1. Cysteine-Cystine Redox Cycling in a Gold–Gold Dual-Plate Generator-Collector Microtrench Sensor
- Author
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Jesús Iniesta, Jules L. Hammond, Stephen J. Green, Nigel Benjamin, Frank Marken, Andrew J. Gross, Paul G. Winyard, C. Peter Winlove, Pedro Estrela, Département de Chimie Moléculaire (DCM), Université Joseph Fourier - Grenoble 1 (UJF)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), University of Alicante, University of Bath [Bath], School of Physics and Astronomy [Exeter], University of Exeter, Universidad de Alicante. Departamento de Química Física, Universidad de Alicante. Instituto Universitario de Electroquímica, and Electroquímica Aplicada y Electrocatálisis
- Subjects
Inorganic chemistry ,Cystine ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Redox ,Analytical Chemistry ,Generator (circuit theory) ,chemistry.chemical_compound ,Adsorption ,Cysteine-cystine redox cycle ,[CHIM]Chemical Sciences ,Cysteine ,Química Física ,Electrodes ,Chemistry ,Electrochemical Techniques ,Equipment Design ,Cysteine + cystine ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Electrode ,Gold ,0210 nano-technology ,Oxidation-Reduction ,Redox cycling ,Gold−gold dual-plate ,Microtrench sensor - Abstract
Thiols and disulfides are ubiquitous and important analytical targets. However, their redox properties, in particular on gold sensor electrodes, are complex and obscured by strong adsorption. Here, a gold–gold dual-plate microtrench dual-electrode sensor with feedback signal amplification is demonstrated to give well-defined (but kinetically limited) steady-state voltammetric current responses for the cysteine-cystine redox cycle in nondegassed aqueous buffer media at pH 7 down to micromolar concentration levels. J.L.H. is supported by an U.K. Engineering and Physical Sciences Research Council (EPSRC) Doctoral Training Award. A.J.G. and F.M. gratefully acknowledge EPSRC funding (Grant EP/I028706/1).
- Published
- 2014
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