41 results on '"Dündar, İsmail"'
Search Results
2. Clinical and Laboratory Characteristics of MODY Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship.
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Özsu, Elif, Çetinkaya, Semra, Bolu, Semih, Hatipoğlu, Nihal, Erdeve, Şenay Savaş, Evliyaoğlu, Olcay, Baş, Firdevs, Çayır, Atilla, Dündar, İsmail, Akbaş, Emine Demet, Uçaktürk, Seyid Ahmet, Berberoğlu, Merih, Şıklar, Zeynep, Özalkak, Şervan, Şahin, Nursel Muratoğlu, Keskin, Melikşah, Şiraz, Ülkü Gül, Turan, Hande, Öztürk, Ayşe Pınar, and Mengen, Eda
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METFORMIN ,MATURITY onset diabetes of the young ,TURKS ,HYPOGLYCEMIC agents ,ORAL drug administration ,DIABETIC acidosis ,DESCRIPTIVE statistics ,GENETIC variation ,HYPERGLYCEMIA ,GENETIC mutation ,INSULIN secretagogues ,DATA analysis software ,PHENOTYPES ,GENOTYPES ,GENETIC testing ,OBESITY ,CHILDREN - Abstract
Objective: Maturity onset diabetes of the young (MODY) occurs due to mutations in genes involved in pancreatic beta cell function and insulin secretion, has heterogeneous clinical and laboratory features, and account for 1-5% of all diabetes cases. The prevalence and distribution of MODY subtypes vary between countries. The aim of this study was to evaluate the clinical and laboratory characteristics, mutation distribution, and phenotype-genotype relationship in a large case series of pediatric Turkish patients genetically diagnosed with MODY. Methods: MODY cases from 14 different pediatric endocrinology departments were included. Diagnosis, treatment, follow-up data, and results of genetic analysis were evaluated. Results: A total of 224 patients were included, of whom 101 (45%) were female, and the mean age at diagnosis was 9.4±4.1 years. Gene variant distribution was: 146 (65%) GCK; 43 (19%) HNF1A; 8 (3.6%) HNF4A, 8 (3.6%) KLF11 and 7 (3.1%) HNF1B. The remaining 12 variants were: PDX (n=1), NEUROD1 (n=3), CEL (n=1), INS (n=3), ABCC8 (n= 3) and KJNC11 (n=1). Of the cases, 197 (87.9%) were diagnosed with incidental hyperglycemia, 16 with ketosis (7%) and 7 (3%) with diabetic ketoacidosis (DKA), while 30% presented with classical symptoms of diabetes. Two-hundred (89%) had a family history of diabetes. Anti-GAD antibody was detected in 13 cases, anti-islet antibody in eight and anti-insulin antibody in four. Obesity was present in 16. Distribution of therapy was: 158 (71%) diet only; 23 (11%) intensive insulin treatment; 17 (7.6%) sulfonylureas; 10 (4.5%) metformin; and 6 (2.7%) insulin and oral anti-diabetic treatment. Conclusion: This was the largest genetically diagnosed series from Turkey. The most common gene variants were GCK and HNF1A with much lower proportions for other MODY types. Hyperglycemia was the most common presenting symptom while 11% of patients had diabetes-associated autoantibodies and 7% were obese. The majority of patients received dietary management only. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Nutritional rickets in Turkish and refugee children aged 0-2: an increasing problem despite vitamin D prophylaxis
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Dündar, İsmail, primary and Büyükavcı, Mehmet Akif, additional
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- 2023
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4. Ana sınıfında veya ilkokulda okuyan tip 1 diabetes mellitus tanılı çocukların okulda hastalık yönetimi ile ilgili yaşadıkları sorunlar
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ÇİFTCİ, Nurdan, primary, ÇAMTOSUN, Emine, additional, DÜNDAR, İsmail, additional, and AKINCI, Ayşehan, additional
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- 2023
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5. Clinical Characteristics and Genetic Analyses of Patients with Idiopathic Hypogonadotropic Hypogonadism
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Çiftci, Nurdan, primary, Akıncı, Ayşehan, additional, Akbulut, Ekrem, additional, Çamtosun, Emine, additional, Dündar, İsmail, additional, Doğan, Mustafa, additional, and Kayaş, Leman, additional
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- 2023
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6. Doğumsal hipotiroidi Ulusal Tarama Programından bir kesit; son 6 yıl değerlendirimi, tiroksin dozu geçici/kalıcı doğumsal hipotiroidi öngörümünde yol gösterici olabilir
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Darcan, Şükran, Demir, Korcan, Evliyaoğlu, Saadet Olcay, Erginöz, Ethem, Orbak, Zerrin, Keskin, Mehmet, Berberoğlu, Merih, Şıklar, Zeynep, Parlak, Mesut, Hatipoğlu, Nihal, Esen, İhsan, Eren, Erdal, Darendeliler, Fatma Feyza, Eklioğlu, Beray Selver, Turan, Hande, Singin, Berna, Dündar, İsmail, Buhur Pirimoğlu, Meltem, Tercan, Ummahan, Sayılı, Uğurcan, and Anık, Ahmet
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- 2022
7. Type 1 Diabetes Incidence Trends in a Cohort of Turkish Children and Youth.
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Dündar, İsmail, Akıncı, Ayşehan, Çamtosun, Emine, Kayaş, Leman, Çiftçi, Nurdan, and Özçetin, Erdener
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PUBLIC health surveillance , *CONFIDENCE intervals , *TIME , *TYPE 1 diabetes , *PEDIATRICS , *DISEASE incidence , *SEX distribution , *DESCRIPTIVE statistics , *DATA analysis software , *LONGITUDINAL method , *POISSON distribution , *CHILDREN , *ADOLESCENCE - Abstract
Objective: The aim was to analyze the incidence trend and annual average incidence change of type 1 diabetes (T1DM) in the population <18 years of age in Malatya province. Materials and Methods: Medical files of patients followed up with T1DM in pediatric endocrinology clinics were reviewed. The data for the child census was taken from the Turkish Statistical Institute (TUIK), and T1DM incidence was analyzed according to the calendar year, gender, and age groups. Recently diagnosed T1DM patients per 100 000 children per year were calculated. In addition, the trend in annual incidence change over the period 2007-2019 was analyzed. Results: The mean incidence of T1DM during the 13 years was 13.1/105 child years (13.8/105 child years for girls and 12.4/105 child years for boys). During the 13-year follow-up period, a significant increasing trend in the incidence of T1DM was detected. The average annual percent change (AAPC) was 8.3%. According to age groups, the average AAPC was 8.1% between 0 and 4 years old, 9.4% between 5 and 9 years old, 12.1% between 10 and 14 years old, and 30.1% between 15 and 17 years old. Conclusion: The incidence of T1DM in children under 18 years of age in Malatya, one of the largest cities in the Eastern Anatolia region of Turkey, was determined as 13.1/105 child years in the last 13 years and the average annual increase rate was 8.3%. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Assessment of Side Effects of COVID-19 Vaccination in Child Patients Diagnosed with Type-1 Diabetes Mellitus.
