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16 results on '"D'Armiento, Eleonora"'

1. Iodized Salt May Not Be Sufficient to Guarantee an Adequate Iodine Intake in Pregnant Women

Author

Spina, Vincenzo, primary, Baldini, Enke, additional, Cardarelli, Silvia, additional, Oliva, Cosimo, additional, Venarubea, Stefano, additional, Faraoni, Franca, additional, Pastore, Giovanni, additional, Tittoni, Rachele, additional, Musella, Angela, additional, Squarcella, Antonia, additional, Lori, Eleonora, additional, Renzi, Elisabetta, additional, Feroci, Roberta, additional, Mastrodonato, Flavia, additional, Ciferri, Fabiola, additional, Virili, Camilla, additional, Centanni, Marco, additional, Fabiani, Cristina, additional, Rago, Rocco, additional, Schiavi, Michele Carlo, additional, Palazzetti, Pierluigi, additional, D’Armiento, Eleonora, additional, Cantisani, Vito, additional, Sorrenti, Salvatore, additional, and Ulisse, Salvatore, additional

Published
2023
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3. Insights on the Association between Thyroid Diseases and Colorectal Cancer

Author

Gagliardi, Federica, primary, Baldini, Enke, additional, Lori, Eleonora, additional, Cardarelli, Silvia, additional, Pironi, Daniele, additional, Lauro, Augusto, additional, Tripodi, Domenico, additional, Palumbo, Piergaspare, additional, D’Armiento, Eleonora, additional, Cavallaro, Giuseppe, additional, Polistena, Andrea, additional, D’Orazi, Valerio, additional, Sibio, Simone, additional, Fallahi, Poupak, additional, Antonelli, Alessandro, additional, D’Andrea, Vito, additional, Ulisse, Salvatore, additional, and Sorrenti, Salvatore, additional

Published
2023
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5. Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia

Author

Ciacciarelli, Marco, Caruso, Gianluca, Rengo, Marco, Maceroni, Piero, Misurale, Carmen, D’Armiento, Eleonora, Polidoro, Alessandro, Napoli, Cristina, Lombardini, Alberto, Ceratti, Umberto, Colunga Biancatelli, Ruben Manuel Luciano, Calvosa, Leonardo, Milanese, Romina, Ferri, Sonia, Massaro, Teresa, Lorusso, Andrea, Sorrentino, Veronica, Petrozza, Vincenzo, and Iuliano, Luigi

Subjects
endocrine system diseases, Article Subject
Abstract

Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient’s clinical status deteriorated rapidly, and he died in our department from acute renal failure.

Published
2020
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6. Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study

Author

Sorrenti, Salvatore, primary, Carbotta, Giovanni, additional, Di Matteo, Filippo Maria, additional, Catania, Antonio, additional, Pironi, Daniele, additional, Tartaglia, Francesco, additional, Tarroni, Danilo, additional, Gagliardi, Federica, additional, Tripodi, Domenico, additional, Watanabe, Mikiko, additional, Mariani, Stefania, additional, D’Armiento, Eleonora, additional, Fallahi, Poupak, additional, Sindoni, Alessandro, additional, De Vito, Corrado, additional, Antonelli, Alessandro, additional, Ulisse, Salvatore, additional, and Baldini, Enke, additional

Published
2020
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7. Expression and prognostic value of the cell polarity PAR complex members in thyroid cancer

Author

Tuccilli, Chiara, Baldini, Enke, Arlot Bonnemains, Yannick, Chesnel, Frank, Sorrenti, Salvatore, De Vito, Corrado, D'Armiento, Eleonora, Antonelli, Alessandro, Fallahi, Poupak, Watutantrige, Sara, Tartaglia, Francesco, Barollo, Susi, Mian, Caterina, Arcieri, Stefano, Mascagni, Domenico, Pironi, Daniele, Bononi, Marco, Vergine, Massimo, Monti, Massimo, Filippini, Angelo, Ulisse, Salvatore, WATUTANTRIGE FERNANDO, Sara, Department of Experimental Medicine, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Department of Surgical Sciences, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Internal Medicine, University of Pisa - Università di Pisa, Department of Medical and Surgical Sciences, Università degli Studi di Padova = University of Padua (Unipd), Sapienza University of Rome [C26A14RNFY, C26N145E4T], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Universita degli Studi di Padova, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
0301 basic medicine, Cancer Research, medicine.medical_specialty, Cell, Anaplastic thyroid carcinoma, Apico-basal polarity, APKC, Papillary thyroid carcinoma, PAR complex, PARD3, PARD6, Thyroid, Biology, Apico-basal polarity, 03 medical and health sciences, Internal medicine, Cell polarity, Gene expression, medicine, Anaplastic thyroid carcinoma, APKC, Papillary thyroid carcinoma, PAR complex, PARD3, PARD6, Thyroid, Oncology, Thyroid cancer, [SDV.GEN]Life Sciences [q-bio]/Genetics, Oncogene, Cancer, Cell cycle, medicine.disease, Molecular medicine, 3. Good health, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Cancer research
Abstract

