7 results on '"Dérimay, François"'
Search Results
2. One year results of coronary bifurcation revascularization with the re-POT provisional sequential technique. The CABRIOLET registry.
- Author
-
Dérimay, François, Aminian, Adel, Lattuca, Benoit, Souteyrand, Géraud, Maillard, Luc, Alvain, Sean, Cayla, Guillaume, Motreff, Pascal, Bochaton, Thomas, Hayek, Ahmad, Rioufol, Gilles, and Finet, Gérard
- Abstract
Re -POT (proximal optimization technique (POT)) is a simple provisional sequential technique for percutaneous coronary bifurcation revascularization with better arterial geometry respect compared to classical techniques. Re -POT has demonstrated excellent mechanical and short-term clinical results. The multicenter CABRIOLET registry (NCT03550196) evaluate the long-term clinical benefit of the re-POT sequence in non-selected patients. All consecutive patients presenting a coronary bifurcation lesion for which provisional stenting was indicated were included in 5 european centers. Re -POT strategy was systematically attempted. The primary endpoint was target lesion failure (TLF), comprising cardiac death, myocardial infarction, stent thrombosis and target lesion revascularization (TLR) at 12 months' follow-up. The secondary endpoints were the individual components of the primary endpoint, all-cause death, target vessel failure (TVF) and target vessel revascularization (TVR). Complex bifurcation was defined as Medina 0.1.1 or 1.1.1. A total of 500 patients aged 67.7 ± 11.7 years, 78.4% male, were included from 2015 to 2019, 174 of whom (34.8%) were considered having complex bifurcation lesions. Bifurcations involved the left main in 35.2% of cases. The full re-POT sequence was systematically performed in all cases. At 1 year, TLF was 2.0% (1.7% in complex vs. 2.1% in non-complex bifurcation; p = NS), and TLR was 1.6%, (1.1% vs. 1.8% respectively; p = NS). TVF and TVR rates were 3.2% and 2.8%. On multivariate analysis, only multivessel disease was predictive of TLF at 1 year (OR = 1.66 (1.09–2.53), p = 0.02). In this large prospective all-comer registry, provisional stenting with re-POT technique appeared safe and effective at 1 year, without anatomical bifurcation restriction. • Re-POT demonstrated a better respect of coronary bifurcation physiology than KBI. • Sequential technique re-POT is recommended by the European Bifurcation Club. • CABRIOLET is the first clinical evaluation of the long-term benefit of the re-POT. • Re-POT demonstrated excellent clinical results at 1 year, only 2% of TLF. • Re-POT is an efficient technique for bifurcation provisional stenting. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease.
- Author
-
Rioufol, Gilles, Dérimay, François, Roubille, François, Perret, Thibault, Motreff, Pascal, Angoulvant, Denis, Cottin, Yves, Meunier, Ludovic, Cetran, Laura, Cayla, Guillaume, Harbaoui, Brahim, Wiedemann, Jean-Yves, Van Belle, Éric, Pouillot, Christophe, Noirclerc, Nathalie, Morelle, Jean-François, Soto, François-Xavier, Caussin, Christophe, Bertrand, Bernard, and Lefèvre, Thierry
- Subjects
- *
CORONARY artery disease , *PERCUTANEOUS coronary intervention , *MORTALITY , *TRANSPLANTATION of organs, tissues, etc. , *CORONARY arteries , *RESEARCH , *CORONARY artery bypass , *CORONARY artery stenosis , *PREDICTIVE tests , *RESEARCH methodology , *MEDICAL care , *SURGICAL complications , *MEDICAL cooperation , *EVALUATION research , *CARDIOVASCULAR system , *CORONARY circulation , *RISK assessment , *CORONARY angiography , *COMPARATIVE studies , *RANDOMIZED controlled trials - Abstract