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ÇİFTCİ, Nurdan, ÇAMTOSUN, Emine, DÜNDAR, İsmail, YAĞIN, Fatma Hilal, and AKINCI, Ayşehan
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VACCINATION complications ,VACCINATION of children ,CHILD patients ,DIABETES ,JUVENILE diseases - Abstract
Copyright of Firat Tip Dergisi is the property of Firat University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
9. Chronic Disease Management of Children Followed with Type 1 Diabetes Mellitus.
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Baysal, Şenay Güven, Çiftci, Nurdan, Dündar, İsmail, Büyükavcı, Mehmet Akif, Yağın, Fatma Hilal, Çamtosun, Emine, Doğan, Derya Gümüş, and Akıncı, Ayşehan
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CHRONIC diseases & psychology ,PARENT attitudes ,PSYCHOLOGY of mothers ,TYPE 1 diabetes ,SOCIOECONOMIC factors ,INCOME ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,DISEASE management ,PSYCHOLOGICAL stress ,CHILDREN - Abstract
Objective: With the diagnosis of chronic illness in children, a stressful period is likely to begin for both the affected child and their families. The aim of this study was to investigate the factors affecting chronic disease management by the parents of children diagnosed with type 1 diabetes mellitus (T1DM). Methods: The sample consisted of 110 children, aged between 4-17 years and their mothers. The patients had been diagnosed with T1DM for at least one year, and had attended pediatric endocrinology outpatients or were hospitalized in a single center. First, sociodemographic information about the child with T1DM were obtained. Then, the “Family Management Measure” (FaMM) was applied. The FaMM is constructed to measure family functioning and management in families who have a child with a chronic illness. Results: Paternal years of education (p=0.036), family income (p=0.008), insulin pump use (p=0.011), and time elapsed after diagnosis (p=0.048) positively affected both the management of T1DM and the child’s daily life. However, presence of chronic diseases in addition to T1DM (p=0.004) negatively affected diabetes management. Higher maternal education year (p=0.013) and family income level (p=0.001) increased parental mutuality scores. However, as the time after diagnosis increased, parental mutuality scores decreased. Conclusion: It is important to evaluate the child with chronic disease with a biopsychosocial approach. This approach aims to evaluate the problems of the child and his/her family who experience the disease with a holistic approach. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Frequency of Dyslipidemia and Associated Risk Factors Among Obese Children and Adolescents in Turkey
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Dündar, İsmail, primary and Akıncı, Ayşehan, additional
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- 2022
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11. Prevalence of type 2 diabetes mellitus, metabolic syndrome, and related morbidities in overweight and obese children
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Dündar, İsmail, primary and Akıncı, Ayşehan, additional
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- 2022
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12. Etiological, clinical, and laboratory evaluation of congenital hypothyroidism and determination of levothyroxine (LT4) dose at treatment interruption in differentiating permanent vs. transient patients
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DÜNDAR, İSMAİL, primary, BÜYÜKAVCI, MEHMET AKİF, additional, and ÇİFTCİ, NURDAN, additional
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- 2022
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13. Trend in initial presenting features of type 1 diabetes mellitus over a 24 year period in turkey: a retrospective analysis of 814 cases
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Dündar, İsmail, primary, Akıncı, Ayşehan, additional, Camtosun, Emine, additional, Çiftçi, Nurdan, additional, Kayas, Leman, additional, and Nalbantoğlu, Özlem, additional
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- 2022
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14. Evaluation of Children and Adolescent Cases Admitted to the Pediatric Emergency Department for Drug Intoxication
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Dündar, İsmail, primary, Akın, Yasemin, additional, Yücel, Melek, additional, and Yaykıran, Dündar, additional
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- 2021
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15. Pediatric Primary Adrenal Insufficiency: A 21-year Single Center Experience
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Çamtosun, Emine, primary, Dündar, İsmail, additional, Akıncı, Ayşehan, additional, Kayaş, Leman, additional, and Çiftçi, Nurdan, additional
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- 2021
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16. The Frequency of Subclinical Hypothyroidism in Obese Children and Adolescents and Its Relationship with Metabolic Parameters and Atherogenic Index.
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Dündar, İsmail and Akıncı, Ayşehan
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LIPID metabolism , *CARDIOVASCULAR diseases risk factors , *THYROTROPIN , *HOMEOSTASIS , *HYPOTHYROIDISM , *CHILDHOOD obesity , *CROSS-sectional method , *THYROXINE , *HEALTH outcome assessment , *HYPOTHYROIDISM in children , *METABOLIC disorders , *DESCRIPTIVE statistics , *TRIIODOTHYRONINE , *BODY mass index , *INSULIN resistance , *ASPARTATE aminotransferase , *ALANINE aminotransferase - Abstract
