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4. Softening the ultra-stiff: controlled variation of Young's modulus in single crystal diamond

Author

Battiato, A., Lorusso, M., Bernardi, E., Picollo, F., Bosia, F., Ugues, D., Zelferino, A., Damin, A., Baima, J., Pugno, N. M., Ambrosio, E. P., and Olivero, P.

Subjects
Condensed Matter - Materials Science
Abstract

A combined experimental and numerical study on the variation of the elastic properties of defective single-crystal diamond is presented for the first time, by comparing nano-indentation measurements on MeV-ion-implanted samples with multi-scale modeling consisting of both ab initio atomistic calculations and meso-scale Finite Element Method (FEM) simulations. It is found that by locally introducing defects in the 2x10^18 - 5x10^21 cm-3 density range, a significant reduction of, as well as of density, can be induced in the diamond crystal structure without incurring in the graphitization of the material. Ab initio atomistic simulations confirm the experimental findings with a good degree of confidence. FEM simulations are further employed to verify the consistency of measured deformations with a stiffness reduction, and to derive strain and stress levels in the implanted region. Combining these experimental and numerical results, we also provide insight into the mechanism responsible for the depth dependence of the graphitization threshold in diamond. This work prospects the possibility of achieving accurate tunability of the mechanical properties of single-crystal diamond through defect engineering, with significant technological applications, i.e. the fabrication and control of the resonant frequency of diamond-based micromechanical resonators., Comment: 32 pages, 7 figures

Published
2016
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5. One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial.

Author

Luciano, M., Sampogna, G., D'Ambrosio, E., Rampino, A., Amore, M., Calcagno, P., Rossi, A., Rossi, R., Carmassi, C., Dell'Osso, L., Bianciardi, E., Siracusano, A., Della Rocca, Bianca, Di Vincenzo, M., Del Vecchio, Valeria, Malangone, Claudio, Mancuso, Emiliana, Toni, Claudia, Volpicelli, Antonio, and Andriola, Ileana

Subjects
MENTAL illness, PEOPLE with mental illness, RANDOMIZED controlled trials, MENTAL health, BODY mass index
Abstract

This multicentric randomized controlled trial (RCT), carried out in six Italian University mental health sites, aims to test the efficacy of a six-month psychosocial intervention (LYFESTYLE) on Body Mass Index (BMI), body weight, waist circumference, fasting glucose, triglycerides, cholesterol, Framingham and HOmeostasis Model Assessment of insulin resistance (HOMA-IR) indexes in patients with schizophrenia, bipolar disorder, and major depression. Moreover, the efficacy of the intervention has also been tested on several other physical and mental health domains. Patients were randomly allocated to receive the six-month experimental intervention (LIFESTYLE) or a behavioural control intervention. All enrolled patients were assessed at baseline and after one year. We recruited 401 patients (206 in the experimental and 195 in the control group) with a diagnosis of schizophrenia or other psychotic disorder (29.9%), bipolar disorder (43.3%), or major depression (26.9%). At one year, patients receiving the experimental intervention reported an improvement in body mass index, body weight, waist circumference, HOMA-IR index, anxiety and depressive symptoms and in quality of life. Our findings confirm the efficacy of the LIFESTYLE intervention in improving physical and mental health-related outcomes in patients with severe mental illnesses after one year. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Disorganization and real-world functioning in schizophrenia: Results from the multicenter study of the Italian Network for Research on Psychoses

