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16,849 results on '"Département de médecine"'

1. 24-hour Ambulatory Blood Pressure Monitoring in Patients With Blood Pressure Above Thresholds in General Practice (MAPAGE)

Author: Association pour le Développement de la Recherche en Médecine Générale (ADRMG), Département de Médecine Générale de Dijon (DMG), and Dr Claire ZABAWA, University senior registrar
Published: 2018

2. HEMITOX : Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke

Author: J. Rebeyrol Hospital in Limoges, Rennes University Hospital, Center of Physical Medicine and Rehabilitation (Notre Dame de Lourdes Center in Rennes), Saint Jacques Hospital in Nantes, Centre Hospitalier Universitaire de Saint Etienne, Centre Régional de Département de médecine physique et réadaptation CHU-C3RF in Angers, Centre Hospitalier Universitaire de Besancon, and Pr Franck DURIF
Published: 2011

3. Delayed Humoral Response After 2 Doses of the BNT162b2 Vaccine in a Belgian Kidney Transplant Cohort.

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Département de médecine interne et services associés, Georgery, Hélène, Devresse, Arnaud, Saad Albichr, Imane, Lucas, Sophie, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Scohy, Anaïs, Kabamba Mukadi, Benoît, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Département de médecine interne et services associés, Georgery, Hélène, Devresse, Arnaud, Saad Albichr, Imane, Lucas, Sophie, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Scohy, Anaïs, Kabamba Mukadi, Benoît, Goffin, Eric, and Kanaan, Nada
Published: 2022

4. Immunosuppression and SARS-CoV-2 Infection in Kidney Transplant Recipients.

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Département de médecine interne et services associés, Devresse, Arnaud, De Greef, Julien, Yombi, Jean Cyr, Belkhir, Leïla, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Département de médecine interne et services associés, Devresse, Arnaud, De Greef, Julien, Yombi, Jean Cyr, Belkhir, Leïla, Goffin, Eric, and Kanaan, Nada
Abstract: Kidney transplant recipients (KTRs) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have an increased risk of mortality compared with the general population and hemodialysis patients. As these patients are immunosuppressed, it might seem obvious to attribute this excess mortality to the impaired immunity induced by immunosuppression. In line with this reasoning is the low immune response, both cellular and humoral, that KTRs mount in response to the anti-SARS-CoV-2 vaccine; however, acute respiratory distress syndrome associated with coronavirus disease 2019 is triggered by a state of inflammation and cytokine release syndrome that lead to pulmonary damage and increased mortality. In that context, immunosuppressive treatment dampening the immune response could, in theory, be potentially beneficial. This review aims at analyzing the current knowledge on the impact of immunosuppressive treatment on mortality in SARS-CoV-2-infected KTRs, the optimal management of immunosuppression in the coronavirus disease 2019 era, and the vaccine response and management in immunosuppressed KTRs.
Published: 2022

5. Impact of therapeutic plasma exchange on acquired vaccinal anti-SARS-CoV-2 antibodies.

Author: UCL - (SLuc) Service d'hématologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Lambert, Catherine, Scohy, Anaïs, Yombi, Jean Cyr, Goffin, Eric, Devresse, Arnaud, UCL - (SLuc) Service d'hématologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Lambert, Catherine, Scohy, Anaïs, Yombi, Jean Cyr, Goffin, Eric, and Devresse, Arnaud
Published: 2022

6. Attenuated anti-SARS-CoV-2 antibody response to vaccination in patients with rheumatic diseases.

Author: UCL - (SLuc) Service de rhumatologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, Manolache, Narcis-George, Ursachi, Vasile, Scohy, Anaïs, Desmet, Charlotte, Yombi, Jean Cyr, Nzeusseu Toukap, Adrien, Stoenoiu, Maria Simona, UCL - (SLuc) Service de rhumatologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, Manolache, Narcis-George, Ursachi, Vasile, Scohy, Anaïs, Desmet, Charlotte, Yombi, Jean Cyr, Nzeusseu Toukap, Adrien, and Stoenoiu, Maria Simona
Abstract: Dear Editor, SARS-CoV-2 vaccination has demonstrated efficacy in large clin- ical trials but immunocompromised patients including patients with rheumatic diseases are often excluded. A recent letter in Jour- nal of Infection identified an anti-receptor binding domain (RBD) antibody (Ab) threshold below which protection against SARS-CoV- 2 infection is inferior to 90% [ ... ].
Published: 2022

7. Eosinophilic Fasciitis Unmasking a Lung Cancer

Author: UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/SLUC - Pôle St.-Luc, Vandamme, Emilie, Hainaut, Philippe, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/SLUC - Pôle St.-Luc, Vandamme, Emilie, and Hainaut, Philippe
Abstract: No abstract available
Published: 2022

8. Dynamics of spreading of SARS-CoV-2 in a Belgian hemodialysis facility: The importance of the analysis of viral strains.

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, Labriola, Laura, Ruelle, Jean, Scohy, Anaïs, Seghers, François, Perlot, Quentin, De Greef, Julien, Desmet, Christine, Romain, Cécile, Yombi, Jean Cyr, Rodriguez-Villalobos, Hector, Kabamba Mukadi, Benoît, Jadoul, Michel, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, Labriola, Laura, Ruelle, Jean, Scohy, Anaïs, Seghers, François, Perlot, Quentin, De Greef, Julien, Desmet, Christine, Romain, Cécile, Yombi, Jean Cyr, Rodriguez-Villalobos, Hector, Kabamba Mukadi, Benoît, and Jadoul, Michel
Abstract: In-center maintenance hemodialysis (HD) patients are at high risk of acquiring coronavirus disease 2019 (COVID-19) by cross-contamination inside the unit. The aim of this study was to assess retrospectively the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission during the very first pandemic phase (March-July 2020) in a cohort of in-center maintenance HD patients and in nurses the same HD facility, using a phylogenetic approach. All SARS-CoV-2 quantitative reverse-transcription polymerase chain reaction positive patients and nurses from our HD unit-respectively 10 out of 98, and 8 out of 58- and two other positive patients dialyzed in our self-care unit were included. Whole-genome viral sequencing and phylogenetic analysis supported the cluster investigation. Five positive patients were usually dialyzed in the same room and same shift before their COVID-19 diagnosis was made. Viral sequencing performed on 4/5 patients' swabs showed no phylogenetic link between their viruses. The fifth patient (whose virus could not be sequenced) was dialyzed at the end of the dialysis room and was treated by a different nurse than the one in charge of the other patients. Three nurses shared the same virus detected in both self-care patients (one of them had been transferred to our in-center facility). The epidemiologically strongly suspected intra-unit cluster could be ruled out by viral genome sequencing. The infection control policy did not allow inter-patient contamination within the HD facility, in contrast to evidence of moderate dissemination within the nursing staff and in the satellite unit. Epidemiologic data without phylogenetic confirmation might mislead the interpretation of the dynamics of viral spreading within congregate settings.
Published: 2022

9. Sino-Orbital Aspergillosis in a Kidney Transplant Recipient.

Author: UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service d'ophtalmologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, Maalouli, Christian, De Greef, Julien, Duprez, Thierry, Devresse, Arnaud, Huart, Caroline, Coutel, Maëlle, Demoulin, Nathalie, Belkhir, Leïla, Kanaan, Nada, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service d'ophtalmologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, Maalouli, Christian, De Greef, Julien, Duprez, Thierry, Devresse, Arnaud, Huart, Caroline, Coutel, Maëlle, Demoulin, Nathalie, Belkhir, Leïla, and Kanaan, Nada
Abstract: Sino-orbital aspergillosis is a rare and severe infection mostly seen in immunocompromised individuals in which diagnosis may be challenging with potentially life-threatening consequences. Infection usually starts in the paranasal sinuses with secondary spreading to the adjacent orbits. Here, we report the case of a kidney transplant recipient who presented with proven invasive sino-orbital aspergillosis resulting in irreversible loss of vision despite surgical management and antifungal therapy. We review the literature with a focus on clinical presentation, diagnostic tools, and recommended treatment in the context of kidney transplantation.
Published: 2022

10. Imaging in Post-COVID Lung Disease: Does F-FDG PET/CT Have the Key?

Author: UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de médecine nucléaire, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Gheysens, Olivier, Belkhir, Leïla, Jamar, François, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de médecine nucléaire, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Gheysens, Olivier, Belkhir, Leïla, and Jamar, François
Abstract: No abstract available
Published: 2022

11. Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19.

