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194 results on '"D'Angelo, Fulvio"'

1. Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm

Author

Wang, Lujia, Wang, Hairong, D'Angelo, Fulvio, Curtin, Lee, Sereduk, Christopher P., De Leon, Gustavo, Singleton, Kyle W., Urcuyo, Javier, Hawkins-Daarud, Andrea, Jackson, Pamela R., Krishna, Chandan, Zimmerman, Richard S., Patra, Devi P., Bendok, Bernard R., Smith, Kris A., Nakaji, Peter, Donev, Kliment, Baxter, Leslie C., Mrugała, Maciej M., Ceccarelli, Michele, Iavarone, Antonio, Swanson, Kristin R., Tran, Nhan L., Hu, Leland S., and Li, Jing

Subjects
Computer Science - Machine Learning, Computer Science - Computer Vision and Pattern Recognition, Mathematics - Optimization and Control
Abstract

Glioblastoma (GBM) is one of the most aggressive and lethal human cancers. Intra-tumoral genetic heterogeneity poses a significant challenge for treatment. Biopsy is invasive, which motivates the development of non-invasive, MRI-based machine learning (ML) models to quantify intra-tumoral genetic heterogeneity for each patient. This capability holds great promise for enabling better therapeutic selection to improve patient outcomes. We proposed a novel Weakly Supervised Ordinal Support Vector Machine (WSO-SVM) to predict regional genetic alteration status within each GBM tumor using MRI. WSO-SVM was applied to a unique dataset of 318 image-localized biopsies with spatially matched multiparametric MRI from 74 GBM patients. The model was trained to predict the regional genetic alteration of three GBM driver genes (EGFR, PDGFRA, and PTEN) based on features extracted from the corresponding region of five MRI contrast images. For comparison, a variety of existing ML algorithms were also applied. The classification accuracy of each gene was compared between the different algorithms. The SHapley Additive exPlanations (SHAP) method was further applied to compute contribution scores of different contrast images. Finally, the trained WSO-SVM was used to generate prediction maps within the tumoral area of each patient to help visualize the intra-tumoral genetic heterogeneity. This study demonstrated the feasibility of using MRI and WSO-SVM to enable non-invasive prediction of intra-tumoral regional genetic alteration for each GBM patient, which can inform future adaptive therapies for individualized oncology., Comment: 36 pages, 8 figures, 3 tables

Published
2023

2. Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures

Author

Hu, Leland S., D’Angelo, Fulvio, Weiskittel, Taylor M., Caruso, Francesca P., Fortin Ensign, Shannon P., Blomquist, Mylan R., Flick, Matthew J., Wang, Lujia, Sereduk, Christopher P., Meng-Lin, Kevin, De Leon, Gustavo, Nespodzany, Ashley, Urcuyo, Javier C., Gonzales, Ashlyn C, Curtin, Lee, Lewis, Erika M., Singleton, Kyle W., Dondlinger, Timothy, Anil, Aliya, Semmineh, Natenael B., Noviello, Teresa, Patel, Reyna A., Wang, Panwen, Wang, Junwen, Eschbacher, Jennifer M., Hawkins-Daarud, Andrea, Jackson, Pamela R., Grunfeld, Itamar S., Elrod, Christian, Mazza, Gina L., McGee, Sam C., Paulson, Lisa, Clark-Swanson, Kamala, Lassiter-Morris, Yvette, Smith, Kris A., Nakaji, Peter, Bendok, Bernard R., Zimmerman, Richard S., Krishna, Chandan, Patra, Devi P., Patel, Naresh P., Lyons, Mark, Neal, Matthew, Donev, Kliment, Mrugala, Maciej M., Porter, Alyx B., Beeman, Scott C., Jensen, Todd R., Schmainda, Kathleen M., Zhou, Yuxiang, Baxter, Leslie C., Plaisier, Christopher L., Li, Jing, Li, Hu, Lasorella, Anna, Quarles, C. Chad, Swanson, Kristin R., Ceccarelli, Michele, Iavarone, Antonio, and Tran, Nhan L.

Published
2023
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3. Glioma progression is shaped by genetic evolution and microenvironment interactions

Author

Varn, Frederick S, Johnson, Kevin C, Martinek, Jan, Huse, Jason T, Nasrallah, MacLean P, Wesseling, Pieter, Cooper, Lee AD, Malta, Tathiane M, Wade, Taylor E, Sabedot, Thais S, Brat, Daniel, Gould, Peter V, Wöehrer, Adelheid, Aldape, Kenneth, Ismail, Azzam, Sivajothi, Santhosh K, Barthel, Floris P, Kim, Hoon, Kocakavuk, Emre, Ahmed, Nazia, White, Kieron, Datta, Indrani, Moon, Hyo-Eun, Pollock, Steven, Goldfarb, Christine, Lee, Ga-Hyun, Garofano, Luciano, Anderson, Kevin J, Nehar-Belaid, Djamel, Barnholtz-Sloan, Jill S, Bakas, Spyridon, Byrne, Annette T, D’Angelo, Fulvio, Gan, Hui K, Khasraw, Mustafa, Migliozzi, Simona, Ormond, D Ryan, Paek, Sun Ha, Van Meir, Erwin G, Walenkamp, Annemiek ME, Watts, Colin, Weiss, Tobias, Weller, Michael, Palucka, Karolina, Stead, Lucy F, Poisson, Laila M, Noushmehr, Houtan, Iavarone, Antonio, Verhaak, Roel GW, Consortium, The GLASS, Alfaro, Kristin D, Amin, Samirkumar B, Ashley, David M, Bock, Christoph, Brodbelt, Andrew, Bulsara, Ketan R, and Castro, Ana Valeria

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Brain Disorders, Brain Cancer, Genetics, Cancer, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Adult, Brain Neoplasms, Evolution, Molecular, Genes, p16, Glioma, Humans, Isocitrate Dehydrogenase, Mutation, Neoplasm Recurrence, Local, Tumor Microenvironment, GLASS Consortium, genomics, glioblastoma, glioma, hypermutation, macrophages, microenvironment, neurons, single-cell, spatial imaging, treatment resistance, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histological feature composition, somatic alterations, and microenvironment interactions. Hypermutation and acquired CDKN2A deletions were associated with an increase in proliferating neoplastic cells at recurrence in both glioma subtypes, reflecting active tumor growth. IDH-wild-type tumors were more invasive at recurrence, and their neoplastic cells exhibited increased expression of neuronal signaling programs that reflected a possible role for neuronal interactions in promoting glioma progression. Mesenchymal transition was associated with the presence of a myeloid cell state defined by specific ligand-receptor interactions with neoplastic cells. Collectively, these recurrence-associated phenotypes represent potential targets to alter disease progression.