International audience; Establishment and maintenance of the apical basal cell polarity, required for proper replication, migration, specialized functions and tissue morphogenesis, relies on three evolutionary conserved complexes: PAR, CRUMBS and SCRIBBLE. Loss of cell polarity/cohesiveness (LOP/C) is implicated in cancer progression, and members of the polarity complex have been described as either oncogenes or oncosuppressors. However, no information on their role in thyroid cancer (TC) progression is available. In the present study, we evaluated the gene expression of the PAR complex members aPKCt, PARD3 alpha/beta and PARD6 alpha/beta/gamma in 95 papillary TC (PTC), compared to their normal matched tissues and in 12 anaplastic TC (ATC). The mRNA and protein levels of investigated genes were altered in the majority of PTC and ATC tissues. In PTC, univariate analysis showed that reduced expression of aPKCt, PARD3 beta and PARD6 gamma mRNAs is associated with increased tumor size, and the reduced expression of PARD3 beta mRNA is associated also with recurrences. Multivariate analysis demonstrated that the presence of lymph node metastasis at diagnosis and the reduced expression of PARD3 beta are independent risk factors for recurrences, with hazard ratio, respectively, of 8.21 (P=0.006) and 3.04 (P=0.029). The latter result was confirmed by the Kaplan-Meier analysis, which evidenced the association between decreased PARD3 beta mRNA levels and shorter disease-free interval. In conclusion, we demonstrated that the expression of PAR complex components is deregulated in the majority of PTC and there is a general trend towards their reduction in ATC tissues. Moreover, a prognostic value for the PARD3 beta gene in PTCs is suggested.

Published
2017

8. Combined Hepatocholangiocarcinoma Associated with Humoral Hypercalcemia of Malignancy and Chronic Inflammatory Demyelinating Polyneuropathy

Author

Colunga Biancatelli, Ruben Manuel Luciano, Ciacciarelli, Marco, Polidoro, Alessandro, Clemenzi, Piera, Congedo, Viviana, Calvosa, Leonardo, D’Armiento, Eleonora, Misurale, Carmen, Bellini, Davide, Badia, Stefano, Mancini, Massimiliano, Petrozza, Vincenzo, and Iuliano, Luigi

Subjects
Article Subject
Abstract

Paraneoplastic syndromes are often a diagnostic challenge to doctors and may have a heterogeneous presentation, including humoral hypercalcemia of malignancy (HHM), most commonly caused by squamous cell cancer and renal, ovarian, endometrial, and breast cancer. Chronic inflammatory demyelinating polyneuropathy (CIDP) has been described in patients affected by several types of cancer, especially hematologic malignancies, and a possible paraneoplastic pathogenesis of this neurological disease has been suggested. This report describes a 56-year-old man with a history of CIDP diagnosed 3 months earlier and persistently elevated aminotransferases for 18 months who was admitted to our internal medicine unit with abdominal pain, fatigue, and severe hypercalcemia with low serum intact parathyroid hormone. Parathyroid hormone-related protein (PTH-rP) was markedly high. Liver imaging showed a large hepatic mass in the right lobe, and percutaneous ultrasound-guided biopsy revealed histopathological findings consistent with a combined hepatocholangiocarcinoma (CHCC). We supposed that both HHM and CIDP could represent a paraneoplastic manifestation of CHCC.

Published
2019
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9. PD-1 Ligand Expression in Epithelial Thyroid Cancers: Potential Clinical Implications

Author

Ulisse, Salvatore, primary, Tuccilli, Chiara, additional, Sorrenti, Salvatore, additional, Antonelli, Alessandro, additional, Fallahi, Poupak, additional, D’Armiento, Eleonora, additional, Catania, Antonio, additional, Tartaglia, Francesco, additional, Amabile, Maria, additional, Giacomelli, Laura, additional, Metere, Alessio, additional, Cornacchini, Nicola, additional, Pironi, Daniele, additional, Carbotta, Giovanni, additional, Vergine, Massimo, additional, Monti, Massimo, additional, and Baldini, Enke, additional

Published
2019
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10. Vitiligo and Autoimmune Thyroid Disorders

Author

Baldini, Enke, primary, Odorisio, Teresa, additional, Sorrenti, Salvatore, additional, Catania, Antonio, additional, Tartaglia, Francesco, additional, Carbotta, Giovanni, additional, Pironi, Daniele, additional, Rendina, Roberta, additional, D’Armiento, Eleonora, additional, Persechino, Severino, additional, and Ulisse, Salvatore, additional

Published
2017
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11. Deregulated expression of VHL mRNA variants in papillary thyroid cancer