Objective: The effect of subclinical hypothyroidism on glucose and lipid metabolism in obese children is controversial. This study aims to compare cardiovascular risk factors in obese patients with or without subclinical hypothyroidism and determine the frequency of subclinical hypothyroidism in obese children and adolescents. Materials and Methods: A total of 1130 obese children and adolescents aged 6-18 years were included in this single-center cross-sectional study. Metabolic parameters such as thyrotropin, free thyroxine, free triiodothyronine, homeostasis model assessment for insulin resistance, atherogenic index, and lipids were evaluated. The patients were divided into two groups--subclinical hypothyroidism group (free thyroxine normal, thyroid-stimulating hormone 5.5-10 mlU/L) (n = 59) and the control group (free thyroxine normal, thyroid-stimulating hormone < 5 mlU/L) (n = 1071). Results: Subclinical hypothyroidism was detected in 59 (5.2%) of 1130 patients. The mean body mass index was similar in both groups. The mean serum insulin, homeostasis model assessment for insulin resistance, triglyceride, atherogenic index of plasma, aspartate aminotransferase, and alanine aminotransferase levels were higher in the subclinical hypothyroidism group, and the mean high-density lipoprotein cholesterol level was lower than the control group (P = .005, P < .001, P = .028, P < .001, P = .001, P < .001, and P = .018, respectively). While a positive correlation was observed between the thyroid-stimulating hormone levels and insulin, homeostasis model assessment for insulin resistance, alanine aminotransferase, triglyceride, and basal cortisol levels, a negative correlation was found between thyroid-stimulating hormone and high-density lipoprotein cholesterol. Conclusion: Subclinical hypothyroidism can negatively affect the lipid and glucose profile. [ABSTRACT FROM AUTHOR]
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- 2022
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17. NUTRİSYONEL RAŞİTİZM HALEN BİR SORUN: D VİTAMİNİ PROFİLAKSİSİ PROGRAMINA SIKI SARILMALIYIZ
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ÇAMTOSUN, Emine, primary, AKINCI, Ayşehan, additional, ÇELİK, Nurullah, additional, and DÜNDAR, İsmail, additional
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- 2020
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18. TÜRKİYEDE ÇOCUK VE ERGEN TİP 1 DİYABET KOHORT ÇALIŞMASI İLK YIL SONUÇLARI
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TAŞ, FUNDA FERYAL, PAPATYA ÇAKIR, ESRA DENİZ, YEŞİLTEPE MUTLU, RAHİME GÜL, PARLAK, MESUT, muratoğlu şahin, nursel, ÇETİNKAYA, SEMRA, ünal, edip, ERBAŞ, İBRAHİM MERT, AYCAN, ZEHRA, MENGEN, EDA, DEMİRAL, MELİHA, DENKBOY ÖNGEN, YASEMİN, YILDIRIM, RUKEN, ÖZSU, ELİF, BİNAY, ÇİĞDEM, DİREK, GÜL, AKYÜREK, NESİBE, AŞAN, ÖNDER, YÜKSEL, BİLGİN, EVLİYAOĞLU, OLCAY, nalbant, özlem, KARAKILIÇ ÖZTURAN, ESİN, ANIK, AHMET, KILINÇ, SUNA, EKLİOĞLU, BERAY SELVER, and DÜNDAR, İSMAİL
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- 2019
19. Türkiyede Çocuk ve Ergen Tip 1 Diyabet Kohort Çalışması İlk Yıl Sonuçları
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ERBAŞ, İBRAHİM MERT, AYCAN, ZEHRA, Muratoğlu Şahin, Nursel, Mengen, Eda, ÖZSU, ELİF, BİNAY, ÇİĞDEM, Direk, Gül, Akyürek, Nesibe, Aşan, Önder, YÜKSEL, BİLGİN, Ekioğlu, Beray Selver, TAŞ, FUNDA FERYAL, DÜNDAR, İSMAİL, Papatya Çakır, ESRA dENİZ, YEŞİLTEPE MUTLU, RAHİME GÜL, KILINÇ, SUNA, EVLİYAOĞLU, SAADET OLCAY, KARAKILIÇ ÖZTURAN, ESİN, PARLAK, MESUT, ANIK, AHMET, Nalbant, Özlem, YILDIRIM, RUKEN, DENKBOY ÖNGEN, YASEMİN, Demiral, Meliha, Ünal, Edip, and ÇETİNKAYA, SEMRA
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- 2019
20. Fever of unknown origin in Turkey: evaluation of 87 cases during a nine-year-period of study
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Saltoglu, Nese, Tasova, Yesim, Midikli, Durdane, Aksu, Hasan S.Z, Sanli, Aslihan, and Dündar, Ismail H
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- 2004
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21. Çocuk Acil Servisine İlaç Entoksikasyonu Nedeni ile Başvurmuş Olan Çocuk ve Ergen Olguların Değerlendirilmesi.
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Dündar, İsmail, Akın, Yasemin, Yücel, Melek, and Yaykıran, Dündar
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DRUG overdose ,RETROSPECTIVE studies - Abstract
Copyright of Journal of Pediatric Emergency & Intensive Care Medicine / Çocuk Acil ve Voğun Bakım Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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22. Laron syndrome related to homozygous growth hormone receptor c.784>C mutation in a patient with hypoplastic pulmonary arteries
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Akıncı, Ayşehan, primary, Karakurt, Cemşit, additional, Hwa, Vivian, additional, Dündar, İsmail, additional, and Çamtosun, Emine, additional
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- 2019
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23. İbrahim Gülistan'ın Cûy ve Dîvar ve Teşne adlı eseri (Çeviri-inceleme)
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Dündar, İsmail Tuncay, Temizel, Ali, and Doğu Dilleri ve Edebiyatları Anabilim Dalı
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Translation ,Eastern Linguistics and Literature ,Gülistan, İbrahim ,Literature ,Persion literature ,Iran ,Doğu Dilleri ve Edebiyatı - Abstract
`İbrahim Gülistan'ın Cûy ve Dîvar ve Teşne adlı eseri (Çeviri-İnceleme)` başlıklı bu çalışmanın amacı, Çağdaş İran Edebiyatının önemli isimlerinden biri olan İbrahim Gülistan'ın hayat hikâyesi, edebi üslubu ve eserleri ile ilgili inceleme yapmak ve yazmış olduğu öykülerin sosyal etkilerini ortaya koymaktır. Bu yüzden hem edebiyat hem de sinema sahasında önemli işler başarmış olan İbrahim Gülistan'ın Cûy ve Dîvar ve Teşne adlı öykü mecmuasındaki Çerh-i Felek, Sobh-i Yek Rûz-i Hoş, Mâhî ve Cofteş, Tûtîy-i Morde-i Hemsâye-i Men, Bâ Peserem Rûy-i Râh, Drehthâ ve Ba'd Ez Su'ûd adlı yedi öykünün çevirisi ve incelemesi yapılarak yüksek lisans tez konusu olması uygun görülmüştür. Yapılan bu çalışma, bir giriş ve dört bölümden oluşmaktadır. Giriş bölümünde 20. yüzyılda İran'ın siyasal ve sosyal durumu hakkında bilgi verilmiştir. Birinci bölümde çağdaş İran öykücülüğünün doğuşu, gelişimi ve bu dönem yazarları ve eserleri hakkında inceleme yapılmıştır. İkinci bölümde İbrahim Gülistan'ın hayatı, edebi kişiliği ve eserleri hakkında bilgi verilmiştir. Üçüncü bölümde İbrahim Gülistan'ın Cûy ve Dîvar ve Teşne adlı öykü mecmuasından örnek olarak seçilen yedi öyküsü Türkçeye çevrilmiştir. Dördüncü bölümde Türkçe çevirisi yapılan bu yedi öykü tahlil edilmeye çalışılmıştır. Bu çalışmanın sonunda da Farsça metinle Türkçe metnin karşılaştırılmasını sağlamak için Türkçeye çevrilen öykülerin Farsça metnine de yer verilmiştir. The purpose of this work titled `Ebrahim Golestan's The Brook, The Wall and The Thirsty One (Translation-Analysing)` to investigate his life story, literary style and literary works and reveal the social effects of the stories that he wrote who is Ebrahim Golestan one of the important writers of Contemporary Iranian Literature. So, Ebrahim Golestan who has accomplished important works both in literature and in cinema by translation and examination of the seven stories from his The Brook, The Wall and The Thirsty One named story book, it is considered appropriate to have a master thesis topic. This work consists of an introduction and four parts. In the introduction, information was given about the political, and social situation of Iran in the 20th centuries. In the first part, the rise and development of Contemporary Iranian Storytelling and about the writers and works of this period were examined. In the second part, about Ebrahim Golestan's life, language, style, literary personality and works were informed. In the third part, selected seven stories from Ebrahim Golestan's The Brook, The Wall and The Thirsty One named story book, were translated into Turkish. In the fourth part, these seven stories, which were translated into Turkish, were tried to be analyzed. At the end of this work, to provide a comparison Persian text with Turkish text, the Persian text which its stories translated into Turkish was also included. 237