Author: UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - SSS/DDUV/CBIO - Computational Biology and Bioinformatics, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/DDUV - Institut de Duve, Dewulf, Joseph, Martin, Manon, Marie Sandrine, Oguz, Fabie, Belkhir, Leïla, De Greef, Julien, Yombi, Jean Cyr, Wittebole, Xavier, Laterre, Pierre-François, Jadoul, Michel, Gatto, Laurent, Bommer, Guido, Morelle, Johann, UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - SSS/DDUV/CBIO - Computational Biology and Bioinformatics, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/DDUV - Institut de Duve, Dewulf, Joseph, Martin, Manon, Marie Sandrine, Oguz, Fabie, Belkhir, Leïla, De Greef, Julien, Yombi, Jean Cyr, Wittebole, Xavier, Laterre, Pierre-François, Jadoul, Michel, Gatto, Laurent, Bommer, Guido, and Morelle, Johann
Abstract: SARS-CoV-2 causes major disturbances in serum metabolite levels, associated with severity of the immune response. Despite the numerous advantages of urine for biomarker discovery, the potential association between urine metabolites and disease severity has not been investigated in coronavirus disease 2019 (COVID-19). In a proof-of-concept study, we performed quantitative urine metabolomics in patients hospitalized with COVID-19 and controls using LC-MS/MS. We assessed whether metabolites alterations were associated with COVID-19, disease severity, and inflammation. The study included 56 patients hospitalized with COVID-19 (26 non-critical and 30 critical disease); 16 healthy controls; and 3 controls with proximal tubule dysfunction unrelated to SARS-CoV-2. Metabolomic profiling revealed a major urinary increase of tryptophan metabolites kynurenine (P < 0.001), 3-hydroxykynurenine (P < 0.001) and 3-hydroxyanthranilate (P < 0.001) in SARS-CoV-2 infected patients. Urine levels of kynurenines were associated with disease severity and systemic inflammation (kynurenine, r 0.43, P = 0.001; 3-hydroxykynurenine, r 0.44, P < 0.001). Increased urinary levels of neutral amino acids and imino acid proline were also common in COVID-19, suggesting specific transport defects. Urine metabolomics identified major alterations in the tryptophan-kynurenine pathway, consistent with changes in host metabolism during SARS-CoV-2 infection. The association between increased urinary levels of kynurenines, inflammation and COVID-19 severity supports further evaluation of these easily available biomarkers.
Published: 2022

12. Liver hypodense infectious lesions: Is it only bacteria, parasites or fungi?

Author: UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service de gastro-entérologie, Hoornaert, E, Yombi, J C, Coubeau, L, Baldin, P, Dahlqvist, G, Yildiz, H, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service de gastro-entérologie, Hoornaert, E, Yombi, J C, Coubeau, L, Baldin, P, Dahlqvist, G, and Yildiz, H
Abstract: No abstract available
Published: 2022

13. Short-Term Pain Evolution and Treatment Success of Pulpotomy as Irreversible Pulpitis Permanent Treatment: A Non-Randomized Clinical Study.

Author: UCL - (SLuc) Département de médecine dentaire et stomatologie, Beauquis, Julien, Setbon, Hugo M, Dassargues, Charles, Carsin, Pierre, Aryanpour, Sam, Van Nieuwenhuysen, Jean-Pierre, Leprince, Julian G, UCL - (SLuc) Département de médecine dentaire et stomatologie, Beauquis, Julien, Setbon, Hugo M, Dassargues, Charles, Carsin, Pierre, Aryanpour, Sam, Van Nieuwenhuysen, Jean-Pierre, and Leprince, Julian G
Abstract: The objective of this work was to evaluate (1) the short-term evolution of pain and (2) the treatment success of full pulpotomy as permanent treatment of irreversible pulpitis in mature molars. The study consisted of a non-randomized comparison between a test group ( = 44)-full pulpotomy performed by non-specialist junior practitioners, and a control group ( = 40)-root canal treatments performed by specialized endodontists. Short-term pain score (Heft-Parker scale) was recorded pre-operatively, then at 24 h and 7 days post-operatively. Three outcomes were considered for treatment success: , and success. For short-term evolution of pain, a non-parametric Wilcoxon test was performed (significance level = 0.05). For treatment success, a Pearson Chi square or Fisher test were performed (significance level = 0.017-Bonferroni correction). There was no significant difference between and control groups neither regarding short term evolution of pain at each time point, nor regarding (80% and 90%, respectively) or success (77% and 67%, respectively). However, a significant difference in success was observed (94% and 69%, respectively). The present work adds to the existing literature to support that pulpotomy as permanent treatment could be considered as an acceptable and conservative treatment option, potentially applied by a larger population of dentists.
Published: 2022

14. Giant Cell Arteritis: The Place of F-FDG PET/CT and Serum Haptoglobin Level.

Author: UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département de médecine interne et services associés, Yildiz, Halil, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département de médecine interne et services associés, and Yildiz, Halil
Abstract: no abstract available
Published: 2022

15. Factors predicting in-hospital all-cause mortality in COVID 19 patients at the Laquintinie Hospital Douala, Cameroon.

