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5 results on '"D'Angelo, M. Grazia"'

1. Idebenone reduces respiratory complications in patients with Duchenne muscular dystrophy

Author

Bernert, G., Knipp, F., Buyse, G.M., Goemans, N., van den Hauwe, M., Voit, T., Doppler, V., Gidaro, T., Cuisset, J.-M., Coopman, S., Schara, U., Lutz, S., Kirschner, J., Borell, S., Will, M., D'Angelo, M.G., Brighina, E., Gandossini, S., Gorni, K., Falcier, E., Politano, L., D'Ambrosio, P., Taglia, A., Verschuuren, J.J.G.M., Straathof, C.S.M., Vílchez Padilla, J.J., Muelas Gómez, N., Sejersen, T., Hovmöller, M., Jeannet, P.-Y., Bloetzer, C., Iannaccone, S., Castro, D., Tennekoon, G., Finkel, R., Bönnemann, C., McDonald, C., Henricson, E., Joyce, N., Apkon, S., Richardson, R.C., McDonald, Craig M., Meier, Thomas, Voit, Thomas, Schara, Ulrike, Straathof, Chiara S.M., D'Angelo, M. Grazia, Bernert, Günther, Cuisset, Jean-Marie, Finkel, Richard S., Goemans, Nathalie, Rummey, Christian, Leinonen, Mika, Spagnolo, Paolo, and Buyse, Gunnar M.

Published
2016
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3. Idebenone reduces respiratory complications in patients with Duchenne muscular dystrophy

Author

McDonald, Craig M., primary, Meier, Thomas, additional, Voit, Thomas, additional, Schara, Ulrike, additional, Straathof, Chiara S.M., additional, D'Angelo, M. Grazia, additional, Bernert, Günther, additional, Cuisset, Jean-Marie, additional, Finkel, Richard S., additional, Goemans, Nathalie, additional, Rummey, Christian, additional, Leinonen, Mika, additional, Spagnolo, Paolo, additional, Buyse, Gunnar M., additional, Bernert, G., additional, Knipp, F., additional, Buyse, G.M., additional, Goemans, N., additional, van den Hauwe, M., additional, Voit, T., additional, Doppler, V., additional, Gidaro, T., additional, Cuisset, J.-M., additional, Coopman, S., additional, Schara, U., additional, Lutz, S., additional, Kirschner, J., additional, Borell, S., additional, Will, M., additional, D'Angelo, M.G., additional, Brighina, E., additional, Gandossini, S., additional, Gorni, K., additional, Falcier, E., additional, Politano, L., additional, D'Ambrosio, P., additional, Taglia, A., additional, Verschuuren, J.J.G.M., additional, Straathof, C.S.M., additional, Vílchez Padilla, J.J., additional, Muelas Gómez, N., additional, Sejersen, T., additional, Hovmöller, M., additional, Jeannet, P.-Y., additional, Bloetzer, C., additional, Iannaccone, S., additional, Castro, D., additional, Tennekoon, G., additional, Finkel, R., additional, Bönnemann, C., additional, McDonald, C., additional, Henricson, E., additional, Joyce, N., additional, Apkon, S., additional, and Richardson, R.C., additional

Published
2016
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4. In vivo biolistic technique in control and mdx dystrophic mice

Author

Ausenda, Carlo D., primary, Bresolin, Nereo, additional, De Liso, Alberto, additional, D'Angelo, M. Grazia, additional, Moggio, Maurizio, additional, Del Bo, Roberto, additional, Gallanti, Andrea, additional, Comi, Giacomo P., additional, Torrente, Yvan, additional, Bordoni, Andreina, additional, and Scarlato, Guglielmo, additional

Published
1996
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5. Point mutations and a large intragenic deletion in SPG11 in complicated spastic paraplegia without thin corpus callosum.

Author

Crimella, C., Arnoldi, A., Crippa, F., Mostacciuolo, M. L., Boaretto, F., Sironi, M., D'Angelo, M. Grazia, Manzoni, S., Piccinini, L., Turconi, A. C., Toscano, A., Musumeci, O., Benedetti, S., Fazio, R., Bresolin, N., Daga, A., Martinuzzi, A., and Bassi, M. T.

Subjects
PARAPLEGIA, PARALYSIS, GENETIC disorders, CORPUS callosum, LOCUS (Genetics), GENETIC mutation, MEDICAL genetics, MEDICAL research
Abstract

Background: Hereditary spastic paraplegia (HSP) with thin corpus callosum (HSP-TCC) is a frequent subtype of complicated HSP clinically characterised by slowly progressive spastic paraparesis with cognitive impairment and thin corpus callosum (TCC). SPG11, the gene associated with the major locus involved, encodes spatacsin, a protein of unknown function. Methods: Different types of mutations were identified in patients with the complex form of HSP (cHSP) including TCC. We screened a series of 45 index patients with different types of cHSP with (n = 10) and without (n = 35) TCC. Results: Ten mutations, of which five are novel, were detected in seven patients. Of importance, three out of seven mutated patients present with cHSP without TCC. Among the novel mutations identified, we characterised a large intragenic rearrangement deleting 2.6 kb of the SPG11 gene. The rearrangement is due to non-allelic homologous recombination between Alu sequences flanking the breakpoints. Conclusions: These findings expand the mutation spectrum of SPG11 and suggest that SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. This helps to define further clinical and molecular criteria for a correct diagnosis of the SPG11 related form of cHSP. In addition, the intragenic deletion detected here, and the mechanism involved, both provide clues to address the issue of SPG11 missing mutant alleles previously reported. [ABSTRACT FROM AUTHOR]

Published
2009
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