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- 2017
24. Evaluation of hematological parameters in cases with premature adrenarche
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Çelik, Nurullah, primary, Çamtosun, Emine, additional, and Dündar, İsmail, additional
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- 2018
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25. The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D3-Resistant Rickets
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Akıncı, Ayşehan, primary, Dündar, İsmail, additional, and Kıvılcım, Meltem, additional
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- 2017
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26. The Etiological Distribution of Acute Viral Hepatitis in Children
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Yaman, Akgün, Alhan, S. Emre, Yıldızdaş, Dinçer, ÇETİNER, Salih, Dündar, İsmail Hakkı, Aksaray, Necmi, and Aksungur, Pauline
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virus diseases ,digestive system diseases - Abstract
During the period between December 1994 and December 1995 various hepatitis markers were investigated from an etiological viewpoint in 136 patients Their ages ranged between 3 13 years with an average of 7 6 with jaundice who were considered to have acute viral hepatitis AVH and who had presented to the pediatric outpatient clinic of the Çukurova University Medical School For this purpose the presence of anti HAV IgM HBsAg anti HBc IgM anti HCV anti HEV IgG in the patients sera was investigated using ELISA which was also used to analyse the HBsAg positive sera for the presence of anti delta Besides this cases of non A non B hepatitis were investigated for the presence of HCV RNA using PCR Out of 136 pediatric patients 54 39 7 were diagnosed as having hepatitis A; 50 36 8 hepatitis B; and 2 3 hepatitis C While 9 6 6 of the cases were anti HEV positive none were found to be positive for anti delta Besides this 16 11 8 patients were found to be negative for all of the markers Key words: Hepatitis Markers Children, Çukurova Üniversitesi Tıp Fakültesi Pediatri Polikliniğine Aralık 1994 ve Aralık 1995 tarihleri arasında sarılık nedeniyle başvuran ve akut viral hepatit AVH olduğu düşünülen 136 hastada etyolojiye yönelik çeşitli hepatit markerleri araştırıldı Yaşları 3 13 arasında olup ortalama 7 6 idi Bu amaçla anti HAV IgM HBsAg anti HBc IgM anti HCV anti HEV IgG ve HBsAg si pozitif olanlarda anti delta ELİSA yöntemiyle değerlendirildi Ayrıca non A ve non B olgularında HCV RNA sı PCR ile araştırıldı 136 çocuk hastanın 54 39 7 üne hepatit A 50 36 8 sine hepatit B ve 2 1 5 sine hepatit C tanısı kondu Olguların 9 6 6 unda anti HEV pozitifliği tespit edilirken anti delta pozitifliğine rastlanmadı Bunun yanısıra 16 11 8 hastada tüm markerler negatif olarak bulundu Anahtar kelimeler: Hepatit Markerleri Çocuklar
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- 2014
27. Prematür adrenarşli olgularda hematolojik parametrelerin değerlendirilmesi.
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Çelik, Nurullah, Çamtosun, Emine, and Dündar, İsmail
- Abstract
Copyright of Ortadogu Medical Journal / Ortadogu Tip Dergisi is the property of Bastas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2018
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- View/download PDF
28. The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D3-Resistant Rickets.
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Akıncı, Ayşehan, Dündar, İsmail, and Kıvılcım, Meltem
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HYPERPARATHYROIDISM , *RICKETS treatment , *BALDNESS , *ALKALINE phosphatase , *CALCIUM , *CELL receptors , *CLINICAL drug trials , *GENETIC disorders , *HYPOCALCEMIA , *PARATHYROID hormone , *RICKETS , *VITAMIN D , *DISEASE complications , *DIAGNOSIS - Abstract
High doses of oral calcium or long-term calcium infusions are recommended to correct the hypocalcemia and secondary hyperparathyroidism in patients with hereditary 1,25 dihydroxyvitamin D3-resistant rickets (HVDRR). Preliminary studies revealed that calcimimetics may be a safe and effective therapeutic choice in children with secondary hyperparathyroidism. Our aim was to observe the efficacy of cinacalcet in the normalization of secondary hyperparathyroidism and hypophosphatemia in two siblings aged 2.5 years and 6 months with HVDRR who did not respond to traditional treatment regimes. Both patients were admitted to the hospital with severe hypocalcemia. They were treated with high doses of calcitriol and calcium infusions intravenously. Secondary hyperparathyroidism was normalized temporarily, but did not improve completely. Cinacalcet (0.25 mg/kg) once a day along with the high doses of oral calcium and calcitriol was added to the treatment schedule. After 3 months, biochemical and radiologic findings reverted to normal. Our findings indicate that cinacalcet is effective in normalizing the hyperparathyroidism and hypophosphatemia in these cases and in improving the bone pathology. [ABSTRACT FROM AUTHOR]
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- 2017
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29. TEMSA Fabrikalarında İş Etüdü Uygulaması : Montaj Akış Kartı (AOS)
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Dündar, İsmail, Gökçen, Ersin, and Bölüm Yok
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İş Etüdü,Montaj Akış Kartları (AOS), Montaj Grubu, Doküman Yönetim Sistemi (DMS) - Abstract