Author: UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Ebongue, Marie Solange Ndom, Lemogoum, Daniel, Endale-Mangamba, Laurent Mireille, Barche, Blaise, Eyoum, Christian, Simo Yomi, Styve Hermane, Mekolo, David, Ngambi, Vincent, Doumbe, Jacques, Sike, Christiane Medi, Boombhi, Jerome, Ngondi, Grace, Biholong, Christian, Kamdem, Josephine, Mbenoun, Liliane, Tegeu, Calixthe Kuaté, Djomou, Armel, Dzudie, Anastase, Kamdem, Felicité, Ntock, Ferdinand Ndom, Mfeukeu, Liliane Kuaté, Sobngwi, Eugène, Penda, Ida, Njock, Richard, Essomba, Noel, Yombi, Jean Cyr, Ngatchou, William, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Ebongue, Marie Solange Ndom, Lemogoum, Daniel, Endale-Mangamba, Laurent Mireille, Barche, Blaise, Eyoum, Christian, Simo Yomi, Styve Hermane, Mekolo, David, Ngambi, Vincent, Doumbe, Jacques, Sike, Christiane Medi, Boombhi, Jerome, Ngondi, Grace, Biholong, Christian, Kamdem, Josephine, Mbenoun, Liliane, Tegeu, Calixthe Kuaté, Djomou, Armel, Dzudie, Anastase, Kamdem, Felicité, Ntock, Ferdinand Ndom, Mfeukeu, Liliane Kuaté, Sobngwi, Eugène, Penda, Ida, Njock, Richard, Essomba, Noel, Yombi, Jean Cyr, and Ngatchou, William
Abstract: Despite being a global pandemic, little is known about the factors influencing in-hospital mortality of COVID-19 patients in sub-Saharan Africa. This study aimed to provide data on in-hospital mortality among COVID-19 patients hospitalized in a single large center in Cameroon. A hospital-based prospective follow-up was conducted from March 18 to June 30, 2020, including patients >18 years with positive PCR for SARS-COV-2 on nasopharyngeal swab admitted to the Laquintinie Douala hospital COVID unit. Predictors of in-hospital mortality were assessed using Kaplan Meir survival curves and Weibull regression for the accelerated time failure model. Statistical significance was considered as p < 0.05. Overall 712 patients (65,7% men) were included, mean age 52,80 ± 14,09 years. There were 580 (67,8% men) in-hospital patients. The median duration of hospital stay was eight days. The in-hospital mortality was 22.2%. Deceased patients compared to survivors were significantly older, had a higher temperature, respiratory rate, and heart rate, and lowest peripheral oxygen saturation at admission. After adjusting for age, sex, and other clinical patient characteristics, increased heart rate, increased temperature, decreased peripheral oxygen saturation. The critical clinical status was significantly associated with increased in-hospital mortality. In contrast, hospitalization duration greater than eight days and the use of hydroxychloroquine (HCQ) + azithromycin (AZM) therapy was associated with decreased risk of in-hospital mortality. One in five hospitalized COVID-19 patients die in a low-middle income setting. Critical clinical status, dyspnea, and increased heart rate were predictors of in-hospital mortality. This study will serve as a prerequisite for more robust subsequent follow-up studies. Also, these results will aid in revising national guidelines for the management of COVID-19 in Cameroon.
Published: 2022

16. Pyoderma gangrenosum induced by transcutaneous electrical nerve stimulation: a case report with literature review.

Author: UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Centre de malformations vasculaires congénitales, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service de dermatologie, Costescu Strachinaru, Diana Isabela, De Greef, Axel, Marot, Liliane, Lerate, Valérie, Paridaens, Marie-Sophie, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Centre de malformations vasculaires congénitales, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service de dermatologie, Costescu Strachinaru, Diana Isabela, De Greef, Axel, Marot, Liliane, Lerate, Valérie, and Paridaens, Marie-Sophie
Abstract: Pyoderma gangrenosum (PG) is one of the neutrophilic dermatosis, a heterogenous group of rare inflammatory diseases affecting the skin. It is often associated with systemic diseases such as inflammatory bowel disease, rheumatoid arthritis or hematological malignancies. Classical PG is characterized by painful ulcers with violaceous, undermined border, often developing at sites of injury because of the typical pathergy phenomenon. Because of its polymorphic presentation, misdiagnosis and delayed diagnosis are common. We present a case of PG occurring after transcutaneous electrical nerve stimulation (TENS) in a young female patient with ulcerative colitis. Although electric current has previously been incriminated as a trigger for PG, to the best of our knowledge this is the first case precipitated by TENS. We report a typical case of PG occurring after an unusual stimulus and highlight the challenges that the diagnosis of this relatively rare pathology poses to the clinician.
Published: 2022

17. The Role of Quantitative and Semi-quantitative [F]FDG-PET/CT Indices for Evaluating Disease Activity and Management of Patients With Dermatomyositis and Polymyositis.

Author: UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de médecine nucléaire, UCL - (SLuc) Centre du cancer, Yildiz, Halil, D'abadie, Philippe, Gheysens, Olivier, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de médecine nucléaire, UCL - (SLuc) Centre du cancer, Yildiz, Halil, D'abadie, Philippe, and Gheysens, Olivier
Abstract: Idiopathic inflammatory myopathies (IIM) are considered systemic diseases involving different organs and some subtypes are associated with increased cancer risk. In this review, we provide a comprehensive summary of the current use and potential applications of (semi-)quantitative [F]FDG-PET/CT indices in patients with IIM focusing on dermatomyositis and polymyositis. Visual interpretation and (semi-)quantitative [F]FDG-PET indices have a good overall performance to detect muscle activity but objective, robust and standardized interpretation criteria are currently lacking. [F]FDG-PET/CT is a suitable modality to screen for malignancy in patients with myositis and may be a promising tool to detect inflammatory lung activity and to early identify patients with rapidly progressive lung disease. The latter remains to be determined in large, prospective comparative trials.
Published: 2022

18. Nirmatrelvir-ritonavir chez les patients greffés rénaux infectés par le SARS-CoV-2 : l’expérience d’une cohorte belge

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Département de pharmacie, UCL - (SLuc) Service de microbiologie, Devresse, Arnaud, Briol, Sébastien, De Greef, Julien, Lemaitre, Florian, Boland, Lidvine, Haufroid, Vincent, Scohy, Anaïs, Yombi, Jean Cyr, Belkhir, Leïla, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Département de pharmacie, UCL - (SLuc) Service de microbiologie, Devresse, Arnaud, Briol, Sébastien, De Greef, Julien, Lemaitre, Florian, Boland, Lidvine, Haufroid, Vincent, Scohy, Anaïs, Yombi, Jean Cyr, Belkhir, Leïla, and Kanaan, Nada
Published: 2022

19. Safety and Efficiency of Molnupiravir for COVID-19 Patients with Advanced CKD

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de pharmacie, UCL - (SLuc) Département de médecine interne et services associés, Dufour, Inès, Devresse, Arnaud, Scohy, Anaïs, Briquet, Caroline, Georgery, Hélène, Delaey, Philippe, De Greef, Julien, Goffin, Eric, Labriola, Laura, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de pharmacie, UCL - (SLuc) Département de médecine interne et services associés, Dufour, Inès, Devresse, Arnaud, Scohy, Anaïs, Briquet, Caroline, Georgery, Hélène, Delaey, Philippe, De Greef, Julien, Goffin, Eric, and Labriola, Laura
Published: 2022

20. Hyperuricemia and cardiovascular risk: study in a population admitted to the cardiology department of the University Hospital of Batna