Author

Bracale, Nadja, Cardillo, Simona, Brasso, Claudio, Andriola, Ileana, Romano, Raffaella, Caforio, Grazia, Barlati, Stefano, Galluzzo, Alessandro, Deste, Giacomo, Pinna, Federica, Lostia di S. Sofia, Silvia, Lai, Alice, Signorelli, Maria Salvina, Corbo, Mariangela, Baroni, Gaia, Lupi, Matteo, Altamura, Mario, La Montagna, Maddalena, Malerba, Stefania, Murri, Martino Belvederi, Corso, Alessandro, Bugliani, Michele, Pizziconi, Giulia, Rossi, Rodolfo, Serrone, Dario, Giusti, Laura, Ussorio, Donatella, Salza, Anna, Merlotti, Eleonora, Piegari, Giuseppe, Patriarca, Sara, Pietrafesa, Daria, de Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Marangon, Debora, Grottaroli, Marika, Pigoni, Alessandro, Grassi, Silvia, Cremonese, Carla, Meneguzzo, Paolo, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Gesi, Camilla, Cremone, IvanMirko, Carpita, Barbara, Brugnoli, Roberto, Comparelli, Anna, Corigliano, Valentina, Di Fabio, Fabio, Buzzanca, Antonio, Girardi, Nicoletta, Niolu, Cinzia, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Rocca, P., Galderisi, S., Rossi, A., Bertolino, A., Rucci, P., Gibertoni, D., Montemagni, C., Bellino, S., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Cuomo, A., D'Ambrosio, E., dell'Osso, L., Girardi, P., Marchesi, C., Monteleone, P., Montemitro, C., Oldani, L., Pacitti, F., Roncone, R., Siracusano, A., Tenconi, E., Vita, A., Zeppegno, P., Steardo, L., Jr, Vignapiano, A., and Maj, M.

Published
2018
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8. Three-dimensional numerical investigation of a suspension flow in an eccentric Couette flow geometry.

Author

Badia, A., D'Ambrosio, E., D'Angelo, Y., Peters, F., and Lobry, L.

Subjects
*COUETTE flow, *NEWTONIAN fluids, *GRANULAR flow, *GEOMETRY, *COMPUTER simulation, *NON-Newtonian fluids
Abstract

This paper investigates the influence of eccentricity on flow characteristics and particle migration in Couette geometries. The study involves numerical simulations using the recent frame-invariant model developed by Badia et al. [J. Non-Newtonian Fluid Mech. 309, 104904 (2022)]. The study begins with a two-dimensional analysis, focusing first on the Newtonian fluid in order to thoroughly characterize the specific properties of this flow configuration. Next, the impact of eccentricity on particle migration in an isodense suspension is examined by numerical simulations based on the experiments conducted by Subia et al. [J. Fluid Mech. 373, 193–219 (1998)]. Furthermore, the study is extended to include a full three-dimensional analysis of a dense suspension flow in an eccentric Couette geometry based on resuspension experiments conducted by Saint-Michel et al. [Phys. Fluids 31, 103301 (2019)] and D'Ambrosio et al.[J. Fluid Mech. 911, A22 (2021)]. The main objective of the latter study is to investigate the influence of eccentricity on the resuspension height and on the calculation of the particle normal stress in the vertical direction through the volume fraction profile analysis. Our results show that even minimal eccentricity can lead to significant changes compared to the centered case. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Model of Thermal Wavefront Distortion in Interferometric Gravitational-Wave Detectors I: Thermal Focusing

Author

Beausoleil, R. G., D'Ambrosio, E., Kells, W., Camp, J., Gustafson, E K., and Fejer, M. M.

Subjects
General Relativity and Quantum Cosmology
Abstract

We develop a steady-state analytical and numerical model of the optical response of power-recycled Fabry-Perot Michelson laser gravitational-wave detectors to thermal focusing in optical substrates. We assume that the thermal distortions are small enough that we can represent the unperturbed intracavity field anywhere in the detector as a linear combination of basis functions related to the eigenmodes of one of the Fabry-Perot arm cavities, and we take great care to preserve numerically the nearly ideal longitudinal phase resonance conditions that would otherwise be provided by an external servo-locking control system. We have included the effects of nonlinear thermal focusing due to power absorption in both the substrates and coatings of the mirrors and beamsplitter, the effects of a finite mismatch between the curvatures of the laser wavefront and the mirror surface, and the diffraction by the mirror aperture at each instance of reflection and transmission. We demonstrate a detailed numerical example of this model using the MATLAB program Melody for the initial LIGO detector in the Hermite-Gauss basis, and compare the resulting computations of intracavity fields in two special cases with those of a fast Fourier transform field propagation model. Additional systematic perturbations (e.g., mirror tilt, thermoelastic surface deformations, and other optical imperfections) can be included easily by incorporating the appropriate operators into the transfer matrices describing reflection and transmission for the mirrors and beamsplitter., Comment: 24 pages, 22 figures. Submitted to JOSA B

Published
2002
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10. Japanese reverse glass painting : the other East Asian tradition