Background: There is limited evidence that fractional flow reserve (FFR) is effective in guiding therapeutic strategy in multivessel coronary artery disease (CAD) beyond prespecified percutaneous coronary intervention or coronary graft surgery candidates.Objectives: The FUTURE (FUnctional Testing Underlying coronary REvascularization) trial aimed to evaluate whether a treatment strategy based on FFR was superior to a traditional strategy without FFR in the treatment of multivessel CAD.Methods: The FUTURE trial is a prospective, randomized, open-label superiority trial. Multivessel CAD candidates were randomly assigned (1:1) to treatment strategy based on FFR in all stenotic (≥50%) coronary arteries or to a traditional strategy without FFR. In the FFR group, revascularization (percutaneous coronary intervention or surgery) was indicated for FFR ≤0.80 lesions. The primary endpoint was a composite of major adverse cardiac or cerebrovascular events at 1 year.Results: The trial was stopped prematurely by the data safety and monitoring board after a safety analysis and 927 patients were enrolled. At 1-year follow-up, by intention to treat, there were no significant differences in major adverse cardiac or cerebrovascular events rates between groups (14.6% in the FFR group vs 14.4% in the control group; hazard ratio: 0.97; 95% confidence interval: 0.69-1.36; P = 0.85). The difference in all-cause mortality was nonsignificant, 3.7% in the FFR group versus 1.5% in the control group (hazard ratio: 2.34; 95% confidence interval: 0.97-5.18; P = 0.06), and this was confirmed with a 24 months' extended follow-up. FFR significantly reduced the proportion of revascularized patients, with more patients referred to exclusively medical treatment (P = 0.02).Conclusions: In patients with multivessel CAD, we did not find evidence that an FFR-guided treatment strategy reduced the risk of ischemic cardiovascular events or death at 1-year follow-up. (Functional Testing Underlying Coronary Revascularisation; NCT01881555). [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
4. Sequential coronary bifurcation revascularization with the Xposition S™ self-apposing stent: a comparative fractal bench study.
- Author
-
Dérimay, François, Maillard, Luc, Rioufol, Gilles, Souteyrand, Géraud, Aminian, Adel, Veziers, Joëlle, Guerin, Patrice, and Finet, Gérard
- Subjects
- *
MATHEMATICAL optimization , *BENCHES - Abstract
Coronary bifurcation revascularization needs to take account of the diameter differential between vessels and to limit side-branch obstruction (SBO). The self-apposing properties of the Xposition S™ stent (STENTYS, France) seem interesting in this regard. The present experimental fractal bench study determined the best provisional stenting technique using Xposition S™. Three sequential strategies were compared (n = 5/group): implantation alone, side-branch inflation (SBI), and re-POT (initial proximal optimization technique (POT) + SBI + final POT). 2D- and 3D-OCT analyses and micro-CT scan were performed to quantify the main mechanical results at each step. Of the three groups, SBI and re-POT provided better final results than implantation alone in terms of residual SBO (respectively, 24.6 ± 5.6% and 24.8 ± 5.0% vs. 46.5 ± 10.3%, p < 0.05) and malapposition (respectively, 0.9 ± 0.6% and 0.8 ± 0.4% vs. 3.8 ± 1.9%, p < 0.05). Unlike SBI, the two POTs of the re-POT sequence did not improve the final result. SBI, alone or as part of re-POT, systematically led to one connector breakage, whereas implantation alone maintained complete stent integrity (p < 0.05). In Xposition S™ implantation, SBI should be systematic, but not post-dilatation specifically dedicated to bifurcation stenting (i.e., POTs). However, global post-dilatation is still mandatory to prevent stent underexpansion due to untreated stenosis. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