Author: Hichem Benghezel, Batna – Algérie. Faculté de médecine département de pharmacie Batna, Hadjer Bezzouza, Batna – Algérie. Faculté de médecine département de médecine, Nedjoua Alloui, Asma Cheribet, Hanane Boukrous, Rafik Bencherif, Imene Khelifi, and Batna – Algérie Laboratoire du Dr M Sadelaoud
Subjects: education.field_of_study, medicine.medical_specialty, business.industry, Population, Emergency medicine, medicine, General Medicine, Hyperuricemia, education, medicine.disease, business, University hospital
Abstract: La pathologie coronarienne est une pathologie grave posant un véritable problème de santé publique. De nombreux facteurs de risques sont à l’origine ou aggravent cette affection. L’incrimination de l’hyperuricémie comme facteur du risque cardiovasculaire reste un sujet discuté. Nous avons réalisé une étude rétrospective sur 95 prélèvements de patients collectés au niveau du service de cardiologie du centre hospitalo-universitaire de Batna Algérie, afin d’évaluer l’importance et les associations possibles entre l’hyperuricémie et les autres facteurs du risque cardiovasculaire à savoir : diabète, hypertension artérielle, insuffisance rénale, obésité, tabagisme, dyslipidémie, et son rôle directe ou non dans le syndrome coronarien aigu. L’automate cobas e411 roche diagnostics® est utilisé pour le dosage de la Troponine T ultrasensible et l'automate cobas 6000 module c501 roche diagnostics® pour le dosage de l’acide urique, du cholestérol total, du HDL direct, des triglycérides, de l’urée, de la créatinine, de l’Apo A, de l’Apo B100, de la protéine C réactive ultrasensible et l’homocystéine. L’estimation du LDL est effectuée par la formule de Friedewald. Nous avons également calculé le risque relatif cardiovasculaire (RR) par la formule de QRISK®2-2017. Nous avons estimé le débit de filtration glomérulaire selon la formule Modification of Diet in Renal Disease (MDRD) Study equation. L'analyse statistique des donnés est réalisée le logiciel SPSS statistic version 20 (test de Kruskal-Wallis, test d’indépendance du Chi-deux et Phi). Les valeurs de p inférieures à 0,05 ont été considérées comme statistiquement significatives. L’effet causal direct de l'hyperuricémie dans les maladies cardiovasculaires n’a pas pu être tranché. Néanmoins, il semble que l’hyperuricémie est fortement associée aux maladies cardiovasculaires chez la population féminine. Des associations entre l’hyperuricémie et l’élévation de la protéine C reactive (p= 0,063) (Chi-deux : 3,49, p=0,194, Phi=0,174) et la baisse de l’apo B (p=0,008) (Chi-deux : 6,23, p=0,044, Phi=0,256) confortent l’idée des effets pro inflammatoires de l’acide urique et soulèvent la question de la possibilité que des concentrations réduites de l'apo B100 soit un facteur favorisant l’hyperuricémie.
Published: 2019

21. Dynamics of spreading of SARS-CoV-2 in a Belgian hemodialysis facility: The importance of the analysis of viral strains.

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, Labriola, Laura, Ruelle, Jean, Scohy, Anaïs, Seghers, François, Perlot, Quentin, De Greef, Julien, Desmet, Christine, Romain, Cécile, Yombi, Jean Cyr, Rodriguez-Villalobos, Hector, Kabamba Mukadi, Benoît, Jadoul, Michel, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, Labriola, Laura, Ruelle, Jean, Scohy, Anaïs, Seghers, François, Perlot, Quentin, De Greef, Julien, Desmet, Christine, Romain, Cécile, Yombi, Jean Cyr, Rodriguez-Villalobos, Hector, Kabamba Mukadi, Benoît, and Jadoul, Michel
Abstract: In-center maintenance hemodialysis (HD) patients are at high risk of acquiring coronavirus disease 2019 (COVID-19) by cross-contamination inside the unit. The aim of this study was to assess retrospectively the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission during the very first pandemic phase (March-July 2020) in a cohort of in-center maintenance HD patients and in nurses the same HD facility, using a phylogenetic approach. All SARS-CoV-2 quantitative reverse-transcription polymerase chain reaction positive patients and nurses from our HD unit-respectively 10 out of 98, and 8 out of 58- and two other positive patients dialyzed in our self-care unit were included. Whole-genome viral sequencing and phylogenetic analysis supported the cluster investigation. Five positive patients were usually dialyzed in the same room and same shift before their COVID-19 diagnosis was made. Viral sequencing performed on 4/5 patients' swabs showed no phylogenetic link between their viruses. The fifth patient (whose virus could not be sequenced) was dialyzed at the end of the dialysis room and was treated by a different nurse than the one in charge of the other patients. Three nurses shared the same virus detected in both self-care patients (one of them had been transferred to our in-center facility). The epidemiologically strongly suspected intra-unit cluster could be ruled out by viral genome sequencing. The infection control policy did not allow inter-patient contamination within the HD facility, in contrast to evidence of moderate dissemination within the nursing staff and in the satellite unit. Epidemiologic data without phylogenetic confirmation might mislead the interpretation of the dynamics of viral spreading within congregate settings.
Published: 2021

22. Mortality Rate and Predictors Among Patients with COVID-19 Related Acute Respiratory Failure Requiring Mechanical Ventilation: a Retrospective Single Centre Study.

Author: UCL - (SLuc) Département de médecine interne et services associés, de Terwangne, Christophe, Sorgente, Antonio, Tortora, Redente, Cheung, Diana, Duprez, Frederic, Place, Sammy, Lechien, Jerome R, Capulzini, Lucio, Cubber, Michael De, Saussez, Sven, Taccone, Fabio Silvio, Mashayekhi, Shahram, UCL - (SLuc) Département de médecine interne et services associés, de Terwangne, Christophe, Sorgente, Antonio, Tortora, Redente, Cheung, Diana, Duprez, Frederic, Place, Sammy, Lechien, Jerome R, Capulzini, Lucio, Cubber, Michael De, Saussez, Sven, Taccone, Fabio Silvio, and Mashayekhi, Shahram
Abstract: The objective of the study was to assess mortality rates in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) who also requiring mechanical ventilation. The predictors of mortality in this cohort were analysed, and the clinical characteristics recorded. A single centre retrospective study was conducted on all COVID-19 patients admitted to the intensive care unit of the Epicura Hospital Center, Province of Hainaut, Belgium, between March 1st and April 30th 2020. Forty-nine patients were included in the study of which thirty-four were male, and fifteen were female. The mean (SD) age was 68.8 (10.6) and 69.5 (12.6) for males and females, respectively. The median time to death after the onset of symptoms was eighteen days. The median time to death, after hospital admission was nine days. By the end of the thirty days follow-up, twenty-seven patients (55%) had died, and twenty-two (45%) had survived. Non-survivors, as compared to those who survived, were similar in gender, prescribed medications, COVID-19 symptoms, with similar laboratory test results. They were significantly older (p = 0.007), with a higher co-morbidity burden (p = 0.026) and underwent significantly less tra-cheostomy (p < 0.001). In multivariable logistic regression analysis, no parameter significantly predicted mortality. This study reported a mortality rate of 55% in critically ill COVID-19 patients with ARDS who also required mechanical ventilation. The results corroborate previous findings that older and more comorbid patients represent the population at most risk of a poor outcome in this setting.
Published: 2021

23. Semi-Quantitative and Quantitative [F]FDG-PET/CT Indices for Diagnosing Large Vessel Vasculitis: A Critical Review.

Author: UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de médecine nucléaire, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Département de médecine interne et services associés, Gheysens, Olivier, Jamar, François, Glaudemans, Andor W J M, Yildiz, Halil, van der Geest, Kornelis S M, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de médecine nucléaire, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Département de médecine interne et services associés, Gheysens, Olivier, Jamar, François, Glaudemans, Andor W J M, Yildiz, Halil, and van der Geest, Kornelis S M
Abstract: To confirm the diagnosis of large vessel vasculitis (LVV) with high accuracy, one of the recommended imaging techniques is [F]Fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography ([F]FDG-PET/CT). Visual assessment of [F]FDG uptake in the arterial wall compared to liver uptake is the mainstay for diagnosing LVV in routine clinical practice. To date, there is no consensus on the preferred semi-quantitative or quantitative parameter for diagnosing LVV. The aim of this review is to critically update the knowledge on the available evidence of semi-quantitative and quantitative [F]FDG uptake parameters for diagnosing LVV and to provide future directions for methodological standardization and research.
Published: 2021

24. Non-COVID-19 In-Hospital Admission in a Large Academic Center in Belgium During the First Two Waves of the COVID-19 Pandemic.