Published
2022

4. Integrated proteogenomic characterization of glioblastoma evolution

Author

Kim, Kyung-Hee, Migliozzi, Simona, Koo, Harim, Hong, Jun-Hee, Park, Seung Min, Kim, Sooheon, Kwon, Hyung Joon, Ha, Seokjun, Garofano, Luciano, Oh, Young Taek, D'Angelo, Fulvio, Kim, Chan Il, Kim, Seongsoo, Lee, Ji Yoon, Kim, Jiwon, Hong, Jisoo, Jang, Eun-Hae, Mathon, Bertrand, Di Stefano, Anna-Luisa, Bielle, Franck, Laurenge, Alice, Nesvizhskii, Alexey I., Hur, Eun-Mi, Yin, Jinlong, Shi, Bingyang, Kim, Youngwook, Moon, Kyung-Sub, Kwon, Jeong Taik, Lee, Shin Heon, Lee, Seung Hoon, Gwak, Ho Shin, Lasorella, Anna, Yoo, Heon, Sanson, Marc, Sa, Jason K., Park, Chul-Kee, Nam, Do-Hyun, Iavarone, Antonio, and Park, Jong Bae

Published
2024
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6. Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression

Author

Blomquist, Mylan R, Ensign, Shannon Fortin, D’Angelo, Fulvio, Phillips, Joanna J, Ceccarelli, Michele, Peng, Sen, Halperin, Rebecca F, Caruso, Francesca P, Garofano, Luciano, Byron, Sara A, Liang, Winnie S, Craig, David W, Carpten, John D, Prados, Michael D, Trent, Jeffrey M, Berens, Michael E, Iavarone, Antonio, Dhruv, Harshil, and Tran, Nhan L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Brain Cancer, Rare Diseases, Genetics, Human Genome, Cancer, Neurosciences, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, clonal evolution, contrast enhancement, glioblastoma, PI3K signaling, temporospatial heterogeneity
Abstract

BackgroundTumor heterogeneity underlies resistance and disease progression in glioblastoma (GBM), and tumors most commonly recur adjacent to the surgical resection margins in contrast non-enhancing (NE) regions. To date, no targeted therapies have meaningfully altered overall patient survival in the up-front setting. The aim of this study was to characterize intratumoral heterogeneity in recurrent GBM using bulk samples from primary resection and recurrent samples taken from contrast-enhancing (EN) and contrast NE regions.MethodsWhole exome and RNA sequencing were performed on matched bulk primary and multiple recurrent EN and NE tumor samples from 16 GBM patients who received standard of care treatment alone or in combination with investigational clinical trial regimens.ResultsPrivate mutations emerge across multi-region sampling in recurrent tumors. Genomic clonal analysis revealed increased enrichment in gene alterations regulating the G2M checkpoint, Kras signaling, Wnt signaling, and DNA repair in recurrent disease. Subsequent functional studies identified augmented PI3K/AKT transcriptional and protein activity throughout progression, validated by phospho-protein levels. Moreover, a mesenchymal transcriptional signature was observed in recurrent EN regions, which differed from the proneural signature in recurrent NE regions.ConclusionsSubclonal populations observed within bulk resected primary GBMs transcriptionally evolve across tumor recurrence (EN and NE regions) and exhibit aberrant gene expression of common signaling pathways that persist despite standard or targeted therapy. Our findings provide evidence that there are both adaptive and clonally mediated dependencies of GBM on key pathways, such as the PI3K/AKT axis, for survival across recurrences.

Published
2020

8. Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm

Author

Wang, Lujia, primary, Wang, Hairong, additional, D’Angelo, Fulvio, additional, Curtin, Lee, additional, Sereduk, Christopher P., additional, Leon, Gustavo De, additional, Singleton, Kyle W., additional, Urcuyo, Javier, additional, Hawkins-Daarud, Andrea, additional, Jackson, Pamela R., additional, Krishna, Chandan, additional, Zimmerman, Richard S., additional, Patra, Devi P., additional, Bendok, Bernard R., additional, Smith, Kris A., additional, Nakaji, Peter, additional, Donev, Kliment, additional, Baxter, Leslie C., additional, Mrugała, Maciej M., additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, Swanson, Kristin R., additional, Tran, Nhan L., additional, Hu, Leland S., additional, and Li, Jing, additional

Published
2024
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9. Table S1 from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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10. Supp Figures from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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11. Supplemental Figures Legends from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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12. Data from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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13. Supplementary Appendix from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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15. First access to mental health services during COVID-19 pandemic: A multicenter study

Author

Eleonora Petri, Cristina Nardoni, Erika Fui, Elisa Gulino, Lachheb Abdelghani, Raffaele Barone, Paolo Angelo Fulvio Miragoli, Giuseppe Cardamone, and Agnese Ciberti

Subjects
Depression, Anxiety, post-traumatic, COVID-19, Pandemic, Mental health services, Mental healing, RZ400-408
Abstract

