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145 results on '"D'Amora, Marta"'

5. Integrated opto-fluidic device for high-power living cell exposure and detection

Author

Everhardt, Arnoud S., primary, Konstantinidis, Vasileios, additional, Kapteijn, Paul, additional, Hoekman, Marcel, additional, Konstantinidou, Soultana, additional, D'Amora, Marta, additional, De Carli, Alessandro, additional, Fuso, Francesco, additional, Tantussi, Francesco, additional, Lai, Michele, additional, Raffa, Vittoria, additional, Al-Obaidi, Sadoon M. S., additional, Schilder, Noor A., additional, Heideman, René G., additional, Geuzebroek, Douwe H., additional, and Schreuder, Frederik, additional

Published
2024
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6. Interferometric Biosensor for High Sensitive Label-Free Recording of HiPS Cardiomyocytes Contraction in Vitro

Author

Boschi, Alessio, Iachetta, Giuseppina, Buonocore, Salvatore, Hubarevich, Aliaksandr, Hurtaud, Julien, Moreddu, Rosalia, d’Amora, Marta, Formoso, Maria Blanco, Tantussi, Francesco, Dipalo, Michele, and De Angelis, Francesco

Abstract

Heart disease remains a leading cause of global mortality, underscoring the need for advanced technologies to study cardiovascular diseases and develop effective treatments. We introduce an innovative interferometric biosensor for high-sensitivity and label-free recording of human induced pluripotent stem cell (hiPSC) cardiomyocyte contraction in vitro. Using an optical cavity, our device captures interference patterns caused by the contraction-induced displacement of a thin flexible membrane. First, we demonstrate the capability to quantify spontaneous contractions and discriminate between contraction and relaxation phases. We calculate a contraction-induced vertical membrane displacement close to 40 nm, which implies a traction stress of 34 ± 4 mN/mm2. Finally, we investigate the effects of a drug compound on contractility amplitude, revealing a significant reduction in contractile forces. The label-free and high-throughput nature of our biosensor may enhance drug screening processes and drug development for cardiac treatments. Our interferometric biosensor offers a novel approach for noninvasive and real-time assessment of cardiomyocyte contraction.

Published
2024
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9. Hyperbolic metamaterial nanoparticles random array for thermoplasmonics in the II and III near-infrared windows

Author

Zhao, Yingqi, Iarossi, Marzia, Maccaferri, Nicolò, Deleye, Lieselot, Melle, Giovanni, Huang, Jian-An, Iachetta, Giuseppina, D'Amora, Marta, Tantussi, Francesco, Isoniemi, Tommi, De Angelis, Francesco, Zhao, Yingqi, Iarossi, Marzia, Maccaferri, Nicolò, Deleye, Lieselot, Melle, Giovanni, Huang, Jian-An, Iachetta, Giuseppina, D'Amora, Marta, Tantussi, Francesco, Isoniemi, Tommi, and De Angelis, Francesco

Abstract

Plasmonic nanostructures capable of converting light to heat have found wide applications, thus giving rise to the field of thermoplasmonics. Among them, the use of gold-based plasmonic structures in near-infrared (NIR) spectral regions has catalyzed substantial research efforts due to the potential impact in clinical therapy applications. However, the photon scattering effect scaling with the square of the nanoparticle volume leads to high scattering and then low absorption efficiency. This limit has hindered the exploitation of gold nanoparticles, especially in NIR II regions above 1000 nm. Here, we make a step forward for overcoming this limitation by introducing hyperbolic metamaterial nanoparticles that are made of multi-layered gold/dielectric nanodisks and exhibit >70% absorption efficiency in the NIR II and III regions. Their high light-to-heat conversion is demonstrated by a much larger temperature increase than that of gold nanodisks with the same amount of gold. Efficient in vitro hyperthermia of living cells with negligible cytotoxicity shows the potential of our platform for versatile bio-medical applications.