Otobüs/Midibüs/Kamyonet üretimi yapılan TEMSA üretim tesislerinde, üretim sürecinin iyileştirilmesi, ürün kalitesinin arttırılması, üretimin değer katmayan her türlü faaliyetten arındırılması amacıyla Üretim Destek Bölümü olarak endüstri mühendisliği uygulamaları gerçekleştirilmektedir. Bu uygulamalardan iş etüdü ile ilgili gerçekleştirilen "Montaj Akış Kartları (AOS)" projesi sunulacaktır. Temsa fabrikalarında seri olarak üretilen veya üretilecek olan araçların üretim süreçlerinde operasyonların standartlaştırılması, SAP sisteminde kayıtlı olan ürün ağaçlarının uygunsuzluklarının saptanması, hazırlanan montaj akış kartlarının SAP sistemine entegre olabilecek bir formata getirilmesi ve "Montaj Akış Kartları (AOS)"nın güncellenmesi, takibi ve yeni kartların hazırlanması için "Doküman Yönetim Sistemi (DMS)"nin oluşturulması bu projesinin içeriğini oluşturmaktadır. İstanbul Ticaret Üniversitesi
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- 2005
30. Otomotiv sektöründe kurumsal karne uygulamasına dayalı performans yönetim sistemi kurulması ve değerlendirilmesi
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Dündar, İsmail, Yüreğir, Oya H., Çukurova Üniversitesi, Fen Bilimleri Enstitüsü, Endüstri Mühendisliği Anabilim Dalı, Yüregir, Hacire Oya, and Endüstri Mühendisliği Anabilim Dalı
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Balanced Scorecard ,Performans yönetim sistemi ,Endüstri ve Endüstri Mühendisliği ,Performance Mangement Systems ,topsis ,Industrial and Industrial Engineering ,critical success factors ,performans ,kritik başarı faktörleri - Abstract
ÖZYÜKSEK LİSANS TEZİOTOMOTİV SEKTÖRÜNDE KURUMSAL KARNE UYGULAMASINADAYALI PERFORMANS YÖNETİM SİSTEMİ KURULMASI VEDEĞERLENDİRİLMESİİsmail DÜNDARÇUKUROVA ÜNİVERSİTESİFEN BİLİMLERİ ENSTİTÜSÜENDÜSTRİ MÜHENDİSLİĞİ ANA BİLİM DALIDanışman: Yrd.Doç.Dr. Oya H. YÜREGİRYıl 2005, Sayfa: 160Jüri: Yrd.Doç.Dr. Oya H. YÜREGİRDoç.Dr. Rızvan EROLYrd.Doç.Dr. Arzu UZUNGünümüzde sadece finansal ölçütlere dayalı olan performans ölçümleri,işletmelerin performanslarını değerlendirmede yeterli olmamaktadır. Bu alandayapılan çalışmalar göstermiştir ki, finansal ölçütlere dayalı olan performans ölçümsitemleri, işletmeler için önemli olan faktörlerin ölçülmesinde yetersiz kalmaktadır.Bu nedenle, işletmeler performans ölçüm sistemlerinin tasarımında maliyetle birliktediğer faktörleri de dikkate almalıdırlar.Yapılan bu çalışmanın amacı; PYS(Performans Yönetim Sistemi) kartlarınıimplemente etmeye çalışan işletmedeki kritik başarı faktörlerini ortaya koymak,BSC(Balanced Scorecard) felsefesinden yararlanarak ilgili sistemi iyileştirmek ve busistemin doğruluğunun ve geçerliliğinin test etmektir. Bu çalışma önceki çalışmalarlabaşlamakta ve performans değerlendirme sistemi literatürünün incelenmesiyle devametmektedir. Literatür taraması sonucunda elde edilen bilgiler ışığında işletmenin birbölümünde PYS kartları implemente edilmiş ve kurulan sistem TOPSIS yöntemi iledoğrulanmıştır. Anket çalışması işletme genelinde uygulanarak sonuçlar vehazırlanan hipotezler SPPS ile analiz ve test edilmiştir. PYS kritik başarı faktörüönem derecesinin çalışanlar açısından önemli bulunmasına rağmen işletmedegerçekleşme düzeyinin yeterli olmadığı sonucu elde edilmiştir.Anahtar kelimeler: Performans yönetim sistemi, performans, kritik başarı faktörleri,topsis, balanced scorecard,I ABSTRACTMS THESISBULDING UP AND EVALUATION OF A PERFORMANCE MANAGEMENTSYSTEM BASED ON BALANCED SCORECARD FOR AUTOMOTIVE SECTORİsmail DÜNDARÇUKUROVA UNIVERSITYINSTITUTE OF BASIC AND APPLIED SCIENCESFACULTY OF ENGINEERING AND ARCHITECTUREDEPT. OF INDUSTRIAL ENGINEERINGSupervisor: Ass. Prof. Oya H. YÜREGİRYear 2005, Page: 160Jury: Ass. Prof.Dr. Oya H. YÜREGİRAssociate Prof.Dr. Rızvan EROLAss. Prof.Dr. Arzu UZUNToday, performance measurement systems based on only financial criteriansare not sufficient to evaluate the performance of private and public buisinessenterprises. Current studies show that peformance measurement systems taking onlythe financial measures into consideration are not able to measure the most importantfactors for operational side. Consequently, operational plants should include otherfactors besides the financial ones in the foundation of their performancemeasurement systems.The objective of this study is to bring up the critical success factors foroperations trying to implement Balanced Scorecard, by utilizing BSC philosophy toimprove the relavant system and to test its accuracy and effectiveness. This studystarts with the examination of past studies and continues with the literature surveyabout performance management systems. In the light of the datum obtained fromliterature survey, BSC was implemented in some part of the plant and the system wasverified with TOPSIS method. The results obtained from the poll taken from all overthe plant personnel and the hypothesis set up were analyzed and tested with SPPSmethod. Although the level of importance of performance management systemcritical success factors in plant personnel?s opinion was found as adequate, therealization in practice was found insufficient.KeyWords: Performance Mangement Systems, critical success factors, TOPSIS,Balanced Scorecard.II 172
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- 2005
31. Yoğun bakım ünitelerinde infeksiyon nedeniyle izlenen hastalarda etkenler, risk faktörleri, antibiyotik direnci ve prognozun değerlendirilmesi
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Saltoğlu, Neşe, Paydaş, Saime, Dündar, İsmail Hakkı, İncecik, Şaban, Taşova, Yeşim, and Öztürk, Candan
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- 2000
32. An evaluation of antimicrobial resistance of gram- negative isolates in intensive care units (ICU)
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Saltoğlu, Neşe, Dündar, İsmail Hakkı, İncecik, Şaban, and Taşova, Yeşim
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- 2000
33. Reference Ranges of Lymphocyte Subsets of Healthy Adults in Turkey
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Yaman, Akgün, primary, Çetiner, Salih, additional, Kibar, Filiz, additional, Taşova, Yeşim, additional, Şeydaoğlu, Gülşah, additional, and Dündar, İsmail H., additional
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- 2005
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34. Erişkinde 98 Ekstrapulmoner Tüberküloz Olgusunun Değerlendirilmesi.
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Taşova, Yeşim, Saltoğlu, Neşe, Mıdıklı, Dürdane, Kandemir, Özlem, Aksu, Hasan S. Z., and Dündar, İsmail Hakkı
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- 2000
35. Tifo: 40 Olgunun Değerlendirilmesi.
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Yeşim, Taşoval, Saltoğlu, Neşe, Yaman, Akgün, Kılıç, N. Banu, and Dündar, İsmail H.