Background: The impact of the COVID-19 pandemic on mental health is complex and affects a broad segment of the population. Several studies indicate that depressive, anxious and post-traumatic symptoms are common in people exposed to SARS-Cov2.Methods: 458 subjects were recruited during their first consultation in outpatient psychiatric services between June 2020 and October 2021. Post-traumatic, depressive and anxious symptoms were assessed using the Impact of Event Scale-Revised (IES-R), the Beck Depression Inventory Scale-second edition (BDI-II), and the Self Rating Anxiety Scale (SAS). A specific set of questions was developed, with the aim of evaluating socio-demographic variables and work, environmental and personal characteristics related to the pandemic.Results: Prevalence rates of clinically significant depressive, anxious and post-traumatic symptoms were 57.6%, 63.5% and 54.8%, respectively. Female gender, worsening of relationship status and financial consequences due to the pandemic were the conditions most strongly associated with the presence of psychopathology.Limitation: The cross-sectional design of the study doesn't allow an evaluation over time of the sample. No assumption of causality can be made due to the lack of pre-pandemic assessments for the investigated variables.Conclusions: The impact of the pandemic involves depressive, anxious and post-traumatic dimensions. The investigated psychopathology correlates with several variables expressing the personal and environmental changes that occurred in the population due to the COVID-19 emergency. The study is multicentric and the recruitment of participants was held in a clinical setting, providing a realistic picture of the consequences of the pandemic in clinical practice within mental health services.

Published
2023
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16. The epigenetic evolution of glioma is determined by the IDH1 mutation status and treatment regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., additional, Morosini, Natalia S., additional, Datta, Indrani, additional, Garofano, Luciano, additional, Vallentgoed, Wies R., additional, Varn, Frederick S., additional, Aldape, Kenneth, additional, D'Angelo, Fulvio, additional, Bakas, Spyridon, additional, Barnholtz-Sloan, Jill S., additional, Gan, Hui K., additional, Hasanain, Mohammad, additional, Hau, Ann-Christin, additional, Johnson, Kevin C., additional, Cazacu, Simona, additional, deCarvalho, Ana C., additional, Khasraw, Mustafa, additional, Kocakavuk, Emre, additional, Kouwenhoven, Mathilde C.M., additional, Migliozzi, Simona, additional, Niclou, Simone P., additional, Niers, Johanna M., additional, Ormond, D. Ryan., additional, Paek, Sun Ha, additional, Reifenberger, Guido, additional, Sillevis Smitt, Peter A., additional, Smits, Marion, additional, Stead, Lucy F., additional, van den Bent, Martin J., additional, Van Meir, Erwin G., additional, Walenkamp, Annemiek, additional, Weiss, Tobias, additional, Weller, Michael, additional, Westerman, Bart A., additional, Ylstra, Bauke, additional, Wesseling, Pieter, additional, Lasorella, Anna, additional, French, Pim J., additional, Poisson, Laila M., additional, Consortium, The GLASS, additional, Verhaak, Roel G.W., additional, Iavarone, Antonio, additional, and Noushmehr, Houtan, additional

Published
2023
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18. EPCO-27. RECONSTRUCTION OF THE SPATIAL ECOSYSTEM OF GLIOBLASTOMA REVEALS RECURRENT RELATIONSHIPS BETWEEN TUMOR CELL STATES AND TUMOR MICROENVIRONMENT

Author

Adabbo, Bruno, primary, Migliozzi, Simona, additional, Garofano, Luciano, additional, Oh, Young Taek, additional, Gultekin, Sakir H, additional, D'Angelo, Fulvio, additional, Roberts, Evan R, additional, Bilbao, Daniel C, additional, Davila, Pedro M, additional, Williams, Sion L, additional, Currall, Benjamin B, additional, Ceccarelli, Michele, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2023
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19. EPCO-37. DISSECTING GBM EVOLUTION FOLLOWING STANDARD-OF-CARE BY LARGE-SCALE LONGITUDINAL SINGLE NUCLEUS RNA-SEQUENCING

Author

Nomura, Masashi, primary, Spitzer, Avishay, additional, Johnson, Kevin, additional, Garofano, Luciano, additional, Nehar-Belaid, Djamel, additional, Oh, Young Taek, additional, Anderson, Kevin J, additional, Najac, Ryan D, additional, Bussema, Lillian, additional, Varn, Frederick, additional, D’Angelo, Fulvio, additional, Chowdhury, Tamrin, additional, Migliozzi, Simona, additional, Park, Jong Bae, additional, Ermini, Luca, additional, Golebiewska, Anna, additional, Niclou, Simone, additional, Das, Sunit, additional, Paek, Sun Ha, additional, Moon, Hyo-Eun, additional, Mathon, Bertrand, additional, Stefano, Anna-Luisa Di, additional, Bielle, Franck, additional, Laurenge, Alice, additional, Sanson, Marc, additional, Tanaka, Shota, additional, Saito, Nobuhito, additional, Keir, Steve, additional, Ashley, David, additional, Huse, Jason, additional, Alfred Yung, W K, additional, Lasorella, Anna, additional, Iavarone, Antonio, additional, Verhaak, Roel, additional, Suva, Mario, additional, and Tirosh, Itay, additional

Published
2023
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20. EPCO-09. CHARACTERIZING THE GBM CELLULAR LANDSCAPE BY LARGE-SCALE SINGLE-NUCLEUS RNA-SEQUENCING

Author

Spitzer, Avishay, primary, Nomura, Masashi, additional, Garofano, Luciano, additional, Johnson, Kevin, additional, Nehar-Belaid, Djamel, additional, Oh, Young Taek, additional, Anderson, Kevin J, additional, Najac, Ryan D, additional, Bussema, Lillian, additional, Varn, Frederick, additional, D’Angelo, Fulvio, additional, Chowdhury, Tamrin, additional, Migliozzi, Simona, additional, Park, Jong Bae, additional, Ermini, Luca, additional, Golebiewska, Anna, additional, Niclou, Simone, additional, Das, Sunit, additional, Paek, Sun Ha, additional, Moon, Hyo-Eun, additional, Mathon, Bertrand, additional, Stefano, Anna-Luisa Di, additional, Bielle, Franck, additional, Laurenge, Alice, additional, Sanson, Marc, additional, Tanaka, Shota, additional, Saito, Nobuhito, additional, Keir, Steve, additional, Ashley, David, additional, Huse, Jason, additional, Yung, W K Alfred, additional, Lasorella, Anna, additional, Verhaak, Roel, additional, Iavarone, Antonio, additional, Tirosh, Itay, additional, and Suva, Mario, additional

