, Mossuti, E, Romano, G, Lombardo, L, Monastra, P, Di Vincenzo, D, Orru, P, Muscas, F, Giardina, G, Corda, M, Locci, G, Podda, A, Ledda, M, Siddi, P, Lai, C, Pili, G, Mercuro, G, Mureddu, G, Ganau, A, Meloni, G, Poddighe, G, Sanna, G., Cosmi, Franco, Di Giulio, Paola, Masson, Serge, Finzi, Andrea, Marfisi, Rosa Maria, Cosmi, Deborah, Scarano, Marco, Tognoni, Gianni, Maggioni, Aldo P, Porcu, Maurizio, Boni, Silvana, Cutrupi, Giovanni, Tavazzi, Luigi, Latini, Roberto, on behalf of the GISSI-HF, Investigator, Margonato, Alberto, DI GIULIO, Paola, Maggioni, Aldo P., GISSI HF, Investigator, and Sinagra, Gianfranco

Subjects
Male, Health Status, Left, Wine, Comorbidity, Ventricular Function, Left, Health Statu, Quality of life, Risk Factors, Surveys and Questionnaires, Prevalence, Ventricular Function, Surveys and Questionnaire, Depression (differential diagnoses), Depression, Medicine (all), Middle Aged, Prognosis, biological marker, Italy, Female, Risk assessment, Cardiology and Cardiovascular Medicine, biological markers, Human, Cardiac function curve, Vasculitis, medicine.medical_specialty, Vasculiti, Alcohol Drinking, Prognosi, Lower risk, Risk Assessment, Internal medicine, medicine, Humans, Protective Factor, Aged, Heart Failure, business.industry, Risk Factor, Stroke Volume, Biomarker, quality of life, wine, aged, alcohol drinking, biomarkers, chronic disease, comorbidity, depression, female, heart failure, humans, italy, male, middle aged, prevalence, prognosis, protective factors, risk assessment, risk factors, stroke volume, surveys and questionnaires, vasculitis, ventricular function, left, health status, cardiology and cardiovascular medicine, Biomarkers, Chronic Disease, Protective Factors, Quality of Life, medicine.disease, Clinical trial, Heart failure, Physical therapy, business
Abstract

Background— Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results— A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell’Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P P =0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P P =0.01) after adjusting for possible confounders. Conclusions— We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT0033633.

Published
2015

36. Memoria, cultura e identità nell'ecumene globale

Author

De Mauro T, Melazzo L, Lo PIparo F, Lo Cascio V, Mandalà M, D'Onofrio S, Petrone G, Borghini A, Ponzio A, Bravo GL, Di Sparti A, Dondoli L, Ferroni G, Caprettini GP, Marrone G, Ricci P, Ruffino G, Tomasino R, Calabrese O, Bonacasa N, Di Natale MC, La Barbera S, Ruta Am, Pagano R, Lavagnini R, DI Stefano G, Ruta MC, Cancelliere E, Urrutia J, Guzzetta A, Carapezza A, Auteri L, Brodersen M, Rinaldi MG, Giusti S, Scafoglio D, Sole A, Tedesco N, Messineo Sacco M, Buttitta E, La Fauci N, Rubino A, Santangelo G, Tusa S, Marino R, Brugnone A, Anello P, Sunseri G, Cardini F, D'Alessandro V, Buccellato Dentici R, Cancilia O, Butera S, Canfora L, Eco U, Harrison G, Callari Galli M, Signorelli A, Guarrasi V, Lombardi Satriani L, D'Ippolito V, Miceli S, Seppilli T, Giacomarra M, Montes S, Giallombardo F, Del Ninno M, Herzfeld M, MOrello G, Salvioni G, Cusimano G, Angostaro G, Morino C, Lendinara P, Nicosia S, Canova G, Corrao F, Giordano F, Atzori M, Petrarca V, Pellegrini A, Lastra Y, Sherzer J, Sherzer D, Lupo A, Rotolo V, Angioni G, Trupia J, Di Bella MP, Cavalcanti O, Guggino E, Faeta F, Buttitta I, Grimaldi P, Satta M, Bonazinga S, Aiello P, Li Vigni P, Tusa V, Sorgi O, Varvaro A, Vibak J, Puglisi G, Bettetini G, Russo A, Ruta M T, Matera, V, MATERA, VINCENZO, De Mauro T, Melazzo L, Lo PIparo F, Lo Cascio V, Mandalà M, D'Onofrio S, Petrone G, Borghini A, Ponzio A, Bravo GL, Di Sparti A, Dondoli L, Ferroni G, Caprettini GP, Marrone G, Ricci P, Ruffino G, Tomasino R, Calabrese O, Bonacasa N, Di Natale MC, La Barbera S, Ruta Am, Pagano R, Lavagnini R, DI Stefano G, Ruta MC, Cancelliere E, Urrutia J, Guzzetta A, Carapezza A, Auteri L, Brodersen M, Rinaldi MG, Giusti S, Scafoglio D, Sole A, Tedesco N, Messineo Sacco M, Buttitta E, La Fauci N, Rubino A, Santangelo G, Tusa S, Marino R, Brugnone A, Anello P, Sunseri G, Cardini F, D'Alessandro V, Buccellato Dentici R, Cancilia O, Butera S, Canfora L, Eco U, Harrison G, Callari Galli M, Signorelli A, Guarrasi V, Lombardi Satriani L, D'Ippolito V, Miceli S, Seppilli T, Giacomarra M, Montes S, Giallombardo F, Del Ninno M, Herzfeld M, MOrello G, Salvioni G, Cusimano G, Angostaro G, Morino C, Lendinara P, Nicosia S, Canova G, Corrao F, Giordano F, Atzori M, Petrarca V, Pellegrini A, Lastra Y, Sherzer J, Sherzer D, Lupo A, Rotolo V, Angioni G, Trupia J, Di Bella MP, Cavalcanti O, Guggino E, Faeta F, Buttitta I, Grimaldi P, Satta M, Bonazinga S, Aiello P, Li Vigni P, Tusa V, Sorgi O, Varvaro A, Vibak J, Puglisi G, Bettetini G, Russo A, Ruta M T, Matera, V, and MATERA, VINCENZO