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- 1997
36. Erişkin akut gastroenterit olgularında etiyolojik ajanların belirlenmesi
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İnal, A. Seza, Dündar, İsmail H., and Klinik Bakteriyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı
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Diarrhea ,Bacteria ,Antibiotics ,Clinical Microbiology and Infectious Diseases ,Viruses ,Klinik Bakteriyoloji ve Enfeksiyon Hastalıkları ,Protozoa ,Gastroenteritis - Abstract
ÖZET Akut gastroenteritler bütün dünyada her yaştan insanda görülebilen ve kişilerin günlük yaşamını en çok etkileyen hastalık grubudur. İshalli hastalıklar, dünyadaki bütün ölüm nedenleri arasında kardiyovasküler hastalıkların arkasından ikinci sırada yer alırlar. Olası gastroenterit etkenlerinin bilinmesi, tanıya yönelik araştırmalarda kolaylık, doğru tanı ve etkin tedavi firsatı sağlayacak, ayrıca antimikrobiyal tedavi gereken durumlarda antibiyotik seçimi için yol gösterecektir. Akut gastroenteritlerde etiyolojik ajanların belirlenmesi amacıyla, ishal şikayetiyle başvuran 110 hastanın dışkı örneklerinde bakteriyolojik, parazitolojik ve virolojik incelemeler yapılmıştır. Son 10 gün içinde antibiyotik kullanımı öyküsü olan hastaların dışkılarında Clostridium difficile Toksin A araştırılmıştır. Hastaların %44,5'unda akut gastroenterit etkeni olarak en az bir patojen belirlenmiş, %55,5'inde ise etken belirlenememiştir. Hastaların ll'inde amebiyazis (%10,0), ll'inde şigellozis (%10,0), ll'inde rotavirus enfeksiyonu (%10,0), 5'inde giyardiyazis (%4,5), 3'ünde saknonellozis (%2,7) saptanmıştır. 6 farklı hastanın her birinde Enteropatojenik Escherichia colfye (%0,9), Clostridium difficile'ye (%0,9) ve Blastocystis hominis's bağlı ishal (%0,9), şigellozis+amebiyazis (%0,9), amebiyazis+giyardiyazis (%0,9), Candida+Rotayrrüs enfeksiyonu (%0,9) belirlenmiştir. Olguların % 2,7'sinde (a3) mikst enfeksiyon bulunmuştur. Etkenlerin sıklığı ve patojenler içindeki oram her mikroorganizma için ayrı ayrı değerlendirildiğinde, en sık saptanan patojen Entamoeba histolytica'da (a 13, %26). Bunu Shigella türleri (al2, %24) ve rotavirüsler (ali, %22) izlemektedir. Salmonella türlerinde direnç saptanmamış olmakla birlikte, Shigella izolatlannın %83,3'ünde (n:10) en az bir antibiyotiğe direnç saptanmıştır. Bu dirençli izolatlann tamamında (n:10,%83,3) trimetoprim- sulfametoksazol direnci, daha az oranda ampisilin direnci (n:5, %33,4) dikkat çekmektedir. Bölgemizdeki ishallerin etiyolojisinde, protozoonlar ve bakteriyel etkenlerle birlikte rotavirüsler de önemli yer tutmaktadır. Anahtar Sözcükler: Gastroenterit, ishal, etiyoloji. ABSTRACT ETIOLOGIC AGENTS OF ACUTE GASTROENTERITIS IN ADULTS Acute gastroenteritis is the most affecting diseases of life in all ages. Diarrheal diseases are the second cause of death next to cardiovascular diseases worldwide. Designating of the probable agents of gastroenteritis provide knowledge to diagnose easily,, treat effectively, and choose antimicrobial agent appropriately. In order to determine etiologic agents of acute gastroenteritis, stools of 110 patients with diarrhea examined. Stools of the patients who had taken antibiotics within 10 days, were investigated for Clostridium difficile toxin A. At least one pathogen were identified in 44.5% of the patients. The diagnosis of patients were amebiasis in 11 (10.0%), shigellosis in 11 (10.0%), and rotaviral infection in 11 (10.0%), giardiasis in 5 (4.5%), salmonellosis in 3 (2.7%). Each of remaining six patients had diarrhea caused by Enteropathogenic Escherichia coli (0.9%), Clostridium difficile (0.9%), Blastocystis hominis (0.9%), Shigella* Entamoeba histolytica (0.9%), Entamoeba histolytica+Giardia lamblia (0.9%), Candida+totaymis (0.9%). 2,7% of cases had mixed infection. Entamoeba histolytica (n:13 ), Shigella spp. (n:12), and rotaviruses (n:ll) were isolated most frequently ( 26%, 24%, 22% among all pathogens identified, respectively). Although none of the Salmonella isolates were resistant, 83.3% resistance to at least one antibiotic of Shigella isolates (n:10) were striking. Resistance to trimethoprim- sulfamethoxazole and ampicillin were 83.3% and 33.4%, respectively. Of diarrheal diseases in this region, rotaviruses are also important pathogens as much as protoza and bacteria for adults. Keywords: Gastroenteritis, diarrhea, etiology. VI 72
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- 2000
37. Menenjitli hastalarda hızlı tanı yöntemlerinin değerlendirilmesinin önemi
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Kilçik Aslan, Arzu, Dündar, İsmail Hakkı, and Klinik Bakteriyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı
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Clinical Microbiology and Infectious Diseases ,Diagnosis ,Klinik Bakteriyoloji ve Enfeksiyon Hastalıkları ,Meningitis - Abstract
ÖZET Santral sinir sistemi (S S S) enfeksiyonları fatalitesi oldukça yüksek ve tedavisinin olabildiğince erken sürede başlanması gereken enfeksiyonlardır. Modern antimikrobiyal tedavinin gelişmesi ile menenjitlerin ölümcül prognozu azaltılabilmektedir. Bununla birlikte SSS enfeksiyonlarında uygun tedavinin yapılabilmesi için doğru ve hızlı tanısının konulabilmesi şarttır. SSS enfeksiyonu olan hastalan değerlendirmede birçok test kullanılabilir. Beyin omurilik sıvısı (BOS) analizi SSS enfeksiyonu düşünülen hastaların tanısının konulmasmda en önemli role sahiptir. Gram boyası ve uygun kültür hala önemini korumakla birlikte duyarlı ve hızlı agglutinasyon testlerinin uygulanması bakteriyel menenjitlerin erken ayırıcı tanısını kolaylaştırır. Bu testlerden biri olan Limulus amebocyte lizat (LAL) testi BOS'da gram negatif bakteri endotoksinini bulmada duyarlı bir yöntemdir. Bu çalışma, Ocak 1994-Haziran 1997 arasında menenjit ön tanılı hastalarda BOS laboratuvar bulgularını ve tedavideki önemini değerlendirmek amacıyla yapılmıştır. Kliniğimizde menenjit ön tanılı hastaların yaşlan 14-75 arasında ve yaş ortalaması 32.6±16. l'di. Menenjit türü oranlan sırasıyla %42.2 bakteriyel menenjit, %36.2 tüberküloz menenjit ve %21.9'u viral menenjit olarak değerlendirilmiştir. Bu hastalarda fatalite hızı %27.47' idi. Bakteriyel menenjitte gram boyası %57.8, bakteriyel antijen tayini %19.78 ve kültür %28.94 oranında pozitif bulunmuştur. Tüberküloz menenjitte kültür %24.4, direkt aside rezistan basil (dARB) oranı %18.1 ve adenosine