Published
2023
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21. Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities

Author

Garofano, Luciano, Migliozzi, Simona, Oh, Young Taek, D’Angelo, Fulvio, Najac, Ryan D., Ko, Aram, Frangaj, Brulinda, Caruso, Francesca Pia, Yu, Kai, Yuan, Jinzhou, Zhao, Wenting, Di Stefano, Anna Luisa, Bielle, Franck, Jiang, Tao, Sims, Peter, Suvà, Mario L., Tang, Fuchou, Su, Xiao-Dong, Ceccarelli, Michele, Sanson, Marc, Lasorella, Anna, and Iavarone, Antonio

Published
2021
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22. Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

Author

Ceccarelli, Michele, Barthel, Floris P, Malta, Tathiane M, Sabedot, Thais S, Salama, Sofie R, Murray, Bradley A, Morozova, Olena, Newton, Yulia, Radenbaugh, Amie, Pagnotta, Stefano M, Anjum, Samreen, Wang, Jiguang, Manyam, Ganiraju, Zoppoli, Pietro, Ling, Shiyun, Rao, Arjun A, Grifford, Mia, Cherniack, Andrew D, Zhang, Hailei, Poisson, Laila, Carlotti, Carlos Gilberto, da Cunha Tirapelli, Daniela Pretti, Rao, Arvind, Mikkelsen, Tom, Lau, Ching C, Yung, WK Alfred, Rabadan, Raul, Huse, Jason, Brat, Daniel J, Lehman, Norman L, Barnholtz-Sloan, Jill S, Zheng, Siyuan, Hess, Kenneth, Rao, Ganesh, Meyerson, Matthew, Beroukhim, Rameen, Cooper, Lee, Akbani, Rehan, Wrensch, Margaret, Haussler, David, Aldape, Kenneth D, Laird, Peter W, Gutmann, David H, Network, TCGA Research, Arachchi, Harindra, Auman, J Todd, Balasundaram, Miruna, Balu, Saianand, Barnett, Gene, Baylin, Stephen, Bell, Sue, Benz, Christopher, Bir, Natalie, Black, Keith L, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S, Bowen, Jay, Bristow, Christopher A, Butterfield, Yaron SN, Chen, Qing-Rong, Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Coetzee, Simon G, Cohen, Mark L, Colman, Howard, Couce, Marta, D’Angelo, Fulvio, Davidsen, Tanja, Davis, Amy, Demchok, John A, Devine, Karen, Ding, Li, Duell, Rebecca, Elder, J Bradley, Eschbacher, Jennifer M, Fehrenbach, Ashley, Ferguson, Martin, Frazer, Scott, Fuller, Gregory, Fulop, Jordonna, Gabriel, Stacey B, Garofano, Luciano, Gastier-Foster, Julie M, Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Giannini, Caterina, Gibson, William J, Hadjipanayis, Angela, Hayes, D Neil, Heiman, David I, Hermes, Beth, Hilty, Joe, Hoadley, Katherine A, Hoyle, Alan P, and Huang, Mei

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Bioinformatics and Computational Biology, Genetics, Oncology and Carcinogenesis, Orphan Drug, Brain Cancer, Brain Disorders, Biotechnology, Human Genome, Rare Diseases, Neurosciences, Cancer, Adult, Brain Neoplasms, Cell Proliferation, Cluster Analysis, DNA Helicases, DNA Methylation, Epigenesis, Genetic, Glioma, Humans, Isocitrate Dehydrogenase, Middle Aged, Mutation, Nuclear Proteins, Promoter Regions, Genetic, Signal Transduction, Telomerase, Telomere, Transcriptome, X-linked Nuclear Protein, TCGA Research Network, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease. Whole-genome sequencing data analysis determined that ATRX but not TERT promoter mutations are associated with increased telomere length. Recent advances in glioma classification based on IDH mutation and 1p/19q co-deletion status were recapitulated through analysis of DNA methylation profiles, which identified clinically relevant molecular subsets. A subtype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-type diffuse glioma showed molecular similarity to pilocytic astrocytoma and relatively favorable survival. Understanding of cohesive disease groups may aid improved clinical outcomes.

Published
2016

23. The molecular landscape of glioma in patients with Neurofibromatosis 1

Author

D’Angelo, Fulvio, Ceccarelli, Michele, Tala, Garofano, Luciano, Zhang, Jing, Frattini, Véronique, Caruso, Francesca P., Lewis, Genevieve, Alfaro, Kristin D., Bauchet, Luc, Berzero, Giulia, Cachia, David, Cangiano, Mario, Capelle, Laurent, de Groot, John, DiMeco, Francesco, Ducray, François, Farah, Walid, Finocchiaro, Gaetano, Goutagny, Stéphane, Kamiya-Matsuoka, Carlos, Lavarino, Cinzia, Loiseau, Hugues, Lorgis, Véronique, Marras, Carlo E., McCutcheon, Ian, Nam, Do-Hyun, Ronchi, Susanna, Saletti, Veronica, Seizeur, Romuald, Slopis, John, Suñol, Mariona, Vandenbos, Fanny, Varlet, Pascale, Vidaud, Dominique, Watts, Colin, Tabar, Viviane, Reuss, David E., Kim, Seung-Ki, Meyronet, David, Mokhtari, Karima, Salvador, Hector, Bhat, Krishna P., Eoli, Marica, Sanson, Marc, Lasorella, Anna, and Iavarone, Antonio

Published
2019
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24. Supplementary Tables S1-S3 from LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL

Author

Ko, Aram, primary, Hasanain, Mohammad, primary, Oh, Young Taek, primary, D'Angelo, Fulvio, primary, Sommer, Danika, primary, Frangaj, Brulinda, primary, Tran, Suzanne, primary, Bielle, Franck, primary, Pollo, Bianca, primary, Paterra, Rosina, primary, Mokhtari, Karima, primary, Soni, Rajesh Kumar, primary, Peyre, Matthieu, primary, Eoli, Marica, primary, Papi, Laura, primary, Kalamarides, Michel, primary, Sanson, Marc, primary, Iavarone, Antonio, primary, and Lasorella, Anna, primary

Published
2023
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25. Supplementary Figure S1. from LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL

Author

Ko, Aram, primary, Hasanain, Mohammad, primary, Oh, Young Taek, primary, D'Angelo, Fulvio, primary, Sommer, Danika, primary, Frangaj, Brulinda, primary, Tran, Suzanne, primary, Bielle, Franck, primary, Pollo, Bianca, primary, Paterra, Rosina, primary, Mokhtari, Karima, primary, Soni, Rajesh Kumar, primary, Peyre, Matthieu, primary, Eoli, Marica, primary, Papi, Laura, primary, Kalamarides, Michel, primary, Sanson, Marc, primary, Iavarone, Antonio, primary, and Lasorella, Anna, primary

Published
2023
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26. Abstract 5621: Multi-parametric MRI maps regional heterogeneity of high grade glioma phenotypes

Author

Flick, Matthew, primary, Weiskittel, Taylor, additional, Meng-Lin, Kevin, additional, D'Angelo, Fulvio, additional, Caruso, Francesca, additional, Ensign, Shannon, additional, Blomquist, Mylan, additional, Wang, Luija, additional, Sereduk, Christopher, additional, De Leon, Gustavo, additional, Nespodzany, Ashley, additional, Urcuyo, Javier, additional, Gonzalez, Ashlynn, additional, Curtin, Lee, additional, Singleton, Kyle, additional, Anil, Aliya, additional, Simmineh, Natenael, additional, Lewis, Erika, additional, Noviello, Teresa, additional, Patel, Reyna, additional, Wang, Panwen, additional, Wang, Junwen, additional, Eschbacher, Jennifer, additional, Hawkins-Daarud, Andrea, additional, Jackson, Pamela, additional, Smith, Kris, additional, Nakaji, Peter, additional, Bendok, Bernard, additional, Zimmerman, Richard, additional, Krishna, Chandan, additional, Patra, Devi, additional, Patel, Naresh, additional, Lyons, Mark, additional, Neal, Matthew, additional, Donev, Kliment, additional, Mrugala, Maciej, additional, Porter, Alyx, additional, Beeman, Scott, additional, Zhou, Yuxiang, additional, Baxter, Leslie, additional, Plaisier, Christopher, additional, Li, Jing, additional, Li, Hu, additional, Lasorella, Anna, additional, Quarles, Chad, additional, Swanson, Kristin, additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, Tran, Nhan, additional, and Hu, Leland, additional

Published
2023
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27. Data from LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL

Author

Ko, Aram, primary, Hasanain, Mohammad, primary, Oh, Young Taek, primary, D'Angelo, Fulvio, primary, Sommer, Danika, primary, Frangaj, Brulinda, primary, Tran, Suzanne, primary, Bielle, Franck, primary, Pollo, Bianca, primary, Paterra, Rosina, primary, Mokhtari, Karima, primary, Soni, Rajesh Kumar, primary, Peyre, Matthieu, primary, Eoli, Marica, primary, Papi, Laura, primary, Kalamarides, Michel, primary, Sanson, Marc, primary, Iavarone, Antonio, primary, and Lasorella, Anna, primary

Published
2023
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28. Abstract 1507: Multiregional sampling of high grade glioma identifies regional biologic signatures

Author

Blomquist, Mylan R., primary, Hu, Leland S., additional, D'Angelo, Fulvio, additional, Weiskittel, Taylor M., additional, Caruso, Francesca P., additional, Ensign, Shannon P. Fortin, additional, Sereduk, Christopher, additional, De Leon, Gustavo, additional, Curtin, Lee, additional, Urcuyo, Javier, additional, Gonzalez, Ashlynn, additional, Nespodzany, Ashley, additional, Noviello, Teresa, additional, Eschbacher, Jennifer M., additional, Smith, Kris A., additional, Nakaji, Peter, additional, Bendok, Bernard R., additional, Zimmerman, Richard S., additional, Krishna, Chandan, additional, Patra, Devi, additional, Patel, Naresh, additional, Lyons, Mark, additional, Donev, Kliment, additional, Mrugala, Maciej, additional, Porter, Alyx, additional, Lasorella, Anna, additional, Swanson, Kristin R., additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, and Tran, Nhan L., additional

Published
2023
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29. Supplementary Figures 1-9 from Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, primary, Parcesepe, Pietro, primary, Ferrarini, Alberto, primary, Han, Hye Seung, primary, Mickys, Ugnius, primary, Laudanna, Carmelo, primary, Simbolo, Michele, primary, Malanga, Donatella, primary, Oliveira, Duarte Mendes, primary, Baritono, Elisabetta, primary, Colangelo, Tommaso, primary, Sabatino, Lina, primary, Giuliani, Jacopo, primary, Molinari, Enrico, primary, Garonzi, Marianna, primary, Xumerle, Luciano, primary, Delledonne, Massimo, primary, Giordano, Guido, primary, Ghimenton, Claudio, primary, Lonardo, Fortunato, primary, D'angelo, Fulvio, primary, Grillo, Federica, primary, Mastracci, Luca, primary, Viglietto, Giuseppe, primary, Ceccarelli, Michele, primary, Colantuoni, Vittorio, primary, Scarpa, Aldo, primary, and Pancione, Massimo, primary