Published
2005

37. Assessment of nitrate contamination risk: The Italian experience

Author

Capri, E., primary, Civita, M., additional, Corniello, A., additional, Cusimano, G., additional, De Maio, M., additional, Ducci, D., additional, Fait, G., additional, Fiorucci, A., additional, Hauser, S., additional, Pisciotta, A., additional, Pranzini, G., additional, Trevisan, M., additional, Delgado Huertas, A., additional, Ferrari, F., additional, Frullini, R., additional, Nisi, B., additional, Offi, M., additional, Vaselli, O., additional, and Vassallo, M., additional

Published
2009
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46. Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions?

Author

Barer, D H, Pillon, B, Dubois, B, Cusimano, G, Bonnet, A M, Lhermitte, F, and Agid, Y

Subjects
DOPA, DRUG therapy for Parkinson's disease, CELL receptors, COGNITION disorders, COMPARATIVE studies, DOPAMINE, FRONTAL lobe, NEUROPSYCHOLOGICAL tests, RESEARCH methodology, MEDICAL cooperation, MOTOR ability, PARKINSON'S disease, RESEARCH, EVALUATION research, THERAPEUTICS, CELL physiology
Abstract

In order to investigate the neuronal basis of cognitive disorders in Parkinson's disease, the neuropsychological performance of 120 patients with idiopathic Parkinson's disease was analysed in relation to motor symptoms as a function of their response to levodopa. Cognitive impairment was poorly correlated with akinesia and rigidity, symptoms which respond well to levodopa treatment, and was not correlated at all with that part of the patients' motor score that could be improved by the drug. In contrast, strong correlations were found between all neuropsychological test scores and axial symptoms such as gait disorder and dysarthria, which respond little if at all to levodopa treatment. The neuropsychological test scores were also strongly correlated with the motor score of patients estimated when clinical improvement was maximal under levodopa treatment. This score is assumed to represent residual non-dopaminergic motor dysfunctions. The correlations suggest that much of the cognitive impairment in Parkinson's disease results from the dysfunction of non-dopaminergic neuronal systems. [ABSTRACT FROM AUTHOR]

Published
1989

47. Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions?

Author

Pillon, B, Dubois, B, Cusimano, G, Bonnet, A M, Lhermitte, F, and Agid, Y

Subjects
DOPA, DRUG therapy for Parkinson's disease, CELL receptors, COGNITION disorders, COMPARATIVE studies, DOPAMINE, FRONTAL lobe, NEUROPSYCHOLOGICAL tests, RESEARCH methodology, MEDICAL cooperation, MOTOR ability, PARKINSON'S disease, RESEARCH, EVALUATION research, THERAPEUTICS, CELL physiology
Abstract

In order to investigate the neuronal basis of cognitive disorders in Parkinson's disease, the neuropsychological performance of 120 patients with idiopathic Parkinson's disease was analysed in relation to motor symptoms as a function of their response to levodopa. Cognitive impairment was poorly correlated with akinesia and rigidity, symptoms which respond well to levodopa treatment, and was not correlated at all with that part of the patients' motor score that could be improved by the drug. In contrast, strong correlations were found between all neuropsychological test scores and axial symptoms such as gait disorder and dysarthria, which respond little if at all to levodopa treatment. The neuropsychological test scores were also strongly correlated with the motor score of patients estimated when clinical improvement was maximal under levodopa treatment. This score is assumed to represent residual non-dopaminergic motor dysfunctions. The correlations suggest that much of the cognitive impairment in Parkinson's disease results from the dysfunction of non-dopaminergic neuronal systems. [ABSTRACT FROM AUTHOR]

Published
1989

49. Phospholipid liposomes in depression: a double-blind study versus placebo

Author

G. Meco, Pirro R, Allegro A, Cusimano G, Casacchia M, Marola W, and Di Cesare E

Subjects
Adult, Male, medicine.medical_specialty, Clomipramine, Phospholipid, Placebo, chemistry.chemical_compound, Double-Blind Method, Dopamine, Internal medicine, medicine, Humans, Phospholipids, Aged, Psychiatric Status Rating Scales, Liposome, Depressive Disorder, business.industry, Drug Synergism, General Medicine, Middle Aged, Prolactin, Growth hormone secretion, Endocrinology, chemistry, Liposomes, Female, Onset of action, business, medicine.drug
Abstract

Phospholipid liposomes (PL) are capable of stimulating the activity of dopamine (DA)-sensitive adenylate cyclase in mouse brain, and inducing a modification of the noradrenergic hypothalamic system in rat. Changes of prolactin and growth hormone secretion have been observed in humans given PL. A recent double-blind clinical study suggests that liposomes have a good antidepressive effect in depressive patients. 26 patients with depressive syndrome were included in a double-blind study; 13 patients were treated with clomipramine (CI) + placebo (P), and 13 with CI + PL. The dose of CI was 75 mg orally daily, that of PL was 200 mg by intravenous infusion in 500 ml isotonic saline solution daily. The symptomatology was evaluated on days 0, 7, 14, and 21 using the Hamilton Rating Scale. The results of this controlled trial have shown that both treatment were effective on overall symptomatology but the onset of action of CI + PL was more rapid than CI + P.

Published
1982

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