deaminaz (ADA) pozitifliği %60 (10 IU/L'nin üstünde) bulunmuştur. Limulus amebocyte lizat (LAL) pozitifliği bakteriyel menenjit ön tandı olguların hiçbirinde saptanmamıştır. Anahtar Kelimeler: Menenjit, BOS, gram boyası, agglutinasyon testi, limulus amebocyte lizat (LAL) testi. IV ABSTRACT ACUTE DIAGNOSIS OF CEREBROSPINAL FLUID LABORATORY FINDINGS IN MENINGITIS PATIENTS Prompt and accurate diagnosis of central nervous system (CNS) infections is of vital importance to the emergency physician. With the advent of modern antimicrobial therapy, the nearly uniformly fatal outcome of untreated meningitis can be reduced substantially. Proper test selection is crucial in arriving at a correct and timely diagnosis. A variety of tests are currently available for evaluation of the patient with CNS infection. Analysis of the cerebrospinal fluid (CSF) has become an indispensable procedure in evaluating the patient with a suspected CNS infection. Gram stain and appropriate culture procedures still provide the basis for comparing other diagnostic methods. The advent of very sensitive and rapid agglutination tests has been a major advance in facilitating rapid diagnosis of meningitis. The limulus amebocyte lysate (LAL) assay is a very sensitive and specific assay for the detection of endotoxin in CSF. The aim of this study which was carried out between January 1994- June 1997 was to evaluate the CSF laboratory findings. In patients which had been diagnosed as meningitis, patients were between 14-75 years of age and age ratio was 32.6+16.1. The ratio of meningitis was, 42.2% bacterial, 36.2% tuberculosis, 21.9% viral meningitis. The rate of mortality in these patients were 27.47%. In bacterial meningitis the percentage of gram stain was 57.8%, bacterial antigen (latex agglutination ) 19.78% and culture 28.94%. In tuberculosis meningitis the percentage of culture was 24.4%. Acid fast bacilli were seen in the prcentage of 18.1% and adenosine deaminase activity which was >10IU/L, was found 60%. LAL positivity was seen neither of the bacterial meningitis. Key Words: Meningitis, CSF, Gram stain, Agglutination tests, Limulus amebocyte lysate (LAL). 59
- Published
- 1998
38. Nonperfore akut apandisitte tek doz antibiyotik profilaksisinin yara enfeksiyonunu önlemekteki yeri
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Demircan, Orhan, Dündar, İsmail Hakkı, and Diğer
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Antibiotics ,General Surgery ,Wound infection ,Genel Cerrahi ,Appendicitis - Abstract
ÖZET Bu prospektif klinik çalışma; nonperfore akut apandisitler için acil apandektomi sonrası yara enfeksiyonununun önlenmesinde tek doz sistemik antibiyotik prof ilaksisinin etkisini belirlemek amacıyla gerçekleştirildi. Şubat 1990-Kasım 1991 tarihleri arasında Çukurova Üniversitesi Tıp Fakültesi Genel Cerrahi Ana Bilim Dalında akut apandisit tanısıyla birbirini takiben öpere edilen 105 hastada gerçekleştirildi. 24 hasta çeşitli nedenlerle çalışmadan çıkartıldı ve çalışma 81 hasta ile tamamlandı. Hastalar çalışma (I. grup) ve kontrol (II. grup) grubu olarak ikiye ayrıldı. I.grupta 40, II. grupta 41 hasta vardı. I. gruptaki hastalara operasyondan önce intravenöz 1 gram seftriakson uygulandı. II. gruba antibiyotik verilmedi. Hastalar gruplara çalışma ekibi tarafından tesadüfi olarak seçildiler. Yaş ortalaması 29 olup en küçük yaş 1 5, en büyük yaş ise 65 idi. Hastalarımızın 46'sı (%56,8) erkek, 35'i (%43,2) kadındı. Gruplarda semptomların süresi, operasyon süresi ve apandikslerin patolojik sınıflandırması benzerdi. Her iki grupta operasyon sırasında douglas, apandiküler fossa ve cilt altı dokusundan aerob ve anaerob kültürler alındı. En fazla üreyen aerob organizma E.coli, anaerob ise Peptostreptokok'tu. Çalışmamızda toplam sekiz(%9,8) hastada yara enfeksiyonu meydana geldi. I.grupta bir(%2,3) hastada, II. grupta yedi(%17) hastada yara enfeksiyonu gelişti, iki grup arasındaki fark istatistiksel olarak anlamlıydı (p < 0,02). Yara enfeksiyonu gelişen hastaların birinde akut apandisit, yedisinde ise gangrenöz apandisit mevcut idi. Yara enfeksiyonu gelişen hastalarda aerob ve anaerob kültürlerde en fazla üreyen mikroorganizmanın E.coli olduğu görüldü. Semptomların süresinin 36 saatin üzerinde olması, apandiksin gangrene kadar giden enflamasyon derecesinin yüksekliği ve pozitif bakteriyel kontaminasyon varlığının yara enfeksiyonunu artıran etkenler oldukları görüldü. I.grupta bir hastada ileus, bir hastada yarada hematom, II. grupta bir hastada pnömonik infiltrasyon, bir hastada üriner enfeksiyon, bir hastada evantrasyon gelişti. İki grupta da intraabdominal enfeksiyon gelişmedi ve eksitus olmadı. Postoperatif hastanede kalış süresi I.grupta ortalama 3,5, ».grupta 4,4 gün idi. Hastanede kalış ve yara enfeksiyonu tedavilerini içeren maliyet analizinde profilaksi uygulanan gruptaki her bir hasta için net kazanç 56290 TL bulundu. Nonperfore akut apandisitlerde tek doz sistemik seftriakson profilaksisinin, apandektomi sonrası yara enfeksiyonu gelişimini önlemekte yeterli olduğu saptandı. 42 45
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- 1992
39. Comprehensive Insights Into Pediatric Craniopharyngioma: Endocrine and Metabolic Profiles, Treatment Challenges, and Long-term Outcomes from a Multicenter Study
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Şıklar Z, Özsu E, Kızılcan Çetin S, Özen S, Çizmecioğlu-Jones F, Balkı HG, Aycan Z, Gökşen D, Kilci F, Abseyi SN, Tercan U, Gürpınar G, Poyrazoğlu Ş, Darendeliler F, Demir K, Besci Ö, Özgen İT, Akın SB, Kocabey Sütçü Z, Aykaç Kaplan EH, Çamtosun E, Dündar İ, Sağsak E, Korkmaz HA, Anık A, Yeşiltepe Mutlu G, Özcabi B, Uçar A, Dağdeviren Çakır A, Selver Eklioğlu B, Kırel B, and Berberoğlu M
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- Humans, Female, Male, Child, Adolescent, Child, Preschool, Infant, Endocrine System Diseases epidemiology, Endocrine System Diseases therapy, Endocrine System Diseases etiology, Follow-Up Studies, Treatment Outcome, Craniopharyngioma therapy, Craniopharyngioma epidemiology, Pituitary Neoplasms therapy, Pituitary Neoplasms epidemiology
- Abstract