Published
2023
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10. Integrated opto-fluidic device for high-power living cell exposure and detection

Author

Gray, Bonnie L., Rapp, Bastian E., Dalton, Colin, Everhardt, Arnoud S., Konstantinidis, Vasileios, Kapteijn, Paul, Hoekman, Marcel, Konstantinidou, Soultana, D'Amora, Marta, De Carli, Alessandro, Fuso, Francesco, Tantussi, Francesco, Lai, Michele, Raffa, Vittoria, Al-Obaidi, Sadoon, Schilder, Noor, Heideman, René, Geuzebroek, Douwe, and Schreuder, Frederik

Published
2024
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12. Contributors

Author

Albertazzi, Lorenzo, primary, Ancona, Andrea, additional, Arai, Satoshi, additional, Battaglini, Matteo, additional, Bayer, Ilker S., additional, Brachi, Giulia, additional, Burns, Austin, additional, Canavese, Giancarlo, additional, Canta, Marta, additional, Cao, Yiqi, additional, Capeletti, Larissa B., additional, Cardoso, Mateus B., additional, Cauda, Valentina, additional, Ciardelli, Gianluca, additional, Ciofani, Gianni, additional, d’Amora, Marta, additional, da Silva Liberato, Michelle, additional, Delcanale, Pietro, additional, Desai, Tejal A., additional, Diaconeasa, Zoriţa, additional, Dumontel, Bianca, additional, Feiner-Gracia, Natalia, additional, Garino, Nadia, additional, Genchi, Giada G., additional, Giordani, Silvia, additional, Laurenti, Marco, additional, Li, Tianshu, additional, Limongi, Tania, additional, Loiola, Lívia M.D., additional, Marino, Attilio, additional, Mattu, Clara, additional, Mele, Elisa, additional, Ménard-Moyon, Cécilia, additional, Pezzini, Ilaria, additional, Picco, Agustin S., additional, Pintea, Adela, additional, Pujals, Sílvia, additional, Racca, Luisa, additional, Rugină, Dumitriţa, additional, Self, William T., additional, Suzuki, Madoka, additional, Takeoka, Shinji, additional, and Tapeinos, Christos, additional

Published
2018
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14. Hyperbolic metamaterial nanoparticles random array for thermoplasmonics in the II and III near-infrared windows

Author

Zhao, Yingqi, primary, Iarossi, Marzia, additional, Maccaferri, Nicolò, additional, Deleye, Lieselot, additional, Melle, Giovanni, additional, Huang, Jian-An, additional, Iachetta, Giuseppina, additional, D'Amora, Marta, additional, Tantussi, Francesco, additional, Isoniemi, Tommi, additional, and De Angelis, Francesco, additional

Published
2023
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16. Zebrafish as an Innovative Tool for Epilepsy Modeling: State of the Art and Potential Future Directions.

Author

D'Amora, Marta, Galgani, Alessandro, Marchese, Maria, Tantussi, Francesco, Faraguna, Ugo, De Angelis, Francesco, and Giorgi, Filippo Sean

Subjects
*BRACHYDANIO, *EPILEPSY, *KAINIC acid, *ZEBRA danio, *NEUROLOGICAL disorders, *BRAIN anatomy
Abstract

This article discusses the potential of Zebrafish (ZF) (Danio Rerio), as a model for epilepsy research. Epilepsy is a neurological disorder affecting both children and adults, and many aspects of this disease are still poorly understood. In vivo and in vitro models derived from rodents are the most widely used for studying both epilepsy pathophysiology and novel drug treatments. However, researchers have recently obtained several valuable insights into these two fields of investigation by studying ZF. Despite the relatively simple brain structure of these animals, researchers can collect large amounts of data in a much shorter period and at lower costs compared to classical rodent models. This is particularly useful when a large number of candidate antiseizure drugs need to be screened, and ethical issues are minimized. In ZF, seizures have been induced through a variety of chemoconvulsants, primarily pentylenetetrazol (PTZ), kainic acid (KA), and pilocarpine. Furthermore, ZF can be easily genetically modified to test specific aspects of monogenic forms of human epilepsy, as well as to discover potential convulsive phenotypes in monogenic mutants. The article reports on the state-of-the-art and potential new fields of application of ZF research, including its potential role in revealing epileptogenic mechanisms, rather than merely assessing iatrogenic acute seizure modulation. [ABSTRACT FROM AUTHOR]

Published
2023
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18. A nanogenetic approach to genome editing

Author

Raffa, Vittoria, primary, Konstantinidou, Soultana, additional, Landi, Elena, additional, Nocilla, Francesco, additional, De Carli, Alessandro, additional, Witt, Dariusz, additional, Lindstaedt, Agnieszka, additional, D'Amora, Marta, additional, Lai, Michele, additional, Schmidt, Tiziana, additional, Pistello, Mauro, additional, Dente, Luciana, additional, Everhardt, Arnoud, additional, Tantussi, Francesco, additional, Fuso, Francesco, additional, Gabellini, Chiara, additional, Barski, Piotr, additional, and Freer, Giulia, additional