Published
2023
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30. Supplementary Tables 1-9 from Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, primary, Parcesepe, Pietro, primary, Ferrarini, Alberto, primary, Han, Hye Seung, primary, Mickys, Ugnius, primary, Laudanna, Carmelo, primary, Simbolo, Michele, primary, Malanga, Donatella, primary, Oliveira, Duarte Mendes, primary, Baritono, Elisabetta, primary, Colangelo, Tommaso, primary, Sabatino, Lina, primary, Giuliani, Jacopo, primary, Molinari, Enrico, primary, Garonzi, Marianna, primary, Xumerle, Luciano, primary, Delledonne, Massimo, primary, Giordano, Guido, primary, Ghimenton, Claudio, primary, Lonardo, Fortunato, primary, D'angelo, Fulvio, primary, Grillo, Federica, primary, Mastracci, Luca, primary, Viglietto, Giuseppe, primary, Ceccarelli, Michele, primary, Colantuoni, Vittorio, primary, Scarpa, Aldo, primary, and Pancione, Massimo, primary

Published
2023
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31. Supplementary Materials and Methods from Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, primary, Parcesepe, Pietro, primary, Ferrarini, Alberto, primary, Han, Hye Seung, primary, Mickys, Ugnius, primary, Laudanna, Carmelo, primary, Simbolo, Michele, primary, Malanga, Donatella, primary, Oliveira, Duarte Mendes, primary, Baritono, Elisabetta, primary, Colangelo, Tommaso, primary, Sabatino, Lina, primary, Giuliani, Jacopo, primary, Molinari, Enrico, primary, Garonzi, Marianna, primary, Xumerle, Luciano, primary, Delledonne, Massimo, primary, Giordano, Guido, primary, Ghimenton, Claudio, primary, Lonardo, Fortunato, primary, D'angelo, Fulvio, primary, Grillo, Federica, primary, Mastracci, Luca, primary, Viglietto, Giuseppe, primary, Ceccarelli, Michele, primary, Colantuoni, Vittorio, primary, Scarpa, Aldo, primary, and Pancione, Massimo, primary

Published
2023
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32. LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL

Author

Ko, Aram, primary, Hasanain, Mohammad, additional, Oh, Young Taek, additional, D'Angelo, Fulvio, additional, Sommer, Danika, additional, Frangaj, Brulinda, additional, Tran, Suzanne, additional, Bielle, Franck, additional, Pollo, Bianca, additional, Paterra, Rosina, additional, Mokhtari, Karima, additional, Soni, Rajesh Kumar., additional, Peyre, Matthieu, additional, Eoli, Marica, additional, Papi, Laura, additional, Kalamarides, Michel, additional, Sanson, Marc, additional, Iavarone, Antonio, additional, and Lasorella, Anna, additional

Published
2022
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34. EPCO-03. PATHWAY-BASED STRATIFICATION OF GLIOBLASTOMA BY MULTI-OMICS INFORMS SUBTYPE-SPECIFIC MASTER KINASES-PHOSPHOSITE SUBSTRATES

Author

Migliozzi, Simona, primary, Oh, Young Taek, additional, Hasanain, Mohammad, additional, Garofano, Luciano, additional, D'Angelo, Fulvio, additional, Picca, Alberto, additional, Bielle, Franck, additional, Sarkaria, Jann, additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2022
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35. EXTH-21. DEVELOPMENT OF THERAPEUTIC STRATEGIES BY PATHWAY-BASED MULTI-OMICS APPROACH AND MASTER KINASE ANALYSIS IN GLIOBLASTOMA MULTIFORME

Author

Oh, Michael, primary, Hasanain, Mohammad, additional, Migliozzi, Simona, additional, Garofano, Luciano, additional, D'Angelo, Fulvio, additional, Stefano, Anna Luisa Di, additional, Lerond, Julie, additional, Sarkaria, Jann, additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2022
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37. CSIG-01. EGFR AND AXL RECEPTOR TYROSINE KINASES DRIVE ONCOGENESIS BY LZTR1 MUTATION

Author

Ko, Aram, primary, Hasanain, Mohammad, additional, Oh, Young Taek, additional, D'Angelo, Fulvio, additional, Sommer, Danika, additional, Frangaj, Brulinda, additional, Tran, Suzanne, additional, Bielle, Franck, additional, Pollo, Bianca, additional, Paterra, Rosina, additional, Mokhtari, Karima, additional, Soni, Rajesh, additional, Peyre, Matthieu, additional, Eoli, Marica, additional, Kalamarides, Michel, additional, Sanson, Marc, additional, Iavarone, Antonio, additional, and Lasorella, Anna, additional

Published
2022
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39. An Approach to Identify miRNA Associated with Cancer Altered Pathways

Author

Ventola, Giovanna Maria, Colaprico, Antonio, D’Angelo, Fulvio, Colantuoni, Vittorio, Viglietto, Giuseppe, Cerulo, Luigi, Ceccarelli, Michele, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Petrosino, Alfredo, editor, Maddalena, Lucia, editor, and Pala, Pietro, editor

Published
2013
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40. Abstract 4014: Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification

Author

Migliozzi, Simona, primary, Oh, Young Taek, additional, Garofano, Luciano, additional, Mohammad, Hasanain, additional, D'Angelo, Fulvio, additional, Najac, Ryan D., additional, Bielle, Franck, additional, Mokhtari, Karima, additional, Sarkaria, Jann N., additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2022
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41. Abstract 770: Multiregional imaging and genomic analysis in high-grade IDH-mutant astrocytoma identifies intratumor subclones with aggressive features

Author

Ensign, Shannon P. Fortin, primary, D'Angelo, Fulvio, additional, Caruso, Francesca P., additional, Sereduk, Christopher, additional, Singleton, Kyle, additional, Eschbacher, Jennifer, additional, Mazza, Gina, additional, Mrugala, Maciej, additional, Porter, Alyx, additional, Bendok, Bernard, additional, Zimmerman, Richard, additional, Smith, Kris, additional, Nakaji, Peter, additional, Swanson, Kamala, additional, Wang, Junwen, additional, Semmineh, Nathenael, additional, Quarles, Christopher, additional, Lasorella, Anna, additional, Swanson, Kristin, additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, Hu, Leland, additional, and Tran, Nhan L., additional