Author

Thomsen, Hans B, Giese, Francine; https://orcid.org/0000-0001-5493-1159, Ambrosio, Elisa, Martimyanova, Alina, Thomsen, H B ( Hans B ), Giese, F ( Francine ), Ambrosio, E ( Elisa ), Martimyanova, A ( Alina ), Thomsen, Hans B, Giese, Francine; https://orcid.org/0000-0001-5493-1159, Ambrosio, Elisa, Martimyanova, Alina, Thomsen, H B ( Hans B ), Giese, F ( Francine ), Ambrosio, E ( Elisa ), and Martimyanova, A ( Alina )

Abstract

The essay outlines the Japanese tradition of reverse glass painting, looking at both textual evidence as well as extant objects from the three early modern production centers: Nagasaki, Osaka, and Edo. A knowledge transfer from Dutch and Chinese traditions of reverse glass painting initially took place through the city of Nagasaki, where a number of local artists received aspects from both traditions and created a new genre of Japanese art. In time, this art form spread to other parts of Japan, where it took on themes typically seen in Japanese visual media, such as beautiful women, kabuki actors, and landscapes. The inter-medial con-nections to the woodblock prints became a key part of the Japanese tradition of reverse glass painting and, with the advent of new media in the latter part of the nineteenth century, pho-tography became incorporated into the art form.

Published
2023

16. Concordance between vascular plant and macrofungal community composition in broadleaf deciduous forests in central Italy

Author

Landi M, Salerni E, Ambrosio E, D’Aguanno M, Nucci A, Saveri C, Perini C, and Angiolini C

Subjects
Deciduous Oaks, Ectomycorrhizal Fungi, Host Specificity, Saprotrophic Fungi, Surrogates, Trophic Groups, Forestry, SD1-669.5
Abstract

We examined the concordance between vascular plants and macrofungi (grouped into trophic groups) in Mediterranean forest habitats (central Italy). Our goal was to test how consistently plant and fungi groups classify plots in a broadleaf deciduous forest dominated by Quercus cerris. Our hypothesis was that groups of plants can be used as surrogates for the classification of macrofungal communities. The test of concordance comprised two steps: 1) the plant species data sets were subjected to cluster analysis, to obtain three classifications based on presence of all plants, presence and frequency of only woody species; 2) Multiple Response Permutation Procedures (MRPP) was used to test the performance of each plant classification applied to the fungi data sets. The sample scores along the first PCA axis was used to investigate the relationships between compositional patterns. In the concordance analysis, the classification of only woody plants provided better results than the classification obtained with herbaceous and woody plants together. Cross-tests gave the best results when the “woody plants” classification was applied to ectomycorrhizal fungi (EMF) and, to a certain extent, to humicolous saprotrophs (Sh). The ordination analysis indicated that the frequency of woody plants follows a similar spatial distribution to EMF and Sh fungal groups and is therefore expected to discriminate the same environmental gradients. Many EMF exhibit preferences for few (one or two) hosts. Significant associations were found among a greater number of EMF and woody plant species. Woody plants such as Sorbus domestica and Prunus spinosa appear to be associated with many EMF. The combination of a high frequency of Fraxinus oxycarpa and Quercus petraea seems to promote distinct assemblages of EMF and Sh fungi. Then, characteristic assemblages of fungi were found in association with certain tree and shrub combinations.

Published
2015
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19. The Complex Interplay Between Physical Activity and Recovery Styles in Patients With Severe Mental Disorders in a Real-World Multicentric Study

Author

Sampogna, G, Luciano, M, Di Vincenzo, M, Andriola, I, D'Ambrosio, E, Amore, M, Serafini, G, Rossi, A, Carmassi, C, Dell'Osso, L, Di Lorenzo, G, Siracusano, A, Rossi, R, Fiorillo, A, Working Group LIFESTYLE, Bianciardi, E, Sampogna, Gaia, Luciano, Mario, Di Vincenzo, Matteo, Andriola, Ileana, D'Ambrosio, Enrico, Amore, Mario, Serafini, Gianluca, Rossi, Alessandro, Carmassi, Claudia, Dell'Osso, Liliana, Di Lorenzo, Giorgio, Siracusano, Alberto, Rossi, Rodolfo, and Fiorillo, Andrea