Author: UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Yombi, Jean Cyr, Yildiz, Halil, Beguin, Claire, Habimana, Laurence, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Yombi, Jean Cyr, Yildiz, Halil, Beguin, Claire, and Habimana, Laurence
Abstract: Preliminary reports described a reduction in non-COVID admissions during the first wave of the pandemic including some of critical diseases such as cancer, myocardial and cerebral infarction. The aim of our study was to evaluate the impact of the COVID-19 pandemic on non-COVID in-hospital admissions in a large academic center in Belgium. We performed a retrospective study of non-COVID-19 in-hospital admissions during the first two waves of the COVID-19 pandemic. The average number of admissions per week in 2020 has been compared to that of the same period in 2019 and 2018. Comparisons were made first for all admissions, then by disease groups, using the classification of APRDRG, and then by diagnoses using ICD-10-CM classification. Overall in-hospital admissions were reduced by around 39% and 29% during the first and the second waves of the COVID-19 pandemic respectively compared to 2018 and 2019. No significant difference was found between the average number of admissions in the early-COVID and the pre-COVID baseline period during the two waves. The average number of admissions was significantly reduced in the peak-COVID period compared to the baseline (first wave: 332 versus 763 admissions/week, p<0.01, -57%; second wave: 496 versus 788 admissions/week, p<0.01, -37%), as well as in the late-COVID period compared to the baseline (first wave: 412 versus 763 admissions/week, p<0.01, -46%; second wave: 470 versus 788 admissions/week, p<0.01, -40%). Cancer, myocardial and cerebral infarction admissions were not statistically reduced during the the two waves of COVID pandemic compared to the pre-COVID period. Our study shows that non-COVID in-hospital admissions rates were substantially reduced during the first two waves of COVID-19 pandemic. In our study, cancer, myocardial and cerebral infarction admissions were not statistically reduced, which was not in accordance to what was described in the literature.
Published: 2021

25. Very low Immunization Rate in Kidney Transplant Recipients after one Dose of the BNT162b2 Vaccine: Beware not to Lower the Guard!

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Georgery, Hélène, Devresse, Arnaud, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Darius, Tom, Buemi, Antoine, SCOHY, Anaïs, Kabamba-Mukadi, Benoît, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Georgery, Hélène, Devresse, Arnaud, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Darius, Tom, Buemi, Antoine, SCOHY, Anaïs, Kabamba-Mukadi, Benoît, Goffin, Eric, and Kanaan, Nada
Published: 2021

26. Automated ECG diagnosis of atrial flutter by means of wavelet transform

Author: UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Service de pathologie cardiovasculaire, Brohet, Christian, Derwael, C., Fesler, R., Computers in Cardiology 1994, UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Service de pathologie cardiovasculaire, Brohet, Christian, Derwael, C., Fesler, R., and Computers in Cardiology 1994
Published: 2021

27. CHORT: an original system for cardiological database hospital reports

Author: UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - MD/CHIR - Département de chirurgie, UCL - (SLuc) Service d'anesthésiologie, Dee, D., Derwael, C., Matton, J.L., Vanbutsele, R., Brohet, Christian, De Kock, Marc, Computers in Cardiology 1994, UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - MD/CHIR - Département de chirurgie, UCL - (SLuc) Service d'anesthésiologie, Dee, D., Derwael, C., Matton, J.L., Vanbutsele, R., Brohet, Christian, De Kock, Marc, and Computers in Cardiology 1994
Published: 2021

28. Computer interpretation of the 12-lead electrocardiogram, the Frank-lead vectorcardiogram and the reconstructed vectorcardiogram

Author: UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Service de pathologie cardiovasculaire, Li, G.P., Derwael, C., Fesler, R., Brohet, Christian, Computers in Cardiology 1994, UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Service de pathologie cardiovasculaire, Li, G.P., Derwael, C., Fesler, R., Brohet, Christian, and Computers in Cardiology 1994
Published: 2021

29. Données actuelles et perspectives de la tomographie par émission de positrons en oncologie-radiothérapie

Author: UCL - (SLuc) Service de médecine nucléaire, UCL - MD/MINT - Département de médecine interne, UCL - MD/RAIM - Département de radiologie et d'imagerie médicale, UCL - (SLuc) Service de radiothérapie oncologique, UCL - (SLuc) Centre du cancer, Lonneux, Max, Sibomana, M., Pauwels, Stanislas, Grégoire, Vincent, UCL - (SLuc) Service de médecine nucléaire, UCL - MD/MINT - Département de médecine interne, UCL - MD/RAIM - Département de radiologie et d'imagerie médicale, UCL - (SLuc) Service de radiothérapie oncologique, UCL - (SLuc) Centre du cancer, Lonneux, Max, Sibomana, M., Pauwels, Stanislas, and Grégoire, Vincent
Abstract: Positron emission tomography (PET) is one of the most promising diagnostic procedures in oncology. Using the glucose analogue fluorodeoxyglucose, PET produces whole-body images and is highly sensitive for tumor diagnosis and staging. We review three particular clinical situations in which PET-FDG has proven not only its diagnostic accuracy, but also its impact on patient management, i.e., the staging of non-small cell lung cancer, diagnosis and staging of colo-rectal cancer and head and neck cancer recurrence. Image registration yields anatomo-metabolic images that could be used as additional information for the determination of radiation fields. Tracer and technical issues remain to be solved before PET can be routinely used for that purpose.
Published: 2021

30. Fungal pneumonia in kidney transplant recipients

Author: UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Département d'imagerie médicale, UCL - (SLuc) Département de biologie clinique et d'anatomie pathologique, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Wilmes, Dunja, Coche, Emmanuel, Rodriguez-Villalobos, Hector, Kanaan, Nada, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Département d'imagerie médicale, UCL - (SLuc) Département de biologie clinique et d'anatomie pathologique, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Wilmes, Dunja, Coche, Emmanuel, Rodriguez-Villalobos, Hector, and Kanaan, Nada
Published: 2021

31. T cell and Antibody Response after two Doses of the BNT162b2 Vaccine in a Belgian Cohort of Kidney Transplant Recipients

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, Devresse, Arnaud, Saad Albichr, Imane, Georgery, Hélène, Yombi, Jean Cyr, De Greef, Julien, Belkhir, Leïla, Mzougui, Samy, Scohy, Anaïs, Darius, Tom, Buemi, Antoine, Goffin, Eric, Kabamba-Mukadi, Benoît, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, Devresse, Arnaud, Saad Albichr, Imane, Georgery, Hélène, Yombi, Jean Cyr, De Greef, Julien, Belkhir, Leïla, Mzougui, Samy, Scohy, Anaïs, Darius, Tom, Buemi, Antoine, Goffin, Eric, Kabamba-Mukadi, Benoît, and Kanaan, Nada
Published: 2021

32. Techniques d'irradiation externe dans les néoplasmes thyroïdiens

Author: UCL - MD/MINT - Département de médecine interne, Ribot, J., Prignot, M., Van Dorpe, J. C., Wambersie, André, UCL - MD/MINT - Département de médecine interne, Ribot, J., Prignot, M., Van Dorpe, J. C., and Wambersie, André
Published: 2021

33. Immunogenicity of BNT162b2 SARS-CoV-2 Vaccine in a Multicenter Cohort of Nursing Home Residents Receiving Maintenance Hemodialysis