Published
2022
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42. Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification

Author

Oh, Young Taek, primary, Migliozzi, Simona, additional, Garofano, Luciano, additional, Mohammad, Hasanain, additional, D’Angelo, Fulvio, additional, Najac, Ryan D., additional, Bielle, Franck, additional, Mokhtari, Karima, additional, Sarkaria, Jann N., additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2022
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43. CSIG-08. ABT-414 RESISTANT GBM TUMORS HARBOR THE TEK S466I MUTATION AND EXHIBIT INCREASED STEMNESS

Author

Blomquist, Mylan, primary, Noviello, Teresa, additional, D'Angelo, Fulvio, additional, Sereduk, Christopher, additional, Rabichow, Benjamin, additional, Miller, Aunay, additional, Marin, Bianca-Maria, additional, White, Forest, additional, Sarkaria, Jann, additional, Lasorella, Anna, additional, Iavarone, Antonio, additional, Ceccarelli, Michele, additional, and Tran, Nhan, additional

Published
2021
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44. EPCO-09. LONGITUDINAL ANALYSIS OF DIFFUSE GLIOMA REVEALS CELL STATE DYNAMICS AT RECURRENCE ASSOCIATED WITH CHANGES IN GENETICS AND THE MICROENVIRONMENT

Author

Varn, Frederick, primary, Johnson, Kevin, additional, Wade, Taylor, additional, Malta, Tathiane, additional, Sabedot, Thais, additional, Barthel, Floris, additional, Kim, Hoon, additional, Ahmed, Nazia, additional, Datta, Indrani, additional, Barnholtz-Sloan, Jill, additional, Bakas, Spyridon, additional, D'Angelo, Fulvio, additional, Gan, Hui, additional, Garofano, Luciano, additional, Huse, Jason, additional, Khasraw, Mustafa, additional, Kocakavuk, Emre, additional, Migliozzi, Simona, additional, Ormond, David, additional, Paek, Sun Ha, additional, Van Meir, Erwin, additional, Walenkamp, Annemiek, additional, Watts, Colin, additional, Weller, Michael, additional, Weiss, Tobias, additional, Wesseling, Pieter, additional, Stead, Lucy, additional, Poisson, Laila, additional, Noushmehr, Houtan, additional, Iavarone, Antonio, additional, and Verhaak, Roel, additional

Published
2021
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47. Abstract 97: Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities

Author

Garofano, Luciano, primary, Migliozzi, Simona, additional, Oh, Young Taek, additional, D'Angelo, Fulvio, additional, Najac, Ryan D., additional, Ko, Aram, additional, Frangaj, Brulinda, additional, Caruso, Francesca Pia, additional, Yu, Kai, additional, Yuan, Jinzhou, additional, Zhao, Wenting, additional, Stefano, Anna Luisa Di, additional, Bielle, Franck, additional, Jiang, Tao, additional, Sims, Peter, additional, Suvà, Mario L., additional, Tang, Fuchou, additional, Su, Xiao-Dong, additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2021
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48. Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus

Author

Petrillo, Federica, primary, Iervolino, Anna, additional, Angrisano, Tiziana, additional, Jelen, Sabina, additional, Costanzo, Vincenzo, additional, D’Acierno, Mariavittoria, additional, Cheng, Lei, additional, Wu, Qi, additional, Guerriero, Ilaria, additional, Mazzarella, Maria Cristina, additional, De Falco, Alfonso, additional, D’Angelo, Fulvio, additional, Ceccarelli, Michele, additional, Caraglia, Michele, additional, Capasso, Giovambattista, additional, Fenton, Robert A., additional, and Trepiccione, Francesco, additional

Published
2021
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50. Proteogenomic and metabolomic characterization of human glioblastoma