Subjects
Psychiatry and Mental health, lifestyle, sedentary behaviors, Settore MED/25, sedentary behavior, physical activity, severe mental disorders, mortality
Abstract

Compared with the general population, people with severe mental disorders have significantly worse physical health and a higher mortality rate, which is partially due to the adoption of unhealthy lifestyle behaviors, such as heavy smoking, use of alcohol or illicit drugs, unbalanced diet, and physical inactivity. These unhealthy behaviors may also play a significant role in the personal and functional recovery of patients with severe mental disorders, although this relationship has been rarely investigated in methodologically robust studies. In this paper, we aim to: a) describe the levels of physical activity and recovery style in a sample of patients with severe mental disorders; b) identify the clinical, social, and illness-related factors that predict the likelihood of patients performing physical activity. The global sample consists of 401 patients, with a main psychiatric diagnosis of bipolar disorder (43.4%, N = 174), psychosis spectrum disorder (29.7%; N = 119), or major depression (26.9%; N = 118). 29.4% (N = 119) of patients reported performing physical activity regularly, most frequently walking (52.1%, N = 62), going to the gym (21.8%, N = 26), and running (10.9%, N = 13). Only 15 patients (3.7%) performed at least 75 min of vigorous physical activity per week. 46.8% of patients adopted sealing over as a recovery style and 37.9% used a mixed style toward integration. Recovery style is influenced by gender (p < 0.05) and age (p < 0.05). The probability to practice regular physical activity is higher in patients with metabolic syndrome (Odds Ratio - OR: 2.1; Confidence Interval - CI 95%: 1.2-3.5; p < 0.050), and significantly lower in those with higher levels of anxiety/depressive symptoms (OR: 0.877; CI 95%: 0.771-0.998; p < 0.01). Globally, patients with severe mental disorders report low levels of physical activities, which are associated with poor recovery styles. Psychoeducational interventions aimed at increasing patients' motivation to adopt healthy lifestyle behaviors and modifying recovery styles may improve the physical health of people with severe mental disorders thus reducing the mortality rates.

Published
2022

22. Prevalence of antipsychotic-induced extrapyramidal symptoms and their association with neurocognition and social cognition in outpatients with schizophrenia in the 'real-life'

Author

Monteleone, P., Cascino, G., Monteleone, A. M., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Collantoni, E., Corrivetti, G., Cuomo, A., Bellomo, A., D'Ambrosio, E., Dell'Osso, L., Frascarelli, M., Giordano, G. M., Giuliani, L., Marchesi, C., Montemagni, C., Oldani, L., Pinna, F., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., Maj, M., Del Buono, G., Marciello, F., Di Palo, P., Sangiuliano, M., Di Gioia, C., Barlati, S., Deste, G., Turrina, C., Carpiniello, B., Marras, L., Muscas, M., Bucci, P., Piegari, G., Brando, F., Aiello, C., Poli, L. F., Saitta, G., Surace, T., Altamura, M., Malerba, S., Padalino, F., Calcagno, P., Murri, M. B., Escelsior, A., Giusti, L., Bianchini, V., Salza, A., Pacitti, F., Socci, V., Lucaselli, A., De Bartolomeis, A., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Cremone, I. M., Carpita, B., Biondi, M., Di Fabio, F., Accinni, T., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Ribolsi, M., Niolu, C., Brasso, C., Riccardi, C., Del Favero, E., Monteleone, P., Cascino, G., Monteleone, A. M., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Collantoni, E., Corrivetti, G., Cuomo, A., Bellomo, A., D'Ambrosio, E., Dell'Osso, L., Frascarelli, M., Giordano, G. M., Giuliani, L., Marchesi, C., Montemagni, C., Oldani, L., Pinna, F., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., and Maj, M.

