37 results on '"Czich, Andreas"'
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2. Assessment of the performance of the Ames MPF™ assay: A multicenter collaborative study with six coded chemicals
3. Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs)
4. A weight of evidence review of the genotoxicity of titanium dioxide (TiO2)
5. Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines
6. Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Rodent Carcinogenic Potency
7. Use of less-than-lifetime (LTL) durational limits for nitrosamines: Case study of N-Nitrosodiethylamine (NDEA)
8. Assessment of the performance of the Ames MPF™ assay: A multicenter collaborative study with six coded chemicals
9. Predicting DNA-Reactivity of N-Nitrosamines: A Quantum Chemical Approach
10. Genotoxicity
11. Genotoxicity
12. Improvement of in vivo genotoxicity assessment: Combination of acute tests and integration into standard toxicity testing
13. Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies
14. Predictive in silico off-target profiling in drug discovery
15. Follow-up actions from positive results of in vitro genetic toxicity testing
16. Computational Investigation of Drug Phototoxicity: Photosafety Assessment, Photo-Toxophore Identification, and Machine Learning
17. Optimizing drug discovery by Investigative Toxicology: Current and future trends
18. A critical appraisal of the sensitivity of in vivo genotoxicity assays in detecting human carcinogens
19. Case study: Identification of off/on target mechanisms effects inducing genotoxicty
20. Mode-of-toxicity prediction for molecular design in the pharmaceutical industry
21. Optimizing Drug Discovery by Investigative Toxicology: Current and Future Trends.
22. ZFminus1: A strategy to reduce animal tests for developmental toxicity testing by a combined use of mammalian models and the zebrafish embryotoxicity test (ZFET or ZETA). Selection of model compounds
23. Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats
24. An inter-laboratory validation of the zebrafish embryo assay for the detection of developmental toxicity
25. Computational Models for Human and Animal Hepatotoxicity with a Global Application Scope
26. Do Carboxylic/Sulfonic Acid Halides Really Present a Mutagenic and Carcinogenic Risk as Impurities in Final Drug Products?
27. Computational prediction of off-target related safety liabilities of molecules: Cardiotoxicity, hepatotoxicity and reproductive toxicity
28. Teriflunomide: Non-Clinical Evaluation Demonstrates No Effect On Sperm DNA or Male Fertility (P2.233)
29. Leveraging early pharmacology studies and animal models of human disease to learn about toxicity
30. Follow-up actions from positive results of in vitro genetic toxicity testing
31. Photochemical genotoxicity: principles and test methods
32. Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases
33. Activation of benzylic alcohols to mutagens by rat and human sulfotransferases expressed in Escherichia coli
34. Stable Expression of Heterologous Sulfotransferase in V79 Cells: Activation of Primary and Secondary Benzylic Alcohols
35. 1-hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects
36. Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continuous cell cultures
37. Stable Expression of Heterologous Sulfotransferase in V79 Cells: Activation of Primary and Secondary Benzylic Alcohols.
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