Author

Wang, Liang-Bo, primary, Karpova, Alla, additional, Gritsenko, Marina A., additional, Kyle, Jennifer E., additional, Cao, Song, additional, Li, Yize, additional, Rykunov, Dmitry, additional, Colaprico, Antonio, additional, Rothstein, Joseph H., additional, Hong, Runyu, additional, Stathias, Vasileios, additional, Cornwell, MacIntosh, additional, Petralia, Francesca, additional, Wu, Yige, additional, Reva, Boris, additional, Krug, Karsten, additional, Pugliese, Pietro, additional, Kawaler, Emily, additional, Olsen, Lindsey K., additional, Liang, Wen-Wei, additional, Song, Xiaoyu, additional, Dou, Yongchao, additional, Wendl, Michael C., additional, Caravan, Wagma, additional, Liu, Wenke, additional, Cui Zhou, Daniel, additional, Ji, Jiayi, additional, Tsai, Chia-Feng, additional, Petyuk, Vladislav A., additional, Moon, Jamie, additional, Ma, Weiping, additional, Chu, Rosalie K., additional, Weitz, Karl K., additional, Moore, Ronald J., additional, Monroe, Matthew E., additional, Zhao, Rui, additional, Yang, Xiaolu, additional, Yoo, Seungyeul, additional, Krek, Azra, additional, Demopoulos, Alexis, additional, Zhu, Houxiang, additional, Wyczalkowski, Matthew A., additional, McMichael, Joshua F., additional, Henderson, Brittany L., additional, Lindgren, Caleb M., additional, Boekweg, Hannah, additional, Lu, Shuangjia, additional, Baral, Jessika, additional, Yao, Lijun, additional, Stratton, Kelly G., additional, Bramer, Lisa M., additional, Zink, Erika, additional, Couvillion, Sneha P., additional, Bloodsworth, Kent J., additional, Satpathy, Shankha, additional, Sieh, Weiva, additional, Boca, Simina M., additional, Schürer, Stephan, additional, Chen, Feng, additional, Wiznerowicz, Maciej, additional, Ketchum, Karen A., additional, Boja, Emily S., additional, Kinsinger, Christopher R., additional, Robles, Ana I., additional, Hiltke, Tara, additional, Thiagarajan, Mathangi, additional, Nesvizhskii, Alexey I., additional, Zhang, Bing, additional, Mani, D.R., additional, Ceccarelli, Michele, additional, Chen, Xi S., additional, Cottingham, Sandra L., additional, Li, Qing Kay, additional, Kim, Albert H., additional, Fenyö, David, additional, Ruggles, Kelly V., additional, Rodriguez, Henry, additional, Mesri, Mehdi, additional, Payne, Samuel H., additional, Resnick, Adam C., additional, Wang, Pei, additional, Smith, Richard D., additional, Iavarone, Antonio, additional, Chheda, Milan G., additional, Barnholtz-Sloan, Jill S., additional, Rodland, Karin D., additional, Liu, Tao, additional, Ding, Li, additional, Agarwal, Anupriya, additional, Amin, Mitual, additional, An, Eunkyung, additional, Anderson, Matthew L., additional, Andrews, David W., additional, Bauer, Thomas, additional, Birger, Chet, additional, Birrer, Michael J., additional, Blumenberg, Lili, additional, Bocik, William E., additional, Borate, Uma, additional, Borucki, Melissa, additional, Burke, Meghan C., additional, Cai, Shuang, additional, Calinawan, Anna P., additional, Carr, Steven A., additional, Cerda, Sandra, additional, Chan, Daniel W., additional, Charamut, Alyssa, additional, Chen, Lin S., additional, Chesla, David, additional, Chinnaiyan, Arul M., additional, Chowdhury, Shrabanti, additional, Cieślik, Marcin P., additional, Clark, David J., additional, Culpepper, Houston, additional, Czernicki, Tomasz, additional, D'Angelo, Fulvio, additional, Day, Jacob, additional, De Young, Stephanie, additional, Demir, Emek, additional, Dhanasekaran, Saravana Mohan, additional, Dhir, Rajiv, additional, Domagalski, Marcin J., additional, Druker, Brian, additional, Duffy, Elizabeth, additional, Dyer, Maureen, additional, Edwards, Nathan J., additional, Edwards, Robert, additional, Elburn, Kimberly, additional, Ellis, Matthew J., additional, Eschbacher, Jennifer, additional, Francis, Alicia, additional, Gabriel, Stacey, additional, Gabrovski, Nikolay, additional, Garofano, Luciano, additional, Getz, Gad, additional, Gillette, Michael A., additional, Godwin, Andrew K., additional, Golbin, Denis, additional, Hanhan, Ziad, additional, Hannick, Linda I., additional, Hariharan, Pushpa, additional, Hindenach, Barbara, additional, Hoadley, Katherine A., additional, Hostetter, Galen, additional, Huang, Chen, additional, Jaehnig, Eric, additional, Jewell, Scott D., additional, Ji, Nan, additional, Jones, Corbin D., additional, Karz, Alcida, additional, Kaspera, Wojciech, additional, Kim, Lyndon, additional, Kothadia, Ramani B., additional, Kumar-Sinha, Chandan, additional, Lei, Jonathan, additional, Leprevost, Felipe D., additional, Li, Kai, additional, Liao, Yuxing, additional, Lilly, Jena, additional, Liu, Hongwei, additional, Lubínski, Jan, additional, Madan, Rashna, additional, Maggio, William, additional, Malc, Ewa, additional, Malovannaya, Anna, additional, Mareedu, Sailaja, additional, Markey, Sanford P., additional, Marrero-Oliveras, Annette, additional, Martinez, Nina, additional, Maunganidze, Nicollette, additional, McDermott, Jason E., additional, McGarvey, Peter B., additional, McGee, John, additional, Mieczkowski, Piotr, additional, Migliozzi, Simona, additional, Modugno, Francesmary, additional, Montgomery, Rebecca, additional, Newton, Chelsea J., additional, Omenn, Gilbert S., additional, Ozbek, Umut, additional, Paklina, Oxana V., additional, Paulovich, Amanda G., additional, Perou, Amy M., additional, Pico, Alexander R., additional, Piehowski, Paul D., additional, Placantonakis, Dimitris G., additional, Polonskaya, Larisa, additional, Potapova, Olga, additional, Pruetz, Barbara, additional, Qi, Liqun, additional, Ramkissoon, Shakti, additional, Resnick, Adam, additional, Richey, Shannon, additional, Riggins, Gregory, additional, Robinson, Karna, additional, Roche, Nancy, additional, Rohrer, Daniel C., additional, Rood, Brian R., additional, Rossell, Larissa, additional, Savage, Sara R., additional, Schadt, Eric E., additional, Shi, Yan, additional, Shi, Zhiao, additional, Shutack, Yvonne, additional, Singh, Shilpi, additional, Skelly, Tara, additional, Sokoll, Lori J., additional, Stawicki, Jakub, additional, Stein, Stephen E., additional, Suh, James, additional, Szopa, Wojciech, additional, Tabor, Dave, additional, Tan, Donghui, additional, Tansil, Darlene, additional, Thangudu, Ratna R., additional, Tognon, Cristina, additional, Traer, Elie, additional, Tsang, Shirley, additional, Tyner, Jeffrey, additional, Um, Ki Sung, additional, Valley, Dana R., additional, Vasaikar, Suhas, additional, Vatanian, Negin, additional, Velvulou, Uma, additional, Vernon, Michael, additional, Wan, Weiqing, additional, Wang, Junmei, additional, Webster, Alex, additional, Wen, Bo, additional, Whiteaker, Jeffrey R., additional, Wilson, George D., additional, Zakhartsev, Yuriy, additional, Zelt, Robert, additional, Zhang, Hui, additional, Zhang, Liwei, additional, Zhang, Zhen, additional, Zhao, Grace, additional, and Zhu, Jun, additional

Published
2021
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