Subjects
Adult, Male, Social Cognition, Extrapyramidal symptoms, Chlorpromazine, medicine.medical_treatment, Antipsychotic, 03 medical and health sciences, 0302 clinical medicine, Cognition, Basal Ganglia Diseases, Social cognition, Prevalence, Medicine, Antipsychotics, Humans, Extrapyramidal symptom, Neurocognition, Biological Psychiatry, Pharmacology, business.industry, Parkinsonism, Middle Aged, medicine.disease, Risperidone, 030227 psychiatry, Settore MED/25, Schizophrenia, Female, Schizophrenic Psychology, medicine.symptom, business, Neurocognitive, Antipsychotic Agents, Psychopathology, Clinical psychology
Abstract

First generation antipsychotics (FGAs) are more likely to induce extrapyramidal side-effects (EPS) than second generation antipsychotics (SGAs), and EPS have been shown associated to cognitive deficits in schizophrenia. So far, no study has explored the relationships between EPS and social cognition (SC) in people with schizophrenia. Therefore, we assessed the prevalence of EPS in a large sample of drug-treated community-dwelling persons with schizophrenia and explored their relationships with patients' neurocognitive and SC abilities. 875 patients underwent EPS, psychopathological, neurocognitive and SC assessments by means of standardized measures. Relationships between EPS, psychopathology and neurocognitive and SC measures were investigated by correlation tests. Moreover, a partial correlation network was computed by means of a network analysis. 256 patients were treated with FGAs alone or in combination with SGA and 619 with SGAs. EPS were significantly more frequent in FGA-treated group than in the SGA-treated one. Patients with EPS disclosed a more severe psychopathology and were more impaired in neurocognitive and SC measures compared to those without EPS. Disorganization, expressive deficit, and duration of illness were significantly associated to both neurocognitive and SC measures while EPS were associated to neurocognitive measures only. The network analysis showed that parkinsonism was the sole EPS directly connected to both psychopathological and neurocognitive indices whereas no direct connection emerged between EPS and SC measures. Present findings confirm that EPS are still present in the era of SGAs and contribute, together with other clinical variables, to the neurocognitive but not to the SC impairment of patients with schizophrenia.

Published
2021

25. The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study

Author

Vita, A., Barlati, S., Deste, G., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Collantoni, E., Cuomo, A., D'Ambrosio, E., dell' Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Zeppegno, P., Nibbio, G., Galderisi, S., Maj, M., Ceraso, A., Galluzzo, A., Lisoni, J., Di Palo, P., Papalino, M., Romano, R., Pinna, F., Lai, A., di Santa Sofia, S. L., Bucci, P., Piegari, G., Brando, F., Giuliani, L., Signorelli, M. S., Poli, L. F., Martinotti, G., Pettorruso, M., Montemitro, C., Altamura, M., Malerba, S., Padalino, F., Amerio, A., Cal-Cagno, P., Zampogna, D., Giusti, L., Salza, A., Mammarella, S., Pacitti, F., Socci, V., Talevi, D., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Gesi, C., Carpita, B., Corrivetti, G., Cascino, G., del Buono, G., Di Fabio, F., Buzzanca, A., Girardi, N., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Brasso, C., Riccardi, C., Del Favero, E., Vita, A., Barlati, S., Deste, G., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Collantoni, E., Cuomo, A., D'Ambrosio, E., dell' Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Zeppegno, P., Nibbio, G., Galderisi, S., Maj, M., Ceraso, A., Galluzzo, A., Lisoni, J., Di Palo, P., Papalino, M., Romano, R., Pinna, F., Lai, A., di Santa Sofia, S. L., Bucci, P., Piegari, G., Brando, F., Giuliani, L., Signorelli, M. S., Poli, L. F., Martinotti, G., Pettorruso, M., Montemitro, C., Altamura, M., Malerba, S., Padalino, F., Amerio, A., Cal-Cagno, P., Zampogna, D., Giusti, L., Salza, A., Mammarella, S., Pacitti, F., Socci, V., Talevi, D., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Gesi, C., Carpita, B., Corrivetti, G., Cascino, G., del Buono, G., Di Fabio, F., Buzzanca, A., Girardi, N., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Brasso, C., Riccardi, C., and Del Favero, E.

Subjects
schizophrenia, autism spectrum disorders, cognition, psychosocial functioning, social cognition, Adult, Male, Social Cognition, Interpersonal Relation, autism spectrum disorders, cognition, psychosocial functioning, schizophrenia, social cognition, Disease, Autism spectrum disorders, Cognition, Psychosocial functioning, Schizophrenia, Social cognition, Psychotic Disorder, behavioral disciplines and activities, 03 medical and health sciences, Interpersonal relationship, 0302 clinical medicine, mental disorders, Medicine, Humans, Interpersonal Relations, Autism spectrum disorder, Autistic Disorder, business.industry, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Multicenter study, Settore MED/25, Italy, Psychotic Disorders, Autism, Female, Verbal memory, business, 030217 neurology & neurosurgery, Research Article, Clinical psychology, Human
Abstract

Background Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. Aims To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. Methods The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. Results Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p p Conclusions These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD.