Author

Baldini, Enke, primary, Tuccilli, Chiara, additional, Arlot-Bonnemains, Yannick, additional, Chesnel, Frank, additional, Sorrenti, Salvatore, additional, De Vito, Corrado, additional, Catania, Antonio, additional, D'Armiento, Eleonora, additional, Antonelli, Alessandro, additional, Fallahi, Poupak, additional, Watutantrige-Fernando, Sara, additional, Tartaglia, Francesco, additional, Barollo, Susi, additional, Mian, Caterina, additional, Bononi, Marco, additional, Arceri, Stefano, additional, Mascagni, Domenico, additional, Vergine, Massimo, additional, Pironi, Daniele, additional, Monti, Massimo, additional, Filippini, Angelo, additional, and Ulisse, Salvatore, additional

Published
2017
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12. Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules

Author

Ulisse, Salvatore, primary, Bosco, Daniela, additional, Nardi, Francesco, additional, Nesca, Angela, additional, D’Armiento, Eleonora, additional, Guglielmino, Valeria, additional, De Vito, Corrado, additional, Sorrenti, Salvatore, additional, Pironi, Daniele, additional, Tartaglia, Francesco, additional, Arcieri, Stefano, additional, Catania, Antonio, additional, Monti, Massimo, additional, Filippini, Angelo, additional, and Ascoli, Valeria, additional

Published
2017
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13. Cervical lymph node metastases from thyroid cancer: does thyroglobulin and calcitonin measurement in fine needle aspirates improve the diagnostic value of cytology?

Author

Baldini, Enke, primary, Sorrenti, Salvatore, additional, Di Gioia, Cira, additional, De Vito, Corrado, additional, Antonelli, Alessandro, additional, Gnessi, Lucio, additional, Carbotta, Giovanni, additional, D’Armiento, Eleonora, additional, Miccoli, Paolo, additional, De Antoni, Enrico, additional, and Ulisse, Salvatore, additional

Published
2013
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15. Iodine Status in Schoolchildren and Pregnant Women of Lazio, a Central Region of Italy.

Author

Baldini, Enke, Virili, Camilla, D'Armiento, Eleonora, Centanni, Marco, and Ulisse, Salvatore

Abstract

The inhabitants of Lazio, similarly to those of other Italian regions, have been historically exposed to the detrimental effects of an inadequate intake of iodine. The latter is a micronutrient essential for the biosynthesis of thyroid hormones (TH). Iodine deficiency is responsible for a number of adverse effects on human health known as iodine deficiency disorders (IDD), the most common of which worldwide are goiter and hypothyroidism. In order to reduce IDD, a national salt iodination program was started in Italy in 2005. In this article we reviewed the available data regarding iodine intake in the Lazio population before and after the introduction of the national salt iodination program, in order to evaluate its efficacy and the eventual problem(s) limiting its success. On the whole, the information acquired indicates that, following the introduction of the program, the dietary iodine intake in the Lazio population is improved. There is, however, still much work ahead to ameliorate the iodine prophylaxis in this region. In fact, although a generally adequate iodine intake in school-age children has been observed, there are still areas where a mild iodine insufficiency is present. Moreover, two independent epidemiological surveys on pregnant women evidenced a low urinary iodine concentration with respect to the reference range conceived by the World Health Organization. These findings demonstrate the need for greater attention to the iodine prophylaxis by health care providers (i.e., obstetricians, gynecologists, pediatricians, etc.), and the implementation of effective advertising campaigns aimed at increasing the knowledge and awareness of the favorable effects of iodine supplementation on population health. [ABSTRACT FROM AUTHOR]

Published
2019
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16. Incidence of Thyroid Cancer in Italian Contaminated Sites.

Author

Benedetti M, Zona A, Contiero P, D'Armiento E, Iavarone I, and Airtum Working Group

Subjects
Adolescent, Adult, Female, Humans, Incidence, Italy epidemiology, Male, Young Adult, Environmental Exposure adverse effects, Environmental Pollution adverse effects, Thyroid Neoplasms chemically induced, Thyroid Neoplasms epidemiology
Abstract

Some human literature suggests a possible role of endocrine disruptors (EDs) exposure in thyroid cancer (TC) development. We investigated TC incidence in selected Italian National Priority Contaminated Sites (NPCS) with documented presence of EDs considered thyroid carcinogens. Adjusted Standardized Incidence Ratios (SIRs), with their 90% confidence intervals, were computed by gender, and age-specific groups (aged 15-39 years, and 40 years or over) for each NPCS in the period 2006 to 2013. In the age group of 15-39 years, a significant excess of TC risk was found in two NPCSs in males; non-significant excess risks were observed in four NPCSs in males, and in five in females. In the age group of 40 years and over, significant excess risks were found in six NPCSs in males and in seven NPCSs in females; non-significant excess risks were identified in two NPCSs in males and females. The findings of several excesses in incidence, mainly observed in adults aged 40 years or over, are suggestive of a possible adverse effect associated with residence in NPCSs, even if a role of other factors cannot be excluded, due to the adoption of an ecological study design. Future analytical studies are needed to clarify if EDs are a TC risk factor for individuals living in NPCSs.

Published
2020
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