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, Labriola, Laura, Scohy, Anaïs, Van Regemorter, Elliott, Robert, Arnaud, Clerbaux, Gaëtan, Gillerot, Gaelle, Pochet, Jean-Michel, Biller, Pauline, De Schuiteneer, Manuel, Morelle, Johann, Yombi, Jean Cyr, Kabamba-Mukadi, Benoît, Rodriguez-Villalobos, Hector, Jadoul, Michel, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, Labriola, Laura, Scohy, Anaïs, Van Regemorter, Elliott, Robert, Arnaud, Clerbaux, Gaëtan, Gillerot, Gaelle, Pochet, Jean-Michel, Biller, Pauline, De Schuiteneer, Manuel, Morelle, Johann, Yombi, Jean Cyr, Kabamba-Mukadi, Benoît, Rodriguez-Villalobos, Hector, and Jadoul, Michel
Published: 2021

34. Vaccination contre le SARS-CoV-2 chez le patient greffé rénal

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, Georgery, Hélène, Devresse, Arnaud, Yombi, Jean Cyr, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, Georgery, Hélène, Devresse, Arnaud, Yombi, Jean Cyr, Goffin, Eric, and Kanaan, Nada
Abstract: Les patients greffés rénaux sont plus à risque que la population générale de développer une forme sévère - fatale - de la COVID-19 contre laquelle l’arsenal thérapeutique actuel reste limité. Malheureusement, comme chez la plupart des immunodéprimés, la réponse à un schéma standard de vaccination contre le SARS-CoV-2 chez ces patients est nettement sub-optimale. En effet, la littérature récente montre une réponse humorale de l’ordre de 50%, 1 mois après 2 doses d’un vaccin ARN messager (ARNm). En outre, les taux d’anticorps atteints sont souvent faibles à modérés. Notre expérience aux Cliniques universitaires Saint-Luc est similaire. Face à ces résultats décevants, d’autres stratégies sont nécessaires pour les patients greffés rénaux et immunodéprimés, incluant l’utilisation d’une troisième dose de vaccin et éventuellement l’utilisation d’anticorps monoclonaux. Le but de ce travail est de réaliser une revue de la littérature sur ces questions, et derapporter notre expérience locale.
Published: 2021

35. Raoultella planticola peritonitis in a patient on automated peritoneal dialysis 48 hours after sanding of a horse trail

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, Gillion, Valentine, Demoulin, Nathalie, Vandercam, Bernard, Goffin, Eric, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, Gillion, Valentine, Demoulin, Nathalie, Vandercam, Bernard, and Goffin, Eric
Published: 2021

36. Surveillance of COVID-19 in Cameroon: Implications for policymakers and the healthcare system.

Author: UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Bonnechère, Bruno, Sankoh, Osman, Samadoulougou, Sékou, Yombi, Jean Cyr, Kirakoya-Samadoulougou, Fati, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Bonnechère, Bruno, Sankoh, Osman, Samadoulougou, Sékou, Yombi, Jean Cyr, and Kirakoya-Samadoulougou, Fati
Abstract: At first less impacted than the rest of the world, African countries, including Cameroon, are also facing the spread of COVID-19. This study aimed to analyze the spread of the COVID-19 in Cameroon, one of the most affected countries in sub- Saharan Africa. We used the data from the Africa Centre for Disease Control and Prevention, reporting the number of confirmed cases and deaths, and analyzed the regularity of tests and confirmed cases and compared those numbers with neighboring countries. We tested different phenomenological models to model the early phase of the outbreak. Since the first reported cases on the 7 of March, 18,662 people have been diagnosed with COVID-19 as of the 24 of August, 186,243 tests have been performed, and 408 deaths have been recorded. New cases have been recorded only in 50% of the days since the first reported cases. There are considerable disparities in the reporting of daily cases, making it difficult to interpret these numbers and to model the evolution of the pandemic with the phenomenological models. Currently, following the finding from this study, it is challenging to predict the evolution of the pandemic and to make comparisons between countries as screening measures are so sparse. Monitoring should be performed regularly to provide a more accurate estimate of the situation and allocate healthcare resources more efficiently.
Published: 2021

37. Hydroxychloroquine in the post-COVID-19 era: will this pandemic upset decades of clinical practice?

Author: UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Pothen, Lucie, Yildiz, Halil, Samnick, Mathilde Mbouck, Yombi, Jean Cyr, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Pothen, Lucie, Yildiz, Halil, Samnick, Mathilde Mbouck, and Yombi, Jean Cyr
Abstract: In the early stage of the COVID-19 pandemic, Belgian health authorities endorsed the interim guidelines for the treatment of COVID-19 pneumonia: hydroxychloroquine (HCQ) recommended for treatment of hospitalized patients with moderate to severe disease. As a growing number of patients were admitted, inevitably, our internal medicine team questioned the efficacy and safety of HCQ, especially with regard to cardiac side effects. In parallel with our concerns, data regarding the safety and efficacy of HCQ were published, with discordant results and debate in the medical community. Media coverage of the possible risks and benefits of HCQ use in COVID-19 also caused confusion amongst the public. In this Perspectives in Rheumatology article, we review the use and safety of HCQ in autoimmune disease and its putative efficacy and toxicity in COVID-19. Finally, we share our concern about the future of this widely used and inexpensive drug after the COVID-19 pandemic has passed.
Published: 2021

38. Actinomycosis associated with a permanently implanted duodenal over-the-scope clip.

Author: UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de gastro-entérologie, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, Leal, Carina, Dano, Helene, Belkhir, Leila, Deprez, Pierre H, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de gastro-entérologie, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, Leal, Carina, Dano, Helene, Belkhir, Leila, and Deprez, Pierre H
Abstract: No abstract available
Published: 2021

39. Predictive accuracy of COVID-19 WHO severity classification and comparison with a Bayesian-method-based severity score (EPI-SCORE)

Author: Epicura Centre Hospitalier - Département de médecine interne, de Terwangne, Christophe, Kapuczinski, Abeline, Szklarzewska, Sylwia, Laouni, Jabber, Thieffry, Olivier, Bouillon, Vincent, Scholtens, Joyce, Mastroianni, François, Vanwielendaele, Maxime, Jouffe, Lionel, Lechien, Jerome R, Place, Sammy, Mashayekhi, Shahram, Saussez, Sven, Sorgente, Antonio, Epicura Centre Hospitalier - Département de médecine interne, de Terwangne, Christophe, Kapuczinski, Abeline, Szklarzewska, Sylwia, Laouni, Jabber, Thieffry, Olivier, Bouillon, Vincent, Scholtens, Joyce, Mastroianni, François, Vanwielendaele, Maxime, Jouffe, Lionel, Lechien, Jerome R, Place, Sammy, Mashayekhi, Shahram, Saussez, Sven, and Sorgente, Antonio
Published: 2021

40. Administration de vaccins par les infirmiers, sages-femmes et pharmaciens d’officine Une étude multinationale

Author: UCL - SSS/IRSS - Institut de recherche santé et société, UCL - SSS/LDRI - Louvain Drug Research Institute, Université de Liège - Département de Médecine Générale, Unité de Recherche Soins Primaires et Santé, UCL - (MGD) Département de pharmacie, Scholtès, Béatrice, Valentin, Stéphanie, Spinewine, Anne, Van Durme, Thérèse, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - SSS/LDRI - Louvain Drug Research Institute, Université de Liège - Département de Médecine Générale, Unité de Recherche Soins Primaires et Santé, UCL - (MGD) Département de pharmacie, Scholtès, Béatrice, Valentin, Stéphanie, Spinewine, Anne, and Van Durme, Thérèse
Abstract: Cette étude offre un aperçu de la pratique actuelle de l'administration des vaccins dans les États voisins ou comparables à la Belgique. Nous avons décrit un panorama hétérogène de systèmes de santé qui gèrent l'administration du vaccin de différentes manières. La littérature sur le thème du transfert des tâches vers l'administration de vaccins sans médecin suggère qu'il y a des pistes à explorer en termes de possibilités de communication et d'accessibilité pour les patients. Les informations que nous avons recueillies indiquent qu'il existe de nombreuses possibilités d'apprentissage trans-frontaliers dans ce domaine
Published: 2020