Published
2020

27. 3D Synaptic Organization of the Rat CA1 and Alterations Induced by Cocaine Self-Administration

Author

Ministerio de Ciencia e Innovación (España), Ministerio de Sanidad, Servicios Sociales e Igualdad (España), Plan Nacional sobre Drogas (España), Universidad Nacional de Educación a Distancia (España), European Commission, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Ministerio de Ciencia, Innovación y Universidades (España), Cajal Blue Brain, Ministerio de Educación, Cultura y Deporte (España), Blázquez-Llorca, Lidia, Miguéns, Miguel, Montero-Crespo, M., Selvas, A., González-Soriano, Juncal, Ambrosio, E., DeFelipe, Javier, Ministerio de Ciencia e Innovación (España), Ministerio de Sanidad, Servicios Sociales e Igualdad (España), Plan Nacional sobre Drogas (España), Universidad Nacional de Educación a Distancia (España), European Commission, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Ministerio de Ciencia, Innovación y Universidades (España), Cajal Blue Brain, Ministerio de Educación, Cultura y Deporte (España), Blázquez-Llorca, Lidia, Miguéns, Miguel, Montero-Crespo, M., Selvas, A., González-Soriano, Juncal, Ambrosio, E., and DeFelipe, Javier

Abstract

The hippocampus plays a key role in contextual conditioning and has been proposed as an important component of the cocaine addiction brain circuit. To gain knowledge about cocaine-induced alterations in this circuit, we used focused ion beam milling/scanning electron microscopy to reveal and quantify the three-dimensional synaptic organization of the neuropil of the stratum radiatum of the rat CA1, under normal circumstances and after cocaine-self administration (SA). Most synapses are asymmetric (excitatory), macular-shaped, and in contact with dendritic spine heads. After cocaine-SA, the size and the complexity of the shape of both asymmetric and symmetric (inhibitory) synapses increased but no changes were observed in the synaptic density. This work constitutes the first detailed report on the 3D synaptic organization in the stratum radiatum of the CA1 field of cocaine-SA rats. Our data contribute to the elucidation of the normal and altered synaptic organization of the hippocampus, which is crucial for better understanding the neurobiological mechanisms underlying cocaine addiction.

Published
2021

32. DAYLIGHTING RIVERS PROJECT METHODOLOGY FOR INQUIRY BASED LEARNING

Author

Ugolini F., Barbera G.G., Cavas B., D'Ambrosio E., Di Grazia S., Germán Escudero M., Marrazzo L., Massetti L., Mylonas D., Ozdem-Yilmaz Y., Papageorgiou F., Pearlmutter D., Ungaro F., and Striano V.

Subjects
ICT in education, secondary schools, Inquiry Based Learning, river science
Abstract

The European project Daylighting Rivers, co-funded by the Erasmus+ Programme, aimed at raising students' awareness and interest toward STEM (Science, Technology, Engineering and Math) in secondary education, by making connections between the school curriculum and the local territory on issues connected to rivers - with special emphasis on urban rivers - in Italy, Greece, Spain and Turkey. In order to raise awareness of appropriate urban planning, which recognises the importance of open rivers, a series of scientific inquiry activities was developed by teams of scientists and teachers to investigate different aspects connected to water and river basins. Rivers located in the areas of the Daylighting Rivers partner-schools became the particular objects of investigation by the teams of students. The methodology used in the project is based on Pedaste's model of inquiry-based learning (IBL), a flexible five-step learning cycle that engages students in multidisciplinary scientific investigation - and employs information technologies for the knowledge and the promotion of the territory. This paper describes the learning methodology that has been applied by more than 200 students in the project countries.

Published
2020
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33. Generation of a flat-top laser beam for gravitational wave detectors by means of a nonspherical Fabry-Perot resonator

Author

Tarallo, Marco G., Miller, John, Agresti, J., D'Ambrosio, E., DeSalvo, R., Forest, D., Lagrange, B., Mackowsky, J.M., Michel, C., Montorio, J.L., Morgado, N., Pinard, L., Remilleux, A., Simoni, B., and Willems, P.