Published
2022
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19. Effects of Metal Oxide Nanoparticles in Zebrafish

Author

d’Amora, Marta, Schmidt, Tiziana Julia Nadjeschda, Konstantinidou, Soultana, Raffa, Vittoria, De Angelis, Francesco, and Tantussi, Francesco

Subjects
Article Subject
Abstract

Metal oxide nanoparticles (MO NPs) are increasingly employed in many fields with a wide range of applications from industries to drug delivery. Due to their semiconducting properties, metal oxide nanoparticles are commonly used in the manufacturing of several commercial products available in the market, including cosmetics, food additives, textile, paint, and antibacterial ointments. The use of metallic oxide nanoparticles for medical and cosmetic purposes leads to unavoidable human exposure, requiring a proper knowledge of their potentially harmful effects. This review offers a comprehensive overview of the possible toxicity of metallic oxide nanoparticles in zebrafish during both adulthood and growth stages, with an emphasis on the role of oxidative stress.

Published
2022
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23. In vitro and in vivo biocompatibility of boron/nitrogen co-doped carbon nano-onions

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Gobierno de Aragón, d’Amora, Marta, Camisasca, Adalberto, Arenal, Raúl, Giordani, Silvia, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Gobierno de Aragón, d’Amora, Marta, Camisasca, Adalberto, Arenal, Raúl, and Giordani, Silvia

Abstract

Boron/nitrogen, co-doped, carbon nano-onions (BN-CNOs) have recently shown great promise as catalysts for the oxygen reduction reaction, due to the improved electronic properties imparted by the dopant atoms; however, the interactions of BN-CNOs with biological systems have not yet been explored. In this study, we examined the toxicological profiles of BN-CNOs and oxidized BN-CNOs (oxi-BN-CNOs) in vitro in both healthy and cancer cell lines, as well as on the embryonic stages of zebrafish (Danio rerio) in vivo. The cell viabilities of both cell lines cells were not affected after treatment with different concentrations of both doped CNO derivatives. On the other hand, the analysis of BN-CNOs and oxidized BN-CNO interactions with zebrafish embryos did not report any kind of perturbations, in agreement with the in vitro results. Our results show that both doped CNO derivatives possess a high biocompatibility and biosafety in cells and more complex systems.

Published
2021

36. Fluorescent single-digit detonation nanodiamond for biomedical applications

Author

Nunn, Nicholas, primary, d’Amora, Marta, additional, Prabhakar, Neeraj, additional, Panich, Alexander M, additional, Froumin, Natalya, additional, Torelli, Marco D, additional, Vlasov, Igor, additional, Reineck, Philipp, additional, Gibson, Brant, additional, Rosenholm, Jessica M, additional, Giordani, Silvia, additional, and Shenderova, Olga, additional

Published
2018
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49. Biodistribution and biocompatibility of passion fruit-like nano-architectures in zebrafish.

Author

d'Amora, Marta, Cassano, Domenico, Pocoví-Martínez, Salvador, Giordani, Silvia, and Voliani, Valerio

Subjects
*ZEBRA danio, *NANOTECHNOLOGY, *NANOPARTICLES, *NANOMEDICINE, *BIOCOMPATIBILITY
Abstract

Passion fruit-like nano-architectures (NAs) are all-in-one platforms of increasing interest for the translation of metal nanoparticles into clinics. NAs are nature-inspired disassembling inorganic theranostics, which jointly combine most of the appealing behaviors of noble metal nanoparticles with their potential organism excretion. Despite their unique and promising properties, NAs in vivo interactions and potential adverse effects have not yet been investigated. In this study, we employ zebrafish (Danio Rerio) to assess the development toxicity of NAs as well as their uptake and bioaccumulation at different stages of growth. The evaluation of multiple endpoints related to the toxicity clearly indicates that NAs do not induce mortality, developmental defects, or alterations on the hatching rate and behavior of zebrafish. Moreover, the analysis of nanostructures uptake and biodistribution demonstrates that NAs are successfully internalized and present a specific localization. Overall, our results demonstrate that NAs are able to pass through the embryos chorion and accumulate in specific tissues, exhibiting an impressive biocompatibility. [ABSTRACT FROM AUTHOR]

Published
2018
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