41. Clinical and microbiological profiles of aggressive and chronic periodontitis in Congolese patients: A cross-sectional study

Author: UCL - (SLuc) Département de médecine dentaire et stomatologie, UCL - (SLuc) Service de parodontologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, Kalala-Kazadi, Em, Toma, Selena, Lasserre, jérôme, Nyimi-Bushabu, Fidèle, Ntumba-Mulumba, Hubert, Brecx, Michel, UCL - (SLuc) Département de médecine dentaire et stomatologie, UCL - (SLuc) Service de parodontologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, Kalala-Kazadi, Em, Toma, Selena, Lasserre, jérôme, Nyimi-Bushabu, Fidèle, Ntumba-Mulumba, Hubert, and Brecx, Michel
Abstract: Chronic and aggressive periodontitis were the main forms of periodontitis according to the 1999 classification of periodontal diseases and conditions. Their profile in Congolese patients is still undescribed. Aim: The aim of this study was to compare the profile of chronic periodontitis (ChP) with that of aggressive periodontitis (AgP) in Congolese patients. Materials and Methods: Thirty-two patients with ChP and 20 with AgP who consulted the dental services at any of the four medical centers in Kinshasa, from April 2017 to April 2018, were enrolled in the cross-sectional study. All patients underwent a full mouth examination, including assessment of the probing pocket depth and clinical attachment level at six sites per tooth. Microbial samples were collected in the deepest pocket in the maxilla and the deepest pocket in the mandible. A deoxyribonucleic acid (DNA) analysis was performed using DNA strip technology. Fisher exact test, the chi-square test, the t test, and the Mann-Whitney test were used for the statistical analysis. Results: Patients with AgP were significantly younger than those with ChP (P 0.001). There was no significant difference in the prevalence of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, or Prevotella intermedia between the AgP and ChP groups (P 0.05). Aggregatibacter actinomycetemcomitans was detected in 10% of cases in the AgP group and in none of those in the ChP group (P = 0.143). Conclusion: This study shows that the clinical profiles of ChP and AgP are similar in Congolese patients. There were no microbiological differences between these two forms of periodontitis. © 2020 Journal of International Society of Preventive and Community Dentistry | Published by Wolters Kluwer - Medknow.
Published: 2020

42. [Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report].

Author: UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Département de biologie clinique et d'anatomie pathologique, UCL - (SLuc) Service d'anatomie pathologique, Vandemergel, X, Lefebvre, M, Focant, I, Marot, L, Ilisei, D, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Département de biologie clinique et d'anatomie pathologique, UCL - (SLuc) Service d'anatomie pathologique, Vandemergel, X, Lefebvre, M, Focant, I, Marot, L, and Ilisei, D
Abstract: Pyoderma gangrenosum is an uncommon neutrophilic dermatosis that presents as an inflammatory and ulcerative disorder of the skin. This entity is associated with systemic diseases and autoimmune diseases but exceptionally with autoimmune hepatitis. We report the case of a 40 year-old woman diagnosed with type 1 autoimmune hepatitis 12 years earlier and admitted for the appearance of an ulcerative lesion in the left leg. Histology confirmed pyoderma gangrenosum.
Published: 2019

43. Classification of the Immune Composition in the Tumor Infiltrate.

Author: UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Département de médecine interne et services associés, Brusa, Davide, Balligand, Jean-Luc, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Département de médecine interne et services associés, Brusa, Davide, and Balligand, Jean-Luc
Abstract: Flow cytometry is one of the most suitable techniques for analyzing and classifying different cell suspensions derived from blood or others compartments. The characterization of all different cellular subtypes is made with different antibodies that detect surface or intracytoplasmic antigens. Here we describe the technique to thoroughly characterize immune cells from tumor infiltrates and proceed to isolation using single-cell sorting.
Published: 2019

44. Maladie de Still de l’adulte : cause rare de fièvre prolongée

Author: UCL - (SLuc) Département de médecine interne et services associés, El-Mourad omar, Roodhans Fabien, Huyge Valérie, UCL - (SLuc) Département de médecine interne et services associés, El-Mourad omar, Roodhans Fabien, and Huyge Valérie
Abstract: La maladie de Still de l’adulte est une cause rare de fièvre prolongée d’étiologie indéterminée. Sa symptomatologie clinique et ses manifestations biologiques sont polymorphes et peu spécifiques. Nous soulignerons l’intérêt du dosage de la ferritinémie couplée à la ferritine glycosylée. Le diagnostic de maladie de Still repose sur les critères de Yamaguchi : 3 critères majeurs présents (fièvre élevée depuis plus d’une semaine, hyperleucocytose neutrophile majeure, arthralgies diffuses) et 3 critères mineurs (augmentation des enzymes hépatiques sans évidence médicamenteuse ou toxique, adénopathies identifiées au Pet-scan et négativité des anticorps antinucléaires et des facteurs rhumatoïdes). La physiopathologie reste mal connue et le traitement s’appuie encore principalement sur les glucocorticoïdes par voie systémique. Nous discutons enfin l’intérêt des biothérapies, en particulier des antagonistes spécifiques du recepteur de l’IL-6.
Published: 2019

45. Artérite giganto-cellulaire : discussion clinique, paraclinique et thérapeutique

Author: UCL - (SLuc) Département de médecine interne et services associés, Omar El-Mourad, Roodhans Fabien, Huyge Valérie, Guetcho Bruno, UCL - (SLuc) Département de médecine interne et services associés, Omar El-Mourad, Roodhans Fabien, Huyge Valérie, and Guetcho Bruno
Abstract: La maladie de Horton ou artérite giganto-cellulaire est une artérite qui affecte essentiellement les vaisseaux de grands calibres. Elle touche ainsi les territoires dépendants des branches de la carotide externe mais peut aussi atteindre l’oeil, le système nerveux central, le tube digestif, le système respiratoire, le système artériel des membres inférieurs, le coeur. Le diagnostic de confirmation s’appuie toujours sur la biopsie de l’artère temporale qui n’est cependant pas positive dans tous les cas. Le Pet-Scan prend une place de plus en plus importante dans l’arbre diagnostic en montrant une hyperfixation métabolique des grands et des moyens vaisseaux. Le traitement repose toujours sur les glucocorticoïdes par voie systémique. Toutefois, nous signalons la place progressivement croissante de biothérapies dont principalement les antagonistes spécifiques du récepteur de l’IL-6.
Published: 2019

46. Innovations en infectiologie en 2018 : ce que doit savoir le médecin généraliste

Author: UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Yombi, Jean Cyr, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, and Yombi, Jean Cyr
Abstract: Dans divers domaines de la médecine, plusieurs innovations et/ou nouveautés ont été réalisées en 2018 et l’infectiologie n’échappe pas à la règle (1). Dans cet article, nous avons sélectionné les informations et nouveautés pertinentes que le médecin généraliste doit connaître.
Published: 2019