Subjects
Detectors -- Equipment and supplies, Detectors -- Innovations, Laser beams -- Research, Resonators -- Properties, Astronomy, Physics
Abstract

We have tested a new kind of Fabry-Perot long-baseline optical resonator proposed to reduce the thermal noise sensitivity of gravitational wave interferometric detectors--the 'mesa beam' cavity--whose flat top beam shape is achieved by means of an aspherical end mirror. We present the fundamental mode intensity pattern for this cavity and its distortion due to surface imperfections and tilt misalignments, and contrast the higher order mode patterns to the Gauss-Laguerre modes of a spherical mirror cavity. We discuss the effects of mirror tilts on cavity alignment and locking and present measurements of the mesa beam tilt sensitivity. OCIS codes: 140.4780, 120.2230, 230.0040.

Published
2007

34. Aluminium matrix composites (AMCs) by DMLS

Author

Manfredi, D, primary, Canali, R, additional, Krishnan, M, additional, Ambrosio, E, additional, Calignano, F, additional, Pavese, M, additional, Miranti, L, additional, Belardinelli, S, additional, Biamino, S, additional, and Fino, P, additional

Published
2013
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49. Detector description and performance for the first coincidence observations between LIGO and GEO

Author

Abbott, B., Abbott, R., Adhikari, R., Ageev, A., Allen, B., Amin, R., Anderson, S.B., Anderson, W.G., Araya, M., Armandula, H., Asiri, F., Aufmuth, P., Aulbert, C., Babak, S., Balasubramanian, R., Ballmer, S., Barish, B.C., Barker, D., Barker-Patton, C., Barnes, M., Barr, B., Barton, M.A., Bayer, K., Beausoleil, R., Belczynski, K., Bennett, R., Berukoff, S.J., Betzwieser, J., Bhawal, B., Bilenko, I.A., Billingsley, G., Black, E., Blackburn, K., Bland-Weaver, B., Bochner, B., Bogue, L., Bork, R., Bose, S., Brady, P.R., Braginsky, V.B., Brau, J.E., Brown, D.A., Brozek, S., Bullington, A., Buonanno, A., Burgess, R., Busby, D., Butler, W.E., Byer, R.L., Cadonati, L., Cagnoli, G., Camp, J.B., Cantley, C.A., Cardenas, L., Carter, K., Casey, M.M., Castiglione, J., Chandler, A., Chapsky, J., Charlton, P., Chatterji, S., Chen, Y., Chickarmane, V., Chin, D., Christensen, N., Churches, D., Colacino, C., Coldwell, R., Coles, M., Cook, D., Corbitt, T., Coyne, D., Creighton, J.D.E., Creighton, T.D., Crooks, D.R.M., Csatorday, P., Cusack, B.J., Cutler, C., D'Ambrosio, E., Danzmann, K., Davies, R., Daw, E., DeBra, D., Delker, T., DeSalvo, R., Dhurandar, S., Dı́az, M., Ding, H., Drever, R.W.P., Dupuis, R.J., Ebeling, C., Edlund, J., Ehrens, P., Elliffe, E.J., Etzel, T., Evans, M., Evans, T., Fallnich, C., Farnham, D., Fejer, M.M., Fine, M., Finn, L.S., Flanagan, É., Freise, A., Frey, R., Fritschel, P., Frolov, V., Fyffe, M., Ganezer, K.S., Giaime, J.A., Gillespie, A., Goda, K., González, G., Goßler, S., Grandclément, P., Grant, A., Gray, C., Gretarsson, A.M., Grimmett, D., Grote, H., Grunewald, S., Guenther, M., Gustafson, E., Gustafson, R., Hamilton, W.O., Hammond, M., Hanson, J., Hardham, C., Harry, G., Hartunian, A., Heefner, J., Hefetz, Y., Heinzel, G., Heng, I.S., Hennessy, M., Hepler, N., Heptonstall, A., Heurs, M., Hewitson, M., Hindman, N., Hoang, P., Hough, J., Hrynevych, M., Hua, W., Ingley, R., Ito, M., Itoh, Y., Ivanov, A., Jennrich, O., Johnson, W.W., Johnston, W., Jones, L., Jungwirth, D., Kalogera, V., Katsavounidis, E., Kawabe, K., Kawamura, S., Kells, W., Kern, J., Khan, A., Killbourn, S., Killow, C.J., Kim, C., King, C., King, P., Klimenko, S., Kloevekorn, P., Koranda, S., Kötter, K., Kovalik, J., Kozak, D., Krishnan, B., Landry, M., Langdale, J., Lantz, B., Lawrence, R., Lazzarini, A., Lei, M., Leonhardt, V., Leonor, I., Libbrecht, K., Lindquist, P., Liu, S., Logan, J., Lormand, M., Lubinski, M., Lück, H., Lyons, T.T., Machenschalk, B., MacInnis, M., Mageswaran, M., Mailand, K., Majid, W., Malec, M., Mann, F., Marin, A., Márka, S., Maros, E., Mason, J., Mason, K., Matherny, O., Matone, L., Mavalvala, N., McCarthy, R., McClelland, D.E., McHugh, M., McNamara, P., Mendell, G., Meshkov, S., Messenger, C., Mitrofanov, V.P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Miyoki, S., Mohanty, S., Moreno, G., Mossavi, K., Mours, B., Mueller, G., Mukherjee, S., Myers, J., Nagano, S., Nash, T., Naundorf, H., Nayak, R., Newton, G., Nocera, F., Nutzman, P., Olson, T., O'Reilly, B., J. Ottaway, D., Ottewill, A., Ouimette, D., Overmier, H., Owen, B.J., Papa, M.A., Parameswariah, C., Parameswariah, V., Pedraza, M., Penn, S., Pitkin, M., Plissi, M., Pratt, M., Quetschke, V., Raab, F., Radkins, H., Rahkola, R., Rakhmanov, M., Rao, S.R., Redding, D., Regehr, M.W., Regimbau, T., Reilly, K.T., Reithmaier, K., Reitze, D.H., Richman, S., Riesen, R., Riles, K., Rizzi, A., Robertson, D.I., Robertson, N.A., Robison, L., Roddy, S., Rollins, J., Romano, J.D., Romie, J., Rong, H., Rose, D., Rotthoff, E., Rowan, S., Rüdiger, A., Russell, P., Ryan, K., Salzman, I., Sanders, G.H., Sannibale, V., Sathyaprakash, B., Saulson, P.R., Savage, R., Sazonov, A., Schilling, R., Schlaufman, K., Schmidt, V., Schofield, R., Schrempel, M., Schutz, B.F., Schwinberg, P., Scott, S.M., Searle, A.C., Sears, B., Seel, S., Sengupta, A.S., Shapiro, C.A., Shawhan, P., Shoemaker, D.H., Shu, Q.Z., Sibley, A., Siemens, X., Sievers, L., Sigg, D., Sintes, A.M., Skeldon, K., Smith, J.R., Smith, M., Smith, M.R., Sneddon, P., Spero, R., Stapfer, G., Strain, K.A., Strom, D., Stuver, A., Summerscales, T., Sumner, M.C., Sutton, P.J., Sylvestre, J., Takamori, A., Tanner, D.B., Tariq, H., Taylor, I., Taylor, R., Thorne, K.S., Tibbits, M., Tilav, S., Tinto, M., Tokmakov, K.V., Torres, C., Torrie, C., Traeger, S., Traylor, G., Tyler, W., Ugolini, D., Vallisneri, M., van Putten, M., Vass, S., Vecchio, A., Vorvick, C., Vyatchanin, S.P., Wallace, L., Walther, H., Ward, H., Ware, B., Watts, K., Webber, D., Weidner, A., Weiland, U., Weinstein, A., Weiss, R., Welling, H., Wen, L., Wen, S., Whelan, J.T., Whitcomb, S.E., Whiting, B.F., Willems, P.A., Williams, P.R., Williams, R., Willke, B., Wilson, A., Winjum, B.J., Winkler, W., Wise, S., Wiseman, A.G., Woan, G., Wooley, R., Worden, J., Yakushin, I., Yamamoto, H., Yoshida, S., Zawischa, I., Zhang, L., Zotov, N., Zucker, M., and Zweizig, J.

Published
2004
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