1. An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications
- Author
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Giulia De Soricellis, Francesco Fagnani, Alessia Colombo, Claudia Dragonetti, Dominique Roberto, Daniele Marinotto, David H. Hartnell, Mark J. Hackett, Massimiliano Massi, Bertrand Carboni, Véronique Guerchais, National Interuniversity Consortium of Materials Science and Technology (INSTM ), Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta' (SCITEC), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Curtin University [Perth], Planning and Transport Research Centre (PATREC), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), National Interuniversity Consortium of Materials Science and Technology [INSTM21MIROBERTO], Universita degli Studi di Milano [PSR2020_DIP_005_PI_ACOLO], Australian Research Council [DP220103091], Fondazione Cariplo and Regione Lombardia, and CNR
- Subjects
Settore CHIM/03 - Chimica Generale e Inorganica ,complexes ,Optical markers ,Cyclometalated iridium(III) phenanthroline ,Phosphorescence ,Process Chemistry and Technology ,General Chemical Engineering ,[SDV]Life Sciences [q-bio] ,Bio-imaging ,[CHIM]Chemical Sciences ,Iridium dyes ,Brain tissue staining - Abstract
International audience; Three novel luminescent iridium(III) dyes functionalized with a tryptophan amino acid and bearing two cyclometalated 2-phenylpyridines, 2-(2,4-difluorophenyl)pyridines or 2-phenylquinolines have been prepared and well characterized. They emit at 522-561 nm with a luminescence quantum yield in the range 0.33-0.98. All the dyes are able to stain neuronal cells in rat cerebellum tissue, as evidenced by fluorescence microscopy, showing affinity for granule neurons. The complexes bearing cyclometalated 2-(2,4-difluorophenyl)pyridines or 2-phenylquinolines also have a good affinity for brain white matter. The dye with two cyclometalated 2-phenylquinolines is characterized by the best luminescence quantum yield (0.98). Besides, giving the greatest image contrast, the dye with two cyclometalated 2-phenylquinolines shows the strongest affinity for a distinct subtype of neurons found in cerebellum tissue, the purkinje neurons (as evidenced with fluorescence microscopy).
- Published
- 2023