Objective: Craniopharyngiomas (CPG) have complex treatment challenges due to their proximity to vital structures, surgical and radiotherapeutic complexities, and the tendency for recurrence. The aim of this study was to identify the prevalence of endocrine and metabolic comorbidities observed during initial diagnosis and long-term follow-up in a nationwide cohort of pediatric CPG patients. A further aim was to highlight the difficulties associated with CPG management., Methods: Sixteen centers entered CPG patients into the ÇEDD NET data system. The clinical and laboratory characteristics at presentation, administered treatments, accompanying endocrine, metabolic, and other system involvements, and the patient’s follow-up features were evaluated., Results: Of the 152 evaluated patients, 64 (42.1%) were female. At presentation, the mean age was 9.1±3.67, ranging from 1.46 to 16.92, years. The most common complaints at presentation were headache (68.4%), vision problems (42%), short stature (15%), and nausea and vomiting (7%). The surgical procedures were gross total resection (GTR) in 97 (63.8%) and subtotal resection in 55 (36.2%). Radiotherapy (RT) was initiated in 11.8% of the patients. Histopathological examination reported 92% were adamantinamatous type and 8% were papillary type. Postoperatively, hormone abnormalities consisted of thyroid-stimulating hormone (92.1%), adrenocorticotropic hormone (81%), antidiuretic hormone (79%), growth hormone (65.1%), and gonadotropin (43.4%) deficiencies. Recombinant growth hormone treatment (rhGH) was initiated in 27 (17.8%). The study showed hesitancy among physicians regarding rhGH. The median survival without relapse was 2.2 years. Median (range) time of relapse was 1.82 (0.13-10.35) years. Relapse was related to longer followups and reduced GTR rates. The median follow-up time was 3.13 years. Among the last follow-up visits, the prevalence of obesity was 38%, but of these, 46.5% were already obese at diagnosis. However, 20% who were not obese at baseline became obese on follow-up. Permanent visual impairment was observed in 26 (17.1%), neurological deficits in 13 (8.5%) and diabetes mellitus in 5 (3.3%) patients., Conclusion: Recurrence was predominantly due to incomplete resection and the low rate of postoperative RT. Challenges emerged for multidisciplinary regular follow ups. It is suggested that early interventions, such as dietary restrictions and increased exercise to prevent obesity, be implemented., Competing Interests: Conflict of Interest: Three authors of this article, Damla Gökşen, Korcan Demir, Samim Özen, are member of the Editorial Board of the Journal of Clinical Research in Pediatric Endocrinology. However, they did not take part in any stage of the editorial decision of the manuscript. The editors who evaluated this manuscript are from different institutions. The other authors declared no conflict of interest., (©Copyright 2024 by Turkish Society for Pediatric Endocrinology and Diabetes / The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House.)
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- 2024
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40. Chronic Disease Management of Children Followed with Type 1 Diabetes Mellitus
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Güven Baysal Ş, Çiftci N, Dündar İ, Büyükavcı MA, Yağın FH, Çamtosun E, Gümüş Doğan D, and Akıncı A
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- Humans, Child, Male, Female, Child, Preschool, Adolescent, Mothers, Chronic Disease, Disease Management, Melanoma, Cutaneous Malignant, Diabetes Mellitus, Type 1 therapy, Diabetes Mellitus, Type 1 psychology
- Abstract
Objective: With the diagnosis of chronic illness in children, a stressful period is likely to begin for both the affected child and their families. The aim of this study was to investigate the factors affecting chronic disease management by the parents of children diagnosed with type 1 diabetes mellitus (T1DM)., Methods: The sample consisted of 110 children, aged between 4-17 years and their mothers. The patients had been diagnosed with T1DM for at least one year, and had attended pediatric endocrinology outpatients or were hospitalized in a single center. First, sociodemographic information about the child with T1DM were obtained. Then, the “Family Management Measure” (FaMM) was applied. The FaMM is constructed to measure family functioning and management in families who have a child with a chronic illness., Results: Paternal years of education (p=0.036), family income (p=0.008), insulin pump use (p=0.011), and time elapsed after diagnosis (p=0.048) positively affected both the management of T1DM and the child’s daily life. However, presence of chronic diseases in addition to T1DM (p=0.004) negatively affected diabetes management. Higher maternal education year (p=0.013) and family income level (p=0.001) increased parental mutuality scores. However, as the time after diagnosis increased, parental mutuality scores decreased., Conclusion: It is important to evaluate the child with chronic disease with a biopsychosocial approach. This approach aims to evaluate the problems of the child and his/her family who experience the disease with a holistic approach., (©Copyright 2023 by Turkish Society for Pediatric Endocrinology and Diabetes | The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House.)
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- 2023
- Full Text
- View/download PDF
41. Laron syndrome related to homozygous growth hormone receptor c.784>C mutation in a patient with hypoplastic pulmonary arteries.
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Akinci A, Karakurt C, Hwa V, Dündar I, and Çamtosun E
- Subjects
- Child, Female, Genetic Predisposition to Disease, Humans, Laron Syndrome diagnosis, Phenotype, Pulmonary Artery diagnostic imaging, Pulmonary Artery surgery, Carrier Proteins genetics, Homozygote, Laron Syndrome genetics, Mutation, Pulmonary Artery abnormalities
- Abstract
Laron syndrome, also known as growth hormone insensitivity, is an autosomal recessive disorder characterised by short stature due to mutations or deletions in the growth hormone receptor (GHR), leading to congenital insulin-like growth factor 1 (IGF1) deficiency. Cardiac abnormalities, such as patent ductus arteriosus or peripheral vascular disease are rare in patients with Laron syndrome, but cardiac hypertrophy has been observed after IGF1 therapy. In this report, we present a 10-year-and-5-month-old girl with severe peripheral-type pulmonary artery hypoplasia and Laron syndrome related to homozygous GHR c.784>C mutation.
- Published
- 2019
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