5. Optimal balloon positioning for the proximal optimization technique? An experimental bench study.
- Author
-
Dérimay, François, Rioufol, Gilles, Nishi, Takeshi, Kobayashi, Yuhei, Fearon, William F., Veziers, Joëlle, Guérin, Patrice, and Finet, Gérard
- Subjects
- *
MATHEMATICAL optimization , *BALLOONS , *BENCHES - Abstract
The proximal optimization technique (POT) in coronary bifurcation stenting improves apposition and side-branch obstruction. The POT balloon should be positioned with the distal radio-opaque marker at the carina cut plane. However, the real impact of positioning remains unknown. Synergy ™ stents (Boston Scientific, USA) were implanted on left-main fractal bench models. Initial POT was performed in 3 positions according to distal shoulder position (loss of balloon parallelism) relative to the carina cut plane (n = 5/group): i) "proximal", 1 mm before carina; ii) "medium", just at carina; iii) "distal", 1 mm after carina. Results were quantified on 2D- and 3D-OCT. Compared to implantation, initial POT improved malapposition in all positions ("proximal": 61.5 ± 1.4% vs. 5.1 ± 2.7%; "medium": 60.2 ± 2.4% vs. 1.3 ± 0.6%; "distal": 60.5 ± 2.9% vs. 1.1 ± 1.8%, p < 0.05). However, residual malapposition was greater in "proximal" position (p < 0.05). "Proximal", unlike "medium" or "distal" POT, also failed to improve side-branch obstruction. Conversely, "distal" POT significantly overstretched the main-branch ostium, with stent/artery ratio 1.22 ± 0.04 vs. 1.11 ± 0.07 for "medium" POT (p < 0.05). Shoulder positioning is essential to optimize the mechanical benefit of POT without main-branch overstretch (too distal position). Experimentally, the best position is just at the carina cut plane ("medium"). • POT balloon positioning is crucial in optimizing mechanical benefit in terms of apposition and side-branch obstruction. • The POT balloon should be positioned so that distal loss of parallelism occurs just at the carina cut plane. • Achieving this requires perfect knowledge of the specific balloon characteristics. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
6. Benefits of final proximal optimization technique (POT) in provisional stenting.
- Author
-
Dérimay, François, Rioufol, Gilles, Cellier, Guillaume, Souteyrand, Géraud, and Finet, Gérard
- Subjects
- *
CORONARY disease , *HEART disease diagnosis , *SURGICAL stents , *CARDIAC surgery ,ARTERIAL abnormalities - Abstract
Abstract Aims Initial proximal optimization technique (POT) in provisional stenting improves global malapposition, side-branch (SB) obstruction (SBO) and conservation of arterial circularity. The specific mechanical effects of a final POT sequence concluding the main provisional stenting techniques, on the other hand, are unknown. Methods and results Synergy™ stents were implanted on fractal coronary bifurcation bench models using the main provisional stenting techniques (n = 5 per group): kissing-balloon inflation (KBI), snuggle, and rePOT (initial POT + SB inflation + final POT). Final results were quantified on 2D and 3D OCT before and after final POT. Whichever the technique, final POT significantly decreased global malapposition (from 7.6 ± 5.3% to 2.2 ± 2.5%, p < 0.05) and proximal elliptic deformation (from 1.15 ± 0.07 to 1.09 ± 0.04, p < 0.05), without impact on SBO (from 11.5 ± 9.6% to 12.9 ± 10.6%, NS). However, final POT failed to completely correct the elliptic deformation induced by balloon juxtaposition during the KBI and snuggle techniques, with final elliptic ratios of 1.11 ± 0.03 and 1.11 ± 0.04 respectively, significantly higher than with the complete rePOT sequence: 1.05 ± 0.02 (p < 0.05). Conclusions Like initial POT, final POT is recommended whatever the provisional stenting technique used. However, final POT fails to completely correct all proximal elliptic deformation associated with "kissing-like" techniques, in contrast to results with the rePOT sequence. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
7. Letter by Dérimay et al. regarding the article, "A randomized trial comparing two stent sizing strategies in coronary bifurcation treatment with bioresorbable vascular scaffolds - The Absorb Bifurcation Coronary (ABC) trial" by Rampat et al.
- Author
-
Dérimay, François, Rioufol, Gilles, and Finet, Gérard
- Subjects
- *
INTRAVASCULAR ultrasonography - Published
- 2019
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.