47. Prise en charge de la cirrhose en Médecine générale

Author: UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Paternostre, Sophie, Yombi, Jean Cyr, Starkel, Peter, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Paternostre, Sophie, Yombi, Jean Cyr, and Starkel, Peter
Abstract: La cirrhose est une pathologie couramment rencontrée en médecine générale. Les étiologies peuvent être variées et sont essentiellement d’origine toxique (alcool…), d’origine métabolique (stéatose non alcoolique : NASH...) ou d’origine infectieuse (Hépatites B et C...). L’évaluation initiale peut être faite à l’aide d’une prise de sang et d’une échographie abdominale. La confirmation du diagnostic fera appel à des mesures non-invasives de la fibrose soit via des marqueurs biologiques (Fibrotest®) soit par élastographie impulsionnelle (Fibroscan®). La réalisation d’une biopsie hépatique n’est que rarement requise. La prise en charge thérapeutique passe par le traitement des étiologies de la cirrhose et la prise en charge de ses complications. L’arrêt complet de l’alcool, la perte de poids et le contrôle des facteurs du syndrome métabolique en sont des exemples. En cas de cirrhose avérée, un suivi par échographie abdominale et un dosage d’alpha-foeto-protéine tous les 6 mois doit être réalisé afin de dépister un éventuel hépatocarcinome. Un contrôle de gastroscopie est également recommandé tout le 2-3 ans pour évaluer la présence de varices œsophagiennes.
Published: 2019

48. Design and rationale of the non-interventional, edoxaban treatment in routiNe clinical prActice in patients with venous ThromboEmbolism in Europe (ETNA-VTE-Europe) study

Author: UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de médecine interne générale, Cohen, Alexander T., Ay, Cihan, Hainaut, Philippe, Décousus, Hervé, Hoffmann, Ulrich, Gaine, Sean, Coppens, Michiel, da Silva, Pedro Marques, Jiménez, David, Amann-Vesti, Beatrice, Brüggenjürgen, Bernd, Levy, Pierre, Bastida, Julio Lopez, Vicaut, Eric, Laeis, Petra, Fronk, Eva-Maria, Zierhut, Wolfgang, Malzer, Thomas, Bramlage, Peter, Agnelli, Giancarlo, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de médecine interne générale, Cohen, Alexander T., Ay, Cihan, Hainaut, Philippe, Décousus, Hervé, Hoffmann, Ulrich, Gaine, Sean, Coppens, Michiel, da Silva, Pedro Marques, Jiménez, David, Amann-Vesti, Beatrice, Brüggenjürgen, Bernd, Levy, Pierre, Bastida, Julio Lopez, Vicaut, Eric, Laeis, Petra, Fronk, Eva-Maria, Zierhut, Wolfgang, Malzer, Thomas, Bramlage, Peter, and Agnelli, Giancarlo
Abstract: Background:Venous thromboembolism (VTE, including deep vein thrombosis [DVT] and pulmonary embolism [PE])has an annual incidence rate of 104–183 per 100,000 person-years. After a VTE episode, the two-year recurrence rate isabout 17%. Consequently, effective and safe anticoagulation is paramount. Edoxaban is a direct oral anticoagulant(DOAC) approved VTE treatment. Current safety and efficacy data are derived from clinical trials, and information abouttreatment durations beyond 12 months are not available.Methods:ETNA-VTE-Europe is an 18-month prospective, single-arm, non-interventional, multinational post-authorisationsafety study. Approximately 310 sites across eight European countries (Austria,Belgium, Germany, Ireland, Italy, theNetherlands, Switzerland and the United Kingdom) will participate in the study, with the intention to represent theregional distributions of centres, healthcare settings and specialties.An estimated cohort of 2700 patients will berecruited, the only enrolment criteriabeing acute symptomatic VTE, no participation in an interventional study, andtreating physician decision to prescribe edoxaban independently from the registry. Data from patient medical recordsand/or telephone interviews will be collected at baseline, 1, 3, 6, 12 and 18 months. The primary objective is to evaluatethe18-monthrateofsymptomaticVTErecurrenceinpatientswithVTEtreatedwithedoxabanoutsideaclinicaltrial.Theco-primary objective is to evaluate the real-world rates ofbleeding and adverse drug reactions. Secondary outcomesinclude rates of other patient-relevant safety events, adherence to and discontinuation of edoxaban. Furthermore, 12-month ETNA-VTE-Europe data will be considered in the contextof those for patients receiving different anticoagulants inthe PREFER in VTE registry and Hokusai-VTE clinical trial
Published: 2018

49. Correction to: Design and rationale of the non-interventional, edoxaban treatment in routiNe clinical prActice in patients with venous ThromboEmbolism in Europe (ETNA-VTE-Europe) study.

Author: UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Département de médecine interne et services associés, Cohen, Alexander T, Ay, Cihan, Hainaut, Philippe, Décousus, Hervé, Hoffmann, Ulrich, Gaine, Sean, Coppens, Michiel, da Silva, Pedro Marques, Jimenez, David, Amann-Vesti, Beatrice, Brüggenjürgen, Bernd, Levy, Pierre, Bastida, Julio Lopez, Vicaut, Eric, Laeis, Petra, Fronk, Eva-Maria, Zierhut, Wolfgang, Malzer, Thomas, Bramlage, Peter, Agnelli, Giancarlo, ETNA-VTE-Europe investigators, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Département de médecine interne et services associés, Cohen, Alexander T, Ay, Cihan, Hainaut, Philippe, Décousus, Hervé, Hoffmann, Ulrich, Gaine, Sean, Coppens, Michiel, da Silva, Pedro Marques, Jimenez, David, Amann-Vesti, Beatrice, Brüggenjürgen, Bernd, Levy, Pierre, Bastida, Julio Lopez, Vicaut, Eric, Laeis, Petra, Fronk, Eva-Maria, Zierhut, Wolfgang, Malzer, Thomas, Bramlage, Peter, Agnelli, Giancarlo, and ETNA-VTE-Europe investigators
Abstract: [This corrects the article DOI: 10.1186/s12959-018-0163-7.].
Published: 2018

50. Studying the Role of AMPK in Cardiac Hypertrophy and Protein Synthesis.

Author: UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologies cardiovasculaires intensives, UCL - (SLuc) Département cardiovasculaire, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Département de médecine interne et services associés, Mailleux, Florence, Beauloye, Christophe, Balligand, Jean-Luc, Horman, Sandrine, Bertrand, Luc, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologies cardiovasculaires intensives, UCL - (SLuc) Département cardiovasculaire, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Département de médecine interne et services associés, Mailleux, Florence, Beauloye, Christophe, Balligand, Jean-Luc, Horman, Sandrine, and Bertrand, Luc
Abstract: Pathological cardiac hypertrophy, which is a compensatory mechanism established to maintain cardiac function in response to neurohormonal or mechanical stresses, becomes maladaptive with time and frequently leads to heart failure. AMP-activated protein kinase (AMPK) has been extensively described in the literature to act as a break in cardiac hypertrophy development. Its anti-hypertrophic action mostly correlates with the inhibition of several important players of cardiac hypertrophy including protein synthesis and pro-hypertrophic gene expression pathways involving the transcription factor nuclear factor of activated T cells (NFAT) and the mitogen-activated protein kinases ERK1/2. In this chapter, we describe methodologies designed to evaluate cardiomyocyte hypertrophy and its major molecular mechanisms in response to AMPK activation. Two different compounds, AICAr and the biguanide phenformin, were used to promote AMPK activation.
Published: 2018

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